Gene: Syk (spleen associated tyrosine kinase) Rattus norvegicus
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Symbol: Syk
Name: spleen associated tyrosine kinase
Description: Exhibits protein domain specific binding activity, protein tyrosine kinase activity, and ubiquitin protein ligase binding activity; involved in positive regulation of mast cell degranulation and protein autophosphorylation; predicted to localize to several cellular components, including the intracellular organelle and plasma membrane protein complex; used to study anti-basement membrane glomerulonephritis; orthologous to human SYK (spleen associated tyrosine kinase); PARTICIPATES IN eicosanoid signaling pathway; FasL mediated signaling pathway; Fc epsilon receptor mediated signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,6-dinitrotoluene; all-trans-retinoic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: p72syk; spleen tyrosine kinase; tyrosine-protein kinase SYK
Orthologs:
Homo sapiens (human) : SYK (spleen associated tyrosine kinase)  HGNC  Alliance
Mus musculus (house mouse) : Syk (spleen tyrosine kinase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Syk (spleen associated tyrosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : SYK (spleen associated tyrosine kinase)
Canis lupus familiaris (dog) : SYK (spleen associated tyrosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Syk (spleen associated tyrosine kinase)
Sus scrofa (pig) : SYK (spleen associated tyrosine kinase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01712,614,311 - 12,669,568 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01714,703,903 - 14,759,160 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41718,440,672 - 18,498,001 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11718,440,671 - 18,498,006 (-)NCBI
Celera1712,367,624 - 12,424,213 (-)NCBICelera
Cytogenetic Map17p14NCBI
RH 3.4 Map17126.2RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Syk
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3796
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.