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Gene: Sgms1 (sphingomyelin synthase 1) Rattus norvegicus
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Symbol: Sgms1
Name: sphingomyelin synthase 1
Description: Predicted to have ceramide cholinephosphotransferase activity; ceramide phosphoethanolamine synthase activity; and sphingomyelin synthase activity. Involved in several processes, including cellular response to lipopolysaccharide; cellular response to tumor necrosis factor; and inflammatory response. Predicted to localize to the Golgi apparatus; integral component of endoplasmic reticulum membrane; and integral component of plasma membrane. Used to study pulmonary edema. Biomarker of pulmonary edema. Orthologous to human SGMS1 (sphingomyelin synthase 1); PARTICIPATES IN Fabry disease pathway; Gaucher's disease pathway; Krabbe disease pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: MGC93062; Mob; mob-1; phosphatidylcholine:ceramide cholinephosphotransferase 1; Tmem23; transmembrane protein 23
Orthologs:
Homo sapiens (human) : SGMS1 (sphingomyelin synthase 1)  HGNC  Alliance
Mus musculus (house mouse) : Sgms1 (sphingomyelin synthase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sgms1 (sphingomyelin synthase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SGMS1 (sphingomyelin synthase 1)
Canis lupus familiaris (dog) : SGMS1 (sphingomyelin synthase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sgms1 (sphingomyelin synthase 1)
Sus scrofa (pig) : SGMS1 (sphingomyelin synthase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01250,692,448 - 250,951,685 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01257,923,300 - 258,182,214 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41236,133,441 - 236,396,631 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11236,319,654 - 236,381,276 (-)NCBI
Celera1227,118,516 - 227,377,318 (-)NCBICelera
Cytogenetic Map1q52NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Sgms1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 727912
Created: 2003-11-05
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.