biguanide - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	biguanide	go back to main search page
Accession:	CHEBI:3095	browse the term
Definition:	A guanidine that has formula C2H7N5.
Synonyms:	exact_synonym:	1,2,3-triimidodicarbonic diamide
	related_synonym:	Formula=C2H7N5; H2N-C(=NH)-NH-C(=NH)-NH2; Hbig; InChI=1S/C2H7N5/c3-1(4)7-2(5)6/h(H7,3,4,5,6,7); InChIKey=XNCOSPRUTUOJCJ-UHFFFAOYSA-N; SMILES=NC(=N)NC(N)=N; imidodicarbonimidic diamide
	xref:	Beilstein:507183; CAS:56-03-1; Gmelin:240093; KEGG:C07672

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Genes (1136)

chlorhexidine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

decreases activity

Chlorhexidine results in decreased activity of ACHE protein

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

heat shock protein family A (Hsp70) member 5

increases expression

Chlorhexidine results in increased expression of HSPA5 protein

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

iodotyrosine deiodinase

multiple interactions

Chlorhexidine inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine]

NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319

G

solute carrier family 22 member 2

multiple interactions

Chlorhexidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

chlorhexidine gluconate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glutamic--pyruvic transaminase

increases secretion

chlorhexidine gluconate results in increased secretion of GPT protein

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

metformin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetoacetyl-CoA synthetase

increases expression

Metformin results in increased expression of AACS mRNA

NCBI chr12:31,113,098...31,156,411
Ensembl chr12:31,113,098...31,160,954

G

alanyl-tRNA synthetase 1

increases expression

Metformin results in increased expression of AARS1 mRNA

NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147

G

ATP binding cassette subfamily B member 11

decreases expression
multiple interactions

Metformin results in decreased expression of ABCB11 mRNA
[Metformin co-treated with Ethinyl Estradiol] results in decreased expression of ABCB11 protein

PMID:27765674 PMID:34058177

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 1A

multiple interactions
decreases expression

Metformin inhibits the reaction [Doxorubicin results in increased expression of ABCB1 mRNA]; Metformin inhibits the reaction [RELA protein results in increased expression of ABCB1 mRNA]; Metformin inhibits the reaction [TNF protein results in increased expression of ABCB1 mRNA]; Metformin inhibits the reaction [TNF protein results in increased expression of ABCB1 protein]; PRKAA1 protein affects the reaction [Metformin results in decreased expression of ABCB1 protein]
Metformin results in decreased expression of ABCB1 mRNA; Metformin results in decreased expression of ABCB1 protein

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

increases expression

Metformin results in increased expression of ABCB1B mRNA

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily B member 4

increases expression

Metformin results in increased expression of ABCB4 mRNA

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

ATP binding cassette subfamily B member 6

decreases expression

Metformin results in decreased expression of ABCB6 mRNA

NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924

G

ATP binding cassette subfamily B member 9

affects expression

Metformin affects the expression of ABCB9 mRNA

NCBI chr12:32,499,213...32,531,932
Ensembl chr12:32,499,225...32,531,931

G

ATP binding cassette subfamily C member 2

increases expression

Metformin results in increased expression of ABCC2 mRNA

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

decreases expression

Metformin results in decreased expression of ABCC3 mRNA

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily C member 4

multiple interactions

Metformin inhibits the reaction [Ethinyl Estradiol results in increased expression of ABCC4 protein]

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

ATP binding cassette subfamily C member 5

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of ABCC5 mRNA]

NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253

G

ATP binding cassette subfamily C member 9

multiple interactions

[rosiglitazone co-treated with Metformin] results in increased expression of ABCC9 mRNA alternative form; [rosiglitazone co-treated with Metformin] results in increased expression of ABCC9 protein alternative form

NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356

G

ATP binding cassette subfamily G member 5

decreases expression
increases expression

Metformin results in decreased expression of ABCG5 mRNA
Metformin results in increased expression of ABCG5 mRNA

PMID:27765674 PMID:31324951

NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563

G

ATP binding cassette subfamily G member 8

increases expression

Metformin results in increased expression of ABCG8 mRNA

NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912

G

abhydrolase domain containing 4, N-acyl phospholipase B

decreases expression

Metformin results in decreased expression of ABHD4 mRNA

NCBI chr15:27,697,384...27,716,013
Ensembl chr15:27,704,113...27,716,966

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of ABL1 mRNA

NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065

G

actin binding LIM protein family, member 3

increases expression

Metformin results in increased expression of ABLIM3 mRNA

NCBI chr18:55,256,135...55,376,629
Ensembl chr18:55,257,583...55,376,380

G

acetyl-CoA carboxylase alpha

decreases expression
multiple interactions
increases expression
increases phosphorylation
affects phosphorylation

Metformin results in decreased expression of ACACA mRNA; Metformin results in decreased expression of ACACA protein
Metformin inhibits the reaction [INS protein results in increased phosphorylation of ACACA protein]
Metformin results in increased expression of ACACA protein modified form
Metformin inhibits the reaction [Olanzapine results in decreased expression of ACACA mRNA]
Metformin results in increased expression of ACACA mRNA
Metformin results in increased phosphorylation of ACACA protein
Trientine inhibits the reaction [Metformin results in increased phosphorylation of ACACA protein]
Metformin analog affects the phosphorylation of ACACA protein

PMID:16760380 PMID:16873680 PMID:20956498 PMID:22492524 PMID:29991592 More...

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

G

acetyl-CoA carboxylase beta

increases phosphorylation

Metformin results in increased phosphorylation of ACACB protein

NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655

G

acetyl-CoA acetyltransferase 2

increases expression

Metformin results in increased expression of ACAT2 mRNA

NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821

G

angiotensin I converting enzyme

multiple interactions

Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of ACE mRNA]

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

angiotensin converting enzyme 2

increases expression
multiple interactions

Metformin results in increased expression of ACE2 mRNA
Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of ACE2 mRNA]

PMID:32808185 PMID:37120126

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

acetylcholinesterase

decreases activity
multiple interactions

Metformin results in decreased activity of ACHE protein
Metformin inhibits the reaction [[Fructose co-treated with Streptozocin] results in increased expression of ACHE protein]; Metformin inhibits the reaction [Chlorpyrifos results in decreased activity of ACHE protein]

PMID:28259689 PMID:33823243 PMID:35448458

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

ATP citrate lyase

multiple interactions
affects expression

[Metformin co-treated with caffeic acid] results in decreased expression of ACLY protein
Metformin affects the expression of ACLY mRNA

PMID:28576465 PMID:31324951

NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320

G

aminocarboxymuconate semialdehyde decarboxylase

decreases expression

Metformin results in decreased expression of ACMSD mRNA

NCBI chr13:39,200,412...39,245,954
Ensembl chr13:39,200,314...39,245,209

G

acyl-CoA thioesterase 2

increases expression

Metformin results in increased expression of ACOT2 mRNA

NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245

G

acyl-CoA thioesterase 3

increases expression

Metformin results in increased expression of ACOT3 mRNA

NCBI chr 6:103,682,518...103,688,735
Ensembl chr 6:103,682,596...103,688,427
Ensembl chr 6:103,682,596...103,688,427

G

acyl-CoA synthetase long-chain family member 1

decreases expression
multiple interactions

Metformin results in decreased expression of ACSL1 mRNA
Metformin inhibits the reaction [Oxygen deficiency results in increased expression of ACSL1 mRNA]

PMID:25596134 PMID:33476677

NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541

G

acyl-CoA synthetase medium-chain family member 3

increases expression

Metformin results in increased expression of ACSM3 mRNA

NCBI chr 1:174,133,260...174,159,966
Ensembl chr 1:174,133,288...174,160,184

G

actin, alpha 1, skeletal muscle

increases expression

Metformin results in increased expression of ACTA1 mRNA

NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742

G

actin alpha 2, smooth muscle

multiple interactions

Metformin inhibits the reaction [Dietary Fats results in increased expression of ACTA2 protein]; Metformin promotes the reaction [dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of ACTA2 protein]]

PMID:27551045 PMID:30551545

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

actinin, alpha 1

increases expression

Metformin results in increased expression of ACTN1 mRNA

NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251

G

adhesion G protein-coupled receptor E1

multiple interactions

Metformin inhibits the reaction [Folic Acid results in increased expression of ADGRE1 mRNA]

NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000

G

alcohol dehydrogenase 4 (class II), pi polypeptide

decreases expression

Metformin results in decreased expression of ADH4 mRNA

NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591

G

adiponectin, C1Q and collagen domain containing

decreases expression
multiple interactions
increases expression

Metformin results in decreased expression of ADIPOQ mRNA
Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of ADIPOQ protein]; Metformin inhibits the reaction [Olanzapine results in decreased expression of ADIPOQ protein]
Metformin results in increased expression of ADIPOQ protein
Metformin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein]; Metformin inhibits the reaction [Palmitic Acid results in decreased expression of ADIPOQ mRNA]
Cimetidine promotes the reaction [Metformin results in decreased expression of ADIPOQ mRNA]

PMID:20956498 PMID:25108154 PMID:30256492 PMID:32652086 PMID:37337224

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

adiponectin receptor 1

increases expression

Metformin results in increased expression of ADIPOR1 mRNA

NCBI chr13:45,859,461...45,879,248
Ensembl chr13:45,859,533...45,879,241

G

adiponectin receptor 2

increases expression

metformin increases expression of Adipor2 mRNA in liver

RGD

NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355

G

apoptosis enhancing nuclease

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of AEN mRNA]

NCBI chr 1:132,815,094...132,824,522
Ensembl chr 1:132,815,142...132,824,523

G

advanced glycosylation end product-specific receptor

multiple interactions

Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGER protein]; Metformin inhibits the reaction [Glucose promotes the reaction [Linoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]; Metformin inhibits the reaction [Linoleic Acid promotes the reaction [Glucose promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]

PMID:22467055 PMID:36999408

NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078

G

agrin

decreases expression

Metformin results in decreased expression of AGRN mRNA

NCBI chr 5:166,749,306...166,782,212
Ensembl chr 5:166,749,310...166,786,003

G

agouti related neuropeptide

multiple interactions

Metformin inhibits the reaction [Olanzapine results in increased expression of AGRP mRNA]

NCBI chr19:33,447,992...33,481,602
Ensembl chr19:33,447,992...33,449,584

G

angiotensinogen

multiple interactions

Metformin inhibits the reaction [AGT protein results in increased activity of and results in increased phosphorylation of HMGCR protein]; Metformin inhibits the reaction [AGT protein results in increased cleavage of and affects the localization of SREBF2 protein]; Metformin inhibits the reaction [AGT protein results in increased expression of LDLR protein]; Metformin inhibits the reaction [AGT protein results in increased expression of SREBF2 protein]; Metformin inhibits the reaction [AGT protein results in increased secretion of CCL2 protein]; Metformin inhibits the reaction [AGT protein results in increased secretion of TNF protein]

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 1a

multiple interactions

Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of AGTR1A mRNA]

NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946

G

aryl hydrocarbon receptor

decreases expression
affects activity
multiple interactions

Metformin results in decreased expression of AHR mRNA; Metformin results in decreased expression of AHR protein
Metformin affects the activity of AHR protein
Metformin inhibits the reaction [SP1 protein results in increased expression of AHR protein]; Metformin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of AHR protein]

PMID:25110054 PMID:25596134 PMID:25697376

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

apoptosis inducing factor, mitochondria associated 1

multiple interactions

Metformin inhibits the reaction [Acetaminophen affects the localization of AIFM1 protein]

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

AIF family member 2

decreases expression

Metformin results in decreased expression of AIFM2 mRNA

NCBI chr20:29,654,283...29,679,239
Ensembl chr20:29,652,927...29,679,236

G

adenylate kinase 3

decreases expression

Metformin results in decreased expression of AK3 mRNA

NCBI chr 1:226,737,472...226,764,647
Ensembl chr 1:226,739,318...226,764,625

G

adenylate kinase 4

decreases expression

Metformin results in decreased expression of AK4 mRNA

NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618

G

aldo-keto reductase family 1, member B8, pseudogene 2

decreases expression

Metformin results in decreased expression of AKR1B8-PS2 mRNA

NCBI chr 6:77,569,720...77,571,967

G

AKT serine/threonine kinase 1

multiple interactions
affects phosphorylation
increases phosphorylation
decreases phosphorylation

[Metformin co-treated with IGF1 protein] results in increased phosphorylation of AKT1 protein; [Metformin co-treated with IGF2 protein] results in increased phosphorylation of AKT1 protein; [Metformin co-treated with INS protein] results in increased phosphorylation of AKT1 protein; [Paclitaxel co-treated with Metformin] results in decreased expression of AKT1 mRNA; [Simvastatin co-treated with Metformin] results in decreased phosphorylation of AKT1 protein; AKT1 protein modified form inhibits the reaction [Metformin promotes the reaction [plantamajoside results in decreased phosphorylation of AKT1 protein]]; AKT1 protein modified form inhibits the reaction [Metformin promotes the reaction [plantamajoside results in decreased phosphorylation of GSK3B protein]]; AKT1 protein mutant form inhibits the reaction [[Metformin co-treated with NVP-BKM120] results in increased expression of BBC3 protein]; Metformin inhibits the reaction [Glucose results in increased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [INS protein results in decreased phosphorylation of AKT1 protein]; Metformin promotes the reaction [plantamajoside results in decreased phosphorylation of AKT1 protein]
Metformin affects the phosphorylation of AKT1 protein
Metformin results in increased phosphorylation of AKT1 protein
Metformin decreases phosphorylation of AKT1 protein in epithelial cell of alveolus of lung
Metformin inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [Olanzapine results in decreased expression of AKT1 mRNA]; Metformin inhibits the reaction [Streptozocin results in decreased phosphorylation of AKT1 protein]
Metformin inhibits the reaction [[Streptozocin co-treated with Coconut Oil co-treated with Cholesterol] results in decreased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [Methamphetamine results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [Streptozocin results in increased expression of AKT1 mRNA]; Metformin inhibits the reaction [Testosterone results in increased phosphorylation of AKT1 protein]

CTD
RGD

PMID:16385087 PMID:21664031 PMID:25412314 PMID:26492952 PMID:26835874 More...

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

AKT serine/threonine kinase 2

multiple interactions

Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of AKT2 protein]

NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817

G

AKT serine/threonine kinase 3

decreases expression

Metformin results in decreased expression of AKT3 mRNA

NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708

G

5'-aminolevulinate synthase 2

decreases expression

Metformin results in decreased expression of ALAS2 mRNA

NCBI chr X:19,463,146...19,486,526
Ensembl chr X:19,463,171...19,486,519

G

albumin

multiple interactions

Metformin inhibits the reaction [Streptozocin results in increased expression of ALB protein]

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 18 family, member A1

increases expression

Metformin results in increased expression of ALDH18A1 mRNA

NCBI chr 1:239,375,657...239,407,956
Ensembl chr 1:239,375,669...239,407,890

G

aldehyde dehydrogenase 1 family, member A1

increases expression

Metformin results in increased expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldolase, fructose-bisphosphate A

increases expression

Metformin results in increased expression of ALDOA mRNA

NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182

G

arachidonate 15-lipoxygenase

decreases expression

Metformin results in decreased expression of ALOX15 mRNA

NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874

G

alkaline phosphatase, biomineralization associated

multiple interactions

Metformin inhibits the reaction [BMP2 protein results in increased expression of ALPL mRNA]

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

alpha-1-microglobulin/bikunin precursor

decreases expression

Metformin results in decreased expression of AMBP mRNA

NCBI chr 5:76,568,094...76,578,416
Ensembl chr 5:76,568,094...76,578,331

G

angiopoietin 1

decreases expression

Metformin results in decreased expression of ANGPT1 mRNA

NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067

G

angiopoietin-like 4

decreases expression
increases expression

Metformin results in decreased expression of ANGPTL4 mRNA
Metformin results in increased expression of ANGPTL4 mRNA

PMID:25596134 PMID:31324951

NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519

G

angiopoietin-like 8

increases expression

Metformin results in increased expression of ANGPTL8 mRNA

NCBI chr 8:20,376,462...20,378,488
Ensembl chr 8:20,376,462...20,378,490

G

apoptotic peptidase activating factor 1

multiple interactions

[Paclitaxel co-treated with Metformin] results in increased expression of APAF1 mRNA

NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540

G

apurinic/apyrimidinic endodeoxyribonuclease 1

multiple interactions

Metformin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of APEX1 mRNA]

NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785

G

apolipoprotein A5

decreases expression

Metformin results in decreased expression of APOA5 mRNA

NCBI chr 8:46,561,180...46,563,818
Ensembl chr 8:46,561,229...46,563,816

G

apolipoprotein F

decreases expression

Metformin results in decreased expression of APOF mRNA

NCBI chr 7:700,688...702,130
Ensembl chr 7:700,762...701,946

G

adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1

multiple interactions
increases expression

Metformin promotes the reaction [APPL1 protein binds to RAB5A protein]
Metformin results in increased expression of APPL1 protein

NCBI chr16:2,118,503...2,166,741
Ensembl chr16:2,121,255...2,166,692

G

aquaporin 7

increases expression

Metformin results in increased expression of AQP7 mRNA

NCBI chr 5:56,171,649...56,186,642
Ensembl chr 5:56,172,519...56,186,642

G

ADP-ribosylation factor GTPase activating protein 3

increases expression

Metformin results in increased expression of ARFGAP3 mRNA

NCBI chr 7:114,432,873...114,479,206
Ensembl chr 7:114,432,873...114,479,208

G

ADP ribosylation factor guanine nucleotide exchange factor 2

increases expression

Metformin results in increased expression of ARFGEF2 mRNA

NCBI chr 3:155,547,504...155,633,652
Ensembl chr 3:155,547,538...155,630,856

G

arginase 1

multiple interactions

Metformin inhibits the reaction [Palmitic Acid results in decreased expression of ARG1 mRNA]
Metformin inhibits the reaction [IL13 protein results in increased expression of ARG1 mRNA]

PMID:25108154 PMID:26497364

NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422

G

Rho guanine nucleotide exchange factor 10

decreases expression

Metformin results in decreased expression of ARHGEF10 mRNA

NCBI chr16:74,647,147...74,738,784
Ensembl chr16:74,647,153...74,738,173

G

ADP-ribosylation factor like GTPase 1

decreases expression

Metformin results in decreased expression of ARL1 mRNA

NCBI chr 7:23,120,004...23,131,173
Ensembl chr 7:23,119,589...23,131,898

G

actin related protein 2/3 complex, subunit 5-like

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of ARPC5L mRNA]

NCBI chr 3:22,758,710...22,767,520
Ensembl chr 3:22,759,876...22,767,538
Ensembl chr 9:22,759,876...22,767,538

G

arrestin domain containing 3

decreases expression

Metformin results in decreased expression of ARRDC3 mRNA

NCBI chr 2:11,137,464...11,149,978
Ensembl chr 2:11,137,460...11,149,978

G

argininosuccinate lyase

decreases expression

Metformin results in decreased expression of ASL mRNA

NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

Metformin results in increased expression of ASNS mRNA

PMID:25596134 PMID:31324951

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

activating transcription factor 3

increases expression

Metformin results in increased expression of ATF3 mRNA

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

activating transcription factor 4

affects activity
multiple interactions

Metformin affects the activity of ATF4 protein
Metformin inhibits the reaction [Rotenone results in increased expression of ATF4 mRNA]

PMID:25596134 PMID:32189544

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

activating transcription factor 5

increases expression

Metformin results in increased expression of ATF5 mRNA

NCBI chr 1:95,295,602...95,299,755
Ensembl chr 1:95,295,610...95,299,707

G

activating transcription factor 6

multiple interactions

Metformin inhibits the reaction [Rotenone results in increased expression of ATF6 mRNA]
Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of ATF6 protein]; Metformin inhibits the reaction [Glucose results in increased expression of and affects the localization of ATF6 protein]

PMID:32189544 PMID:34801538

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

autophagy related 5

multiple interactions

Metformin inhibits the reaction [Blood Glucose results in increased expression of ATG5 protein]

NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209

G

ATM serine/threonine kinase

affects response to substance
increases expression

ATM gene SNP affects the susceptibility to Metformin
Metformin increases expression of ATM protein in epithelial cell of alveolus of lung

CTD
RGD

PMID:21186350 PMID:23632475

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

atos homolog A

decreases expression

Metformin results in decreased expression of ATOSA mRNA

NCBI chr 8:75,694,828...75,772,565
Ensembl chr 8:75,695,022...75,772,549

G

ATPase Na+/K+ transporting subunit alpha 2

decreases expression

Metformin results in decreased expression of ATP1A2 mRNA

NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544

G

ATPase Na+/K+ transporting subunit alpha 3

increases expression

Metformin results in increased expression of ATP1A3 mRNA

NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

multiple interactions

Metformin inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary] results in decreased expression of ATP2A2 protein]

NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101

G

ATP synthase membrane subunit c locus 2

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of ATP5MC2 mRNA]

NCBI chr 7:133,791,341...133,799,713
Ensembl chr 7:133,791,342...133,799,733

G

ATPase H+ transporting V0 subunit D2

decreases expression

Metformin results in decreased expression of ATP6V0D2 mRNA

NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354

G

ATR serine/threonine kinase

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of ATR mRNA

NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136

G

aurora kinase B

increases expression

Metformin results in increased expression of AURKB mRNA

NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837

G

apoptosis and caspase activation inhibitor

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of AVEN mRNA

NCBI chr 3:99,299,009...99,431,635
Ensembl chr 3:99,298,930...99,431,634

G

beta-2 microglobulin

multiple interactions

Metformin inhibits the reaction [Streptozocin results in increased expression of B2M protein]

PMID:33639173 PMID:34649470

NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766

G

BCL2-associated agonist of cell death

increases expression
multiple interactions

Metformin results in increased expression of BAD protein
Cisplatin promotes the reaction [Metformin results in increased expression of BAD protein]; Metformin inhibits the reaction [INS protein results in decreased expression of BAD protein]

PMID:21388661 PMID:33651899

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BAG cochaperone 1

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of BAG1 mRNA

NCBI chr 5:56,068,494...56,081,075
Ensembl chr 5:56,068,494...56,081,075

G

BCL2 associated X, apoptosis regulator

multiple interactions
affects expression
increases expression

Cisplatin promotes the reaction [Metformin results in increased expression of BAX protein]
Metformin inhibits the reaction [Streptozocin results in increased expression of BAX protein]; SIRT3 protein promotes the reaction [Metformin inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]]; SIRT3 protein promotes the reaction [Metformin inhibits the reaction [Cisplatin results in increased expression of BAX protein]]
Metformin affects the expression of BAX protein
Metformin inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]; Metformin inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Metformin inhibits the reaction [Glucose results in increased expression of BAX protein]; Metformin inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]; Metformin inhibits the reaction [Testosterone results in decreased expression of BAX mRNA]
Metformin results in increased expression of BAX mRNA

PMID:21388661 PMID:25596134 PMID:26492952 PMID:28106847 PMID:29226720 More...

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

Bcl-2 binding component 3

multiple interactions

[Metformin co-treated with NVP-BKM120] results in increased expression of BBC3 mRNA; [Metformin co-treated with NVP-BKM120] results in increased expression of BBC3 protein; AKT1 protein mutant form inhibits the reaction [[Metformin co-treated with NVP-BKM120] results in increased expression of BBC3 protein]; BBC3 protein promotes the reaction [[Metformin co-treated with NVP-BKM120] results in increased cleavage of CASP3 protein]; FOXO3 protein promotes the reaction [[Metformin co-treated with NVP-BKM120] results in increased expression of BBC3 protein]

NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509

G

BCAR3 adaptor protein, NSP family member

affects expression

Metformin affects the expression of BCAR3 mRNA

NCBI chr 2:210,525,260...210,638,674
Ensembl chr 2:210,525,260...210,638,798

G

branched chain amino acid transaminase 2

decreases expression

Metformin results in decreased expression of BCAT2 mRNA

PMID:25596134 PMID:31324951

NCBI chr 1:96,040,407...96,060,008
Ensembl chr 1:96,042,625...96,060,007

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

Metformin results in decreased expression of BCL2 protein
Metformin inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein]
Metformin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Metformin inhibits the reaction [Glucose results in decreased expression of BCL2 protein]; Metformin inhibits the reaction [Streptozocin results in increased expression of BCL2 mRNA]; Metformin inhibits the reaction [Testosterone results in increased expression of BCL2 mRNA]
[Paclitaxel co-treated with Metformin] results in decreased expression of BCL2 mRNA; Cisplatin promotes the reaction [Metformin results in decreased expression of BCL2 protein]

PMID:21388661 PMID:26492952 PMID:26818447 PMID:28106847 PMID:29226720 More...

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions
decreases expression

Cisplatin promotes the reaction [Metformin results in decreased expression of BCL2L1 protein]
Metformin inhibits the reaction [Streptozocin results in increased expression of BCL2L1 mRNA]

PMID:21388661 PMID:35414346

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

BCL6, transcription repressor

increases expression

Metformin results in increased expression of BCL6 mRNA

NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389

G

brain-derived neurotrophic factor

multiple interactions

Metformin inhibits the reaction [Methamphetamine results in decreased expression of BDNF protein]; Metformin inhibits the reaction [Streptozocin results in increased expression of BDNF mRNA]

PMID:30742852 PMID:35414346

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

beclin 1

increases expression
multiple interactions

Metformin results in increased expression of BECN1 protein
Metformin inhibits the reaction [Blood Glucose results in increased expression of BECN1 protein]; Metformin inhibits the reaction [Blood Glucose results in increased phosphorylation of BECN1 protein]
plantamajoside promotes the reaction [Metformin results in increased expression of BECN1 protein]

PMID:33021114 PMID:35350904

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

basic helix-loop-helix family, member e40

affects expression

Metformin affects the expression of BHLHE40 mRNA

NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774

G

baculoviral IAP repeat-containing 5

decreases expression

Metformin results in decreased expression of BIRC5 protein

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

basic helix-loop-helix ARNT like 1

decreases expression

Metformin results in decreased expression of BMAL1 mRNA

NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231

G

Bcl2 modifying factor

decreases expression

Metformin results in decreased expression of BMF mRNA

NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145

G

bone morphogenetic protein 2

multiple interactions

Metformin inhibits the reaction [BMP2 protein results in decreased expression of CDH1 mRNA]; Metformin inhibits the reaction [BMP2 protein results in increased expression of ALPL mRNA]; Metformin inhibits the reaction [BMP2 protein results in increased expression of BMP4 mRNA]; Metformin inhibits the reaction [BMP2 protein results in increased expression of RUNX2 mRNA]; Metformin inhibits the reaction [BMP2 protein results in increased expression of RUNX2 protein]; Metformin inhibits the reaction [BMP2 protein results in increased expression of SP7 mRNA]; Metformin inhibits the reaction [BMP2 protein results in increased expression of SP7 protein]; Metformin inhibits the reaction [BMP2 protein results in increased expression of VIM mRNA]

NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397

G

bone morphogenetic protein 4

multiple interactions

Metformin inhibits the reaction [BMP2 protein results in increased expression of BMP4 mRNA]

NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306

G

BCL2 interacting protein 3

increases expression

Metformin results in increased expression of BNIP3 mRNA

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

G

bisphosphoglycerate mutase

decreases expression

Metformin results in decreased expression of BPGM mRNA

NCBI chr 4:63,139,730...63,168,581
Ensembl chr 4:63,140,018...63,168,581

G

bromodomain containing 2

affects expression

Metformin affects the expression of BRD2 mRNA

NCBI chr20:4,727,078...4,735,389
Ensembl chr20:4,728,151...4,735,388

G

BTG anti-proliferation factor 2

affects expression
decreases expression

Metformin affects the expression of BTG2 mRNA
Metformin results in decreased expression of BTG2 mRNA

PMID:25596134 PMID:31324951

NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628

G

BUB1 mitotic checkpoint serine/threonine kinase B

affects expression

Metformin affects the expression of BUB1B mRNA

NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547

G

calcium voltage-gated channel subunit alpha1 D

decreases expression

Metformin results in decreased expression of CACNA1D mRNA

NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215

G

calnexin

multiple interactions

Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of CANX protein]

NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821

G

cysteinyl-tRNA synthetase 1

increases expression

Metformin results in increased expression of CARS1 mRNA

PMID:25596134 PMID:31324951

NCBI chr 1:198,753,689...198,796,016
Ensembl chr 1:198,753,691...198,795,941

G

caspase 1

multiple interactions

[Paclitaxel co-treated with Metformin] results in increased expression of CASP1 mRNA
Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased cleavage of CASP1 protein]

PMID:29309887 PMID:36999408

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 14

multiple interactions

[Paclitaxel co-treated with Metformin] results in increased expression of CASP14 mRNA

NCBI chr 7:10,929,759...10,932,591
Ensembl chr 7:10,926,725...10,933,405

G

caspase 3

multiple interactions
increases cleavage
increases expression
decreases activity
increases activity

[epothilone A co-treated with Metformin] results in increased expression of CASP3 mRNA; [Metformin co-treated with NVP-BKM120] results in increased cleavage of CASP3 protein; BBC3 protein promotes the reaction [[Metformin co-treated with NVP-BKM120] results in increased cleavage of CASP3 protein]; Cisplatin promotes the reaction [Metformin results in increased activity of CASP3 protein]; FOXO3 protein promotes the reaction [[Metformin co-treated with NVP-BKM120] results in increased cleavage of CASP3 protein]; Metformin inhibits the reaction [Sunitinib results in increased cleavage of CASP3 protein]; plantamajoside promotes the reaction [Metformin results in increased cleavage of CASP3 protein]; Sodium Salicylate promotes the reaction [[epothilone A co-treated with Metformin] results in increased expression of CASP3 mRNA]; Sodium Salicylate promotes the reaction [Metformin results in increased expression of CASP3 mRNA]; triciribine promotes the reaction [[epothilone A co-treated with Metformin] results in increased expression of CASP3 mRNA]
Deoxyglucose promotes the reaction [Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein modified form]]; Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein modified form]; Metformin inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; SIRT3 protein promotes the reaction [Metformin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]]
Metformin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 mRNA]; Metformin inhibits the reaction [Dietary Fats results in increased expression of and results in increased cleavage of CASP3 protein]; Metformin inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]; Metformin inhibits the reaction [Glucose results in increased activity of CASP3 protein]; Metformin inhibits the reaction [Glucose results in increased expression of and results in increased activity of CASP3 protein]; Metformin inhibits the reaction [Streptozocin results in increased expression of CASP3 mRNA]
Metformin results in decreased activity of CASP3 protein

PMID:15531508 PMID:21388661 PMID:21906609 PMID:26818447 PMID:27551045 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 4

multiple interactions

[Paclitaxel co-treated with Metformin] results in increased expression of CASP4 mRNA

NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092

G

caspase 7

multiple interactions
increases activity

Cisplatin promotes the reaction [Metformin results in increased activity of CASP7 protein]; Metformin inhibits the reaction [Sunitinib results in increased cleavage of CASP7 protein]
dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]; Metformin promotes the reaction [dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]]

PMID:21388661 PMID:21906609 PMID:30551545

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

decreases activity
multiple interactions

Metformin results in decreased activity of CASP8 protein
[Paclitaxel co-treated with Metformin] results in increased expression of CASP8 mRNA

PMID:15531508 PMID:29309887

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

calsequestrin 1

decreases expression

Metformin results in decreased expression of CASQ1 mRNA

NCBI chr13:84,670,648...84,680,339
Ensembl chr13:84,670,649...84,680,339

G

catalase

multiple interactions
decreases activity
increases activity
decreases expression
increases expression

Metformin inhibits the reaction [[Fructose co-treated with Streptozocin] results in decreased activity of CAT protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of CAT protein]; Metformin inhibits the reaction [Doxorubicin results in decreased expression of CAT mRNA]; Metformin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; Metformin inhibits the reaction [Streptozocin results in decreased expression of CAT mRNA]
Metformin results in decreased activity of CAT protein
Metformin results in increased activity of CAT protein
Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of CAT protein]; Metformin promotes the reaction [Carbon Tetrachloride results in increased activity of CAT protein]
Metformin results in decreased expression of CAT mRNA
Metformin results in increased expression of CAT mRNA

PMID:15531508 PMID:21457706 PMID:22627169 PMID:22666520 PMID:24717679 More...

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

chibby 1, beta catenin antagonist

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CBY1 mRNA]

NCBI chr 7:111,216,835...111,223,305

G

coiled-coil domain containing 38

increases expression

Metformin results in increased expression of CCDC38 mRNA

NCBI chr 7:28,055,883...28,129,938
Ensembl chr 7:28,059,798...28,130,441

G

coiled-coil domain containing 77

increases expression

Metformin results in increased expression of CCDC77 mRNA

NCBI chr 4:153,534,184...153,566,059
Ensembl chr 4:153,534,187...153,566,545

G

coiled-coil domain containing 90B

increases expression

Metformin results in increased expression of CCDC90B mRNA

NCBI chr 1:146,632,756...146,646,314
Ensembl chr 1:146,633,036...146,647,338

G

C-C motif chemokine ligand 2

decreases expression
multiple interactions

Metformin results in decreased expression of CCL2 mRNA
Metformin inhibits the reaction [AGT protein results in increased secretion of CCL2 protein]; Metformin inhibits the reaction [Folic Acid results in increased expression of CCL2 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of CCL2 mRNA]
Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of CCL2 protein]; Metformin inhibits the reaction [Palmitic Acid results in increased expression of CCL2 mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]

PMID:20956498 PMID:25108154 PMID:26497364 PMID:29380373 PMID:29499335 More...

