Fosl2 (FOS like 2, AP-1 transcription factor subunit) - Rat Genome Database

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Gene: Fosl2 (FOS like 2, AP-1 transcription factor subunit) Rattus norvegicus
Symbol: Fosl2
Name: FOS like 2, AP-1 transcription factor subunit
RGD ID: 2628
Description: Enables DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Involved in several processes, including conditioned taste aversion; response to estradiol; and response to progesterone. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Biomarker of renal carcinoma. Orthologous to human FOSL2 (FOS like 2, AP-1 transcription factor subunit); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FOS like 2, AP-1 trancription factor subunit; Fos like antigen 2; fos-like antigen 2; fos-related antigen 2; FRA-2; Fra2
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2624,297,898 - 24,319,219 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl624,300,956 - 24,320,034 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx624,601,426 - 24,618,764 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0624,917,309 - 24,934,650 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0624,406,268 - 24,423,562 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0625,598,936 - 25,616,995 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl625,598,936 - 25,616,995 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0635,422,541 - 35,440,258 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera623,796,496 - 23,813,256 (-)NCBICelera
Cytogenetic Map6q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-butoxyethanol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butyric acid  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chlorpromazine  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clozapine  (EXP)
cobalt dichloride  (EXP)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dieldrin  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
fluoranthene  (ISO)
formaldehyde  (ISO)
gemcitabine  (ISO)
geraniol  (ISO)
glucose  (ISO)
glycidol  (EXP)
haloperidol  (EXP)
hexadecanoic acid  (ISO)
hydrogen chloride  (ISO)
indometacin  (EXP,ISO)
ionomycin  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
kainic acid  (EXP)
lead(0)  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP)
mechlorethamine  (ISO)
mercury dibromide  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prostaglandin F2alpha  (EXP)
pyrrolidine dithiocarbamate  (ISO)
raloxifene  (ISO)
ranitidine  (EXP)
rimonabant  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
SL-327  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
succimer  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
testosterone  (EXP,ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
torcetrapib  (ISO)
triclosan  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
alveolar secondary septum development  (IEA,ISO)
B cell differentiation  (IEA,ISO)
B cell proliferation  (IEA,ISO)
bone development  (ISO)
bone mineralization  (IEA,ISO)
cartilage development  (ISO)
cell morphogenesis  (IEA,ISO)
chondrocyte differentiation  (IEA,ISO)
chondrocyte proliferation  (IEA,ISO)
circadian rhythm  (IEP)
collagen biosynthetic process  (IEA,ISO)
collagen metabolic process  (ISO)
conditioned taste aversion  (IEP)
fat cell apoptotic process  (IEA,ISO)
fat cell differentiation  (IEA,ISO)
fat pad development  (IEA,ISO)
female pregnancy  (IEP)
gene expression  (IEA,ISO)
glucose homeostasis  (IEA,ISO)
growth plate cartilage development  (IEA,ISO)
homeostasis of number of cells  (ISO)
homeostasis of number of cells within a tissue  (IEA,ISO)
inflammatory response  (ISO)
inflammatory response to antigenic stimulus  (IEA,ISO)
innate immune response  (IEA,ISO)
insulin metabolic process  (IEA,ISO)
keratinocyte development  (IEA,ISO)
lung alveolus development  (ISO)
lung connective tissue development  (IEA,ISO)
lung development  (ISO)
macrophage differentiation  (IEA,ISO)
mucus secretion  (IEA,ISO)
multicellular organism growth  (IEA,ISO)
myofibroblast differentiation  (IEA,ISO)
neutrophil differentiation  (IEA,ISO)
NK T cell differentiation  (IEA,ISO)
ossification  (ISO)
osteoblast differentiation  (IEA,ISO)
osteoclast differentiation  (IEA,ISO)
photoperiodism  (IEP)
positive regulation of DNA-templated transcription  (IDA,ISO)
positive regulation of fibroblast proliferation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation of multicellular organism growth  (IEA,ISO)
regulation of myofibroblast differentiation  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA,IEA,ISO)
response to bleomycin  (IEA,ISO)
response to cAMP  (IEP)
response to cytokine  (IEP)
response to estradiol  (IMP)
response to glucocorticoid  (IEA,ISO)
response to Gram-positive bacterium  (IEA,ISO)
response to hypoxia  (IEA,IMP,ISO)
response to immobilization stress  (IEP)
response to interleukin-13  (IEA,ISO)
response to interleukin-7  (IEA,ISO)
response to leukemia inhibitory factor  (IEA,ISO)
response to light stimulus  (IEP)
response to lipopolysaccharide  (IEA,ISO)
response to mechanical stimulus  (IEP)
response to organic cyclic compound  (IEP)
response to peptide hormone  (IEP)
response to progesterone  (IEP)
response to toxic substance  (IEP)
response to xenobiotic stimulus  (IEA,ISO)
smooth muscle tissue development  (IEA,ISO)
T cell differentiation  (ISO)
T cell receptor signaling pathway  (IEA,ISO)
tissue remodeling  (IEA,ISO)
transcription by RNA polymerase II  (IMP)

Cellular Component


References - curated
# Reference Title Reference Citation
1. Bcl-xL expression and regulation in the progression, recurrence, and cisplatin resistance of oral cancer. Alam M and Mishra R, Life Sci. 2021 Sep 1;280:119705. doi: 10.1016/j.lfs.2021.119705. Epub 2021 Jun 8.
