CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: biguanide
Accession: CHEBI:3095
browse the term
Definition: A guanidine that has formula C2H7N5.
Synonyms: exact_synonym: 1,2,3-triimidodicarbonic diamide
related_synonym: Formula=C2H7N5; H2N-C(=NH)-NH-C(=NH)-NH2; Hbig; InChI=1S/C2H7N5/c3-1(4)7-2(5)6/h(H7,3,4,5,6,7); InChIKey=XNCOSPRUTUOJCJ-UHFFFAOYSA-N; SMILES=NC(=N)NC(N)=N; imidodicarbonimidic diamide
xref: Beilstein:507183; CAS:56-03-1; Gmelin:240093; KEGG:C07672
G
Ache
acetylcholinesterase
decreases activity
ISO
Chlorhexidine results in decreased activity of ACHE protein
CTD
PMID:33844597
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
G
Hspa5
heat shock protein family A (Hsp70) member 5
increases expression
ISO
Chlorhexidine results in increased expression of HSPA5 protein
CTD
PMID:19027770
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
G
Iyd
iodotyrosine deiodinase
multiple interactions
ISO
Chlorhexidine inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine]
CTD
PMID:33352258
NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319
G
Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Chlorhexidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
G
Gpt
glutamic--pyruvic transaminase
increases secretion
EXP
chlorhexidine gluconate results in increased secretion of GPT protein
CTD
PMID:145039
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
G
Aacs
acetoacetyl-CoA synthetase
increases expression
EXP
Metformin results in increased expression of AACS mRNA
CTD
PMID:31324951
NCBI chr12:31,113,098...31,156,411
Ensembl chr12:31,113,098...31,160,954
G
Aars1
alanyl-tRNA synthetase 1
increases expression
EXP
Metformin results in increased expression of AARS1 mRNA
CTD
PMID:25596134
NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147
G
Abcb11
ATP binding cassette subfamily B member 11
decreases expression multiple interactions
EXP ISO
Metformin results in decreased expression of ABCB11 mRNA [Metformin co-treated with Ethinyl Estradiol] results in decreased expression of ABCB11 protein
CTD
PMID:27765674 PMID:34058177
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
G
Abcb1a
ATP binding cassette subfamily B member 1A
multiple interactions decreases expression
ISO
Metformin inhibits the reaction [Doxorubicin results in increased expression of ABCB1 mRNA]; Metformin inhibits the reaction [RELA protein results in increased expression of ABCB1 mRNA]; Metformin inhibits the reaction [TNF protein results in increased expression of ABCB1 mRNA]; Metformin inhibits the reaction [TNF protein results in increased expression of ABCB1 protein]; PRKAA1 protein affects the reaction [Metformin results in decreased expression of ABCB1 protein] Metformin results in decreased expression of ABCB1 mRNA; Metformin results in decreased expression of ABCB1 protein
CTD
PMID:21054339
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
G
Abcb1b
ATP-binding cassette, sub-family B member 1B
increases expression
EXP
Metformin results in increased expression of ABCB1B mRNA
CTD
PMID:19022234
NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
G
Abcb4
ATP binding cassette subfamily B member 4
increases expression
EXP
Metformin results in increased expression of ABCB4 mRNA
CTD
PMID:31324951
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
G
Abcb6
ATP binding cassette subfamily B member 6
decreases expression
EXP
Metformin results in decreased expression of ABCB6 mRNA
CTD
PMID:25596134
NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924
G
Abcb9
ATP binding cassette subfamily B member 9
affects expression
EXP
Metformin affects the expression of ABCB9 mRNA
CTD
PMID:25596134
NCBI chr12:32,499,213...32,531,932
Ensembl chr12:32,499,225...32,531,931
G
Abcc2
ATP binding cassette subfamily C member 2
increases expression
ISO
Metformin results in increased expression of ABCC2 mRNA
CTD
PMID:19022234
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
G
Abcc3
ATP binding cassette subfamily C member 3
decreases expression
EXP
Metformin results in decreased expression of ABCC3 mRNA
CTD
PMID:25596134
NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
G
Abcc4
ATP binding cassette subfamily C member 4
multiple interactions
ISO
Metformin inhibits the reaction [Ethinyl Estradiol results in increased expression of ABCC4 protein]
CTD
PMID:34058177
NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
G
Abcc5
ATP binding cassette subfamily C member 5
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of ABCC5 mRNA]
CTD
PMID:29095437
NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253
G
Abcc9
ATP binding cassette subfamily C member 9
multiple interactions
ISO
[rosiglitazone co-treated with Metformin] results in increased expression of ABCC9 mRNA alternative form; [rosiglitazone co-treated with Metformin] results in increased expression of ABCC9 protein alternative form
CTD
PMID:20823565
NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356
G
Abcg5
ATP binding cassette subfamily G member 5
decreases expression increases expression
EXP
Metformin results in decreased expression of ABCG5 mRNA Metformin results in increased expression of ABCG5 mRNA
CTD
PMID:27765674 PMID:31324951
NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
G
Abcg8
ATP binding cassette subfamily G member 8
increases expression
EXP
Metformin results in increased expression of ABCG8 mRNA
CTD
PMID:31324951
NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912
G
Abhd4
abhydrolase domain containing 4, N-acyl phospholipase B
decreases expression
EXP
Metformin results in decreased expression of ABHD4 mRNA
CTD
PMID:25596134
NCBI chr15:27,697,384...27,716,013
Ensembl chr15:27,704,113...27,716,966
G
Abl1
ABL proto-oncogene 1, non-receptor tyrosine kinase
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of ABL1 mRNA
CTD
PMID:29309887
NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065
G
Ablim3
actin binding LIM protein family, member 3
increases expression
EXP
Metformin results in increased expression of ABLIM3 mRNA
CTD
PMID:31324951
NCBI chr18:55,256,135...55,376,629
Ensembl chr18:55,257,583...55,376,380
G
Acaca
acetyl-CoA carboxylase alpha
decreases expression multiple interactions increases expression increases phosphorylation affects phosphorylation
ISO EXP
Metformin results in decreased expression of ACACA mRNA; Metformin results in decreased expression of ACACA protein Metformin inhibits the reaction [INS protein results in increased phosphorylation of ACACA protein] Metformin results in increased expression of ACACA protein modified form Metformin inhibits the reaction [Olanzapine results in decreased expression of ACACA mRNA] Metformin results in increased expression of ACACA mRNA Metformin results in increased phosphorylation of ACACA protein Trientine inhibits the reaction [Metformin results in increased phosphorylation of ACACA protein] Metformin analog affects the phosphorylation of ACACA protein
CTD
PMID:16760380 PMID:16873680 PMID:20956498 PMID:22492524 PMID:29991592 PMID:31324951 PMID:32652086 PMID:33838154 PMID:36764371 More...
NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
G
Acacb
acetyl-CoA carboxylase beta
increases phosphorylation
ISO
Metformin results in increased phosphorylation of ACACB protein
CTD
PMID:16873680
NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655
G
Acat2
acetyl-CoA acetyltransferase 2
increases expression
EXP
Metformin results in increased expression of ACAT2 mRNA
CTD
PMID:31324951
NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821
G
Ace
angiotensin I converting enzyme
multiple interactions
ISO
Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of ACE mRNA]
CTD
PMID:37120126
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
G
Ace2
angiotensin converting enzyme 2
increases expression multiple interactions
ISO
Metformin results in increased expression of ACE2 mRNA Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of ACE2 mRNA]
CTD
PMID:32808185 PMID:37120126
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
G
Ache
acetylcholinesterase
decreases activity multiple interactions
ISO EXP
Metformin results in decreased activity of ACHE protein Metformin inhibits the reaction [[Fructose co-treated with Streptozocin] results in increased expression of ACHE protein]; Metformin inhibits the reaction [Chlorpyrifos results in decreased activity of ACHE protein]
CTD
PMID:28259689 PMID:33823243 PMID:35448458
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
G
Acly
ATP citrate lyase
multiple interactions affects expression
ISO EXP
[Metformin co-treated with caffeic acid] results in decreased expression of ACLY protein Metformin affects the expression of ACLY mRNA
CTD
PMID:28576465 PMID:31324951
NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
G
Acmsd
aminocarboxymuconate semialdehyde decarboxylase
decreases expression
EXP
Metformin results in decreased expression of ACMSD mRNA
CTD
PMID:31324951
NCBI chr13:39,200,412...39,245,954
Ensembl chr13:39,200,314...39,245,209
G
Acot2
acyl-CoA thioesterase 2
increases expression
EXP
Metformin results in increased expression of ACOT2 mRNA
CTD
PMID:31324951
NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245
G
Acot3
acyl-CoA thioesterase 3
increases expression
EXP
Metformin results in increased expression of ACOT3 mRNA
CTD
PMID:31324951
NCBI chr 6:103,682,518...103,688,735
Ensembl chr 6:103,682,596...103,688,427 Ensembl chr 6:103,682,596...103,688,427
G
Acsl1
acyl-CoA synthetase long-chain family member 1
decreases expression multiple interactions
EXP ISO
Metformin results in decreased expression of ACSL1 mRNA Metformin inhibits the reaction [Oxygen deficiency results in increased expression of ACSL1 mRNA]
CTD
PMID:25596134 PMID:33476677
NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
G
Acsm3
acyl-CoA synthetase medium-chain family member 3
increases expression
EXP
Metformin results in increased expression of ACSM3 mRNA
CTD
PMID:31324951
NCBI chr 1:174,133,260...174,159,966
Ensembl chr 1:174,133,288...174,160,184
G
Acta1
actin, alpha 1, skeletal muscle
increases expression
EXP
Metformin results in increased expression of ACTA1 mRNA
CTD
PMID:31324951
NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742
G
Acta2
actin alpha 2, smooth muscle
multiple interactions
EXP
Metformin inhibits the reaction [Dietary Fats results in increased expression of ACTA2 protein]; Metformin promotes the reaction [dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of ACTA2 protein]]
CTD
PMID:27551045 PMID:30551545
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
G
Actn1
actinin, alpha 1
increases expression
EXP
Metformin results in increased expression of ACTN1 mRNA
CTD
PMID:19022234
NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251
G
Adgre1
adhesion G protein-coupled receptor E1
multiple interactions
ISO
Metformin inhibits the reaction [Folic Acid results in increased expression of ADGRE1 mRNA]
CTD
PMID:29380373
NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000
G
Adh4
alcohol dehydrogenase 4 (class II), pi polypeptide
decreases expression
EXP
Metformin results in decreased expression of ADH4 mRNA
CTD
PMID:31324951
NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591
G
Adipoq
adiponectin, C1Q and collagen domain containing
decreases expression multiple interactions increases expression
ISO EXP
Metformin results in decreased expression of ADIPOQ mRNA Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of ADIPOQ protein]; Metformin inhibits the reaction [Olanzapine results in decreased expression of ADIPOQ protein] Metformin results in increased expression of ADIPOQ protein Metformin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein]; Metformin inhibits the reaction [Palmitic Acid results in decreased expression of ADIPOQ mRNA] Cimetidine promotes the reaction [Metformin results in decreased expression of ADIPOQ mRNA]
CTD
PMID:20956498 PMID:25108154 PMID:30256492 PMID:32652086 PMID:37337224
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
G
Adipor1
adiponectin receptor 1
increases expression
EXP
Metformin results in increased expression of ADIPOR1 mRNA
CTD
PMID:29991592
NCBI chr13:45,859,461...45,879,248
Ensembl chr13:45,859,533...45,879,241
G
Adipor2
adiponectin receptor 2
increases expression
EXP
metformin increases expression of Adipor2 mRNA in liver
RGD
PMID:24797033
RGD:25824940
NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355
G
Aen
apoptosis enhancing nuclease
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of AEN mRNA]
CTD
PMID:29095437
NCBI chr 1:132,815,094...132,824,522
Ensembl chr 1:132,815,142...132,824,523
G
Ager
advanced glycosylation end product-specific receptor
multiple interactions
EXP
Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGER protein]; Metformin inhibits the reaction [Glucose promotes the reaction [Linoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]; Metformin inhibits the reaction [Linoleic Acid promotes the reaction [Glucose promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]
CTD
PMID:22467055 PMID:36999408
NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
G
Agrn
agrin
decreases expression
EXP
Metformin results in decreased expression of AGRN mRNA
CTD
PMID:25596134
NCBI chr 5:166,749,306...166,782,212
Ensembl chr 5:166,749,310...166,786,003
G
Agrp
agouti related neuropeptide
multiple interactions
ISO
Metformin inhibits the reaction [Olanzapine results in increased expression of AGRP mRNA]
CTD
PMID:32652086
NCBI chr19:33,447,992...33,481,602
Ensembl chr19:33,447,992...33,449,584
G
Agt
angiotensinogen
multiple interactions
ISO
Metformin inhibits the reaction [AGT protein results in increased activity of and results in increased phosphorylation of HMGCR protein]; Metformin inhibits the reaction [AGT protein results in increased cleavage of and affects the localization of SREBF2 protein]; Metformin inhibits the reaction [AGT protein results in increased expression of LDLR protein]; Metformin inhibits the reaction [AGT protein results in increased expression of SREBF2 protein]; Metformin inhibits the reaction [AGT protein results in increased secretion of CCL2 protein]; Metformin inhibits the reaction [AGT protein results in increased secretion of TNF protein]
CTD
PMID:29499335
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
ISO
Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of AGTR1A mRNA]
CTD
PMID:37120126
NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
G
Ahr
aryl hydrocarbon receptor
decreases expression affects activity multiple interactions
ISO EXP
Metformin results in decreased expression of AHR mRNA; Metformin results in decreased expression of AHR protein Metformin affects the activity of AHR protein Metformin inhibits the reaction [SP1 protein results in increased expression of AHR protein]; Metformin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of AHR protein]
CTD
PMID:25110054 PMID:25596134 PMID:25697376
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
G
Aifm1
apoptosis inducing factor, mitochondria associated 1
multiple interactions
ISO
Metformin inhibits the reaction [Acetaminophen affects the localization of AIFM1 protein]
CTD
PMID:27562556
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
G
Aifm2
AIF family member 2
decreases expression
EXP
Metformin results in decreased expression of AIFM2 mRNA
CTD
PMID:25596134
NCBI chr20:29,654,283...29,679,239
Ensembl chr20:29,652,927...29,679,236
G
Ak3
adenylate kinase 3
decreases expression
EXP
Metformin results in decreased expression of AK3 mRNA
CTD
PMID:25596134
NCBI chr 1:226,737,472...226,764,647
Ensembl chr 1:226,739,318...226,764,625
G
Ak4
adenylate kinase 4
decreases expression
EXP
Metformin results in decreased expression of AK4 mRNA
CTD
PMID:25596134
NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618
G
Akr1b8-ps2
aldo-keto reductase family 1, member B8, pseudogene 2
decreases expression
EXP
Metformin results in decreased expression of AKR1B8-PS2 mRNA
CTD
PMID:31324951
NCBI chr 6:77,569,720...77,571,967
G
Akt1
AKT serine/threonine kinase 1
multiple interactions affects phosphorylation increases phosphorylation decreases phosphorylation
ISO EXP
[Metformin co-treated with IGF1 protein] results in increased phosphorylation of AKT1 protein; [Metformin co-treated with IGF2 protein] results in increased phosphorylation of AKT1 protein; [Metformin co-treated with INS protein] results in increased phosphorylation of AKT1 protein; [Paclitaxel co-treated with Metformin] results in decreased expression of AKT1 mRNA; [Simvastatin co-treated with Metformin] results in decreased phosphorylation of AKT1 protein; AKT1 protein modified form inhibits the reaction [Metformin promotes the reaction [plantamajoside results in decreased phosphorylation of AKT1 protein]]; AKT1 protein modified form inhibits the reaction [Metformin promotes the reaction [plantamajoside results in decreased phosphorylation of GSK3B protein]]; AKT1 protein mutant form inhibits the reaction [[Metformin co-treated with NVP-BKM120] results in increased expression of BBC3 protein]; Metformin inhibits the reaction [Glucose results in increased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [INS protein results in decreased phosphorylation of AKT1 protein]; Metformin promotes the reaction [plantamajoside results in decreased phosphorylation of AKT1 protein] Metformin affects the phosphorylation of AKT1 protein Metformin results in increased phosphorylation of AKT1 protein Metformin decreases phosphorylation of AKT1 protein in epithelial cell of alveolus of lung Metformin inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [Olanzapine results in decreased expression of AKT1 mRNA]; Metformin inhibits the reaction [Streptozocin results in decreased phosphorylation of AKT1 protein] Metformin inhibits the reaction [[Streptozocin co-treated with Coconut Oil co-treated with Cholesterol] results in decreased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [Methamphetamine results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [Streptozocin results in increased expression of AKT1 mRNA]; Metformin inhibits the reaction [Testosterone results in increased phosphorylation of AKT1 protein]
CTD RGD
PMID:16385087 PMID:21664031 PMID:25412314 PMID:26492952 PMID:26835874 PMID:29309887 PMID:30742852 PMID:30914352 PMID:30928401 PMID:31743741 PMID:31877369 PMID:32652086 PMID:34649470 PMID:35199402 PMID:35350904 PMID:35414346 PMID:36764371 PMID:38479708 PMID:23632475 More...
RGD:150404268
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
G
Akt2
AKT serine/threonine kinase 2
multiple interactions
EXP
Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of AKT2 protein]
CTD
PMID:27270450
NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
G
Akt3
AKT serine/threonine kinase 3
decreases expression
ISO
Metformin results in decreased expression of AKT3 mRNA
CTD
PMID:32589349
NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708
G
Alas2
5'-aminolevulinate synthase 2
decreases expression
EXP
Metformin results in decreased expression of ALAS2 mRNA
CTD
PMID:31324951
NCBI chr X:19,463,146...19,486,526
Ensembl chr X:19,463,171...19,486,519
G
Alb
albumin
multiple interactions
EXP
Metformin inhibits the reaction [Streptozocin results in increased expression of ALB protein]
CTD
PMID:33639173
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
G
Aldh18a1
aldehyde dehydrogenase 18 family, member A1
increases expression
EXP
Metformin results in increased expression of ALDH18A1 mRNA
CTD
PMID:25596134
NCBI chr 1:239,375,657...239,407,956
Ensembl chr 1:239,375,669...239,407,890
G
Aldh1a1
aldehyde dehydrogenase 1 family, member A1
increases expression
EXP
Metformin results in increased expression of ALDH1A1 mRNA
CTD
PMID:31324951
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
G
Aldoa
aldolase, fructose-bisphosphate A
increases expression
EXP
Metformin results in increased expression of ALDOA mRNA
CTD
PMID:25596134
NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182
G
Alox15
arachidonate 15-lipoxygenase
decreases expression
EXP
Metformin results in decreased expression of ALOX15 mRNA
CTD
PMID:31324951
NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
G
Alpl
alkaline phosphatase, biomineralization associated
multiple interactions
ISO
Metformin inhibits the reaction [BMP2 protein results in increased expression of ALPL mRNA]
CTD
PMID:37409753
NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
G
Ambp
alpha-1-microglobulin/bikunin precursor
decreases expression
EXP
Metformin results in decreased expression of AMBP mRNA
CTD
PMID:25596134
NCBI chr 5:76,568,094...76,578,416
Ensembl chr 5:76,568,094...76,578,331
G
Angpt1
angiopoietin 1
decreases expression
EXP
Metformin results in decreased expression of ANGPT1 mRNA
CTD
PMID:31324951
NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067
G
Angptl4
angiopoietin-like 4
decreases expression increases expression
EXP
Metformin results in decreased expression of ANGPTL4 mRNA Metformin results in increased expression of ANGPTL4 mRNA
CTD
PMID:25596134 PMID:31324951
NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
G
Angptl8
angiopoietin-like 8
increases expression
EXP
Metformin results in increased expression of ANGPTL8 mRNA
CTD
PMID:31324951
NCBI chr 8:20,376,462...20,378,488
Ensembl chr 8:20,376,462...20,378,490
G
Apaf1
apoptotic peptidase activating factor 1
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in increased expression of APAF1 mRNA
CTD
PMID:29309887
NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
G
Apex1
apurinic/apyrimidinic endodeoxyribonuclease 1
multiple interactions
ISO
Metformin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of APEX1 mRNA]
CTD
PMID:25697376
NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
G
Apoa5
apolipoprotein A5
decreases expression
EXP
Metformin results in decreased expression of APOA5 mRNA
CTD
PMID:31324951
NCBI chr 8:46,561,180...46,563,818
Ensembl chr 8:46,561,229...46,563,816
G
Apof
apolipoprotein F
decreases expression
EXP
Metformin results in decreased expression of APOF mRNA
CTD
PMID:31324951
NCBI chr 7:700,688...702,130
Ensembl chr 7:700,762...701,946
G
Appl1
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
multiple interactions increases expression
EXP
Metformin promotes the reaction [APPL1 protein binds to RAB5A protein] Metformin results in increased expression of APPL1 protein
CTD
PMID:29991592
NCBI chr16:2,118,503...2,166,741
Ensembl chr16:2,121,255...2,166,692
G
Aqp7
aquaporin 7
increases expression
EXP
Metformin results in increased expression of AQP7 mRNA
CTD
PMID:31324951
NCBI chr 5:56,171,649...56,186,642
Ensembl chr 5:56,172,519...56,186,642
G
Arfgap3
ADP-ribosylation factor GTPase activating protein 3
increases expression
EXP
Metformin results in increased expression of ARFGAP3 mRNA
CTD
PMID:31324951
NCBI chr 7:114,432,873...114,479,206
Ensembl chr 7:114,432,873...114,479,208
G
Arfgef2
ADP ribosylation factor guanine nucleotide exchange factor 2
increases expression
EXP
Metformin results in increased expression of ARFGEF2 mRNA
CTD
PMID:25596134
NCBI chr 3:155,547,504...155,633,652
Ensembl chr 3:155,547,538...155,630,856
G
Arg1
arginase 1
multiple interactions
EXP ISO
Metformin inhibits the reaction [Palmitic Acid results in decreased expression of ARG1 mRNA] Metformin inhibits the reaction [IL13 protein results in increased expression of ARG1 mRNA]
CTD
PMID:25108154 PMID:26497364
NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
G
Arhgef10
Rho guanine nucleotide exchange factor 10
decreases expression
EXP
Metformin results in decreased expression of ARHGEF10 mRNA
CTD
PMID:25596134
NCBI chr16:74,647,147...74,738,784
Ensembl chr16:74,647,153...74,738,173
G
Arl1
ADP-ribosylation factor like GTPase 1
decreases expression
EXP
Metformin results in decreased expression of ARL1 mRNA
CTD
PMID:25596134
NCBI chr 7:23,120,004...23,131,173
Ensembl chr 7:23,119,589...23,131,898
G
Arpc5l
actin related protein 2/3 complex, subunit 5-like
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of ARPC5L mRNA]
CTD
PMID:29095437
NCBI chr 3:22,758,710...22,767,520
Ensembl chr 3:22,759,876...22,767,538 Ensembl chr 9:22,759,876...22,767,538
G
Arrdc3
arrestin domain containing 3
decreases expression
EXP
Metformin results in decreased expression of ARRDC3 mRNA
CTD
PMID:31324951
NCBI chr 2:11,137,464...11,149,978
Ensembl chr 2:11,137,460...11,149,978
G
Asl
argininosuccinate lyase
decreases expression
EXP
Metformin results in decreased expression of ASL mRNA
CTD
PMID:31324951
NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662
G
Asns
asparagine synthetase (glutamine-hydrolyzing)
increases expression
EXP
Metformin results in increased expression of ASNS mRNA
CTD
PMID:25596134 PMID:31324951
NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
G
Atf3
activating transcription factor 3
increases expression
EXP
Metformin results in increased expression of ATF3 mRNA
CTD
PMID:25596134
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
G
Atf4
activating transcription factor 4
affects activity multiple interactions
EXP ISO
Metformin affects the activity of ATF4 protein Metformin inhibits the reaction [Rotenone results in increased expression of ATF4 mRNA]
CTD
PMID:25596134 PMID:32189544
NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
G
Atf5
activating transcription factor 5
increases expression
EXP
Metformin results in increased expression of ATF5 mRNA
CTD
PMID:31324951
NCBI chr 1:95,295,602...95,299,755
Ensembl chr 1:95,295,610...95,299,707
G
Atf6
activating transcription factor 6
multiple interactions
ISO EXP
Metformin inhibits the reaction [Rotenone results in increased expression of ATF6 mRNA] Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of ATF6 protein]; Metformin inhibits the reaction [Glucose results in increased expression of and affects the localization of ATF6 protein]
CTD
PMID:32189544 PMID:34801538
NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
G
Atg5
autophagy related 5
multiple interactions
EXP
Metformin inhibits the reaction [Blood Glucose results in increased expression of ATG5 protein]
CTD
PMID:33021114
NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
G
Atm
ATM serine/threonine kinase
affects response to substance increases expression
ISO
ATM gene SNP affects the susceptibility to Metformin Metformin increases expression of ATM protein in epithelial cell of alveolus of lung
CTD RGD
PMID:21186350 PMID:23632475
RGD:150404268
NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
G
Atosa
atos homolog A
decreases expression
EXP
Metformin results in decreased expression of ATOSA mRNA
CTD
PMID:25596134
NCBI chr 8:75,694,828...75,772,565
Ensembl chr 8:75,695,022...75,772,549
G
Atp1a2
ATPase Na+/K+ transporting subunit alpha 2
decreases expression
EXP
Metformin results in decreased expression of ATP1A2 mRNA
CTD
PMID:31324951
NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544
G
Atp1a3
ATPase Na+/K+ transporting subunit alpha 3
increases expression
EXP
Metformin results in increased expression of ATP1A3 mRNA
CTD
PMID:31324951
NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918
G
Atp2a2
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
multiple interactions
EXP
Metformin inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary] results in decreased expression of ATP2A2 protein]
CTD
PMID:30290168
NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
G
Atp5mc2
ATP synthase membrane subunit c locus 2
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of ATP5MC2 mRNA]
CTD
PMID:29095437
NCBI chr 7:133,791,341...133,799,713
Ensembl chr 7:133,791,342...133,799,733
G
Atp6v0d2
ATPase H+ transporting V0 subunit D2
decreases expression
EXP
Metformin results in decreased expression of ATP6V0D2 mRNA
CTD
PMID:31324951
NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354
G
Atr
ATR serine/threonine kinase
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of ATR mRNA
CTD
PMID:29309887
NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136
G
Aurkb
aurora kinase B
increases expression
EXP
Metformin results in increased expression of AURKB mRNA
CTD
PMID:25596134
NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
G
Aven
apoptosis and caspase activation inhibitor
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of AVEN mRNA
CTD
PMID:29309887
NCBI chr 3:99,299,009...99,431,635
Ensembl chr 3:99,298,930...99,431,634
G
B2m
beta-2 microglobulin
multiple interactions
EXP ISO
Metformin inhibits the reaction [Streptozocin results in increased expression of B2M protein]
CTD
PMID:33639173 PMID:34649470
NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
G
Bad
BCL2-associated agonist of cell death
increases expression multiple interactions
ISO
Metformin results in increased expression of BAD protein Cisplatin promotes the reaction [Metformin results in increased expression of BAD protein]; Metformin inhibits the reaction [INS protein results in decreased expression of BAD protein]
CTD
PMID:21388661 PMID:33651899
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
G
Bag1
BAG cochaperone 1
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of BAG1 mRNA
CTD
PMID:29309887
NCBI chr 5:56,068,494...56,081,075
Ensembl chr 5:56,068,494...56,081,075
G
Bax
BCL2 associated X, apoptosis regulator
multiple interactions affects expression increases expression
ISO EXP
Cisplatin promotes the reaction [Metformin results in increased expression of BAX protein] Metformin inhibits the reaction [Streptozocin results in increased expression of BAX protein]; SIRT3 protein promotes the reaction [Metformin inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]]; SIRT3 protein promotes the reaction [Metformin inhibits the reaction [Cisplatin results in increased expression of BAX protein]] Metformin affects the expression of BAX protein Metformin inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]; Metformin inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Metformin inhibits the reaction [Glucose results in increased expression of BAX protein]; Metformin inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]; Metformin inhibits the reaction [Testosterone results in decreased expression of BAX mRNA] Metformin results in increased expression of BAX mRNA
CTD
PMID:21388661 PMID:25596134 PMID:26492952 PMID:28106847 PMID:29226720 PMID:30144576 PMID:34649470 PMID:35414346 PMID:36800006 More...
