Arrdc3 (arrestin domain containing 3) - Rat Genome Database

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Pathways
Gene: Arrdc3 (arrestin domain containing 3) Rattus norvegicus
Analyze
Symbol: Arrdc3
Name: arrestin domain containing 3
RGD ID: 1359478
Description: Predicted to enable beta-3 adrenergic receptor binding activity. Predicted to be involved in negative regulation of cold-induced thermogenesis; positive regulation of hippo signaling; and protein transport. Predicted to act upstream of or within several processes, including fat pad development; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway; and negative regulation of locomotion involved in locomotory behavior. Predicted to be located in early endosome and lysosome. Predicted to be active in endosome and plasma membrane. Orthologous to human ARRDC3 (arrestin domain containing 3); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: arrestin domain-containing protein 3; liver regeneration-related protein LRRG00048; LRRGT00048
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2211,137,464 - 11,149,978 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl211,137,460 - 11,149,978 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx218,258,314 - 18,268,034 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0216,357,917 - 16,367,640 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0210,989,854 - 10,999,566 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.028,732,907 - 8,745,445 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl28,732,932 - 8,743,069 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.028,617,733 - 8,630,270 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera27,507,150 - 7,516,860 (+)NCBICelera
Cytogenetic Map2q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2-methylcholine  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
amosite asbestos  (ISO)
amphetamine  (EXP)
ampicillin  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
cadmium sulfate  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dioxygen  (ISO)
diuron  (EXP,ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
glyphosate  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
inulin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoprenaline  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
metformin  (EXP)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP)
ochratoxin A  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pravastatin  (EXP,ISO)
prednisolone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
resorcinol  (ISO)
rotenone  (EXP)
sodium arsenate  (ISO)
sulfadimethoxine  (EXP)
sulindac  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
vinclozolin  (EXP)
zaragozic acid A  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
early endosome  (IEA)
endosome  (IBA,IEA,ISO)
lysosome  (IEA)
plasma membrane  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. null JRS Domain-based curation
3. The arrestin domain-containing 3 protein regulates body mass and energy expenditure. Patwari P, etal., Cell Metab. 2011 Nov 2;14(5):671-83. doi: 10.1016/j.cmet.2011.08.011. Epub 2011 Oct 6.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:23236378   PMID:36154540  


