Gna15 (G protein subunit alpha 15) - Rat Genome Database

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Gene: Gna15 (G protein subunit alpha 15) Rattus norvegicus
Analyze
Symbol: Gna15
Name: G protein subunit alpha 15
RGD ID: 619751
Description: Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to be part of heterotrimeric G-protein complex. Orthologous to human GNA15 (G protein subunit alpha 15); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; eicosanoid signaling pathway; endothelin signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: g alpha-15; G-protein subunit alpha-15; guanine nucleotide binding protein, alpha 15; guanine nucleotide-binding protein subunit alpha-15; heterotrimeric guanine nucleotide-binding protein 1l; Hg1l
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.278,184,632 - 8,205,508 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,184,861 - 8,205,508 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,070,892 - 11,091,537 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0712,946,556 - 12,967,020 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0710,813,533 - 10,834,132 (+)NCBIRnor_WKY
Rnor_6.0711,054,249 - 11,075,152 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,054,333 - 11,077,251 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,221,467 - 11,242,341 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.479,669,956 - 9,689,442 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.179,669,955 - 9,689,442 (+)NCBI
Celera76,375,600 - 6,396,028 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Identification of two alpha-subunit species of GTP-binding proteins, Galpha15 and Galphaq, expressed in rat taste buds. Kusakabe Y, etal., Biochim Biophys Acta 1998 Jul 24;1403(3):265-72.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Regulation of phosphoinositide-specific phospholipase C. Rhee SG Annu Rev Biochem. 2001;70:281-312.
Additional References at PubMed
PMID:10571060   PMID:10629036  


Genomics

Comparative Map Data
Gna15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.278,184,632 - 8,205,508 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,184,861 - 8,205,508 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,070,892 - 11,091,537 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0712,946,556 - 12,967,020 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0710,813,533 - 10,834,132 (+)NCBIRnor_WKY
Rnor_6.0711,054,249 - 11,075,152 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,054,333 - 11,077,251 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,221,467 - 11,242,341 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.479,669,956 - 9,689,442 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.179,669,955 - 9,689,442 (+)NCBI
Celera76,375,600 - 6,396,028 (+)NCBICelera
Cytogenetic Map7q11NCBI
GNA15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38193,136,033 - 3,163,749 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl193,136,033 - 3,163,749 (+)EnsemblGRCh38hg38GRCh38
GRCh37193,136,031 - 3,163,747 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36193,087,191 - 3,114,766 (+)NCBINCBI36Build 36hg18NCBI36
Build 34193,087,229 - 3,114,741NCBI
Celera193,072,520 - 3,100,641 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef192,905,020 - 2,932,757 (+)NCBIHuRef
CHM1_1193,136,066 - 3,163,645 (+)NCBICHM1_1
T2T-CHM13v2.0193,111,823 - 3,140,075 (+)NCBIT2T-CHM13v2.0
Gna15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391081,338,147 - 81,360,283 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1081,338,140 - 81,360,059 (-)EnsemblGRCm39 Ensembl
GRCm381081,502,313 - 81,524,447 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,502,306 - 81,524,225 (-)EnsemblGRCm38mm10GRCm38
MGSCv371080,965,058 - 80,986,970 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361080,905,442 - 80,927,354 (-)NCBIMGSCv36mm8
Celera1082,525,696 - 82,547,406 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Gna15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554955,252,547 - 5,270,894 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554955,254,546 - 5,270,864 (-)NCBIChiLan1.0ChiLan1.0
GNA15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1196,766,714 - 6,794,947 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0192,163,773 - 2,191,985 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1193,116,969 - 3,146,118 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl193,116,969 - 3,146,118 (+)Ensemblpanpan1.1panPan2
GNA15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12056,117,398 - 56,129,251 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2056,118,067 - 56,126,502 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2055,841,262 - 55,861,721 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02056,776,099 - 56,796,565 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2056,776,384 - 56,795,993 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12055,831,499 - 55,851,940 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02056,315,605 - 56,336,066 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02056,514,343 - 56,534,807 (-)NCBIUU_Cfam_GSD_1.0
Gna15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118216,017,998 - 216,030,469 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365881,804,231 - 1,816,782 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365881,802,576 - 1,816,772 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNA15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl275,408,724 - 75,433,814 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1275,408,723 - 75,433,809 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2275,928,409 - 75,949,083 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GNA15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.162,901,502 - 2,930,567 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl62,901,762 - 2,932,138 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660815,652,079 - 5,680,809 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gna15
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248286,046,186 - 6,063,330 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248286,048,697 - 6,062,851 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gna15
105 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:55
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000007202
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat

Markers in Region
RH130909  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,205,283 - 8,205,463 (+)MAPPERmRatBN7.2
Rnor_6.0711,074,928 - 11,075,107NCBIRnor6.0
Rnor_5.0711,242,117 - 11,242,296UniSTSRnor5.0
RGSC_v3.479,689,226 - 9,689,405UniSTSRGSC3.4
Celera76,395,812 - 6,395,991UniSTS
Cytogenetic Map7q11UniSTS
RH143612  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,197,278 - 8,197,554 (+)MAPPERmRatBN7.2
Rnor_6.0711,066,924 - 11,067,199NCBIRnor6.0
Rnor_5.0711,234,113 - 11,234,388UniSTSRnor5.0
RGSC_v3.479,681,222 - 9,681,497UniSTSRGSC3.4
Celera76,387,828 - 6,388,103UniSTS
Cytogenetic Map7q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 1
Low 3 19 54 38 13 38 8 10 46 29 30 11 8
Below cutoff 18 3 3 3 1 26 6 10

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007202   ⟹   ENSRNOP00000007202
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,184,861 - 8,205,508 (+)Ensembl
Rnor_6.0 Ensembl711,054,333 - 11,077,251 (+)Ensembl
RefSeq Acc Id: NM_053542   ⟹   NP_445994
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,184,861 - 8,205,508 (+)NCBI
Rnor_6.0711,054,632 - 11,075,144 (+)NCBI
Rnor_5.0711,221,467 - 11,242,341 (+)NCBI
RGSC_v3.479,669,956 - 9,689,442 (+)RGD
Celera76,375,600 - 6,396,028 (+)RGD
Sequence:
RefSeq Acc Id: XM_006241021   ⟹   XP_006241083
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,184,642 - 8,205,508 (+)NCBI
Rnor_6.0711,054,249 - 11,075,152 (+)NCBI
Rnor_5.0711,221,467 - 11,242,341 (+)NCBI
Sequence:
RefSeq Acc Id: XR_005486732
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,184,632 - 8,205,508 (+)NCBI
Protein Sequences
Protein RefSeqs NP_445994 (Get FASTA)   NCBI Sequence Viewer  
  XP_006241083 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA28827 (Get FASTA)   NCBI Sequence Viewer  
  CAG9553617 (Get FASTA)   NCBI Sequence Viewer  
  EDL89143 (Get FASTA)   NCBI Sequence Viewer  
  O88302 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_445994   ⟸   NM_053542
- UniProtKB: G3V6N8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241083   ⟸   XM_006241021
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000007202   ⟸   ENSRNOT00000007202
Protein Domains
G-alpha

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88302-F1-model_v2 AlphaFold O88302 1-374 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619751 AgrOrtholog
BioCyc Gene G2FUF-35038 BioCyc
Ensembl Genes ENSRNOG00000005378 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000007202 ENTREZGENE
  ENSRNOP00000007202.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007202 ENTREZGENE
  ENSRNOT00000007202.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.400.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Gprotein_alpha_Q UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gprotein_alpha_su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GproteinA_insert UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:89788 UniProtKB/Swiss-Prot
NCBI Gene 89788 ENTREZGENE
PANTHER GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10218 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam G-alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gna15 PhenoGen
PRINTS GPROTEINA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPROTEINAQ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART G_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G3V6N8 ENTREZGENE, UniProtKB/TrEMBL
  GNA15_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-07 Gna15  G protein subunit alpha 15  Gna15  guanine nucleotide binding protein, alpha 15  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Gna15  guanine nucleotide binding protein, alpha 15      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Gna15  guanine nucleotide binding protein, alpha 15      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression protein localized mainly to taste buds 728647
gene_homology shares aa sequence similarity of 94% with mouse Gna15 728647
gene_process may be involved in taste signal transduction 728647