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 24

multiple interactions

Metformin inhibits the reaction [IL13 protein results in increased expression of CCL24 mRNA]

NCBI chr12:21,100,835...21,104,832
Ensembl chr12:21,100,835...21,104,893

G

C-C motif chemokine ligand 27

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of CCL27A mRNA]

NCBI chr 5:56,941,402...56,948,511
Ensembl chr 5:56,941,402...56,948,506

G

C-C motif chemokine ligand 7

multiple interactions

Metformin inhibits the reaction [IL13 protein results in increased expression of CCL7 mRNA]

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

G

cellular communication network factor 2

decreases expression

Metformin results in decreased expression of CCN2 mRNA

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

cyclin B1

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of CCNB1 mRNA

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin B2

multiple interactions
increases expression

[Paclitaxel co-treated with Metformin] results in decreased expression of CCNB2 mRNA
Metformin results in increased expression of CCNB2 mRNA

PMID:29309887 PMID:31324951

NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874

G

cyclin C

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of CCNC mRNA

NCBI chr 5:35,266,828...35,284,943
Ensembl chr 5:35,266,823...35,296,584

G

cyclin D1

multiple interactions
decreases expression

[Paclitaxel co-treated with Metformin] results in decreased expression of CCND1 mRNA
Metformin results in decreased expression of CCND1 protein

PMID:29226720 PMID:29309887

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D2

multiple interactions
decreases expression

Metformin inhibits the reaction [FSHB protein results in increased expression of CCND2 protein]
[Paclitaxel co-treated with Metformin] results in decreased expression of CCND2 mRNA
Metformin results in decreased expression of CCND2 protein

PMID:16760380 PMID:29309887

NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495

G

cyclin E1

multiple interactions
decreases expression

Metformin inhibits the reaction [FSHB protein results in increased expression of CCNE1 protein]
[Metformin co-treated with NVP-BKM120] results in decreased expression of CCNE1 protein; [Paclitaxel co-treated with Metformin] results in decreased expression of CCNE1 mRNA
Metformin results in decreased expression of CCNE1 protein

PMID:16760380 PMID:29309887 PMID:38479708

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cyclin F

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of CCNF mRNA

NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101

G

cyclin G1

increases expression
multiple interactions

Metformin results in increased expression of CCNG1 mRNA
[Paclitaxel co-treated with Metformin] results in decreased expression of CCNG1 mRNA

PMID:19022234 PMID:29309887

NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641

G

cyclin G2

decreases expression
multiple interactions

Metformin results in decreased expression of CCNG2 mRNA
[Paclitaxel co-treated with Metformin] results in decreased expression of CCNG2 mRNA

PMID:25596134 PMID:29309887

NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830

G

C-C motif chemokine receptor 2

multiple interactions

Metformin inhibits the reaction [IL13 protein results in increased expression of CCR2 mRNA]

NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100

G

CD14 molecule

increases expression

Metformin results in increased expression of CD14 protein

NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261

G

CD40 ligand

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of CD40LG mRNA

NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306

G

CD52 molecule

decreases expression

Metformin results in decreased expression of CD52 mRNA

NCBI chr 5:146,319,789...146,321,348
Ensembl chr 5:146,319,969...146,321,348

G

Cd63 molecule

increases expression

Metformin results in increased expression of CD63 mRNA

NCBI chr 7:1,325,108...1,340,447
Ensembl chr 7:1,325,103...1,399,178

G

CD74 molecule

decreases expression

Metformin results in decreased expression of CD74 mRNA

NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003

G

cell division cycle 16

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of CDC16 mRNA

NCBI chr16:75,773,026...75,796,586
Ensembl chr16:75,773,028...75,796,550

G

cell division cycle 20

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of CDC20 mRNA

NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512

G

cell division cycle 25A

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of CDC25A mRNA

NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701

G

cell division cycle 25B

decreases expression

Metformin results in decreased expression of CDC25B mRNA

NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272

G

cell division cycle 34, ubiqiutin conjugating enzyme

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of CDC34 mRNA

NCBI chr 7:10,017,588...10,023,586
Ensembl chr 7:10,017,588...10,023,186

G

cell division cycle 42

decreases expression

Metformin results in decreased expression of CDC42 mRNA

NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111

G

cadherin 1

multiple interactions

[Metformin co-treated with NVP-BKM120] results in increased expression of CDH1 protein; Metformin inhibits the reaction [BMP2 protein results in decreased expression of CDH1 mRNA]

PMID:37409753 PMID:38479708

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cell death-inducing p53 target 1

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CDIP1 mRNA]

NCBI chr10:10,773,538...10,796,979
Ensembl chr10:10,774,705...10,796,980

G

cyclin-dependent kinase 1

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of CDK1 mRNA

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin dependent kinase 2

multiple interactions

[Metformin co-treated with NVP-BKM120] results in decreased expression of CDK2 protein; [Paclitaxel co-treated with Metformin] results in decreased expression of CDK2 mRNA

PMID:29309887 PMID:38479708

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 4

multiple interactions
increases expression

[Paclitaxel co-treated with Metformin] results in decreased expression of CDK4 mRNA
Metformin results in increased expression of CDK4 protein

PMID:29226720 PMID:29309887

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase 5 regulatory subunit 1

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of CDK5R1 mRNA

NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456

G

cyclin-dependent kinase 6

increases expression

Metformin results in increased expression of CDK6 mRNA

NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634

G

cyclin-dependent kinase 7

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of CDK7 mRNA

NCBI chr 2:31,840,558...31,865,422
Ensembl chr 2:31,840,558...31,865,383

G

cyclin-dependent kinase 8

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of CDK8 mRNA

NCBI chr12:8,737,198...8,805,026
Ensembl chr12:8,737,262...8,804,177

G

cyclin-dependent kinase inhibitor 1A

increases expression
multiple interactions

Metformin results in increased expression of CDKN1A mRNA
[Metformin co-treated with NVP-BKM120] results in increased expression of CDKN1A protein
Metformin inhibits the reaction [Testosterone results in decreased expression of CDKN1A mRNA]

PMID:25596134 PMID:26492952 PMID:31324951 PMID:38479708

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

multiple interactions

[Paclitaxel co-treated with Metformin] results in increased expression of CDKN1B mRNA

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

CCAAT/enhancer binding protein alpha

decreases expression

Metformin results in decreased expression of CEBPA mRNA

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

G

ceramide synthase 5

increases expression

Metformin results in increased expression of CERS5 mRNA

NCBI chr 7:130,859,993...130,897,979
Ensembl chr 7:130,859,990...130,897,947

G

complement factor D

decreases expression

Metformin results in decreased expression of CFD mRNA

NCBI chr 7:9,813,148...9,814,871
Ensembl chr 7:9,813,150...9,815,053

G

checkpoint kinase 1

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of CHEK1 mRNA

NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009

G

checkpoint kinase 2

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of CHEK2 mRNA

NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286

G

component of inhibitor of nuclear factor kappa B kinase complex

decreases expression
multiple interactions

Metformin results in decreased expression of CHUK mRNA
[Metformin co-treated with Pioglitazone] results in decreased expression of CHUK mRNA

NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065

G

cytokine inducible SH2-containing protein

decreases expression

Metformin results in decreased expression of CISH mRNA

NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250

G

cytoskeleton associated protein 2

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CKAP2 mRNA]

NCBI chr16:69,839,668...69,864,852
Ensembl chr16:69,839,630...69,864,913

G

claudin 2

decreases expression

Metformin results in decreased expression of CLDN2 protein

NCBI chr X:103,459,870...103,473,794
Ensembl chr X:103,459,780...103,474,838

G

claudin 3

decreases expression

Metformin results in decreased expression of CLDN3 mRNA

NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001

G

carboxymethylenebutenolidase homolog

decreases expression

Metformin results in decreased expression of CMBL mRNA

NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:82,571,888...82,591,009

G

cyclin Pas1/PHO80 domain containing 1

decreases expression

Metformin results in decreased expression of CNPPD1 mRNA

NCBI chr 9:76,633,475...76,640,164
Ensembl chr 9:76,633,477...76,640,188

G

collagen type IV alpha 1 chain

multiple interactions

Metformin inhibits the reaction [Folic Acid results in increased expression of COL4A1 mRNA]

NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412

G

carnitine palmitoyltransferase 1A

decreases expression
affects expression

Metformin results in decreased expression of CPT1A mRNA
Metformin affects the expression of CPT1A mRNA

PMID:19022234 PMID:31324951

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

ceramide-1-phosphate transfer protein

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CPTP mRNA]

NCBI chr 5:166,474,947...166,479,103
Ensembl chr 5:166,474,966...166,479,017

G

cAMP responsive element binding protein 1

multiple interactions

Metformin inhibits the reaction [Methamphetamine results in decreased expression of and results in decreased phosphorylation of CREB1 protein]

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

cAMP responsive element binding protein 3-like 2

multiple interactions
increases expression

Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CREB3L2 mRNA]
Metformin results in increased expression of CREB3L2 mRNA

PMID:29095437 PMID:31324951

NCBI chr 4:65,907,570...66,112,078
Ensembl chr 4:65,907,655...66,023,763

G

CREB3 regulatory factor

decreases expression

Metformin results in decreased expression of CREBRF mRNA

NCBI chr10:16,399,170...16,479,650
Ensembl chr10:16,404,596...16,461,999

G

cysteine-rich with EGF-like domains 2

increases expression

Metformin results in increased expression of CRELD2 mRNA

NCBI chr 7:119,909,626...119,916,556
Ensembl chr 7:119,909,633...119,916,543

G

carnitine O-octanoyltransferase

increases expression

Metformin results in increased expression of CROT mRNA

NCBI chr 4:25,068,270...25,133,111
Ensembl chr 4:25,080,587...25,133,109

G

C-reactive protein

decreases expression
multiple interactions

Metformin results in decreased expression of CRP protein
Metformin inhibits the reaction [Fructose results in increased expression of CRP protein]

PMID:14557435 PMID:25108154

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

cystatin C

multiple interactions

Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CST3 protein]

NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822

G

CTD phosphatase subunit 1

increases expression

Metformin results in increased expression of CTDP1 mRNA

NCBI chr18:73,854,277...73,916,232
Ensembl chr18:73,854,282...73,916,457

G

CTD small phosphatase 2

decreases expression

Metformin results in decreased expression of CTDSP2 mRNA

NCBI chr 7:62,805,398...62,825,306
Ensembl chr 7:62,805,658...62,825,302

G

cystathionine gamma-lyase

decreases expression

Metformin results in decreased expression of CTH mRNA

NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234

G

catenin beta 1

decreases expression

Metformin results in decreased expression of CTNNB1 protein

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cathepsin C

decreases expression

Metformin results in decreased expression of CTSC mRNA

NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387

G

cortactin

increases expression

Metformin results in increased expression of CTTN mRNA

NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164

G

CTTNBP2 N-terminal like

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of CTTNBP2NL mRNA]

NCBI chr 2:192,507,963...192,554,548
Ensembl chr 2:192,507,963...192,541,101

G

C-X-C motif chemokine ligand 1

affects expression
multiple interactions

Metformin affects the expression of CXCL1 mRNA
Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin] inhibits the reaction [Ovalbumin results in increased expression of CXCL1 protein]]

PMID:31324951 PMID:36547818

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 13

decreases expression

Metformin results in decreased expression of CXCL13 mRNA

NCBI chr14:13,608,894...13,613,965
Ensembl chr14:13,608,902...13,613,933

G

C-X-C motif chemokine ligand 2

multiple interactions

Metformin inhibits the reaction [IL13 protein results in increased expression of CXCL2 mRNA]

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine ligand 9

decreases expression

Metformin results in decreased expression of CXCL9 mRNA

NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435

G

cytochrome b-245 alpha chain

decreases expression
multiple interactions

Metformin results in decreased expression of CYBA mRNA
Metformin affects the reaction [Dehydroepiandrosterone results in increased expression of CYBA protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of CYBA mRNA]

PMID:15531508 PMID:27634381

NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721

G

cytochrome b-245 beta chain

multiple interactions

Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of CYBB protein]
Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of NOX2 mRNA]

PMID:35085591 PMID:37120126

NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586

G

cytochrome c, somatic

multiple interactions

Metformin inhibits the reaction [Streptozocin results in increased expression of CYCS mRNA]
Metformin inhibits the reaction [Doxorubicin results in increased secretion of CYCS protein]; Metformin inhibits the reaction [Streptozocin affects the localization of CYCS protein]

PMID:34649470 PMID:35414346 PMID:37453608

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 11, subfamily a, polypeptide 1

multiple interactions

Metformin inhibits the reaction [FSHB protein results in increased expression of CYP11A1 protein]

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases expression
multiple interactions
affects expression

Metformin results in decreased expression of CYP17A1 mRNA
Metformin inhibits the reaction [Letrozole results in increased expression of CYP17A1 mRNA]
Metformin affects the expression of CYP17A1 mRNA

PMID:23166782 PMID:31324951 PMID:32298659

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions

Metformin inhibits the reaction [FSHB protein results in increased expression of CYP19A1 protein]

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
decreases expression
increases expression

Metformin promotes the reaction [Streptozocin results in increased expression of CYP1A1 mRNA]
Metformin results in decreased expression of CYP1A1 mRNA
Metformin results in decreased expression of CYP1A1 mRNA; Metformin results in decreased expression of CYP1A1 protein
Metformin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of and results in increased activity of CYP1A1 protein]; Metformin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 mRNA]; Metformin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
Metformin results in increased expression of CYP1A1 mRNA

PMID:22342832 PMID:25110054 PMID:25596134 PMID:25697376

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases expression
decreases expression

Metformin results in increased expression of CYP1A2 mRNA
Metformin results in decreased expression of CYP1A2 mRNA

PMID:19022234 PMID:25596134

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions
decreases expression

Metformin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 protein]
Metformin results in decreased expression of CYP1B1 mRNA; Metformin results in decreased expression of CYP1B1 protein

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 27, subfamily a, polypeptide 1

decreases expression
multiple interactions

Metformin results in decreased expression of CYP27A1 mRNA
[Ethinyl Estradiol co-treated with Metformin] results in decreased expression of CYP27A1 mRNA; [Metformin co-treated with Ethinyl Estradiol] results in decreased expression of CYP27A1 protein

NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551

G

cytochrome P450, family 27, subfamily b, polypeptide 1

multiple interactions

[Paclitaxel co-treated with Metformin] results in increased expression of CYP27B1 mRNA

NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases expression

Metformin results in increased expression of CYP2B10 mRNA

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily c, polypeptide 12

increases expression

Metformin results in increased expression of CYP2C12 mRNA

NCBI chr 1:238,699,859...238,757,011
Ensembl chr 1:238,699,854...238,757,019

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases expression

Metformin results in increased expression of CYP2E1 mRNA

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression
decreases expression
multiple interactions

Metformin results in increased expression of CYP3A4 mRNA
Metformin results in decreased expression of CYP3A4 mRNA
Metformin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; Metformin inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein]

PMID:19022234 PMID:21920351

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450 family 7 subfamily A member 1

multiple interactions
increases expression
affects expression

Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP7A1 mRNA]; Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP7A1 protein]
Metformin results in increased expression of CYP7A1 protein
[Ethinyl Estradiol co-treated with Metformin] results in decreased expression of CYP7A1 mRNA; [Metformin co-treated with Ethinyl Estradiol] results in decreased expression of CYP7A1 protein
Metformin affects the expression of CYP7A1 mRNA

PMID:31100278 PMID:31324951 PMID:34058177

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

cytochrome P450 family 7 subfamily B member 1

multiple interactions

[Ethinyl Estradiol co-treated with Metformin] results in decreased expression of CYP7B1 mRNA

NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698

G

cytochrome P450 family 8 subfamily B member 1

increases expression
decreases expression
multiple interactions

Metformin results in increased expression of CYP8B1 mRNA
Metformin results in decreased expression of CYP8B1 protein
[Ethinyl Estradiol co-treated with Metformin] results in decreased expression of CYP8B1 mRNA; [Metformin co-treated with Ethinyl Estradiol] results in decreased expression of CYP8B1 protein

PMID:31324951 PMID:34058177

NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166

G

death associated protein kinase 1

multiple interactions

[Paclitaxel co-treated with Metformin] results in increased expression of DAPK1 mRNA

NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991

G

dicarbonyl and L-xylulose reductase

decreases expression

Metformin results in decreased expression of DCXR mRNA

NCBI chr10:106,006,404...106,008,293

G

DDHD domain containing 1

increases expression

Metformin results in increased expression of DDHD1 mRNA

NCBI chr15:18,824,389...18,891,036
Ensembl chr15:18,824,394...18,890,952

G

DNA damage inducible 1 homolog 2

decreases expression

Metformin results in decreased expression of DDI2 mRNA

NCBI chr 5:153,989,591...154,035,342
Ensembl chr 5:153,995,589...154,035,283

G

DNA-damage inducible transcript 3

increases expression
multiple interactions

Metformin results in increased expression of DDIT3 mRNA
Metformin inhibits the reaction [INS protein results in increased expression of DDIT3 protein]
Metformin inhibits the reaction [Glucose results in increased expression of DDIT3 protein]
Metformin inhibits the reaction [Rotenone results in increased expression of DDIT3 mRNA]

PMID:25596134 PMID:32189544 PMID:34801538 PMID:36764371

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DNA-damage-inducible transcript 4

decreases expression
multiple interactions
increases expression

Metformin results in decreased expression of DDIT4 mRNA
[Metformin co-treated with Pioglitazone] results in increased expression of DDIT4 mRNA
Metformin results in increased expression of DDIT4 mRNA

PMID:25596134 PMID:32589349

NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105

G

DNA-damage-inducible transcript 4-like

multiple interactions

[Metformin co-treated with Pioglitazone] results in increased expression of DDIT4L mRNA

NCBI chr 2:226,128,273...226,131,044
Ensembl chr 2:226,128,276...226,131,375

G

DEAD-box helicase 17

increases expression

Metformin results in increased expression of DDX17 mRNA

NCBI chr 7:111,091,127...111,109,353
Ensembl chr 7:111,089,445...111,109,193

G

DEAD-box helicase 24

increases expression

Metformin results in increased expression of DDX24 mRNA

NCBI chr 6:122,564,767...122,582,032
Ensembl chr 6:122,564,767...122,581,927

G

density regulated reinitiation and release factor

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of DENR mRNA]

NCBI chr12:32,662,512...32,685,283
Ensembl chr12:32,662,516...32,683,843

G

DEP domain containing MTOR-interacting protein

multiple interactions
decreases expression

[Metformin co-treated with Pioglitazone] results in decreased expression of DEPTOR mRNA
Metformin results in decreased expression of DEPTOR mRNA

NCBI chr 7:86,514,859...86,668,817
Ensembl chr 7:86,514,988...86,667,773

G

DNA fragmentation factor subunit alpha

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of DFFA mRNA

NCBI chr 5:159,540,715...159,553,639
Ensembl chr 5:159,540,715...159,553,633

G

diacylglycerol O-acyltransferase 2

multiple interactions

Metformin inhibits the reaction [INS protein results in increased activity of DGAT2 protein]

NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428

G

diacylglycerol kinase, alpha

increases expression

Metformin results in increased expression of DGKA mRNA

NCBI chr 7:1,148,734...1,175,324
Ensembl chr 7:1,148,735...1,175,110

G

DEAH-box helicase 37

increases expression

Metformin results in increased expression of DHX37 mRNA

NCBI chr12:31,194,782...31,214,890
Ensembl chr12:31,194,859...31,216,802

G

DExH-box helicase 9

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of DHX9 mRNA]

NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069

G

diablo, IAP-binding mitochondrial protein

multiple interactions

Metformin inhibits the reaction [Acetaminophen affects the localization of DIABLO protein]

NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387

G

dihydrolipoamide S-acetyltransferase

increases expression

Metformin results in increased expression of DLAT mRNA

NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479

G

DLG associated protein 5

increases expression

Metformin results in increased expression of DLGAP5 mRNA

NCBI chr15:20,633,964...20,664,569
Ensembl chr15:20,633,966...20,664,518

G

deleted in malignant brain tumors 1

increases expression

Metformin results in increased expression of DMBT1 mRNA

NCBI chr 1:185,617,469...185,696,476
Ensembl chr 1:185,617,294...185,696,478

G

Dmx-like 2

decreases expression

Metformin results in decreased expression of DMXL2 mRNA

NCBI chr 8:54,741,164...54,884,948
Ensembl chr 8:54,741,160...54,885,161

G

DnaJ heat shock protein family (Hsp40) member B9

increases expression

Metformin results in increased expression of DNAJB9 mRNA

NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063

G

dynamin 1-like

multiple interactions

Metformin inhibits the reaction [Glucose results in increased expression of DNM1L protein]

NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482

G

dynamin binding protein

decreases expression

Metformin results in decreased expression of DNMBP mRNA

NCBI chr 1:242,736,189...242,829,431
Ensembl chr 1:242,736,189...242,802,604

G

DNA methyltransferase 1

multiple interactions

Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin] inhibits the reaction [Ovalbumin results in decreased expression of DNMT1 mRNA]]; Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin] inhibits the reaction [Ovalbumin results in decreased expression of DNMT1 protein]]

NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659

G

dipeptidase 1

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of DPEP1 mRNA]

NCBI chr19:51,209,831...51,237,004
Ensembl chr19:51,219,660...51,235,257

G

dipeptidyl peptidase 9

decreases expression

Metformin results in decreased expression of DPP9 mRNA

NCBI chr 9:1,011,347...1,046,337
Ensembl chr 9:1,011,351...1,046,541

G

dual specificity phosphatase 1

decreases expression

Metformin results in decreased expression of DUSP1 mRNA

NCBI chr10:16,680,478...16,683,275

G

dual specificity phosphatase 22

decreases expression

Metformin results in decreased expression of DUSP22 mRNA

NCBI chr17:33,780,980...33,831,241
Ensembl chr17:33,780,981...33,831,321

G

dual specificity phosphatase 4

increases expression

Metformin results in increased expression of DUSP4 mRNA

NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138

G

dual specificity phosphatase 5

increases expression

Metformin results in increased expression of DUSP5 mRNA

NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818

G

E2F transcription factor 4

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of E2F4 mRNA

NCBI chr19:33,174,396...33,181,806
Ensembl chr19:33,174,410...33,181,806

G

Epstein-Barr virus induced 3

multiple interactions
decreases expression

Metformin co-treated with metformin hydrochloride co-treated with N(gamma)-nitro-L-arginine methyl ester inhibits the reaction [pre-eclampsia increases expression of Ebi3 mRNA in peripheral blood]
Metformin decreases expression of Ebi3 mRNA in umbilical vein endothelial cells

RGD

PMID:31203154 PMID:31203154

RGD:213230155, RGD:213230155

NCBI chr 9:774,252...787,544
Ensembl chr 9:783,617...787,544

G

enoyl-CoA hydratase 1

increases expression

Metformin results in increased expression of ECH1 mRNA

NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795

G

enoyl-CoA delta isomerase 1

increases expression

Metformin results in increased expression of ECI1 mRNA

NCBI chr10:13,456,715...13,470,061
Ensembl chr10:13,456,563...13,470,061

G

ectodysplasin A2 receptor

increases expression
multiple interactions

Metformin results in increased expression of EDA2R mRNA
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of EDA2R mRNA]

PMID:25596134 PMID:29095437

NCBI chr X:62,224,763...62,269,333
Ensembl chr X:62,228,229...62,269,268

G

endothelin 1

multiple interactions

Metformin inhibits the reaction [Fructose results in increased expression of EDN1 protein]
Metformin inhibits the reaction [IL13 protein results in increased expression of EDN1 mRNA]

PMID:25108154 PMID:26497364

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

ephrin A1

decreases expression

Metformin results in decreased expression of EFNA1 mRNA

NCBI chr 2:174,681,676...174,689,061
Ensembl chr 2:174,681,682...174,690,866

G

early growth response 1

increases expression

Metformin results in increased expression of EGR1 mRNA

PMID:19664596 PMID:31324951

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

eukaryotic translation initiation factor 1

increases expression

Metformin results in increased expression of EIF1 mRNA

NCBI chr10:85,246,751...85,248,842
Ensembl chr10:85,246,764...85,427,327

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of EIF2AK3 protein]; Metformin inhibits the reaction [Glucose results in increased phosphorylation of EIF2AK3 protein]
Metformin inhibits the reaction [INS protein results in increased phosphorylation of EIF2AK3 protein]

PMID:34801538 PMID:36764371

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

eukaryotic translation initiation factor 2 subunit alpha

multiple interactions

Metformin inhibits the reaction [Glucose results in increased phosphorylation of EIF2S1 protein]
Metformin inhibits the reaction [INS protein results in increased phosphorylation of EIF2S1 protein]

PMID:34801538 PMID:36764371

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

G

eukaryotic translation initiation factor 2 subunit beta

increases expression

Metformin results in increased expression of EIF2S2 mRNA

NCBI chr 3:143,374,652...143,395,460
Ensembl chr 3:143,373,686...143,395,432

G

eukaryotic translation initiation factor 3, subunit C

increases expression

Metformin results in increased expression of EIF3C mRNA

NCBI chr 1:181,134,604...181,152,489
Ensembl chr 1:181,134,604...181,152,493

G

eukaryotic translation initiation factor 4E

decreases expression
multiple interactions

Metformin results in decreased expression of EIF4E mRNA
[Metformin co-treated with Pioglitazone] results in decreased expression of EIF4E mRNA

NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683

G

eukaryotic translation initiation factor 4E binding protein 1

decreases phosphorylation
multiple interactions

Metformin results in decreased phosphorylation of EIF4EBP1 protein
Metformin decreases phosphorylation of EIF4EBP1 protein in epithelial cell of alveolus of lung
Metformin results in decreased phosphorylation of and results in increased expression of EIF4EBP1 protein

CTD
RGD

PMID:22108913 PMID:23363784 PMID:23632475

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

E74 like ETS transcription factor 4

increases expression

Metformin results in increased expression of ELF4 mRNA

NCBI chr X:127,587,401...127,639,063
Ensembl chr X:127,590,650...127,630,200

G

ETS transcription factor ELK4

increases expression

Metformin results in increased expression of ELK4 mRNA

NCBI chr13:43,451,130...43,475,035
Ensembl chr13:43,435,843...43,475,035

G

ELOVL fatty acid elongase 6

decreases expression
affects expression

Metformin results in decreased expression of ELOVL6 protein
Metformin affects the expression of ELOVL6 mRNA

PMID:28576465 PMID:31324951

NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186

G

embigin

decreases expression

Metformin results in decreased expression of EMB mRNA

NCBI chr 2:49,070,509...49,125,042
Ensembl chr 2:49,069,087...49,125,050

G

enolase 2

increases expression

Metformin results in increased expression of ENO2 mRNA

NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980

G

ectonucleoside triphosphate diphosphohydrolase 7

increases expression

Metformin results in increased expression of ENTPD7 mRNA

NCBI chr 1:242,559,365...242,601,044
Ensembl chr 1:242,559,365...242,601,447

G

E1A binding protein p400

affects expression

Metformin affects the expression of EP400 mRNA

NCBI chr12:45,891,886...46,002,523
Ensembl chr12:45,891,916...45,998,861

G

glutamyl-prolyl-tRNA synthetase 1

increases expression

Metformin results in increased expression of EPRS1 mRNA

NCBI chr13:96,901,548...96,971,966
Ensembl chr13:96,901,575...96,971,966

G

equatorin

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of EQTN mRNA]

NCBI chr 5:109,734,495...109,762,048
Ensembl chr 5:109,728,999...109,761,840

G

erb-b2 receptor tyrosine kinase 3

decreases expression

Metformin results in decreased expression of ERBB3 mRNA

NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions

Metformin inhibits the reaction [Glucose results in increased phosphorylation of ERN1 protein]
Metformin inhibits the reaction [INS protein results in increased phosphorylation of ERN1 protein]

PMID:34801538 PMID:36764371

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

G

endoplasmic reticulum oxidoreductase 1 alpha

multiple interactions

Metformin inhibits the reaction [Glucose results in increased expression of ERO1A protein]

NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478

G

estrogen receptor 1

multiple interactions

Metformin binds to and results in decreased activity of ESR1 protein; Metformin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to POU5F1 promoter]]; Metformin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to POU5F1 promoter]]
Metformin inhibits the reaction [Testosterone results in increased expression of ESR1 mRNA]

PMID:22132214 PMID:26492952 PMID:33049310

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

multiple interactions

Metformin inhibits the reaction [Testosterone results in decreased expression of ESR2 mRNA]

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

estrogen related receptor, alpha

multiple interactions
decreases expression

Metformin inhibits the reaction [GCG protein results in increased expression of ESRRA mRNA]
Metformin results in decreased expression of ESRRA mRNA

NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268

G

FA core complex associated protein 20

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of FAAP20 mRNA]

NCBI chr 5:165,808,370...165,815,291
Ensembl chr 5:165,808,657...165,815,333

G

fatty acid binding protein 2

decreases expression

Metformin results in decreased expression of FABP2 mRNA

NCBI chr 2:211,040,032...211,044,089
Ensembl chr 2:211,040,032...211,044,089

G

fatty acid binding protein 3

increases expression

Metformin results in increased expression of FABP3 mRNA

NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718

G

fatty acid binding protein 7

increases expression

Metformin results in increased expression of FABP7 mRNA

NCBI chr20:37,123,193...37,126,725
Ensembl chr20:37,123,193...37,126,880

G

family with sequence similarity 149, member A

decreases expression

Metformin results in decreased expression of FAM149A mRNA

NCBI chr16:46,855,377...46,914,553
Ensembl chr16:46,854,635...46,912,066

G

family with sequence similarity 210, member A

increases expression

Metformin results in increased expression of FAM210A mRNA

NCBI chr18:61,846,447...61,886,123
Ensembl chr18:61,852,907...61,886,171

G

family with sequence similarity 32, member A

decreases expression

Metformin results in decreased expression of FAM32A mRNA

NCBI chr16:17,603,054...17,607,376
Ensembl chr16:17,603,946...17,607,398

G

Fas cell surface death receptor

affects expression

Metformin affects the expression of FAS mRNA

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

fatty acid synthase

decreases expression
increases expression
multiple interactions

Metformin results in decreased expression of FASN mRNA
Metformin results in increased expression of FASN mRNA
[Metformin co-treated with caffeic acid] results in decreased expression of FASN protein; Metformin inhibits the reaction [[cyhalothrin co-treated with Oleic Acid] results in increased expression of FASN protein]; Metformin inhibits the reaction [INS protein results in increased expression of FASN protein]

PMID:20956498 PMID:21870829 PMID:28576465 PMID:31324951 PMID:36529352 More...

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

fructose-bisphosphatase 1

decreases expression

Metformin results in decreased expression of FBP1 mRNA

NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071

G

F-box protein 22

increases expression

Metformin results in increased expression of FBXO22 mRNA

NCBI chr 8:55,579,906...55,595,981
Ensembl chr 8:55,579,891...55,596,148

G

F-box protein 30

increases expression

Metformin results in increased expression of FBXO30 mRNA

NCBI chr 1:5,655,341...5,671,558
Ensembl chr 1:5,655,339...5,672,441

G

F-box protein 32

decreases expression

Metformin results in decreased expression of FBXO32 mRNA

NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436

G

ferrochelatase

decreases expression

Metformin results in decreased expression of FECH mRNA

NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348

G

fibroblast growth factor 1

multiple interactions

Metformin inhibits the reaction [IL13 protein results in increased expression of FGF1 mRNA]

NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357

G

fibroblast growth factor 19

multiple interactions

[Ethinyl Estradiol co-treated with Metformin] results in decreased expression of FGF15 mRNA

NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287

G

fibroblast growth factor 21

multiple interactions

Metformin inhibits the reaction [INS protein results in decreased expression of FGF21 protein]

NCBI chr 1:96,083,360...96,084,911
Ensembl chr 1:96,083,441...96,090,454

G

FGR proto-oncogene, Src family tyrosine kinase

decreases expression

Metformin results in decreased expression of FGR mRNA

NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326

G

FIC domain protein adenylyltransferase

increases expression

Metformin results in increased expression of FICD mRNA

NCBI chr12:42,889,195...42,894,090
Ensembl chr12:42,889,194...42,894,070

G

fission, mitochondrial 1

multiple interactions

Metformin inhibits the reaction [Glucose results in increased expression of FIS1 protein]

NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377

G

FKBP prolyl isomerase 1A

multiple interactions

[Paclitaxel co-treated with Metformin] results in increased expression of FKBP1A mRNA

NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743

G

FLVCR choline and putative heme transporter 2

increases expression

Metformin results in increased expression of FLVCR2 mRNA

PMID:25596134 PMID:31324951

NCBI chr 6:105,408,355...105,472,355
Ensembl chr 6:105,408,339...105,472,353

G

flavin containing dimethylaniline monoxygenase 3

decreases expression

Metformin results in decreased expression of FMO3 mRNA

NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028

G

fibronectin 1

multiple interactions

Metformin inhibits the reaction [Dietary Fats results in increased expression of FN1 protein]
Metformin inhibits the reaction [Folic Acid results in increased expression of FN1 mRNA]; Metformin inhibits the reaction [Folic Acid results in increased expression of FN1 protein]

PMID:27551045 PMID:29380373

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

fibronectin type III domain containing 5

multiple interactions

Metformin inhibits the reaction [Dietary Fats results in decreased expression of FNDC5 mRNA]; Metformin inhibits the reaction [Dietary Fats results in decreased expression of FNDC5 protein]

NCBI chr 5:141,481,593...141,491,257
Ensembl chr 5:141,481,590...141,490,731

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
decreases expression

Metformin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of FOS protein]
Metformin results in decreased expression of FOS mRNA

PMID:20590612 PMID:31324951

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box A2

multiple interactions

[Metformin co-treated with Glucose] affects the localization of FOXA2 protein

NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326

G

forkhead box O1

decreases expression
multiple interactions

Metformin results in decreased expression of FOXO1 mRNA
Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] affects the localization of FOXO1 protein]

PMID:24428821 PMID:27270450

NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790

G

forkhead box O3

decreases expression
multiple interactions

Metformin results in decreased expression of FOXO3 mRNA
FOXO3 protein promotes the reaction [[Metformin co-treated with NVP-BKM120] results in increased cleavage of CASP3 protein]; FOXO3 protein promotes the reaction [[Metformin co-treated with NVP-BKM120] results in increased expression of BBC3 protein]

PMID:31324951 PMID:38479708

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

follicle stimulating hormone subunit beta

multiple interactions

Metformin inhibits the reaction [FSHB protein results in increased expression of CCND2 protein]; Metformin inhibits the reaction [FSHB protein results in increased expression of CCNE1 protein]; Metformin inhibits the reaction [FSHB protein results in increased expression of CYP11A1 protein]; Metformin inhibits the reaction [FSHB protein results in increased expression of CYP19A1 protein]; Metformin inhibits the reaction [FSHB protein results in increased expression of HSD3B protein]; Metformin inhibits the reaction [FSHB protein results in increased expression of STAR protein]; Metformin inhibits the reaction [FSHB protein results in increased secretion of Estradiol]; Metformin inhibits the reaction [FSHB protein results in increased secretion of Progesterone]; PRKAA1 gene mutant form inhibits the reaction [Metformin inhibits the reaction [FSHB protein results in increased expression of HSD3B protein]]; PRKAA1 gene mutant form inhibits the reaction [Metformin inhibits the reaction [FSHB protein results in increased expression of STAR protein]]; PRKAA1 gene mutant form inhibits the reaction [Metformin promotes the reaction [FSHB protein results in increased phosphorylation of PRKAA1 protein]]

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

fucosyltransferase 4

increases expression

Metformin results in increased expression of FUT4 protein

NCBI chr 8:11,586,721...11,590,682
Ensembl chr 8:11,586,721...11,590,682

G

G0/G1switch 2

increases expression

Metformin results in increased expression of G0S2 mRNA

NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions
decreases expression

Metformin inhibits the reaction [Glucose results in increased expression of G6PC1 mRNA]
Metformin results in decreased expression of G6PC1 mRNA
Metformin inhibits the reaction [INS protein results in increased expression of G6PC1 protein]

PMID:19576170 PMID:19664596 PMID:24428821 PMID:31324951 PMID:31974165 More...

