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Gene: Zbtb44 (zinc finger and BTB domain containing 44) Rattus norvegicus
Analyze
Symbol:
Zbtb44
Name:
zinc finger and BTB domain containing 44
RGD ID:
1308984
Description:
Predicted to have DNA binding activity and metal ion binding activity. Predicted to localize to nucleus. Orthologous to human ZBTB44 (zinc finger and BTB domain containing 44); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A; cobalt dichloride.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
BTB (POZ) domain containing 15; BTB/POZ domain-containing protein 15; Btbd15; LOC363035; MGC125242; RGD1308984; similar to RIKEN cDNA 6030404E16; zinc finger and BTB domain-containing protein 44
RGD Orthologs
Alliance Genes
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
ZBTB44 (zinc finger and BTB domain containing 44)
HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Zbtb44 (zinc finger and BTB domain containing 44)
HGNC
Treefam, EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Zbtb44 (zinc finger and BTB domain containing 44)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
ZBTB44 (zinc finger and BTB domain containing 44)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
ZBTB44 (zinc finger and BTB domain containing 44)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Zbtb44 (zinc finger and BTB domain containing 44)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
ZBTB44 (zinc finger and BTB domain containing 44)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
ZBTB44 (zinc finger and BTB domain containing 44)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Zbtb44 (zinc finger and BTB domain containing 44)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
Zbtb44 (zinc finger and BTB domain containing 44)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Homo sapiens (human):
ZBTB44 (zinc finger and BTB domain containing 44)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Danio rerio (zebrafish):
zbtb44 (zinc finger and BTB domain containing 44)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Drosophila melanogaster (fruit fly):
CG31224
Alliance
DIOPT (Ensembl Compara|PANTHER)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl mRatBN7.2 8 29,466,055 - 29,524,027 (+) NCBI Rnor_6.0 Ensembl 8 32,165,810 - 32,217,476 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_6.0 8 32,165,388 - 32,223,341 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_5.0 8 32,191,422 - 32,248,945 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 8 30,841,899 - 30,894,133 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 8 30,850,442 - 30,921,405 (+) NCBI Celera 8 30,928,937 - 30,979,901 (+) NCBI Celera Cytogenetic Map 8 q13 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Disease Annotations - ClinVar
(-)-demecolcine decreases expression ISO RGD:1606019 6480464 Demecolcine results in decreased expression of ZBTB44 mRNA CTD PMID:23649840 1,2-dichloroethane decreases expression ISO RGD:1552909 6480464 ethylene dichloride results in decreased expression of ZBTB44 mRNA CTD PMID:28189721 1,2-dichloroethane affects expression ISO RGD:1552909 6480464 ethylene dichloride affects the expression of ZBTB44 mRNA CTD PMID:28960355 1,2-dimethylhydrazine decreases expression ISO RGD:1552909 6480464 1, 2-Dimethylhydrazine results in decreased expression of ZBTB44 mRNA CTD PMID:22206623 2,3,7,8-Tetrachlorodibenzofuran increases expression EXP 6480464 2 more ... CTD PMID:32109520 3,3',4,4'-tetrachlorobiphenyl multiple interactions ISO RGD:1552909 6480464 3 more ... CTD PMID:19467301 aflatoxin B1 increases methylation ISO RGD:1606019 6480464 Aflatoxin B1 results in increased methylation of ZBTB44 intron CTD PMID:30157460 aflatoxin B1 decreases methylation ISO RGD:1606019 6480464 Aflatoxin B1 results in decreased methylation of ZBTB44 exon CTD PMID:30157460 