2. Insidious role of nitric oxide in migration/invasion of colon cancer cells by upregulating MMP-2/9 via activation of cGMP-PKG-ERK signaling pathways. Babykutty S, etal., Clin Exp Metastasis. 2012 Jun;29(5):471-92. doi: 10.1007/s10585-012-9464-6. Epub 2012 Mar 15.
3. Circadian expression of transcription factor Fra-2 in the rat pineal gland. Baler R and Klein DC, J Biol Chem 1995 Nov 10;270(45):27319-25.
4. Temporal and regional expression of Fos-related proteins in response to ischemic injury. Butler TL and Pennypacker KR, Brain Res Bull. 2004 Mar 1;63(1):65-73.
5. The transcriptional response to hypoxic insult controlled by FRA-2. Butler TL and Pennypacker KR, Gene Expr. 2005;12(2):61-7.
6. Selective genomic targeting by FRA-2/FOSL2 transcription factor: regulation of the Rgs4 gene is mediated by a variant activator protein 1 (AP-1) promoter sequence/CREB-binding protein (CBP) mechanism. Davies JS, etal., J Biol Chem. 2011 Apr 29;286(17):15227-39. doi: 10.1074/jbc.M110.201996. Epub 2011 Mar 2.
7. Is light-regulated AP-1 binding in the rat suprachiasmatic nucleus gated by the circadian clock? Francois-Bellan AM, etal., Brain Res Mol Brain Res. 2000 Dec 28;85(1-2):161-70.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Adrenergic inducibility of AP-1 binding in the rat pineal gland depends on prior photoperiod. Guillaumond F, etal., J Neurochem 2002 Oct;83(1):157-66.
11. Circadian binding activity of AP-1, a regulator of the arylalkylamine N-acetyltransferase gene in the rat pineal gland, depends on circadian Fra-2, c-Jun, and Jun-D expression and is regulated by the clock's zeitgebers. Guillaumond F, etal., J Neurochem. 2000 Oct;75(4):1398-407.
12. Selective participation of c-Jun with Fra-2/c-Fos promotes aggressive tumor phenotypes and poor prognosis in tongue cancer. Gupta S, etal., Sci Rep. 2015 Nov 19;5:16811. doi: 10.1038/srep16811.
13. Expression of AP-1 family transcription factors in the amygdala during conditioned taste aversion learning: role for Fra-2. Kwon B, etal., Brain Res. 2008 May 1;1207:128-41. Epub 2008 Feb 9.
14. Fos-like antigen 2 (FOSL2) promotes metastasis in colon cancer. Li S, etal., Exp Cell Res. 2018 Dec 15;373(1-2):57-61. doi: 10.1016/j.yexcr.2018.08.016. Epub 2018 Aug 13.
15. Circular RNA hsa_circ_0056836 functions an oncogenic gene in hepatocellular carcinoma through modulating miR-766-3p/FOSL2 axis. Li Z, etal., Aging (Albany NY). 2020 Feb 12;12(3):2485-2497. doi: 10.18632/aging.102756. Epub 2020 Feb 12.
16. Long noncoding RNA AFAP1-AS1 acts as a competing endogenous RNA of miR-423-5p to facilitate nasopharyngeal carcinoma metastasis through regulating the Rho/Rac pathway. Lian Y, etal., J Exp Clin Cancer Res. 2018 Oct 16;37(1):253. doi: 10.1186/s13046-018-0918-9.