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
G
Bbc3
Bcl-2 binding component 3
multiple interactions
ISO
[Metformin co-treated with NVP-BKM120] results in increased expression of BBC3 mRNA; [Metformin co-treated with NVP-BKM120] results in increased expression of BBC3 protein; AKT1 protein mutant form inhibits the reaction [[Metformin co-treated with NVP-BKM120] results in increased expression of BBC3 protein]; BBC3 protein promotes the reaction [[Metformin co-treated with NVP-BKM120] results in increased cleavage of CASP3 protein]; FOXO3 protein promotes the reaction [[Metformin co-treated with NVP-BKM120] results in increased expression of BBC3 protein]
CTD
PMID:38479708
NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
G
Bcar3
BCAR3 adaptor protein, NSP family member
affects expression
EXP
Metformin affects the expression of BCAR3 mRNA
CTD
PMID:25596134
NCBI chr 2:210,525,260...210,638,674
Ensembl chr 2:210,525,260...210,638,798
G
Bcat2
branched chain amino acid transaminase 2
decreases expression
EXP
Metformin results in decreased expression of BCAT2 mRNA
CTD
PMID:25596134 PMID:31324951
NCBI chr 1:96,040,407...96,060,008
Ensembl chr 1:96,042,625...96,060,007
G
Bcl2
BCL2, apoptosis regulator
decreases expression multiple interactions
ISO EXP
Metformin results in decreased expression of BCL2 protein Metformin inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein] Metformin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Metformin inhibits the reaction [Glucose results in decreased expression of BCL2 protein]; Metformin inhibits the reaction [Streptozocin results in increased expression of BCL2 mRNA]; Metformin inhibits the reaction [Testosterone results in increased expression of BCL2 mRNA] [Paclitaxel co-treated with Metformin] results in decreased expression of BCL2 mRNA; Cisplatin promotes the reaction [Metformin results in decreased expression of BCL2 protein]
CTD
PMID:21388661 PMID:26492952 PMID:26818447 PMID:28106847 PMID:29226720 PMID:29309887 PMID:30144576 PMID:34649470 PMID:34801538 PMID:35414346 More...
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Bcl2l1
Bcl2-like 1
multiple interactions decreases expression
ISO EXP
Cisplatin promotes the reaction [Metformin results in decreased expression of BCL2L1 protein] Metformin inhibits the reaction [Streptozocin results in increased expression of BCL2L1 mRNA]
CTD
PMID:21388661 PMID:35414346
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
G
Bcl6
BCL6, transcription repressor
increases expression
EXP
Metformin results in increased expression of BCL6 mRNA
CTD
PMID:31324951
NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
G
Bdnf
brain-derived neurotrophic factor
multiple interactions
EXP
Metformin inhibits the reaction [Methamphetamine results in decreased expression of BDNF protein]; Metformin inhibits the reaction [Streptozocin results in increased expression of BDNF mRNA]
CTD
PMID:30742852 PMID:35414346
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
G
Becn1
beclin 1
increases expression multiple interactions
ISO EXP
Metformin results in increased expression of BECN1 protein Metformin inhibits the reaction [Blood Glucose results in increased expression of BECN1 protein]; Metformin inhibits the reaction [Blood Glucose results in increased phosphorylation of BECN1 protein] plantamajoside promotes the reaction [Metformin results in increased expression of BECN1 protein]
CTD
PMID:33021114 PMID:35350904
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
G
Bhlhe40
basic helix-loop-helix family, member e40
affects expression
EXP
Metformin affects the expression of BHLHE40 mRNA
CTD
PMID:25596134
NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774
G
Birc5
baculoviral IAP repeat-containing 5
decreases expression
ISO
Metformin results in decreased expression of BIRC5 protein
CTD
PMID:29226720
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
G
Bmal1
basic helix-loop-helix ARNT like 1
decreases expression
EXP
Metformin results in decreased expression of BMAL1 mRNA
CTD
PMID:31324951
NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231
G
Bmf
Bcl2 modifying factor
decreases expression
EXP
Metformin results in decreased expression of BMF mRNA
CTD
PMID:25596134
NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145
G
Bmp2
bone morphogenetic protein 2
multiple interactions
ISO
Metformin inhibits the reaction [BMP2 protein results in decreased expression of CDH1 mRNA]; Metformin inhibits the reaction [BMP2 protein results in increased expression of ALPL mRNA]; Metformin inhibits the reaction [BMP2 protein results in increased expression of BMP4 mRNA]; Metformin inhibits the reaction [BMP2 protein results in increased expression of RUNX2 mRNA]; Metformin inhibits the reaction [BMP2 protein results in increased expression of RUNX2 protein]; Metformin inhibits the reaction [BMP2 protein results in increased expression of SP7 mRNA]; Metformin inhibits the reaction [BMP2 protein results in increased expression of SP7 protein]; Metformin inhibits the reaction [BMP2 protein results in increased expression of VIM mRNA]
CTD
PMID:37409753
NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
G
Bmp4
bone morphogenetic protein 4
multiple interactions
ISO
Metformin inhibits the reaction [BMP2 protein results in increased expression of BMP4 mRNA]
CTD
PMID:37409753
NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
G
Bnip3
BCL2 interacting protein 3
increases expression
EXP
Metformin results in increased expression of BNIP3 mRNA
CTD
PMID:25596134
NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
G
Bpgm
bisphosphoglycerate mutase
decreases expression
EXP
Metformin results in decreased expression of BPGM mRNA
CTD
PMID:31324951
NCBI chr 4:63,139,730...63,168,581
Ensembl chr 4:63,140,018...63,168,581
G
Brd2
bromodomain containing 2
affects expression
EXP
Metformin affects the expression of BRD2 mRNA
CTD
PMID:25596134
NCBI chr20:4,727,078...4,735,389
Ensembl chr20:4,728,151...4,735,388
G
Btg2
BTG anti-proliferation factor 2
affects expression decreases expression
EXP
Metformin affects the expression of BTG2 mRNA Metformin results in decreased expression of BTG2 mRNA
CTD
PMID:25596134 PMID:31324951
NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
G
Bub1b
BUB1 mitotic checkpoint serine/threonine kinase B
affects expression
ISO
Metformin affects the expression of BUB1B mRNA
CTD
PMID:35568294
NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547
G
Cacna1d
calcium voltage-gated channel subunit alpha1 D
decreases expression
EXP
Metformin results in decreased expression of CACNA1D mRNA
CTD
PMID:25596134
NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215
G
Canx
calnexin
multiple interactions
EXP
Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of CANX protein]
CTD
PMID:34801538
NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821
G
Cars1
cysteinyl-tRNA synthetase 1
increases expression
EXP
Metformin results in increased expression of CARS1 mRNA
CTD
PMID:25596134 PMID:31324951
NCBI chr 1:198,753,689...198,796,016
Ensembl chr 1:198,753,691...198,795,941
G
Casp1
caspase 1
multiple interactions
ISO EXP
[Paclitaxel co-treated with Metformin] results in increased expression of CASP1 mRNA Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased cleavage of CASP1 protein]
CTD
PMID:29309887 PMID:36999408
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
G
Casp14
caspase 14
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in increased expression of CASP14 mRNA
CTD
PMID:29309887
NCBI chr 7:10,929,759...10,932,591
Ensembl chr 7:10,926,725...10,933,405
G
Casp3
caspase 3
multiple interactions increases cleavage increases expression decreases activity increases activity
ISO EXP
[epothilone A co-treated with Metformin] results in increased expression of CASP3 mRNA; [Metformin co-treated with NVP-BKM120] results in increased cleavage of CASP3 protein; BBC3 protein promotes the reaction [[Metformin co-treated with NVP-BKM120] results in increased cleavage of CASP3 protein]; Cisplatin promotes the reaction [Metformin results in increased activity of CASP3 protein]; FOXO3 protein promotes the reaction [[Metformin co-treated with NVP-BKM120] results in increased cleavage of CASP3 protein]; Metformin inhibits the reaction [Sunitinib results in increased cleavage of CASP3 protein]; plantamajoside promotes the reaction [Metformin results in increased cleavage of CASP3 protein]; Sodium Salicylate promotes the reaction [[epothilone A co-treated with Metformin] results in increased expression of CASP3 mRNA]; Sodium Salicylate promotes the reaction [Metformin results in increased expression of CASP3 mRNA]; triciribine promotes the reaction [[epothilone A co-treated with Metformin] results in increased expression of CASP3 mRNA] Deoxyglucose promotes the reaction [Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein modified form]]; Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein modified form]; Metformin inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; SIRT3 protein promotes the reaction [Metformin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]] Metformin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 mRNA]; Metformin inhibits the reaction [Dietary Fats results in increased expression of and results in increased cleavage of CASP3 protein]; Metformin inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]; Metformin inhibits the reaction [Glucose results in increased activity of CASP3 protein]; Metformin inhibits the reaction [Glucose results in increased expression of and results in increased activity of CASP3 protein]; Metformin inhibits the reaction [Streptozocin results in increased expression of CASP3 mRNA] Metformin results in decreased activity of CASP3 protein
CTD
PMID:15531508 PMID:21388661 PMID:21906609 PMID:26818447 PMID:27551045 PMID:28106847 PMID:29095437 PMID:29117515 PMID:30144576 PMID:34649470 PMID:34801538 PMID:35199402 PMID:35350904 PMID:35414346 PMID:36800006 PMID:38479708 More...
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Casp4
caspase 4
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in increased expression of CASP4 mRNA
CTD
PMID:29309887
NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
G
Casp7
caspase 7
multiple interactions increases activity
ISO EXP
Cisplatin promotes the reaction [Metformin results in increased activity of CASP7 protein]; Metformin inhibits the reaction [Sunitinib results in increased cleavage of CASP7 protein] dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]; Metformin promotes the reaction [dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]]
CTD
PMID:21388661 PMID:21906609 PMID:30551545
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
G
Casp8
caspase 8
decreases activity multiple interactions
ISO
Metformin results in decreased activity of CASP8 protein [Paclitaxel co-treated with Metformin] results in increased expression of CASP8 mRNA
CTD
PMID:15531508 PMID:29309887
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
G
Casq1
calsequestrin 1
decreases expression
EXP
Metformin results in decreased expression of CASQ1 mRNA
CTD
PMID:31324951
NCBI chr13:84,670,648...84,680,339
Ensembl chr13:84,670,649...84,680,339
G
Cat
catalase
multiple interactions decreases activity increases activity decreases expression increases expression
EXP ISO
Metformin inhibits the reaction [[Fructose co-treated with Streptozocin] results in decreased activity of CAT protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of CAT protein]; Metformin inhibits the reaction [Doxorubicin results in decreased expression of CAT mRNA]; Metformin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; Metformin inhibits the reaction [Streptozocin results in decreased expression of CAT mRNA] Metformin results in decreased activity of CAT protein Metformin results in increased activity of CAT protein Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of CAT protein]; Metformin promotes the reaction [Carbon Tetrachloride results in increased activity of CAT protein] Metformin results in decreased expression of CAT mRNA Metformin results in increased expression of CAT mRNA
CTD
PMID:15531508 PMID:21457706 PMID:22627169 PMID:22666520 PMID:24717679 PMID:29185360 PMID:30958922 PMID:33639173 PMID:33823243 PMID:35414346 PMID:36999408 PMID:37120126 PMID:38602238 More...
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
G
Cby1
chibby 1, beta catenin antagonist
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CBY1 mRNA]
CTD
PMID:29095437
NCBI chr 7:111,216,835...111,223,305
G
Ccdc38
coiled-coil domain containing 38
increases expression
EXP
Metformin results in increased expression of CCDC38 mRNA
CTD
PMID:31324951
NCBI chr 7:28,055,883...28,129,938
Ensembl chr 7:28,059,798...28,130,441
G
Ccdc77
coiled-coil domain containing 77
increases expression
EXP
Metformin results in increased expression of CCDC77 mRNA
CTD
PMID:31324951
NCBI chr 4:153,534,184...153,566,059
Ensembl chr 4:153,534,187...153,566,545
G
Ccdc90b
coiled-coil domain containing 90B
increases expression
EXP
Metformin results in increased expression of CCDC90B mRNA
CTD
PMID:25596134
NCBI chr 1:146,632,756...146,646,314
Ensembl chr 1:146,633,036...146,647,338
G
Ccl2
C-C motif chemokine ligand 2
decreases expression multiple interactions
ISO EXP
Metformin results in decreased expression of CCL2 mRNA Metformin inhibits the reaction [AGT protein results in increased secretion of CCL2 protein]; Metformin inhibits the reaction [Folic Acid results in increased expression of CCL2 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of CCL2 mRNA] Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of CCL2 protein]; Metformin inhibits the reaction [Palmitic Acid results in increased expression of CCL2 mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]
CTD
PMID:20956498 PMID:25108154 PMID:26497364 PMID:29380373 PMID:29499335 PMID:30551545 PMID:33639173 More...
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
G
Ccl24
C-C motif chemokine ligand 24
multiple interactions
ISO
Metformin inhibits the reaction [IL13 protein results in increased expression of CCL24 mRNA]
CTD
PMID:26497364
NCBI chr12:21,100,835...21,104,832
Ensembl chr12:21,100,835...21,104,893
G
Ccl27
C-C motif chemokine ligand 27
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of CCL27A mRNA]
CTD
PMID:29095437
NCBI chr 5:56,941,402...56,948,511
Ensembl chr 5:56,941,402...56,948,506
G
Ccl7
C-C motif chemokine ligand 7
multiple interactions
ISO
Metformin inhibits the reaction [IL13 protein results in increased expression of CCL7 mRNA]
CTD
PMID:26497364
NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
G
Ccn2
cellular communication network factor 2
decreases expression
EXP
Metformin results in decreased expression of CCN2 mRNA
CTD
PMID:31324951
NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
G
Ccnb1
cyclin B1
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of CCNB1 mRNA
CTD
PMID:29309887
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
G
Ccnb2
cyclin B2
multiple interactions increases expression
ISO EXP
[Paclitaxel co-treated with Metformin] results in decreased expression of CCNB2 mRNA Metformin results in increased expression of CCNB2 mRNA
CTD
PMID:29309887 PMID:31324951
NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
G
Ccnc
cyclin C
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of CCNC mRNA
CTD
PMID:29309887
NCBI chr 5:35,266,828...35,284,943
Ensembl chr 5:35,266,823...35,296,584
G
Ccnd1
cyclin D1
multiple interactions decreases expression
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of CCND1 mRNA Metformin results in decreased expression of CCND1 protein
CTD
PMID:29226720 PMID:29309887
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
G
Ccnd2
cyclin D2
multiple interactions decreases expression
EXP ISO
Metformin inhibits the reaction [FSHB protein results in increased expression of CCND2 protein] [Paclitaxel co-treated with Metformin] results in decreased expression of CCND2 mRNA Metformin results in decreased expression of CCND2 protein
CTD
PMID:16760380 PMID:29309887
NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
G
Ccne1
cyclin E1
multiple interactions decreases expression
EXP ISO
Metformin inhibits the reaction [FSHB protein results in increased expression of CCNE1 protein] [Metformin co-treated with NVP-BKM120] results in decreased expression of CCNE1 protein; [Paclitaxel co-treated with Metformin] results in decreased expression of CCNE1 mRNA Metformin results in decreased expression of CCNE1 protein
CTD
PMID:16760380 PMID:29309887 PMID:38479708
NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
G
Ccnf
cyclin F
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of CCNF mRNA
CTD
PMID:29309887
NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101
G
Ccng1
cyclin G1
increases expression multiple interactions
EXP ISO
Metformin results in increased expression of CCNG1 mRNA [Paclitaxel co-treated with Metformin] results in decreased expression of CCNG1 mRNA
CTD
PMID:19022234 PMID:29309887
NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
G
Ccng2
cyclin G2
decreases expression multiple interactions
ISO EXP
Metformin results in decreased expression of CCNG2 mRNA [Paclitaxel co-treated with Metformin] results in decreased expression of CCNG2 mRNA
CTD
PMID:25596134 PMID:29309887
NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830
G
Ccr2
C-C motif chemokine receptor 2
multiple interactions
ISO
Metformin inhibits the reaction [IL13 protein results in increased expression of CCR2 mRNA]
CTD
PMID:26497364
NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
G
Cd14
CD14 molecule
increases expression
ISO
Metformin results in increased expression of CD14 protein
CTD
PMID:26036281
NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
G
Cd40lg
CD40 ligand
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of CD40LG mRNA
CTD
PMID:29309887
NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306
G
Cd52
CD52 molecule
decreases expression
EXP
Metformin results in decreased expression of CD52 mRNA
CTD
PMID:31324951
NCBI chr 5:146,319,789...146,321,348
Ensembl chr 5:146,319,969...146,321,348
G
Cd63
Cd63 molecule
increases expression
EXP
Metformin results in increased expression of CD63 mRNA
CTD
PMID:31324951
NCBI chr 7:1,325,108...1,340,447
Ensembl chr 7:1,325,103...1,399,178
G
Cd74
CD74 molecule
decreases expression
EXP
Metformin results in decreased expression of CD74 mRNA
CTD
PMID:31324951
NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003
G
Cdc16
cell division cycle 16
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of CDC16 mRNA
CTD
PMID:29309887
NCBI chr16:75,773,026...75,796,586
Ensembl chr16:75,773,028...75,796,550
G
Cdc20
cell division cycle 20
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of CDC20 mRNA
CTD
PMID:29309887
NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
G
Cdc25a
cell division cycle 25A
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of CDC25A mRNA
CTD
PMID:29309887
NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
G
Cdc25b
cell division cycle 25B
decreases expression
EXP
Metformin results in decreased expression of CDC25B mRNA
CTD
PMID:31324951
NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272
G
Cdc34
cell division cycle 34, ubiqiutin conjugating enzyme
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of CDC34 mRNA
CTD
PMID:29309887
NCBI chr 7:10,017,588...10,023,586
Ensembl chr 7:10,017,588...10,023,186
G
Cdc42
cell division cycle 42
decreases expression
ISO
Metformin results in decreased expression of CDC42 mRNA
CTD
PMID:32589349
NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111
G
Cdh1
cadherin 1
multiple interactions
ISO
[Metformin co-treated with NVP-BKM120] results in increased expression of CDH1 protein; Metformin inhibits the reaction [BMP2 protein results in decreased expression of CDH1 mRNA]
CTD
PMID:37409753 PMID:38479708
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
G
Cdip1
cell death-inducing p53 target 1
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CDIP1 mRNA]
CTD
PMID:29095437
NCBI chr10:10,773,538...10,796,979
Ensembl chr10:10,774,705...10,796,980
G
Cdk1
cyclin-dependent kinase 1
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of CDK1 mRNA
CTD
PMID:29309887
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
G
Cdk2
cyclin dependent kinase 2
multiple interactions
ISO
[Metformin co-treated with NVP-BKM120] results in decreased expression of CDK2 protein; [Paclitaxel co-treated with Metformin] results in decreased expression of CDK2 mRNA
CTD
PMID:29309887 PMID:38479708
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
G
Cdk4
cyclin-dependent kinase 4
multiple interactions increases expression
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of CDK4 mRNA Metformin results in increased expression of CDK4 protein
CTD
PMID:29226720 PMID:29309887
NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
G
Cdk5r1
cyclin-dependent kinase 5 regulatory subunit 1
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of CDK5R1 mRNA
CTD
PMID:29309887
NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456
G
Cdk6
cyclin-dependent kinase 6
increases expression
EXP
Metformin results in increased expression of CDK6 mRNA
CTD
PMID:25596134
NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
G
Cdk7
cyclin-dependent kinase 7
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of CDK7 mRNA
CTD
PMID:29309887
NCBI chr 2:31,840,558...31,865,422
Ensembl chr 2:31,840,558...31,865,383
G
Cdk8
cyclin-dependent kinase 8
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of CDK8 mRNA
CTD
PMID:29309887
NCBI chr12:8,737,198...8,805,026
Ensembl chr12:8,737,262...8,804,177
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression multiple interactions
EXP ISO
Metformin results in increased expression of CDKN1A mRNA [Metformin co-treated with NVP-BKM120] results in increased expression of CDKN1A protein Metformin inhibits the reaction [Testosterone results in decreased expression of CDKN1A mRNA]
CTD
PMID:25596134 PMID:26492952 PMID:31324951 PMID:38479708
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
G
Cdkn1b
cyclin-dependent kinase inhibitor 1B
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in increased expression of CDKN1B mRNA
CTD
PMID:29309887
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
G
Cebpa
CCAAT/enhancer binding protein alpha
decreases expression
EXP
Metformin results in decreased expression of CEBPA mRNA
CTD
PMID:19022234
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
G
Cers5
ceramide synthase 5
increases expression
EXP
Metformin results in increased expression of CERS5 mRNA
CTD
PMID:25596134
NCBI chr 7:130,859,993...130,897,979
Ensembl chr 7:130,859,990...130,897,947
G
Cfd
complement factor D
decreases expression
ISO
Metformin results in decreased expression of CFD mRNA
CTD
PMID:17148569
NCBI chr 7:9,813,148...9,814,871
Ensembl chr 7:9,813,150...9,815,053
G
Chek1
checkpoint kinase 1
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of CHEK1 mRNA
CTD
PMID:29309887
NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
G
Chek2
checkpoint kinase 2
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of CHEK2 mRNA
CTD
PMID:29309887
NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
G
Chuk
component of inhibitor of nuclear factor kappa B kinase complex
decreases expression multiple interactions
ISO
Metformin results in decreased expression of CHUK mRNA [Metformin co-treated with Pioglitazone] results in decreased expression of CHUK mRNA
CTD
PMID:32589349
NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
G
Cish
cytokine inducible SH2-containing protein
decreases expression
EXP
Metformin results in decreased expression of CISH mRNA
CTD
PMID:31324951
NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250
G
Ckap2
cytoskeleton associated protein 2
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CKAP2 mRNA]
CTD
PMID:29095437
NCBI chr16:69,839,668...69,864,852
Ensembl chr16:69,839,630...69,864,913
G
Cldn2
claudin 2
decreases expression
ISO
Metformin results in decreased expression of CLDN2 protein
CTD
PMID:37121296
NCBI chr X:103,459,870...103,473,794
Ensembl chr X:103,459,780...103,474,838
G
Cldn3
claudin 3
decreases expression
EXP
Metformin results in decreased expression of CLDN3 mRNA
CTD
PMID:31324951
NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001
G
Cmbl
carboxymethylenebutenolidase homolog
decreases expression
EXP
Metformin results in decreased expression of CMBL mRNA
CTD
PMID:25596134
NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:82,571,888...82,591,009
G
Cnppd1
cyclin Pas1/PHO80 domain containing 1
decreases expression
EXP
Metformin results in decreased expression of CNPPD1 mRNA
CTD
PMID:31324951
NCBI chr 9:76,633,475...76,640,164
Ensembl chr 9:76,633,477...76,640,188
G
Col4a1
collagen type IV alpha 1 chain
multiple interactions
ISO
Metformin inhibits the reaction [Folic Acid results in increased expression of COL4A1 mRNA]
CTD
PMID:29380373
NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412
G
Cpt1a
carnitine palmitoyltransferase 1A
decreases expression affects expression
EXP
Metformin results in decreased expression of CPT1A mRNA Metformin affects the expression of CPT1A mRNA
CTD
PMID:19022234 PMID:31324951
NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
G
Cptp
ceramide-1-phosphate transfer protein
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CPTP mRNA]
CTD
PMID:29095437
NCBI chr 5:166,474,947...166,479,103
Ensembl chr 5:166,474,966...166,479,017
G
Creb1
cAMP responsive element binding protein 1
multiple interactions
EXP
Metformin inhibits the reaction [Methamphetamine results in decreased expression of and results in decreased phosphorylation of CREB1 protein]
CTD
PMID:30742852
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
G
Creb3l2
cAMP responsive element binding protein 3-like 2
multiple interactions increases expression
ISO EXP
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CREB3L2 mRNA] Metformin results in increased expression of CREB3L2 mRNA
CTD
PMID:29095437 PMID:31324951
NCBI chr 4:65,907,570...66,112,078
Ensembl chr 4:65,907,655...66,023,763
G
Crebrf
CREB3 regulatory factor
decreases expression
EXP
Metformin results in decreased expression of CREBRF mRNA
CTD
PMID:31324951
NCBI chr10:16,399,170...16,479,650
Ensembl chr10:16,404,596...16,461,999
G
Creld2
cysteine-rich with EGF-like domains 2
increases expression
EXP
Metformin results in increased expression of CRELD2 mRNA
CTD
PMID:31324951
NCBI chr 7:119,909,626...119,916,556
Ensembl chr 7:119,909,633...119,916,543
G
Crot
carnitine O-octanoyltransferase
increases expression
EXP
Metformin results in increased expression of CROT mRNA
CTD
PMID:31324951
NCBI chr 4:25,068,270...25,133,111
Ensembl chr 4:25,080,587...25,133,109
G
Crp
C-reactive protein
decreases expression multiple interactions
ISO EXP