antirheumatic drug increases expression ISO RGD:1606019 6480464 Antirheumatic Agents results in increased expression of ZBTB44 mRNA CTD PMID:24449571 arsane affects methylation ISO RGD:1606019 6480464 Arsenic affects the methylation of ZBTB44 gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:1606019 6480464 Arsenic affects the methylation of ZBTB44 gene CTD PMID:25304211 avobenzone increases expression ISO RGD:1606019 6480464 avobenzone results in increased expression of ZBTB44 mRNA CTD PMID:31016361 benzo[a]pyrene affects methylation ISO RGD:1606019 6480464 Benzoapyrene affects the methylation of ZBTB44 intron CTD PMID:30157460 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1606019 6480464 7 more ... CTD PMID:19150397 benzo[e]pyrene decreases methylation ISO RGD:1606019 6480464 benzoepyrene results in decreased methylation of ZBTB44 exon CTD PMID:30157460 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of ZBTB44 mRNA CTD PMID:33296240 butanal decreases expression ISO RGD:1606019 6480464 butyraldehyde results in decreased expression of ZBTB44 mRNA CTD PMID:26079696 carbon nanotube decreases expression ISO RGD:1552909 6480464 Nanotubes more ... CTD PMID:25554681 cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of ZBTB44 mRNA CTD PMID:24386269 cyclosporin A decreases expression ISO RGD:1606019 6480464 Cyclosporine results in decreased expression of ZBTB44 mRNA CTD PMID:25562108 dibutyl phthalate increases expression ISO RGD:1552909 6480464 Dibutyl Phthalate results in increased expression of ZBTB44 mRNA CTD PMID:21266533 dioxygen multiple interactions ISO RGD:1552909 6480464 Oxygen inhibits the reaction [Oxygen deficiency results in increased expression of ZBTB44 mRNA] CTD PMID:22629407 dioxygen increases expression ISO RGD:1552909 6480464 Oxygen deficiency results in increased expression of ZBTB44 mRNA CTD PMID:22629407 disodium selenite increases expression ISO RGD:1606019 6480464 Sodium Selenite results in increased expression of ZBTB44 mRNA CTD PMID:24383545 diuron increases expression EXP 6480464 Diuron results in increased expression of ZBTB44 mRNA CTD PMID:21551480 dorsomorphin multiple interactions ISO RGD:1606019 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-5-benzo1 more ... CTD PMID:27188386 elemental selenium decreases expression ISO RGD:1606019 6480464 Selenium results in decreased expression of ZBTB44 mRNA CTD PMID:19244175 furan increases methylation EXP 6480464 furan results in increased methylation of ZBTB44 gene CTD PMID:22079235 indometacin decreases expression ISO RGD:1606019 6480464 Indomethacin results in decreased expression of ZBTB44 mRNA CTD PMID:16984733 isoprenaline increases expression ISO RGD:1552909 6480464 Isoproterenol results in increased expression of ZBTB44 mRNA CTD PMID:20003209 maneb multiple interactions ISO RGD:1552909 6480464 [Paraquat co-treated with Maneb] affects the expression of ZBTB44 mRNA CTD PMID:22563483 methapyrilene decreases methylation ISO RGD:1606019 6480464 Methapyrilene results in decreased methylation of ZBTB44 exon CTD PMID:30157460 methylmercury chloride decreases expression ISO RGD:1606019 6480464 methylmercuric chloride results in decreased expression of ZBTB44 mRNA CTD PMID:28001369 paracetamol decreases expression ISO RGD:1606019 6480464 Acetaminophen results in decreased expression of ZBTB44 mRNA CTD PMID:21420995 paraquat multiple interactions ISO RGD:1552909 6480464 [Paraquat co-treated with Maneb] affects the expression of ZBTB44 mRNA CTD PMID:22563483 paraquat increases expression ISO RGD:1552909 6480464 Paraquat results in increased expression of ZBTB44 mRNA CTD PMID:22563483 phenacetin decreases expression EXP 6480464 Phenacetin results in decreased expression of ZBTB44 mRNA CTD PMID:17082564 phenobarbital affects expression ISO RGD:1552909 6480464 Phenobarbital affects the expression of ZBTB44 mRNA CTD PMID:23091169 