17. Increased susceptibility to transcriptional changes with novel stressor in adrenal medulla of rats exposed to prolonged cold stress. Liu X, etal., Brain Res Mol Brain Res. 2005 Nov 18;141(1):19-29. Epub 2005 Sep 19.
18. Circ-FAT1 Up-Regulates FOSL2 Expression by Sponging miR-619-5p to Facilitate Colorectal Cancer Progression. Ma W, etal., Biochem Genet. 2022 Aug;60(4):1362-1379. doi: 10.1007/s10528-021-10148-6. Epub 2022 Jan 16.
19. Impaired activation of AP-1 and altered expression of constituent proteins in rat adrenal during ageing. Medicherla R, etal., Mech Ageing Dev. 2001 Aug;122(11):1169-86.
20. Differential expression of activator protein-1 transcription factors in pregnant rat myometrium. Mitchell JA and Lye SJ, Biol Reprod. 2002 Jul;67(1):240-6.
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. Fos- and Jun-related transcription factors are involved in the signal transduction pathway of mechanical loading in condylar chondrocytes. Papachristou D, etal., Eur J Orthod. 2006 Feb;28(1):20-6. Epub 2005 Dec 22.
23. GOA pipeline RGD automated data pipeline
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Regulation of AP1 (Jun/Fos) factor expression and activation in ovarian granulosa cells. Relation of JunD and Fra2 to terminal differentiation. Sharma SC and Richards JS, J Biol Chem. 2000 Oct 27;275(43):33718-28.
26. Tissue-specific transgenic knockdown of Fos-related antigen 2 (Fra-2) expression mediated by dominant negative Fra-2. Smith M, etal., Mol Cell Biol 2001 Jun;21(11):3704-13.
27. Cyclic AMP-inducible genes respond uniformly to seasonal lighting conditions in the rat pineal gland. Spessert R, etal., Neuroscience. 2006 Dec 1;143(2):607-13. Epub 2006 Sep 8.
28. MiR-133a acts as an anti-oncogene in Hepatocellular carcinoma by inhibiting FOSL2 through TGF-β/Smad3 signaling pathway. Sun L, etal., Biomed Pharmacother. 2018 Nov;107:168-176. doi: 10.1016/j.biopha.2018.07.151. Epub 2018 Aug 6.
29. Activation of the cAMP pathway synergistically increases IL-1-induced IL-6 gene expression in FRTL-5 thyroid cells: involvement of AP-1 transcription factors. Szabo-Fresnais N, etal., Mol Cell Endocrinol. 2008 Mar 12;284(1-2):28-37. Epub 2008 Jan 8.
30. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
31. Gene expression profiling of testosterone and estradiol-17 beta-induced prostatic dysplasia in Noble rats and response to the antiestrogen ICI 182,780. Thompson CJ, etal., Endocrinology 2002 Jun;143(6):2093-105.
32. Overexpression of members of the AP-1 transcriptional factor family from an early stage of renal carcinogenesis and inhibition of cell growth by AP-1 gene antisense oligonucleotides in the Tsc2 gene mutant (Eker) rat model. Urakami S, etal., Biochem Biophys Res Commun. 1997 Dec 8;241(1):24-30.
33. Basic fibroblast growth factor stimulates collagenase-3 promoter activity in osteoblasts through an activator protein-1-binding site. Varghese S, etal., Endocrinology. 2000 Jun;141(6):2185-91.
34. FOSL2 positively regulates TGF-beta1 signalling in non-small cell lung cancer. Wang J, etal., PLoS One. 2014 Nov 6;9(11):e112150. doi: 10.1371/journal.pone.0112150. eCollection 2014.
35. Restraint-induced fra-2 and c-fos expression in the rat forebrain: relationship to stress duration. Weinberg MS, etal., Neuroscience. 2007 Dec 5;150(2):478-86. Epub 2007 Sep 14.
36. Gene expression in the rat cerebral cortex: comparison of recovery sleep and hypnotic-induced sleep. Wisor JP, etal., Neuroscience. 2006 Aug 11;141(1):371-8. Epub 2006 May 11.