Metformin results in decreased expression of CRP protein Metformin inhibits the reaction [Fructose results in increased expression of CRP protein]
CTD
PMID:14557435 PMID:25108154
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
G
Cst3
cystatin C
multiple interactions
EXP
Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CST3 protein]
CTD
PMID:30551545
NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822
G
Ctdp1
CTD phosphatase subunit 1
increases expression
EXP
Metformin results in increased expression of CTDP1 mRNA
CTD
PMID:25596134
NCBI chr18:73,854,277...73,916,232
Ensembl chr18:73,854,282...73,916,457
G
Ctdsp2
CTD small phosphatase 2
decreases expression
EXP
Metformin results in decreased expression of CTDSP2 mRNA
CTD
PMID:31324951
NCBI chr 7:62,805,398...62,825,306
Ensembl chr 7:62,805,658...62,825,302
G
Cth
cystathionine gamma-lyase
decreases expression
EXP
Metformin results in decreased expression of CTH mRNA
CTD
PMID:25596134
NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
G
Ctnnb1
catenin beta 1
decreases expression
ISO
Metformin results in decreased expression of CTNNB1 protein
CTD
PMID:34432352
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
G
Ctsc
cathepsin C
decreases expression
EXP
Metformin results in decreased expression of CTSC mRNA
CTD
PMID:25596134
NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387
G
Cttn
cortactin
increases expression
EXP
Metformin results in increased expression of CTTN mRNA
CTD
PMID:25596134
NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164
G
Cttnbp2nl
CTTNBP2 N-terminal like
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of CTTNBP2NL mRNA]
CTD
PMID:29095437
NCBI chr 2:192,507,963...192,554,548
Ensembl chr 2:192,507,963...192,541,101
G
Cxcl1
C-X-C motif chemokine ligand 1
affects expression multiple interactions
EXP
Metformin affects the expression of CXCL1 mRNA Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin] inhibits the reaction [Ovalbumin results in increased expression of CXCL1 protein]]
CTD
PMID:31324951 PMID:36547818
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
G
Cxcl13
C-X-C motif chemokine ligand 13
decreases expression
EXP
Metformin results in decreased expression of CXCL13 mRNA
CTD
PMID:31324951
NCBI chr14:13,608,894...13,613,965
Ensembl chr14:13,608,902...13,613,933
G
Cxcl2
C-X-C motif chemokine ligand 2
multiple interactions
ISO
Metformin inhibits the reaction [IL13 protein results in increased expression of CXCL2 mRNA]
CTD
PMID:26497364
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
G
Cxcl9
C-X-C motif chemokine ligand 9
decreases expression
EXP
Metformin results in decreased expression of CXCL9 mRNA
CTD
PMID:31324951
NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435
G
Cyba
cytochrome b-245 alpha chain
decreases expression multiple interactions
ISO EXP
Metformin results in decreased expression of CYBA mRNA Metformin affects the reaction [Dehydroepiandrosterone results in increased expression of CYBA protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of CYBA mRNA]
CTD
PMID:15531508 PMID:27634381
NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
G
Cybb
cytochrome b-245 beta chain
multiple interactions
EXP ISO
Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of CYBB protein] Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of NOX2 mRNA]
CTD
PMID:35085591 PMID:37120126
NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
G
Cycs
cytochrome c, somatic
multiple interactions
EXP ISO
Metformin inhibits the reaction [Streptozocin results in increased expression of CYCS mRNA] Metformin inhibits the reaction [Doxorubicin results in increased secretion of CYCS protein]; Metformin inhibits the reaction [Streptozocin affects the localization of CYCS protein]
CTD
PMID:34649470 PMID:35414346 PMID:37453608
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
G
Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
multiple interactions
EXP
Metformin inhibits the reaction [FSHB protein results in increased expression of CYP11A1 protein]
CTD
PMID:16760380
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
G
Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
decreases expression multiple interactions affects expression
ISO EXP
Metformin results in decreased expression of CYP17A1 mRNA Metformin inhibits the reaction [Letrozole results in increased expression of CYP17A1 mRNA] Metformin affects the expression of CYP17A1 mRNA
CTD
PMID:23166782 PMID:31324951 PMID:32298659
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
G
Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
multiple interactions
EXP
Metformin inhibits the reaction [FSHB protein results in increased expression of CYP19A1 protein]
CTD
PMID:16760380
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions decreases expression increases expression
ISO EXP
Metformin promotes the reaction [Streptozocin results in increased expression of CYP1A1 mRNA] Metformin results in decreased expression of CYP1A1 mRNA Metformin results in decreased expression of CYP1A1 mRNA; Metformin results in decreased expression of CYP1A1 protein Metformin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of and results in increased activity of CYP1A1 protein]; Metformin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 mRNA]; Metformin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein] Metformin results in increased expression of CYP1A1 mRNA
CTD
PMID:22342832 PMID:25110054 PMID:25596134 PMID:25697376
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases expression decreases expression
ISO EXP
Metformin results in increased expression of CYP1A2 mRNA Metformin results in decreased expression of CYP1A2 mRNA
CTD
PMID:19022234 PMID:25596134
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
G
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
multiple interactions decreases expression
ISO
Metformin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 protein] Metformin results in decreased expression of CYP1B1 mRNA; Metformin results in decreased expression of CYP1B1 protein
CTD
PMID:25110054
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
G
Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
decreases expression multiple interactions
ISO
Metformin results in decreased expression of CYP27A1 mRNA [Ethinyl Estradiol co-treated with Metformin] results in decreased expression of CYP27A1 mRNA; [Metformin co-treated with Ethinyl Estradiol] results in decreased expression of CYP27A1 protein
CTD
PMID:34058177
NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
G
Cyp27b1
cytochrome P450, family 27, subfamily b, polypeptide 1
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in increased expression of CYP27B1 mRNA
CTD
PMID:29309887
NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241
G
Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
increases expression
ISO
Metformin results in increased expression of CYP2B10 mRNA
CTD
PMID:22342832
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
G
Cyp2c12
cytochrome P450, family 2, subfamily c, polypeptide 12
increases expression
EXP
Metformin results in increased expression of CYP2C12 mRNA
CTD
PMID:31324951
NCBI chr 1:238,699,859...238,757,011
Ensembl chr 1:238,699,854...238,757,019
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
increases expression
ISO
Metformin results in increased expression of CYP2E1 mRNA
CTD
PMID:22342832
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases expression decreases expression multiple interactions
ISO
Metformin results in increased expression of CYP3A4 mRNA Metformin results in decreased expression of CYP3A4 mRNA Metformin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; Metformin inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein]
CTD
PMID:19022234 PMID:21920351
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
G
Cyp7a1
cytochrome P450 family 7 subfamily A member 1
multiple interactions increases expression affects expression
EXP ISO
Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP7A1 mRNA]; Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP7A1 protein] Metformin results in increased expression of CYP7A1 protein [Ethinyl Estradiol co-treated with Metformin] results in decreased expression of CYP7A1 mRNA; [Metformin co-treated with Ethinyl Estradiol] results in decreased expression of CYP7A1 protein Metformin affects the expression of CYP7A1 mRNA
CTD
PMID:31100278 PMID:31324951 PMID:34058177
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
G
Cyp7b1
cytochrome P450 family 7 subfamily B member 1
multiple interactions
ISO
[Ethinyl Estradiol co-treated with Metformin] results in decreased expression of CYP7B1 mRNA
CTD
PMID:34058177
NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698
G
Cyp8b1
cytochrome P450 family 8 subfamily B member 1
increases expression decreases expression multiple interactions
EXP ISO
Metformin results in increased expression of CYP8B1 mRNA Metformin results in decreased expression of CYP8B1 protein [Ethinyl Estradiol co-treated with Metformin] results in decreased expression of CYP8B1 mRNA; [Metformin co-treated with Ethinyl Estradiol] results in decreased expression of CYP8B1 protein
CTD
PMID:31324951 PMID:34058177
NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
G
Dapk1
death associated protein kinase 1
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in increased expression of DAPK1 mRNA
CTD
PMID:29309887
NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991
G
Dcxr
dicarbonyl and L-xylulose reductase
decreases expression
EXP
Metformin results in decreased expression of DCXR mRNA
CTD
PMID:31324951
NCBI chr10:106,006,404...106,008,293
G
Ddhd1
DDHD domain containing 1
increases expression
EXP
Metformin results in increased expression of DDHD1 mRNA
CTD
PMID:31324951
NCBI chr15:18,824,389...18,891,036
Ensembl chr15:18,824,394...18,890,952
G
Ddi2
DNA damage inducible 1 homolog 2
decreases expression
EXP
Metformin results in decreased expression of DDI2 mRNA
CTD
PMID:31324951
NCBI chr 5:153,989,591...154,035,342
Ensembl chr 5:153,995,589...154,035,283
G
Ddit3
DNA-damage inducible transcript 3
increases expression multiple interactions
EXP ISO
Metformin results in increased expression of DDIT3 mRNA Metformin inhibits the reaction [INS protein results in increased expression of DDIT3 protein] Metformin inhibits the reaction [Glucose results in increased expression of DDIT3 protein] Metformin inhibits the reaction [Rotenone results in increased expression of DDIT3 mRNA]
CTD
PMID:25596134 PMID:32189544 PMID:34801538 PMID:36764371
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
G
Ddit4
DNA-damage-inducible transcript 4
decreases expression multiple interactions increases expression
EXP ISO
Metformin results in decreased expression of DDIT4 mRNA [Metformin co-treated with Pioglitazone] results in increased expression of DDIT4 mRNA Metformin results in increased expression of DDIT4 mRNA
CTD
PMID:25596134 PMID:32589349
NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
G
Ddit4l
DNA-damage-inducible transcript 4-like
multiple interactions
ISO
[Metformin co-treated with Pioglitazone] results in increased expression of DDIT4L mRNA
CTD
PMID:32589349
NCBI chr 2:226,128,273...226,131,044
Ensembl chr 2:226,128,276...226,131,375
G
Ddx17
DEAD-box helicase 17
increases expression
EXP
Metformin results in increased expression of DDX17 mRNA
CTD
PMID:25596134
NCBI chr 7:111,091,127...111,109,353
Ensembl chr 7:111,089,445...111,109,193
G
Ddx24
DEAD-box helicase 24
increases expression
EXP
Metformin results in increased expression of DDX24 mRNA
CTD
PMID:25596134
NCBI chr 6:122,564,767...122,582,032
Ensembl chr 6:122,564,767...122,581,927
G
Denr
density regulated reinitiation and release factor
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of DENR mRNA]
CTD
PMID:29095437
NCBI chr12:32,662,512...32,685,283
Ensembl chr12:32,662,516...32,683,843
G
Deptor
DEP domain containing MTOR-interacting protein
multiple interactions decreases expression
ISO
[Metformin co-treated with Pioglitazone] results in decreased expression of DEPTOR mRNA Metformin results in decreased expression of DEPTOR mRNA
CTD
PMID:32589349
NCBI chr 7:86,514,859...86,668,817
Ensembl chr 7:86,514,988...86,667,773
G
Dffa
DNA fragmentation factor subunit alpha
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of DFFA mRNA
CTD
PMID:29309887
NCBI chr 5:159,540,715...159,553,639
Ensembl chr 5:159,540,715...159,553,633
G
Dgat2
diacylglycerol O-acyltransferase 2
multiple interactions
ISO
Metformin inhibits the reaction [INS protein results in increased activity of DGAT2 protein]
CTD
PMID:36764371
NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428
G
Dgka
diacylglycerol kinase, alpha
increases expression
EXP
Metformin results in increased expression of DGKA mRNA
CTD
PMID:25596134
NCBI chr 7:1,148,734...1,175,324
Ensembl chr 7:1,148,735...1,175,110
G
Dhx37
DEAH-box helicase 37
increases expression
EXP
Metformin results in increased expression of DHX37 mRNA
CTD
PMID:25596134
NCBI chr12:31,194,782...31,214,890
Ensembl chr12:31,194,859...31,216,802
G
Dhx9
DExH-box helicase 9
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of DHX9 mRNA]
CTD
PMID:29095437
NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069
G
Diablo
diablo, IAP-binding mitochondrial protein
multiple interactions
ISO
Metformin inhibits the reaction [Acetaminophen affects the localization of DIABLO protein]
CTD
PMID:27562556
NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387
G
Dlat
dihydrolipoamide S-acetyltransferase
increases expression
EXP
Metformin results in increased expression of DLAT mRNA
CTD
PMID:31324951
NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479
G
Dlgap5
DLG associated protein 5
increases expression
EXP
Metformin results in increased expression of DLGAP5 mRNA
CTD
PMID:25596134
NCBI chr15:20,633,964...20,664,569
Ensembl chr15:20,633,966...20,664,518
G
Dmbt1
deleted in malignant brain tumors 1
increases expression
EXP
Metformin results in increased expression of DMBT1 mRNA
CTD
PMID:31324951
NCBI chr 1:185,617,469...185,696,476
Ensembl chr 1:185,617,294...185,696,478
G
Dmxl2
Dmx-like 2
decreases expression
EXP
Metformin results in decreased expression of DMXL2 mRNA
CTD
PMID:31324951
NCBI chr 8:54,741,164...54,884,948
Ensembl chr 8:54,741,160...54,885,161
G
Dnajb9
DnaJ heat shock protein family (Hsp40) member B9
increases expression
EXP
Metformin results in increased expression of DNAJB9 mRNA
CTD
PMID:25596134
NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063
G
Dnm1l
dynamin 1-like
multiple interactions
EXP
Metformin inhibits the reaction [Glucose results in increased expression of DNM1L protein]
CTD
PMID:30144576
NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
G
Dnmbp
dynamin binding protein
decreases expression
EXP
Metformin results in decreased expression of DNMBP mRNA
CTD
PMID:25596134
NCBI chr 1:242,736,189...242,829,431
Ensembl chr 1:242,736,189...242,802,604
G
Dnmt1
DNA methyltransferase 1
multiple interactions
EXP
Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin] inhibits the reaction [Ovalbumin results in decreased expression of DNMT1 mRNA]]; Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin] inhibits the reaction [Ovalbumin results in decreased expression of DNMT1 protein]]
CTD
PMID:36547818
NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
G
Dpep1
dipeptidase 1
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of DPEP1 mRNA]
CTD
PMID:29095437
NCBI chr19:51,209,831...51,237,004
Ensembl chr19:51,219,660...51,235,257
G
Dpp9
dipeptidyl peptidase 9
decreases expression
EXP
Metformin results in decreased expression of DPP9 mRNA
CTD
PMID:25596134
NCBI chr 9:1,011,347...1,046,337
Ensembl chr 9:1,011,351...1,046,541
G
Dusp1
dual specificity phosphatase 1
decreases expression
EXP
Metformin results in decreased expression of DUSP1 mRNA
CTD
PMID:31324951
NCBI chr10:16,680,478...16,683,275
G
Dusp22
dual specificity phosphatase 22
decreases expression
EXP
Metformin results in decreased expression of DUSP22 mRNA
CTD
PMID:25596134
NCBI chr17:33,780,980...33,831,241
Ensembl chr17:33,780,981...33,831,321
G
Dusp4
dual specificity phosphatase 4
increases expression
EXP
Metformin results in increased expression of DUSP4 mRNA
CTD
PMID:19664596
NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138
G
Dusp5
dual specificity phosphatase 5
increases expression
EXP ISO
Metformin results in increased expression of DUSP5 mRNA
CTD
PMID:25596134
NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818
G
E2f4
E2F transcription factor 4
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of E2F4 mRNA
CTD
PMID:29309887
NCBI chr19:33,174,396...33,181,806
Ensembl chr19:33,174,410...33,181,806
G
Ebi3
Epstein-Barr virus induced 3
multiple interactions decreases expression
EXP ISO
Metformin co-treated with metformin hydrochloride co-treated with N(gamma)-nitro-L-arginine methyl ester inhibits the reaction [pre-eclampsia increases expression of Ebi3 mRNA in peripheral blood] Metformin decreases expression of Ebi3 mRNA in umbilical vein endothelial cells
RGD
PMID:31203154 PMID:31203154
RGD:213230155 , RGD:213230155
NCBI chr 9:774,252...787,544
Ensembl chr 9:783,617...787,544
G
Ech1
enoyl-CoA hydratase 1
increases expression
EXP
Metformin results in increased expression of ECH1 mRNA
CTD
PMID:31324951
NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
G
Eci1
enoyl-CoA delta isomerase 1
increases expression
EXP
Metformin results in increased expression of ECI1 mRNA
CTD
PMID:31324951
NCBI chr10:13,456,715...13,470,061
Ensembl chr10:13,456,563...13,470,061
G
Eda2r
ectodysplasin A2 receptor
increases expression multiple interactions
EXP ISO
Metformin results in increased expression of EDA2R mRNA Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of EDA2R mRNA]
CTD
PMID:25596134 PMID:29095437
NCBI chr X:62,224,763...62,269,333
Ensembl chr X:62,228,229...62,269,268
G
Edn1
endothelin 1
multiple interactions
EXP ISO
Metformin inhibits the reaction [Fructose results in increased expression of EDN1 protein] Metformin inhibits the reaction [IL13 protein results in increased expression of EDN1 mRNA]
CTD
PMID:25108154 PMID:26497364
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
G
Efna1
ephrin A1
decreases expression
EXP
Metformin results in decreased expression of EFNA1 mRNA
CTD
PMID:25596134
NCBI chr 2:174,681,676...174,689,061
Ensembl chr 2:174,681,682...174,690,866
G
Egr1
early growth response 1
increases expression
EXP
Metformin results in increased expression of EGR1 mRNA
CTD
PMID:19664596 PMID:31324951
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
G
Eif1
eukaryotic translation initiation factor 1
increases expression
EXP
Metformin results in increased expression of EIF1 mRNA
CTD
PMID:25596134
NCBI chr10:85,246,751...85,248,842
Ensembl chr10:85,246,764...85,427,327
G
Eif2ak3
eukaryotic translation initiation factor 2 alpha kinase 3
multiple interactions
EXP ISO
Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of EIF2AK3 protein]; Metformin inhibits the reaction [Glucose results in increased phosphorylation of EIF2AK3 protein] Metformin inhibits the reaction [INS protein results in increased phosphorylation of EIF2AK3 protein]
CTD
PMID:34801538 PMID:36764371
NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
G
Eif2s1
eukaryotic translation initiation factor 2 subunit alpha
multiple interactions
EXP ISO
Metformin inhibits the reaction [Glucose results in increased phosphorylation of EIF2S1 protein] Metformin inhibits the reaction [INS protein results in increased phosphorylation of EIF2S1 protein]
CTD
PMID:34801538 PMID:36764371
NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
G
Eif2s2
eukaryotic translation initiation factor 2 subunit beta
increases expression
EXP
Metformin results in increased expression of EIF2S2 mRNA
CTD
PMID:25596134
NCBI chr 3:143,374,652...143,395,460
Ensembl chr 3:143,373,686...143,395,432
G
Eif3c
eukaryotic translation initiation factor 3, subunit C
increases expression
EXP
Metformin results in increased expression of EIF3C mRNA
CTD
PMID:25596134
NCBI chr 1:181,134,604...181,152,489
Ensembl chr 1:181,134,604...181,152,493
G
Eif4e
eukaryotic translation initiation factor 4E
decreases expression multiple interactions
ISO
Metformin results in decreased expression of EIF4E mRNA [Metformin co-treated with Pioglitazone] results in decreased expression of EIF4E mRNA
CTD
PMID:32589349
NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
G
Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
decreases phosphorylation multiple interactions
ISO
Metformin results in decreased phosphorylation of EIF4EBP1 protein Metformin decreases phosphorylation of EIF4EBP1 protein in epithelial cell of alveolus of lung Metformin results in decreased phosphorylation of and results in increased expression of EIF4EBP1 protein
CTD RGD
PMID:22108913 PMID:23363784 PMID:23632475
RGD:150404268
NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
G
Elf4
E74 like ETS transcription factor 4
increases expression
EXP
Metformin results in increased expression of ELF4 mRNA
CTD
PMID:25596134
NCBI chr X:127,587,401...127,639,063
Ensembl chr X:127,590,650...127,630,200
G
Elk4
ETS transcription factor ELK4
increases expression
ISO
Metformin results in increased expression of ELK4 mRNA
CTD
PMID:25596134
NCBI chr13:43,451,130...43,475,035
Ensembl chr13:43,435,843...43,475,035
G
Elovl6
ELOVL fatty acid elongase 6
decreases expression affects expression
ISO EXP
Metformin results in decreased expression of ELOVL6 protein Metformin affects the expression of ELOVL6 mRNA
CTD
PMID:28576465 PMID:31324951
NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186
G
Emb
embigin
decreases expression
EXP
Metformin results in decreased expression of EMB mRNA
CTD
PMID:31324951
NCBI chr 2:49,070,509...49,125,042
Ensembl chr 2:49,069,087...49,125,050
G
Eno2
enolase 2
increases expression
EXP
Metformin results in increased expression of ENO2 mRNA
CTD
PMID:25596134
NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980
G
Entpd7
ectonucleoside triphosphate diphosphohydrolase 7
increases expression
EXP
Metformin results in increased expression of ENTPD7 mRNA
CTD
PMID:31324951
NCBI chr 1:242,559,365...242,601,044
Ensembl chr 1:242,559,365...242,601,447
G
Ep400
E1A binding protein p400
affects expression
EXP
Metformin affects the expression of EP400 mRNA
CTD
PMID:25596134
NCBI chr12:45,891,886...46,002,523
Ensembl chr12:45,891,916...45,998,861
G
Eprs1
glutamyl-prolyl-tRNA synthetase 1
increases expression
EXP
Metformin results in increased expression of EPRS1 mRNA
CTD
PMID:25596134
NCBI chr13:96,901,548...96,971,966
Ensembl chr13:96,901,575...96,971,966
G
Eqtn
equatorin
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of EQTN mRNA]
CTD
PMID:29095437
NCBI chr 5:109,734,495...109,762,048
Ensembl chr 5:109,728,999...109,761,840
G
Erbb3
erb-b2 receptor tyrosine kinase 3
decreases expression
EXP
Metformin results in decreased expression of ERBB3 mRNA
CTD
PMID:31324951
NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525
G
Ern1
endoplasmic reticulum to nucleus signaling 1
multiple interactions
EXP ISO
Metformin inhibits the reaction [Glucose results in increased phosphorylation of ERN1 protein] Metformin inhibits the reaction [INS protein results in increased phosphorylation of ERN1 protein]
CTD
PMID:34801538 PMID:36764371
NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
G
Ero1a
endoplasmic reticulum oxidoreductase 1 alpha
multiple interactions
EXP
Metformin inhibits the reaction [Glucose results in increased expression of ERO1A protein]
CTD
PMID:34801538
NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478
G
Esr1
estrogen receptor 1
multiple interactions
ISO EXP
Metformin binds to and results in decreased activity of ESR1 protein; Metformin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to POU5F1 promoter]]; Metformin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to POU5F1 promoter]] Metformin inhibits the reaction [Testosterone results in increased expression of ESR1 mRNA]
CTD
PMID:22132214 PMID:26492952 PMID:33049310
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
G
Esr2
estrogen receptor 2
multiple interactions
EXP
Metformin inhibits the reaction [Testosterone results in decreased expression of ESR2 mRNA]
CTD
PMID:26492952
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
G
Esrra
estrogen related receptor, alpha
multiple interactions decreases expression
ISO
Metformin inhibits the reaction [GCG protein results in increased expression of ESRRA mRNA] Metformin results in decreased expression of ESRRA mRNA
CTD
PMID:23166782
NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268
G
Faap20
FA core complex associated protein 20
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of FAAP20 mRNA]
CTD
PMID:29095437
NCBI chr 5:165,808,370...165,815,291
Ensembl chr 5:165,808,657...165,815,333
G
Fabp2
fatty acid binding protein 2
decreases expression
EXP
Metformin results in decreased expression of FABP2 mRNA
CTD
PMID:19022234
NCBI chr 2:211,040,032...211,044,089
Ensembl chr 2:211,040,032...211,044,089
G
Fabp3
fatty acid binding protein 3
increases expression
EXP
Metformin results in increased expression of FABP3 mRNA
CTD
PMID:25596134
NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718
G
Fabp7
fatty acid binding protein 7
increases expression
EXP
Metformin results in increased expression of FABP7 mRNA
CTD
PMID:31324951
NCBI chr20:37,123,193...37,126,725
Ensembl chr20:37,123,193...37,126,880
G
Fam149a
family with sequence similarity 149, member A
decreases expression
EXP
Metformin results in decreased expression of FAM149A mRNA
CTD
PMID:31324951
NCBI chr16:46,855,377...46,914,553
Ensembl chr16:46,854,635...46,912,066
G
Fam210a
family with sequence similarity 210, member A
increases expression
EXP
Metformin results in increased expression of FAM210A mRNA
CTD
PMID:25596134
NCBI chr18:61,846,447...61,886,123
Ensembl chr18:61,852,907...61,886,171
G
Fam32a
family with sequence similarity 32, member A
decreases expression
EXP
Metformin results in decreased expression of FAM32A mRNA
CTD
PMID:25596134
NCBI chr16:17,603,054...17,607,376
Ensembl chr16:17,603,946...17,607,398
G
Fas
Fas cell surface death receptor
affects expression
EXP
Metformin affects the expression of FAS mRNA
CTD
PMID:25596134
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
G
Fasn
fatty acid synthase
decreases expression increases expression multiple interactions
ISO EXP
Metformin results in decreased expression of FASN mRNA Metformin results in increased expression of FASN mRNA [Metformin co-treated with caffeic acid] results in decreased expression of FASN protein; Metformin inhibits the reaction [[cyhalothrin co-treated with Oleic Acid] results in increased expression of FASN protein]; Metformin inhibits the reaction [INS protein results in increased expression of FASN protein]
CTD
PMID:20956498 PMID:21870829 PMID:28576465 PMID:31324951 PMID:36529352 PMID:36764371 More...