phenylhydrazine decreases expression EXP 6480464 phenylhydrazine results in decreased expression of ZBTB44 mRNA CTD PMID:17082564 phenylmercury acetate increases expression ISO RGD:1606019 6480464 Phenylmercuric Acetate results in increased expression of ZBTB44 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:1606019 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in increased expression of ZBTB44 mRNA CTD PMID:27188386 PhIP increases expression EXP 6480464 2-amino-1-methyl-6-phenylimidazo4, 5-bpyridine results in increased expression of ZBTB44 mRNA CTD PMID:15215175 pinosylvin decreases expression ISO RGD:1606019 6480464 pinosylvin results in decreased expression of ZBTB44 mRNA CTD PMID:23333577 pirinixic acid increases expression ISO RGD:1552909 6480464 pirinixic acid results in increased expression of ZBTB44 mRNA CTD PMID:18301758 , PMID:23811191 propiconazole decreases expression ISO RGD:1552909 6480464 propiconazole results in decreased expression of ZBTB44 mRNA CTD PMID:21278054 pyridaben increases expression ISO RGD:1552909 6480464 pyridaben results in increased expression of ZBTB44 mRNA CTD PMID:22563483 SB 431542 multiple interactions ISO RGD:1606019 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-5-benzo1 more ... CTD PMID:27188386 selenium atom decreases expression ISO RGD:1606019 6480464 Selenium results in decreased expression of ZBTB44 mRNA CTD PMID:19244175 sodium arsenite affects methylation ISO RGD:1606019 6480464 sodium arsenite affects the methylation of ZBTB44 gene CTD PMID:28589171 sunitinib increases expression ISO RGD:1606019 6480464 Sunitinib results in increased expression of ZBTB44 mRNA CTD PMID:31533062 trans-pinosylvin decreases expression ISO RGD:1606019 6480464 pinosylvin results in decreased expression of ZBTB44 mRNA CTD PMID:23333577 triptonide decreases expression ISO RGD:1552909 6480464 triptonide results in decreased expression of ZBTB44 mRNA CTD PMID:33045310 troglitazone decreases expression ISO RGD:1552909 6480464 troglitazone results in decreased expression of ZBTB44 mRNA CTD PMID:28973697 urethane increases expression ISO RGD:1606019 6480464 Urethane results in increased expression of ZBTB44 mRNA CTD PMID:28818685 valproic acid affects expression ISO RGD:1606019 6480464 Valproic Acid affects the expression of ZBTB44 mRNA CTD PMID:25979313 valproic acid multiple interactions ISO RGD:1606019 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in decreased expression of ZBTB44 mRNA CTD PMID:27188386 valproic acid decreases expression ISO RGD:1606019 6480464 Valproic Acid results in decreased expression of ZBTB44 mRNA CTD PMID:23179753 more ... valproic acid affects splicing EXP 6480464 Valproic Acid affects the splicing of ZBTB44 mRNA CTD PMID:29427782
Cellular Component
nucleus located_in IEA UniProtKB-SubCell:SL-0191 1600115 GO_REF:0000044 UniProt GO_REF:0000044
References
Additional References at PubMed
Genomics
QTLs in Region (Rnor_6.0)
12880023 Bw184 Body weight QTL 184 0.001 body mass (VT:0001259) body weight (CMO:0000012) 8 2108128 47108128 Rat 12880025 Cm102 Cardiac mass QTL 102 0.044 heart mass (VT:0007028) heart wet weight to body weight ratio (CMO:0002408) 8 2108128 47108128 Rat 12880028 Cm103 Cardiac mass QTL 103 0.02 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) 8 2108128 47108128 Rat 12880044 Am9 Aortic mass QTL 9 0.007 aorta mass (VT:0002845) aorta weight to aorta length to body weight ratio (CMO:0002722) 8 2108128 47108128 Rat 2317032 Ginf2 Gastrointestinal inflammation QTL 2 3.21 0.005 liver integrity trait (VT:0010547) liver granuloma severity score (CMO:0002157) 8 7368076 52368076 Rat 2317036 Livw3 Liver weight QTL 3 2.43 0.01 liver mass (VT:0003402) liver weight to body weight ratio (CMO:0000633) 8 7368076 52368076 Rat 2317048 Ginf1 Gastrointestinal inflammation QTL 1 3.52 0.005 cecum mucosa thickness (VT:0010234) enterocolitis