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

glucose-6-phosphate dehydrogenase

increases expression

Metformin results in increased expression of G6PD mRNA

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

glutamate decarboxylase 1

multiple interactions

Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of GAD1 protein]

NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333

G

growth arrest and DNA-damage-inducible, alpha

increases expression

Metformin results in increased expression of GADD45A mRNA

PMID:19022234 PMID:25596134

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

glycyl-tRNA synthetase 1

increases expression

Metformin results in increased expression of GARS1 mRNA

NCBI chr 4:84,171,596...84,212,609
Ensembl chr 4:84,171,596...84,212,609

G

1,4-alpha-glucan branching enzyme 1

increases expression

Metformin results in increased expression of GBE1 mRNA

NCBI chr11:8,734,806...9,000,226
Ensembl chr11:8,734,820...9,000,210

G

guanylate binding protein 1

decreases expression

Metformin results in decreased expression of GBP1 mRNA

NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131
Ensembl chr 2:231,398,163...231,432,131

G

guanylate binding protein 1, pseudogene 1

decreases expression

Metformin results in decreased expression of GBP1-PS1 mRNA

NCBI chr 2:231,517,485...231,525,865
Ensembl chr 2:231,517,398...231,529,600

G

glucagon

multiple interactions

Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of GCG protein]; Metformin inhibits the reaction [GCG results in increased abundance of Glucose]
[Metformin co-treated with GCG] results in increased expression of IL1RN mRNA; Metformin inhibits the reaction [GCG protein results in increased expression of ESRRA mRNA]; Metformin inhibits the reaction [GCG protein results in increased expression of PPARGC1A mRNA]; Metformin inhibits the reaction [GCG protein results in increased expression of SIRT3 mRNA]; Metformin promotes the reaction [GCG protein results in decreased expression of IL15RA mRNA]

PMID:19002567 PMID:22117073 PMID:23166782 PMID:27270450

NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929

G

glucokinase

affects expression
multiple interactions

Metformin affects the expression of GCK mRNA
Metformin inhibits the reaction [INS protein results in decreased activity of GCK protein]; Metformin inhibits the reaction [INS protein results in decreased expression of GCK protein]
Metformin inhibits the reaction [Glucose results in decreased expression of GCK mRNA]

PMID:31324951 PMID:31974165 PMID:33651899

NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995

G

glucokinase regulator

multiple interactions

Metformin inhibits the reaction [INS protein results in increased expression of GCKR protein]

NCBI chr 6:25,044,592...25,075,834
Ensembl chr 6:25,045,100...25,075,654

G

glutamate-cysteine ligase, catalytic subunit

increases expression

Metformin results in increased expression of GCLC mRNA

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

decreases expression
increases expression

Metformin results in decreased expression of GCLM mRNA
Metformin results in increased expression of GCLM mRNA

PMID:25596134 PMID:33838154

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

glucosaminyl (N-acetyl) transferase 3, mucin type

increases expression
multiple interactions

Metformin results in increased expression of GCNT3 mRNA
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of GCNT3 mRNA]

PMID:25596134 PMID:29095437

NCBI chr 8:70,689,173...70,696,476
Ensembl chr 8:70,686,844...70,699,562

G

growth differentiation factor 15

increases expression

Metformin results in increased expression of GDF15 mRNA

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

glial fibrillary acidic protein

multiple interactions

Metformin inhibits the reaction [Olanzapine results in increased expression of GFAP mRNA]

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

ghrelin and obestatin prepropeptide

multiple interactions

Metformin inhibits the reaction [Olanzapine results in increased expression of GHRL protein]

NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621

G

growth hormone secretagogue receptor

multiple interactions

Metformin inhibits the reaction [Olanzapine results in increased expression of GHSR mRNA]

NCBI chr 2:110,268,489...110,271,865
Ensembl chr 2:110,268,489...110,271,865

G

GIMAP family P-loop NTPase domain containing 1

increases expression

Metformin results in increased expression of GIMD1 mRNA

NCBI chr 2:221,103,878...221,138,559
Ensembl chr 2:221,103,878...221,138,553

G

glutaminase

decreases expression

Metformin results in decreased expression of GLS protein

NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900

G

GDP-mannose pyrophosphorylase B

increases expression

Metformin results in increased expression of GMPPB mRNA

NCBI chr 8:108,737,429...108,740,437
Ensembl chr 8:108,693,060...108,767,286

G

guanosine monophosphate reductase

decreases expression

Metformin results in decreased expression of GMPR mRNA

NCBI chr17:19,151,820...19,189,626
Ensembl chr17:19,151,815...19,189,621

G

glycine N-methyltransferase

decreases expression

Metformin results in decreased expression of GNMT mRNA

NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434

G

golgi phosphoprotein 3-like

increases expression

Metformin results in increased expression of GOLPH3L mRNA

NCBI chr 2:183,151,941...183,183,094
Ensembl chr 2:183,153,301...183,183,083

G

golgi phosphoprotein 3-like, pseudogene 1

increases expression

Metformin results in increased expression of GOLPH3L-PS1 mRNA

NCBI chr 9:45,890,492...45,891,363

G

glutamic-oxaloacetic transaminase 1

decreases expression
multiple interactions

Metformin results in decreased expression of GOT1 mRNA
Metformin inhibits the reaction [Doxorubicin results in increased activity of GOT1 protein]

PMID:25596134 PMID:31324951 PMID:38364893

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glycerol-3-phosphate acyltransferase, mitochondrial

increases expression

Metformin results in increased expression of GPAM mRNA

NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639

G

glycerol-3-phosphate acyltransferase 3

increases expression

Metformin results in increased expression of GPAT3 mRNA

NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490

G

glycerol-3-phosphate dehydrogenase 1 like 2

increases expression

Metformin results in increased expression of GPD1L2 mRNA

NCBI chr 7:91,940,258...91,942,125
Ensembl chr 7:91,940,260...91,942,559

G

gephyrin

increases expression

Metformin results in increased expression of GPHN mRNA

NCBI chr 6:96,954,365...97,483,617
Ensembl chr 6:96,892,148...97,483,612

G

glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1

increases expression

Metformin results in increased expression of GPIHBP1 mRNA

NCBI chr 7:107,285,584...107,288,702
Ensembl chr 7:107,285,654...107,288,702

G

glycoprotein nmb

increases expression

Metformin results in increased expression of GPNMB mRNA

NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367

G

G protein-coupled receptor 22

decreases expression

Metformin results in decreased expression of GPR22 mRNA

NCBI chr 6:48,309,619...48,317,864
Ensembl chr 6:48,310,505...48,317,486

G

GPRIN family member 3

increases expression

Metformin results in increased expression of GPRIN3 mRNA

NCBI chr 4:88,572,062...88,657,369
Ensembl chr 4:88,563,607...88,657,429

G

glutamic--pyruvic transaminase

multiple interactions

Metformin inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in increased expression of GPT protein]; Metformin inhibits the reaction [Acetaminophen results in increased expression of and results in increased secretion of and results in increased activity of GPT protein]; Metformin inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; Metformin inhibits the reaction [Doxorubicin results in increased activity of GPT protein]; Metformin inhibits the reaction [Doxorubicin results in increased secretion of GPT protein]
Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased activity of GPT protein]

PMID:24717679 PMID:27562556 PMID:29614383 PMID:31743741 PMID:38364893

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glycogen synthase kinase 3 alpha

increases phosphorylation

Metformin results in increased phosphorylation of GSK3A protein

NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802

G

glycogen synthase kinase 3 beta

increases phosphorylation
multiple interactions
decreases expression

Metformin results in increased phosphorylation of GSK3B protein
Metformin inhibits the reaction [Streptozocin results in decreased phosphorylation of GSK3B protein]
Metformin results in decreased expression of GSK3B protein modified form
Metformin inhibits the reaction [[Streptozocin co-treated with Coconut Oil co-treated with Cholesterol] results in decreased phosphorylation of GSK3B protein]; Metformin inhibits the reaction [Methamphetamine results in increased expression of and results in increased phosphorylation of GSK3B protein]
AKT1 protein modified form inhibits the reaction [Metformin promotes the reaction [plantamajoside results in decreased phosphorylation of GSK3B protein]]; Metformin inhibits the reaction [cyanoginosin LR results in increased phosphorylation of GSK3B protein]; Metformin inhibits the reaction [INS protein results in decreased phosphorylation of GSK3B protein]; Metformin inhibits the reaction [INS protein results in increased expression of GSK3B protein]; Metformin promotes the reaction [plantamajoside results in decreased phosphorylation of GSK3B protein]

PMID:21054339 PMID:26835874 PMID:30742852 PMID:30928401 PMID:31877369 More...

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

gelsolin

increases expression

Metformin results in increased expression of GSN mRNA

NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402

G

G1 to S phase transition 1

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of GSPT1 mRNA]

NCBI chr10:4,362,528...4,397,215
Ensembl chr10:4,362,510...4,397,198

G

glutathione-disulfide reductase

multiple interactions
affects expression

Metformin inhibits the reaction [Carbon Tetrachloride results in decreased activity of GSR protein]
Metformin inhibits the reaction [Methamphetamine results in decreased activity of GSR protein]; Metformin inhibits the reaction [Streptozocin results in decreased activity of GSR protein]
Metformin affects the expression of GSR mRNA

PMID:24717679 PMID:25596134 PMID:30742852 PMID:35414346

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase alpha 1

multiple interactions

Metformin inhibits the reaction [Doxorubicin results in increased expression of GSTA1 mRNA]

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

glutathione S-transferase mu 2

decreases expression

Metformin results in decreased expression of GSTM2 mRNA

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase pi 1

increases expression

Metformin results in increased expression of GSTP1 mRNA

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

glycophorin A

decreases expression

Metformin results in decreased expression of GYPA mRNA

NCBI chr19:27,450,304...27,465,940
Ensembl chr19:27,450,308...27,465,822

G

glycogen synthase 1

multiple interactions

Metformin inhibits the reaction [INS protein results in decreased expression of GYS1 protein]

NCBI chr 1:95,915,443...95,935,292
Ensembl chr 1:95,915,443...95,935,292

G

H19 imprinted maternally expressed transcript

increases methylation
multiple interactions
decreases expression

Metformin increases methylation of H19 RNA in umbilical vein endothelial cells
Metformin co-treated with metformin hydrochloride co-treated with N(gamma)-nitro-L-arginine methyl ester inhibits the reaction [pre-eclampsia increases expression of H19 RNA in peripheral blood]
Metformin decreases expression of H19 RNA in umbilical vein endothelial cells

RGD

PMID:31203154 PMID:31203154 PMID:31203154

RGD:213230155, RGD:213230155, RGD:213230155

NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134

G

H1.2 linker histone, cluster member

decreases expression

Metformin results in decreased expression of H1-2 mRNA

NCBI chr17:41,391,106...41,392,597
Ensembl chr17:41,388,477...41,392,635

G

H2A.X variant histone

decreases expression
increases expression
multiple interactions

Metformin results in decreased expression of H2AX protein
Metformin results in increased expression of H2AX mRNA
[epothilone A co-treated with Metformin] results in increased expression of H2AX mRNA

PMID:23363784 PMID:29117515

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

G

histidine ammonia lyase

decreases expression

Metformin results in decreased expression of HAL mRNA

NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701

G

hepcidin antimicrobial peptide

decreases expression

Metformin results in decreased expression of HAMP mRNA

NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891

G

hepatitis A virus cellular receptor 1

multiple interactions

dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]; Metformin promotes the reaction [dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]]

NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698

G

hemoglobin subunit beta

decreases expression

Metformin results in decreased expression of HBB-B1 mRNA

NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012

G

HEAT repeat containing 6

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of HEATR6 mRNA]

NCBI chr10:68,635,048...68,665,445
Ensembl chr10:68,635,065...68,664,105

G

hemogen

decreases expression

Metformin results in decreased expression of HEMGN mRNA

NCBI chr 5:60,679,633...60,698,597
Ensembl chr 5:60,679,633...60,698,669

G

HECT and RLD domain containing E3 ubiquitin protein ligase 3

decreases expression

Metformin results in decreased expression of HERC3 mRNA

NCBI chr 4:87,952,202...88,042,492
Ensembl chr 4:87,952,274...88,042,488

G

homocysteine inducible ER protein with ubiquitin like domain 1

increases expression

Metformin results in increased expression of HERPUD1 mRNA

NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424

G

hematopoietically expressed homeobox

decreases expression

Metformin results in decreased expression of HHEX mRNA

NCBI chr 1:235,190,455...235,196,042
Ensembl chr 1:235,190,455...235,196,042

G

hypoxia inducible factor 1 subunit alpha

affects activity
multiple interactions
decreases expression

Metformin affects the activity of HIF1A protein
[Metformin co-treated with Pioglitazone] results in decreased expression of HIF1A mRNA
Metformin results in decreased expression of HIF1A mRNA

PMID:25596134 PMID:32589349

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

histone cluster 2 H3 family member C2

increases expression

Metformin results in increased expression of HIST2H3C2 mRNA

NCBI chr 2:183,837,296...183,837,721
Ensembl chr 2:183,837,303...183,837,752

G

high mobility group box 1

multiple interactions

[Simvastatin co-treated with Metformin] results in increased secretion of HMGB1 protein; necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] results in increased secretion of HMGB1 protein]

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

3-hydroxy-3-methylglutaryl-CoA reductase

decreases expression
increases expression
multiple interactions

Metformin results in decreased expression of HMGCR mRNA
Metformin results in increased expression of HMGCR mRNA
Metformin inhibits the reaction [AGT protein results in increased activity of and results in increased phosphorylation of HMGCR protein]

PMID:21870829 PMID:29499335 PMID:31324951

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

heme oxygenase 1

increases expression
decreases expression
multiple interactions
decreases response to substance

Metformin results in increased expression of HMOX1 mRNA
Metformin results in decreased expression of HMOX1 mRNA; Metformin results in decreased expression of HMOX1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Metformin results in decreased expression of HMOX1 protein]
HMOX1 protein results in decreased susceptibility to Metformin
Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]; Metformin inhibits the reaction [Doxorubicin results in increased expression of HMOX1 mRNA]; Metformin inhibits the reaction [Streptozocin results in decreased expression of HMOX1 mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of HMOX1 mRNA]

PMID:19022234 PMID:21457706 PMID:22666520 PMID:23707609 PMID:25596134 More...

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hepatocyte nuclear factor 4, alpha

decreases expression

Metformin results in decreased expression of HNF4A mRNA
Metformin results in decreased expression of HNF4A mRNA; Metformin results in decreased expression of HNF4A protein

PMID:19022234 PMID:24428821

NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320

G

heterogeneous nuclear ribonucleoprotein K

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of HNRNPK mRNA

NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997

G

hook microtubule-tethering protein 2

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of HOOK2 mRNA]

NCBI chr19:23,151,869...23,170,139
Ensembl chr19:23,151,870...23,164,181

G

HRas proto-oncogene, GTPase

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of HRAS mRNA

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

histamine receptor H 2

multiple interactions

[Cimetidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Metformin; [Famotidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Metformin; [Ranitidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Metformin

NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631

G

heat shock cognate protein 70, pseudogene 1

increases expression

Metformin results in increased expression of HSC70-PS1 mRNA

NCBI chr 2:164,044,226...164,046,344
Ensembl chr 2:164,044,261...164,046,336

G

heat shock cognate protein 70, pseudogene 2

increases expression

Metformin results in increased expression of HSC70-PS2 mRNA

NCBI chr18:16,210,467...16,212,736
Ensembl chr18:16,210,531...16,212,635

G

heat shock protein family A (Hsp70) member 5

increases expression
multiple interactions

Metformin results in increased expression of HSPA5 mRNA
Metformin inhibits the reaction [INS protein results in increased expression of HSPA5 protein]
Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of HSPA5 protein]; Metformin inhibits the reaction [Glucose results in increased expression of HSPA5 protein]
Metformin inhibits the reaction [Rotenone results in increased expression of HSPA5 mRNA]

PMID:25596134 PMID:32189544 PMID:34801538 PMID:36764371

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family A (Hsp70) member 9

multiple interactions

Metformin inhibits the reaction [INS protein results in decreased expression of HSPA9 protein]

NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292

G

heat shock protein family H (Hsp110) member 1

increases expression

Metformin results in increased expression of HSPH1 mRNA

NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224

G

HIV-1 Tat interactive protein 2

increases expression

Metformin results in increased expression of HTATIP2 mRNA

NCBI chr 1:99,473,411...99,488,632
Ensembl chr 1:99,469,245...99,488,629

G

5-hydroxytryptamine receptor 1A

multiple interactions

Metformin inhibits the reaction [Chlorpyrifos results in increased expression of HTR1A mRNA]

NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442

G

5-hydroxytryptamine receptor 2A

multiple interactions

Metformin inhibits the reaction [Chlorpyrifos results in increased expression of HTR2A mRNA]

NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928

G

hydroxylysine kinase

decreases expression

Metformin results in decreased expression of HYKK mRNA

NCBI chr 8:55,315,919...55,339,720
Ensembl chr 8:55,315,969...55,337,339

G

hypoxia up-regulated 1

increases expression

Metformin results in increased expression of HYOU1 mRNA

NCBI chr 8:44,706,073...44,718,189
Ensembl chr 8:44,706,263...44,718,186

G

isoleucyl-tRNA synthetase 1

increases expression

Metformin results in increased expression of IARS1 mRNA

PMID:25596134 PMID:31324951

NCBI chr17:14,940,919...14,987,277
Ensembl chr17:14,940,924...14,987,237

G

intercellular adhesion molecule 1

multiple interactions

Metformin inhibits the reaction [Fructose results in increased expression of ICAM1 protein modified form]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

insulin degrading enzyme

multiple interactions

Metformin inhibits the reaction [INS protein results in decreased expression of IDE protein]

NCBI chr 1:235,002,984...235,102,448
Ensembl chr 1:234,995,351...235,102,440

G

isopentenyl-diphosphate delta isomerase 1

increases expression

Metformin results in increased expression of IDI1 mRNA

NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357

G

interferon-gamma-inducible GTPase 4 like

decreases expression

Metformin results in decreased expression of IFGGA4L mRNA

NCBI chr18:53,838,426...53,854,858
Ensembl chr18:53,851,449...53,852,696

G

interferon induced transmembrane protein 3

decreases expression

Metformin results in decreased expression of IFITM3 mRNA

NCBI chr 1:196,111,026...196,112,135
Ensembl chr 1:196,111,043...196,112,203

G

interferon, alpha 1

multiple interactions

[Paclitaxel co-treated with Metformin] results in increased expression of IFNA1 mRNA

NCBI chr 5:103,097,356...103,097,925
Ensembl chr 5:103,097,356...103,097,925

G

interferon gamma

increases expression
multiple interactions

Metformin results in increased expression of IFNG protein
[Paclitaxel co-treated with Metformin] results in increased expression of IFNG mRNA

PMID:20869956 PMID:29309887

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor 1

multiple interactions

[Metformin co-treated with IGF1 protein] results in decreased expression of IGF1R mRNA; [Metformin co-treated with IGF1 protein] results in decreased expression of IGF2R mRNA; [Metformin co-treated with IGF1 protein] results in decreased expression of INSR mRNA; [Metformin co-treated with IGF1 protein] results in increased phosphorylation of AKT1 protein; [Metformin co-treated with Pioglitazone] results in decreased expression of IGF1 mRNA
Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IGF1 protein]; Metformin inhibits the reaction [Testosterone results in increased expression of IGF1 mRNA]
Metformin inhibits the reaction [IL13 protein results in increased expression of IGF1 mRNA]; Metformin inhibits the reaction [Streptozocin results in decreased expression of IGF1 protein]

PMID:21664031 PMID:23927877 PMID:26492952 PMID:26497364 PMID:32589349 More...

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor 1 receptor

multiple interactions

[Metformin co-treated with IGF1 protein] results in decreased expression of IGF1R mRNA; [Metformin co-treated with IGF2 protein] results in decreased expression of IGF1R mRNA; [Metformin co-treated with INS protein] results in decreased expression of IGF1R mRNA
Metformin inhibits the reaction [Testosterone results in increased expression of IGF1R mRNA]; Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin co-treated with Ovalbumin] results in decreased expression of IGF1R mRNA]; Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin co-treated with Ovalbumin] results in decreased expression of IGF1R protein]

PMID:21664031 PMID:26492952 PMID:36547818

NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777

G

insulin-like growth factor 2

multiple interactions

[Metformin co-treated with IGF2 protein] results in decreased expression of IGF1R mRNA; [Metformin co-treated with IGF2 protein] results in decreased expression of IGF2R mRNA; [Metformin co-treated with IGF2 protein] results in decreased expression of INSR mRNA; [Metformin co-treated with IGF2 protein] results in increased phosphorylation of AKT1 protein

NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018

G

insulin-like growth factor 2 receptor

multiple interactions
increases expression

[Metformin co-treated with IGF1 protein] results in decreased expression of IGF2R mRNA; [Metformin co-treated with IGF2 protein] results in decreased expression of IGF2R mRNA; [Metformin co-treated with INS protein] results in decreased expression of IGF2R mRNA
Metformin results in increased expression of IGF2R mRNA

PMID:21664031 PMID:25596134

NCBI chr 1:47,979,109...48,067,501
Ensembl chr 1:47,979,109...48,067,501

G

insulin-like growth factor binding protein 1

decreases expression

Metformin results in decreased expression of IGFBP1 mRNA

PMID:21316309 PMID:31324951

NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of IKBKB mRNA

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

interleukin 10

multiple interactions

Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of IL10 protein]; Metformin inhibits the reaction [Streptozocin results in decreased expression of IL10 protein]
Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of IL10 mRNA]; Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of IL10 protein]

PMID:33639173 PMID:35085591 PMID:37120126

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 13

multiple interactions

Metformin inhibits the reaction [IL13 protein results in increased expression of ARG1 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of CCL2 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of CCL24 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of CCL7 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of CCR2 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of CHIL3 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of CXCL2 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of EDN1 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of FGF1 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of IGF1 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of IL1B mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of MGL2 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of MMP10 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of MMP14 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of MMP9 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of MRC1 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of MRC1 protein]; Metformin inhibits the reaction [IL13 protein results in increased expression of PPARG mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of RETNLA mRNA]

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

interleukin 15 receptor subunit alpha

multiple interactions
decreases expression

[Metformin co-treated with Cyclic AMP] results in decreased expression of IL15RA mRNA; Metformin promotes the reaction [GCG protein results in decreased expression of IL15RA mRNA]
Metformin results in decreased expression of IL15RA mRNA

NCBI chr17:66,802,300...66,831,973
Ensembl chr17:66,802,334...66,832,278

G

interleukin 17 receptor B

decreases expression

Metformin results in decreased expression of IL17RB mRNA

NCBI chr16:5,180,431...5,194,125
Ensembl chr16:5,180,432...5,194,125

G

interleukin 1 beta

multiple interactions
increases expression

Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK10 protein]; Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]; Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK9 protein]; Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of RELA protein]; Metformin inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; Metformin inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]
Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IL1B protein]; Metformin inhibits the reaction [Chlorpyrifos results in increased expression of IL1B protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of IL1B protein]; Metformin inhibits the reaction [Dietary Fats results in increased expression of IL1B protein]; Metformin inhibits the reaction [Methamphetamine results in increased expression of IL1B protein]; Metformin inhibits the reaction [Streptozocin results in decreased expression of IL1B protein]; Metformin inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA]; Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin] inhibits the reaction [Ovalbumin results in increased expression of IL1B protein]]
Metformin inhibits the reaction [IL13 protein results in increased expression of IL1B mRNA]; Metformin inhibits the reaction [Rotenone results in increased expression of IL1B mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of IL1B protein]
Metformin results in increased expression of IL1B mRNA

PMID:16385087 PMID:21316309 PMID:26497364 PMID:27551045 PMID:27634381 More...

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor antagonist

multiple interactions
increases expression

[Metformin co-treated with GCG] results in increased expression of IL1RN mRNA; Cyclic AMP promotes the reaction [Metformin results in increased expression of IL1RN mRNA]; Metformin promotes the reaction [Cyclic AMP results in increased expression of IL1RN mRNA]

NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445

G

interleukin 33

decreases expression

Metformin results in decreased expression of IL33 mRNA

NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373

G

interleukin 6

decreases expression
multiple interactions
increases expression

Metformin results in decreased expression of IL6 mRNA
Metformin co-treated with metformin hydrochloride co-treated with N(gamma)-nitro-L-arginine methyl ester inhibits the reaction [pre-eclampsia increases expression of Il6 protein in blood serum]
Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IL6 protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of IL6 protein]; Metformin inhibits the reaction [Fructose results in increased expression of IL6 protein]; Metformin inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of IL6 protein]; Metformin inhibits the reaction [Isoproterenol results in increased expression of IL6 mRNA]; Metformin inhibits the reaction [Palmitic Acid results in increased expression of IL6 mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of IL6 protein]
3-benzyl-5-((2-nitrophenoxy)methyl)dihydrofuran-2(3H)-one inhibits the reaction [Metformin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]]; dorsomorphin inhibits the reaction [Metformin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]]; Metformin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]; Metformin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]; Metformin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Metformin inhibits the reaction [Olanzapine results in increased expression of IL6 protein]
Metformin results in increased expression of IL6 mRNA; Metformin results in increased expression of IL6 protein
Metformin inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]

CTD
RGD

PMID:16385087 PMID:20869956 PMID:20956498 PMID:21457706 PMID:21870829 More...

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

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indolethylamine N-methyltransferase

decreases expression

Metformin results in decreased expression of INMT mRNA

NCBI chr 4:84,318,197...84,322,493
Ensembl chr 4:84,318,197...84,322,493

G

insulin 1

multiple interactions
increases secretion

Metformin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased secretion of INS1 protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Coconut Oil co-treated with Cholesterol] results in increased expression of INS1 protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of INS1 protein]; Metformin inhibits the reaction [Fructose results in increased secretion of INS1 protein]; Metformin inhibits the reaction [Glucose results in increased secretion of INS1 protein]; Metformin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]
Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of INS1 protein]
Metformin results in increased secretion of INS1 protein

PMID:22627169 PMID:27634381 PMID:29991592 PMID:30256492 PMID:31877369 More...

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

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insulin 2

multiple interactions
increases expression
decreases expression

[Metformin co-treated with INS protein] results in decreased expression of IGF1R mRNA; [Metformin co-treated with INS protein] results in decreased expression of IGF2R mRNA; [Metformin co-treated with INS protein] results in decreased expression of INSR mRNA; [Metformin co-treated with INS protein] results in increased phosphorylation of AKT1 protein; Metformin inhibits the reaction [[Glucose affects the susceptibility to INS protein] which affects the uptake of Glucose]; Metformin inhibits the reaction [INS protein results in decreased activity of GCK protein]; Metformin inhibits the reaction [INS protein results in decreased expression of ATP6 protein]; Metformin inhibits the reaction [INS protein results in decreased expression of BAD protein]; Metformin inhibits the reaction [INS protein results in decreased expression of FGF21 protein]; Metformin inhibits the reaction [INS protein results in decreased expression of GCK protein]; Metformin inhibits the reaction [INS protein results in decreased expression of GYS1 protein]; Metformin inhibits the reaction [INS protein results in decreased expression of HSPA9 protein]; Metformin inhibits the reaction [INS protein results in decreased expression of IDE protein]; Metformin inhibits the reaction [INS protein results in decreased expression of IRS1 protein]; Metformin inhibits the reaction [INS protein results in decreased expression of IRS2 protein]; Metformin inhibits the reaction [INS protein results in decreased expression of MFN2 protein]; Metformin inhibits the reaction [INS protein results in decreased expression of SLC2A2 protein]; Metformin inhibits the reaction [INS protein results in decreased expression of SLC2A4 protein]; Metformin inhibits the reaction [INS protein results in decreased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [INS protein results in decreased phosphorylation of GSK3B protein]; Metformin inhibits the reaction [INS protein results in decreased phosphorylation of IRS1 protein]; Metformin inhibits the reaction [INS protein results in decreased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]; Metformin inhibits the reaction [INS protein results in increased activity of DGAT2 protein]; Metformin inhibits the reaction [INS protein results in increased expression of DDIT3 protein]; Metformin inhibits the reaction [INS protein results in increased expression of FASN protein]; Metformin inhibits the reaction [INS protein results in increased expression of G6PC1 protein]; Metformin inhibits the reaction [INS protein results in increased expression of GCKR protein]; Metformin inhibits the reaction [INS protein results in increased expression of GSK3B protein]; Metformin inhibits the reaction [INS protein results in increased expression of HSPA5 protein]; Metformin inhibits the reaction [INS protein results in increased expression of IRS1 protein]; Metformin inhibits the reaction [INS protein results in increased expression of ITPR1 protein]; Metformin inhibits the reaction [INS protein results in increased expression of MAPK8 protein]; Metformin inhibits the reaction [INS protein results in increased expression of PPARG protein]; Metformin inhibits the reaction [INS protein results in increased expression of PRKCB protein]; Metformin inhibits the reaction [INS protein results in increased expression of PTPN1 protein]; Metformin inhibits the reaction [INS protein results in increased expression of SCD protein]; Metformin inhibits the reaction [INS protein results in increased expression of SREBF1 protein]; Metformin inhibits the reaction [INS protein results in increased expression of XBP1 protein]; Metformin inhibits the reaction [INS protein results in increased phosphorylation of ACACA protein]; Metformin inhibits the reaction [INS protein results in increased phosphorylation of EIF2AK3 protein]; Metformin inhibits the reaction [INS protein results in increased phosphorylation of EIF2S1 protein]; Metformin inhibits the reaction [INS protein results in increased phosphorylation of ERN1 protein]; Metformin promotes the reaction [Glucose results in increased secretion of INS protein]; Metformin results in decreased expression of and results in decreased secretion of INS protein; Metformin results in increased expression of and results in increased secretion of INS protein
Metformin results in increased expression of INS mRNA
Metformin results in decreased expression of INS protein

PMID:1900072 PMID:15531508 PMID:18082302 PMID:21664031 PMID:21779873 More...

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

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insulin induced gene 1

increases expression

Metformin results in increased expression of INSIG1 mRNA

NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952

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insulin induced gene 2

decreases expression

Metformin results in decreased expression of INSIG2 mRNA

NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923

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insulin receptor

multiple interactions
increases phosphorylation

[Metformin co-treated with IGF1 protein] results in decreased expression of INSR mRNA; [Metformin co-treated with IGF2 protein] results in decreased expression of INSR mRNA; [Metformin co-treated with INS protein] results in decreased expression of INSR mRNA
Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin co-treated with Ovalbumin] results in decreased expression of INSR mRNA]; Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin co-treated with Ovalbumin] results in decreased expression of INSR protein]
Metformin results in increased phosphorylation of INSR protein
Metformin inhibits the reaction [Streptozocin results in decreased expression of INSR mRNA]

PMID:21664031 PMID:23927877 PMID:26835874 PMID:36547818

NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883

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interferon regulatory factor 2 binding protein 2

decreases expression

Metformin results in decreased expression of IRF2BP2 mRNA

NCBI chr19:54,559,417...54,565,096
Ensembl chr19:54,560,128...54,566,642

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interferon regulatory factor 3

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of IRF3 mRNA

NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935

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interferon regulatory factor 5

multiple interactions

[Paclitaxel co-treated with Metformin] results in increased expression of IRF5 mRNA

NCBI chr 4:58,127,577...58,140,665
Ensembl chr 4:58,127,640...58,139,267

G

interferon regulatory factor 7

multiple interactions

[Paclitaxel co-treated with Metformin] results in increased expression of IRF7 mRNA

NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832

G

insulin receptor substrate 1

multiple interactions

Metformin affects the reaction [Testosterone results in decreased expression of IRS1]; Metformin inhibits the reaction [INS protein results in decreased expression of IRS1 protein]; Metformin inhibits the reaction [INS protein results in decreased phosphorylation of IRS1 protein]; Metformin inhibits the reaction [INS protein results in increased expression of IRS1 protein]
Metformin inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of IRS1 protein]
Metformin inhibits the reaction [Streptozocin results in decreased expression of IRS1 protein]; Metformin promotes the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of IRS1 protein]

PMID:19328476 PMID:23927877 PMID:27634381 PMID:30914352 PMID:30928401 More...

NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122

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insulin receptor substrate 2

decreases expression
multiple interactions

Metformin results in decreased expression of IRS2 mRNA
Metformin inhibits the reaction [Dietary Fats results in decreased expression of IRS2 protein]
Metformin inhibits the reaction [INS protein results in decreased expression of IRS2 protein]; Metformin inhibits the reaction [Oleic Acid results in decreased expression of IRS2 protein]

PMID:31324951 PMID:36592823 PMID:36764371

NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482

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iron-sulfur cluster assembly enzyme

affects expression

Metformin affects the expression of ISCU mRNA

NCBI chr12:42,852,305...42,858,150
Ensembl chr12:42,852,305...42,858,150

G

integrin subunit beta 1

increases expression

Metformin results in increased expression of ITGB1 mRNA

NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195

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integrin subunit beta 8

increases expression

Metformin results in increased expression of ITGB8 mRNA

NCBI chr 6:140,125,002...140,208,261
Ensembl chr 6:140,127,203...140,208,476

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inositol 1,4,5-trisphosphate receptor, type 1

multiple interactions

Metformin inhibits the reaction [INS protein results in increased expression of ITPR1 protein]

NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491

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inositol 1,4,5-trisphosphate receptor, type 2

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of ITPR2 mRNA]

NCBI chr 4:179,028,594...179,434,657
Ensembl chr 4:179,027,281...179,404,164

G

JNK1/MAPK8-associated membrane protein

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of JKAMP mRNA]

NCBI chr 6:90,648,043...90,661,985
Ensembl chr 6:90,648,160...90,662,501

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Metformin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of JUN protein]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

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JunB proto-oncogene, AP-1 transcription factor subunit

decreases expression

Metformin results in decreased expression of JUNB mRNA

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035

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JunD proto-oncogene, AP-1 transcription factor subunit

increases expression

Metformin results in increased expression of JUND mRNA

NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799

G

kelch repeat and BTB domain containing 12

increases expression

Metformin results in increased expression of KBTBD12 mRNA

NCBI chr 4:121,014,636...121,088,701
Ensembl chr 4:121,016,257...121,088,443

G

Kelch-like ECH-associated protein 1

decreases expression
multiple interactions

Metformin results in decreased expression of KEAP1 mRNA
Metformin promotes the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of KEAP1 mRNA]
Metformin inhibits the reaction [Streptozocin results in increased expression of KEAP1 mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of KEAP1 protein]

PMID:25596134 PMID:33639173 PMID:37120126

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

KLF transcription factor 15

decreases expression

Metformin results in decreased expression of KLF15 mRNA

NCBI chr 4:122,965,718...122,978,403
Ensembl chr 4:122,965,807...122,978,374

G

KLF transcription factor 9

decreases expression

Metformin results in decreased expression of KLF9 mRNA

NCBI chr 1:220,700,108...220,725,110
Ensembl chr 1:220,700,108...220,725,037

G

kelch-like family member 33

decreases expression

Metformin results in decreased expression of KLHL33 mRNA

NCBI chr15:24,105,923...24,114,445
Ensembl chr15:24,105,930...24,114,438

G

KRAS proto-oncogene, GTPase

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of KRAS mRNA

NCBI chr 4:178,185,418...178,218,484

G

keratin 19

increases expression

Metformin results in increased expression of KRT19 mRNA

NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799

G

keratin 80

increases expression

Metformin results in increased expression of KRT80 mRNA

NCBI chr 7:132,463,216...132,485,134
Ensembl chr 7:132,463,218...132,485,508

G

laminin subunit gamma 2

decreases expression

Metformin results in decreased expression of LAMC2 mRNA

NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200

G

leucyl-tRNA synthetase 1

increases expression

Metformin results in increased expression of LARS1 mRNA

NCBI chr18:34,201,555...34,256,003
Ensembl chr18:34,201,549...34,255,931

G

lipocalin 2

multiple interactions

Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of LCN2 protein]

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

G

ligand dependent nuclear receptor corepressor-like

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of LCORL mRNA]

NCBI chr14:65,271,339...65,407,732
Ensembl chr14:65,271,135...65,404,174

G

lactate dehydrogenase A

multiple interactions

Metformin inhibits the reaction [Doxorubicin results in increased activity of LDHA protein]; Metformin inhibits the reaction [Doxorubicin results in increased expression of LDHA protein]; Metformin inhibits the reaction [Doxorubicin results in increased secretion of LDHA protein]

PMID:37453608 PMID:38364893

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

low density lipoprotein receptor

multiple interactions

Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of LDLR protein]
Metformin inhibits the reaction [AGT protein results in increased expression of LDLR protein]; Metformin inhibits the reaction [Hydrogen Peroxide results in increased expression of LDLR protein]

NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580

G

liver enriched antimicrobial peptide 2

increases expression

Metformin results in increased expression of LEAP2 mRNA

NCBI chr10:37,580,172...37,581,244
Ensembl chr10:37,577,855...37,581,244

G

leptin

increases expression
multiple interactions

Metformin results in increased expression of LEP protein
Metformin inhibits the reaction [Olanzapine results in increased expression of LEP protein]

PMID:20869956 PMID:32652086

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

galectin 5

decreases expression

Metformin results in decreased expression of LGALS5 mRNA

NCBI chr10:63,853,949...63,857,198
Ensembl chr10:63,853,935...63,857,153

G

luteinizing hormone subunit beta

multiple interactions

Metformin inhibits the reaction [Letrozole results in increased secretion of LHB protein]

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

leucine rich repeat and Ig domain containing 3

multiple interactions

[Paclitaxel co-treated with Metformin] results in increased expression of LINGO3 mRNA

NCBI chr 7:8,869,025...8,878,431
Ensembl chr 7:8,869,025...8,878,431

G

LIM and cysteine-rich domains 1

decreases expression

Metformin results in decreased expression of LMCD1 mRNA

NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046

G

lamin A/C

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of LMNA mRNA]

NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423

G

zinc finger protein 709-like

decreases expression

Metformin results in decreased expression of ZFP871 mRNA

NCBI chr 7:11,846,077...11,868,732
Ensembl chr 7:11,845,560...11,868,717

G

lysyl oxidase

affects expression

Metformin affects the expression of LOX mRNA

NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477

G

lysophosphatidic acid receptor 3

decreases expression

Metformin results in decreased expression of LPAR3 mRNA

NCBI chr 2:235,125,234...235,193,916
Ensembl chr 2:235,149,065...235,193,357

G

lipin 2

decreases expression

Metformin results in decreased expression of LPIN2 mRNA

NCBI chr 9:111,083,378...111,158,193
Ensembl chr 9:111,083,745...111,158,193

G

lanosterol synthase

increases expression

Metformin results in increased expression of LSS mRNA

NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762

G

listerin E3 ubiquitin protein ligase 1

decreases expression

Metformin results in decreased expression of LTN1 mRNA

NCBI chr11:26,603,903...26,660,871
Ensembl chr11:26,603,903...26,660,886

G

leucine rich adaptor protein 1-like

decreases expression

Metformin results in decreased expression of LURAP1L mRNA

NCBI chr 5:95,362,005...95,409,439
Ensembl chr 5:95,362,005...95,409,438

G

lysosomal trafficking regulator

decreases expression

Metformin results in decreased expression of LYST mRNA

NCBI chr17:86,241,384...86,443,501
Ensembl chr17:86,241,384...86,443,480

G

mitotic arrest deficient 2 like 1

affects expression

Metformin affects the expression of MAD2L1 mRNA

NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470

G

MAF bZIP transcription factor G

increases expression

Metformin results in increased expression of MAFG mRNA

NCBI chr10:105,903,307...105,911,808
Ensembl chr10:105,903,237...105,912,026

G

mago homolog B, exon junction complex subunit

increases expression

Metformin results in increased expression of MAGOHB mRNA

NCBI chr 4:165,034,131...165,041,977
Ensembl chr 4:165,034,122...165,041,967

G

mannosidase, alpha, class 1A, member 2

increases expression

Metformin results in increased expression of MAN1A2 mRNA

NCBI chr 2:187,947,484...188,096,332
Ensembl chr 2:187,951,617...188,096,332

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions

[Simvastatin co-treated with Metformin] results in increased expression of MAP1LC3B protein modified form; Chloroquine promotes the reaction [[Simvastatin co-treated with Metformin] results in increased expression of MAP1LC3B protein modified form]
Metformin inhibits the reaction [Blood Glucose results in increased lipidation of MAP1LC3B protein]

PMID:25412314 PMID:33021114

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690

G

mitogen activated protein kinase kinase 3

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of MAP2K3 mRNA

NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492

G

mitogen activated protein kinase kinase kinase 2

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of MAP3K2 mRNA

NCBI chr18:23,807,218...23,879,722
Ensembl chr18:23,807,218...23,871,433

G

mitogen activated protein kinase kinase kinase 7

multiple interactions
increases activity

[Paclitaxel co-treated with Metformin] results in decreased expression of MAP3K7 mRNA
Metformin increases activity of Map3k7 protein in cardiac muscle cells

CTD
RGD

PMID:29309887 PMID:17085580

NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597

G

mitogen activated protein kinase kinase kinase kinase 2

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of MAP4K2 mRNA]

NCBI chr 1:203,645,098...203,660,782
Ensembl chr 1:203,645,153...203,660,331

G

mitogen activated protein kinase 1

multiple interactions
decreases phosphorylation

Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
Metformin results in decreased phosphorylation of MAPK1 protein
Metformin inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein]; PRKAA1 gene mutant form inhibits the reaction [Metformin results in increased phosphorylation of MAPK1 protein]

PMID:16385087 PMID:16760380 PMID:20590612 PMID:23707609 PMID:33639173

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 10

multiple interactions

Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK10 protein]

NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201

G

mitogen activated protein kinase 14

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of MAPK14 mRNA

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation

Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
Metformin results in decreased phosphorylation of MAPK3 protein
Metformin inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK3 protein]; PRKAA1 gene mutant form inhibits the reaction [Metformin results in increased phosphorylation of MAPK3 protein]

PMID:16385087 PMID:16760380 PMID:20590612 PMID:23707609 PMID:33639173

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

Metformin inhibits the reaction [Glucose results in increased phosphorylation of MAPK8 protein]
Metformin inhibits the reaction [INS protein results in increased expression of MAPK8 protein]

PMID:34801538 PMID:36764371

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

multiple interactions

Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK9 protein]

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

MCL1 apoptosis regulator, BCL2 family member

decreases expression
multiple interactions

Metformin results in decreased expression of MCL1 protein
[Metformin co-treated with NVP-BKM120] results in decreased expression of MCL1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Metformin results in decreased expression of MCL1 protein]

PMID:33838154 PMID:38479708

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

minichromosome maintenance 10 replication initiation factor

increases expression

Metformin results in increased expression of MCM10 mRNA

NCBI chr17:73,263,788...73,288,346
Ensembl chr17:73,266,095...73,287,364

G

multiple C2 and transmembrane domain containing 2

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of MCTP2 mRNA]

NCBI chr 1:125,769,932...126,002,886
Ensembl chr 1:125,771,233...126,002,928

G

MDM2 proto-oncogene

increases expression

Metformin results in increased expression of MDM2 mRNA

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

malic enzyme 1

increases expression
decreases expression

Metformin results in increased expression of ME1 mRNA
Metformin results in decreased expression of ME1 protein

PMID:25596134 PMID:28576465 PMID:31324951

NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304

G

mediator complex subunit 29

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of MED29 mRNA]

NCBI chr 1:83,677,961...83,683,365
Ensembl chr 1:83,677,961...83,683,365

G

myocyte enhancer factor 2a

increases expression

Metformin results in increased expression of MEF2A mRNA

NCBI chr 1:120,847,874...120,982,488
Ensembl chr 1:120,850,080...120,981,948

G

myocyte enhancer factor 2B

increases expression

Metformin results in increased expression of MEF2B mRNA

NCBI chr16:19,253,008...19,269,514
Ensembl chr16:19,253,010...19,268,967

G

myocyte enhancer factor 2C

increases expression

Metformin results in increased expression of MEF2C mRNA

NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880

G

myocyte enhancer factor 2D

increases expression

Metformin results in increased expression of MEF2D mRNA

NCBI chr 2:173,606,054...173,635,620
Ensembl chr 2:173,606,490...173,634,457

G

methyltransferase 1, tRNA methylguanosine

increases expression

Metformin results in increased expression of METTL1 mRNA

NCBI chr 7:62,864,860...62,869,202
Ensembl chr 7:62,864,853...62,869,202

G

methyltransferase 22, Kin17 lysine

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of METTL22 mRNA]

NCBI chr10:7,113,602...7,130,715
Ensembl chr10:7,113,660...7,130,654

G

mitofusin 2

multiple interactions

Metformin inhibits the reaction [Glucose results in decreased expression of MFN2 protein]
Metformin inhibits the reaction [INS protein results in decreased expression of MFN2 protein]

PMID:30144576 PMID:36764371

NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342

G

MFSD2 lysolipid transporter A, lysophospholipid

affects expression

Metformin affects the expression of MFSD2A mRNA

NCBI chr 5:135,225,801...135,240,744
Ensembl chr 5:135,225,816...135,240,690

G

alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

increases expression

Metformin results in increased expression of MGAT2 mRNA

NCBI chr 6:87,656,360...87,658,849
Ensembl chr 6:87,656,349...87,658,177

G

mitochondrial calcium uptake 1

multiple interactions

Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of MICU1 mRNA]; Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of MICU1 protein]

NCBI chr20:27,668,681...27,816,322
Ensembl chr20:27,668,747...27,814,964

G

MID1 interacting protein 1

increases expression

Metformin results in increased expression of MID1IP1 mRNA

NCBI chr X:12,060,993...12,063,318
Ensembl chr X:12,060,883...12,065,774

G

microRNA 1

increases expression

Metformin results in increased expression of MIR1 mRNA

NCBI chr18:1,887,537...1,887,623

G

microRNA 146a

multiple interactions

Metformin inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary] results in decreased expression of MIR146A mRNA]

NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610

G

microRNA 148a

increases expression
multiple interactions

Metformin increases expression of MIR148A RNA in umbilical vein endothelial cells
Metformin co-treated with metformin hydrochloride co-treated with N(gamma)-nitro-L-arginine methyl ester inhibits the reaction [pre-eclampsia decreases expression of MIR148A RNA in peripheral blood]

RGD

PMID:31203154 PMID:31203154

RGD:213230155, RGD:213230155

NCBI chr 4:80,333,762...80,333,858
Ensembl chr 4:80,333,762...80,333,858

G

microRNA 152

multiple interactions

Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin] inhibits the reaction [Ovalbumin results in increased expression of MIR152 mRNA]]

NCBI chr10:81,832,936...81,833,020
Ensembl chr10:81,832,936...81,833,020

G

microRNA 155

multiple interactions

Metformin inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary] results in increased expression of MIR155 mRNA]

NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718

G

microRNA 15b

increases expression

Metformin results in increased expression of MIR15B mRNA

NCBI chr 2:153,245,200...153,245,297
Ensembl chr 2:153,245,200...153,245,297

G

microRNA 190

decreases expression

Metformin results in decreased expression of MIR190 mRNA

NCBI chr 8:67,850,987...67,851,071
Ensembl chr 8:67,850,987...67,851,071

G

microRNA 19a

multiple interactions

Metformin inhibits the reaction [Oxygen deficiency results in decreased expression of MIR19A mRNA]

NCBI chr15:92,180,912...92,180,993
Ensembl chr15:92,180,912...92,180,993

G

microRNA 200a

multiple interactions

Metformin promotes the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of MIR200A]

NCBI chr 5:166,648,494...166,648,582

G

microRNA 216a

multiple interactions
increases expression

Metformin co-treated with metformin hydrochloride co-treated with N(gamma)-nitro-L-arginine methyl ester inhibits the reaction [pre-eclampsia decreases expression of Mir216a RNA in peripheral blood]
Metformin increases expression of MIR216A RNA in umbilical vein endothelial cells

RGD

PMID:31203154 PMID:31203154

RGD:213230155, RGD:213230155

NCBI chr14:102,524,105...102,524,210
Ensembl chr14:102,524,105...102,524,210

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microRNA 29b-2

decreases expression

Metformin results in decreased expression of MIR29B2 mRNA

NCBI chr13:106,570,371...106,570,451
Ensembl chr13:106,570,367...106,570,456

G

microRNA 99b

multiple interactions

Metformin inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary] results in decreased expression of MIR99B mRNA]

NCBI chr 1:58,677,015...58,677,084
Ensembl chr 1:58,677,011...58,677,090

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membrane metallo-endopeptidase

decreases expression

Metformin results in decreased expression of MME mRNA

NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792

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matrix metallopeptidase 10

multiple interactions

Metformin inhibits the reaction [IL13 protein results in increased expression of MMP10 mRNA]

NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748

G

matrix metallopeptidase 14

multiple interactions

Metformin inhibits the reaction [IL13 protein results in increased expression of MMP14 mRNA]

NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864

G

matrix metallopeptidase 19

increases expression

Metformin results in increased expression of MMP19 mRNA

NCBI chr 7:1,221,229...1,229,555
Ensembl chr 7:1,221,343...1,229,555

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matrix metallopeptidase 2

multiple interactions
decreases expression
decreases activity

[Metformin co-treated with NVP-BKM120] results in decreased expression of MMP2 protein; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 protein]
Metformin results in decreased expression of MMP2 mRNA
Metformin results in decreased activity of MMP2 protein

PMID:20590612 PMID:22246099 PMID:38479708

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

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matrix metallopeptidase 9

multiple interactions
decreases expression
decreases activity

[Metformin co-treated with NVP-BKM120] results in decreased expression of MMP9 protein; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]
Metformin inhibits the reaction [IL13 protein results in increased expression of MMP9 mRNA]
Metformin results in decreased expression of MMP9 mRNA
Metformin results in decreased activity of MMP9 protein

PMID:20590612 PMID:22246099 PMID:26497364 PMID:38479708

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

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molybdenum cofactor sulfurase

decreases expression

Metformin results in decreased expression of MOCOS mRNA

NCBI chr18:15,931,659...15,977,415
Ensembl chr18:15,931,654...15,977,187

G

myeloperoxidase

multiple interactions

Metformin inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

mannose receptor, C type 1

multiple interactions

Metformin inhibits the reaction [IL13 protein results in increased expression of MRC1 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of MRC1 protein]; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MRC1 mRNA]; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MRC1 protein]

NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857

G

musculin

decreases expression

Metformin results in decreased expression of MSC mRNA

NCBI chr 5:4,547,335...4,553,206
Ensembl chr 5:4,547,405...4,553,203

G

methylsterol monooxygenase 1

increases expression

Metformin results in increased expression of MSMO1 mRNA

NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016

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mitochondrially encoded ATP synthase membrane subunit 6

multiple interactions

Metformin inhibits the reaction [INS protein results in decreased expression of ATP6 protein]

NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599

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mitochondrially encoded cytochrome c oxidase I

increases expression

Metformin results in increased expression of COX1 protein

NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867

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metallothionein 1

affects expression

Metformin affects the expression of MT1A mRNA; Metformin affects the expression of MT1F mRNA; Metformin affects the expression of MT1M mRNA

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049

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metallothionein 2A

affects expression

Metformin affects the expression of MT2A mRNA

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

metadherin

increases expression

Metformin results in increased expression of MTDH mRNA

NCBI chr 7:65,306,464...65,365,647
Ensembl chr 7:65,306,400...65,364,413

G

mechanistic target of rapamycin kinase

multiple interactions
decreases expression
decreases expression
decreases phosphorylation

[Metformin co-treated with Pioglitazone] results in decreased expression of MTOR mRNA; Metformin results in decreased phosphorylation of and results in increased expression of MTOR protein
Metformin results in decreased expression of MTOR protein modified form
Metformin decreases expression of MTOR protein in epithelial cell of alveolus of lung
Metformin results in decreased phosphorylation of MTOR protein

CTD
RGD

PMID:23363784 PMID:27363783 PMID:32589349 PMID:33838154 PMID:23632475

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

murinoglobulin 2

decreases expression

Metformin results in decreased expression of MUG2 mRNA

NCBI chr 4:155,164,061...155,236,894
Ensembl chr 4:155,164,011...155,236,475

G

mevalonate diphosphate decarboxylase

increases expression

Metformin results in increased expression of MVD mRNA

NCBI chr19:50,496,366...50,506,429
Ensembl chr19:50,496,367...50,507,971

G

MX dynamin like GTPase 2

increases expression

Metformin results in increased expression of MX2 mRNA

NCBI chr11:36,905,698...36,936,308
Ensembl chr11:36,906,111...36,930,342

G

MYC proto-oncogene, bHLH transcription factor

increases expression
decreases expression
multiple interactions

Metformin results in increased expression of MYC mRNA
Metformin results in decreased expression of MYC protein
[Paclitaxel co-treated with Metformin] results in decreased expression of MYC mRNA
Metformin results in decreased expression of MYC mRNA

PMID:19022234 PMID:29226720 PMID:29309887

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

MYD88, innate immune signal transduction adaptor

multiple interactions

Metformin inhibits the reaction [Isoproterenol results in increased expression of MYD88 mRNA]

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

myosin heavy chain 6

multiple interactions

Metformin inhibits the reaction [Doxorubicin results in decreased expression of MYH6 mRNA]

NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720

G

myosin heavy chain 7

multiple interactions

Metformin inhibits the reaction [Doxorubicin results in increased expression of MYH7 mRNA]

NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217

G

myocardial zonula adherens protein

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of MYZAP mRNA]

NCBI chr 8:72,155,817...72,243,036
Ensembl chr 8:72,131,530...72,243,036

G

N-acetyl-alpha-glucosaminidase

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of NAGLU mRNA]
Metformin inhibits the reaction [Streptozocin results in increased activity of NAGLU protein]

PMID:29095437 PMID:33639173

NCBI chr10:86,001,545...86,009,049
Ensembl chr10:86,001,566...86,008,972

G

nicotinamide phosphoribosyltransferase

affects expression
multiple interactions
increases expression

Metformin affects the expression of NAMPT mRNA; Metformin affects the expression of NAMPT protein
Metformin inhibits the reaction [Letrozole results in increased expression of NAMPT mRNA]
Metformin results in increased expression of NAMPT mRNA
SIRT1 protein affects the reaction [Metformin affects the expression of NAMPT mRNA]

PMID:23315983 PMID:25596134 PMID:32298659

NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100

G

asparaginyl-tRNA synthetase 1

decreases expression
increases expression

Metformin results in decreased expression of NARS1 mRNA
Metformin results in increased expression of NARS1 mRNA

PMID:25596134 PMID:31324951

NCBI chr18:57,989,308...58,005,584
Ensembl chr18:57,989,308...58,005,622

G

non-SMC condensin I complex, subunit D2

increases expression

Metformin results in increased expression of NCAPD2 mRNA

NCBI chr 4:157,968,814...157,992,314
Ensembl chr 4:157,968,815...157,992,020

G

neutrophil cytosolic factor 1

decreases expression

Metformin results in decreased expression of NCF1 mRNA

NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646

G

NADH:ubiquinone oxidoreductase core subunit S8

multiple interactions

Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NDUFS8 mRNA]

NCBI chr 1:201,140,585...201,144,573
Ensembl chr 1:201,140,585...201,144,511

G

neural precursor cell expressed, developmentally down-regulated 9

decreases expression

Metformin results in decreased expression of NEDD9 mRNA

NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019

G

NFE2 like bZIP transcription factor 1

decreases expression
multiple interactions
increases degradation

Metformin results in decreased expression of NFE2L1 mRNA; Metformin results in decreased expression of NFE2L1 protein
Metformin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NFE2L1 protein]
Metformin results in increased degradation of NFE2L1 protein

NCBI chr10:81,796,055...81,812,926
Ensembl chr10:81,800,366...81,832,318

G

NFE2 like bZIP transcription factor 2

decreases expression
multiple interactions
increases activity
affects activity

Metformin results in decreased expression of NFE2L2 mRNA; Metformin results in decreased expression of NFE2L2 protein
Metformin promotes the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of NFE2L2 protein]
Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein]; Metformin inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 protein]
Metformin results in increased activity of NFE2L2 protein
Metformin affects the activity of NFE2L2 protein
Metformin inhibits the reaction [2-tert-butylhydroquinone results in increased stability of and affects the localization of NFE2L2 protein]; Metformin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NFE2L2 protein]

PMID:22627169 PMID:23707609 PMID:25596134 PMID:30114225 PMID:33639173 More...

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of NFKB1 mRNA
Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of NFKB1 mRNA]; Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NFKB1 protein]

PMID:29309887 PMID:31100278 PMID:36999408

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

nuclear factor kappa B subunit 2

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of NFKB2 mRNA

NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213

G

NFKB inhibitor alpha

multiple interactions
decreases expression

Metformin results in decreased phosphorylation of and results in decreased degradation of NFKBIA protein
Metformin results in decreased expression of NFKBIA mRNA

PMID:21054339 PMID:31324951

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

ninein

increases expression

Metformin results in increased expression of NIN mRNA

NCBI chr 6:88,525,405...88,627,710
Ensembl chr 6:88,525,742...88,627,639

G

ninjurin 1

increases expression

Metformin results in increased expression of NINJ1 mRNA

NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704

G

neuromedin U receptor 1

decreases expression

Metformin results in decreased expression of NMUR1 mRNA

NCBI chr 9:87,033,231...87,038,070
Ensembl chr 9:87,033,279...87,036,684

G

nocturnin

affects expression

Metformin affects the expression of NOCT mRNA

NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:135,271,189...135,291,400

G

nucleotide-binding oligomerization domain containing 1

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of NOD1 mRNA

NCBI chr 4:84,060,871...84,111,668
Ensembl chr 4:84,060,880...84,111,404

G

NOP58 ribonucleoprotein

increases expression

Metformin results in increased expression of NOP58 mRNA

NCBI chr 9:61,120,939...61,144,810
Ensembl chr 9:61,120,929...61,144,810

G

nitric oxide synthase 1

affects response to substance

NOS1 protein affects the susceptibility to Metformin

NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945

G

nitric oxide synthase 2

increases response to substance
multiple interactions
increases expression

NOS2 protein results in increased susceptibility to Metformin
Metformin inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA]; Metformin inhibits the reaction [Streptozocin results in increased activity of NOS2 protein]
Metformin results in increased expression of NOS2 protein

PMID:24770553 PMID:25108154 PMID:33639173

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

multiple interactions

Metformin inhibits the reaction [Fructose results in decreased phosphorylation of NOS3 protein]; Metformin inhibits the reaction [Palmitic Acid inhibits the reaction [Acetylcholine results in increased phosphorylation of NOS3 protein]]
[Orotic Acid inhibits the reaction [Metformin results in increased phosphorylation of NOS3 protein]] which results in decreased abundance of Nitric Oxide; Orotic Acid inhibits the reaction [Metformin results in increased phosphorylation of NOS3 protein]

PMID:25108154 PMID:25601987

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

NADPH oxidase 4

multiple interactions

Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NOX4 protein]

NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406

G

NPHS1 adhesion molecule, nephrin

multiple interactions

Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in decreased expression of NPHS1 mRNA]

NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078

G

natriuretic peptide A

multiple interactions

Metformin inhibits the reaction [Glucose results in increased expression of NPPA protein]

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

neuropeptide Y

multiple interactions

Metformin inhibits the reaction [Olanzapine results in increased expression of NPY mRNA]

NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
increases expression
decreases expression

Metformin inhibits the reaction [Doxorubicin results in decreased expression of NQO1 mRNA]; Metformin inhibits the reaction [Streptozocin results in decreased expression of NQO1 mRNA]; Metformin inhibits the reaction [Streptozocin results in decreased expression of NQO1 protein]
Metformin promotes the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of NQO1 mRNA]
Metformin results in increased expression of NQO1 mRNA
Metformin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of and results in increased activity of NQO1 protein]; Metformin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of NQO1 mRNA]
Metformin results in decreased expression of NQO1 protein
Metformin results in decreased expression of NQO1 mRNA

PMID:21457706 PMID:22666520 PMID:23707609 PMID:25596134 PMID:25697376 More...

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

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nuclear receptor subfamily 0, group B, member 2

decreases expression

Metformin results in decreased expression of NR0B2 mRNA

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

G

nuclear receptor subfamily 1, group D, member 1

increases expression

Metformin results in increased expression of NR1D1 mRNA

NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705

G

nuclear receptor subfamily 1, group I, member 2

decreases expression
multiple interactions

Metformin results in decreased expression of NR1I2 mRNA
Metformin binds to and results in increased activity of NR1I2 protein
Metformin binds to and results in increased activity of NR1I2 protein; NR1I2 protein affects the susceptibility to [Pregnenolone Carbonitrile co-treated with Metformin]

PMID:19022234 PMID:21920351 PMID:33049310

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions

Metformin promotes the reaction [Phenobarbital results in increased activity of NR1I3 protein]

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

nuclear receptor subfamily 3, group C, member 1

decreases expression

Metformin results in decreased expression of NR3C1 mRNA; Metformin results in decreased expression of NR3C1 protein

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

nuclear receptor subfamily 4, group A, member 1

decreases expression

Metformin results in decreased expression of NR4A1 mRNA

NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297

G

nuclear receptor subfamily 4, group A, member 2

decreases expression

Metformin results in decreased expression of NR4A2 mRNA

NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877

G

nuclear receptor subfamily 4, group A, member 3

decreases expression

Metformin results in decreased expression of NR4A3 mRNA

NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733

G

NRAS proto-oncogene, GTPase

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of NRAS mRNA

NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626

G

nuclear respiratory factor 1

increases expression

Metformin results in increased expression of NRF1 mRNA

PMID:16380484 PMID:24428821

NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328

G

nucleoside-triphosphatase, cancer-related

decreases expression

Metformin results in decreased expression of NTPCR mRNA

NCBI chr19:53,701,496...53,715,260
Ensembl chr19:53,695,976...53,715,202

G

neurotrophic receptor tyrosine kinase 2

multiple interactions

Metformin inhibits the reaction [Streptozocin results in increased expression of NTRK2 mRNA]

NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136

G

nuclear protein 1, transcriptional regulator

increases expression

Metformin results in increased expression of NUPR1 mRNA

NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281

G

ornithine aminotransferase

decreases expression

Metformin results in decreased expression of OAT mRNA

NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682

G

O-GlcNAcase

multiple interactions

Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of OGA protein]

NCBI chr 1:244,598,285...244,633,835
Ensembl chr 1:244,598,292...244,634,359

G

8-oxoguanine DNA glycosylase

multiple interactions

Metformin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of OGG1 mRNA]

NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766

G

oxidized low density lipoprotein receptor 1

multiple interactions

Metformin affects the reaction [Dehydroepiandrosterone results in increased expression of OLR1 protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of OLR1 mRNA]

NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523

G

olfactory receptor 906

decreases expression

Metformin results in decreased expression of OLR906 mRNA

NCBI chr 7:1,821,264...1,822,202
Ensembl chr 7:1,821,264...1,822,202

G

one cut homeobox 1

decreases expression

Metformin results in decreased expression of ONECUT1 mRNA

NCBI chr 8:75,599,432...75,633,598
Ensembl chr 8:75,599,740...75,627,277

G

OPA1, mitochondrial dynamin like GTPase

multiple interactions

Metformin inhibits the reaction [Glucose results in decreased expression of OPA1 protein]

NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109

G

ORAI calcium release-activated calcium modulator 3

decreases expression

Metformin results in decreased expression of ORAI3 mRNA

NCBI chr 1:182,381,196...182,386,055
Ensembl chr 1:182,344,293...182,386,052

G

oxidative stress induced growth inhibitor 1

decreases expression
affects expression

Metformin results in decreased expression of OSGIN1 mRNA
Metformin affects the expression of OSGIN1 mRNA

PMID:25596134 PMID:31324951

NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516

G

OTU deubiquitinase, ubiquitin aldehyde binding 2

increases expression

Metformin results in increased expression of OTUB2 mRNA

NCBI chr 6:122,545,067...122,563,657
Ensembl chr 6:122,545,061...122,563,644

G

OTU deubiquitinase 1

decreases expression

Metformin results in decreased expression of OTUD1 mRNA

NCBI chr17:82,259,920...82,262,770
Ensembl chr17:82,259,840...82,262,995

G

purinergic receptor P2X 7

increases expression

Metformin results in increased expression of P2RX7 mRNA

NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619

G

prolyl 4-hydroxylase subunit beta

multiple interactions

Metformin inhibits the reaction [Glucose results in increased expression of P4HB protein]

NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500

G

pantothenate kinase 1

decreases expression

Metformin results in decreased expression of PANK1 mRNA

NCBI chr 1:232,324,718...232,395,445
Ensembl chr 1:232,328,430...232,396,829

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage
increases expression

Metformin inhibits the reaction [Dietary Fats results in increased expression of and results in increased cleavage of PARP1 protein]
Metformin results in increased cleavage of PARP1 protein
Deoxyglucose promotes the reaction [Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PARP1 protein modified form]]; Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PARP1 protein modified form]
Metformin results in increased expression of PARP1 mRNA
[epothilone A co-treated with Metformin] results in increased expression of PARP1 mRNA; plantamajoside promotes the reaction [Metformin results in increased cleavage of PARP1 protein]; Sodium Salicylate promotes the reaction [Metformin results in increased expression of PARP1 mRNA]; triciribine promotes the reaction [[epothilone A co-treated with Metformin] results in increased expression of PARP1 mRNA]

PMID:27551045 PMID:29095437 PMID:29117515 PMID:35350904

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

phosphoenolpyruvate carboxykinase 1

multiple interactions
decreases expression

Metformin inhibits the reaction [Bucladesine results in increased expression of PCK1 mRNA]; Metformin inhibits the reaction [PPARGC1A protein results in increased expression of PCK1 mRNA]
Metformin results in decreased expression of PCK1 mRNA

PMID:22117073 PMID:24428821 PMID:31324951

NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191

G

phosphodiesterase 8A

decreases expression

Metformin results in decreased expression of PDE8A mRNA

NCBI chr 1:135,166,143...135,288,986
Ensembl chr 1:135,166,237...135,288,024

G

pyruvate dehydrogenase E1 subunit alpha 1

multiple interactions

Metformin results in decreased phosphorylation of and results in increased activity of PDHA1 protein

NCBI chr X:34,700,481...34,714,309
Ensembl chr X:34,700,409...34,714,311

G

protein disulfide isomerase family A, member 5

decreases expression

Metformin results in decreased expression of PDIA5 mRNA

NCBI chr11:65,272,152...65,359,087
Ensembl chr11:65,272,155...65,359,084

G

pyruvate dehydrogenase kinase 1

affects expression
increases expression

Metformin affects the expression of PDK1 mRNA
Metformin results in increased expression of PDK1 mRNA

PMID:25596134 PMID:31324951

NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038

G

pyruvate dehydrogenase kinase 4

decreases expression

Metformin results in decreased expression of PDK4 mRNA

NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850

G

PDZ and LIM domain 1

increases expression

Metformin results in increased expression of PDLIM1 mRNA

NCBI chr 1:239,042,372...239,091,074
Ensembl chr 1:239,042,385...239,091,076

G

PDZ and LIM domain 3

decreases expression

Metformin results in decreased expression of PDLIM3 mRNA

NCBI chr16:46,352,460...46,383,680
Ensembl chr16:46,352,467...46,383,657

G

3-phosphoinositide dependent protein kinase-1

decreases expression

Metformin results in decreased expression of PDPK1 mRNA

NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623

G

p53 and DNA damage regulated 1

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PDRG1 mRNA]

NCBI chr 3:141,477,561...141,483,730
Ensembl chr 3:141,476,501...141,483,858
Ensembl chr 3:141,476,501...141,483,858

G

pancreatic and duodenal homeobox 1

multiple interactions
increases expression

[Metformin co-treated with Glucose] affects the localization of PDX1 protein
Metformin results in increased expression of PDX1 protein

NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064

G

platelet and endothelial cell adhesion molecule 1

decreases expression

Metformin decreases expression of PECAM1 protein in epithelial cell of alveolus of lung

RGD

NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116

G

proenkephalin

increases expression

Metformin results in increased expression of PENK mRNA

NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129

G

period circadian regulator 1

decreases expression

Metformin results in decreased expression of PER1 mRNA

NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

increases expression
multiple interactions

Metformin results in increased expression of PFKFB1 mRNA
PFKFB1 gene mutant form inhibits the reaction [Metformin results in decreased abundance of Glucose-6-Phosphate metabolite]; PFKFB1 gene mutant form inhibits the reaction [Metformin results in increased abundance of Glyceraldehyde 3-Phosphate metabolite]

PMID:31324951 PMID:31974165

NCBI chr X:19,508,522...19,562,165
Ensembl chr X:19,508,546...19,562,182

G

phosphoglucomutase 2

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of PGM2 mRNA]

NCBI chr14:44,166,314...44,199,828
Ensembl chr14:44,164,425...44,199,967

G

phosphoglycerate dehydrogenase

increases expression

Metformin results in increased expression of PHGDH mRNA

NCBI chr 2:185,906,962...185,936,054
Ensembl chr 2:185,906,966...185,935,944

G

phosphorylase kinase catalytic subunit gamma 1

decreases expression

Metformin results in decreased expression of PHKG1 mRNA

NCBI chr12:26,838,822...26,854,547
Ensembl chr12:26,838,968...26,852,850

G

pleckstrin homology-like domain, family A, member 3

increases expression
multiple interactions

Metformin results in increased expression of PHLDA3 mRNA
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PHLDA3 mRNA]

PMID:25596134 PMID:29095437

NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335

G

protein inhibitor of activated STAT, 2

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of PIAS2 mRNA]

NCBI chr18:70,608,034...70,714,295
Ensembl chr18:70,607,665...70,710,033

G

p53-induced death domain protein 1

increases expression

Metformin results in increased expression of PIDD1 mRNA

NCBI chr 1:196,536,815...196,542,808
Ensembl chr 1:196,536,834...196,542,699

G

phosphatidylinositol 3-kinase, catalytic subunit type 3

decreases expression
multiple interactions

Metformin results in decreased expression of PIK3C3 mRNA
[Metformin co-treated with Pioglitazone] results in decreased expression of PIK3C3 mRNA

NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

multiple interactions
decreases expression

[Metformin co-treated with Pioglitazone] results in decreased expression of PIK3CA mRNA
Metformin results in decreased expression of PIK3CA mRNA

NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta

multiple interactions

[Metformin co-treated with Pioglitazone] results in decreased expression of PIK3CB mRNA

NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma

decreases expression
multiple interactions

Metformin results in decreased expression of PIK3CG mRNA
[Metformin co-treated with Pioglitazone] results in decreased expression of PIK3CG mRNA

NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043

G

phosphoinositide-3-kinase regulatory subunit 1

increases expression
multiple interactions
decreases expression

Metformin results in increased expression of PIK3R1 mRNA
Metformin inhibits the reaction [Olanzapine results in decreased expression of PIK3R1 mRNA]
Metformin results in decreased expression of PIK3R1 mRNA

PMID:21870829 PMID:31324951 PMID:32652086

NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631

G

paired immunoglobin-like type 2 receptor alpha

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PILRA mRNA]

NCBI chr12:17,787,169...17,798,149
Ensembl chr12:17,787,127...17,798,094

G

PTEN induced kinase 1

multiple interactions

Metformin inhibits the reaction [Oleic Acid results in decreased expression of PINK1 protein]
Metformin inhibits the reaction [Dietary Fats results in decreased expression of PINK1 protein]

NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635

G

pirin

decreases expression

Metformin results in decreased expression of PIR mRNA

NCBI chr X:30,108,536...30,219,269
Ensembl chr X:30,108,538...30,219,218

G

pyruvate kinase L/R

increases expression
multiple interactions

Metformin results in increased expression of PKLR mRNA
Metformin inhibits the reaction [Glucose results in increased expression of PKLR mRNA]

PMID:31324951 PMID:31974165

NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870

G

phospholipase A2, group XIIA

affects expression

Metformin affects the expression of PLA2G12A mRNA

NCBI chr 2:218,436,497...218,452,742
Ensembl chr 2:218,436,513...218,452,740

G

plasminogen activator, tissue type

increases activity

Metformin results in increased activity of PLAT protein

NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223

G

phospholipase D1

decreases expression
multiple interactions

Metformin results in decreased expression of PLD1 mRNA
[Metformin co-treated with Pioglitazone] results in decreased expression of PLD1 mRNA

NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692

G

pleckstrin homology domain containing B1

increases expression

Metformin results in increased expression of PLEKHB1 mRNA

NCBI chr 1:154,998,798...155,013,094
Ensembl chr 1:154,998,800...155,016,142

G

perilipin 2

affects expression

Metformin affects the expression of PLIN2 mRNA

NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319

G

polo-like kinase 2

increases expression

Metformin results in increased expression of PLK2 mRNA

NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947

G

phospholipid phosphatase related 1

increases expression

Metformin results in increased expression of PLPPR1 mRNA

NCBI chr 5:63,437,457...63,725,286
Ensembl chr 5:63,437,816...63,763,835

G

phospholipid transfer protein

decreases expression

Metformin results in decreased expression of PLTP mRNA

NCBI chr 3:153,574,825...153,592,647
Ensembl chr 3:153,574,825...153,592,647

G

prostate transmembrane protein, androgen induced 1

affects expression

Metformin affects the expression of PMEPA1 mRNA

NCBI chr 3:162,011,884...162,060,343
Ensembl chr 3:162,012,751...162,060,454

G

phosphomannomutase 2

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PMM2 mRNA]

NCBI chr10:6,961,521...6,982,913
Ensembl chr10:6,961,709...6,983,098

G

patatin-like phospholipase domain containing 3

affects expression

Metformin affects the expression of PNPLA3 mRNA

NCBI chr 7:115,293,538...115,314,077
Ensembl chr 7:115,293,538...115,314,077

G

patatin-like phospholipase domain containing 6

decreases expression

Metformin results in decreased expression of PNPLA6 mRNA

NCBI chr12:1,574,387...1,603,735
Ensembl chr12:1,560,363...1,603,734

G

podocalyxin-like

increases expression

Metformin results in increased expression of PODXL mRNA

NCBI chr 4:60,135,124...60,181,829
Ensembl chr 4:60,135,109...60,181,899

G

RNA polymerase III subunit F

increases expression

Metformin results in increased expression of POLR3F mRNA

NCBI chr 3:131,908,466...131,924,838
Ensembl chr 3:131,908,466...131,924,837

G

proopiomelanocortin

multiple interactions

Metformin inhibits the reaction [Olanzapine results in decreased expression of POMC mRNA]

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

paraoxonase 1

increases response to substance

PON1 gene mutant form results in increased susceptibility to Metformin

NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360

G

POU class 5 homeobox 1

multiple interactions

Metformin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to POU5F1 promoter]]; Metformin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to POU5F1 promoter]]

NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891

G

peter pan homolog

increases expression

Metformin results in increased expression of PPAN mRNA

NCBI chr 8:19,423,908...19,427,941
Ensembl chr 8:19,423,961...19,427,938

G

peroxisome proliferator activated receptor alpha

multiple interactions
increases expression
increases activity
decreases expression

[rosiglitazone co-treated with Metformin] results in increased expression of PPARA mRNA; [rosiglitazone co-treated with Metformin] results in increased expression of PPARA protein; Metformin inhibits the reaction [Streptozocin results in decreased expression of PPARA mRNA]
Metformin results in increased expression of PPARA mRNA
Metformin results in increased activity of PPARA protein
Metformin results in decreased expression of PPARA mRNA

PMID:20823565 PMID:22117073 PMID:23166782 PMID:23927877 PMID:29991592 More...