37. The differential molecular mechanisms underlying proenkephalin mRNA expression induced by forskolin and phorbol-12-myristic-13-acetate in primary cultured astrocytes. Won JS and Suh HW, Brain Res Mol Brain Res. 2000 Dec 8;84(1-2):41-51.
38. The comparative analysis of proenkephalin mRNA expression induced by cholera toxin and pertussis toxin in primary cultured rat cortical astrocytes. Won JS and Suh HW, Brain Res Mol Brain Res. 2001 Mar 31;88(1-2):83-93.
Additional References at PubMed
PMID:7790908   PMID:7936655   PMID:11460264   PMID:11750070   PMID:13679379   PMID:15299028   PMID:19289495   PMID:19560520   PMID:20513656   PMID:20618447   PMID:21507338   PMID:21820506  
PMID:22585681   PMID:25547114  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2624,297,898 - 24,319,219 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl624,300,956 - 24,320,034 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx624,601,426 - 24,618,764 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0624,917,309 - 24,934,650 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0624,406,268 - 24,423,562 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0625,598,936 - 25,616,995 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl625,598,936 - 25,616,995 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0635,422,541 - 35,440,258 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera623,796,496 - 23,813,256 (-)NCBICelera
Cytogenetic Map6q14NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38228,392,858 - 28,417,317 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl228,392,448 - 28,417,317 (+)EnsemblGRCh38hg38GRCh38
GRCh37228,615,725 - 28,640,184 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36228,469,283 - 28,491,020 (+)NCBINCBI36Build 36hg18NCBI36
Build 34228,527,429 - 28,549,165NCBI
Celera228,460,891 - 28,482,629 (+)NCBICelera
Cytogenetic Map2p23.2NCBI
HuRef228,356,103 - 28,377,836 (+)NCBIHuRef
CHM1_1228,546,510 - 28,568,245 (+)NCBICHM1_1
T2T-CHM13v2.0228,436,151 - 28,460,588 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39532,292,599 - 32,315,184 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl532,293,145 - 32,315,186 (+)EnsemblGRCm39 Ensembl
GRCm38532,136,472 - 32,157,840 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl532,135,801 - 32,157,842 (+)EnsemblGRCm38mm10GRCm38
MGSCv37532,438,845 - 32,460,213 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36532,413,115 - 32,434,421 (+)NCBIMGSCv36mm8
MGSCv36530,804,839 - 30,826,510 (+)NCBIMGSCv36mm8
Celera529,588,696 - 29,629,647 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map517.33NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495546910,297,179 - 10,319,180 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546910,297,179 - 10,319,180 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan12A98,100,630 - 98,125,163 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A28,392,328 - 28,416,838 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A28,485,271 - 28,498,815 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A28,485,613 - 28,498,397 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11722,340,469 - 22,364,994 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1722,341,322 - 22,361,772 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1722,136,634 - 22,160,204 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01722,904,688 - 22,928,247 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1722,904,806 - 22,928,863 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11722,204,175 - 22,227,721 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01722,256,447 - 22,279,983 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01722,372,895 - 22,396,457 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440629266,512,413 - 66,535,167 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364934,304,395 - 4,327,179 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049364934,308,683 - 4,327,102 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl3110,823,666 - 110,843,068 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13110,820,403 - 110,842,903 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23117,487,534 - 117,495,043 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11479,201,128 - 79,222,363 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1479,201,649 - 79,222,373 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604532,919,208 - 32,943,579 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462473810,370,103 - 10,391,623 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473810,370,479 - 10,391,623 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Fosl2
80 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:75
Count of miRNA genes:62
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000071237, ENSRNOT00000074887
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6127574569Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6127574569Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6127574569Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6127574569Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)61653614027261739Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2624,307,470 - 24,307,665 (+)MAPPERmRatBN7.2