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
G
Fbp1
fructose-bisphosphatase 1
decreases expression
EXP
Metformin results in decreased expression of FBP1 mRNA
CTD
PMID:19022234
NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071
G
Fbxo22
F-box protein 22
increases expression
EXP
Metformin results in increased expression of FBXO22 mRNA
CTD
PMID:25596134
NCBI chr 8:55,579,906...55,595,981
Ensembl chr 8:55,579,891...55,596,148
G
Fbxo30
F-box protein 30
increases expression
EXP
Metformin results in increased expression of FBXO30 mRNA
CTD
PMID:25596134
NCBI chr 1:5,655,341...5,671,558
Ensembl chr 1:5,655,339...5,672,441
G
Fbxo32
F-box protein 32
decreases expression
EXP
Metformin results in decreased expression of FBXO32 mRNA
CTD
PMID:31324951
NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436
G
Fech
ferrochelatase
decreases expression
EXP
Metformin results in decreased expression of FECH mRNA
CTD
PMID:25596134
NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348
G
Fgf1
fibroblast growth factor 1
multiple interactions
ISO
Metformin inhibits the reaction [IL13 protein results in increased expression of FGF1 mRNA]
CTD
PMID:26497364
NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
G
Fgf19
fibroblast growth factor 19
multiple interactions
ISO
[Ethinyl Estradiol co-treated with Metformin] results in decreased expression of FGF15 mRNA
CTD
PMID:34058177
NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287
G
Fgf21
fibroblast growth factor 21
multiple interactions
ISO
Metformin inhibits the reaction [INS protein results in decreased expression of FGF21 protein]
CTD
PMID:36764371
NCBI chr 1:96,083,360...96,084,911
Ensembl chr 1:96,083,441...96,090,454
G
Fgr
FGR proto-oncogene, Src family tyrosine kinase
decreases expression
EXP
Metformin results in decreased expression of FGR mRNA
CTD
PMID:25596134
NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326
G
Ficd
FIC domain protein adenylyltransferase
increases expression
EXP
Metformin results in increased expression of FICD mRNA
CTD
PMID:31324951
NCBI chr12:42,889,195...42,894,090
Ensembl chr12:42,889,194...42,894,070
G
Fis1
fission, mitochondrial 1
multiple interactions
EXP
Metformin inhibits the reaction [Glucose results in increased expression of FIS1 protein]
CTD
PMID:30144576
NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377
G
Fkbp1a
FKBP prolyl isomerase 1A
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in increased expression of FKBP1A mRNA
CTD
PMID:29309887
NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743
G
Flvcr2
FLVCR choline and putative heme transporter 2
increases expression
EXP
Metformin results in increased expression of FLVCR2 mRNA
CTD
PMID:25596134 PMID:31324951
NCBI chr 6:105,408,355...105,472,355
Ensembl chr 6:105,408,339...105,472,353
G
Fmo3
flavin containing dimethylaniline monoxygenase 3
decreases expression
EXP
Metformin results in decreased expression of FMO3 mRNA
CTD
PMID:31324951
NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028
G
Fn1
fibronectin 1
multiple interactions
EXP ISO
Metformin inhibits the reaction [Dietary Fats results in increased expression of FN1 protein] Metformin inhibits the reaction [Folic Acid results in increased expression of FN1 mRNA]; Metformin inhibits the reaction [Folic Acid results in increased expression of FN1 protein]
CTD
PMID:27551045 PMID:29380373
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
G
Fndc5
fibronectin type III domain containing 5
multiple interactions
ISO
Metformin inhibits the reaction [Dietary Fats results in decreased expression of FNDC5 mRNA]; Metformin inhibits the reaction [Dietary Fats results in decreased expression of FNDC5 protein]
CTD
PMID:36375515
NCBI chr 5:141,481,593...141,491,257
Ensembl chr 5:141,481,590...141,490,731
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions decreases expression
ISO EXP
Metformin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of FOS protein] Metformin results in decreased expression of FOS mRNA
CTD
PMID:20590612 PMID:31324951
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
G
Foxa2
forkhead box A2
multiple interactions
ISO
[Metformin co-treated with Glucose] affects the localization of FOXA2 protein
CTD
PMID:16489446
NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326
G
Foxo1
forkhead box O1
decreases expression multiple interactions
ISO EXP
Metformin results in decreased expression of FOXO1 mRNA Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] affects the localization of FOXO1 protein]
CTD
PMID:24428821 PMID:27270450
NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
G
Foxo3
forkhead box O3
decreases expression multiple interactions
EXP ISO
Metformin results in decreased expression of FOXO3 mRNA FOXO3 protein promotes the reaction [[Metformin co-treated with NVP-BKM120] results in increased cleavage of CASP3 protein]; FOXO3 protein promotes the reaction [[Metformin co-treated with NVP-BKM120] results in increased expression of BBC3 protein]
CTD
PMID:31324951 PMID:38479708
NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
G
Fshb
follicle stimulating hormone subunit beta
multiple interactions
EXP
Metformin inhibits the reaction [FSHB protein results in increased expression of CCND2 protein]; Metformin inhibits the reaction [FSHB protein results in increased expression of CCNE1 protein]; Metformin inhibits the reaction [FSHB protein results in increased expression of CYP11A1 protein]; Metformin inhibits the reaction [FSHB protein results in increased expression of CYP19A1 protein]; Metformin inhibits the reaction [FSHB protein results in increased expression of HSD3B protein]; Metformin inhibits the reaction [FSHB protein results in increased expression of STAR protein]; Metformin inhibits the reaction [FSHB protein results in increased secretion of Estradiol]; Metformin inhibits the reaction [FSHB protein results in increased secretion of Progesterone]; PRKAA1 gene mutant form inhibits the reaction [Metformin inhibits the reaction [FSHB protein results in increased expression of HSD3B protein]]; PRKAA1 gene mutant form inhibits the reaction [Metformin inhibits the reaction [FSHB protein results in increased expression of STAR protein]]; PRKAA1 gene mutant form inhibits the reaction [Metformin promotes the reaction [FSHB protein results in increased phosphorylation of PRKAA1 protein]]
CTD
PMID:16760380
NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
G
Fut4
fucosyltransferase 4
increases expression
ISO
Metformin results in increased expression of FUT4 protein
CTD
PMID:26036281
NCBI chr 8:11,586,721...11,590,682
Ensembl chr 8:11,586,721...11,590,682
G
G0s2
G0/G1switch 2
increases expression
EXP
Metformin results in increased expression of G0S2 mRNA
CTD
PMID:31324951
NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451
G
G6pc1
glucose-6-phosphatase catalytic subunit 1
multiple interactions decreases expression
EXP ISO
Metformin inhibits the reaction [Glucose results in increased expression of G6PC1 mRNA] Metformin results in decreased expression of G6PC1 mRNA Metformin inhibits the reaction [INS protein results in increased expression of G6PC1 protein]
CTD
PMID:19576170 PMID:19664596 PMID:24428821 PMID:31324951 PMID:31974165 PMID:33651899 More...
NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
G
G6pd
glucose-6-phosphate dehydrogenase
increases expression
EXP
Metformin results in increased expression of G6PD mRNA
CTD
PMID:31324951
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
G
Gad1
glutamate decarboxylase 1
multiple interactions
EXP
Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of GAD1 protein]
CTD
PMID:35085591
NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
G
Gadd45a
growth arrest and DNA-damage-inducible, alpha
increases expression
ISO EXP
Metformin results in increased expression of GADD45A mRNA
CTD
PMID:19022234 PMID:25596134
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
G
Gars1
glycyl-tRNA synthetase 1
increases expression
EXP
Metformin results in increased expression of GARS1 mRNA
CTD
PMID:25596134
NCBI chr 4:84,171,596...84,212,609
Ensembl chr 4:84,171,596...84,212,609
G
Gbe1
1,4-alpha-glucan branching enzyme 1
increases expression
EXP
Metformin results in increased expression of GBE1 mRNA
CTD
PMID:25596134
NCBI chr11:8,734,806...9,000,226
Ensembl chr11:8,734,820...9,000,210
G
Gbp1
guanylate binding protein 1
decreases expression
EXP
Metformin results in decreased expression of GBP1 mRNA
CTD
PMID:31324951
NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131 Ensembl chr 2:231,398,163...231,432,131
G
Gbp1-ps1
guanylate binding protein 1, pseudogene 1
decreases expression
EXP
Metformin results in decreased expression of GBP1-PS1 mRNA
CTD
PMID:31324951
NCBI chr 2:231,517,485...231,525,865
Ensembl chr 2:231,517,398...231,529,600
G
Gcg
glucagon
multiple interactions
EXP ISO
Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of GCG protein]; Metformin inhibits the reaction [GCG results in increased abundance of Glucose] [Metformin co-treated with GCG] results in increased expression of IL1RN mRNA; Metformin inhibits the reaction [GCG protein results in increased expression of ESRRA mRNA]; Metformin inhibits the reaction [GCG protein results in increased expression of PPARGC1A mRNA]; Metformin inhibits the reaction [GCG protein results in increased expression of SIRT3 mRNA]; Metformin promotes the reaction [GCG protein results in decreased expression of IL15RA mRNA]
CTD
PMID:19002567 PMID:22117073 PMID:23166782 PMID:27270450
NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929
G
Gck
glucokinase
affects expression multiple interactions
EXP ISO
Metformin affects the expression of GCK mRNA Metformin inhibits the reaction [INS protein results in decreased activity of GCK protein]; Metformin inhibits the reaction [INS protein results in decreased expression of GCK protein] Metformin inhibits the reaction [Glucose results in decreased expression of GCK mRNA]
CTD
PMID:31324951 PMID:31974165 PMID:33651899
NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
G
Gckr
glucokinase regulator
multiple interactions
ISO
Metformin inhibits the reaction [INS protein results in increased expression of GCKR protein]
CTD
PMID:33651899
NCBI chr 6:25,044,592...25,075,834
Ensembl chr 6:25,045,100...25,075,654
G
Gclc
glutamate-cysteine ligase, catalytic subunit
increases expression
EXP
Metformin results in increased expression of GCLC mRNA
CTD
PMID:25596134
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
G
Gclm
glutamate cysteine ligase, modifier subunit
decreases expression increases expression
EXP ISO
Metformin results in decreased expression of GCLM mRNA Metformin results in increased expression of GCLM mRNA
CTD
PMID:25596134 PMID:33838154
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
G
Gcnt3
glucosaminyl (N-acetyl) transferase 3, mucin type
increases expression multiple interactions
ISO EXP
Metformin results in increased expression of GCNT3 mRNA Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of GCNT3 mRNA]
CTD
PMID:25596134 PMID:29095437
NCBI chr 8:70,689,173...70,696,476
Ensembl chr 8:70,686,844...70,699,562
G
Gdf15
growth differentiation factor 15
increases expression
EXP
Metformin results in increased expression of GDF15 mRNA
CTD
PMID:25596134
NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
G
Gfap
glial fibrillary acidic protein
multiple interactions
ISO
Metformin inhibits the reaction [Olanzapine results in increased expression of GFAP mRNA]
CTD
PMID:32652086
NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
G
Ghrl
ghrelin and obestatin prepropeptide
multiple interactions
ISO
Metformin inhibits the reaction [Olanzapine results in increased expression of GHRL protein]
CTD
PMID:32652086
NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621
G
Ghsr
growth hormone secretagogue receptor
multiple interactions
ISO
Metformin inhibits the reaction [Olanzapine results in increased expression of GHSR mRNA]
CTD
PMID:32652086
NCBI chr 2:110,268,489...110,271,865
Ensembl chr 2:110,268,489...110,271,865
G
Gimd1
GIMAP family P-loop NTPase domain containing 1
increases expression
EXP
Metformin results in increased expression of GIMD1 mRNA
CTD
PMID:31324951
NCBI chr 2:221,103,878...221,138,559
Ensembl chr 2:221,103,878...221,138,553
G
Gls
glutaminase
decreases expression
ISO
Metformin results in decreased expression of GLS protein
CTD
PMID:28576465
NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900
G
Gmppb
GDP-mannose pyrophosphorylase B
increases expression
EXP
Metformin results in increased expression of GMPPB mRNA
CTD
PMID:31324951
NCBI chr 8:108,737,429...108,740,437
Ensembl chr 8:108,693,060...108,767,286
G
Gmpr
guanosine monophosphate reductase
decreases expression
ISO
Metformin results in decreased expression of GMPR mRNA
CTD
PMID:23457588
NCBI chr17:19,151,820...19,189,626
Ensembl chr17:19,151,815...19,189,621
G
Gnmt
glycine N-methyltransferase
decreases expression
EXP
Metformin results in decreased expression of GNMT mRNA
CTD
PMID:31324951
NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434
G
Golph3l
golgi phosphoprotein 3-like
increases expression
EXP
Metformin results in increased expression of GOLPH3L mRNA
CTD
PMID:31324951
NCBI chr 2:183,151,941...183,183,094
Ensembl chr 2:183,153,301...183,183,083
G
Golph3l-ps1
golgi phosphoprotein 3-like, pseudogene 1
increases expression
EXP
Metformin results in increased expression of GOLPH3L-PS1 mRNA
CTD
PMID:31324951
NCBI chr 9:45,890,492...45,891,363
G
Got1
glutamic-oxaloacetic transaminase 1
decreases expression multiple interactions
EXP ISO
Metformin results in decreased expression of GOT1 mRNA Metformin inhibits the reaction [Doxorubicin results in increased activity of GOT1 protein]
CTD
PMID:25596134 PMID:31324951 PMID:38364893
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
G
Gpam
glycerol-3-phosphate acyltransferase, mitochondrial
increases expression
EXP
Metformin results in increased expression of GPAM mRNA
CTD
PMID:31324951
NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
G
Gpat3
glycerol-3-phosphate acyltransferase 3
increases expression
ISO
Metformin results in increased expression of GPAT3 mRNA
CTD
PMID:25596134
NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490
G
Gpd1l2
glycerol-3-phosphate dehydrogenase 1 like 2
increases expression
EXP
Metformin results in increased expression of GPD1L2 mRNA
CTD
PMID:31324951
NCBI chr 7:91,940,258...91,942,125
Ensembl chr 7:91,940,260...91,942,559
G
Gphn
gephyrin
increases expression
EXP
Metformin results in increased expression of GPHN mRNA
CTD
PMID:25596134
NCBI chr 6:96,954,365...97,483,617
Ensembl chr 6:96,892,148...97,483,612
G
Gpihbp1
glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
increases expression
EXP
Metformin results in increased expression of GPIHBP1 mRNA
CTD
PMID:31324951
NCBI chr 7:107,285,584...107,288,702
Ensembl chr 7:107,285,654...107,288,702
G
Gpnmb
glycoprotein nmb
increases expression
EXP
Metformin results in increased expression of GPNMB mRNA
CTD
PMID:25596134
NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367
G
Gpr22
G protein-coupled receptor 22
decreases expression
EXP
Metformin results in decreased expression of GPR22 mRNA
CTD
PMID:31324951
NCBI chr 6:48,309,619...48,317,864
Ensembl chr 6:48,310,505...48,317,486
G
Gprin3
GPRIN family member 3
increases expression
EXP
Metformin results in increased expression of GPRIN3 mRNA
CTD
PMID:31324951
NCBI chr 4:88,572,062...88,657,369
Ensembl chr 4:88,563,607...88,657,429
G
Gpt
glutamic--pyruvic transaminase
multiple interactions
ISO EXP
Metformin inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in increased expression of GPT protein]; Metformin inhibits the reaction [Acetaminophen results in increased expression of and results in increased secretion of and results in increased activity of GPT protein]; Metformin inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; Metformin inhibits the reaction [Doxorubicin results in increased activity of GPT protein]; Metformin inhibits the reaction [Doxorubicin results in increased secretion of GPT protein] Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased activity of GPT protein]
CTD
PMID:24717679 PMID:27562556 PMID:29614383 PMID:31743741 PMID:38364893
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
G
Gsk3a
glycogen synthase kinase 3 alpha
increases phosphorylation
ISO
Metformin results in increased phosphorylation of GSK3A protein
CTD
PMID:26835874
NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802
G
Gsk3b
glycogen synthase kinase 3 beta
increases phosphorylation multiple interactions decreases expression
ISO EXP
Metformin results in increased phosphorylation of GSK3B protein Metformin inhibits the reaction [Streptozocin results in decreased phosphorylation of GSK3B protein] Metformin results in decreased expression of GSK3B protein modified form Metformin inhibits the reaction [[Streptozocin co-treated with Coconut Oil co-treated with Cholesterol] results in decreased phosphorylation of GSK3B protein]; Metformin inhibits the reaction [Methamphetamine results in increased expression of and results in increased phosphorylation of GSK3B protein] AKT1 protein modified form inhibits the reaction [Metformin promotes the reaction [plantamajoside results in decreased phosphorylation of GSK3B protein]]; Metformin inhibits the reaction [cyanoginosin LR results in increased phosphorylation of GSK3B protein]; Metformin inhibits the reaction [INS protein results in decreased phosphorylation of GSK3B protein]; Metformin inhibits the reaction [INS protein results in increased expression of GSK3B protein]; Metformin promotes the reaction [plantamajoside results in decreased phosphorylation of GSK3B protein]
CTD
PMID:21054339 PMID:26835874 PMID:30742852 PMID:30928401 PMID:31877369 PMID:33651899 PMID:33838154 PMID:34432352 PMID:34649470 PMID:35350904 More...
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
G
Gsn
gelsolin
increases expression
ISO
Metformin results in increased expression of GSN mRNA
CTD
PMID:19022234
NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
G
Gspt1
G1 to S phase transition 1
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of GSPT1 mRNA]
CTD
PMID:29095437
NCBI chr10:4,362,528...4,397,215
Ensembl chr10:4,362,510...4,397,198
G
Gsr
glutathione-disulfide reductase
multiple interactions affects expression
ISO EXP
Metformin inhibits the reaction [Carbon Tetrachloride results in decreased activity of GSR protein] Metformin inhibits the reaction [Methamphetamine results in decreased activity of GSR protein]; Metformin inhibits the reaction [Streptozocin results in decreased activity of GSR protein] Metformin affects the expression of GSR mRNA
CTD
PMID:24717679 PMID:25596134 PMID:30742852 PMID:35414346
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
G
Gsta1
glutathione S-transferase alpha 1
multiple interactions
EXP
Metformin inhibits the reaction [Doxorubicin results in increased expression of GSTA1 mRNA]
CTD
PMID:22666520
NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
G
Gstm2
glutathione S-transferase mu 2
decreases expression
EXP
Metformin results in decreased expression of GSTM2 mRNA
CTD
PMID:31324951
NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
G
Gstp1
glutathione S-transferase pi 1
increases expression
EXP
Metformin results in increased expression of GSTP1 mRNA
CTD
PMID:19022234
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
G
Gypa
glycophorin A
decreases expression
EXP
Metformin results in decreased expression of GYPA mRNA
CTD
PMID:31324951
NCBI chr19:27,450,304...27,465,940
Ensembl chr19:27,450,308...27,465,822
G
Gys1
glycogen synthase 1
multiple interactions
ISO
Metformin inhibits the reaction [INS protein results in decreased expression of GYS1 protein]
CTD
PMID:33651899
NCBI chr 1:95,915,443...95,935,292
Ensembl chr 1:95,915,443...95,935,292
G
H19
H19 imprinted maternally expressed transcript
increases methylation multiple interactions decreases expression
ISO EXP
Metformin increases methylation of H19 RNA in umbilical vein endothelial cells Metformin co-treated with metformin hydrochloride co-treated with N(gamma)-nitro-L-arginine methyl ester inhibits the reaction [pre-eclampsia increases expression of H19 RNA in peripheral blood] Metformin decreases expression of H19 RNA in umbilical vein endothelial cells
RGD
PMID:31203154 PMID:31203154 PMID:31203154
RGD:213230155 , RGD:213230155 , RGD:213230155
NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134
G
H1f2
H1.2 linker histone, cluster member
decreases expression
ISO
Metformin results in decreased expression of H1-2 mRNA
CTD
PMID:25596134
NCBI chr17:41,391,106...41,392,597
Ensembl chr17:41,388,477...41,392,635
G
H2ax
H2A.X variant histone
decreases expression increases expression multiple interactions
ISO
Metformin results in decreased expression of H2AX protein Metformin results in increased expression of H2AX mRNA [epothilone A co-treated with Metformin] results in increased expression of H2AX mRNA
CTD
PMID:23363784 PMID:29117515
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
G
Hal
histidine ammonia lyase
decreases expression
EXP
Metformin results in decreased expression of HAL mRNA
CTD
PMID:31324951
NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701
G
Hamp
hepcidin antimicrobial peptide
decreases expression
EXP
Metformin results in decreased expression of HAMP mRNA
CTD
PMID:31324951
NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
G
Havcr1
hepatitis A virus cellular receptor 1
multiple interactions
EXP
dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]; Metformin promotes the reaction [dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]]
CTD
PMID:30551545
NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
G
Hbb
hemoglobin subunit beta
decreases expression
EXP
Metformin results in decreased expression of HBB-B1 mRNA
CTD
PMID:31324951
NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012
G
Heatr6
HEAT repeat containing 6
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of HEATR6 mRNA]
CTD
PMID:29095437
NCBI chr10:68,635,048...68,665,445
Ensembl chr10:68,635,065...68,664,105
G
Hemgn
hemogen
decreases expression
EXP
Metformin results in decreased expression of HEMGN mRNA
CTD
PMID:31324951
NCBI chr 5:60,679,633...60,698,597
Ensembl chr 5:60,679,633...60,698,669
G
Herc3
HECT and RLD domain containing E3 ubiquitin protein ligase 3
decreases expression
EXP
Metformin results in decreased expression of HERC3 mRNA
CTD
PMID:25596134
NCBI chr 4:87,952,202...88,042,492
Ensembl chr 4:87,952,274...88,042,488
G
Herpud1
homocysteine inducible ER protein with ubiquitin like domain 1
increases expression
EXP
Metformin results in increased expression of HERPUD1 mRNA
CTD
PMID:31324951
NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424
G
Hhex
hematopoietically expressed homeobox
decreases expression
EXP
Metformin results in decreased expression of HHEX mRNA
CTD
PMID:31324951
NCBI chr 1:235,190,455...235,196,042
Ensembl chr 1:235,190,455...235,196,042
G
Hif1a
hypoxia inducible factor 1 subunit alpha
affects activity multiple interactions decreases expression
EXP ISO
Metformin affects the activity of HIF1A protein [Metformin co-treated with Pioglitazone] results in decreased expression of HIF1A mRNA Metformin results in decreased expression of HIF1A mRNA
CTD
PMID:25596134 PMID:32589349
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
G
Hist2h3c2
histone cluster 2 H3 family member C2
increases expression
EXP
Metformin results in increased expression of HIST2H3C2 mRNA
CTD
PMID:31324951
NCBI chr 2:183,837,296...183,837,721
Ensembl chr 2:183,837,303...183,837,752
G
Hmgb1
high mobility group box 1
multiple interactions
ISO
[Simvastatin co-treated with Metformin] results in increased secretion of HMGB1 protein; necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] results in increased secretion of HMGB1 protein]
CTD
PMID:25412314
NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565 Ensembl chr16:5,901,586...5,978,565
G
Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
decreases expression increases expression multiple interactions
ISO EXP
Metformin results in decreased expression of HMGCR mRNA Metformin results in increased expression of HMGCR mRNA Metformin inhibits the reaction [AGT protein results in increased activity of and results in increased phosphorylation of HMGCR protein]
CTD
PMID:21870829 PMID:29499335 PMID:31324951
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
G
Hmox1
heme oxygenase 1
increases expression decreases expression multiple interactions decreases response to substance
ISO EXP
Metformin results in increased expression of HMOX1 mRNA Metformin results in decreased expression of HMOX1 mRNA; Metformin results in decreased expression of HMOX1 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Metformin results in decreased expression of HMOX1 protein] HMOX1 protein results in decreased susceptibility to Metformin Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]; Metformin inhibits the reaction [Doxorubicin results in increased expression of HMOX1 mRNA]; Metformin inhibits the reaction [Streptozocin results in decreased expression of HMOX1 mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of HMOX1 mRNA]
CTD
PMID:19022234 PMID:21457706 PMID:22666520 PMID:23707609 PMID:25596134 PMID:33639173 PMID:33838154 PMID:36999408 More...