severity score (CMO:0002138) 8 7368076 52368076 Rat 2301416 Bp315 Blood pressure QTL 315 0.008 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 8 8738677 53738677 Rat 1581557 Eae16 Experimental allergic encephalomyelitis QTL 16 3.8 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046) 8 9531047 119211942 Rat 1354627 Despr14 Despair related QTL 14 0.0056 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) 8 10388439 55388439 Rat 1354595 Despr4 Despair related QTL 4 2.16 0.0036 locomotor behavior trait (VT:0001392) amount of time spent in voluntary immobility (CMO:0001043) 8 10388439 55388439 Rat 631650 Stl6 Serum triglyceride level QTL 6 4 0.0019 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) 8 10938911 120496129 Rat 1598824 Memor4 Memory QTL 4 2.5 exploratory behavior trait (VT:0010471) total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443) 8 11373267 57541668 Rat 1357398 Slep3 Serum leptin concentration QTL 3 3.43 blood leptin amount (VT:0005667) serum leptin level (CMO:0000780) 8 11373509 45712344 Rat 2302367 Slep5 Serum leptin concentration QTL 5 3.43 blood leptin amount (VT:0005667) serum leptin level (CMO:0000780) 8 11373509 45712344 Rat 2317030 Wbc5 White blood cell count QTL 5 3.21 0.005 leukocyte quantity (VT:0000217) white blood cell count (CMO:0000027) 8 11448251 56448251 Rat 2317051 Aia18 Adjuvant induced arthritis QTL 18 2.42 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) 8 11448251 56448251 Rat 1558646 Swd5 Spike wave discharge measurement QTL 5 3.45 0.00036 brain electrophysiology trait (VT:0010557) brain spike-and-wave discharge frequency (CMO:0001742) 8 17666555 62666555 Rat 61373 Mcs4 Mammary carcinoma susceptibility QTL 4 1.1 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) 8 20717592 65717592 Rat 631271 Lecl1 Lens clarity QTL 1 0.001 lens clarity trait (VT:0001304) age of onset/diagnosis of cataract (CMO:0001584) 8 21464919 91140553 Rat 731182 Uae24 Urinary albumin excretion QTL 24 6.4 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 8 21813070 100873963 Rat 631842 Inf1 Infertility severity QTL 1 4.1 0.001 seminal gland mass (VT:0010524) seminal vesicle wet weight (CMO:0001603) 8 27841496 72841496 Rat 1359021 Bp271 Blood pressure QTL 271 1.8 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 8 28168023 50708951 Rat 631648 Stl5 Serum triglyceride level QTL 5 4 0.0003 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) 8 29867983 59908353 Rat 1358892 Kidm26 Kidney mass QTL 26 3.69 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) 8 29867983 106526740 Rat 1358896 Bp262 Blood pressure QTL 262 2.89 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 8 29867983 106526740 Rat 1358907 Cm40 Cardiac mass QTL 40 1.89 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) 8 29867983 106526740 Rat 2303564 Gluco43 Glucose level QTL 43 3 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 8 30144800 75144800 Rat 2303572 Insul13 Insulin level QTL 13 2 blood insulin amount (VT:0001560) blood insulin level (CMO:0000349) 8 30144800 75144800 Rat 724540 Uae8 Urinary albumin excretion QTL 8 5 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) 8 30845450 33558764 Rat 1331804 Cm30 Cardiac mass QTL 30 3.77443 heart mass (VT:0007028) heart wet weight (CMO:0000069) 8 30918112 58858224 Rat 1300146 Rf17 Renal function QTL 17 2.9 renal blood flow trait (VT:2000006) absolute change in renal blood flow rate (CMO:0001168) 8 30918112 75918112 Rat 8662823 Vetf5 Vascular elastic tissue fragility QTL 5 1.9 artery integrity trait (VT:0010639) patent ductus arteriosus score (CMO:0002566) 8 30918112 107206309 Rat 2302278 Gluco36 Glucose level QTL 36 4.2 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 8 32201981 54065241 Rat 724514 Uae15 Urinary albumin excretion QTL 15 2.9 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 8 32201981 75971421 Rat