Fus (Fus RNA binding protein) - Rat Genome Database

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Gene: Fus (Fus RNA binding protein) Rattus norvegicus
Analyze
Symbol: Fus
Name: Fus RNA binding protein
RGD ID: 1308864
Description: Enables ionotropic glutamate receptor binding activity; myosin V binding activity; and nuclear receptor binding activity. Involved in cellular response to calcium ion. Located in dendritic spine head; perikaryon; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 6; essential tremor 4; liposarcoma; and neurodegenerative disease. Orthologous to human FUS (FUS RNA binding protein); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 16) in malignant liposarcoma); 16) malignant liposarcoma; fused in sarcoma; fusion (involved in t(12; fusion (involved in t(12,16) in malignant liposarcoma); fusion (involved in t(12,16) in malignant liposarcoma) (human); fusion, derived from t(12; fusion, derived from t(12,16) malignant liposarcoma; fusion, derived from t(12,16) malignant liposarcoma (human); fusion, derived from t(12;16) malignant liposarcoma; LOC317385; RNA-binding protein FUS
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Fusem1Ionsz  
Genetic Models: SD-Fusem1Ionsz
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81192,007,011 - 192,020,887 (+)NCBIGRCr8
mRatBN7.21182,576,479 - 182,590,417 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,576,545 - 182,590,414 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1190,927,082 - 190,940,953 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01198,113,173 - 198,127,044 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01190,783,656 - 190,797,528 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01199,412,805 - 199,426,705 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,412,834 - 199,426,702 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01206,435,510 - 206,449,423 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,250,871 - 187,264,742 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11187,400,751 - 187,414,620 (+)NCBI
Celera1180,227,600 - 180,241,475 (+)NCBICelera
Cytogenetic Map1q37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(Z)-3-butylidenephthalide  (ISO)
1,2-dimethylhydrazine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[ghi]perylene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
buspirone  (EXP)
buta-1,3-diene  (ISO)
Butylparaben  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
cerium trichloride  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
Ethylenethiourea  (EXP)
ferric oxide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
glafenine  (EXP)
glyphosate  (ISO)
graphene oxide  (ISO)
iron dichloride  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP,ISO)
methylparaben  (ISO)
naphthalene  (ISO)
nefazodone  (EXP)
nickel sulfate  (ISO)
nonanoic acid  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenic acid  (ISO)
selenium atom  (ISO)
selenomethionine  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
succimer  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Delocalization of the multifunctional RNA splicing factor TLS/FUS in hippocampal neurones: exclusion from the nucleus and accumulation in dendritic granules and spine heads. Belly A, etal., Neurosci Lett. 2005 May 13;379(3):152-7. Epub 2005 Jan 25.
2. Transportin1: a marker of FTLD-FUS. Brelstaff J, etal., Acta Neuropathol. 2011 Nov;122(5):591-600. Epub 2011 Aug 17.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. FUS transgenic rats develop the phenotypes of amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Huang C, etal., PLoS Genet. 2011 Mar;7(3):e1002011. doi: 10.1371/journal.pgen.1002011. Epub 2011 Mar 3.
6. Specificity of fusion genes in adipocytic tumors. Kubo T, etal., Anticancer Res. 2010 Feb;30(2):661-4.
7. Low-grade fibromyxoid sarcoma of the small intestine: report of 4 cases with molecular cytogenetic confirmation. Laurini JA, etal., Am J Surg Pathol. 2011 Jul;35(7):1069-73.
8. Low-grade fibromyxoid sarcoma of the perineum with heterotopic ossification: case report and review of the literature. Lee AF, etal., Hum Pathol. 2011 Nov;42(11):1770-5. Epub 2011 Jun 11.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. TLS (translocated-in-liposarcoma) is a high-affinity interactor for steroid, thyroid hormone, and retinoid receptors. Powers CA, etal., Mol Endocrinol. 1998 Jan;12(1):4-18.
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Clinical and neuroanatomical signatures of tissue pathology in frontotemporal lobar degeneration. Rohrer JD, etal., Brain. 2011 Sep;134(Pt 9):2565-81.
17. TLS interaction with NMDA R1 splice variant in retinal ganglion cell line RGC-5. Selamat W, etal., Neurosci Lett. 2009 Jan 30;450(2):163-6. doi: 10.1016/j.neulet.2008.12.014. Epub 2008 Dec 16.
18. FUS mutations in sporadic amyotrophic lateral sclerosis: Clinical and genetic analysis. Sproviero W, etal., Neurobiol Aging. 2011 Nov 3.
19. Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6. Vance C, etal., Science. 2009 Feb 27;323(5918):1208-11. doi: 10.1126/science.1165942.
Additional References at PubMed
PMID:10567410   PMID:12477932   PMID:12950080   PMID:16365397   PMID:18509338   PMID:20616880   PMID:21909421   PMID:22658674   PMID:22681889   PMID:22710833   PMID:23975937   PMID:25453086  
PMID:26124092   PMID:27378374   PMID:27731383   PMID:29610493   PMID:30273830   PMID:31220774   PMID:34193962   PMID:35352799   PMID:35659652   PMID:37918704  