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor gamma

decreases expression
multiple interactions
affects activity
increases expression

Metformin results in decreased expression of PPARG mRNA
Metformin inhibits the reaction [[cyhalothrin co-treated with Oleic Acid] results in increased expression of PPARG protein]; Metformin inhibits the reaction [INS protein results in increased expression of PPARG protein]
Metformin inhibits the reaction [IL13 protein results in increased expression of PPARG mRNA]
Metformin affects the activity of PPARG protein
Metformin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of PPARG protein]; Metformin inhibits the reaction [Palmitic Acid results in decreased expression of PPARG mRNA]
Metformin results in increased expression of PPARG mRNA

PMID:20724125 PMID:20956498 PMID:21870829 PMID:25108154 PMID:25596134 More...

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

PPARG coactivator 1 alpha

multiple interactions
increases expression

PRKAA1 protein affects the reaction [Metformin results in increased expression of PPARGC1A mRNA]
Metformin results in increased expression of PPARGC1A mRNA; Metformin results in increased expression of PPARGC1A protein
dorsomorphin inhibits the reaction [Metformin results in increased expression of PPARGC1A mRNA]; Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of PPARGC1A protein]; Metformin inhibits the reaction [Bucladesine results in increased expression of PPARGC1A mRNA]; Metformin inhibits the reaction [GCG protein results in increased expression of PPARGC1A mRNA]; Metformin inhibits the reaction [Glucose results in decreased expression of PPARGC1A protein]; Metformin inhibits the reaction [PPARGC1A protein results in decreased expression of TNFSF12 mRNA]; Metformin inhibits the reaction [PPARGC1A protein results in increased expression of PCK1 mRNA]; PRKAA1 protein affects the reaction [Metformin results in increased expression of PPARGC1A mRNA]; PRKAA2 protein affects the reaction [Metformin results in increased expression of PPARGC1A mRNA]; SIRT1 mutant form inhibits the reaction [Metformin results in increased expression of PPARGC1A mRNA]

PMID:15864539 PMID:16380484 PMID:22117073 PMID:23090186 PMID:24428821 More...

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

PPFIA binding protein 1

increases expression

Metformin results in increased expression of PPFIBP1 mRNA

NCBI chr 4:179,807,579...179,951,428
Ensembl chr 4:179,808,794...179,951,428

G

protein phosphatase, Mg2+/Mn2+ dependent, 1D

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PPM1D mRNA]

NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607

G

protein phosphatase, Mg2+/Mn2+ dependent, 1K

decreases expression

Metformin results in decreased expression of PPM1K mRNA

NCBI chr 4:87,612,198...87,638,993
Ensembl chr 4:87,612,204...87,636,152

G

protein phosphatase 1, regulatory subunit 15A

increases expression

Metformin results in increased expression of PPP1R15A mRNA

NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171

G

protein phosphatase 1, regulatory subunit 3C

increases expression

Metformin results in increased expression of PPP1R3C mRNA

NCBI chr 1:234,460,958...234,465,961
Ensembl chr 1:234,460,652...234,465,961

G

protein phosphatase 4, regulatory subunit 2

decreases expression

Metformin results in decreased expression of PPP4R2 mRNA

NCBI chr 4:133,454,555...133,495,486
Ensembl chr 4:133,454,555...133,495,486

G

protein regulator of cytokinesis 1

increases expression

Metformin results in increased expression of PRC1 mRNA

NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765

G

PR/SET domain 1

multiple interactions

[Paclitaxel co-treated with Metformin] results in increased expression of PRDM1 mRNA

NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488

G

peroxiredoxin 2

decreases expression

Metformin results in decreased expression of PRDX2 mRNA

NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194

G

protein kinase AMP-activated catalytic subunit alpha 1

multiple interactions
increases phosphorylation
affects response to substance

Metformin inhibits the reaction [2-chloroethyl ethyl sulfide results in decreased phosphorylation of PRKAA1 protein]; Metformin inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]; Metformin results in increased phosphorylation of and results in increased activity of PRKAA1 protein; Orotic Acid inhibits the reaction [Metformin results in increased phosphorylation of PRKAA1 protein]; PRKAA1 protein affects the reaction [Metformin inhibits the reaction [Glucose deficiency results in increased chemical synthesis of Reactive Oxygen Species]]; PRKAA1 protein affects the reaction [Metformin results in decreased expression of ABCB1 protein]; PRKAA1 protein affects the reaction [Metformin results in decreased expression of RELA protein]; PRKAA1 protein affects the reaction [Metformin results in increased expression of PPARGC1A mRNA]; PRKAA1 protein affects the reaction [Metformin results in increased expression of SOD2 mRNA]
Metformin increases expression and phosphorylation of PRKAA1 protein in epithelial cell of alveolus of lung
PRKAA1 protein affects the susceptibility to Metformin
2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Metformin results in increased phosphorylation of and results in increased activity of PRKAA1 protein]; Metformin results in increased phosphorylation of and results in increased activity of PRKAA1 protein; PRKAA1 gene mutant form inhibits the reaction [Metformin inhibits the reaction [FSHB protein results in increased expression of HSD3B protein]]; PRKAA1 gene mutant form inhibits the reaction [Metformin inhibits the reaction [FSHB protein results in increased expression of STAR protein]]; PRKAA1 gene mutant form inhibits the reaction [Metformin promotes the reaction [FSHB protein results in increased phosphorylation of PRKAA1 protein]]; PRKAA1 gene mutant form inhibits the reaction [Metformin results in decreased expression of HSD3B protein]; PRKAA1 gene mutant form inhibits the reaction [Metformin results in decreased secretion of Progesterone]; PRKAA1 gene mutant form inhibits the reaction [Metformin results in increased phosphorylation of MAPK1 protein]; PRKAA1 gene mutant form inhibits the reaction [Metformin results in increased phosphorylation of MAPK3 protein]; PRKAA1 gene mutant form inhibits the reaction [Metformin results in increased phosphorylation of PRKAA1 protein]
[[PRKAA1 gene co-treated with PRKAA2 gene] affects the susceptibility to Metformin] which results in decreased abundance of Adenosine Triphosphate; [[PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to Metformin] which results in increased abundance of Glucose-6-Phosphate; [PRKAA1 gene co-treated with PRKAA2 gene] affects the susceptibility to Metformin; [PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to Metformin; Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of and results in decreased phosphorylation of PRKAA1 protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of PRKAA1 mRNA]; Metformin results in increased phosphorylation of and results in increased activity of PRKAA1 protein; PRKAA1 protein affects the reaction [Metformin results in increased expression of PPARGC1A mRNA]

CTD
RGD

PMID:16380484 PMID:16760380 PMID:16873680 PMID:19052259 PMID:19594306 More...

NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978

G

protein kinase AMP-activated catalytic subunit alpha 2

multiple interactions
increases phosphorylation
increases activity
affects response to substance

Metformin inhibits the reaction [2-chloroethyl ethyl sulfide results in decreased phosphorylation of PRKAA2 protein]; Metformin results in increased phosphorylation of and results in increased activity of PRKAA2 protein
metformin inhibits the reaction [lipopolysaccharide decreases expression of Prkaa2 mRNA in left cardiac chamber] and decreases expression of Prkaa2 mRNA in left cardiac chamber
Metformin results in increased phosphorylation of PRKAA2 protein
Metformin results in increased activity of PRKAA2 protein
PRKAA2 protein affects the susceptibility to Metformin
2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Metformin results in increased phosphorylation of and results in increased activity of PRKAA2 protein]; Metformin results in increased phosphorylation of and results in increased activity of PRKAA2 protein
[[PRKAA1 gene co-treated with PRKAA2 gene] affects the susceptibility to Metformin] which results in decreased abundance of Adenosine Triphosphate; [[PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to Metformin] which results in increased abundance of Glucose-6-Phosphate; [PRKAA1 gene co-treated with PRKAA2 gene] affects the susceptibility to Metformin; [PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to Metformin; Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of PRKAA2 mRNA]; Metformin results in increased phosphorylation of and results in increased activity of PRKAA2 protein; PRKAA2 protein affects the reaction [Metformin results in increased expression of PPARGC1A mRNA]

CTD
RGD

PMID:16873680 PMID:18484962 PMID:19052259 PMID:19594306 PMID:20847317 More...

NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543

G

protein kinase AMP-activated non-catalytic subunit beta 2

increases expression

Metformin results in increased expression of PRKAB2 mRNA

NCBI chr 2:185,257,218...185,272,846
Ensembl chr 2:185,257,213...185,269,872

G

protein kinase AMP-activated non-catalytic subunit gamma 2

multiple interactions

Metformin inhibits the reaction [Olanzapine results in increased expression of PRKAG2 mRNA]

NCBI chr 4:10,010,890...10,252,155
Ensembl chr 4:10,010,890...10,252,142

G

protein kinase C, alpha

multiple interactions
decreases expression

[Metformin co-treated with Pioglitazone] results in decreased expression of PRKCA mRNA; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PRKCA protein]
Metformin results in decreased expression of PRKCA mRNA

PMID:20590612 PMID:32589349

NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012

G

protein kinase C, beta

decreases expression
multiple interactions

Metformin results in decreased expression of PRKCB mRNA; Metformin results in decreased expression of PRKCB protein
Metformin inhibits the reaction [INS protein results in increased expression of PRKCB protein]

PMID:15531508 PMID:36764371

NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536

G

parkin RBR E3 ubiquitin protein ligase

multiple interactions

Metformin inhibits the reaction [Oleic Acid results in decreased expression of PRKN protein]
Metformin inhibits the reaction [Dietary Fats results in decreased expression of PRKN protein]

NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555

G

prolactin

decreases secretion

Metformin results in decreased secretion of PRL protein

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

phosphoserine aminotransferase 1

increases expression

Metformin results in increased expression of PSAT1 mRNA

NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682

G

phosphatase and tensin homolog

multiple interactions

Metformin inhibits the reaction [Testosterone results in decreased expression of PTEN mRNA]

NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838

G

prostaglandin F receptor

decreases expression

Metformin results in decreased expression of PTGFR mRNA

NCBI chr 2:240,731,185...240,766,674
Ensembl chr 2:240,733,375...240,765,650

G

prostaglandin-endoperoxide synthase 2

multiple interactions
decreases expression

Metformin inhibits the reaction [Dietary Fats results in increased expression of PTGS2 protein]
Metformin results in decreased expression of PTGS2 mRNA

PMID:27551045 PMID:33838154

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine phosphatase, non-receptor type 1

multiple interactions

Metformin inhibits the reaction [INS protein results in increased expression of PTPN1 protein]

NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504

G

peroxisomal membrane protein 4

increases expression

Metformin results in increased expression of PXMP4 mRNA

NCBI chr 3:143,093,371...143,110,620
Ensembl chr 3:143,093,018...143,110,651

G

pyrroline-5-carboxylate reductase 1

increases expression

Metformin results in increased expression of PYCR1 mRNA

NCBI chr10:105,917,732...105,922,658
Ensembl chr10:105,917,680...105,922,549

G

glycogen phosphorylase L

decreases expression

Metformin results in decreased expression of PYGL mRNA

NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310

G

RAB11a, member RAS oncogene family

increases expression
multiple interactions

Metformin results in increased expression of RAB11A protein
Metformin inhibits the reaction [Ethinyl Estradiol results in decreased expression of RAB11A protein]

NCBI chr 8:65,223,698...65,246,461
Ensembl chr 8:65,222,949...65,246,525

G

RAB33A, member RAS oncogene family

increases expression

Metformin results in increased expression of RAB33A mRNA

NCBI chr X:127,694,219...127,706,378
Ensembl chr X:127,694,964...127,706,378

G

RAB5A, member RAS oncogene family

multiple interactions

Metformin promotes the reaction [APPL1 protein binds to RAB5A protein]

NCBI chr 9:6,483,906...6,512,877
Ensembl chr 9:6,484,469...6,512,873

G

RAD51 paralog C

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of RAD51C mRNA]

NCBI chr10:72,205,032...72,231,643
Ensembl chr10:72,205,032...72,231,248

G

Raf-1 proto-oncogene, serine/threonine kinase

decreases phosphorylation

Metformin results in decreased phosphorylation of RAF1 protein

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

G

retinol binding protein 4

multiple interactions

Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased secretion of RBP4 protein]

NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399

G

retinol binding protein 7

increases expression

Metformin results in increased expression of RBP7 mRNA

NCBI chr 5:159,889,723...159,894,338
Ensembl chr 5:159,889,723...159,894,339

G

RD3 like

decreases expression

Metformin results in decreased expression of RD3L mRNA

NCBI chr 6:131,042,274...131,044,178
Ensembl chr 6:131,042,185...131,044,163

G

regenerating family member 3 gamma

increases expression

Metformin results in increased expression of REG3G mRNA

NCBI chr 4:110,922,805...110,927,803
Ensembl chr 4:110,924,168...110,926,723

G

RELA proto-oncogene, NF-kB subunit

decreases localization
multiple interactions
decreases phosphorylation

Metformin results in decreased localization of RELA protein
Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased phosphorylation of RELA protein]
dorsomorphin inhibits the reaction [Metformin inhibits the reaction [Palmitic Acid results in increased phosphorylation of RELA protein]]; Metformin inhibits the reaction [Dehydroepiandrosterone affects the localization of RELA protein]; Metformin inhibits the reaction [Fructose results in increased phosphorylation of RELA protein]; Metformin inhibits the reaction [Palmitic Acid results in increased phosphorylation of RELA protein]; Niacinamide inhibits the reaction [Metformin inhibits the reaction [Palmitic Acid results in increased phosphorylation of RELA protein]]
Metformin results in decreased phosphorylation of RELA protein
[Paclitaxel co-treated with Metformin] results in decreased expression of RELA mRNA; Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of RELA protein]; Metformin inhibits the reaction [RELA protein results in increased expression of ABCB1 mRNA]; Metformin results in decreased expression of and affects the localization of RELA protein; PRKAA1 protein affects the reaction [Metformin results in decreased expression of RELA protein]

PMID:16385087 PMID:21054339 PMID:25108154 PMID:27634381 PMID:29309887 More...

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

resistin

multiple interactions

Metformin inhibits the reaction [Fructose results in increased expression of RETN protein]; Metformin inhibits the reaction [Letrozole results in increased expression of RETN mRNA]

PMID:25108154 PMID:32298659

NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620

G

ring finger and FYVE-like domain containing E3 ubiquitin protein ligase

decreases expression

Metformin results in decreased expression of RFFL mRNA

NCBI chr10:67,740,711...67,803,669
Ensembl chr10:67,740,712...67,824,434

G

similar to interferon-inducible GTPase

increases expression

Metformin results in increased expression of RGD1309362 mRNA

G

regulator of G-protein signaling 2

decreases expression

Metformin results in decreased expression of RGS2 mRNA

NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385

G

Rh blood group, D antigen

decreases expression

Metformin results in decreased expression of RHD mRNA

NCBI chr 5:147,087,479...147,121,716
Ensembl chr 5:147,087,518...147,121,715

G

ras homolog family member A

decreases expression

Metformin results in decreased expression of RHOA protein

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

G

Rho-related BTB domain containing 1

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of RHOBTB1 mRNA]

NCBI chr20:19,327,142...19,456,121
Ensembl chr20:19,327,155...19,403,012

G

RPTOR independent companion of MTOR, complex 2

multiple interactions
decreases expression

[Metformin co-treated with Pioglitazone] results in decreased expression of RICTOR mRNA
Metformin results in decreased expression of RICTOR mRNA

NCBI chr 2:55,811,877...55,903,893
Ensembl chr 2:55,811,322...55,901,426

G

receptor interacting serine/threonine kinase 1

multiple interactions

[Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]; [Simvastatin co-treated with Metformin] results in increased expression of RIPK1 protein; necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]]; RIPK3 protein affects the reaction [necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]]]

NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824

G

receptor-interacting serine-threonine kinase 2

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of RIPK2 mRNA

NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657

G

receptor-interacting serine-threonine kinase 3

multiple interactions

[Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]; necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]]; RIPK3 protein affects the reaction [necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]]]

NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121

G

RLF zinc finger

increases expression

Metformin results in increased expression of RLF mRNA

NCBI chr 5:134,711,612...134,767,274
Ensembl chr 5:134,711,619...134,767,257

G

ribonuclease L

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of RNASEL mRNA]

NCBI chr13:65,894,990...65,910,354
Ensembl chr13:65,901,459...65,908,704

G

Rho family GTPase 1

affects expression

Metformin affects the expression of RND1 mRNA

NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:129,821,311...129,828,399

G

Rho family GTPase 3

affects expression
increases expression

Metformin affects the expression of RND3 mRNA
Metformin results in increased expression of RND3 mRNA

PMID:25596134 PMID:31324951

NCBI chr 3:35,571,929...35,589,283
Ensembl chr 3:35,571,143...35,589,327

G

ring finger protein 121

increases expression

Metformin results in increased expression of RNF121 mRNA

NCBI chr 1:156,377,368...156,439,936
Ensembl chr 1:156,377,364...156,446,826

G

Ro60, Y RNA binding protein

affects expression

Metformin affects the expression of RO60 mRNA

NCBI chr13:55,499,514...55,520,504
Ensembl chr13:55,499,534...55,520,504

G

ribosomal protein S6

decreases phosphorylation
multiple interactions

Metformin results in decreased phosphorylation of RPS6 protein
Trientine inhibits the reaction [Metformin results in decreased phosphorylation of RPS6 protein]
Metformin analog results in decreased phosphorylation of RPS6 protein; Metformin results in decreased phosphorylation of RPS6 protein

PMID:22492524 PMID:23363784

NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602

G

ribosomal protein S6 kinase A2

multiple interactions
increases expression

[Metformin co-treated with Pioglitazone] results in increased expression of RPS6KA2 mRNA
Metformin results in increased expression of RPS6KA2 mRNA

NCBI chr 1:52,631,582...52,906,739
Ensembl chr 1:52,631,736...52,906,739

G

ribosomal protein S6 kinase A5

multiple interactions
decreases expression

[Metformin co-treated with Pioglitazone] results in decreased expression of RPS6KA5 mRNA
Metformin results in decreased expression of RPS6KA5 mRNA

NCBI chr 6:119,828,823...120,006,190
Ensembl chr 6:119,828,846...120,006,224

G

ribosomal protein S6 kinase B1

multiple interactions
decreases expression

3-benzyl-5-((2-nitrophenoxy)methyl)dihydrofuran-2(3H)-one inhibits the reaction [Metformin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RPS6KB1 protein]]; dorsomorphin inhibits the reaction [Metformin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RPS6KB1 protein]]; Metformin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RPS6KB1 protein]
Metformin results in decreased expression of RPS6KB1 protein modified form
[Paclitaxel co-treated with Metformin] results in decreased expression of RPS6KB1 mRNA; Metformin inhibits the reaction [cyanoginosin LR results in increased phosphorylation of RPS6KB1 protein]

PMID:29309887 PMID:29859833 PMID:33838154 PMID:34432352

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

ribonucleotide reductase regulatory subunit M2

increases expression

Metformin results in increased expression of RRM2 mRNA

NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773

G

ribonucleotide reductase regulatory TP53 inducible subunit M2B

increases expression

Metformin results in increased expression of RRM2B mRNA

NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633

G

ribosomal L1 domain containing 1

increases expression

Metformin results in increased expression of RSL1D1 mRNA

NCBI chr10:4,424,868...4,436,753
Ensembl chr10:4,397,821...4,439,593

G

reticulon 3

multiple interactions

Metformin inhibits the reaction [Glucose results in increased expression of RTN3 protein]

NCBI chr 1:204,612,675...204,669,212
Ensembl chr 1:204,612,675...204,669,275

G

RUNX family transcription factor 1

increases expression

Metformin results in increased expression of RUNX1 mRNA

NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542

G

RUNX family transcription factor 2

increases expression
multiple interactions

Metformin results in increased expression of RUNX2 protein
Metformin inhibits the reaction [BMP2 protein results in increased expression of RUNX2 mRNA]; Metformin inhibits the reaction [BMP2 protein results in increased expression of RUNX2 protein]

PMID:19594306 PMID:37409753

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

G

retinoid X receptor alpha

decreases expression

Metformin results in decreased expression of RXRA mRNA

NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712

G

spalt-like transcription factor 1

increases expression

Metformin results in increased expression of SALL1 mRNA

NCBI chr19:18,005,782...18,022,705
Ensembl chr19:18,007,503...18,022,705

G

spermatogenesis associated multipass transmembrane protein 2

increases expression

Metformin results in increased expression of SAMT2 mRNA

NCBI chr X:23,355,211...23,407,134
Ensembl chr X:23,342,423...23,358,120

G

seryl-tRNA synthetase 1

increases expression

Metformin results in increased expression of SARS1 mRNA

NCBI chr 2:196,065,543...196,081,240
Ensembl chr 2:196,065,430...196,081,277

G

spermidine/spermine N1-acetyl transferase 1

increases expression

Metformin results in increased expression of SAT1 mRNA

NCBI chr X:40,158,354...40,161,641
Ensembl chr X:40,157,046...40,196,813

G

SH3 domain binding kinase 1

increases expression

Metformin results in increased expression of SBK1 mRNA

NCBI chr 1:180,807,092...180,851,910
Ensembl chr 1:180,807,099...180,851,885

G

secretory carrier membrane protein 1

increases expression

Metformin results in increased expression of SCAMP1 mRNA

NCBI chr 2:25,433,958...25,516,734
Ensembl chr 2:25,433,959...25,516,673

G

stearoyl-CoA desaturase

multiple interactions
decreases expression

[Metformin co-treated with caffeic acid] results in decreased expression of SCD1 protein; Metformin inhibits the reaction [INS protein results in increased expression of SCD protein]
Metformin results in decreased expression of SCD1 mRNA

PMID:28576465 PMID:31324951 PMID:36764371

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

stearoyl-coenzyme A desaturase 3

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of SCD3 mRNA]

NCBI chr 1:243,093,057...243,114,451
Ensembl chr 1:243,078,774...243,114,229

G

stromal cell-derived factor 2-like 1

increases expression

Metformin results in increased expression of SDF2L1 mRNA

NCBI chr11:83,872,659...83,874,902
Ensembl chr11:83,872,659...83,874,902

G

succinate dehydrogenase complex iron sulfur subunit B

multiple interactions

Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of SDHB mRNA]

NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293

G

serine dehydratase

decreases expression

Metformin results in decreased expression of SDS mRNA

NCBI chr12:36,083,226...36,090,540
Ensembl chr12:36,083,229...36,088,203

G

Sec23 homolog B, COPII coat complex component

increases expression

Metformin results in increased expression of SEC23B mRNA

NCBI chr 3:131,939,011...131,981,489
Ensembl chr 3:131,939,337...131,981,489

G

SEC62 homolog, preprotein translocation factor

multiple interactions

Metformin inhibits the reaction [Glucose results in increased expression of SEC62 protein]

NCBI chr 2:112,570,810...112,598,198
Ensembl chr 2:112,570,819...112,601,814

G

selenoprotein P

multiple interactions

Metformin inhibits the reaction [Dexamethasone results in increased expression of SELENOP mRNA]; Metformin inhibits the reaction [Dexamethasone results in increased secretion of SELENOP protein]; Metformin inhibits the reaction [Glucose results in increased expression of SELENOP mRNA]; Metformin inhibits the reaction [Glucose results in increased secretion of SELENOP protein]

NCBI chr 2:52,498,123...52,508,409
Ensembl chr 2:52,498,339...52,508,852

G

selectin P

multiple interactions

Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin] inhibits the reaction [Ovalbumin results in increased expression of SELP protein]]

NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845

G

selenophosphate synthetase 2

multiple interactions

Metformin inhibits the reaction [Dexamethasone results in increased expression of SEPHS2 mRNA]

NCBI chr 1:181,893,146...181,895,464
Ensembl chr 1:181,892,599...181,895,497

G

serpin family C member 1

increases activity

Metformin results in increased activity of SERPINC1 protein

NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293

G

serpin family E member 1

multiple interactions

Metformin inhibits the reaction [Fructose results in increased expression of SERPINE1 protein]

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

SERTA domain containing 1

decreases expression

Metformin results in decreased expression of SERTAD1 mRNA

NCBI chr 1:82,775,692...82,778,961
Ensembl chr 1:82,775,252...82,779,091

G

sestrin 1

decreases expression

Metformin results in decreased expression of SESN1 mRNA

NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697

G

sestrin 2

multiple interactions
decreases expression

[Metformin co-treated with Rotenone] results in increased expression of SESN2 protein
Metformin results in decreased expression of SESN2 mRNA

PMID:26031332 PMID:31324951

NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260

G

senataxin

decreases expression

Metformin results in decreased expression of SETX mRNA

NCBI chr 3:12,428,091...12,480,801
Ensembl chr 3:12,427,635...12,480,803

G

seizure related 6 homolog

decreases expression

Metformin results in decreased expression of SEZ6 mRNA

NCBI chr10:62,818,931...62,868,686
Ensembl chr10:62,819,069...62,868,671

G

stratifin

increases expression

Metformin results in increased expression of SFN mRNA

NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314

G

serum/glucocorticoid regulated kinase 1

affects expression

Metformin affects the expression of SGK1 mRNA

NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283

G

serum/glucocorticoid regulated kinase 2

increases expression

Metformin results in increased expression of SGK2 mRNA

NCBI chr 3:151,644,102...151,669,480
Ensembl chr 3:151,644,102...151,669,480

G

SH3-domain binding protein 5

decreases expression

Metformin results in decreased expression of SH3BP5 mRNA

NCBI chr16:6,583,462...6,678,344
Ensembl chr16:6,583,465...6,698,975

G

siah E3 ubiquitin protein ligase 2

decreases expression

Metformin results in decreased expression of SIAH2 mRNA

NCBI chr 2:142,913,924...142,931,752
Ensembl chr 2:142,914,003...142,931,950

G

salt-inducible kinase 1

decreases expression

Metformin results in decreased expression of SIK1 mRNA

PMID:25596134 PMID:31324951

NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991

G

sirtuin 1

multiple interactions
increases phosphorylation
increases expression

SIRT1 protein affects the reaction [Metformin affects the expression of NAMPT mRNA]
Metformin results in increased phosphorylation of SIRT1 protein
Metformin results in increased expression of SIRT1 mRNA
Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of SIRT1 protein]; Metformin inhibits the reaction [Ethinyl Estradiol results in decreased phosphorylation of SIRT1 protein]; Metformin inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]; SIRT1 mutant form inhibits the reaction [Metformin results in increased expression of PPARGC1A mRNA]
Metformin results in increased expression of SIRT1 protein
[Niacinamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Metformin; Metformin inhibits the reaction [Fructose results in decreased expression of SIRT1 protein]; Metformin promotes the reaction [Arsenic Trioxide results in increased expression of SIRT1 protein]

PMID:23090186 PMID:23166782 PMID:23315983 PMID:24428821 PMID:24687991 More...

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

sirtuin 2

increases expression

Metformin results in increased expression of SIRT2 mRNA; Metformin results in increased expression of SIRT2 protein

NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975

G

sirtuin 3

multiple interactions
increases expression
decreases expression
decreases response to substance

Metformin inhibits the reaction [GCG protein results in increased expression of SIRT3 mRNA]; SIRT3 promotes the reaction [Metformin inhibits the reaction [Cisplatin affects the localization of SLC2A4 protein]]; SIRT3 protein inhibits the reaction [Metformin results in decreased abundance of Adenosine Triphosphate]; SIRT3 protein promotes the reaction [Metformin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]]; SIRT3 protein promotes the reaction [Metformin inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]]; SIRT3 protein promotes the reaction [Metformin inhibits the reaction [Cisplatin results in increased expression of BAX protein]]
Metformin results in increased expression of and results in increased activity of SIRT3 protein
[Arsenic Trioxide co-treated with Metformin] results in increased expression of SIRT3 protein; Metformin inhibits the reaction [Cisplatin results in decreased expression of SIRT3 mRNA]; Metformin inhibits the reaction [Cisplatin results in decreased expression of SIRT3 protein]
Metformin results in increased expression of SIRT3 protein
Metformin results in decreased expression of SIRT3 mRNA; Metformin results in decreased expression of SIRT3 protein
SIRT3 protein results in decreased susceptibility to Metformin

PMID:23166782 PMID:24687991 PMID:30385301 PMID:33147367 PMID:36800006

NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808

G

sirtuin 4

increases expression

Metformin results in increased expression of SIRT4 mRNA

NCBI chr12:41,125,533...41,139,440
Ensembl chr12:41,131,262...41,139,439

G

sirtuin 5

decreases expression

Metformin results in decreased expression of SIRT5 protein

NCBI chr17:21,310,028...21,337,137
Ensembl chr17:21,310,028...21,337,101

G

sirtuin 7

decreases expression

Metformin results in decreased expression of SIRT7 mRNA

NCBI chr10:105,896,476...105,903,301
Ensembl chr10:105,896,476...105,903,172

G

SIVA1, apoptosis-inducing factor

decreases expression

Metformin results in decreased expression of SIVA1 mRNA

NCBI chr 6:131,705,323...131,709,697
Ensembl chr 6:131,705,323...131,709,690

G

S-phase kinase associated protein 2

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of SKP2 mRNA]

NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338

G

solute carrier family 10 member 1

decreases expression
multiple interactions

Metformin results in decreased expression of SLC10A1 mRNA; Metformin results in decreased expression of SLC10A1 protein
[Ethinyl Estradiol co-treated with Metformin] results in decreased expression of SLC10A1 mRNA; [Metformin co-treated with Ethinyl Estradiol] results in decreased expression of SLC10A1 protein

NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670

G

solute carrier family 10 member 2

multiple interactions
increases expression

Metformin inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLC10A2 protein]
Metformin results in increased expression of SLC10A2 protein

NCBI chr16:84,386,528...84,409,475
Ensembl chr16:84,374,862...84,409,475

G

solute carrier family 12, member 8

increases expression

Metformin results in increased expression of SLC12A8 mRNA

NCBI chr11:67,116,876...67,266,548
Ensembl chr11:67,116,877...67,266,834

G

solute carrier family 15 member 1

multiple interactions
increases expression

Metformin inhibits the reaction [rosiglitazone results in increased expression of and results in increased activity of SLC15A1 protein]; Metformin results in decreased activity of and results in decreased expression of SLC15A1 protein
Metformin results in increased expression of SLC15A1 mRNA
Metformin inhibits the reaction [rosiglitazone results in increased activity of SLC15A1 protein]

NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545

G

solute carrier family 16 member 10

decreases expression

Metformin results in decreased expression of SLC16A10 mRNA

NCBI chr20:43,454,819...43,567,839
Ensembl chr20:43,459,709...43,567,839

G

solute carrier family 16, member 6

increases expression

Metformin results in increased expression of SLC16A6 mRNA

NCBI chr10:94,424,377...94,447,482
Ensembl chr10:94,426,244...94,448,779

G

solute carrier family 19 member 2

decreases expression

Metformin results in decreased expression of SLC19A2 mRNA

NCBI chr13:76,601,975...76,616,175
Ensembl chr13:76,601,900...76,616,172

G

solute carrier family 19 member 3

multiple interactions
increases uptake

Amprolium inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Chloroquine inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Famotidine inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Metformin inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Metformin inhibits the reaction [SLC19A3 protein results in increased uptake of Thiamine]; Phenformin inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Verapamil inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]

NCBI chr 9:84,275,722...84,299,368
Ensembl chr 9:84,277,024...84,299,337

G

solute carrier family 1 member 4

increases expression

Metformin results in increased expression of SLC1A4 mRNA

NCBI chr14:94,530,801...94,560,190
Ensembl chr14:94,529,084...94,560,418

G

solute carrier family 22 member 1

multiple interactions
increases uptake
increases response to substance

Imipramine inhibits the reaction [SLC22A1 protein results in increased uptake of Metformin]; Metformin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
SLC22A1 protein results in increased susceptibility to Metformin

PMID:16141367 PMID:20956498 PMID:25106415

NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678

G

solute carrier family 22 member 2

multiple interactions
increases transport
increases uptake
decreases transport
affects transport

Bisoprolol inhibits the reaction [SLC22A2 protein results in increased uptake of Metformin]; carvedilol inhibits the reaction [SLC22A2 protein results in increased uptake of Metformin]; Metformin inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Metoprolol inhibits the reaction [SLC22A2 protein results in increased uptake of Metformin]; Ondansetron inhibits the reaction [SLC22A2 protein results in increased uptake of Metformin]; Phenoxybenzamine inhibits the reaction [SLC22A2 protein affects the transport of Metformin]; Propranolol inhibits the reaction [SLC22A2 protein results in increased uptake of Metformin]
SLC22A2 protein results in increased transport of Metformin
SLC22A2 protein mutant form results in decreased transport of Metformin

PMID:16141367 PMID:18230276 PMID:18728938 PMID:19740083 PMID:24001450 More...