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
G
Hnf4a
hepatocyte nuclear factor 4, alpha
decreases expression
EXP ISO
Metformin results in decreased expression of HNF4A mRNA Metformin results in decreased expression of HNF4A mRNA; Metformin results in decreased expression of HNF4A protein
CTD
PMID:19022234 PMID:24428821
NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
G
Hnrnpk
heterogeneous nuclear ribonucleoprotein K
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of HNRNPK mRNA
CTD
PMID:29309887
NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997
G
Hook2
hook microtubule-tethering protein 2
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of HOOK2 mRNA]
CTD
PMID:29095437
NCBI chr19:23,151,869...23,170,139
Ensembl chr19:23,151,870...23,164,181
G
Hras
HRas proto-oncogene, GTPase
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of HRAS mRNA
CTD
PMID:29309887
NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
G
Hrh2
histamine receptor H 2
multiple interactions
ISO
[Cimetidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Metformin; [Famotidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Metformin; [Ranitidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Metformin
CTD
PMID:16632449
NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631
G
Hsc70-ps1
heat shock cognate protein 70, pseudogene 1
increases expression
EXP
Metformin results in increased expression of HSC70-PS1 mRNA
CTD
PMID:31324951
NCBI chr 2:164,044,226...164,046,344
Ensembl chr 2:164,044,261...164,046,336
G
Hsc70-ps2
heat shock cognate protein 70, pseudogene 2
increases expression
EXP
Metformin results in increased expression of HSC70-PS2 mRNA
CTD
PMID:31324951
NCBI chr18:16,210,467...16,212,736
Ensembl chr18:16,210,531...16,212,635
G
Hspa5
heat shock protein family A (Hsp70) member 5
increases expression multiple interactions
EXP ISO
Metformin results in increased expression of HSPA5 mRNA Metformin inhibits the reaction [INS protein results in increased expression of HSPA5 protein] Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of HSPA5 protein]; Metformin inhibits the reaction [Glucose results in increased expression of HSPA5 protein] Metformin inhibits the reaction [Rotenone results in increased expression of HSPA5 mRNA]
CTD
PMID:25596134 PMID:32189544 PMID:34801538 PMID:36764371
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
G
Hspa9
heat shock protein family A (Hsp70) member 9
multiple interactions
ISO
Metformin inhibits the reaction [INS protein results in decreased expression of HSPA9 protein]
CTD
PMID:36764371
NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
G
Hsph1
heat shock protein family H (Hsp110) member 1
increases expression
EXP
Metformin results in increased expression of HSPH1 mRNA
CTD
PMID:31324951
NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224
G
Htatip2
HIV-1 Tat interactive protein 2
increases expression
EXP
Metformin results in increased expression of HTATIP2 mRNA
CTD
PMID:25596134
NCBI chr 1:99,473,411...99,488,632
Ensembl chr 1:99,469,245...99,488,629
G
Htr1a
5-hydroxytryptamine receptor 1A
multiple interactions
EXP
Metformin inhibits the reaction [Chlorpyrifos results in increased expression of HTR1A mRNA]
CTD
PMID:35448458
NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442
G
Htr2a
5-hydroxytryptamine receptor 2A
multiple interactions
EXP
Metformin inhibits the reaction [Chlorpyrifos results in increased expression of HTR2A mRNA]
CTD
PMID:35448458
NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
G
Hykk
hydroxylysine kinase
decreases expression
EXP
Metformin results in decreased expression of HYKK mRNA
CTD
PMID:31324951
NCBI chr 8:55,315,919...55,339,720
Ensembl chr 8:55,315,969...55,337,339
G
Hyou1
hypoxia up-regulated 1
increases expression
EXP
Metformin results in increased expression of HYOU1 mRNA
CTD
PMID:31324951
NCBI chr 8:44,706,073...44,718,189
Ensembl chr 8:44,706,263...44,718,186
G
Iars1
isoleucyl-tRNA synthetase 1
increases expression
EXP
Metformin results in increased expression of IARS1 mRNA
CTD
PMID:25596134 PMID:31324951
NCBI chr17:14,940,919...14,987,277
Ensembl chr17:14,940,924...14,987,237
G
Icam1
intercellular adhesion molecule 1
multiple interactions
EXP
Metformin inhibits the reaction [Fructose results in increased expression of ICAM1 protein modified form]
CTD
PMID:25108154
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
G
Ide
insulin degrading enzyme
multiple interactions
ISO
Metformin inhibits the reaction [INS protein results in decreased expression of IDE protein]
CTD
PMID:36764371
NCBI chr 1:235,002,984...235,102,448
Ensembl chr 1:234,995,351...235,102,440
G
Idi1
isopentenyl-diphosphate delta isomerase 1
increases expression
EXP
Metformin results in increased expression of IDI1 mRNA
CTD
PMID:31324951
NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
G
Ifgga4l
interferon-gamma-inducible GTPase 4 like
decreases expression
EXP
Metformin results in decreased expression of IFGGA4L mRNA
CTD
PMID:31324951
NCBI chr18:53,838,426...53,854,858
Ensembl chr18:53,851,449...53,852,696
G
Ifitm3
interferon induced transmembrane protein 3
decreases expression
EXP
Metformin results in decreased expression of IFITM3 mRNA
CTD
PMID:31324951
NCBI chr 1:196,111,026...196,112,135
Ensembl chr 1:196,111,043...196,112,203
G
Ifna1
interferon, alpha 1
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in increased expression of IFNA1 mRNA
CTD
PMID:29309887
NCBI chr 5:103,097,356...103,097,925
Ensembl chr 5:103,097,356...103,097,925
G
Ifng
interferon gamma
increases expression multiple interactions
ISO
Metformin results in increased expression of IFNG protein [Paclitaxel co-treated with Metformin] results in increased expression of IFNG mRNA
CTD
PMID:20869956 PMID:29309887
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
G
Igf1
insulin-like growth factor 1
multiple interactions
ISO EXP
[Metformin co-treated with IGF1 protein] results in decreased expression of IGF1R mRNA; [Metformin co-treated with IGF1 protein] results in decreased expression of IGF2R mRNA; [Metformin co-treated with IGF1 protein] results in decreased expression of INSR mRNA; [Metformin co-treated with IGF1 protein] results in increased phosphorylation of AKT1 protein; [Metformin co-treated with Pioglitazone] results in decreased expression of IGF1 mRNA Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IGF1 protein]; Metformin inhibits the reaction [Testosterone results in increased expression of IGF1 mRNA] Metformin inhibits the reaction [IL13 protein results in increased expression of IGF1 mRNA]; Metformin inhibits the reaction [Streptozocin results in decreased expression of IGF1 protein]
CTD
PMID:21664031 PMID:23927877 PMID:26492952 PMID:26497364 PMID:32589349 PMID:36999408 More...
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
G
Igf1r
insulin-like growth factor 1 receptor
multiple interactions
ISO EXP
[Metformin co-treated with IGF1 protein] results in decreased expression of IGF1R mRNA; [Metformin co-treated with IGF2 protein] results in decreased expression of IGF1R mRNA; [Metformin co-treated with INS protein] results in decreased expression of IGF1R mRNA Metformin inhibits the reaction [Testosterone results in increased expression of IGF1R mRNA]; Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin co-treated with Ovalbumin] results in decreased expression of IGF1R mRNA]; Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin co-treated with Ovalbumin] results in decreased expression of IGF1R protein]
CTD
PMID:21664031 PMID:26492952 PMID:36547818
NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777
G
Igf2
insulin-like growth factor 2
multiple interactions
ISO
[Metformin co-treated with IGF2 protein] results in decreased expression of IGF1R mRNA; [Metformin co-treated with IGF2 protein] results in decreased expression of IGF2R mRNA; [Metformin co-treated with IGF2 protein] results in decreased expression of INSR mRNA; [Metformin co-treated with IGF2 protein] results in increased phosphorylation of AKT1 protein
CTD
PMID:21664031
NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
G
Igf2r
insulin-like growth factor 2 receptor
multiple interactions increases expression
ISO EXP
[Metformin co-treated with IGF1 protein] results in decreased expression of IGF2R mRNA; [Metformin co-treated with IGF2 protein] results in decreased expression of IGF2R mRNA; [Metformin co-treated with INS protein] results in decreased expression of IGF2R mRNA Metformin results in increased expression of IGF2R mRNA
CTD
PMID:21664031 PMID:25596134
NCBI chr 1:47,979,109...48,067,501
Ensembl chr 1:47,979,109...48,067,501
G
Igfbp1
insulin-like growth factor binding protein 1
decreases expression
ISO EXP
Metformin results in decreased expression of IGFBP1 mRNA
CTD
PMID:21316309 PMID:31324951
NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
G
Ikbkb
inhibitor of nuclear factor kappa B kinase subunit beta
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of IKBKB mRNA
CTD
PMID:29309887
NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
G
Il10
interleukin 10
multiple interactions
EXP ISO
Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of IL10 protein]; Metformin inhibits the reaction [Streptozocin results in decreased expression of IL10 protein] Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of IL10 mRNA]; Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of IL10 protein]
CTD
PMID:33639173 PMID:35085591 PMID:37120126
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
G
Il13
interleukin 13
multiple interactions
ISO
Metformin inhibits the reaction [IL13 protein results in increased expression of ARG1 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of CCL2 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of CCL24 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of CCL7 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of CCR2 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of CHIL3 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of CXCL2 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of EDN1 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of FGF1 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of IGF1 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of IL1B mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of MGL2 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of MMP10 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of MMP14 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of MMP9 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of MRC1 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of MRC1 protein]; Metformin inhibits the reaction [IL13 protein results in increased expression of PPARG mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of RETNLA mRNA]
CTD
PMID:26497364
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
G
Il15ra
interleukin 15 receptor subunit alpha
multiple interactions decreases expression
ISO
[Metformin co-treated with Cyclic AMP] results in decreased expression of IL15RA mRNA; Metformin promotes the reaction [GCG protein results in decreased expression of IL15RA mRNA] Metformin results in decreased expression of IL15RA mRNA
CTD
PMID:22117073
NCBI chr17:66,802,300...66,831,973
Ensembl chr17:66,802,334...66,832,278
G
Il17rb
interleukin 17 receptor B
decreases expression
EXP
Metformin results in decreased expression of IL17RB mRNA
CTD
PMID:25596134
NCBI chr16:5,180,431...5,194,125
Ensembl chr16:5,180,432...5,194,125
G
Il1b
interleukin 1 beta
multiple interactions increases expression
ISO EXP
Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK10 protein]; Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]; Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK9 protein]; Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of RELA protein]; Metformin inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; Metformin inhibits the reaction [IL1B protein results in increased secretion of IL6 protein] Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IL1B protein]; Metformin inhibits the reaction [Chlorpyrifos results in increased expression of IL1B protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of IL1B protein]; Metformin inhibits the reaction [Dietary Fats results in increased expression of IL1B protein]; Metformin inhibits the reaction [Methamphetamine results in increased expression of IL1B protein]; Metformin inhibits the reaction [Streptozocin results in decreased expression of IL1B protein]; Metformin inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA]; Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin] inhibits the reaction [Ovalbumin results in increased expression of IL1B protein]] Metformin inhibits the reaction [IL13 protein results in increased expression of IL1B mRNA]; Metformin inhibits the reaction [Rotenone results in increased expression of IL1B mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of IL1B protein] Metformin results in increased expression of IL1B mRNA
CTD
PMID:16385087 PMID:21316309 PMID:26497364 PMID:27551045 PMID:27634381 PMID:28259689 PMID:30742852 PMID:32189544 PMID:33639173 PMID:35085591 PMID:35448458 PMID:36547818 More...
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il1rn
interleukin 1 receptor antagonist
multiple interactions increases expression
ISO
[Metformin co-treated with GCG] results in increased expression of IL1RN mRNA; Cyclic AMP promotes the reaction [Metformin results in increased expression of IL1RN mRNA]; Metformin promotes the reaction [Cyclic AMP results in increased expression of IL1RN mRNA]
CTD
PMID:22117073
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
G
Il33
interleukin 33
decreases expression
EXP
Metformin results in decreased expression of IL33 mRNA
CTD
PMID:31324951
NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
G
Il6
interleukin 6
decreases expression multiple interactions increases expression
ISO EXP
Metformin results in decreased expression of IL6 mRNA Metformin co-treated with metformin hydrochloride co-treated with N(gamma)-nitro-L-arginine methyl ester inhibits the reaction [pre-eclampsia increases expression of Il6 protein in blood serum] Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IL6 protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of IL6 protein]; Metformin inhibits the reaction [Fructose results in increased expression of IL6 protein]; Metformin inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of IL6 protein]; Metformin inhibits the reaction [Isoproterenol results in increased expression of IL6 mRNA]; Metformin inhibits the reaction [Palmitic Acid results in increased expression of IL6 mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of IL6 protein] 3-benzyl-5-((2-nitrophenoxy)methyl)dihydrofuran-2(3H)-one inhibits the reaction [Metformin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]]; dorsomorphin inhibits the reaction [Metformin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]]; Metformin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]; Metformin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]; Metformin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Metformin inhibits the reaction [Olanzapine results in increased expression of IL6 protein] Metformin results in increased expression of IL6 mRNA; Metformin results in increased expression of IL6 protein Metformin inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]
CTD RGD
PMID:16385087 PMID:20869956 PMID:20956498 PMID:21457706 PMID:21870829 PMID:24717679 PMID:24842192 PMID:25108154 PMID:27634381 PMID:28096963 PMID:29859833 PMID:32652086 PMID:33639173 PMID:35085591 PMID:31203154 More...
RGD:213230155
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Inmt
indolethylamine N-methyltransferase
decreases expression
EXP
Metformin results in decreased expression of INMT mRNA
CTD
PMID:31324951
NCBI chr 4:84,318,197...84,322,493
Ensembl chr 4:84,318,197...84,322,493
G
Ins1
insulin 1
multiple interactions increases secretion
EXP ISO
Metformin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased secretion of INS1 protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Coconut Oil co-treated with Cholesterol] results in increased expression of INS1 protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of INS1 protein]; Metformin inhibits the reaction [Fructose results in increased secretion of INS1 protein]; Metformin inhibits the reaction [Glucose results in increased secretion of INS1 protein]; Metformin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein] Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of INS1 protein] Metformin results in increased secretion of INS1 protein
CTD
PMID:22627169 PMID:27634381 PMID:29991592 PMID:30256492 PMID:31877369 PMID:35072544 PMID:35199402 PMID:35414346 PMID:37337224 More...
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
G
Ins2
insulin 2
multiple interactions increases expression decreases expression
ISO
[Metformin co-treated with INS protein] results in decreased expression of IGF1R mRNA; [Metformin co-treated with INS protein] results in decreased expression of IGF2R mRNA; [Metformin co-treated with INS protein] results in decreased expression of INSR mRNA; [Metformin co-treated with INS protein] results in increased phosphorylation of AKT1 protein; Metformin inhibits the reaction [[Glucose affects the susceptibility to INS protein] which affects the uptake of Glucose]; Metformin inhibits the reaction [INS protein results in decreased activity of GCK protein]; Metformin inhibits the reaction [INS protein results in decreased expression of ATP6 protein]; Metformin inhibits the reaction [INS protein results in decreased expression of BAD protein]; Metformin inhibits the reaction [INS protein results in decreased expression of FGF21 protein]; Metformin inhibits the reaction [INS protein results in decreased expression of GCK protein]; Metformin inhibits the reaction [INS protein results in decreased expression of GYS1 protein]; Metformin inhibits the reaction [INS protein results in decreased expression of HSPA9 protein]; Metformin inhibits the reaction [INS protein results in decreased expression of IDE protein]; Metformin inhibits the reaction [INS protein results in decreased expression of IRS1 protein]; Metformin inhibits the reaction [INS protein results in decreased expression of IRS2 protein]; Metformin inhibits the reaction [INS protein results in decreased expression of MFN2 protein]; Metformin inhibits the reaction [INS protein results in decreased expression of SLC2A2 protein]; Metformin inhibits the reaction [INS protein results in decreased expression of SLC2A4 protein]; Metformin inhibits the reaction [INS protein results in decreased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [INS protein results in decreased phosphorylation of GSK3B protein]; Metformin inhibits the reaction [INS protein results in decreased phosphorylation of IRS1 protein]; Metformin inhibits the reaction [INS protein results in decreased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]; Metformin inhibits the reaction [INS protein results in increased activity of DGAT2 protein]; Metformin inhibits the reaction [INS protein results in increased expression of DDIT3 protein]; Metformin inhibits the reaction [INS protein results in increased expression of FASN protein]; Metformin inhibits the reaction [INS protein results in increased expression of G6PC1 protein]; Metformin inhibits the reaction [INS protein results in increased expression of GCKR protein]; Metformin inhibits the reaction [INS protein results in increased expression of GSK3B protein]; Metformin inhibits the reaction [INS protein results in increased expression of HSPA5 protein]; Metformin inhibits the reaction [INS protein results in increased expression of IRS1 protein]; Metformin inhibits the reaction [INS protein results in increased expression of ITPR1 protein]; Metformin inhibits the reaction [INS protein results in increased expression of MAPK8 protein]; Metformin inhibits the reaction [INS protein results in increased expression of PPARG protein]; Metformin inhibits the reaction [INS protein results in increased expression of PRKCB protein]; Metformin inhibits the reaction [INS protein results in increased expression of PTPN1 protein]; Metformin inhibits the reaction [INS protein results in increased expression of SCD protein]; Metformin inhibits the reaction [INS protein results in increased expression of SREBF1 protein]; Metformin inhibits the reaction [INS protein results in increased expression of XBP1 protein]; Metformin inhibits the reaction [INS protein results in increased phosphorylation of ACACA protein]; Metformin inhibits the reaction [INS protein results in increased phosphorylation of EIF2AK3 protein]; Metformin inhibits the reaction [INS protein results in increased phosphorylation of EIF2S1 protein]; Metformin inhibits the reaction [INS protein results in increased phosphorylation of ERN1 protein]; Metformin promotes the reaction [Glucose results in increased secretion of INS protein]; Metformin results in decreased expression of and results in decreased secretion of INS protein; Metformin results in increased expression of and results in increased secretion of INS protein Metformin results in increased expression of INS mRNA Metformin results in decreased expression of INS protein
CTD
PMID:1900072 PMID:15531508 PMID:18082302 PMID:21664031 PMID:21779873 PMID:30914352 PMID:30928401 PMID:33651899 PMID:36764371 More...
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
G
Insig1
insulin induced gene 1
increases expression
ISO
Metformin results in increased expression of INSIG1 mRNA
CTD
PMID:23457588
NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
G
Insig2
insulin induced gene 2
decreases expression
EXP
Metformin results in decreased expression of INSIG2 mRNA
CTD
PMID:25596134
NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923
G
Insr
insulin receptor
multiple interactions increases phosphorylation
ISO EXP
[Metformin co-treated with IGF1 protein] results in decreased expression of INSR mRNA; [Metformin co-treated with IGF2 protein] results in decreased expression of INSR mRNA; [Metformin co-treated with INS protein] results in decreased expression of INSR mRNA Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin co-treated with Ovalbumin] results in decreased expression of INSR mRNA]; Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin co-treated with Ovalbumin] results in decreased expression of INSR protein] Metformin results in increased phosphorylation of INSR protein Metformin inhibits the reaction [Streptozocin results in decreased expression of INSR mRNA]
CTD
PMID:21664031 PMID:23927877 PMID:26835874 PMID:36547818
NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
G
Irf2bp2
interferon regulatory factor 2 binding protein 2
decreases expression
EXP
Metformin results in decreased expression of IRF2BP2 mRNA
CTD
PMID:31324951
NCBI chr19:54,559,417...54,565,096
Ensembl chr19:54,560,128...54,566,642
G
Irf3
interferon regulatory factor 3
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of IRF3 mRNA
CTD
PMID:29309887
NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
G
Irf5
interferon regulatory factor 5
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in increased expression of IRF5 mRNA
CTD
PMID:29309887
NCBI chr 4:58,127,577...58,140,665
Ensembl chr 4:58,127,640...58,139,267
G
Irf7
interferon regulatory factor 7
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in increased expression of IRF7 mRNA
CTD
PMID:29309887
NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
G
Irs1
insulin receptor substrate 1
multiple interactions
ISO EXP
Metformin affects the reaction [Testosterone results in decreased expression of IRS1]; Metformin inhibits the reaction [INS protein results in decreased expression of IRS1 protein]; Metformin inhibits the reaction [INS protein results in decreased phosphorylation of IRS1 protein]; Metformin inhibits the reaction [INS protein results in increased expression of IRS1 protein] Metformin inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of IRS1 protein] Metformin inhibits the reaction [Streptozocin results in decreased expression of IRS1 protein]; Metformin promotes the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of IRS1 protein]
CTD
PMID:19328476 PMID:23927877 PMID:27634381 PMID:30914352 PMID:30928401 PMID:31743741 PMID:36764371 More...
NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
G
Irs2
insulin receptor substrate 2
decreases expression multiple interactions
EXP ISO
Metformin results in decreased expression of IRS2 mRNA Metformin inhibits the reaction [Dietary Fats results in decreased expression of IRS2 protein] Metformin inhibits the reaction [INS protein results in decreased expression of IRS2 protein]; Metformin inhibits the reaction [Oleic Acid results in decreased expression of IRS2 protein]
CTD
PMID:31324951 PMID:36592823 PMID:36764371
NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482
G
Iscu
iron-sulfur cluster assembly enzyme
affects expression
EXP
Metformin affects the expression of ISCU mRNA
CTD
PMID:25596134
NCBI chr12:42,852,305...42,858,150
Ensembl chr12:42,852,305...42,858,150
G
Itgb1
integrin subunit beta 1
increases expression
EXP
Metformin results in increased expression of ITGB1 mRNA
CTD
PMID:25596134
NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
G
Itgb8
integrin subunit beta 8
increases expression
EXP
Metformin results in increased expression of ITGB8 mRNA
CTD
PMID:31324951
NCBI chr 6:140,125,002...140,208,261
Ensembl chr 6:140,127,203...140,208,476
G
Itpr1
inositol 1,4,5-trisphosphate receptor, type 1
multiple interactions
ISO
Metformin inhibits the reaction [INS protein results in increased expression of ITPR1 protein]
CTD
PMID:36764371
NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
G
Itpr2
inositol 1,4,5-trisphosphate receptor, type 2
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of ITPR2 mRNA]
CTD
PMID:29095437
NCBI chr 4:179,028,594...179,434,657
Ensembl chr 4:179,027,281...179,404,164
G
Jkamp
JNK1/MAPK8-associated membrane protein
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of JKAMP mRNA]
CTD
PMID:29095437
NCBI chr 6:90,648,043...90,661,985
Ensembl chr 6:90,648,160...90,662,501
G
Jun
Jun proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
Metformin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of JUN protein]
CTD
PMID:20590612
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
G
Junb
JunB proto-oncogene, AP-1 transcription factor subunit
decreases expression
EXP
Metformin results in decreased expression of JUNB mRNA
CTD
PMID:31324951
NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
G
Jund
JunD proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
Metformin results in increased expression of JUND mRNA
CTD
PMID:19022234
NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799
G
Kbtbd12
kelch repeat and BTB domain containing 12
increases expression
EXP
Metformin results in increased expression of KBTBD12 mRNA
CTD
PMID:31324951
NCBI chr 4:121,014,636...121,088,701
Ensembl chr 4:121,016,257...121,088,443
G
Keap1
Kelch-like ECH-associated protein 1
decreases expression multiple interactions
EXP ISO
Metformin results in decreased expression of KEAP1 mRNA Metformin promotes the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of KEAP1 mRNA] Metformin inhibits the reaction [Streptozocin results in increased expression of KEAP1 mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of KEAP1 protein]
CTD
PMID:25596134 PMID:33639173 PMID:37120126
NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
G
Klf15
KLF transcription factor 15
decreases expression
ISO
Metformin results in decreased expression of KLF15 mRNA
CTD
PMID:24428821
NCBI chr 4:122,965,718...122,978,403
Ensembl chr 4:122,965,807...122,978,374
G
Klf9
KLF transcription factor 9
decreases expression
EXP
Metformin results in decreased expression of KLF9 mRNA
CTD
PMID:31324951
NCBI chr 1:220,700,108...220,725,110
Ensembl chr 1:220,700,108...220,725,037
G
Klhl33
kelch-like family member 33
decreases expression
EXP
Metformin results in decreased expression of KLHL33 mRNA
CTD
PMID:31324951
NCBI chr15:24,105,923...24,114,445
Ensembl chr15:24,105,930...24,114,438
G
Kras
KRAS proto-oncogene, GTPase
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of KRAS mRNA
CTD
PMID:29309887
NCBI chr 4:178,185,418...178,218,484
G
Krt19
keratin 19
increases expression
EXP
Metformin results in increased expression of KRT19 mRNA
CTD
PMID:25596134
NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799
G
Krt80
keratin 80
increases expression
ISO
Metformin results in increased expression of KRT80 mRNA
CTD
PMID:21527772
NCBI chr 7:132,463,216...132,485,134
Ensembl chr 7:132,463,218...132,485,508
G
Lamc2
laminin subunit gamma 2
decreases expression
EXP
Metformin results in decreased expression of LAMC2 mRNA
CTD
PMID:31324951
NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200
G
Lars1
leucyl-tRNA synthetase 1
increases expression
EXP
Metformin results in increased expression of LARS1 mRNA
CTD
PMID:25596134
NCBI chr18:34,201,555...34,256,003
Ensembl chr18:34,201,549...34,255,931
G
Lcn2
lipocalin 2
multiple interactions
EXP
Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of LCN2 protein]
CTD
PMID:30551545
NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
G
Lcorl
ligand dependent nuclear receptor corepressor-like
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of LCORL mRNA]
CTD
PMID:29095437
NCBI chr14:65,271,339...65,407,732
Ensembl chr14:65,271,135...65,404,174
G
Ldha
lactate dehydrogenase A
multiple interactions
ISO
Metformin inhibits the reaction [Doxorubicin results in increased activity of LDHA protein]; Metformin inhibits the reaction [Doxorubicin results in increased expression of LDHA protein]; Metformin inhibits the reaction [Doxorubicin results in increased secretion of LDHA protein]
CTD
PMID:37453608 PMID:38364893
NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
G
Ldlr
low density lipoprotein receptor
multiple interactions
ISO
Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of LDLR protein] Metformin inhibits the reaction [AGT protein results in increased expression of LDLR protein]; Metformin inhibits the reaction [Hydrogen Peroxide results in increased expression of LDLR protein]
CTD
PMID:29499335
NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
G
Leap2
liver enriched antimicrobial peptide 2
increases expression
EXP
Metformin results in increased expression of LEAP2 mRNA
CTD
PMID:31324951
NCBI chr10:37,580,172...37,581,244
Ensembl chr10:37,577,855...37,581,244
G
Lep
leptin
increases expression multiple interactions
ISO
Metformin results in increased expression of LEP protein Metformin inhibits the reaction [Olanzapine results in increased expression of LEP protein]
CTD
PMID:20869956 PMID:32652086
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
G
Lgals5
galectin 5
decreases expression
EXP
Metformin results in decreased expression of LGALS5 mRNA
CTD
PMID:31324951
NCBI chr10:63,853,949...63,857,198
Ensembl chr10:63,853,935...63,857,153
G
Lhb
luteinizing hormone subunit beta
multiple interactions
EXP
Metformin inhibits the reaction [Letrozole results in increased secretion of LHB protein]
CTD
PMID:32298659
NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
G
Lingo3
leucine rich repeat and Ig domain containing 3
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in increased expression of LINGO3 mRNA
CTD
PMID:29309887
NCBI chr 7:8,869,025...8,878,431
Ensembl chr 7:8,869,025...8,878,431
G
Lmcd1
LIM and cysteine-rich domains 1
decreases expression
EXP
Metformin results in decreased expression of LMCD1 mRNA
CTD
PMID:25596134
NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046
G
Lmna
lamin A/C
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of LMNA mRNA]
CTD
PMID:29095437
NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423
G
LOC102546572
zinc finger protein 709-like
decreases expression
EXP
Metformin results in decreased expression of ZFP871 mRNA
CTD
PMID:31324951
NCBI chr 7:11,846,077...11,868,732
Ensembl chr 7:11,845,560...11,868,717
G
Lox
lysyl oxidase
affects expression
EXP
Metformin affects the expression of LOX mRNA
CTD
PMID:31324951
NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477
G
Lpar3
lysophosphatidic acid receptor 3
decreases expression
EXP
Metformin results in decreased expression of LPAR3 mRNA
CTD
PMID:31324951
NCBI chr 2:235,125,234...235,193,916
Ensembl chr 2:235,149,065...235,193,357
G
Lpin2
lipin 2
decreases expression
EXP
Metformin results in decreased expression of LPIN2 mRNA
CTD
PMID:31324951
NCBI chr 9:111,083,378...111,158,193
Ensembl chr 9:111,083,745...111,158,193
G
Lss
lanosterol synthase
increases expression
EXP
Metformin results in increased expression of LSS mRNA
CTD
PMID:31324951
NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
G
Ltn1
listerin E3 ubiquitin protein ligase 1
decreases expression
EXP
Metformin results in decreased expression of LTN1 mRNA
CTD
PMID:25596134
NCBI chr11:26,603,903...26,660,871
Ensembl chr11:26,603,903...26,660,886
G
Lurap1l
leucine rich adaptor protein 1-like
decreases expression
EXP
Metformin results in decreased expression of LURAP1L mRNA
CTD
PMID:31324951
NCBI chr 5:95,362,005...95,409,439
Ensembl chr 5:95,362,005...95,409,438
G
Lyst
lysosomal trafficking regulator
decreases expression
EXP
Metformin results in decreased expression of LYST mRNA
CTD
PMID:31324951
NCBI chr17:86,241,384...86,443,501
Ensembl chr17:86,241,384...86,443,480
G
Mad2l1
mitotic arrest deficient 2 like 1
affects expression
ISO
Metformin affects the expression of MAD2L1 mRNA
CTD
PMID:35568294
NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470
G
Mafg
MAF bZIP transcription factor G
increases expression
EXP
Metformin results in increased expression of MAFG mRNA
CTD
PMID:25596134
NCBI chr10:105,903,307...105,911,808
Ensembl chr10:105,903,237...105,912,026
G
Magohb
mago homolog B, exon junction complex subunit
increases expression
EXP
Metformin results in increased expression of MAGOHB mRNA
CTD
PMID:31324951
NCBI chr 4:165,034,131...165,041,977
Ensembl chr 4:165,034,122...165,041,967
G
Man1a2
mannosidase, alpha, class 1A, member 2
increases expression
EXP
Metformin results in increased expression of MAN1A2 mRNA
CTD
PMID:25596134
NCBI chr 2:187,947,484...188,096,332
Ensembl chr 2:187,951,617...188,096,332
G
Map1lc3b
microtubule-associated protein 1 light chain 3 beta
multiple interactions
ISO EXP
[Simvastatin co-treated with Metformin] results in increased expression of MAP1LC3B protein modified form; Chloroquine promotes the reaction [[Simvastatin co-treated with Metformin] results in increased expression of MAP1LC3B protein modified form] Metformin inhibits the reaction [Blood Glucose results in increased lipidation of MAP1LC3B protein]
CTD
PMID:25412314 PMID:33021114
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
G
Map2k3
mitogen activated protein kinase kinase 3
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of MAP2K3 mRNA
CTD
PMID:29309887
NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492
G
Map3k2
mitogen activated protein kinase kinase kinase 2
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of MAP3K2 mRNA
CTD
PMID:29309887
NCBI chr18:23,807,218...23,879,722
Ensembl chr18:23,807,218...23,871,433
G
Map3k7
mitogen activated protein kinase kinase kinase 7
multiple interactions increases activity
ISO EXP
[Paclitaxel co-treated with Metformin] results in decreased expression of MAP3K7 mRNA Metformin increases activity of Map3k7 protein in cardiac muscle cells
CTD RGD
PMID:29309887 PMID:17085580
RGD:155791450
NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
G
Map4k2
mitogen activated protein kinase kinase kinase kinase 2
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of MAP4K2 mRNA]
CTD
PMID:29095437
NCBI chr 1:203,645,098...203,660,782
Ensembl chr 1:203,645,153...203,660,331
G
Mapk1
mitogen activated protein kinase 1
multiple interactions decreases phosphorylation
ISO EXP
Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein] Metformin results in decreased phosphorylation of MAPK1 protein Metformin inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein]; PRKAA1 gene mutant form inhibits the reaction [Metformin results in increased phosphorylation of MAPK1 protein]
CTD
PMID:16385087 PMID:16760380 PMID:20590612 PMID:23707609 PMID:33639173
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
G
Mapk10
mitogen activated protein kinase 10
multiple interactions
ISO
Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK10 protein]
CTD
PMID:16385087
NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201
G
Mapk14
mitogen activated protein kinase 14
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of MAPK14 mRNA
CTD
PMID:29309887
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
G
Mapk3
mitogen activated protein kinase 3
multiple interactions decreases phosphorylation
ISO EXP
Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein] Metformin results in decreased phosphorylation of MAPK3 protein Metformin inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK3 protein]; PRKAA1 gene mutant form inhibits the reaction [Metformin results in increased phosphorylation of MAPK3 protein]
CTD
PMID:16385087 PMID:16760380 PMID:20590612 PMID:23707609 PMID:33639173
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
G
Mapk8
mitogen-activated protein kinase 8
multiple interactions
EXP ISO
Metformin inhibits the reaction [Glucose results in increased phosphorylation of MAPK8 protein] Metformin inhibits the reaction [INS protein results in increased expression of MAPK8 protein]
CTD
PMID:34801538 PMID:36764371
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
G
Mapk9
mitogen-activated protein kinase 9
multiple interactions
ISO
Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK9 protein]
CTD
PMID:16385087
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
G
Mcl1
MCL1 apoptosis regulator, BCL2 family member
decreases expression multiple interactions
ISO
Metformin results in decreased expression of MCL1 protein [Metformin co-treated with NVP-BKM120] results in decreased expression of MCL1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Metformin results in decreased expression of MCL1 protein]
CTD
PMID:33838154 PMID:38479708
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
G
Mcm10
minichromosome maintenance 10 replication initiation factor
increases expression
EXP
Metformin results in increased expression of MCM10 mRNA
CTD
PMID:31324951
NCBI chr17:73,263,788...73,288,346
Ensembl chr17:73,266,095...73,287,364
G
Mctp2
multiple C2 and transmembrane domain containing 2
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of MCTP2 mRNA]
CTD
PMID:29095437
NCBI chr 1:125,769,932...126,002,886
Ensembl chr 1:125,771,233...126,002,928
G
Mdm2
MDM2 proto-oncogene
increases expression
EXP
Metformin results in increased expression of MDM2 mRNA
CTD
PMID:25596134
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
G
Me1
malic enzyme 1
increases expression decreases expression
EXP ISO
Metformin results in increased expression of ME1 mRNA Metformin results in decreased expression of ME1 protein
CTD
PMID:25596134 PMID:28576465 PMID:31324951
NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
G
Med29
mediator complex subunit 29
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of MED29 mRNA]
CTD
PMID:29095437
NCBI chr 1:83,677,961...83,683,365
Ensembl chr 1:83,677,961...83,683,365
G
Mef2a
myocyte enhancer factor 2a
increases expression
ISO
Metformin results in increased expression of MEF2A mRNA
CTD
PMID:15864539
NCBI chr 1:120,847,874...120,982,488
Ensembl chr 1:120,850,080...120,981,948
G
Mef2b
myocyte enhancer factor 2B
increases expression
ISO
Metformin results in increased expression of MEF2B mRNA
CTD
PMID:23457588
NCBI chr16:19,253,008...19,269,514
Ensembl chr16:19,253,010...19,268,967
G
Mef2c
myocyte enhancer factor 2C
increases expression
ISO
Metformin results in increased expression of MEF2C mRNA
CTD
PMID:15864539
NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880
G
Mef2d
myocyte enhancer factor 2D
increases expression
ISO
Metformin results in increased expression of MEF2D mRNA
CTD
PMID:15864539
NCBI chr 2:173,606,054...173,635,620
Ensembl chr 2:173,606,490...173,634,457
G
Mettl1
methyltransferase 1, tRNA methylguanosine
increases expression
EXP
Metformin results in increased expression of METTL1 mRNA
CTD
PMID:31324951
NCBI chr 7:62,864,860...62,869,202
Ensembl chr 7:62,864,853...62,869,202
G
Mettl22
methyltransferase 22, Kin17 lysine
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of METTL22 mRNA]
CTD
PMID:29095437
NCBI chr10:7,113,602...7,130,715
Ensembl chr10:7,113,660...7,130,654
G
Mfn2
mitofusin 2
multiple interactions
EXP ISO
Metformin inhibits the reaction [Glucose results in decreased expression of MFN2 protein] Metformin inhibits the reaction [INS protein results in decreased expression of MFN2 protein]
CTD
PMID:30144576 PMID:36764371
NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
G
Mfsd2a
MFSD2 lysolipid transporter A, lysophospholipid
affects expression
EXP
Metformin affects the expression of MFSD2A mRNA
CTD
PMID:31324951
NCBI chr 5:135,225,801...135,240,744
Ensembl chr 5:135,225,816...135,240,690
G
Mgat2
alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
increases expression
EXP
Metformin results in increased expression of MGAT2 mRNA
CTD
PMID:31324951
NCBI chr 6:87,656,360...87,658,849
Ensembl chr 6:87,656,349...87,658,177
G
Micu1
mitochondrial calcium uptake 1
multiple interactions
ISO
Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of MICU1 mRNA]; Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of MICU1 protein]
CTD
PMID:37337224
NCBI chr20:27,668,681...27,816,322
Ensembl chr20:27,668,747...27,814,964
G
Mid1ip1
MID1 interacting protein 1
increases expression
EXP
Metformin results in increased expression of MID1IP1 mRNA
CTD
PMID:31324951
NCBI chr X:12,060,993...12,063,318
Ensembl chr X:12,060,883...12,065,774
G
Mir1
microRNA 1
increases expression
EXP
Metformin results in increased expression of MIR1 mRNA
CTD
PMID:31324951
NCBI chr18:1,887,537...1,887,623
G
Mir146a
microRNA 146a
multiple interactions
EXP
Metformin inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary] results in decreased expression of MIR146A mRNA]
CTD
PMID:30290168
NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610
G
Mir148a
microRNA 148a
increases expression multiple interactions
ISO EXP
Metformin increases expression of MIR148A RNA in umbilical vein endothelial cells Metformin co-treated with metformin hydrochloride co-treated with N(gamma)-nitro-L-arginine methyl ester inhibits the reaction [pre-eclampsia decreases expression of MIR148A RNA in peripheral blood]
RGD
PMID:31203154 PMID:31203154
RGD:213230155 , RGD:213230155
NCBI chr 4:80,333,762...80,333,858
Ensembl chr 4:80,333,762...80,333,858
G
Mir152
microRNA 152
multiple interactions
EXP
Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin] inhibits the reaction [Ovalbumin results in increased expression of MIR152 mRNA]]
CTD
PMID:36547818
NCBI chr10:81,832,936...81,833,020
Ensembl chr10:81,832,936...81,833,020
G
Mir155
microRNA 155
multiple interactions
EXP
Metformin inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary] results in increased expression of MIR155 mRNA]
CTD
PMID:30290168
NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718
G
Mir15b
microRNA 15b
increases expression
EXP
Metformin results in increased expression of MIR15B mRNA
CTD
PMID:31324951
NCBI chr 2:153,245,200...153,245,297
Ensembl chr 2:153,245,200...153,245,297
G
Mir190
microRNA 190
decreases expression
EXP
Metformin results in decreased expression of MIR190 mRNA
CTD
PMID:31324951
NCBI chr 8:67,850,987...67,851,071
Ensembl chr 8:67,850,987...67,851,071
G
Mir19a
microRNA 19a
multiple interactions
ISO
Metformin inhibits the reaction [Oxygen deficiency results in decreased expression of MIR19A mRNA]
CTD
PMID:33476677
NCBI chr15:92,180,912...92,180,993
Ensembl chr15:92,180,912...92,180,993
G
Mir200a
microRNA 200a
multiple interactions
ISO
Metformin promotes the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of MIR200A]
CTD
PMID:37120126
NCBI chr 5:166,648,494...166,648,582
G
Mir216a
microRNA 216a
multiple interactions increases expression
EXP ISO
Metformin co-treated with metformin hydrochloride co-treated with N(gamma)-nitro-L-arginine methyl ester inhibits the reaction [pre-eclampsia decreases expression of Mir216a RNA in peripheral blood] Metformin increases expression of MIR216A RNA in umbilical vein endothelial cells
RGD
PMID:31203154 PMID:31203154
RGD:213230155 , RGD:213230155
NCBI chr14:102,524,105...102,524,210
Ensembl chr14:102,524,105...102,524,210
G
Mir29b2
microRNA 29b-2
decreases expression
EXP
Metformin results in decreased expression of MIR29B2 mRNA
CTD
PMID:31324951
NCBI chr13:106,570,371...106,570,451
Ensembl chr13:106,570,367...106,570,456
G
Mir99b
microRNA 99b
multiple interactions
EXP
Metformin inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary] results in decreased expression of MIR99B mRNA]
CTD
PMID:30290168
NCBI chr 1:58,677,015...58,677,084
Ensembl chr 1:58,677,011...58,677,090
G
Mme
membrane metallo-endopeptidase
decreases expression
EXP
Metformin results in decreased expression of MME mRNA
CTD
PMID:31324951
NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
G
Mmp10
matrix metallopeptidase 10
multiple interactions
ISO
Metformin inhibits the reaction [IL13 protein results in increased expression of MMP10 mRNA]
CTD
PMID:26497364
NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748
G
Mmp14
matrix metallopeptidase 14
multiple interactions
ISO
Metformin inhibits the reaction [IL13 protein results in increased expression of MMP14 mRNA]
CTD
PMID:26497364
NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
G
Mmp19
matrix metallopeptidase 19
increases expression
EXP
Metformin results in increased expression of MMP19 mRNA
CTD
PMID:25596134
NCBI chr 7:1,221,229...1,229,555
Ensembl chr 7:1,221,343...1,229,555
G
Mmp2
matrix metallopeptidase 2
multiple interactions decreases expression decreases activity
ISO
[Metformin co-treated with NVP-BKM120] results in decreased expression of MMP2 protein; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 protein] Metformin results in decreased expression of MMP2 mRNA Metformin results in decreased activity of MMP2 protein
CTD
PMID:20590612 PMID:22246099 PMID:38479708
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
G
Mmp9
matrix metallopeptidase 9
multiple interactions decreases expression decreases activity
ISO
[Metformin co-treated with NVP-BKM120] results in decreased expression of MMP9 protein; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein] Metformin inhibits the reaction [IL13 protein results in increased expression of MMP9 mRNA] Metformin results in decreased expression of MMP9 mRNA Metformin results in decreased activity of MMP9 protein
CTD
PMID:20590612 PMID:22246099 PMID:26497364 PMID:38479708
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
G
Mocos
molybdenum cofactor sulfurase
decreases expression
EXP
Metformin results in decreased expression of MOCOS mRNA
CTD
PMID:31324951
NCBI chr18:15,931,659...15,977,415
Ensembl chr18:15,931,654...15,977,187
G
Mpo
myeloperoxidase
multiple interactions
ISO
Metformin inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein]
CTD
PMID:24717679
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
G
Mrc1
mannose receptor, C type 1
multiple interactions
ISO
Metformin inhibits the reaction [IL13 protein results in increased expression of MRC1 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of MRC1 protein]; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MRC1 mRNA]; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MRC1 protein]
CTD
PMID:26497364
NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857
G
Msc
musculin
decreases expression
EXP
Metformin results in decreased expression of MSC mRNA
CTD
PMID:25596134
NCBI chr 5:4,547,335...4,553,206
Ensembl chr 5:4,547,405...4,553,203
G
Msmo1
methylsterol monooxygenase 1
increases expression
EXP
Metformin results in increased expression of MSMO1 mRNA
CTD
PMID:31324951
NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016
G
Mt-atp6
mitochondrially encoded ATP synthase membrane subunit 6
multiple interactions
ISO
Metformin inhibits the reaction [INS protein results in decreased expression of ATP6 protein]
CTD
PMID:36764371
NCBI chr MT:7,919...8,599 NCBI chr MT:7,919...8,599 NCBI chr MT:7,919...8,599 NCBI chr MT:7,919...8,599 NCBI chr MT:7,919...8,599 NCBI chr MT:7,919...8,599 NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599
G
Mt-co1
mitochondrially encoded cytochrome c oxidase I
increases expression
ISO
Metformin results in increased expression of COX1 protein
CTD
PMID:23166782
NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
G
Mt1
metallothionein 1
affects expression
EXP
Metformin affects the expression of MT1A mRNA; Metformin affects the expression of MT1F mRNA; Metformin affects the expression of MT1M mRNA
CTD
PMID:31324951
NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049
G
Mt2A
metallothionein 2A
affects expression
EXP
Metformin affects the expression of MT2A mRNA
CTD
PMID:31324951
NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
G
Mtdh
metadherin
increases expression
EXP
Metformin results in increased expression of MTDH mRNA
CTD
PMID:25596134
NCBI chr 7:65,306,464...65,365,647
Ensembl chr 7:65,306,400...65,364,413
G
Mtor
mechanistic target of rapamycin kinase
multiple interactions decreases expression decreases expression decreases phosphorylation
ISO EXP
[Metformin co-treated with Pioglitazone] results in decreased expression of MTOR mRNA; Metformin results in decreased phosphorylation of and results in increased expression of MTOR protein Metformin results in decreased expression of MTOR protein modified form Metformin decreases expression of MTOR protein in epithelial cell of alveolus of lung Metformin results in decreased phosphorylation of MTOR protein
CTD RGD
PMID:23363784 PMID:27363783 PMID:32589349 PMID:33838154 PMID:23632475
RGD:150404268
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
G
Mug2
murinoglobulin 2
decreases expression
ISO
Metformin results in decreased expression of MUG2 mRNA
CTD
PMID:23457588
NCBI chr 4:155,164,061...155,236,894
Ensembl chr 4:155,164,011...155,236,475
G
Mvd
mevalonate diphosphate decarboxylase
increases expression
EXP
Metformin results in increased expression of MVD mRNA
CTD
PMID:31324951
NCBI chr19:50,496,366...50,506,429
Ensembl chr19:50,496,367...50,507,971
G
Mx2
MX dynamin like GTPase 2
increases expression
EXP
Metformin results in increased expression of MX2 mRNA
CTD
PMID:31324951
NCBI chr11:36,905,698...36,936,308
Ensembl chr11:36,906,111...36,930,342
G
Myc
MYC proto-oncogene, bHLH transcription factor
increases expression decreases expression multiple interactions
ISO EXP
Metformin results in increased expression of MYC mRNA Metformin results in decreased expression of MYC protein [Paclitaxel co-treated with Metformin] results in decreased expression of MYC mRNA Metformin results in decreased expression of MYC mRNA
CTD
PMID:19022234 PMID:29226720 PMID:29309887
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
G
Myd88
MYD88, innate immune signal transduction adaptor
multiple interactions
EXP
Metformin inhibits the reaction [Isoproterenol results in increased expression of MYD88 mRNA]
CTD
PMID:24842192
NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
G
Myh6
myosin heavy chain 6
multiple interactions
EXP
Metformin inhibits the reaction [Doxorubicin results in decreased expression of MYH6 mRNA]
CTD
PMID:22666520
NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720
G
Myh7
myosin heavy chain 7
multiple interactions
EXP
Metformin inhibits the reaction [Doxorubicin results in increased expression of MYH7 mRNA]
CTD
PMID:22666520
NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
G
Myzap
myocardial zonula adherens protein
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of MYZAP mRNA]
CTD
PMID:29095437
NCBI chr 8:72,155,817...72,243,036
Ensembl chr 8:72,131,530...72,243,036
G
Naglu
N-acetyl-alpha-glucosaminidase
multiple interactions
ISO EXP
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of NAGLU mRNA] Metformin inhibits the reaction [Streptozocin results in increased activity of NAGLU protein]
CTD
PMID:29095437 PMID:33639173
NCBI chr10:86,001,545...86,009,049
Ensembl chr10:86,001,566...86,008,972
G
Nampt
nicotinamide phosphoribosyltransferase
affects expression multiple interactions increases expression
ISO EXP
Metformin affects the expression of NAMPT mRNA; Metformin affects the expression of NAMPT protein Metformin inhibits the reaction [Letrozole results in increased expression of NAMPT mRNA] Metformin results in increased expression of NAMPT mRNA SIRT1 protein affects the reaction [Metformin affects the expression of NAMPT mRNA]
CTD
PMID:23315983 PMID:25596134 PMID:32298659
NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100
G
Nars1
asparaginyl-tRNA synthetase 1
decreases expression increases expression
EXP
Metformin results in decreased expression of NARS1 mRNA Metformin results in increased expression of NARS1 mRNA
CTD
PMID:25596134 PMID:31324951
NCBI chr18:57,989,308...58,005,584
Ensembl chr18:57,989,308...58,005,622
G
Ncapd2
non-SMC condensin I complex, subunit D2
increases expression
EXP
Metformin results in increased expression of NCAPD2 mRNA
CTD
PMID:25596134
NCBI chr 4:157,968,814...157,992,314
Ensembl chr 4:157,968,815...157,992,020
G
Ncf1
neutrophil cytosolic factor 1
decreases expression
EXP
Metformin results in decreased expression of NCF1 mRNA
CTD
PMID:31324951
NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
G
Ndufs8
NADH:ubiquinone oxidoreductase core subunit S8
multiple interactions
ISO
Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NDUFS8 mRNA]
CTD
PMID:37337224
NCBI chr 1:201,140,585...201,144,573
Ensembl chr 1:201,140,585...201,144,511
G
Nedd9
neural precursor cell expressed, developmentally down-regulated 9
decreases expression
EXP
Metformin results in decreased expression of NEDD9 mRNA
CTD
PMID:25596134
NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019
G
Nfe2l1
NFE2 like bZIP transcription factor 1
decreases expression multiple interactions increases degradation
ISO
Metformin results in decreased expression of NFE2L1 mRNA; Metformin results in decreased expression of NFE2L1 protein Metformin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NFE2L1 protein] Metformin results in increased degradation of NFE2L1 protein
CTD
PMID:33838154
NCBI chr10:81,796,055...81,812,926
Ensembl chr10:81,800,366...81,832,318
G
Nfe2l2
NFE2 like bZIP transcription factor 2
decreases expression multiple interactions increases activity affects activity
ISO EXP
Metformin results in decreased expression of NFE2L2 mRNA; Metformin results in decreased expression of NFE2L2 protein Metformin promotes the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of NFE2L2 protein] Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein]; Metformin inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 protein] Metformin results in increased activity of NFE2L2 protein Metformin affects the activity of NFE2L2 protein Metformin inhibits the reaction [2-tert-butylhydroquinone results in increased stability of and affects the localization of NFE2L2 protein]; Metformin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NFE2L2 protein]
CTD
PMID:22627169 PMID:23707609 PMID:25596134 PMID:30114225 PMID:33639173 PMID:33838154 PMID:36999408 PMID:37120126 More...