Genomics

Comparative Map Data
Fus
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81192,007,011 - 192,020,887 (+)NCBIGRCr8
mRatBN7.21182,576,479 - 182,590,417 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,576,545 - 182,590,414 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1190,927,082 - 190,940,953 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01198,113,173 - 198,127,044 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01190,783,656 - 190,797,528 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01199,412,805 - 199,426,705 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,412,834 - 199,426,702 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01206,435,510 - 206,449,423 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,250,871 - 187,264,742 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11187,400,751 - 187,414,620 (+)NCBI
Celera1180,227,600 - 180,241,475 (+)NCBICelera
Cytogenetic Map1q37NCBI
FUS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381631,180,110 - 31,194,871 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1631,180,138 - 31,191,605 (+)EnsemblGRCh38hg38GRCh38
GRCh371631,191,431 - 31,206,192 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361631,098,954 - 31,110,601 (+)NCBINCBI36Build 36hg18NCBI36
Build 341631,098,953 - 31,110,598NCBI
Celera1629,091,832 - 29,106,593 (-)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1628,753,052 - 28,767,812 (+)NCBIHuRef
CHM1_11632,509,148 - 32,523,909 (+)NCBICHM1_1
T2T-CHM13v2.01631,567,541 - 31,582,292 (+)NCBIT2T-CHM13v2.0
Fus
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397127,565,276 - 127,581,204 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7127,566,629 - 127,584,873 (+)EnsemblGRCm39 Ensembl
GRCm387127,966,789 - 127,982,032 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,967,457 - 127,985,701 (+)EnsemblGRCm38mm10GRCm38
MGSCv377135,110,993 - 135,125,546 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367127,758,702 - 127,773,179 (+)NCBIMGSCv36mm8
Celera7127,802,588 - 127,817,000 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.87NCBI
FUS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21834,387,522 - 34,399,526 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11639,188,920 - 39,200,929 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01623,775,389 - 23,786,881 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11631,551,035 - 31,562,494 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1631,551,135 - 31,562,327 (+)Ensemblpanpan1.1panPan2
FUS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1617,059,904 - 17,071,227 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl617,060,061 - 17,071,178 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha618,635,210 - 18,646,537 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0617,190,782 - 17,202,115 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl617,190,642 - 17,202,069 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1616,990,989 - 17,002,315 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0616,910,098 - 16,921,413 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0617,222,097 - 17,233,413 (-)NCBIUU_Cfam_GSD_1.0
Fus
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344125,431,822 - 125,442,925 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650113,529,803 - 13,540,764 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650113,529,732 - 13,541,102 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FUS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl317,314,332 - 17,326,637 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1317,314,936 - 17,326,663 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2317,545,614 - 17,557,346 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FUS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1527,870,456 - 27,881,563 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl527,870,330 - 27,882,145 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660681,582,582 - 1,594,493 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fus
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478214,211,294 - 14,223,698 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fus
27 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:168
Count of miRNA genes:133
Interacting mature miRNAs:145
Transcripts:ENSRNOT00000031891
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
61378Bp43Blood pressure QTL 4322.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1181746937196383668Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169112897197261052Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1174133260196383668Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1166532971191278129Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
2325725Eae31Experimental allergic encephalomyelitis QTL 31nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1178810256188377506Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat

Markers in Region
RH130052  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,590,207 - 182,590,401 (+)MAPPERmRatBN7.2
Rnor_6.01199,426,496 - 199,426,689NCBIRnor6.0
Rnor_5.01206,449,214 - 206,449,407UniSTSRnor5.0
RGSC_v3.41187,264,533 - 187,264,726UniSTSRGSC3.4
Celera1180,241,266 - 180,241,459UniSTS
Cytogenetic Map1q36UniSTS
RH137118  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,587,365 - 182,587,559 (+)MAPPERmRatBN7.2
Rnor_6.01199,423,654 - 199,423,847NCBIRnor6.0
Rnor_5.01206,446,372 - 206,446,565UniSTSRnor5.0
RGSC_v3.41187,261,691 - 187,261,884UniSTSRGSC3.4
Celera1180,238,424 - 180,238,617UniSTS
Cytogenetic Map1q36UniSTS


Genetic Models
This gene Fus is modified in the following models/strains:


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 48 33 19 33 1 4 74 34 41 11 1
Low 8 9 8 8 7 7 1 7
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000031891   ⟹   ENSRNOP00000033029
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1182,576,545 - 182,590,414 (+)Ensembl
Rnor_6.0 Ensembl1199,412,834 - 199,426,702 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098752   ⟹   ENSRNOP00000094078
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1182,576,545 - 182,590,414 (+)Ensembl
RefSeq Acc Id: NM_001012137   ⟹   NP_001012137
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81192,007,016 - 192,020,887 (+)NCBI
mRatBN7.21182,576,545 - 182,590,417 (+)NCBI
Rnor_6.01199,412,834 - 199,426,705 (+)NCBI
Rnor_5.01206,435,510 - 206,449,423 (+)NCBI
RGSC_v3.41187,250,871 - 187,264,742 (+)RGD
Celera1180,227,600 - 180,241,475 (+)RGD
Sequence:
RefSeq Acc Id: XM_006230290   ⟹   XP_006230352
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81192,007,011 - 192,020,887 (+)NCBI
mRatBN7.21182,576,479 - 182,590,417 (+)NCBI
Rnor_6.01199,412,805 - 199,426,705 (+)NCBI
Rnor_5.01206,435,510 - 206,449,423 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063265634   ⟹   XP_063121704
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81192,011,327 - 192,020,887 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001012137 (Get FASTA)   NCBI Sequence Viewer  
  XP_006230352 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121704 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH87153 (Get FASTA)   NCBI Sequence Viewer  
  EDM17204 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000033029
  ENSRNOP00000033029.4
  ENSRNOP00000094078.1
RefSeq Acc Id: NP_001012137   ⟸   NM_001012137
- UniProtKB: Q5PQK2 (UniProtKB/TrEMBL),   F7FDP3 (UniProtKB/TrEMBL),   A6I9X8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230352   ⟸   XM_006230290
- Peptide Label: isoform X1
- UniProtKB: A6I9X8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000033029   ⟸   ENSRNOT00000031891
RefSeq Acc Id: ENSRNOP00000094078   ⟸   ENSRNOT00000098752
RefSeq Acc Id: XP_063121704   ⟸   XM_063265634
- Peptide Label: isoform X2
Protein Domains
RanBP2-type   RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5PQK2-F1-model_v2 AlphaFold Q5PQK2 1-518 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690448
Promoter ID:EPDNEW_R973
Type:single initiation site
Name:Fus_1
Description:FUS RNA binding protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01199,412,828 - 199,412,888EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308864 AgrOrtholog
BioCyc Gene G2FUF-57326 BioCyc
Ensembl Genes ENSRNOG00000023360 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000031891 ENTREZGENE
  ENSRNOT00000031891.5 UniProtKB/TrEMBL
  ENSRNOT00000098752.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/TrEMBL
  Zinc finger, RanBP2-type UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7132489 IMAGE-MGC_LOAD
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  RRM_RNP1 UniProtKB/TrEMBL
  TET_fam UniProtKB/TrEMBL
  Znf_RanBP2 UniProtKB/TrEMBL
  Znf_RanBP2_sf UniProtKB/TrEMBL
KEGG Report rno:317385 UniProtKB/TrEMBL
MGC_CLONE MGC:95219 IMAGE-MGC_LOAD
NCBI Gene 317385 ENTREZGENE
PANTHER PTHR23238 UniProtKB/TrEMBL
  PTHR23238:SF5 UniProtKB/TrEMBL
Pfam RRM_1 UniProtKB/TrEMBL
  zf-RanBP UniProtKB/TrEMBL
PhenoGen Fus PhenoGen
PROSITE RRM UniProtKB/TrEMBL
  ZF_RANBP2_1 UniProtKB/TrEMBL
  ZF_RANBP2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000023360 RatGTEx
SMART RRM UniProtKB/TrEMBL
  ZnF_RBZ UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/TrEMBL
  SSF90209 UniProtKB/TrEMBL
UniProt A0A8I6AN32_RAT UniProtKB/TrEMBL
  A6I9X8 ENTREZGENE, UniProtKB/TrEMBL
  F7FDP3 ENTREZGENE, UniProtKB/TrEMBL
  Q5PQK2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-05-06 Fus  Fus RNA binding protein  Fus  FUS RNA binding protein  Name changed 629549 APPROVED
2014-05-21 Fus  fused in sarcoma RNA binding protein  Fus  fused in sarcoma  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-01-17 Fus  fused in sarcoma  Fus  fusion (involved in t(12;16) in malignant liposarcoma) (human)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-10-22 Fus  fusion (involved in t(12;16) in malignant liposarcoma) (human)  Fus  fusion, derived from t(12;16) malignant liposarcoma (human)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Fus  fusion, derived from t(12;16) malignant liposarcoma (human)    fusion (involved in t(12;16) in malignant liposarcoma)  Name updated 1299863 APPROVED
2005-12-06 Fus  fusion (involved in t(12;16) in malignant liposarcoma)  Fus_predicted  fusion (involved in t(12;16) in malignant liposarcoma) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Fus_predicted  fusion (involved in t(12;16) in malignant liposarcoma) (predicted)      Symbol and Name status set to approved 70820 APPROVED