Rnor_6.0625,604,094 - 25,604,288NCBIRnor6.0
Rnor_5.0635,427,357 - 35,427,551UniSTSRnor5.0
Celera623,801,570 - 23,801,764UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera623,796,242 - 23,796,440UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 2 8 13 8 21 9
Low 1 43 49 41 19 41 8 11 57 27 18 2 8
Below cutoff 4 2


RefSeq Acc Id: ENSRNOT00000077894   ⟹   ENSRNOP00000070970
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl625,598,936 - 25,616,995 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000107475   ⟹   ENSRNOP00000091217
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl624,300,956 - 24,319,157 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113775   ⟹   ENSRNOP00000089057
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl624,300,956 - 24,320,034 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119558   ⟹   ENSRNOP00000091751
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl624,300,956 - 24,310,481 (-)Ensembl
RefSeq Acc Id: NM_001013146   ⟹   NP_001013164
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.2624,301,862 - 24,319,219 (-)NCBI
Rnor_6.0625,598,936 - 25,616,995 (-)NCBI
Rnor_5.0635,422,541 - 35,440,258 (-)NCBI
Celera623,796,496 - 23,813,256 (-)NCBI
RefSeq Acc Id: NM_012954   ⟹   NP_037086
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.2624,301,862 - 24,319,219 (-)NCBI
Rnor_6.0625,598,936 - 25,616,995 (-)NCBI
Rnor_5.0635,422,541 - 35,440,258 (-)NCBI
Celera623,796,496 - 23,813,256 (-)RGD
RefSeq Acc Id: XM_039111806   ⟹   XP_038967734
Rat AssemblyChrPosition (strand)Source
mRatBN7.2624,297,898 - 24,310,428 (-)NCBI
RefSeq Acc Id: NP_037086   ⟸   NM_012954
- Peptide Label: isoform 1
- UniProtKB: P51145 (UniProtKB/Swiss-Prot),   Q6GXE4 (UniProtKB/Swiss-Prot),   A0A8I6AAS5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001013164   ⟸   NM_001013146
- Peptide Label: isoform 2
- UniProtKB: Q62738 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070970   ⟸   ENSRNOT00000077894
RefSeq Acc Id: XP_038967734   ⟸   XM_039111806
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GJV9 (UniProtKB/TrEMBL),   A0A8I6AAS5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000091217   ⟸   ENSRNOT00000107475
RefSeq Acc Id: ENSRNOP00000089057   ⟸   ENSRNOT00000113775
RefSeq Acc Id: ENSRNOP00000091751   ⟸   ENSRNOT00000119558
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51145-F1-model_v2 AlphaFold P51145 1-326 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2628 AgrOrtholog
BioCyc Gene G2FUF-38372 BioCyc
Ensembl Genes ENSRNOG00000052357 Ensembl
  ENSRNOG00000068412 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000089057 ENTREZGENE
  ENSRNOP00000089057.1 UniProtKB/TrEMBL
  ENSRNOP00000091217.1 UniProtKB/TrEMBL
  ENSRNOP00000091751.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000107475 ENTREZGENE
  ENSRNOT00000107475.1 UniProtKB/TrEMBL
  ENSRNOT00000113775.1 UniProtKB/TrEMBL
  ENSRNOT00000119558.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AP-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25446 UniProtKB/Swiss-Prot
PANTHER PTHR23351 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23351:SF25 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam bZIP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fosl2 PhenoGen
  BZIP_BASIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BRLZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57959 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC219905
UniProt Secondary Q6GXE4 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-01 Fosl2  FOS like 2, AP-1 transcription factor subunit  Fosl2  FOS like 2, AP-1 trancription factor subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-05-11 Fosl2  FOS like 2, AP-1 trancription factor subunit  Fosl2  fos-like antigen 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Fosl2  Fos like antigen 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA and protein are expressed in pineal gland only at night on a circadian basis 632679
gene_expression expressed selectively in the pineal gland 628507
gene_function transcription factor 628507
gene_physical_interaction forms heterodimeric complexes with Jun proteins, which control gene expression through interaction with the activator protein 1 (AP-1) DNA consensus element; also forms heterodimers with some ATF/CREB family members 628507
gene_process regulates the arylalkylamine-N-acetyltransferase (Aanat) an enzyme in the melatonin biosynthetic pathway 628507
gene_process major stable protein expressed over the circadian period 628397
gene_process two gene targets of transcription regulation are type II iodothyronine deiodinase and nectadrin (CD24) 628507
gene_product member of the fos family of transcription factors 632679
gene_product member of the Fos family of transcription factors 628507
gene_protein protein is 42/46 kDa in size 632679
gene_regulation adrenergic-cyclic AMP mediates the regulation 632679
gene_regulation expression is induced by second messengers, including cyclic AMP (cAMP) and Ca2+ 628507
gene_regulation circadian regulation mediated by an adrenergic to cyclic AMP mechanism 632679
gene_regulation mRNA level is proportional to the level ofactivating protein 628507