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
G
Nfkb1
nuclear factor kappa B subunit 1
multiple interactions
ISO EXP
[Paclitaxel co-treated with Metformin] results in decreased expression of NFKB1 mRNA Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of NFKB1 mRNA]; Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NFKB1 protein]
CTD
PMID:29309887 PMID:31100278 PMID:36999408
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
G
Nfkb2
nuclear factor kappa B subunit 2
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of NFKB2 mRNA
CTD
PMID:29309887
NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213
G
Nfkbia
NFKB inhibitor alpha
multiple interactions decreases expression
ISO EXP
Metformin results in decreased phosphorylation of and results in decreased degradation of NFKBIA protein Metformin results in decreased expression of NFKBIA mRNA
CTD
PMID:21054339 PMID:31324951
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
G
Nin
ninein
increases expression
EXP
Metformin results in increased expression of NIN mRNA
CTD
PMID:25596134
NCBI chr 6:88,525,405...88,627,710
Ensembl chr 6:88,525,742...88,627,639
G
Ninj1
ninjurin 1
increases expression
EXP
Metformin results in increased expression of NINJ1 mRNA
CTD
PMID:25596134
NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704
G
Nmur1
neuromedin U receptor 1
decreases expression
EXP
Metformin results in decreased expression of NMUR1 mRNA
CTD
PMID:25596134
NCBI chr 9:87,033,231...87,038,070
Ensembl chr 9:87,033,279...87,036,684
G
Noct
nocturnin
affects expression
EXP
Metformin affects the expression of NOCT mRNA
CTD
PMID:31324951
NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:135,271,189...135,291,400
G
Nod1
nucleotide-binding oligomerization domain containing 1
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of NOD1 mRNA
CTD
PMID:29309887
NCBI chr 4:84,060,871...84,111,668
Ensembl chr 4:84,060,880...84,111,404
G
Nop58
NOP58 ribonucleoprotein
increases expression
EXP
Metformin results in increased expression of NOP58 mRNA
CTD
PMID:31324951
NCBI chr 9:61,120,939...61,144,810
Ensembl chr 9:61,120,929...61,144,810
G
Nos1
nitric oxide synthase 1
affects response to substance
ISO
NOS1 protein affects the susceptibility to Metformin
CTD
PMID:20847317
NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
G
Nos2
nitric oxide synthase 2
increases response to substance multiple interactions increases expression
ISO EXP
NOS2 protein results in increased susceptibility to Metformin Metformin inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA]; Metformin inhibits the reaction [Streptozocin results in increased activity of NOS2 protein] Metformin results in increased expression of NOS2 protein
CTD
PMID:24770553 PMID:25108154 PMID:33639173
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
G
Nos3
nitric oxide synthase 3
multiple interactions
EXP ISO
Metformin inhibits the reaction [Fructose results in decreased phosphorylation of NOS3 protein]; Metformin inhibits the reaction [Palmitic Acid inhibits the reaction [Acetylcholine results in increased phosphorylation of NOS3 protein]] [Orotic Acid inhibits the reaction [Metformin results in increased phosphorylation of NOS3 protein]] which results in decreased abundance of Nitric Oxide; Orotic Acid inhibits the reaction [Metformin results in increased phosphorylation of NOS3 protein]
CTD
PMID:25108154 PMID:25601987
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
G
Nox4
NADPH oxidase 4
multiple interactions
EXP
Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NOX4 protein]
CTD
PMID:35085591
NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
G
Nphs1
NPHS1 adhesion molecule, nephrin
multiple interactions
EXP
Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in decreased expression of NPHS1 mRNA]
CTD
PMID:30551545
NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078
G
Nppa
natriuretic peptide A
multiple interactions
EXP
Metformin inhibits the reaction [Glucose results in increased expression of NPPA protein]
CTD
PMID:30144576
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
G
Npy
neuropeptide Y
multiple interactions
ISO
Metformin inhibits the reaction [Olanzapine results in increased expression of NPY mRNA]
CTD
PMID:32652086
NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
G
Nqo1
NAD(P)H quinone dehydrogenase 1
multiple interactions increases expression decreases expression
EXP ISO
Metformin inhibits the reaction [Doxorubicin results in decreased expression of NQO1 mRNA]; Metformin inhibits the reaction [Streptozocin results in decreased expression of NQO1 mRNA]; Metformin inhibits the reaction [Streptozocin results in decreased expression of NQO1 protein] Metformin promotes the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of NQO1 mRNA] Metformin results in increased expression of NQO1 mRNA Metformin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of and results in increased activity of NQO1 protein]; Metformin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of NQO1 mRNA] Metformin results in decreased expression of NQO1 protein Metformin results in decreased expression of NQO1 mRNA
CTD
PMID:21457706 PMID:22666520 PMID:23707609 PMID:25596134 PMID:25697376 PMID:33639173 PMID:37120126 More...
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
G
Nr0b2
nuclear receptor subfamily 0, group B, member 2
decreases expression
ISO
Metformin results in decreased expression of NR0B2 mRNA
CTD
PMID:24428821
NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
G
Nr1d1
nuclear receptor subfamily 1, group D, member 1
increases expression
EXP
Metformin results in increased expression of NR1D1 mRNA
CTD
PMID:31324951
NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705
G
Nr1i2
nuclear receptor subfamily 1, group I, member 2
decreases expression multiple interactions
EXP ISO
Metformin results in decreased expression of NR1I2 mRNA Metformin binds to and results in increased activity of NR1I2 protein Metformin binds to and results in increased activity of NR1I2 protein; NR1I2 protein affects the susceptibility to [Pregnenolone Carbonitrile co-treated with Metformin]
CTD
PMID:19022234 PMID:21920351 PMID:33049310
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
G
Nr1i3
nuclear receptor subfamily 1, group I, member 3
multiple interactions
EXP
Metformin promotes the reaction [Phenobarbital results in increased activity of NR1I3 protein]
CTD
PMID:20686344
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
G
Nr3c1
nuclear receptor subfamily 3, group C, member 1
decreases expression
ISO
Metformin results in decreased expression of NR3C1 mRNA; Metformin results in decreased expression of NR3C1 protein
CTD
PMID:25110054
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
G
Nr4a1
nuclear receptor subfamily 4, group A, member 1
decreases expression
EXP
Metformin results in decreased expression of NR4A1 mRNA
CTD
PMID:31324951
NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
G
Nr4a2
nuclear receptor subfamily 4, group A, member 2
decreases expression
EXP
Metformin results in decreased expression of NR4A2 mRNA
CTD
PMID:31324951
NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
G
Nr4a3
nuclear receptor subfamily 4, group A, member 3
decreases expression
EXP
Metformin results in decreased expression of NR4A3 mRNA
CTD
PMID:31324951
NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733
G
Nras
NRAS proto-oncogene, GTPase
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of NRAS mRNA
CTD
PMID:29309887
NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626
G
Nrf1
nuclear respiratory factor 1
increases expression
ISO
Metformin results in increased expression of NRF1 mRNA
CTD
PMID:16380484 PMID:24428821
NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328
G
Ntpcr
nucleoside-triphosphatase, cancer-related
decreases expression
EXP
Metformin results in decreased expression of NTPCR mRNA
CTD
PMID:25596134
NCBI chr19:53,701,496...53,715,260
Ensembl chr19:53,695,976...53,715,202
G
Ntrk2
neurotrophic receptor tyrosine kinase 2
multiple interactions
EXP
Metformin inhibits the reaction [Streptozocin results in increased expression of NTRK2 mRNA]
CTD
PMID:35414346
NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
G
Nupr1
nuclear protein 1, transcriptional regulator
increases expression
EXP
Metformin results in increased expression of NUPR1 mRNA
CTD
PMID:31324951
NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281
G
Oat
ornithine aminotransferase
decreases expression
EXP
Metformin results in decreased expression of OAT mRNA
CTD
PMID:31324951
NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682
G
Oga
O-GlcNAcase
multiple interactions
EXP
Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of OGA protein]
CTD
PMID:30551545
NCBI chr 1:244,598,285...244,633,835
Ensembl chr 1:244,598,292...244,634,359
G
Ogg1
8-oxoguanine DNA glycosylase
multiple interactions
ISO
Metformin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of OGG1 mRNA]
CTD
PMID:25697376
NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
G
Olr1
oxidized low density lipoprotein receptor 1
multiple interactions
EXP
Metformin affects the reaction [Dehydroepiandrosterone results in increased expression of OLR1 protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of OLR1 mRNA]
CTD
PMID:27634381
NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523
G
Olr906
olfactory receptor 906
decreases expression
EXP
Metformin results in decreased expression of OLR906 mRNA
CTD
PMID:31324951
NCBI chr 7:1,821,264...1,822,202
Ensembl chr 7:1,821,264...1,822,202
G
Onecut1
one cut homeobox 1
decreases expression
EXP
Metformin results in decreased expression of ONECUT1 mRNA
CTD
PMID:31324951
NCBI chr 8:75,599,432...75,633,598
Ensembl chr 8:75,599,740...75,627,277
G
Opa1
OPA1, mitochondrial dynamin like GTPase
multiple interactions
EXP
Metformin inhibits the reaction [Glucose results in decreased expression of OPA1 protein]
CTD
PMID:30144576
NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109
G
Orai3
ORAI calcium release-activated calcium modulator 3
decreases expression
EXP
Metformin results in decreased expression of ORAI3 mRNA
CTD
PMID:25596134
NCBI chr 1:182,381,196...182,386,055
Ensembl chr 1:182,344,293...182,386,052
G
Osgin1
oxidative stress induced growth inhibitor 1
decreases expression affects expression
EXP
Metformin results in decreased expression of OSGIN1 mRNA Metformin affects the expression of OSGIN1 mRNA
CTD
PMID:25596134 PMID:31324951
NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516
G
Otub2
OTU deubiquitinase, ubiquitin aldehyde binding 2
increases expression
EXP
Metformin results in increased expression of OTUB2 mRNA
CTD
PMID:31324951
NCBI chr 6:122,545,067...122,563,657
Ensembl chr 6:122,545,061...122,563,644
G
Otud1
OTU deubiquitinase 1
decreases expression
EXP
Metformin results in decreased expression of OTUD1 mRNA
CTD
PMID:31324951
NCBI chr17:82,259,920...82,262,770
Ensembl chr17:82,259,840...82,262,995
G
P2rx7
purinergic receptor P2X 7
increases expression
EXP
Metformin results in increased expression of P2RX7 mRNA
CTD
PMID:31324951
NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619
G
P4hb
prolyl 4-hydroxylase subunit beta
multiple interactions
EXP
Metformin inhibits the reaction [Glucose results in increased expression of P4HB protein]
CTD
PMID:34801538
NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500
G
Pank1
pantothenate kinase 1
decreases expression
EXP
Metformin results in decreased expression of PANK1 mRNA
CTD
PMID:25596134
NCBI chr 1:232,324,718...232,395,445
Ensembl chr 1:232,328,430...232,396,829
G
Parp1
poly (ADP-ribose) polymerase 1
multiple interactions increases cleavage increases expression
EXP ISO
Metformin inhibits the reaction [Dietary Fats results in increased expression of and results in increased cleavage of PARP1 protein] Metformin results in increased cleavage of PARP1 protein Deoxyglucose promotes the reaction [Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PARP1 protein modified form]]; Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PARP1 protein modified form] Metformin results in increased expression of PARP1 mRNA [epothilone A co-treated with Metformin] results in increased expression of PARP1 mRNA; plantamajoside promotes the reaction [Metformin results in increased cleavage of PARP1 protein]; Sodium Salicylate promotes the reaction [Metformin results in increased expression of PARP1 mRNA]; triciribine promotes the reaction [[epothilone A co-treated with Metformin] results in increased expression of PARP1 mRNA]
CTD
PMID:27551045 PMID:29095437 PMID:29117515 PMID:35350904
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
G
Pck1
phosphoenolpyruvate carboxykinase 1
multiple interactions decreases expression
ISO EXP
Metformin inhibits the reaction [Bucladesine results in increased expression of PCK1 mRNA]; Metformin inhibits the reaction [PPARGC1A protein results in increased expression of PCK1 mRNA] Metformin results in decreased expression of PCK1 mRNA
CTD
PMID:22117073 PMID:24428821 PMID:31324951
NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
G
Pde8a
phosphodiesterase 8A
decreases expression
EXP
Metformin results in decreased expression of PDE8A mRNA
CTD
PMID:25596134
NCBI chr 1:135,166,143...135,288,986
Ensembl chr 1:135,166,237...135,288,024
G
Pdha1
pyruvate dehydrogenase E1 subunit alpha 1
multiple interactions
ISO
Metformin results in decreased phosphorylation of and results in increased activity of PDHA1 protein
CTD
PMID:28576465
NCBI chr X:34,700,481...34,714,309
Ensembl chr X:34,700,409...34,714,311
G
Pdia5
protein disulfide isomerase family A, member 5
decreases expression
EXP
Metformin results in decreased expression of PDIA5 mRNA
CTD
PMID:25596134
NCBI chr11:65,272,152...65,359,087
Ensembl chr11:65,272,155...65,359,084
G
Pdk1
pyruvate dehydrogenase kinase 1
affects expression increases expression
EXP
Metformin affects the expression of PDK1 mRNA Metformin results in increased expression of PDK1 mRNA
CTD
PMID:25596134 PMID:31324951
NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
G
Pdk4
pyruvate dehydrogenase kinase 4
decreases expression
EXP
Metformin results in decreased expression of PDK4 mRNA
CTD
PMID:25596134
NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
G
Pdlim1
PDZ and LIM domain 1
increases expression
EXP
Metformin results in increased expression of PDLIM1 mRNA
CTD
PMID:25596134
NCBI chr 1:239,042,372...239,091,074
Ensembl chr 1:239,042,385...239,091,076
G
Pdlim3
PDZ and LIM domain 3
decreases expression
EXP
Metformin results in decreased expression of PDLIM3 mRNA
CTD
PMID:31324951
NCBI chr16:46,352,460...46,383,680
Ensembl chr16:46,352,467...46,383,657
G
Pdpk1
3-phosphoinositide dependent protein kinase-1
decreases expression
ISO
Metformin results in decreased expression of PDPK1 mRNA
CTD
PMID:32589349
NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623
G
Pdrg1
p53 and DNA damage regulated 1
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PDRG1 mRNA]
CTD
PMID:29095437
NCBI chr 3:141,477,561...141,483,730
Ensembl chr 3:141,476,501...141,483,858 Ensembl chr 3:141,476,501...141,483,858
G
Pdx1
pancreatic and duodenal homeobox 1
multiple interactions increases expression
ISO
[Metformin co-treated with Glucose] affects the localization of PDX1 protein Metformin results in increased expression of PDX1 protein
CTD
PMID:16489446
NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064
G
Pecam1
platelet and endothelial cell adhesion molecule 1
decreases expression
ISO
Metformin decreases expression of PECAM1 protein in epithelial cell of alveolus of lung
RGD
PMID:23632475
RGD:150404268
NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
G
Penk
proenkephalin
increases expression
EXP
Metformin results in increased expression of PENK mRNA
CTD
PMID:31324951
NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129
G
Per1
period circadian regulator 1
decreases expression
EXP
Metformin results in decreased expression of PER1 mRNA
CTD
PMID:31324951
NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431
G
Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
increases expression multiple interactions
EXP ISO
Metformin results in increased expression of PFKFB1 mRNA PFKFB1 gene mutant form inhibits the reaction [Metformin results in decreased abundance of Glucose-6-Phosphate metabolite]; PFKFB1 gene mutant form inhibits the reaction [Metformin results in increased abundance of Glyceraldehyde 3-Phosphate metabolite]
CTD
PMID:31324951 PMID:31974165
NCBI chr X:19,508,522...19,562,165
Ensembl chr X:19,508,546...19,562,182
G
Pgm2
phosphoglucomutase 2
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of PGM2 mRNA]
CTD
PMID:29095437
NCBI chr14:44,166,314...44,199,828
Ensembl chr14:44,164,425...44,199,967
G
Phgdh
phosphoglycerate dehydrogenase
increases expression
EXP
Metformin results in increased expression of PHGDH mRNA
CTD
PMID:25596134
NCBI chr 2:185,906,962...185,936,054
Ensembl chr 2:185,906,966...185,935,944
G
Phkg1
phosphorylase kinase catalytic subunit gamma 1
decreases expression
EXP
Metformin results in decreased expression of PHKG1 mRNA
CTD
PMID:31324951
NCBI chr12:26,838,822...26,854,547
Ensembl chr12:26,838,968...26,852,850
G
Phlda3
pleckstrin homology-like domain, family A, member 3
increases expression multiple interactions
EXP ISO
Metformin results in increased expression of PHLDA3 mRNA Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PHLDA3 mRNA]
CTD
PMID:25596134 PMID:29095437
NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335
G
Pias2
protein inhibitor of activated STAT, 2
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of PIAS2 mRNA]
CTD
PMID:29095437
NCBI chr18:70,608,034...70,714,295
Ensembl chr18:70,607,665...70,710,033
G
Pidd1
p53-induced death domain protein 1
increases expression
EXP
Metformin results in increased expression of PIDD1 mRNA
CTD
PMID:25596134
NCBI chr 1:196,536,815...196,542,808
Ensembl chr 1:196,536,834...196,542,699
G
Pik3c3
phosphatidylinositol 3-kinase, catalytic subunit type 3
decreases expression multiple interactions
ISO
Metformin results in decreased expression of PIK3C3 mRNA [Metformin co-treated with Pioglitazone] results in decreased expression of PIK3C3 mRNA
CTD
PMID:32589349
NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048
G
Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
multiple interactions decreases expression
ISO
[Metformin co-treated with Pioglitazone] results in decreased expression of PIK3CA mRNA Metformin results in decreased expression of PIK3CA mRNA
CTD
PMID:32589349
NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
G
Pik3cb
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
multiple interactions
ISO
[Metformin co-treated with Pioglitazone] results in decreased expression of PIK3CB mRNA
CTD
PMID:32589349
NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663
G
Pik3cg
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
decreases expression multiple interactions
ISO
Metformin results in decreased expression of PIK3CG mRNA [Metformin co-treated with Pioglitazone] results in decreased expression of PIK3CG mRNA
CTD
PMID:32589349
NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043
G
Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
increases expression multiple interactions decreases expression
ISO EXP
Metformin results in increased expression of PIK3R1 mRNA Metformin inhibits the reaction [Olanzapine results in decreased expression of PIK3R1 mRNA] Metformin results in decreased expression of PIK3R1 mRNA
CTD
PMID:21870829 PMID:31324951 PMID:32652086
NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
G
Pilra
paired immunoglobin-like type 2 receptor alpha
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PILRA mRNA]
CTD
PMID:29095437
NCBI chr12:17,787,169...17,798,149
Ensembl chr12:17,787,127...17,798,094
G
Pink1
PTEN induced kinase 1
multiple interactions
ISO
Metformin inhibits the reaction [Oleic Acid results in decreased expression of PINK1 protein] Metformin inhibits the reaction [Dietary Fats results in decreased expression of PINK1 protein]
CTD
PMID:36592823
NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
G
Pir
pirin
decreases expression
EXP
Metformin results in decreased expression of PIR mRNA
CTD
PMID:25596134
NCBI chr X:30,108,536...30,219,269
Ensembl chr X:30,108,538...30,219,218
G
Pklr
pyruvate kinase L/R
increases expression multiple interactions
EXP
Metformin results in increased expression of PKLR mRNA Metformin inhibits the reaction [Glucose results in increased expression of PKLR mRNA]
CTD
PMID:31324951 PMID:31974165
NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
G
Pla2g12a
phospholipase A2, group XIIA
affects expression
EXP
Metformin affects the expression of PLA2G12A mRNA
CTD
PMID:31324951
NCBI chr 2:218,436,497...218,452,742
Ensembl chr 2:218,436,513...218,452,740
G
Plat
plasminogen activator, tissue type
increases activity
ISO
Metformin results in increased activity of PLAT protein
CTD
PMID:1900072
NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
G
Pld1
phospholipase D1
decreases expression multiple interactions
ISO
Metformin results in decreased expression of PLD1 mRNA [Metformin co-treated with Pioglitazone] results in decreased expression of PLD1 mRNA
CTD
PMID:32589349
NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692
G
Plekhb1
pleckstrin homology domain containing B1
increases expression
EXP
Metformin results in increased expression of PLEKHB1 mRNA
CTD
PMID:31324951
NCBI chr 1:154,998,798...155,013,094
Ensembl chr 1:154,998,800...155,016,142
G
Plin2
perilipin 2
affects expression
EXP
Metformin affects the expression of PLIN2 mRNA
CTD
PMID:25596134
NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319
G
Plk2
polo-like kinase 2
increases expression
EXP
Metformin results in increased expression of PLK2 mRNA
CTD
PMID:31324951
NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947
G
Plppr1
phospholipid phosphatase related 1
increases expression
EXP
Metformin results in increased expression of PLPPR1 mRNA
CTD
PMID:31324951
NCBI chr 5:63,437,457...63,725,286
Ensembl chr 5:63,437,816...63,763,835
G
Pltp
phospholipid transfer protein
decreases expression
EXP
Metformin results in decreased expression of PLTP mRNA
CTD
PMID:31324951
NCBI chr 3:153,574,825...153,592,647
Ensembl chr 3:153,574,825...153,592,647
G
Pmepa1
prostate transmembrane protein, androgen induced 1
affects expression
EXP
Metformin affects the expression of PMEPA1 mRNA
CTD
PMID:25596134
NCBI chr 3:162,011,884...162,060,343
Ensembl chr 3:162,012,751...162,060,454
G
Pmm2
phosphomannomutase 2
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PMM2 mRNA]
CTD
PMID:29095437
NCBI chr10:6,961,521...6,982,913
Ensembl chr10:6,961,709...6,983,098
G
Pnpla3
patatin-like phospholipase domain containing 3
affects expression
EXP
Metformin affects the expression of PNPLA3 mRNA
CTD
PMID:31324951
NCBI chr 7:115,293,538...115,314,077
Ensembl chr 7:115,293,538...115,314,077
G
Pnpla6
patatin-like phospholipase domain containing 6
decreases expression
EXP
Metformin results in decreased expression of PNPLA6 mRNA
CTD
PMID:25596134
NCBI chr12:1,574,387...1,603,735
Ensembl chr12:1,560,363...1,603,734
G
Podxl
podocalyxin-like
increases expression
EXP
Metformin results in increased expression of PODXL mRNA
CTD
PMID:25596134
NCBI chr 4:60,135,124...60,181,829
Ensembl chr 4:60,135,109...60,181,899
G
Polr3f
RNA polymerase III subunit F
increases expression
EXP
Metformin results in increased expression of POLR3F mRNA
CTD
PMID:25596134
NCBI chr 3:131,908,466...131,924,838
Ensembl chr 3:131,908,466...131,924,837
G
Pomc
proopiomelanocortin
multiple interactions
ISO
Metformin inhibits the reaction [Olanzapine results in decreased expression of POMC mRNA]
CTD
PMID:32652086
NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
G
Pon1
paraoxonase 1
increases response to substance
ISO
PON1 gene mutant form results in increased susceptibility to Metformin
CTD
PMID:26945512
NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
G
Pou5f1
POU class 5 homeobox 1
multiple interactions
ISO
Metformin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to POU5F1 promoter]]; Metformin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to POU5F1 promoter]]
CTD
PMID:22132214
NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
G
Ppan
peter pan homolog
increases expression
EXP
Metformin results in increased expression of PPAN mRNA
CTD
PMID:25596134
NCBI chr 8:19,423,908...19,427,941
Ensembl chr 8:19,423,961...19,427,938
G
Ppara
peroxisome proliferator activated receptor alpha
multiple interactions increases expression increases activity decreases expression
ISO EXP
[rosiglitazone co-treated with Metformin] results in increased expression of PPARA mRNA; [rosiglitazone co-treated with Metformin] results in increased expression of PPARA protein; Metformin inhibits the reaction [Streptozocin results in decreased expression of PPARA mRNA] Metformin results in increased expression of PPARA mRNA Metformin results in increased activity of PPARA protein Metformin results in decreased expression of PPARA mRNA
CTD
PMID:20823565 PMID:22117073 PMID:23166782 PMID:23927877 PMID:29991592 PMID:31324951 More...