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 22 member 3

multiple interactions
increases uptake

carvedilol inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin]; Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin]; Imipramine inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin]; Metformin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Verapamil inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin]
[1-Methyl-4-phenylpyridinium results in decreased activity of [SLC22A3 protein co-treated with SLC47A1 protein]] which results in decreased transport of Metformin

PMID:16141367 PMID:21697722 PMID:23562376

NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612

G

solute carrier family 22 member 4

decreases expression
multiple interactions

Metformin results in decreased expression of SLC22A4 mRNA
Metformin inhibits the reaction [SLC22A4 protein results in increased abundance of Doxorubicin]

PMID:31324951 PMID:37453608 PMID:38364893

NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720

G

solute carrier family 22 member 5

increases expression
multiple interactions

Metformin results in increased expression of SLC22A5 mRNA
Metformin inhibits the reaction [SLC22A5 protein results in increased abundance of Doxorubicin]

PMID:31324951 PMID:37453608 PMID:38364893

NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309

G

solute carrier family 25 member 20

decreases expression

Metformin results in decreased expression of SLC25A20 mRNA

NCBI chr 8:109,365,056...109,386,512
Ensembl chr 8:109,365,002...109,386,512

G

solute carrier family 25 member 37

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of SLC25A37 mRNA]

NCBI chr15:44,534,280...44,576,697
Ensembl chr15:44,536,727...44,577,199

G

solute carrier family 25, member 47

increases expression

Metformin results in increased expression of SLC25A47 mRNA

NCBI chr 6:127,767,365...127,773,000
Ensembl chr 6:127,767,305...127,773,005

G

solute carrier family 29 member 4

multiple interactions

Metformin inhibits the reaction [SLC29A4 protein results in increased abundance of Doxorubicin]

NCBI chr12:11,853,540...11,884,660
Ensembl chr12:11,853,540...11,874,834

G

solute carrier family 2 member 2

increases response to substance
multiple interactions
increases phosphorylation

SLC2A2 intron SNP results in increased susceptibility to Metformin
Metformin inhibits the reaction [INS protein results in decreased expression of SLC2A2 protein]
Metformin results in increased phosphorylation of SLC2A2 protein

PMID:26835874 PMID:27500523 PMID:36764371

NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933

G

solute carrier family 2 member 4

multiple interactions
decreases expression
increases expression

Metformin affects the reaction [Testosterone results in decreased expression of SLC2A4]; Metformin inhibits the reaction [INS protein results in decreased expression of SLC2A4 protein]
Metformin inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased expression of SLC2A4 protein]; SIRT3 promotes the reaction [Metformin inhibits the reaction [Cisplatin affects the localization of SLC2A4 protein]]
Metformin results in decreased expression of SLC2A4 mRNA
Metformin results in increased expression of SLC2A4 mRNA; Metformin results in increased expression of SLC2A4 protein
Metformin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of SLC2A4 protein]; Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of SLC2A4 protein]; Metformin inhibits the reaction [Cisplatin affects the localization of SLC2A4 protein]; Metformin inhibits the reaction [Letrozole results in decreased expression of SLC2A4 mRNA]

PMID:15864539 PMID:18322300 PMID:19080170 PMID:19328476 PMID:20724125 More...

NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565

G

solute carrier family 2 member 5

increases expression

Metformin results in increased expression of SLC2A5 mRNA

NCBI chr 5:160,583,055...160,609,994
Ensembl chr 5:160,583,234...160,611,106

G

solute carrier family 3 member 2

increases expression

Metformin results in increased expression of SLC3A2 mRNA

NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931

G

solute carrier family 41, member 3

decreases expression

Metformin results in decreased expression of SLC41A3 mRNA

NCBI chr 4:123,109,555...123,154,766
Ensembl chr 4:123,112,748...123,154,766

G

solute carrier family 46, member 3

decreases expression

Metformin results in decreased expression of SLC46A3 mRNA

NCBI chr12:7,140,610...7,157,093
Ensembl chr12:7,140,668...7,157,092

G

solute carrier family 47 member 1

affects abundance
decreases uptake
multiple interactions
increases secretion
increases uptake

SLC47A1 protein affects the abundance of Metformin
SLC47A1 protein polymorphism results in decreased uptake of Metformin
[1-Methyl-4-phenylpyridinium results in decreased activity of [SLC22A3 protein co-treated with SLC47A1 protein]] which results in decreased transport of Metformin
SLC47A1 protein results in increased secretion of Metformin
SLC47A1 protein results in increased uptake of Metformin
Cadmium inhibits the reaction [SLC47A1 protein results in increased uptake of Metformin]; Ondansetron inhibits the reaction [SLC47A1 protein results in increased uptake of Metformin]
Cadmium inhibits the reaction [SLC47A1 protein results in increased uptake of Metformin]; Metformin inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Ondansetron inhibits the reaction [SLC47A1 protein results in increased uptake of Metformin]; Pyrimethamine inhibits the reaction [SLC47A1 protein results in increased uptake of Metformin]

PMID:19172157 PMID:21991918 PMID:22419765 PMID:23562376 PMID:24001450 More...

NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637

G

solute carrier family 47 member 2

increases uptake
multiple interactions

SLC47A2 protein results in increased uptake of Metformin
Cadmium inhibits the reaction [SLC47A2 protein results in increased uptake of Metformin]; Metformin inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Ondansetron inhibits the reaction [SLC47A2 protein results in increased uptake of Metformin]

PMID:22419765 PMID:24001450 PMID:27871888

NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904

G

solute carrier family 4 member 1 (Diego blood group)

decreases expression

Metformin results in decreased expression of SLC4A1 mRNA

NCBI chr10:87,306,865...87,323,132
Ensembl chr10:87,306,872...87,323,117

G

solute carrier family 6 member 6

increases expression

Metformin results in increased expression of SLC6A6 mRNA

NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875

G

solute carrier family 6 member 9

increases expression

Metformin results in increased expression of SLC6A9 mRNA

PMID:25596134 PMID:31324951

NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728

G

solute carrier family 7 member 1

increases expression

Metformin results in increased expression of SLC7A1 mRNA

NCBI chr12:6,628,288...6,703,849
Ensembl chr12:6,628,007...6,703,849

G

solute carrier family 7 member 11

increases expression

Metformin results in increased expression of SLC7A11 mRNA

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

G

solute carrier family 7 member 5

increases expression

Metformin results in increased expression of SLC7A5 mRNA

NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823

G

solute carrier organic anion transporter family, member 1a4

decreases expression
multiple interactions
increases expression

Metformin results in decreased expression of SLCO1A2 mRNA
[Ethinyl Estradiol co-treated with Metformin] results in decreased expression of SLCO1A4 mRNA
Metformin results in increased expression of SLCO1A4 mRNA

PMID:19022234 PMID:34058177

NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573

G

solute carrier organic anion transporter family, member 2b1

decreases expression

Metformin results in decreased expression of SLCO2B1 mRNA

NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353

G

small cell adhesion glycoprotein

decreases expression

Metformin results in decreased expression of SMAGP mRNA

NCBI chr 7:131,720,260...131,738,711
Ensembl chr 7:131,718,740...131,738,691

G

snail family transcriptional repressor 2

increases expression

Metformin results in increased expression of SNAI2 mRNA

NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200

G

small nucleolar RNA, H/ACA box 30

decreases expression

Metformin results in decreased expression of SNORA30 mRNA

NCBI chr 1:182,139,388...182,139,521
Ensembl chr 1:182,139,388...182,139,521

G

small nucleolar RNA, C/D box 13

decreases expression

Metformin results in decreased expression of SNORD13 mRNA

NCBI chr16:60,988,909...60,989,013
Ensembl chr16:60,988,909...60,989,013

G

superoxide dismutase 1

multiple interactions

Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of SOD1 protein]
Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of SOD1 protein]

PMID:35085591 PMID:36999408 PMID:37120126

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

increases expression
multiple interactions

Metformin results in increased expression of SOD2 mRNA
PRKAA1 protein affects the reaction [Metformin results in increased expression of SOD2 mRNA]

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

SON DNA and RNA binding protein

decreases expression

Metformin results in decreased expression of SON mRNA

NCBI chr11:30,850,890...30,923,167
Ensembl chr11:30,892,005...30,923,167

G

sortilin related receptor 1

decreases expression

Metformin results in decreased expression of SORL1 mRNA

NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513

G

Sp1 transcription factor

multiple interactions
decreases expression

Metformin inhibits the reaction [SP1 protein results in increased expression of AHR protein]
Metformin results in decreased expression of SP1 protein

PMID:25110054 PMID:26317792

NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961

G

Sp3 transcription factor

decreases expression

Metformin results in decreased expression of SP3 protein

NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342

G

Sp4 transcription factor

decreases expression

Metformin results in decreased expression of SP4 protein

NCBI chr 6:139,187,458...139,252,741
Ensembl chr 6:139,192,147...139,252,126

G

Sp7 transcription factor

multiple interactions

Metformin inhibits the reaction [BMP2 protein results in increased expression of SP7 mRNA]; Metformin inhibits the reaction [BMP2 protein results in increased expression of SP7 protein]

NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847

G

splA/ryanodine receptor domain and SOCS box containing 1

increases expression

Metformin results in increased expression of SPSB1 mRNA

NCBI chr 5:160,358,292...160,418,541
Ensembl chr 5:160,358,308...160,418,468

G

sequestosome 1

increases expression
multiple interactions
decreases expression

Metformin results in increased expression of SQSTM1 mRNA
Metformin inhibits the reaction [Blood Glucose results in decreased expression of SQSTM1 protein]
Metformin inhibits the reaction [Dietary Fats results in increased expression of SQSTM1 protein]
Metformin results in decreased expression of SQSTM1 protein
[Simvastatin co-treated with Metformin] results in decreased expression of SQSTM1 protein; Chloroquine inhibits the reaction [[Simvastatin co-treated with Metformin] results in decreased expression of SQSTM1 protein]; Hydroxychloroquine inhibits the reaction [Metformin inhibits the reaction [Galactose results in increased expression of SQSTM1 protein]]; Metformin inhibits the reaction [Galactose results in increased expression of SQSTM1 protein]; Metformin inhibits the reaction [Oleic Acid results in increased expression of SQSTM1 protein]; plantamajoside promotes the reaction [Metformin results in decreased expression of SQSTM1 protein]

PMID:25412314 PMID:25596134 PMID:29426000 PMID:33021114 PMID:35350904 More...

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

steroid 5 alpha-reductase 3

decreases expression

Metformin results in decreased expression of SRD5A3 mRNA

NCBI chr14:32,046,408...32,060,796
Ensembl chr14:32,046,408...32,060,747

G

sterol regulatory element binding transcription factor 1

multiple interactions
decreases expression

[Metformin co-treated with caffeic acid] results in decreased expression of SREBF1 protein; Metformin inhibits the reaction [[cyhalothrin co-treated with Oleic Acid] results in increased expression of SREBF1 protein]; Metformin inhibits the reaction [INS protein results in increased expression of SREBF1 protein]
Metformin results in decreased expression of SREBF1 mRNA
Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SREBF1 mRNA]; Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SREBF1 protein]

PMID:28576465 PMID:31100278 PMID:31324951 PMID:36529352 PMID:36764371

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

sterol regulatory element binding transcription factor 2

multiple interactions

Buthionine Sulfoximine inhibits the reaction [Metformin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of SREBF2 protein]]; Metformin inhibits the reaction [AGT protein results in increased cleavage of and affects the localization of SREBF2 protein]; Metformin inhibits the reaction [AGT protein results in increased expression of SREBF2 protein]; Metformin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of SREBF2 protein]
Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased cleavage of SREBF2 protein]

NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848

G

spermidine synthase

increases expression

Metformin results in increased expression of SRM mRNA

NCBI chr 5:159,025,875...159,029,076
Ensembl chr 5:159,025,873...159,029,405

G

serine racemase

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of SRR mRNA]

NCBI chr10:59,769,563...59,786,688
Ensembl chr10:59,769,571...59,787,011

G

somatostatin

increases expression

Metformin results in increased expression of SST mRNA

NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 2

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of ST3GAL2 mRNA]

NCBI chr19:38,888,851...38,939,874
Ensembl chr19:38,923,999...38,939,869

G

steroidogenic acute regulatory protein

multiple interactions

Metformin inhibits the reaction [FSHB protein results in increased expression of STAR protein]; PRKAA1 gene mutant form inhibits the reaction [Metformin inhibits the reaction [FSHB protein results in increased expression of STAR protein]]

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

serine/threonine kinase 11

multiple interactions

Metformin inhibits the reaction [2-chloroethyl ethyl sulfide results in decreased phosphorylation of STK11 protein]

NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315

G

spermatid perinuclear RNA binding protein

increases expression

Metformin results in increased expression of STRBP mRNA

NCBI chr 3:21,328,310...21,467,753
Ensembl chr 3:21,337,855...21,414,949

G

sulfatase 2

decreases expression

Metformin results in decreased expression of SULF2 mRNA

NCBI chr 3:154,822,079...154,904,566
Ensembl chr 3:154,822,085...154,904,415

G

sulfotransferase family 4A, member 1

increases expression

Metformin results in increased expression of SULT4A1 mRNA

NCBI chr 7:115,216,066...115,240,156
Ensembl chr 7:115,216,066...115,240,085

G

TATA-box binding protein associated factor 15

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of TAF15 mRNA]

NCBI chr10:68,272,921...68,304,951
Ensembl chr10:68,272,969...68,304,949

G

transaldolase 1

decreases expression

Metformin results in decreased expression of TALDO1 mRNA

NCBI chr 1:196,493,634...196,503,965
Ensembl chr 1:196,493,589...196,503,974

G

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2

decreases expression

Metformin results in decreased expression of TANC2 mRNA

NCBI chr10:90,553,124...90,873,477
Ensembl chr10:90,553,002...90,868,756

G

TAO kinase 1

increases expression

Metformin results in increased expression of TAOK1 mRNA

NCBI chr10:62,373,072...62,465,295
Ensembl chr10:62,381,404...62,465,766

G

TBC1 domain family, member 4

multiple interactions

Metformin inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of TBC1D4 protein]

NCBI chr15:78,256,030...78,434,168
Ensembl chr15:78,257,121...78,434,265

G

TBCC domain containing 1

increases expression

Metformin results in increased expression of TBCCD1 mRNA

NCBI chr11:78,168,386...78,205,314
Ensembl chr11:78,168,388...78,205,523

G

T-box transcription factor 3

increases expression

Metformin results in increased expression of TBX3 mRNA

NCBI chr12:36,879,924...36,894,849
Ensembl chr12:36,881,445...36,893,708

G

transcription elongation factor A like 7

increases expression

Metformin results in increased expression of TCEAL7 mRNA

NCBI chr X:99,228,405...99,230,551
Ensembl chr X:99,228,458...99,230,543

G

t-complex 11 like 2

decreases expression

Metformin results in decreased expression of TCP11L2 mRNA

NCBI chr 7:19,150,241...19,185,135
Ensembl chr 7:19,150,252...19,185,095

G

tryptophan 2,3-dioxygenase

multiple interactions
decreases expression

Metformin inhibits the reaction [Dexamethasone results in increased expression of TDO2 mRNA]; Metformin inhibits the reaction [Dexamethasone results in increased expression of TDO2 protein]
Metformin results in decreased expression of TDO2 mRNA; Metformin results in decreased expression of TDO2 protein

NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511

G

telomere maintenance 2

multiple interactions
increases expression

[Metformin co-treated with Pioglitazone] results in increased expression of TELO2 mRNA
Metformin results in increased expression of TELO2 mRNA

NCBI chr10:14,120,491...14,135,729
Ensembl chr10:14,120,818...14,135,698

G

transcription factor A, mitochondrial

increases expression

Metformin results in increased expression of TFAM mRNA

NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292

G

transcription factor binding to IGHM enhancer 3

increases expression

Metformin results in increased expression of TFE3 mRNA

NCBI chr X:14,729,547...14,742,830
Ensembl chr X:14,729,550...14,742,571

G

transferrin receptor

increases expression

Metformin results in increased expression of TFRC mRNA

NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257

G

transforming growth factor, beta 1

increases expression
multiple interactions

Metformin results in increased expression of TGFB1 mRNA
Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of TGFB1 mRNA]; Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of TGFB1 protein]; Metformin inhibits the reaction [Folic Acid results in increased expression of TGFB1 mRNA]; Metformin inhibits the reaction [Folic Acid results in increased expression of TGFB1 protein]
dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TGFB1 protein]]; Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TGFB1 protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TGFB1 protein]; Metformin inhibits the reaction [Blood Glucose results in increased expression of TGFB1 protein]

PMID:19022234 PMID:29380373 PMID:30551545 PMID:33021114 PMID:37120126

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tyrosine hydroxylase

multiple interactions

Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TH protein]

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

G

thyroid hormone responsive

increases expression

Metformin results in increased expression of THRSP mRNA

NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075

G

translocase of inner mitochondrial membrane 17b

affects expression

Metformin affects the expression of TIMM17B mRNA

NCBI chr X:14,596,330...14,603,491
Ensembl chr X:14,594,577...14,603,416

G

TIMP metallopeptidase inhibitor 3

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of TIMP3 mRNA]

NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839

G

TCDD-inducible poly(ADP-ribose) polymerase

increases expression

Metformin results in increased expression of TIPARP mRNA

NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327

G

triokinase and FMN cyclase

increases expression

Metformin results in increased expression of TKFC mRNA

NCBI chr 1:207,238,230...207,253,035
Ensembl chr 1:207,236,557...207,252,737

G

toll-like receptor 1

multiple interactions

[Paclitaxel co-treated with Metformin] results in increased expression of TLR1 mRNA

NCBI chr14:43,384,127...43,396,765
Ensembl chr14:43,384,932...43,397,125

G

toll-like receptor 2

multiple interactions

[Paclitaxel co-treated with Metformin] results in increased expression of TLR2 mRNA

NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630

G

toll-like receptor 3

multiple interactions

[Paclitaxel co-treated with Metformin] results in increased expression of TLR3 mRNA

NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545

G

toll-like receptor 4

multiple interactions

Metformin affects the reaction [Dehydroepiandrosterone results in increased expression of TLR4 protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of TLR4 mRNA]; Metformin inhibits the reaction [Isoproterenol results in increased expression of TLR4 mRNA]
[Paclitaxel co-treated with Metformin] results in decreased expression of TLR4 mRNA

PMID:24842192 PMID:27634381 PMID:29309887

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

toll-like receptor 5

multiple interactions

[Paclitaxel co-treated with Metformin] results in increased expression of TLR5 mRNA

NCBI chr13:94,634,778...94,658,992
Ensembl chr13:94,634,801...94,657,738

G

toll-like receptor 6

multiple interactions

[Paclitaxel co-treated with Metformin] results in increased expression of TLR6 mRNA

NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685

G

toll-like receptor 7

multiple interactions

[Paclitaxel co-treated with Metformin] results in increased expression of TLR7 mRNA

NCBI chr X:27,027,380...27,054,309
Ensembl chr X:27,027,425...27,054,754

G

toll-like receptor 8

multiple interactions

[Paclitaxel co-treated with Metformin] results in increased expression of TLR8 mRNA

NCBI chr X:27,091,780...27,116,092
Ensembl chr X:27,091,778...27,116,549

G

transmembrane protein 140

decreases expression

Metformin results in decreased expression of TMEM140 mRNA

NCBI chr 4:63,536,477...63,547,478
Ensembl chr 4:63,536,168...63,548,455

G

transmembrane protein 71

decreases expression

Metformin results in decreased expression of TMEM71 mRNA

NCBI chr 7:98,276,975...98,323,161
Ensembl chr 7:98,276,975...98,315,858

G

tropomodulin 4

increases expression

Metformin results in increased expression of TMOD4 mRNA

NCBI chr 2:182,695,709...182,700,540
Ensembl chr 2:182,695,709...182,700,540

G

tumor necrosis factor

decreases expression
multiple interactions
increases expression

Metformin results in decreased expression of TNF mRNA
Metformin co-treated with metformin hydrochloride co-treated with N(gamma)-nitro-L-arginine methyl ester inhibits the reaction [pre-eclampsia increases expression of Tnf protein in blood serum]
[Metformin co-treated with Rosiglitazone co-treated with Valsartan co-treated with Ezetimibe] inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; [Metformin co-treated with Rosiglitazone co-treated with Valsartan] inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; [Metformin co-treated with Rosiglitazone] promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TNF protein]]; Metformin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TNF protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TNF protein]; Metformin inhibits the reaction [Chlorpyrifos results in increased expression of TNF protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of TNF protein]; Metformin inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; Metformin inhibits the reaction [Fructose results in increased expression of TNF protein]; Metformin inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of TNF protein]; Metformin inhibits the reaction [Isoproterenol results in increased expression of TNF mRNA]; Metformin inhibits the reaction [Methamphetamine results in increased expression of TNF protein]; Metformin inhibits the reaction [Palmitic Acid results in increased expression of TNF mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin] inhibits the reaction [Ovalbumin results in increased expression of TNF protein]]
dorsomorphin inhibits the reaction [Metformin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of TNF mRNA]; Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of TNF protein]; Metformin inhibits the reaction [AGT protein results in increased secretion of TNF protein]; Metformin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Metformin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; Metformin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Metformin inhibits the reaction [Olanzapine results in increased expression of TNF protein]; Metformin inhibits the reaction [Rotenone results in increased expression of TNF mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of TNF protein]
[Paclitaxel co-treated with Metformin] results in decreased expression of TNF mRNA; Metformin inhibits the reaction [TNF protein results in increased expression of ABCB1 mRNA]; Metformin inhibits the reaction [TNF protein results in increased expression of ABCB1 protein]
Metformin results in increased expression of TNF mRNA; Metformin results in increased expression of TNF protein

CTD
RGD

PMID:16865780 PMID:19022234 PMID:20869956 PMID:21054339 PMID:21457706 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 8

increases expression

Metformin results in increased expression of TNFAIP8 mRNA

NCBI chr18:43,183,854...43,299,512
Ensembl chr18:43,183,916...43,299,517

G

TNF receptor superfamily member 10b

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of TNFRSF10A mRNA

NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467

G

TNF receptor superfamily member 1A

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of TNFRSF1A mRNA

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

TNF receptor superfamily member 21

increases expression
multiple interactions

Metformin results in increased expression of TNFRSF21 mRNA
[Paclitaxel co-treated with Metformin] results in decreased expression of TNFRSF21 mRNA

PMID:25596134 PMID:29309887

NCBI chr 9:17,879,156...17,954,085
Ensembl chr 9:17,879,156...17,954,085

G

tumor necrosis factor receptor superfamily, member 22

increases expression

Metformin results in increased expression of TNFRSF10B mRNA

NCBI chr 1:198,840,452...198,860,713
Ensembl chr 1:198,840,453...198,856,309

G

TNF receptor superfamily member 25

multiple interactions

[Paclitaxel co-treated with Metformin] results in increased expression of TNFRSF25 mRNA

NCBI chr 5:162,621,669...162,626,341
Ensembl chr 5:162,622,075...162,626,341

G

TNF receptor superfamily member 9

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of TNFRSF9 mRNA

NCBI chr 5:161,381,662...161,408,003
Ensembl chr 5:161,381,662...161,408,000

G

TNF superfamily member 12

multiple interactions

Metformin inhibits the reaction [PPARGC1A protein results in decreased expression of TNFSF12 mRNA]

NCBI chr10:54,403,870...54,413,213
Ensembl chr10:54,403,870...54,413,213

G

tumor protein p53

affects activity
decreases expression
multiple interactions

Metformin affects the activity of TP53 protein
Metformin results in decreased expression of TP53 protein
[Hydrogen Peroxide co-treated with Metformin] results in decreased expression of TP53 protein; [Metformin co-treated with NVP-BKM120] results in increased expression of TP53 mRNA; [Metformin co-treated with NVP-BKM120] results in increased expression of TP53 protein
Metformin increases expression and phosphorylation of TP53 protein in epithelial cell of alveolus of lung

CTD
RGD

PMID:25596134 PMID:29185360 PMID:38479708 PMID:23632475

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tumor protein p53 inducible nuclear protein 1

increases expression
decreases expression

Metformin results in increased expression of TP53INP1 mRNA
Metformin results in decreased expression of TP53INP1 mRNA

NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968

G

two pore segment channel 1

decreases expression

Metformin results in decreased expression of TPCN1 mRNA

NCBI chr12:35,972,813...36,029,632
Ensembl chr12:35,972,846...36,029,626

G

TNFRSF1A-associated via death domain

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of TRADD mRNA

NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638

G

Tnf receptor-associated factor 2

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of TRAF2 mRNA

NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538

G

Tnf receptor-associated factor 3

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of TRAF3 mRNA

NCBI chr 6:130,199,696...130,307,168
Ensembl chr 6:130,206,484...130,305,481

G

Tnf receptor associated factor 4

multiple interactions

[Paclitaxel co-treated with Metformin] results in decreased expression of TRAF4 mRNA

NCBI chr10:63,054,169...63,060,284
Ensembl chr10:63,054,181...63,060,284

G

TRAF type zinc finger domain containing 1

decreases expression

Metformin results in decreased expression of TRAFD1 mRNA

NCBI chr12:35,165,606...35,179,525
Ensembl chr12:35,165,606...35,179,525

G

tripartite motif-containing 21

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of TRIM21 mRNA]

NCBI chr 1:156,964,896...156,987,504
Ensembl chr 1:156,964,913...156,987,440

G

tripartite motif-containing 39

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of TRIM39 mRNA]

NCBI chr20:2,003,320...2,017,175
Ensembl chr20:1,983,533...2,020,117

G

transient receptor potential cation channel, subfamily C, member 1

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of TRPC1 mRNA]

NCBI chr 8:96,263,322...96,314,220
Ensembl chr 8:96,263,329...96,314,276

G

tsukushi, small leucine rich proteoglycan

affects expression

Metformin affects the expression of TSKU mRNA

NCBI chr 1:152,660,259...152,671,682
Ensembl chr 1:152,656,693...152,672,588

G

tetraspanin 12

decreases expression

Metformin results in decreased expression of TSPAN12 mRNA

NCBI chr 4:50,313,768...50,389,246
Ensembl chr 4:50,313,772...50,389,246

G

thioredoxin interacting protein

multiple interactions

Hydroxychloroquine inhibits the reaction [Metformin inhibits the reaction [Galactose results in increased expression of TXNIP protein]]; Metformin inhibits the reaction [Galactose results in increased expression of TXNIP protein]
Metformin inhibits the reaction [Glucose results in increased expression of TXNIP mRNA]

PMID:29426000 PMID:31974165

NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886

G

thioredoxin reductase 1

increases expression

Metformin results in increased expression of TXNRD1 mRNA

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

G

UDP-N-acetylglucosamine pyrophosphorylase 1 like 1

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of UAP1L1 mRNA]

NCBI chr 3:8,172,335...8,180,505
Ensembl chr 3:8,173,216...8,180,443

G

ubiquitin-conjugating enzyme E2B

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of UBE2B mRNA]

NCBI chr10:36,248,434...36,263,379
Ensembl chr10:36,248,438...36,264,665

G

ubiquitin-conjugating enzyme E2G 2

decreases expression

Metformin results in decreased expression of UBE2G2 mRNA

NCBI chr20:10,983,734...11,005,468
Ensembl chr20:10,983,742...11,005,447

G

uncoupling protein 2

increases expression

Metformin results in increased expression of UCP2 mRNA; Metformin results in increased expression of UCP2 protein

PMID:22815988 PMID:34302933

NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611

G

UDP glucuronosyltransferase family 2 member A3

increases expression

Metformin results in increased expression of UGT2A3 mRNA

NCBI chr14:20,572,793...20,590,795
Ensembl chr14:20,572,808...20,590,729

G

unc-51 like autophagy activating kinase 1

increases expression
multiple interactions

Metformin results in increased expression of ULK1 mRNA
[Metformin co-treated with Pioglitazone] results in increased expression of ULK1 mRNA

NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966

G

unc-51 like autophagy activating kinase 2

increases expression

Metformin results in increased expression of ULK2 mRNA

NCBI chr10:46,451,578...46,530,462
Ensembl chr10:46,454,030...46,530,407

G

unk like zinc finger

decreases expression

Metformin results in decreased expression of UNKL mRNA

NCBI chr10:14,206,125...14,252,226
Ensembl chr10:14,206,189...14,252,225

G

ubiquinol-cytochrome c reductase binding protein

multiple interactions

Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of UQCRB mRNA]

NCBI chr 7:63,814,784...63,820,150
Ensembl chr 7:63,814,797...63,820,150

G

ubiquitin specific peptidase 3

increases expression

Metformin results in increased expression of USP3 mRNA

NCBI chr 8:67,078,249...67,154,109
Ensembl chr 8:67,079,927...67,154,111

G

valyl-tRNA synthetase 1

increases expression

Metformin results in increased expression of VARS1 mRNA

NCBI chr20:3,805,774...3,820,468
Ensembl chr20:3,805,776...3,820,298

G

vascular endothelial growth factor A

decreases expression

Metformin results in decreased expression of VEGFA mRNA

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vascular endothelial growth factor B

increases expression

Metformin results in increased expression of VEGFB mRNA

NCBI chr 1:204,172,297...204,178,046
Ensembl chr 1:204,172,225...204,177,944

G

vestigial-like family member 4

decreases expression

Metformin results in decreased expression of VGLL4 mRNA

NCBI chr 4:147,925,630...148,038,519
Ensembl chr 4:147,927,034...148,038,471

G

vimentin

decreases expression
multiple interactions

Metformin results in decreased expression of VIM protein
[Metformin co-treated with NVP-BKM120] results in decreased expression of VIM protein; Metformin inhibits the reaction [BMP2 protein results in increased expression of VIM mRNA]

PMID:35248696 PMID:37409753 PMID:38479708

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

vanin 1

multiple interactions

Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of VNN1 mRNA]

NCBI chr 1:21,537,084...21,547,395
Ensembl chr 1:21,537,094...21,547,395

G

VPS53 subunit of GARP complex

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of VPS53 mRNA]

NCBI chr10:60,919,820...61,038,674
Ensembl chr10:60,919,820...61,038,676

G

visinin-like 1

decreases expression

Metformin results in decreased expression of VSNL1 mRNA

NCBI chr 6:34,038,641...34,159,479
Ensembl chr 6:34,038,642...34,159,479

G

tryptophanyl-tRNA synthetase 1

increases expression

Metformin results in increased expression of WARS1 mRNA

NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269

G

WW and C2 domain containing 2

increases expression

Metformin results in increased expression of WWC2 mRNA

NCBI chr16:44,258,372...44,421,815
Ensembl chr16:44,258,372...44,421,812

G

X-box binding protein 1

affects activity
multiple interactions
affects expression

Metformin affects the activity of XBP1 protein
Metformin inhibits the reaction [Glucose results in increased expression of XBP1 mRNA]
Metformin inhibits the reaction [Rotenone results in increased expression of XBP1 mRNA]
[Paclitaxel co-treated with Metformin] results in decreased expression of XBP1 mRNA; Metformin inhibits the reaction [INS protein results in increased expression of XBP1 protein]
Metformin affects the expression of XBP1 mRNA

PMID:25596134 PMID:29309887 PMID:32189544 PMID:34801538 PMID:36764371

NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693

G

XPC complex subunit, DNA damage recognition and repair factor

decreases expression
increases expression

Metformin results in decreased expression of XPC mRNA
Metformin results in increased expression of XPC mRNA

PMID:25596134 PMID:31324951

NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010

G

X-ray repair cross complementing 1

decreases activity
multiple interactions

Metformin results in decreased activity of XRCC1 protein
[Metformin co-treated with Hydrogen Peroxide] results in decreased activity of XRCC1 protein

NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701

G

tyrosyl-tRNA synthetase 1

increases expression

Metformin results in increased expression of YARS1 mRNA

NCBI chr 5:141,535,815...141,564,029
Ensembl chr 5:141,535,759...141,563,833

G

yippee-like 2

decreases expression

Metformin results in decreased expression of YPEL2 mRNA

NCBI chr10:71,746,308...71,803,843
Ensembl chr10:71,746,311...71,803,911

G

zinc finger and BTB domain containing 16

increases expression

Metformin results in increased expression of ZBTB16 mRNA

NCBI chr 8:48,989,376...49,177,011
Ensembl chr 8:48,994,566...49,177,011

G

zinc finger and BTB domain containing 21

multiple interactions

Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of ZBTB21 mRNA]

NCBI chr11:37,312,337...37,327,040
Ensembl chr11:37,312,378...37,326,996

G

zinc finger protein 239

increases expression

Metformin results in increased expression of ZFP239 mRNA

NCBI chr 4:151,029,431...151,039,283
Ensembl chr 4:151,029,405...151,039,529

G

zinc finger protein 354A

increases expression

Metformin results in increased expression of ZFP354A mRNA

NCBI chr10:35,396,242...35,408,069
Ensembl chr10:35,396,231...35,408,068

G

zinc finger protein 36

decreases expression

Metformin results in decreased expression of ZFP36 mRNA

NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564

G

zinc finger protein 46

increases expression

Metformin results in increased expression of ZFP46 mRNA

NCBI chr 5:148,519,398...148,529,903
Ensembl chr 5:148,520,855...148,529,459

G

zinc finger protein 57

multiple interactions

Metformin inhibits the reaction [Dietary Fats results in increased expression of ZFP57 protein]

NCBI chr20:1,521,323...1,534,884
Ensembl chr20:1,521,323...1,529,846

G

zinc finger protein 791

decreases expression

Metformin results in decreased expression of ZFP791 mRNA

NCBI chr19:23,018,418...23,033,580
Ensembl chr19:23,018,918...23,033,504

phenformin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

decreases expression

Phenformin results in decreased expression of A2M mRNA

NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786

G

ATP binding cassette subfamily B member 4

increases expression

Phenformin results in increased expression of ABCB4 mRNA

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

ATP binding cassette subfamily C member 3

increases expression

Phenformin results in increased expression of ABCC3 mRNA

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily D member 2

increases expression

Phenformin results in increased expression of ABCD2 mRNA

NCBI chr 7:122,263,034...122,311,642
Ensembl chr 7:122,263,032...122,311,642

G

ATP binding cassette subfamily G member 2

decreases expression

Phenformin results in decreased expression of ABCG2 mRNA

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

ATP binding cassette subfamily G member 5

increases expression

Phenformin results in increased expression of ABCG5 mRNA

NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563

G

ATP binding cassette subfamily G member 8

increases expression

Phenformin results in increased expression of ABCG8 mRNA

NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912

G

actin-binding Rho activating protein

decreases expression

Phenformin results in decreased expression of ABRA mRNA

NCBI chr 7:72,970,187...72,974,255
Ensembl chr 7:72,970,186...72,974,255

G

acetyl-CoA carboxylase alpha

decreases expression

Phenformin results in decreased expression of ACACA mRNA

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

G

atypical chemokine receptor 3

decreases expression

Phenformin results in decreased expression of ACKR3 mRNA

NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237

G

ATP citrate lyase

decreases expression

Phenformin results in decreased expression of ACLY mRNA

NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320

G

aminocarboxymuconate semialdehyde decarboxylase

increases expression

Phenformin results in increased expression of ACMSD mRNA

NCBI chr13:39,200,412...39,245,954
Ensembl chr13:39,200,314...39,245,209

G

acyl-CoA synthetase long-chain family member 3

decreases expression

Phenformin results in decreased expression of ACSL3 mRNA

NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627

G

actin, gamma 1

decreases expression

Phenformin results in decreased expression of ACTG1 mRNA

NCBI chr10:105,619,738...105,622,587
Ensembl chr10:105,619,737...105,624,232
Ensembl chr 3:105,619,737...105,624,232

