Mir133a1 (microRNA 133a-1) - Rat Genome Database

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Gene: Mir133a1 (microRNA 133a-1) Rattus norvegicus
Symbol: Mir133a1
Name: microRNA 133a-1
RGD ID: 2325571
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Predicted to be involved in several processes, including miRNA-mediated gene silencing by mRNA destabilization; negative regulation of low-density lipoprotein particle clearance; and negative regulation of vascular associated smooth muscle cell proliferation. Predicted to act upstream of or within several processes, including cellular response to leukemia inhibitory factor; negative regulation of osteoblast differentiation; and regulation of gene expression. Predicted to be located in extracellular space. Biomarker of gestational diabetes. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human MIR133A1 (microRNA 133a-1); INTERACTS WITH bleomycin A2; cisplatin; perfluorooctane-1-sulfonic acid.
Type: ncrna
Previously known as: microRNA 133a; Mir133a; rno-mir-133a
RGD Orthologs
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8182,157,872 - 2,157,958 (-)NCBIGRCr8
mRatBN7.2181,885,082 - 1,885,168 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx182,114,722 - 2,114,808 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0182,902,423 - 2,902,509 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0182,116,604 - 2,116,690 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0182,052,478 - 2,052,564 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0182,085,457 - 2,085,543 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera181,764,873 - 1,764,959 (-)NCBICelera
Cytogenetic Map18p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. MiR-320a contributes to atherogenesis by augmenting multiple risk factors and down-regulating SRF. Chen C, etal., J Cell Mol Med. 2015 May;19(5):970-85. doi: 10.1111/jcmm.12483. Epub 2015 Feb 27.
2. A conserved MADS-box phosphorylation motif regulates differentiation and mitochondrial function in skeletal, cardiac, and smooth muscle cells. Mughal W, etal., Cell Death Dis. 2015 Oct 29;6:e1944. doi: 10.1038/cddis.2015.306.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. MiR-133a acts as an anti-oncogene in Hepatocellular carcinoma by inhibiting FOSL2 through TGF-β/Smad3 signaling pathway. Sun L, etal., Biomed Pharmacother. 2018 Nov;107:168-176. doi: 10.1016/j.biopha.2018.07.151. Epub 2018 Aug 6.
Additional References at PubMed
PMID:16381832   PMID:17604727   PMID:19015276   PMID:19188439   PMID:20403161   PMID:20439489   PMID:21406115   PMID:21628588   PMID:22000014   PMID:22086007   PMID:24205035   PMID:25451078  
PMID:25465869   PMID:25658461   PMID:26202011   PMID:26334104   PMID:26627004   PMID:26830171   PMID:26845040   PMID:27411382   PMID:27634012   PMID:28000044   PMID:28283551   PMID:28303410  
PMID:28795305   PMID:29178928   PMID:29488353   PMID:30472896   PMID:31646592   PMID:31825931   PMID:32632603   PMID:32713934   PMID:33753579   PMID:34968461  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8182,157,872 - 2,157,958 (-)NCBIGRCr8
mRatBN7.2181,885,082 - 1,885,168 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx182,114,722 - 2,114,808 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0182,902,423 - 2,902,509 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0182,116,604 - 2,116,690 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0182,052,478 - 2,052,564 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0182,085,457 - 2,085,543 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera181,764,873 - 1,764,959 (-)NCBICelera
Cytogenetic Map18p13NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381821,825,698 - 21,825,785 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1821,825,698 - 21,825,785 (-)EnsemblGRCh38hg38GRCh38
GRCh371819,405,659 - 19,405,746 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361817,659,656 - 17,659,743 (-)NCBINCBI36Build 36hg18NCBI36
Celera1816,211,722 - 16,211,809 (-)NCBICelera
Cytogenetic Map18q11.2NCBI
HuRef1816,253,046 - 16,253,133 (-)NCBIHuRef
CHM1_11819,332,764 - 19,332,851 (-)NCBICHM1_1
T2T-CHM13v2.01822,010,746 - 22,010,833 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391810,782,909 - 10,782,976 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1810,782,909 - 10,782,976 (-)EnsemblGRCm39 Ensembl
GRCm381810,782,909 - 10,782,976 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1810,782,909 - 10,782,976 (-)EnsemblGRCm38mm10GRCm38
MGSCv371810,782,907 - 10,782,974 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1810,812,893 - 10,812,960 (-)NCBICelera
Cytogenetic Map18A1NCBI
cM Map185.4NCBI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1766,217,486 - 66,217,572 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl766,217,486 - 66,217,572 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha765,672,066 - 65,672,152 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0766,282,216 - 66,282,302 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1765,948,146 - 65,948,232 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0765,971,074 - 65,971,160 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0766,271,441 - 66,271,527 (+)NCBIUU_Cfam_GSD_1.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl6106,998,896 - 106,998,982 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16106,998,899 - 106,998,971 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2699,485,213 - 99,485,285 (+)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Klf15rno-miR-133a-3pMirtarbaseexternal_infoWestern blotFunctional MTI19720047
Hcn2rno-miR-133a-3pMirtarbaseexternal_infoReporter assay//real-timeRT-PCR//Western blotFunctional MTI17516552
Casp9rno-miR-133a-3pMirtarbaseexternal_infoWestern blotFunctional MTI17715156
Casp9rno-miR-133a-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20056941
Slc2a4rno-miR-133a-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19720047

Predicted Targets
Summary Value
Count of predictions:12021
Count of gene targets:7536
Count of transcripts:8164
Interacting mature miRNAs:rno-miR-133a-3p, rno-miR-133a-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18125758124Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18125758124Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2181,884,892 - 1,885,066 (+)MAPPERmRatBN7.2
Rnor_6.0182,052,289 - 2,052,462NCBIRnor6.0
Rnor_5.0182,085,268 - 2,085,441UniSTSRnor5.0
RGSC_v3.4182,189,027 - 2,189,200UniSTSRGSC3.4
Celera181,764,684 - 1,764,857UniSTS
RH 3.4 Map189.7UniSTS
Cytogenetic Map18p13UniSTS



Nucleotide Sequences
RefSeq Transcripts NR_031879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: NR_031879
Rat AssemblyChrPosition (strand)Source
GRCr8182,157,872 - 2,157,958 (-)NCBI
mRatBN7.2181,885,082 - 1,885,168 (-)NCBI
Rnor_6.0182,052,478 - 2,052,564 (-)NCBI
Rnor_5.0182,085,457 - 2,085,543 (-)NCBI
Celera181,764,873 - 1,764,959 (-)NCBI

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325571 AgrOrtholog
BioCyc Gene G2FUF-8402 BioCyc
miRBase MI0000906 ENTREZGENE
NCBI Gene 100314030 ENTREZGENE
PhenoGen Mir133a1 PhenoGen
RNAcentral URS0000383E7F RNACentral
  URS00004C9052 RNACentral
  URS000075B5D5 RNACentral

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-20 Mir133a1  microRNA 133a-1  Mir133a  microRNA 133a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-04-09 Mir133a  microRNA 133a  Mir133a  microRNA mir-133a  Name updated 61478 APPROVED
2010-06-02 Mir133a  microRNA mir-133a      Symbol and Name status set to provisional 70820 PROVISIONAL