Genomics

Comparative Map Data
Arrdc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2211,137,464 - 11,149,978 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl211,137,460 - 11,149,978 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx218,258,314 - 18,268,034 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0216,357,917 - 16,367,640 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0210,989,854 - 10,999,566 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.028,732,907 - 8,745,445 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl28,732,932 - 8,743,069 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.028,617,733 - 8,630,270 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera27,507,150 - 7,516,860 (+)NCBICelera
Cytogenetic Map2q11NCBI
ARRDC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38591,368,631 - 91,383,317 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl591,368,631 - 91,383,317 (-)EnsemblGRCh38hg38GRCh38
GRCh37590,664,448 - 90,679,134 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36590,700,297 - 90,714,877 (-)NCBINCBI36Build 36hg18NCBI36
Build 34590,700,297 - 90,714,877NCBI
Celera586,566,595 - 86,581,203 (-)NCBICelera
Cytogenetic Map5q14.3NCBI
HuRef585,876,398 - 85,891,271 (-)NCBIHuRef
CHM1_1590,097,255 - 90,111,863 (-)NCBICHM1_1
T2T-CHM13v2.0591,852,479 - 91,867,169 (-)NCBIT2T-CHM13v2.0
Arrdc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391381,031,508 - 81,044,161 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1381,031,503 - 81,044,161 (+)EnsemblGRCm39 Ensembl
GRCm381380,883,384 - 80,896,042 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1380,883,384 - 80,896,042 (+)EnsemblGRCm38mm10GRCm38
MGSCv371381,022,683 - 81,035,303 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361381,347,107 - 81,359,733 (+)NCBIMGSCv36mm8
Celera1383,148,553 - 83,161,173 (+)NCBICelera
Cytogenetic Map13C2NCBI
cM Map1341.95NCBI
Arrdc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541820,538,983 - 20,548,862 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541820,538,858 - 20,550,876 (+)NCBIChiLan1.0ChiLan1.0
ARRDC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1522,169,817 - 22,184,396 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0523,991,325 - 24,005,913 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1524,126,407 - 24,140,858 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl524,126,427 - 24,140,858 (+)Ensemblpanpan1.1panPan2
ARRDC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1317,691,631 - 17,705,507 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl317,691,961 - 17,703,308 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha319,060,400 - 19,074,268 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0317,596,484 - 17,610,370 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl317,596,591 - 17,610,370 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1317,567,848 - 17,581,735 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0317,537,838 - 17,551,679 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0317,822,875 - 17,836,765 (+)NCBIUU_Cfam_GSD_1.0
Arrdc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213173,248,294 - 173,261,323 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364699,364,347 - 9,377,501 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049364699,364,291 - 9,377,504 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARRDC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl298,430,465 - 98,444,647 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1298,430,451 - 98,444,835 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22101,569,570 - 101,583,907 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARRDC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1485,286,243 - 85,301,208 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl485,286,173 - 85,301,202 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604934,348,931 - 34,363,917 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arrdc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474310,333,693 - 10,346,272 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474310,334,114 - 10,346,030 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Arrdc3
25 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:17
Count of miRNA genes:14
Interacting mature miRNAs:16
Transcripts:ENSRNOT00000072849
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
731166Mamtr2Mammary tumor resistance QTL 20.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777212654247Rat
61368Mcs1Mammary carcinoma susceptibility QTL 14.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777223319447Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 42 57 41 19 41 8 9 74 35 41 11 8
Low 1 1 2
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000072849   ⟹   ENSRNOP00000067658
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl211,137,460 - 11,146,306 (+)Ensembl
Rnor_6.0 Ensembl28,732,932 - 8,743,069 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106948   ⟹   ENSRNOP00000078331
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl211,137,464 - 11,149,978 (+)Ensembl
RefSeq Acc Id: NM_001007797   ⟹   NP_001007798
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2211,137,464 - 11,149,978 (+)NCBI
Rnor_6.028,733,167 - 8,742,871 (+)NCBI
Rnor_5.028,617,733 - 8,630,270 (+)NCBI
Celera27,507,150 - 7,516,860 (+)RGD
Sequence:
RefSeq Acc Id: NR_178214
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2211,137,464 - 11,149,978 (+)NCBI
RefSeq Acc Id: XM_017590815   ⟹   XP_017446304
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2211,140,246 - 11,149,978 (+)NCBI
Rnor_6.028,735,217 - 8,745,445 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039102160   ⟹   XP_038958088
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2211,140,193 - 11,149,978 (+)NCBI
RefSeq Acc Id: XM_039102161   ⟹   XP_038958089
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2211,141,414 - 11,149,978 (+)NCBI
RefSeq Acc Id: NP_001007798   ⟸   NM_001007797
- UniProtKB: Q6TXF1 (UniProtKB/Swiss-Prot),   A6I4I1 (UniProtKB/TrEMBL),   A0A8L2QZ95 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446304   ⟸   XM_017590815
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000067658   ⟸   ENSRNOT00000072849
RefSeq Acc Id: XP_038958088   ⟸   XM_039102160
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038958089   ⟸   XM_039102161
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000078331   ⟸   ENSRNOT00000106948
Protein Domains
Arrestin C-terminal-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6TXF1-F1-model_v2 AlphaFold Q6TXF1 1-414 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359478 AgrOrtholog
BioCyc Gene G2FUF-55032 BioCyc
Ensembl Genes ENSRNOG00000045649 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000067658.2 UniProtKB/TrEMBL
  ENSRNOP00000078331 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000072849.3 UniProtKB/TrEMBL
  ENSRNOT00000106948 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.640 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Arrestin-like_C UniProtKB/TrEMBL
  Arrestin-like_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arrestin_C UniProtKB/Swiss-Prot
  Arrestin_C-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_E-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:309945 UniProtKB/Swiss-Prot
NCBI Gene 309945 ENTREZGENE
PANTHER ARRESTIN DOMAIN CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARRESTIN DOMAIN-CONTAINING PROTEIN 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Arrestin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arrestin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Arrdc3 PhenoGen
SMART Arrestin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81296 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2QZ95 ENTREZGENE, UniProtKB/TrEMBL
  A6I4I1 ENTREZGENE, UniProtKB/TrEMBL
  ARRD3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-07-29 Arrdc3  arrestin domain containing 3      Symbol and Name status set to provisional 70820 PROVISIONAL