G

ADAM metallopeptidase with thrombospondin type 1 motif, 1

decreases expression

Phenformin results in decreased expression of ADAMTS1 mRNA

NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103

G

alcohol dehydrogenase 4 (class II), pi polypeptide

increases expression

Phenformin results in increased expression of ADH4 mRNA

NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591

G

alcohol dehydrogenase 6 (class V)

increases expression

Phenformin results in increased expression of ADH6 mRNA

NCBI chr 2:226,903,208...226,934,564
Ensembl chr 2:226,903,250...226,934,534

G

arylformamidase

decreases expression

Phenformin results in decreased expression of AFMID mRNA

NCBI chr10:103,046,129...103,061,718
Ensembl chr10:103,046,180...103,061,718

G

alanine--glyoxylate aminotransferase

increases expression

Phenformin results in increased expression of AGXT mRNA

NCBI chr 9:93,675,384...93,685,337
Ensembl chr 9:93,675,384...93,685,336

G

aldo-keto reductase family 1, member B8, pseudogene 2

decreases expression

Phenformin results in decreased expression of AKR1B8-PS2 mRNA

NCBI chr 6:77,569,720...77,571,967

G

AKT serine/threonine kinase 1

increases phosphorylation

Phenformin results in increased phosphorylation of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

5'-aminolevulinate synthase 2

decreases expression

Phenformin results in decreased expression of ALAS2 mRNA

NCBI chr X:19,463,146...19,486,526
Ensembl chr X:19,463,171...19,486,519

G

aldehyde dehydrogenase 1 family, member A1

increases expression

Phenformin results in increased expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

arachidonate 15-lipoxygenase

decreases expression

Phenformin results in decreased expression of ALOX15 mRNA

NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874

G

alpha-methylacyl-CoA racemase

increases expression

Phenformin results in increased expression of AMACR mRNA

NCBI chr 2:59,946,158...59,958,255
Ensembl chr 2:59,946,153...59,958,255

G

amidohydrolase domain containing 1

increases expression

Phenformin results in increased expression of AMDHD1 mRNA

NCBI chr 7:28,043,923...28,059,156
Ensembl chr 7:28,043,716...28,059,156

G

angiopoietin-like 4

affects expression

Phenformin affects the expression of ANGPTL4 mRNA

NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519

G

angiopoietin-like 8

decreases expression

Phenformin results in decreased expression of ANGPTL8 mRNA

NCBI chr 8:20,376,462...20,378,488
Ensembl chr 8:20,376,462...20,378,490

G

ANKH inorganic pyrophosphate transport regulator

decreases expression

Phenformin results in decreased expression of ANKH mRNA

NCBI chr 2:78,153,027...78,280,181
Ensembl chr 2:78,153,026...78,280,187

G

anillin, actin binding protein-like 1

decreases expression

Phenformin results in decreased expression of ANLNL1 mRNA

NCBI chr17:57,985,340...57,995,824
Ensembl chr17:57,986,511...57,989,997

G

anoctamin 5

decreases expression

Phenformin results in decreased expression of ANO5 mRNA

NCBI chr 1:101,086,490...101,187,547
Ensembl chr 1:101,087,341...101,187,555

G

APC down-regulated 1

increases expression

Phenformin results in increased expression of APCDD1 mRNA

NCBI chr18:56,385,398...56,416,065
Ensembl chr18:56,385,264...56,416,070

G

aph-1 homolog B, gamma secretase subunit

decreases expression

Phenformin results in decreased expression of APH1B mRNA

NCBI chr 8:67,429,198...67,454,735
Ensembl chr 8:67,429,198...67,450,243

G

apelin receptor

increases expression

Phenformin results in increased expression of APLNR mRNA

NCBI chr 3:70,217,407...70,221,052
Ensembl chr 3:70,217,385...70,221,050

G

apolipoprotein A4

decreases expression

Phenformin results in decreased expression of APOA4 mRNA

NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469

G

apolipoprotein C4

increases expression

Phenformin results in increased expression of APOC4 mRNA

NCBI chr 1:79,335,745...79,339,942
Ensembl chr 1:79,335,745...79,339,981

G

apolipoprotein F

increases expression

Phenformin results in increased expression of APOF mRNA

NCBI chr 7:700,688...702,130
Ensembl chr 7:700,762...701,946

G

apolipoprotein L domain containing 1

decreases expression

Phenformin results in decreased expression of APOLD1 mRNA

NCBI chr 4:167,768,437...167,825,706
Ensembl chr 4:167,818,271...167,825,706

G

aquaporin 7

increases expression

Phenformin results in increased expression of AQP7 mRNA

NCBI chr 5:56,171,649...56,186,642
Ensembl chr 5:56,172,519...56,186,642

G

aquaporin 9

increases expression

Phenformin results in increased expression of AQP9 mRNA

NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395

G

androgen receptor

decreases expression

Phenformin results in decreased expression of AR mRNA

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

Rho GTPase activating protein 11A

decreases expression

Phenformin results in decreased expression of ARHGAP11A mRNA

NCBI chr 3:100,590,865...100,607,146
Ensembl chr 3:100,590,865...100,607,559

G

arrestin domain containing 4

increases expression

Phenformin results in increased expression of ARRDC4 mRNA

NCBI chr 1:122,369,355...122,383,351
Ensembl chr 1:122,369,360...122,383,290

G

argininosuccinate lyase

increases expression

Phenformin results in increased expression of ASL mRNA

NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662

G

assembly factor for spindle microtubules

decreases expression

Phenformin results in decreased expression of ASPM mRNA

NCBI chr13:51,074,849...51,123,755
Ensembl chr13:51,074,849...51,123,755

G

asporin

decreases expression

Phenformin results in decreased expression of ASPN mRNA

NCBI chr17:15,079,910...15,104,369
Ensembl chr17:15,080,639...15,104,041

G

activating transcription factor 3

decreases expression

Phenformin results in decreased expression of ATF3 mRNA

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

aurora kinase B

decreases expression

Phenformin results in decreased expression of AURKB mRNA

NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837

G

brain expressed X-linked 2

increases expression

Phenformin results in increased expression of BEX1 mRNA

NCBI chr X:99,019,847...99,021,375
Ensembl chr X:99,019,000...99,021,503

G

basic helix-loop-helix family, member e40

decreases expression

Phenformin results in decreased expression of BHLHE40 mRNA

NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774

G

BTG anti-proliferation factor 2

decreases expression

Phenformin results in decreased expression of BTG2 mRNA

NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628

G

BUB1 mitotic checkpoint serine/threonine kinase

decreases expression

Phenformin results in decreased expression of BUB1 mRNA

NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650

G

similar to human chromosome 11 open reading frame 54

decreases expression

Phenformin results in decreased expression of C8H11ORF54 mRNA

NCBI chr 8:12,123,839...12,146,412
Ensembl chr 8:12,123,823...12,146,473

G

carbonic anhydrase 5A

increases expression

Phenformin results in increased expression of CAR5A mRNA

NCBI chr19:49,973,092...50,002,948
Ensembl chr19:49,973,107...50,002,906

G

carbonic anhydrase 5B

decreases expression

Phenformin results in decreased expression of CAR5B mRNA

NCBI chr X:30,474,697...30,534,797
Ensembl chr X:30,474,784...30,533,837

G

coiled-coil domain containing 141

decreases expression

Phenformin results in decreased expression of CCDC141 mRNA

NCBI chr 3:61,948,614...62,109,968
Ensembl chr 3:61,948,646...62,110,079

G

coiled-coil domain containing 38

increases expression

Phenformin results in increased expression of CCDC38 mRNA

NCBI chr 7:28,055,883...28,129,938
Ensembl chr 7:28,059,798...28,130,441

G

coiled-coil domain containing 77

increases expression

Phenformin results in increased expression of CCDC77 mRNA

NCBI chr 4:153,534,184...153,566,059
Ensembl chr 4:153,534,187...153,566,545

G

C-C motif chemokine ligand 2

decreases expression

Phenformin results in decreased expression of CCL2 mRNA

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cellular communication network factor 2

decreases expression

Phenformin results in decreased expression of CCN2 mRNA

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

cyclin A2

decreases expression

Phenformin results in decreased expression of CCNA2 mRNA

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin B1

decreases expression

Phenformin results in decreased expression of CCNB1 mRNA

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin B2

affects expression

Phenformin affects the expression of CCNB2 mRNA

NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874

G

cyclin D1

increases expression

Phenformin results in increased expression of CCND1 mRNA

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin E2

decreases expression

Phenformin results in decreased expression of CCNE2 mRNA

NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632

G

CD226 molecule

decreases expression

Phenformin results in decreased expression of CD226 mRNA

NCBI chr18:82,449,924...82,545,107
Ensembl chr18:82,450,568...82,543,051

G

CD274 molecule

increases expression

Phenformin results in increased expression of CD274 mRNA

NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450

G

Cd5 molecule-like

increases expression

Phenformin results in increased expression of CD5L mRNA

NCBI chr 2:172,791,007...172,802,018
Ensembl chr 2:172,790,934...172,829,753

G

Cd63 molecule

increases expression

Phenformin results in increased expression of CD63 mRNA

NCBI chr 7:1,325,108...1,340,447
Ensembl chr 7:1,325,103...1,399,178

G

CD74 molecule

increases expression

Phenformin results in increased expression of CD74 mRNA

NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003

G

cell division cycle 20

decreases expression

Phenformin results in decreased expression of CDC20 mRNA

NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512

G

cyclin-dependent kinase 1

decreases expression

Phenformin results in decreased expression of CDK1 mRNA

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin-dependent kinase inhibitor 1A

increases expression
decreases expression

Phenformin results in increased expression of CDKN1A protein
Phenformin results in decreased expression of CDKN1A mRNA

PMID:14623034 PMID:31324951

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 3

decreases expression

Phenformin results in decreased expression of CDKN3 mRNA

NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945

G

cell migration inducing hyaluronidase 2

decreases expression

Phenformin results in decreased expression of CEMIP2 mRNA

NCBI chr 1:219,330,295...219,407,760
Ensembl chr 1:219,337,985...219,407,760

G

centromere protein E

decreases expression

Phenformin results in decreased expression of CENPE mRNA

NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669

G

centromere protein F

decreases expression

Phenformin results in decreased expression of CENPF mRNA

NCBI chr13:101,184,127...101,229,714
Ensembl chr13:101,184,127...101,229,669

G

carboxylesterase 2C

increases expression

Phenformin results in increased expression of CES2C mRNA

NCBI chr 1:260,391,190...260,398,757
Ensembl chr 1:260,388,902...260,398,790

G

carboxylesterase 4A

decreases expression

Phenformin results in decreased expression of CES4A mRNA

NCBI chr19:33,011,731...33,030,119
Ensembl chr19:33,011,731...33,029,545

G

choline kinase alpha

decreases expression

Phenformin results in decreased expression of CHKA mRNA

NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516

G

cytokine inducible SH2-containing protein

decreases expression

Phenformin results in decreased expression of CISH mRNA

NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250

G

cytoskeleton associated protein 2

decreases expression

Phenformin results in decreased expression of CKAP2 mRNA

NCBI chr16:69,839,668...69,864,852
Ensembl chr16:69,839,630...69,864,913

G

CDC28 protein kinase regulatory subunit 2

decreases expression

Phenformin results in decreased expression of CKS2 mRNA

NCBI chr17:13,570,611...13,575,770

G

C-type lectin domain family 1, member A

decreases expression

Phenformin results in decreased expression of CLEC1A mRNA

NCBI chr 4:162,875,360...162,902,571
Ensembl chr 4:162,877,346...162,901,247

G

C-type lectin domain family 1, member B

decreases expression

Phenformin results in decreased expression of CLEC1B mRNA

NCBI chr 4:162,847,978...162,856,291
Ensembl chr 4:162,848,010...162,856,291

G

copine 8

increases expression

Phenformin results in increased expression of CPNE8 mRNA

NCBI chr 7:121,615,293...121,789,507
Ensembl chr 7:121,615,294...121,790,377

G

carnitine palmitoyltransferase 1A

increases expression

Phenformin results in increased expression of CPT1A mRNA

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

carnitine O-acetyltransferase

increases expression

Phenformin results in increased expression of CRAT mRNA

NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255

G

carnitine O-octanoyltransferase

increases expression

Phenformin results in increased expression of CROT mRNA

NCBI chr 4:25,068,270...25,133,111
Ensembl chr 4:25,080,587...25,133,109

G

cryptochrome circadian regulator 1

decreases expression

Phenformin results in decreased expression of CRY1 mRNA

NCBI chr 7:18,529,823...18,594,092
Ensembl chr 7:18,529,823...18,594,091

G

crystallin, lambda 1

increases expression

Phenformin results in increased expression of CRYL1 mRNA

NCBI chr15:31,427,011...31,545,997
Ensembl chr15:31,427,054...31,545,997

G

cysteine sulfinic acid decarboxylase

decreases expression

Phenformin results in decreased expression of CSAD mRNA

NCBI chr 7:133,308,571...133,337,914
Ensembl chr 7:133,308,574...133,337,615

G

cysteine and glycine-rich protein 1

decreases expression

Phenformin results in decreased expression of CSRP1 mRNA

NCBI chr13:47,158,171...47,179,388
Ensembl chr13:47,167,789...47,179,384

G

C-X-C motif chemokine ligand 1

decreases expression

Phenformin results in decreased expression of CXCL1 mRNA

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 10

decreases expression

Phenformin results in decreased expression of CXCL10 mRNA

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine receptor 4

increases expression

Phenformin results in increased expression of CXCR4 mRNA

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases expression

Phenformin results in decreased expression of CYP17A1 mRNA

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 2, subfamily b, polypeptide 1

increases expression

Phenformin results in increased expression of CYP2B1 mRNA

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily c, polypeptide 12

decreases expression

Phenformin results in decreased expression of CYP2C12 mRNA

NCBI chr 1:238,699,859...238,757,011
Ensembl chr 1:238,699,854...238,757,019

G

cytochrome P450, family 2, subfamily c, polypeptide 24

increases expression

Phenformin results in increased expression of CYP2C24 mRNA

NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases expression

Phenformin results in increased expression of CYP2E1 mRNA

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 18

increases expression

Phenformin results in increased expression of CYP3A18 mRNA

NCBI chr12:8,880,509...8,930,382
Ensembl chr12:8,880,528...8,930,381

G

cytochrome P450, family 4, subfamily a, polypeptide 1

increases expression

Phenformin results in increased expression of CYP4A1 mRNA

NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464

G

cytochrome P450, family 4, subfamily a, polypeptide 2

increases expression

Phenformin results in increased expression of CYP4A2 mRNA

NCBI chr 5:128,922,355...128,934,188
Ensembl chr 5:128,923,615...128,934,165

G

cytochrome P450 family 7 subfamily A member 1

decreases expression

Phenformin results in decreased expression of CYP7A1 mRNA

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

cytochrome P450 family 8 subfamily B member 1

increases expression

Phenformin results in increased expression of CYP8B1 mRNA

NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166

G

D-box binding PAR bZIP transcription factor

increases expression

Phenformin results in increased expression of DBP mRNA

NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745

G

decorin

decreases expression

Phenformin results in decreased expression of DCN mRNA

NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270

G

DDHD domain containing 1

increases expression

Phenformin results in increased expression of DDHD1 mRNA

NCBI chr15:18,824,389...18,891,036
Ensembl chr15:18,824,394...18,890,952

G

DNA-damage-inducible transcript 4

decreases expression

Phenformin results in decreased expression of DDIT4 mRNA

NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105

G

2,4-dienoyl-CoA reductase 1

increases expression

Phenformin results in increased expression of DECR1 mRNA

NCBI chr 5:29,411,172...29,439,054
Ensembl chr 5:29,411,172...29,439,018

G

DEP domain containing 1

decreases expression

Phenformin results in decreased expression of DEPDC1 mRNA

NCBI chr 2:248,684,508...248,717,951
Ensembl chr 2:248,684,523...248,717,951

G

diaphanous-related formin 3

decreases expression

Phenformin results in decreased expression of DIAPH3 mRNA

NCBI chr15:62,543,375...63,013,060
Ensembl chr15:62,543,375...63,012,975

G

iodothyronine deiodinase 1

decreases expression

Phenformin results in decreased expression of DIO1 mRNA

NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970

G

deleted in malignant brain tumors 1

increases expression

Phenformin results in increased expression of DMBT1 mRNA

NCBI chr 1:185,617,469...185,696,476
Ensembl chr 1:185,617,294...185,696,478

G

Dmx-like 2

decreases expression

Phenformin results in decreased expression of DMXL2 mRNA

NCBI chr 8:54,741,164...54,884,948
Ensembl chr 8:54,741,160...54,885,161

G

dual specificity phosphatase 1

decreases expression

Phenformin results in decreased expression of DUSP1 mRNA

NCBI chr10:16,680,478...16,683,275

G

enoyl-CoA hydratase 1

increases expression

Phenformin results in increased expression of ECH1 mRNA

NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795

G

enoyl-CoA delta isomerase 1

increases expression

Phenformin results in increased expression of ECI1 mRNA

NCBI chr10:13,456,715...13,470,061
Ensembl chr10:13,456,563...13,470,061

G

epithelial cell transforming 2

decreases expression

Phenformin results in decreased expression of ECT2 mRNA

NCBI chr 2:109,975,813...110,037,911
Ensembl chr 2:109,975,813...110,037,911

G

ER degradation enhancing alpha-mannosidase like protein 1

decreases expression

Phenformin results in decreased expression of EDEM1 mRNA

NCBI chr 4:141,797,631...141,829,717
Ensembl chr 4:141,797,701...141,829,717

G

EGF like repeats and discoidin domains 3

decreases expression

Phenformin results in decreased expression of EDIL3 mRNA

NCBI chr 2:19,890,396...20,405,028
Ensembl chr 2:19,890,373...20,405,008

G

early growth response 1

decreases expression

Phenformin results in decreased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

elongation factor for RNA polymerase II 2

decreases expression

Phenformin results in decreased expression of ELL2 mRNA

NCBI chr 2:5,189,375...5,258,781
Ensembl chr 2:5,189,971...5,258,781

G

ELOVL fatty acid elongase 2

increases expression

Phenformin results in increased expression of ELOVL2 mRNA

NCBI chr17:23,544,598...23,584,855
Ensembl chr17:23,544,568...23,584,848

G

ELOVL fatty acid elongase 6

decreases expression

Phenformin results in decreased expression of ELOVL6 mRNA

NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186

G

glutamate-rich 5

decreases expression

Phenformin results in decreased expression of ERICH5 mRNA

NCBI chr 7:65,655,829...65,682,221
Ensembl chr 7:65,657,204...65,680,207

G

ERBB receptor feedback inhibitor 1

decreases expression

Phenformin results in decreased expression of ERRFI1 mRNA

NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282

G

establishment of sister chromatid cohesion N-acetyltransferase 2

decreases expression

Phenformin results in decreased expression of ESCO2 mRNA

NCBI chr15:40,034,566...40,052,295
Ensembl chr15:40,034,568...40,055,306

G

endothelial cell-specific molecule 1

increases expression

Phenformin results in increased expression of ESM1 mRNA

NCBI chr 2:44,876,067...44,884,805
Ensembl chr 2:44,876,067...44,884,804

G

coagulation factor II (thrombin) receptor-like 2

decreases expression

Phenformin results in decreased expression of F2RL2 mRNA

NCBI chr 2:26,972,054...26,977,098
Ensembl chr 2:26,972,054...26,977,098

G

coagulation factor III, tissue factor

decreases expression

Phenformin results in decreased expression of F3 mRNA

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

fatty acid binding protein 5

decreases expression

Phenformin results in decreased expression of FABP5 mRNA

NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773

G

FAM111 trypsin like peptidase A

decreases expression

Phenformin results in decreased expression of FAM111A mRNA

NCBI chr 1:209,640,865...209,656,551
Ensembl chr 1:209,640,953...209,656,547

G

family with sequence similarity 117, member B

increases expression

Phenformin results in increased expression of FAM117B mRNA

NCBI chr 9:61,340,284...61,418,531
Ensembl chr 9:61,340,249...61,408,483

G

family with sequence similarity 149, member A

decreases expression

Phenformin results in decreased expression of FAM149A mRNA

NCBI chr16:46,855,377...46,914,553
Ensembl chr16:46,854,635...46,912,066

G

family with sequence similarity 83, member D

decreases expression

Phenformin results in decreased expression of FAM83D mRNA

NCBI chr 3:147,421,941...147,441,211
Ensembl chr 3:147,421,908...147,441,192

G

fatty acid synthase

decreases expression

Phenformin results in decreased expression of FASN mRNA

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

flavin containing dimethylaniline monoxygenase 2

decreases expression

Phenformin results in decreased expression of FMO2 mRNA

NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308

G

flavin containing dimethylaniline monoxygenase 5

increases expression

Phenformin results in increased expression of FMO5 mRNA

NCBI chr 2:185,197,184...185,249,699
Ensembl chr 2:185,222,204...185,249,693

G

Fos proto-oncogene, AP-1 transcription factor subunit

decreases expression

Phenformin results in decreased expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box A1

decreases expression

Phenformin results in decreased expression of FOXA1 mRNA

NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188

G

forkhead box A2

decreases expression

Phenformin results in decreased expression of FOXA2 mRNA

NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326

G

forkhead box O3

decreases expression

Phenformin results in decreased expression of FOXO3 mRNA

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

formyl peptide receptor 1

decreases expression

Phenformin results in decreased expression of FPR1 mRNA

NCBI chr 1:58,745,019...58,756,776
Ensembl chr 1:58,747,246...58,756,559

G

Fraser extracellular matrix complex subunit 1

decreases expression

Phenformin results in decreased expression of FRAS1 mRNA

NCBI chr14:12,791,407...13,200,862
Ensembl chr14:12,793,599...13,200,726

G

glucose-6-phosphatase catalytic subunit 1

decreases expression

Phenformin results in decreased expression of G6PC1 mRNA

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

growth arrest and DNA-damage-inducible, gamma

decreases expression

Phenformin results in decreased expression of GADD45G mRNA

NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610

G

1,4-alpha-glucan branching enzyme 1

decreases expression

Phenformin results in decreased expression of GBE1 mRNA

NCBI chr11:8,734,806...9,000,226
Ensembl chr11:8,734,820...9,000,210

G

guanylate binding protein 1

increases expression

Phenformin results in increased expression of GBP1 mRNA

NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131
Ensembl chr 2:231,398,163...231,432,131

G

guanylate binding protein 1, pseudogene 1

increases expression

Phenformin results in increased expression of GBP1-PS1 mRNA

NCBI chr 2:231,517,485...231,525,865
Ensembl chr 2:231,517,398...231,529,600

G

glucokinase

decreases expression

Phenformin results in decreased expression of GCK mRNA

NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995

G

GIMAP family P-loop NTPase domain containing 1

decreases expression

Phenformin results in decreased expression of GIMD1 mRNA

NCBI chr 2:221,103,878...221,138,559
Ensembl chr 2:221,103,878...221,138,553

G

glycerol kinase

increases expression

Phenformin results in increased expression of GK mRNA

NCBI chr X:50,162,089...50,238,707
Ensembl chr X:50,163,123...50,238,631

G

glycine N-methyltransferase

increases expression

Phenformin results in increased expression of GNMT mRNA

NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434

G

glutamic-oxaloacetic transaminase 1

increases expression

Phenformin results in increased expression of GOT1 mRNA

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glycoprotein V (platelet)

decreases expression

Phenformin results in decreased expression of GP5 mRNA

NCBI chr11:70,443,613...70,446,705
Ensembl chr11:70,443,613...70,446,705

G

glycoprotein A33

increases expression

Phenformin results in increased expression of GPA33 mRNA

NCBI chr13:78,381,141...78,414,765
Ensembl chr13:78,381,141...78,414,765

G

glycerol-3-phosphate acyltransferase, mitochondrial

increases expression

Phenformin results in increased expression of GPAM mRNA

NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639

G

glycerol-3-phosphate acyltransferase 3

increases expression

Phenformin results in increased expression of GPAT3 mRNA

NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490

G

glycerol-3-phosphate dehydrogenase 2

increases expression

Phenformin results in increased expression of GPD2 mRNA

NCBI chr 3:41,800,552...41,937,729
Ensembl chr 3:41,801,930...41,936,901

G

glycoprotein nmb

increases expression

Phenformin results in increased expression of GPNMB mRNA

NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367

G

GPRIN family member 3

decreases expression

Phenformin results in decreased expression of GPRIN3 mRNA

NCBI chr 4:88,572,062...88,657,369
Ensembl chr 4:88,563,607...88,657,429

G

glutamic--pyruvic transaminase

increases expression

Phenformin results in increased expression of GPT mRNA

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 2, pseudogene 2

affects expression

Phenformin affects the expression of GPX2-PS2 mRNA

NCBI chr X:59,444,660...59,445,203

G

glutathione S-transferase mu 2

increases expression

Phenformin results in increased expression of GSTM2 mRNA

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase mu 4

increases expression

Phenformin results in increased expression of GSTM4 mRNA

NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323

G

glutathione S-transferase zeta 1

increases expression

Phenformin results in increased expression of GSTZ1 mRNA

NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284

G

glycophorin A

decreases expression

Phenformin results in decreased expression of GYPA mRNA

NCBI chr19:27,450,304...27,465,940
Ensembl chr19:27,450,308...27,465,822

G

H2A clustered histone 4

decreases expression

Phenformin results in decreased expression of H2AC4 mRNA

NCBI chr17:42,799,884...42,800,387
Ensembl chr17:42,799,652...42,800,381

G

H2A.X variant histone

decreases expression

Phenformin results in decreased expression of H2AX mRNA

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

G

hepcidin antimicrobial peptide

decreases expression

Phenformin results in decreased expression of HAMP mRNA

NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891

G

hemoglobin subunit beta

decreases expression

Phenformin results in decreased expression of HBB-B1 mRNA

NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012

G

hematopoietically expressed homeobox

decreases expression

Phenformin results in decreased expression of HHEX mRNA

NCBI chr 1:235,190,455...235,196,042
Ensembl chr 1:235,190,455...235,196,042

G

hypoxia inducible factor 1 subunit alpha

increases expression

Phenformin results in increased expression of HIF1A protein

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

histone cluster 1 H2A family member F

decreases expression

Phenformin results in decreased expression of HIST1H2AF mRNA

NCBI chr17:41,379,404...41,379,796
Ensembl chr17:41,379,404...41,379,796

G

histone cluster 1 H2a family member I like 1

decreases expression

Phenformin results in decreased expression of HIST1H2AIL1 mRNA

NCBI chr17:41,568,181...41,569,093
Ensembl chr17:41,568,471...41,569,109

G

histone cluster 2 H3 family member C2

decreases expression

Phenformin results in decreased expression of HIST2H3C2 mRNA

NCBI chr 2:183,837,296...183,837,721
Ensembl chr 2:183,837,303...183,837,752

G

HLF transcription factor, PAR bZIP family member

decreases expression

Phenformin results in decreased expression of HLF mRNA

NCBI chr10:75,154,244...75,211,884
Ensembl chr10:75,154,507...75,211,935

G

3-hydroxy-3-methylglutaryl-CoA reductase

decreases expression

Phenformin results in decreased expression of HMGCR mRNA

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

hyaluronan-mediated motility receptor

decreases expression

Phenformin results in decreased expression of HMMR mRNA

NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060

G

hydroxysteroid (17-beta) dehydrogenase 2

increases expression

Phenformin results in increased expression of HSD17B2 mRNA

NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202

G

heat shock protein 90 alpha family class A member 1

decreases expression

Phenformin results in decreased expression of HSP90AA1 mRNA

NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268

G

heat shock protein family A (Hsp70) member 4 like

decreases expression

Phenformin results in decreased expression of HSPA4L mRNA

NCBI chr 2:123,740,384...123,793,088
Ensembl chr 2:123,740,384...123,793,084

G

hydroxylysine kinase

increases expression

Phenformin results in increased expression of HYKK mRNA

NCBI chr 8:55,315,919...55,339,720
Ensembl chr 8:55,315,969...55,337,339

G

immediate early response 2

decreases expression

Phenformin results in decreased expression of IER2 mRNA

NCBI chr19:23,494,551...23,496,075
Ensembl chr19:23,494,184...23,499,211

G

interferon-gamma-inducible GTPase 4 like

increases expression

Phenformin results in increased expression of IFGGA4L mRNA

NCBI chr18:53,838,426...53,854,858
Ensembl chr18:53,851,449...53,852,696

G

interferon induced transmembrane protein 3

increases expression

Phenformin results in increased expression of IFITM3 mRNA

NCBI chr 1:196,111,026...196,112,135
Ensembl chr 1:196,111,043...196,112,203

G

insulin-like growth factor 2 mRNA binding protein 3

decreases expression

Phenformin results in decreased expression of IGF2BP3 mRNA

NCBI chr 4:78,060,494...78,195,007
Ensembl chr 4:78,060,494...78,194,865

G

insulin-like growth factor binding protein, acid labile subunit

decreases expression

Phenformin results in decreased expression of IGFALS mRNA

NCBI chr10:13,897,468...13,903,920
Ensembl chr10:13,898,395...13,902,677

G

insulin-like growth factor binding protein 2

increases expression

Phenformin results in increased expression of IGFBP2 mRNA

NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937

G

insulin-like growth factor binding protein 5

decreases expression

Phenformin results in decreased expression of IGFBP5 mRNA

NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156

G

interleukin 1 receptor type 1

increases expression

Phenformin results in increased expression of IL1R1 mRNA

NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937

G

interleukin 33

increases expression

Phenformin results in increased expression of IL33 mRNA

NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373

G

inhibin subunit alpha

decreases expression

Phenformin results in decreased expression of INHA mRNA

NCBI chr 9:76,994,465...76,997,366
Ensembl chr 9:76,993,589...76,997,248

G

inhibin subunit beta A

decreases expression

Phenformin results in decreased expression of INHBA mRNA

NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982

G

inhibin subunit beta E

increases expression

Phenformin results in increased expression of INHBE mRNA

NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172

G

indolethylamine N-methyltransferase

increases expression

Phenformin results in increased expression of INMT mRNA

NCBI chr 4:84,318,197...84,322,493
Ensembl chr 4:84,318,197...84,322,493

G

insulin induced gene 1

decreases expression

Phenformin results in decreased expression of INSIG1 mRNA

NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952

G

insulin induced gene 2

increases expression

Phenformin results in increased expression of INSIG2 mRNA

NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923

G

inositol hexakisphosphate kinase 2

decreases expression

Phenformin results in decreased expression of IP6K2 mRNA

NCBI chr 8:109,483,843...109,510,172
Ensembl chr 8:109,484,310...109,510,166

G

interferon regulatory factor 2 binding protein 2

decreases expression

Phenformin results in decreased expression of IRF2BP2 mRNA

NCBI chr19:54,559,417...54,565,096
Ensembl chr19:54,560,128...54,566,642

G

interferon regulatory factor 2 binding protein-like

decreases expression

Phenformin results in decreased expression of IRF2BPL mRNA

NCBI chr 6:106,527,179...106,531,294
Ensembl chr 6:106,528,053...106,530,401

G

insulin receptor substrate 2

decreases expression

Phenformin results in decreased expression of IRS2 mRNA

NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression

Phenformin results in decreased expression of JUN mRNA

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

JunB proto-oncogene, AP-1 transcription factor subunit

decreases expression

Phenformin results in decreased expression of JUNB mRNA

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035

G

potassium voltage-gated channel subfamily A member 2

increases expression

Phenformin results in increased expression of KCNA2 mRNA

NCBI chr 2:194,704,555...194,718,387
Ensembl chr 2:194,704,639...194,718,400

G

potassium inwardly-rectifying channel, subfamily J, member 5

increases expression

Phenformin results in increased expression of KCNJ5 mRNA

NCBI chr 8:30,724,923...30,753,083
Ensembl chr 8:30,724,925...30,753,518

G

kinesin family member 11

decreases expression

Phenformin results in decreased expression of KIF11 mRNA

NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766

G

kinesin family member 20A

decreases expression

Phenformin results in decreased expression of KIF20A mRNA

NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780

G

kinesin family member 20B

decreases expression

Phenformin results in decreased expression of KIF20B mRNA

NCBI chr 1:232,428,293...232,483,798
Ensembl chr 1:232,428,371...232,483,787

G

kinesin family member 23

decreases expression

Phenformin results in decreased expression of KIF23 mRNA

NCBI chr 8:62,397,908...62,425,162
Ensembl chr 8:62,397,948...62,425,072

G

kinetochore scaffold 1

decreases expression

Phenformin results in decreased expression of KNL1 mRNA

NCBI chr 3:106,029,627...106,091,915
Ensembl chr 3:106,029,661...106,091,915

G

keratin 18

increases expression

Phenformin results in increased expression of KRT18 mRNA

NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166

G

lipopolysaccharide binding protein

increases expression

Phenformin results in increased expression of LBP mRNA

NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586

G

leptin receptor

increases response to substance

LEPR gene mutant form results in increased susceptibility to Phenformin

NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908

G

galectin 5

decreases expression

Phenformin results in decreased expression of LGALS5 mRNA

NCBI chr10:63,853,949...63,857,198
Ensembl chr10:63,853,935...63,857,153

G

lengsin, lens protein with glutamine synthetase domain

decreases expression

Phenformin results in decreased expression of LGSN mRNA

NCBI chr 9:33,416,362...33,447,919
Ensembl chr 9:33,420,484...33,447,907

G

lipase, member O1

decreases expression

Phenformin results in decreased expression of LIPO1 mRNA

NCBI chr 1:231,311,828...231,328,805
Ensembl chr 1:231,311,315...231,325,187

G

lysyl oxidase-like 4

increases expression

Phenformin results in increased expression of LOXL4 mRNA

NCBI chr 1:241,396,183...241,416,385
Ensembl chr 1:241,397,983...241,416,322

G

lysophosphatidic acid receptor 6

increases expression

Phenformin results in increased expression of LPAR6 mRNA

NCBI chr15:48,416,548...48,418,357
Ensembl chr15:48,416,544...48,422,331

G

lipin 1

decreases expression

Phenformin results in decreased expression of LPIN1 mRNA

NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097

G

lumican

decreases expression

Phenformin results in decreased expression of LUM mRNA

NCBI chr 7:32,358,990...32,365,794
Ensembl chr 7:32,358,614...32,365,793

G

leucine rich adaptor protein 1-like

decreases expression

Phenformin results in decreased expression of LURAP1L mRNA

NCBI chr 5:95,362,005...95,409,439
Ensembl chr 5:95,362,005...95,409,438

G

Ly6-C antigen

increases expression

Phenformin results in increased expression of LY6C mRNA

NCBI chr 7:106,959,508...106,963,329
Ensembl chr 7:106,959,511...106,963,329

G

Ly6/neurotoxin 1

decreases expression

Phenformin results in decreased expression of LYNX1 mRNA

NCBI chr 7:106,632,800...106,638,003
Ensembl chr 7:106,632,797...106,638,023

G

microtubule associated serine/threonine kinase-like

decreases expression

Phenformin results in decreased expression of MASTL mRNA

NCBI chr17:85,250,512...85,287,479
Ensembl chr17:85,251,997...85,287,353

G

muscleblind-like splicing regulator 3

increases expression

Phenformin results in increased expression of MBNL3 mRNA

NCBI chr X:130,641,942...130,737,179
Ensembl chr X:130,648,538...130,737,056

G

mesoderm specific transcript

decreases expression

Phenformin results in decreased expression of MEST mRNA

NCBI chr 4:59,354,445...59,364,919
Ensembl chr 4:59,354,447...59,366,145

G

microfibril associated protein 4

decreases expression

Phenformin results in decreased expression of MFAP4 mRNA

NCBI chr10:46,167,158...46,170,176
Ensembl chr10:46,167,217...46,170,155

G

MFSD2 lysolipid transporter A, lysophospholipid

decreases expression

Phenformin results in decreased expression of MFSD2A mRNA

NCBI chr 5:135,225,801...135,240,744
Ensembl chr 5:135,225,816...135,240,690

G

alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B

decreases expression

Phenformin results in decreased expression of MGAT4B mRNA

NCBI chr10:34,548,918...34,559,229
Ensembl chr10:34,549,433...34,559,229

G

matrix Gla protein

decreases expression

Phenformin results in decreased expression of MGP mRNA

NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667

G

microRNA 15b

increases expression

Phenformin results in increased expression of MIR15B mRNA

NCBI chr 2:153,245,200...153,245,297
Ensembl chr 2:153,245,200...153,245,297

G

microRNA 29b-2

increases expression

Phenformin results in increased expression of MIR29B2 mRNA

NCBI chr13:106,570,371...106,570,451
Ensembl chr13:106,570,367...106,570,456

G

microRNA let-7c-1

increases expression

Phenformin results in increased expression of MIRLET7C-1 mRNA

NCBI chr11:16,201,163...16,201,256
Ensembl chr11:16,201,158...16,201,265

G

marker of proliferation Ki-67

decreases expression

Phenformin results in decreased expression of MKI67 mRNA

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

MAPK interacting serine/threonine kinase 2

decreases expression

Phenformin results in decreased expression of MKNK2 mRNA

NCBI chr 7:9,039,771...9,050,832
Ensembl chr 7:9,039,728...9,050,827

G

MLX interacting protein-like

decreases expression

Phenformin results in decreased expression of MLXIPL mRNA

NCBI chr12:21,541,608...21,577,120
Ensembl chr12:21,543,576...21,577,112

G

macrophage stimulating 1 receptor

decreases expression

Phenformin results in decreased expression of MST1R mRNA

NCBI chr 8:108,596,100...108,611,441
Ensembl chr 8:108,597,299...108,612,455

G

metallothionein 1

increases expression

Phenformin results in increased expression of MT1A mRNA; Phenformin results in increased expression of MT1F mRNA; Phenformin results in increased expression of MT1M mRNA

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049

G

metallothionein 2A

increases expression

Phenformin results in increased expression of MT2A mRNA

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

MTSS I-BAR domain containing 1

decreases expression

Phenformin results in decreased expression of MTSS1 mRNA

NCBI chr 7:90,488,751...90,628,007
Ensembl chr 7:90,488,754...90,627,968

G

MX dynamin like GTPase 2

increases expression

Phenformin results in increased expression of MX2 mRNA

NCBI chr11:36,905,698...36,936,308
Ensembl chr11:36,906,111...36,930,342

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

Phenformin results in decreased expression of MYC mRNA

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

myosin heavy chain 7

increases expression

Phenformin results in increased expression of MYH7 mRNA

NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217

G

myocilin

increases expression

Phenformin results in increased expression of MYOC mRNA

NCBI chr13:74,976,730...74,987,128
Ensembl chr13:74,976,730...74,987,127

G

myomesin 2

increases expression

Phenformin results in increased expression of MYOM2 mRNA

NCBI chr16:74,520,148...74,592,658
Ensembl chr16:74,520,157...74,592,772

G

non-SMC condensin I complex, subunit G

decreases expression

Phenformin results in decreased expression of NCAPG mRNA

NCBI chr14:65,403,930...65,432,902
Ensembl chr14:65,404,163...65,432,902

G

neutrophil cytosolic factor 1

increases expression

Phenformin results in increased expression of NCF1 mRNA

NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646

G

NDC80 kinetochore complex component

decreases expression

Phenformin results in decreased expression of NDC80 mRNA

NCBI chr 9:111,407,191...111,440,921
Ensembl chr 9:111,407,191...111,440,924

G

NFE2 like bZIP transcription factor 2

increases activity

Phenformin results in increased activity of NFE2L2 protein

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFKB inhibitor alpha

decreases expression

Phenformin results in decreased expression of NFKBIA mRNA

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

neuronal guanine nucleotide exchange factor

decreases expression

Phenformin results in decreased expression of NGEF mRNA

NCBI chr 9:88,146,956...88,244,454
Ensembl chr 9:88,146,956...88,244,914

G

nocturnin

decreases expression

Phenformin results in decreased expression of NOCT mRNA

NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:135,271,189...135,291,400

G

natriuretic peptide A

increases expression

Phenformin results in increased expression of NPPA mRNA

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

natriuretic peptide receptor 3

increases expression

Phenformin results in increased expression of NPR3 mRNA

NCBI chr 2:60,865,483...60,933,432
Ensembl chr 2:60,870,594...60,932,955

G

neuropeptide Y

affects expression

Phenformin affects the expression of NPY mRNA

NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495

G

NAD(P)H quinone dehydrogenase 1

increases expression

Phenformin results in increased expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 1, group D, member 1

increases expression

Phenformin results in increased expression of NR1D1 mRNA

NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705

G

nuclear receptor subfamily 1, group D, member 2

increases expression

Phenformin results in increased expression of NR1D2 mRNA

NCBI chr15:7,524,257...7,550,553
Ensembl chr15:7,524,257...7,550,553

G

nuclear receptor subfamily 4, group A, member 1

decreases expression

Phenformin results in decreased expression of NR4A1 mRNA

NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297

G

nuclear receptor subfamily 4, group A, member 2

decreases expression

Phenformin results in decreased expression of NR4A2 mRNA

NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877

G

nuclear receptor subfamily 4, group A, member 3

decreases expression

Phenformin results in decreased expression of NR4A3 mRNA

NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733

G

NUF2 component of NDC80 kinetochore complex

decreases expression

Phenformin results in decreased expression of NUF2 mRNA

NCBI chr13:81,693,675...81,722,765
Ensembl chr13:81,693,598...81,722,766

G

nucleolar and spindle associated protein 1

decreases expression

Phenformin results in decreased expression of NUSAP1 mRNA

NCBI chr 3:106,603,273...106,633,428
Ensembl chr 3:106,603,289...106,633,624

G

out at first homolog

increases expression

Phenformin results in increased expression of OAF mRNA

NCBI chr 8:43,594,362...43,612,334
Ensembl chr 8:43,594,363...43,612,334

G

ornithine aminotransferase

increases expression

Phenformin results in increased expression of OAT mRNA

NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682

G

olfactory receptor 906

increases expression

Phenformin results in increased expression of OLR906 mRNA

NCBI chr 7:1,821,264...1,822,202
Ensembl chr 7:1,821,264...1,822,202

G

osteomodulin

decreases expression

Phenformin results in decreased expression of OMD mRNA

NCBI chr17:15,060,217...15,068,441
Ensembl chr17:15,060,217...15,068,441

G

opioid binding protein/cell adhesion molecule-like

decreases expression

Phenformin results in decreased expression of OPCML mRNA

NCBI chr 8:26,788,988...27,304,551
Ensembl chr 8:26,192,841...27,300,620

G

oxysterol binding protein-like 3

decreases expression

Phenformin results in decreased expression of OSBPL3 mRNA

NCBI chr 4:79,346,583...79,523,523
Ensembl chr 4:79,350,349...79,523,393

G

oxidative stress induced growth inhibitor 1

decreases expression

Phenformin results in decreased expression of OSGIN1 mRNA

NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516

G

OTU deubiquitinase 1

decreases expression

Phenformin results in decreased expression of OTUD1 mRNA

NCBI chr17:82,259,920...82,262,770
Ensembl chr17:82,259,840...82,262,995

G

purinergic receptor P2X 7

increases expression

Phenformin results in increased expression of P2RX7 mRNA

NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619

G

purinergic receptor P2Y2

increases expression

Phenformin results in increased expression of P2RY2 mRNA

NCBI chr 1:155,352,050...155,367,423
Ensembl chr 1:155,351,165...155,367,632

G

progestin and adipoQ receptor family member 9

decreases expression

Phenformin results in decreased expression of PAQR9 mRNA

NCBI chr 8:96,114,249...96,116,546

G

PDZ binding kinase

decreases expression

Phenformin results in decreased expression of PBK mRNA

NCBI chr15:40,022,873...40,034,014
Ensembl chr15:40,023,002...40,034,014

G

phenazine biosynthesis-like protein domain containing 1

increases expression

Phenformin results in increased expression of PBLD1 mRNA

NCBI chr20:25,551,274...25,566,543
Ensembl chr20:25,551,275...25,565,614

G

PCNA clamp associated factor

decreases expression

Phenformin results in decreased expression of PCLAF mRNA

NCBI chr 8:66,420,606...66,432,994
Ensembl chr 8:66,420,587...66,432,994
Ensembl chr 8:66,420,587...66,432,994

G

phosphodiesterase 4B

increases expression

Phenformin results in increased expression of PDE4B mRNA

NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696

G

pyruvate dehydrogenase kinase 4

increases expression

Phenformin results in increased expression of PDK4 mRNA

NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850

G

PDZ and LIM domain 1

decreases expression

Phenformin results in decreased expression of PDLIM1 mRNA

NCBI chr 1:239,042,372...239,091,074
Ensembl chr 1:239,042,385...239,091,076

G

PDZ and LIM domain 3

decreases expression

Phenformin results in decreased expression of PDLIM3 mRNA

NCBI chr16:46,352,460...46,383,680
Ensembl chr16:46,352,467...46,383,657

G

PDZ domain containing RING finger 3

increases expression

Phenformin results in increased expression of PDZRN3 mRNA

NCBI chr 4:133,770,736...133,996,959
Ensembl chr 4:133,770,736...133,996,959

G

proenkephalin

increases expression

Phenformin results in increased expression of PENK mRNA

NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129

G

period circadian regulator 1

decreases expression

Phenformin results in decreased expression of PER1 mRNA

NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431

G

period circadian regulator 2

decreases expression

Phenformin results in decreased expression of PER2 mRNA

NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459

G

peroxisomal biogenesis factor 11 alpha

increases expression

Phenformin results in increased expression of PEX11A mRNA

NCBI chr 1:133,680,091...133,687,172
Ensembl chr 1:133,680,091...133,687,172

G

peroxisomal biogenesis factor 16

increases expression

Phenformin results in increased expression of PEX16 mRNA

NCBI chr 3:78,347,212...78,352,603
Ensembl chr 3:78,343,164...78,353,207

G

platelet factor 4

decreases expression

Phenformin results in decreased expression of PF4 mRNA

NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

decreases expression

Phenformin results in decreased expression of PFKFB1 mRNA

NCBI chr X:19,508,522...19,562,165
Ensembl chr X:19,508,546...19,562,182

G

putative homeodomain transcription factor 1

decreases expression

Phenformin results in decreased expression of PHTF1 mRNA

NCBI chr 2:191,470,849...191,537,399
Ensembl chr 2:191,473,130...191,512,078

G

peptidase inhibitor 15

decreases expression

Phenformin results in decreased expression of PI15 mRNA

NCBI chr 5:1,395,094...1,423,213
Ensembl chr 5:1,395,094...1,423,213

G

phosphoinositide-3-kinase regulatory subunit 1

decreases expression

Phenformin results in decreased expression of PIK3R1 mRNA

NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631

G

pyruvate kinase L/R

decreases expression

Phenformin results in decreased expression of PKLR mRNA

NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870

G

phospholipase A2, group XIIA

increases expression

Phenformin results in increased expression of PLA2G12A mRNA

NCBI chr 2:218,436,497...218,452,742
Ensembl chr 2:218,436,513...218,452,740

G

phospholipase C, gamma 1

increases phosphorylation

Phenformin results in increased phosphorylation of PLCG1 protein

NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330

G

perilipin 2

decreases expression

Phenformin results in decreased expression of PLIN2 mRNA

NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319

G

polo-like kinase 1

decreases expression

Phenformin results in decreased expression of PLK1 mRNA

NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400

G

phospholipid phosphatase related 1

decreases expression

Phenformin results in decreased expression of PLPPR1 mRNA

NCBI chr 5:63,437,457...63,725,286
Ensembl chr 5:63,437,816...63,763,835

G

patatin-like phospholipase domain containing 3

decreases expression

Phenformin results in decreased expression of PNPLA3 mRNA

NCBI chr 7:115,293,538...115,314,077
Ensembl chr 7:115,293,538...115,314,077

G

cytochrome p450 oxidoreductase

decreases expression

Phenformin results in decreased expression of POR mRNA

NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245

G

POTE ankyrin domain family, member F

decreases expression

Phenformin results in decreased expression of POTEF mRNA

NCBI chr18:23,626,518...23,629,132
Ensembl chr 3:72,977,767...72,979,694

G

peroxisome proliferator-activated receptor delta

decreases expression

Phenformin results in decreased expression of PPARD mRNA

NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968

G

phosphopantothenoylcysteine synthetase

increases expression

Phenformin results in increased expression of PPCS mRNA

NCBI chr 5:133,023,077...133,026,899
Ensembl chr 5:133,023,121...133,026,933

G

protein phosphatase, Mg2+/Mn2+ dependent, 1K

increases expression

Phenformin results in increased expression of PPM1K mRNA

NCBI chr 4:87,612,198...87,638,993
Ensembl chr 4:87,612,204...87,636,152

G

protein phosphatase 1, regulatory subunit 15A

decreases expression

Phenformin results in decreased expression of PPP1R15A mRNA

NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171

G

protein phosphatase 1, regulatory subunit 3B

decreases expression

Phenformin results in decreased expression of PPP1R3B mRNA

NCBI chr16:56,830,011...56,842,395
Ensembl chr16:56,829,660...56,842,406

G

protein regulator of cytokinesis 1

decreases expression

Phenformin results in decreased expression of PRC1 mRNA

NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765

G

DNA primase subunit 1

decreases expression

Phenformin results in decreased expression of PRIM1 mRNA

NCBI chr 7:446,342...462,526
Ensembl chr 7:431,805...462,526

G

protein kinase AMP-activated catalytic subunit alpha 1

increases phosphorylation

Phenformin results in increased phosphorylation of PRKAA1 protein

NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978

G

prospero homeobox 1

increases expression

Phenformin results in increased expression of PROX1 mRNA

NCBI chr13:101,669,184...101,719,804
Ensembl chr13:101,669,184...101,711,183

G

proline rich and Gla domain 4

decreases expression

Phenformin results in decreased expression of PRRG4 mRNA

NCBI chr 3:91,214,646...91,243,347
Ensembl chr 3:91,214,653...91,243,273

G

proteasome 20S subunit beta 8

increases expression

Phenformin results in increased expression of PSMB8 mRNA

NCBI chr20:4,652,159...4,655,122
Ensembl chr20:4,652,159...4,655,283

G

protein tyrosine kinase 6

decreases expression

Phenformin results in decreased expression of PTK6 mRNA

NCBI chr 3:168,307,073...168,315,664
Ensembl chr 3:168,307,073...168,315,664

G

protein tyrosine phosphatase, non-receptor type 3

increases expression

Phenformin results in increased expression of PTPN3 mRNA

NCBI chr 5:71,908,520...72,027,323
Ensembl chr 5:71,911,135...72,065,443

G

pumilio RNA-binding family member 3, pseudogene 3

increases expression

Phenformin results in increased expression of PUM3-PS3 mRNA

NCBI chr12:16,357,131...16,359,221

G

RAB30, member RAS oncogene family

increases expression

Phenformin results in increased expression of RAB30 mRNA

NCBI chr 1:146,803,719...146,898,369
Ensembl chr 1:146,803,714...146,892,181

G

Rap guanine nucleotide exchange factor 5

decreases expression

Phenformin results in decreased expression of RAPGEF5 mRNA

NCBI chr 6:138,445,184...138,679,943
Ensembl chr 6:138,437,991...138,679,936

G

regulator of calcineurin 1

decreases expression

Phenformin results in decreased expression of RCAN1 mRNA

NCBI chr11:31,622,208...31,702,150
Ensembl chr11:31,622,210...31,702,045

G

retinol dehydrogenase 5

decreases expression

Phenformin results in decreased expression of RDH5 mRNA

NCBI chr 7:1,341,172...1,346,863
Ensembl chr 7:1,340,934...1,351,558

G

regenerating family member 3 gamma

increases expression

Phenformin results in increased expression of REG3G mRNA

NCBI chr 4:110,922,805...110,927,803
Ensembl chr 4:110,924,168...110,926,723

G

similar to interferon-inducible GTPase

increases expression

Phenformin results in increased expression of RGD1309362 mRNA

G

regulator of G-protein signaling 2

decreases expression

Phenformin results in decreased expression of RGS2 mRNA

NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385

G

RP1, axonemal microtubule associated

decreases expression

Phenformin results in decreased expression of RP1 mRNA

NCBI chr 5:15,121,104...15,582,363
Ensembl chr 5:15,121,133...15,579,363

G

ribonucleotide reductase regulatory subunit M2

decreases expression

Phenformin results in decreased expression of RRM2 mRNA

NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773

G

RT1 class I, locus A

decreases expression

Phenformin results in decreased expression of RT1-A mRNA

G

SH3 domain binding kinase 1

increases expression

Phenformin results in increased expression of SBK1 mRNA

NCBI chr 1:180,807,092...180,851,910
Ensembl chr 1:180,807,099...180,851,885

G

small Cajal body-specific RNA 15

decreases expression

Phenformin results in decreased expression of SCARNA15 mRNA

NCBI chr 1:135,484,620...135,484,683
Ensembl chr 1:135,484,559...135,484,685
Ensembl chr 1:135,484,559...135,484,685

G

stearoyl-CoA desaturase

decreases expression

Phenformin results in decreased expression of SCD1 mRNA

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

syndecan 4

decreases expression

Phenformin results in decreased expression of SDC4 mRNA

NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580

G

short chain dehydrogenase/reductase family 42E, member 1

increases expression

Phenformin results in increased expression of SDR42E1 mRNA

NCBI chr19:45,715,366...45,727,901
Ensembl chr19:45,715,399...45,727,901

G

serine dehydratase

increases expression

Phenformin results in increased expression of SDS mRNA

NCBI chr12:36,083,226...36,090,540
Ensembl chr12:36,083,229...36,088,203

G

serpin family A member 7

increases expression

Phenformin results in increased expression of SERPINA7 mRNA

NCBI chr X:102,663,242...102,722,319
Ensembl chr X:102,663,405...102,669,040

G

serpin family C member 1

increases activity

Phenformin results in increased activity of SERPINC1 protein

NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293

G

serpin family E member 1

decreases expression

Phenformin results in decreased expression of SERPINE1 mRNA

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

salt-inducible kinase 1

decreases expression

Phenformin results in decreased expression of SIK1 mRNA

NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991

G

sirtuin 1

decreases expression

Phenformin results in decreased expression of SIRT1 protein

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

solute carrier family 10 member 2

decreases expression

Phenformin results in decreased expression of SLC10A2 mRNA

NCBI chr16:84,386,528...84,409,475
Ensembl chr16:84,374,862...84,409,475

G

solute carrier family 10, member 5

decreases expression

Phenformin results in decreased expression of SLC10A5 mRNA

NCBI chr 2:91,457,540...91,458,844
Ensembl chr 2:91,444,454...91,489,651

G

solute carrier family 13 member 2

decreases expression

Phenformin results in decreased expression of SLC13A2 mRNA

NCBI chr10:63,291,813...63,319,127
Ensembl chr10:63,291,815...63,319,127

G

solute carrier family 13 member 3

increases expression

Phenformin results in increased expression of SLC13A3 mRNA

NCBI chr 3:154,141,878...154,204,604
Ensembl chr 3:154,141,872...154,204,606

G

solute carrier family 16 member 10

increases expression

Phenformin results in increased expression of SLC16A10 mRNA

NCBI chr20:43,454,819...43,567,839
Ensembl chr20:43,459,709...43,567,839

G

solute carrier family 17 member 9

decreases expression

Phenformin results in decreased expression of SLC17A9 mRNA

NCBI chr 3:167,839,246...167,857,462
Ensembl chr 3:167,839,385...167,855,985

G

solute carrier family 19 member 3

multiple interactions

Phenformin inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Phenformin inhibits the reaction [SLC19A3 protein results in increased uptake of Thiamine]

NCBI chr 9:84,275,722...84,299,368
Ensembl chr 9:84,277,024...84,299,337

G

solute carrier family 1 member 2

increases expression

Phenformin results in increased expression of SLC1A2 mRNA

NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498

G

solute carrier family 1 member 4

increases expression

Phenformin results in increased expression of SLC1A4 mRNA

NCBI chr14:94,530,801...94,560,190
Ensembl chr14:94,529,084...94,560,418

G

solute carrier family 22 member 2

multiple interactions

Phenformin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 22, member 23

decreases expression

Phenformin results in decreased expression of SLC22A23 mRNA

NCBI chr17:30,544,106...30,709,790
Ensembl chr17:30,544,106...30,709,790

G

solute carrier family 22 member 4

increases response to substance
affects uptake

SLC22A4 protein results in increased susceptibility to Phenformin
SLC22A4 protein affects the uptake of Phenformin

NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720

G

solute carrier family 22 member 5

increases expression

Phenformin results in increased expression of SLC22A5 mRNA

NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309

G

solute carrier family 25 member 23

decreases expression

Phenformin results in decreased expression of SLC25A23 mRNA

NCBI chr 9:1,882,636...1,898,369
Ensembl chr 9:1,882,621...1,898,561

G

solute carrier family 25, member 47

increases expression

Phenformin results in increased expression of SLC25A47 mRNA

NCBI chr 6:127,767,365...127,773,000
Ensembl chr 6:127,767,305...127,773,005

G

solute carrier family 27 member 1

increases expression

Phenformin results in increased expression of SLC27A1 mRNA

NCBI chr16:18,278,984...18,300,173
Ensembl chr16:18,278,984...18,296,063

G

solute carrier family 2 member 12

increases expression

Phenformin results in increased expression of SLC2A12 mRNA

NCBI chr 1:22,803,068...22,862,204
Ensembl chr 1:22,804,418...22,860,971

G

solute carrier family 2 member 5

decreases expression

Phenformin results in decreased expression of SLC2A5 mRNA

NCBI chr 5:160,583,055...160,609,994
Ensembl chr 5:160,583,234...160,611,106

G

solute carrier family 34 member 2

decreases expression

Phenformin results in decreased expression of SLC34A2 mRNA

NCBI chr14:57,910,931...57,930,236
Ensembl chr14:57,910,480...57,930,436

G

solute carrier family 35 member C2

decreases expression

Phenformin results in decreased expression of SLC35C2 mRNA

NCBI chr 3:154,012,262...154,023,549
Ensembl chr 3:154,012,416...154,023,488

G

solute carrier family 38, member 2

decreases expression

Phenformin results in decreased expression of SLC38A2 mRNA

NCBI chr 7:127,851,267...127,863,482
Ensembl chr 7:127,851,267...127,863,436

G

solute carrier family 47 member 1

multiple interactions

Phenformin inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637

G

solute carrier family 47 member 2

multiple interactions

Phenformin inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904

G

solute carrier family 4 member 1 (Diego blood group)

decreases expression

Phenformin results in decreased expression of SLC4A1 mRNA

NCBI chr10:87,306,865...87,323,132
Ensembl chr10:87,306,872...87,323,117

G

solute carrier family 4 member 4

increases expression

Phenformin results in increased expression of SLC4A4 mRNA

NCBI chr14:18,841,289...19,293,297
Ensembl chr14:18,845,159...19,272,883

G

solute carrier family 6 member 6

increases expression

Phenformin results in increased expression of SLC6A6 mRNA

NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875

G

single-pass membrane protein with coiled-coil domains 1

increases expression

Phenformin results in increased expression of SMCO1 mRNA

NCBI chr11:68,512,113...68,514,999
Ensembl chr11:68,509,150...68,515,003

G

snail family transcriptional repressor 2

increases expression

Phenformin results in increased expression of SNAI2 mRNA

NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200

G

syntrophin, beta 1

increases expression

Phenformin results in increased expression of SNTB1 mRNA

NCBI chr 7:87,060,926...87,329,315
Ensembl chr 7:87,060,926...87,329,315

G

suppressor of cytokine signaling 2

decreases expression

Phenformin results in decreased expression of SOCS2 mRNA

NCBI chr 7:30,006,360...30,045,161
Ensembl chr 7:30,008,578...30,043,548

G

serine peptidase inhibitor, Kazal type 1

increases expression

Phenformin results in increased expression of SPINK1 mRNA

NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642

G

sterol regulatory element binding transcription factor 1

decreases expression

Phenformin results in decreased expression of SREBF1 mRNA

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

SH3 and cysteine rich domain 3

decreases expression

Phenformin results in decreased expression of STAC3 mRNA

NCBI chr 7:63,343,078...63,350,590
Ensembl chr 7:63,343,186...63,350,589

G

signal transducer and activator of transcription 3

increases expression

Phenformin results in increased expression of STAT3 mRNA

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

signal transducer and activator of transcription 5B

decreases activity

Phenformin results in decreased activity of STAT5B protein

NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668

G

stathmin 1

decreases expression

Phenformin results in decreased expression of STMN1 mRNA

NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154

G

syntaxin binding protein 6

increases expression

Phenformin results in increased expression of STXBP6 mRNA

NCBI chr 6:61,920,756...62,157,405
Ensembl chr 6:61,920,756...62,158,024

G

T-box transcription factor 3

increases expression

Phenformin results in increased expression of TBX3 mRNA

NCBI chr12:36,879,924...36,894,849
Ensembl chr12:36,881,445...36,893,708

G

titin-cap

increases expression

Phenformin results in increased expression of TCAP mRNA

NCBI chr10:83,381,719...83,382,887
Ensembl chr10:83,381,719...83,382,887

G

testis expressed 36

increases expression

Phenformin results in increased expression of TEX36 mRNA

NCBI chr 1:188,390,062...188,404,448
Ensembl chr 1:188,390,064...188,404,377

G

thrombospondin 1

increases expression

Phenformin results in increased expression of THBS1 mRNA

NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440

G

thyroid hormone responsive

decreases expression

Phenformin results in decreased expression of THRSP mRNA

NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075

G

thymidine kinase 1

decreases expression

Phenformin results in decreased expression of TK1 mRNA

NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920

G

triokinase and FMN cyclase

decreases expression

Phenformin results in decreased expression of TKFC mRNA

NCBI chr 1:207,238,230...207,253,035
Ensembl chr 1:207,236,557...207,252,737

G

transmembrane 7 superfamily member 2

increases expression

Phenformin results in increased expression of TM7SF2 mRNA

NCBI chr 1:203,355,930...203,360,287
Ensembl chr 1:203,355,931...203,360,270

G

transmembrane protein 30B

increases expression

Phenformin results in increased expression of TMEM30B mRNA

NCBI chr 6:92,251,626...92,254,702
Ensembl chr 6:92,249,790...92,254,842

G

transmembrane protein 37

decreases expression

Phenformin results in decreased expression of TMEM37 mRNA

NCBI chr13:31,184,322...31,191,477
Ensembl chr13:31,171,355...31,191,077

G

tropomodulin 4

increases expression

Phenformin results in increased expression of TMOD4 mRNA

NCBI chr 2:182,695,709...182,700,540
Ensembl chr 2:182,695,709...182,700,540

G

TNF alpha induced protein 2

increases expression

Phenformin results in increased expression of TNFAIP2 mRNA

NCBI chr 6:130,476,832...130,489,914
Ensembl chr 6:130,476,889...130,489,914

G

TNF alpha induced protein 3

decreases expression

Phenformin results in decreased expression of TNFAIP3 mRNA

NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282

G

TNF superfamily member 13

decreases expression

Phenformin results in decreased expression of TNFSF13 mRNA

NCBI chr10:54,400,054...54,403,723
Ensembl chr10:54,400,065...54,403,042

G

transducer of ERBB2, 2

decreases expression

Phenformin results in decreased expression of TOB2 mRNA

NCBI chr 7:113,362,703...113,371,423
Ensembl chr 7:113,361,148...113,372,688

G

DNA topoisomerase II alpha

decreases expression

Phenformin results in decreased expression of TOP2A mRNA

NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874

G

tumor protein p53 inducible nuclear protein 1

decreases expression

Phenformin results in decreased expression of TP53INP1 mRNA

NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968

G

tubulin polymerization promoting protein

decreases expression

Phenformin results in decreased expression of TPPP mRNA

NCBI chr 1:29,257,111...29,281,134
Ensembl chr 1:29,261,255...29,281,134

G

TPX2, microtubule nucleation factor

decreases expression

Phenformin results in decreased expression of TPX2 mRNA

NCBI chr 3:141,318,428...141,360,684
Ensembl chr 3:141,318,455...141,360,468

G

tripartite motif-containing 24

increases expression

Phenformin results in increased expression of TRIM24 mRNA

NCBI chr 4:66,567,342...66,692,029
Ensembl chr 4:66,566,686...66,717,241

G

tripartite motif-containing 50

increases expression

Phenformin results in increased expression of TRIM50 mRNA

NCBI chr12:21,300,784...21,317,668
Ensembl chr12:21,300,785...21,317,668

G

TSC22 domain family, member 3

decreases expression

Phenformin results in decreased expression of TSC22D3 mRNA

NCBI chr X:104,217,898...104,277,886
Ensembl chr X:104,217,925...104,276,861

G

tsukushi, small leucine rich proteoglycan

decreases expression

Phenformin results in decreased expression of TSKU mRNA

NCBI chr 1:152,660,259...152,671,682
Ensembl chr 1:152,656,693...152,672,588

G

tetraspanin 4

decreases expression

Phenformin results in decreased expression of TSPAN4 mRNA

NCBI chr 1:196,571,307...196,593,842
Ensembl chr 1:196,572,228...196,617,448

G

Ttk protein kinase

decreases expression

Phenformin results in decreased expression of TTK mRNA

NCBI chr 8:84,754,329...84,792,653
Ensembl chr 8:84,754,315...84,792,651

G

tubulin, beta 1 class VI

decreases expression

Phenformin results in decreased expression of TUBB1 mRNA

NCBI chr 3:163,247,990...163,257,460
Ensembl chr 3:163,247,967...163,256,063

G

tubulin, beta 2A class IIa

decreases expression

Phenformin results in decreased expression of TUBB2A mRNA

NCBI chr17:30,796,842...30,800,713
Ensembl chr17:30,747,503...30,800,714

G

thioredoxin interacting protein

increases expression

Phenformin results in increased expression of TXNIP mRNA

NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886

G

ubiquitin-conjugating enzyme E2C

decreases expression

Phenformin results in decreased expression of UBE2C mRNA

NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339

G

uncoupling protein 3

increases expression

Phenformin results in increased expression of UCP3 mRNA

NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762

G

UDP-glucose 6-dehydrogenase

decreases expression

Phenformin results in decreased expression of UGDH protein

NCBI chr14:42,848,704...42,872,351
Ensembl chr14:42,848,854...42,872,354

G

UDP glucuronosyltransferase family 2 member A3

increases expression

Phenformin results in increased expression of UGT2A3 mRNA

NCBI chr14:20,572,793...20,590,795
Ensembl chr14:20,572,808...20,590,729

G

UDP glucuronosyltransferase 2 family, polypeptide B1

increases expression

Phenformin results in increased expression of UGT2B1 mRNA

NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986

G

UDP glucuronosyltransferase 2 family, polypeptide B34 like 1

increases expression

Phenformin results in increased expression of UGT2B34L1 mRNA

NCBI chr14:21,146,140...21,167,706
Ensembl chr14:21,145,827...21,167,704

G

uridine phosphorylase 2

increases expression

Phenformin results in increased expression of UPP2 mRNA

NCBI chr 3:43,273,048...43,317,417
Ensembl chr 3:43,273,048...43,317,417

G

ubiquitin specific peptidase 18

increases expression

Phenformin results in increased expression of USP18 mRNA

NCBI chr 4:154,471,634...154,499,154
Ensembl chr 4:154,471,592...154,499,144

G

ubiquitin specific peptidase 2

decreases expression

Phenformin results in decreased expression of USP2 mRNA

NCBI chr 8:44,411,457...44,439,668
Ensembl chr 8:44,411,607...44,438,331

G

vestigial-like family member 4

decreases expression

Phenformin results in decreased expression of VGLL4 mRNA

NCBI chr 4:147,925,630...148,038,519
Ensembl chr 4:147,927,034...148,038,471

G

vanin 1

increases expression

Phenformin results in increased expression of VNN1 mRNA

NCBI chr 1:21,537,084...21,547,395
Ensembl chr 1:21,537,094...21,547,395

G

WEE1 G2 checkpoint kinase

decreases expression

Phenformin results in decreased expression of WEE1 mRNA

NCBI chr 1:164,173,681...164,197,688
Ensembl chr 1:164,174,779...164,197,688

G

X-linked inhibitor of apoptosis

increases expression

Phenformin results in increased expression of XIAP mRNA

NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700

G

yippee-like 2

decreases expression

Phenformin results in decreased expression of YPEL2 mRNA

NCBI chr10:71,746,308...71,803,843
Ensembl chr10:71,746,311...71,803,911

G

zinc finger and BTB domain containing 16

decreases expression

Phenformin results in decreased expression of ZBTB16 mRNA

NCBI chr 8:48,989,376...49,177,011
Ensembl chr 8:48,994,566...49,177,011

G

zinc finger protein 354A

decreases expression

Phenformin results in decreased expression of ZFP354A mRNA

NCBI chr10:35,396,242...35,408,069
Ensembl chr10:35,396,231...35,408,068

G

zinc finger protein 36

decreases expression

Phenformin results in decreased expression of ZFP36 mRNA

NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564

G

zinc finger protein 750

increases expression

Phenformin results in increased expression of ZNF750 mRNA

NCBI chr10:106,772,162...106,781,186
Ensembl chr10:106,772,669...106,781,200

phenyl biguanide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

tachykinin receptor 1

increases response to substance

TACR1 protein results in increased susceptibility to phenyl biguanide

NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19917
chemical entity	19915
atom	19915
nonmetal atom	19838
nitrogen atom	19015
nitrogen molecular entity	19015
organonitrogen compound	18866
guanidines	2336
biguanide	1136
buformin	0
chlorhexidine +	5
metformin	885
phenformin	422
phenyl biguanide	1
Path 2
Term	Annotations
CHEBI ontology	19917
subatomic particle	19915
composite particle	19915
hadron	19915
baryon	19915
nucleon	19915
atomic nucleus	19915
atom	19915
main group element atom	19855
main group molecular entity	19855
p-block molecular entity	19855
carbon group molecular entity	19794
organic molecular entity	19790
heteroorganic entity	19548
organonitrogen compound	18866
guanidines	2336
biguanide	1136
buformin	0
chlorhexidine +	5
metformin	885
phenformin	422
phenyl biguanide	1

paths to the root