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
G
Pparg
peroxisome proliferator-activated receptor gamma
decreases expression multiple interactions affects activity increases expression
ISO EXP
Metformin results in decreased expression of PPARG mRNA Metformin inhibits the reaction [[cyhalothrin co-treated with Oleic Acid] results in increased expression of PPARG protein]; Metformin inhibits the reaction [INS protein results in increased expression of PPARG protein] Metformin inhibits the reaction [IL13 protein results in increased expression of PPARG mRNA] Metformin affects the activity of PPARG protein Metformin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of PPARG protein]; Metformin inhibits the reaction [Palmitic Acid results in decreased expression of PPARG mRNA] Metformin results in increased expression of PPARG mRNA
CTD
PMID:20724125 PMID:20956498 PMID:21870829 PMID:25108154 PMID:25596134 PMID:26497364 PMID:30256492 PMID:36529352 PMID:36764371 More...
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
G
Ppargc1a
PPARG coactivator 1 alpha
multiple interactions increases expression
ISO
PRKAA1 protein affects the reaction [Metformin results in increased expression of PPARGC1A mRNA] Metformin results in increased expression of PPARGC1A mRNA; Metformin results in increased expression of PPARGC1A protein dorsomorphin inhibits the reaction [Metformin results in increased expression of PPARGC1A mRNA]; Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of PPARGC1A protein]; Metformin inhibits the reaction [Bucladesine results in increased expression of PPARGC1A mRNA]; Metformin inhibits the reaction [GCG protein results in increased expression of PPARGC1A mRNA]; Metformin inhibits the reaction [Glucose results in decreased expression of PPARGC1A protein]; Metformin inhibits the reaction [PPARGC1A protein results in decreased expression of TNFSF12 mRNA]; Metformin inhibits the reaction [PPARGC1A protein results in increased expression of PCK1 mRNA]; PRKAA1 protein affects the reaction [Metformin results in increased expression of PPARGC1A mRNA]; PRKAA2 protein affects the reaction [Metformin results in increased expression of PPARGC1A mRNA]; SIRT1 mutant form inhibits the reaction [Metformin results in increased expression of PPARGC1A mRNA]
CTD
PMID:15864539 PMID:16380484 PMID:22117073 PMID:23090186 PMID:24428821 PMID:34302933 PMID:37337224 More...
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
G
Ppfibp1
PPFIA binding protein 1
increases expression
EXP
Metformin results in increased expression of PPFIBP1 mRNA
CTD
PMID:25596134
NCBI chr 4:179,807,579...179,951,428
Ensembl chr 4:179,808,794...179,951,428
G
Ppm1d
protein phosphatase, Mg2+/Mn2+ dependent, 1D
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PPM1D mRNA]
CTD
PMID:29095437
NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607
G
Ppm1k
protein phosphatase, Mg2+/Mn2+ dependent, 1K
decreases expression
EXP
Metformin results in decreased expression of PPM1K mRNA
CTD
PMID:31324951
NCBI chr 4:87,612,198...87,638,993
Ensembl chr 4:87,612,204...87,636,152
G
Ppp1r15a
protein phosphatase 1, regulatory subunit 15A
increases expression
EXP ISO
Metformin results in increased expression of PPP1R15A mRNA
CTD
PMID:25596134
NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
G
Ppp1r3c
protein phosphatase 1, regulatory subunit 3C
increases expression
EXP
Metformin results in increased expression of PPP1R3C mRNA
CTD
PMID:31324951
NCBI chr 1:234,460,958...234,465,961
Ensembl chr 1:234,460,652...234,465,961
G
Ppp4r2
protein phosphatase 4, regulatory subunit 2
decreases expression
EXP
Metformin results in decreased expression of PPP4R2 mRNA
CTD
PMID:25596134
NCBI chr 4:133,454,555...133,495,486
Ensembl chr 4:133,454,555...133,495,486
G
Prc1
protein regulator of cytokinesis 1
increases expression
EXP
Metformin results in increased expression of PRC1 mRNA
CTD
PMID:25596134
NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765
G
Prdm1
PR/SET domain 1
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in increased expression of PRDM1 mRNA
CTD
PMID:29309887
NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488
G
Prdx2
peroxiredoxin 2
decreases expression
ISO
Metformin results in decreased expression of PRDX2 mRNA
CTD
PMID:23457588
NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194
G
Prkaa1
protein kinase AMP-activated catalytic subunit alpha 1
multiple interactions increases phosphorylation affects response to substance
ISO EXP
Metformin inhibits the reaction [2-chloroethyl ethyl sulfide results in decreased phosphorylation of PRKAA1 protein]; Metformin inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]; Metformin results in increased phosphorylation of and results in increased activity of PRKAA1 protein; Orotic Acid inhibits the reaction [Metformin results in increased phosphorylation of PRKAA1 protein]; PRKAA1 protein affects the reaction [Metformin inhibits the reaction [Glucose deficiency results in increased chemical synthesis of Reactive Oxygen Species]]; PRKAA1 protein affects the reaction [Metformin results in decreased expression of ABCB1 protein]; PRKAA1 protein affects the reaction [Metformin results in decreased expression of RELA protein]; PRKAA1 protein affects the reaction [Metformin results in increased expression of PPARGC1A mRNA]; PRKAA1 protein affects the reaction [Metformin results in increased expression of SOD2 mRNA] Metformin increases expression and phosphorylation of PRKAA1 protein in epithelial cell of alveolus of lung PRKAA1 protein affects the susceptibility to Metformin 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Metformin results in increased phosphorylation of and results in increased activity of PRKAA1 protein]; Metformin results in increased phosphorylation of and results in increased activity of PRKAA1 protein; PRKAA1 gene mutant form inhibits the reaction [Metformin inhibits the reaction [FSHB protein results in increased expression of HSD3B protein]]; PRKAA1 gene mutant form inhibits the reaction [Metformin inhibits the reaction [FSHB protein results in increased expression of STAR protein]]; PRKAA1 gene mutant form inhibits the reaction [Metformin promotes the reaction [FSHB protein results in increased phosphorylation of PRKAA1 protein]]; PRKAA1 gene mutant form inhibits the reaction [Metformin results in decreased expression of HSD3B protein]; PRKAA1 gene mutant form inhibits the reaction [Metformin results in decreased secretion of Progesterone]; PRKAA1 gene mutant form inhibits the reaction [Metformin results in increased phosphorylation of MAPK1 protein]; PRKAA1 gene mutant form inhibits the reaction [Metformin results in increased phosphorylation of MAPK3 protein]; PRKAA1 gene mutant form inhibits the reaction [Metformin results in increased phosphorylation of PRKAA1 protein] [[PRKAA1 gene co-treated with PRKAA2 gene] affects the susceptibility to Metformin] which results in decreased abundance of Adenosine Triphosphate; [[PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to Metformin] which results in increased abundance of Glucose-6-Phosphate; [PRKAA1 gene co-treated with PRKAA2 gene] affects the susceptibility to Metformin; [PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to Metformin; Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of and results in decreased phosphorylation of PRKAA1 protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of PRKAA1 mRNA]; Metformin results in increased phosphorylation of and results in increased activity of PRKAA1 protein; PRKAA1 protein affects the reaction [Metformin results in increased expression of PPARGC1A mRNA]
CTD RGD
PMID:16380484 PMID:16760380 PMID:16873680 PMID:19052259 PMID:19594306 PMID:21054339 PMID:21186350 PMID:22815988 PMID:24428821 PMID:25601987 PMID:26497364 PMID:31974165 PMID:37121296 PMID:37337224 PMID:37481222 PMID:23632475 More...
RGD:150404268
NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
G
Prkaa2
protein kinase AMP-activated catalytic subunit alpha 2
multiple interactions increases phosphorylation increases activity affects response to substance
ISO EXP
Metformin inhibits the reaction [2-chloroethyl ethyl sulfide results in decreased phosphorylation of PRKAA2 protein]; Metformin results in increased phosphorylation of and results in increased activity of PRKAA2 protein metformin inhibits the reaction [lipopolysaccharide decreases expression of Prkaa2 mRNA in left cardiac chamber] and decreases expression of Prkaa2 mRNA in left cardiac chamber Metformin results in increased phosphorylation of PRKAA2 protein Metformin results in increased activity of PRKAA2 protein PRKAA2 protein affects the susceptibility to Metformin 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Metformin results in increased phosphorylation of and results in increased activity of PRKAA2 protein]; Metformin results in increased phosphorylation of and results in increased activity of PRKAA2 protein [[PRKAA1 gene co-treated with PRKAA2 gene] affects the susceptibility to Metformin] which results in decreased abundance of Adenosine Triphosphate; [[PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to Metformin] which results in increased abundance of Glucose-6-Phosphate; [PRKAA1 gene co-treated with PRKAA2 gene] affects the susceptibility to Metformin; [PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to Metformin; Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of PRKAA2 mRNA]; Metformin results in increased phosphorylation of and results in increased activity of PRKAA2 protein; PRKAA2 protein affects the reaction [Metformin results in increased expression of PPARGC1A mRNA]
CTD RGD
PMID:16873680 PMID:18484962 PMID:19052259 PMID:19594306 PMID:20847317 PMID:21186350 PMID:24428821 PMID:31974165 PMID:37337224 PMID:37481222 PMID:27621180 More...
RGD:39456138
NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543
G
Prkab2
protein kinase AMP-activated non-catalytic subunit beta 2
increases expression
EXP
Metformin results in increased expression of PRKAB2 mRNA
CTD
PMID:25596134
NCBI chr 2:185,257,218...185,272,846
Ensembl chr 2:185,257,213...185,269,872
G
Prkag2
protein kinase AMP-activated non-catalytic subunit gamma 2
multiple interactions
ISO
Metformin inhibits the reaction [Olanzapine results in increased expression of PRKAG2 mRNA]
CTD
PMID:32652086
NCBI chr 4:10,010,890...10,252,155
Ensembl chr 4:10,010,890...10,252,142
G
Prkca
protein kinase C, alpha
multiple interactions decreases expression
ISO
[Metformin co-treated with Pioglitazone] results in decreased expression of PRKCA mRNA; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PRKCA protein] Metformin results in decreased expression of PRKCA mRNA
CTD
PMID:20590612 PMID:32589349
NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
G
Prkcb
protein kinase C, beta
decreases expression multiple interactions
ISO
Metformin results in decreased expression of PRKCB mRNA; Metformin results in decreased expression of PRKCB protein Metformin inhibits the reaction [INS protein results in increased expression of PRKCB protein]
CTD
PMID:15531508 PMID:36764371
NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
G
Prkn
parkin RBR E3 ubiquitin protein ligase
multiple interactions
ISO
Metformin inhibits the reaction [Oleic Acid results in decreased expression of PRKN protein] Metformin inhibits the reaction [Dietary Fats results in decreased expression of PRKN protein]
CTD
PMID:36592823
NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
G
Prl
prolactin
decreases secretion
ISO
Metformin results in decreased secretion of PRL protein
CTD
PMID:21664031
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
G
Psat1
phosphoserine aminotransferase 1
increases expression
EXP
Metformin results in increased expression of PSAT1 mRNA
CTD
PMID:31324951
NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682
G
Pten
phosphatase and tensin homolog
multiple interactions
EXP
Metformin inhibits the reaction [Testosterone results in decreased expression of PTEN mRNA]
CTD
PMID:26492952
NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
G
Ptgfr
prostaglandin F receptor
decreases expression
EXP
Metformin results in decreased expression of PTGFR mRNA
CTD
PMID:31324951
NCBI chr 2:240,731,185...240,766,674
Ensembl chr 2:240,733,375...240,765,650
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions decreases expression
EXP ISO
Metformin inhibits the reaction [Dietary Fats results in increased expression of PTGS2 protein] Metformin results in decreased expression of PTGS2 mRNA
CTD
PMID:27551045 PMID:33838154
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
G
Ptpn1
protein tyrosine phosphatase, non-receptor type 1
multiple interactions
ISO
Metformin inhibits the reaction [INS protein results in increased expression of PTPN1 protein]
CTD
PMID:30928401
NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
G
Pxmp4
peroxisomal membrane protein 4
increases expression
EXP
Metformin results in increased expression of PXMP4 mRNA
CTD
PMID:31324951
NCBI chr 3:143,093,371...143,110,620
Ensembl chr 3:143,093,018...143,110,651
G
Pycr1
pyrroline-5-carboxylate reductase 1
increases expression
EXP
Metformin results in increased expression of PYCR1 mRNA
CTD
PMID:25596134
NCBI chr10:105,917,732...105,922,658
Ensembl chr10:105,917,680...105,922,549
G
Pygl
glycogen phosphorylase L
decreases expression
EXP
Metformin results in decreased expression of PYGL mRNA
CTD
PMID:25596134
NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310
G
Rab11a
RAB11a, member RAS oncogene family
increases expression multiple interactions
ISO
Metformin results in increased expression of RAB11A protein Metformin inhibits the reaction [Ethinyl Estradiol results in decreased expression of RAB11A protein]
CTD
PMID:34058177
NCBI chr 8:65,223,698...65,246,461
Ensembl chr 8:65,222,949...65,246,525
G
Rab33a
RAB33A, member RAS oncogene family
increases expression
EXP
Metformin results in increased expression of RAB33A mRNA
CTD
PMID:25596134
NCBI chr X:127,694,219...127,706,378
Ensembl chr X:127,694,964...127,706,378
G
Rab5a
RAB5A, member RAS oncogene family
multiple interactions
EXP
Metformin promotes the reaction [APPL1 protein binds to RAB5A protein]
CTD
PMID:29991592
NCBI chr 9:6,483,906...6,512,877
Ensembl chr 9:6,484,469...6,512,873
G
Rad51c
RAD51 paralog C
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of RAD51C mRNA]
CTD
PMID:29095437
NCBI chr10:72,205,032...72,231,643
Ensembl chr10:72,205,032...72,231,248
G
Raf1
Raf-1 proto-oncogene, serine/threonine kinase
decreases phosphorylation
ISO
Metformin results in decreased phosphorylation of RAF1 protein
CTD
PMID:23707609
NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
G
Rbp4
retinol binding protein 4
multiple interactions
EXP
Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased secretion of RBP4 protein]
CTD
PMID:19080170
NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399
G
Rbp7
retinol binding protein 7
increases expression
EXP
Metformin results in increased expression of RBP7 mRNA
CTD
PMID:31324951
NCBI chr 5:159,889,723...159,894,338
Ensembl chr 5:159,889,723...159,894,339
G
Rd3l
RD3 like
decreases expression
EXP
Metformin results in decreased expression of RD3L mRNA
CTD
PMID:31324951
NCBI chr 6:131,042,274...131,044,178
Ensembl chr 6:131,042,185...131,044,163
G
Reg3g
regenerating family member 3 gamma
increases expression
EXP
Metformin results in increased expression of REG3G mRNA
CTD
PMID:31324951
NCBI chr 4:110,922,805...110,927,803
Ensembl chr 4:110,924,168...110,926,723
G
Rela
RELA proto-oncogene, NF-kB subunit
decreases localization multiple interactions decreases phosphorylation
ISO EXP
Metformin results in decreased localization of RELA protein Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased phosphorylation of RELA protein] dorsomorphin inhibits the reaction [Metformin inhibits the reaction [Palmitic Acid results in increased phosphorylation of RELA protein]]; Metformin inhibits the reaction [Dehydroepiandrosterone affects the localization of RELA protein]; Metformin inhibits the reaction [Fructose results in increased phosphorylation of RELA protein]; Metformin inhibits the reaction [Palmitic Acid results in increased phosphorylation of RELA protein]; Niacinamide inhibits the reaction [Metformin inhibits the reaction [Palmitic Acid results in increased phosphorylation of RELA protein]] Metformin results in decreased phosphorylation of RELA protein [Paclitaxel co-treated with Metformin] results in decreased expression of RELA mRNA; Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of RELA protein]; Metformin inhibits the reaction [RELA protein results in increased expression of ABCB1 mRNA]; Metformin results in decreased expression of and affects the localization of RELA protein; PRKAA1 protein affects the reaction [Metformin results in decreased expression of RELA protein]
CTD
PMID:16385087 PMID:21054339 PMID:25108154 PMID:27634381 PMID:29309887 PMID:37120126 More...
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Retn
resistin
multiple interactions
EXP
Metformin inhibits the reaction [Fructose results in increased expression of RETN protein]; Metformin inhibits the reaction [Letrozole results in increased expression of RETN mRNA]
CTD
PMID:25108154 PMID:32298659
NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620
G
Rffl
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
decreases expression
EXP
Metformin results in decreased expression of RFFL mRNA
CTD
PMID:25596134
NCBI chr10:67,740,711...67,803,669
Ensembl chr10:67,740,712...67,824,434
G
RGD1309362
similar to interferon-inducible GTPase
increases expression
EXP
Metformin results in increased expression of RGD1309362 mRNA
CTD
PMID:31324951
G
Rgs2
regulator of G-protein signaling 2
decreases expression
EXP
Metformin results in decreased expression of RGS2 mRNA
CTD
PMID:31324951
NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
G
Rhd
Rh blood group, D antigen
decreases expression
EXP
Metformin results in decreased expression of RHD mRNA
CTD
PMID:31324951
NCBI chr 5:147,087,479...147,121,716
Ensembl chr 5:147,087,518...147,121,715
G
Rhoa
ras homolog family member A
decreases expression
ISO
Metformin results in decreased expression of RHOA protein
CTD
PMID:37121296
NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
G
Rhobtb1
Rho-related BTB domain containing 1
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of RHOBTB1 mRNA]
CTD
PMID:29095437
NCBI chr20:19,327,142...19,456,121
Ensembl chr20:19,327,155...19,403,012
G
Rictor
RPTOR independent companion of MTOR, complex 2
multiple interactions decreases expression
ISO
[Metformin co-treated with Pioglitazone] results in decreased expression of RICTOR mRNA Metformin results in decreased expression of RICTOR mRNA
CTD
PMID:32589349
NCBI chr 2:55,811,877...55,903,893
Ensembl chr 2:55,811,322...55,901,426
G
Ripk1
receptor interacting serine/threonine kinase 1
multiple interactions
ISO
[Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]; [Simvastatin co-treated with Metformin] results in increased expression of RIPK1 protein; necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]]; RIPK3 protein affects the reaction [necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]]]
CTD
PMID:25412314
NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
G
Ripk2
receptor-interacting serine-threonine kinase 2
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of RIPK2 mRNA
CTD
PMID:29309887
NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657
G
Ripk3
receptor-interacting serine-threonine kinase 3
multiple interactions
ISO
[Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]; necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]]; RIPK3 protein affects the reaction [necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]]]
CTD
PMID:25412314
NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
G
Rlf
RLF zinc finger
increases expression
EXP
Metformin results in increased expression of RLF mRNA
CTD
PMID:25596134
NCBI chr 5:134,711,612...134,767,274
Ensembl chr 5:134,711,619...134,767,257
G
Rnasel
ribonuclease L
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of RNASEL mRNA]
CTD
PMID:29095437
NCBI chr13:65,894,990...65,910,354
Ensembl chr13:65,901,459...65,908,704
G
Rnd1
Rho family GTPase 1
affects expression
EXP
Metformin affects the expression of RND1 mRNA
CTD
PMID:25596134
NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:129,821,311...129,828,399
G
Rnd3
Rho family GTPase 3
affects expression increases expression
EXP
Metformin affects the expression of RND3 mRNA Metformin results in increased expression of RND3 mRNA
CTD
PMID:25596134 PMID:31324951
NCBI chr 3:35,571,929...35,589,283
Ensembl chr 3:35,571,143...35,589,327
G
Rnf121
ring finger protein 121
increases expression
EXP
Metformin results in increased expression of RNF121 mRNA
CTD
PMID:25596134
NCBI chr 1:156,377,368...156,439,936
Ensembl chr 1:156,377,364...156,446,826
G
Ro60
Ro60, Y RNA binding protein
affects expression
EXP
Metformin affects the expression of RO60 mRNA
CTD
PMID:25596134
NCBI chr13:55,499,514...55,520,504
Ensembl chr13:55,499,534...55,520,504
G
Rps6
ribosomal protein S6
decreases phosphorylation multiple interactions
ISO EXP
Metformin results in decreased phosphorylation of RPS6 protein Trientine inhibits the reaction [Metformin results in decreased phosphorylation of RPS6 protein] Metformin analog results in decreased phosphorylation of RPS6 protein; Metformin results in decreased phosphorylation of RPS6 protein
CTD
PMID:22492524 PMID:23363784
NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602 Ensembl chr 5:101,371,136...101,374,602
G
Rps6ka2
ribosomal protein S6 kinase A2
multiple interactions increases expression
ISO
[Metformin co-treated with Pioglitazone] results in increased expression of RPS6KA2 mRNA Metformin results in increased expression of RPS6KA2 mRNA
CTD
PMID:32589349
NCBI chr 1:52,631,582...52,906,739
Ensembl chr 1:52,631,736...52,906,739
G
Rps6ka5
ribosomal protein S6 kinase A5
multiple interactions decreases expression
ISO
[Metformin co-treated with Pioglitazone] results in decreased expression of RPS6KA5 mRNA Metformin results in decreased expression of RPS6KA5 mRNA
CTD
PMID:32589349
NCBI chr 6:119,828,823...120,006,190
Ensembl chr 6:119,828,846...120,006,224
G
Rps6kb1
ribosomal protein S6 kinase B1
multiple interactions decreases expression
ISO
3-benzyl-5-((2-nitrophenoxy)methyl)dihydrofuran-2(3H)-one inhibits the reaction [Metformin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RPS6KB1 protein]]; dorsomorphin inhibits the reaction [Metformin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RPS6KB1 protein]]; Metformin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RPS6KB1 protein] Metformin results in decreased expression of RPS6KB1 protein modified form [Paclitaxel co-treated with Metformin] results in decreased expression of RPS6KB1 mRNA; Metformin inhibits the reaction [cyanoginosin LR results in increased phosphorylation of RPS6KB1 protein]
CTD
PMID:29309887 PMID:29859833 PMID:33838154 PMID:34432352
NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
G
Rrm2
ribonucleotide reductase regulatory subunit M2
increases expression
EXP
Metformin results in increased expression of RRM2 mRNA
CTD
PMID:31324951
NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773
G
Rrm2b
ribonucleotide reductase regulatory TP53 inducible subunit M2B
increases expression
EXP
Metformin results in increased expression of RRM2B mRNA
CTD
PMID:25596134
NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633
G
Rsl1d1
ribosomal L1 domain containing 1
increases expression
EXP
Metformin results in increased expression of RSL1D1 mRNA
CTD
PMID:25596134
NCBI chr10:4,424,868...4,436,753
Ensembl chr10:4,397,821...4,439,593
G
Rtn3
reticulon 3
multiple interactions
EXP
Metformin inhibits the reaction [Glucose results in increased expression of RTN3 protein]
CTD
PMID:34801538
NCBI chr 1:204,612,675...204,669,212
Ensembl chr 1:204,612,675...204,669,275
G
Runx1
RUNX family transcription factor 1
increases expression
EXP
Metformin results in increased expression of RUNX1 mRNA
CTD
PMID:25596134
NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542
G
Runx2
RUNX family transcription factor 2
increases expression multiple interactions
EXP ISO
Metformin results in increased expression of RUNX2 protein Metformin inhibits the reaction [BMP2 protein results in increased expression of RUNX2 mRNA]; Metformin inhibits the reaction [BMP2 protein results in increased expression of RUNX2 protein]
CTD
PMID:19594306 PMID:37409753
NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
G
Rxra
retinoid X receptor alpha
decreases expression
EXP
Metformin results in decreased expression of RXRA mRNA
CTD
PMID:25596134
NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
G
Sall1
spalt-like transcription factor 1
increases expression
EXP
Metformin results in increased expression of SALL1 mRNA
CTD
PMID:31324951
NCBI chr19:18,005,782...18,022,705
Ensembl chr19:18,007,503...18,022,705
G
Samt2
spermatogenesis associated multipass transmembrane protein 2
increases expression
EXP
Metformin results in increased expression of SAMT2 mRNA
CTD
PMID:31324951
NCBI chr X:23,355,211...23,407,134
Ensembl chr X:23,342,423...23,358,120
G
Sars1
seryl-tRNA synthetase 1
increases expression
EXP
Metformin results in increased expression of SARS1 mRNA
CTD
PMID:25596134
NCBI chr 2:196,065,543...196,081,240
Ensembl chr 2:196,065,430...196,081,277
G
Sat1
spermidine/spermine N1-acetyl transferase 1
increases expression
EXP
Metformin results in increased expression of SAT1 mRNA
CTD
PMID:25596134
NCBI chr X:40,158,354...40,161,641
Ensembl chr X:40,157,046...40,196,813
G
Sbk1
SH3 domain binding kinase 1
increases expression
EXP
Metformin results in increased expression of SBK1 mRNA
CTD
PMID:31324951
NCBI chr 1:180,807,092...180,851,910
Ensembl chr 1:180,807,099...180,851,885
G
Scamp1
secretory carrier membrane protein 1
increases expression
EXP
Metformin results in increased expression of SCAMP1 mRNA
CTD
PMID:25596134
NCBI chr 2:25,433,958...25,516,734
Ensembl chr 2:25,433,959...25,516,673
G
Scd
stearoyl-CoA desaturase
multiple interactions decreases expression
ISO EXP
[Metformin co-treated with caffeic acid] results in decreased expression of SCD1 protein; Metformin inhibits the reaction [INS protein results in increased expression of SCD protein] Metformin results in decreased expression of SCD1 mRNA
CTD
PMID:28576465 PMID:31324951 PMID:36764371
NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
G
Scd3
stearoyl-coenzyme A desaturase 3
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of SCD3 mRNA]
CTD
PMID:29095437
NCBI chr 1:243,093,057...243,114,451
Ensembl chr 1:243,078,774...243,114,229
G
Sdf2l1
stromal cell-derived factor 2-like 1
increases expression
EXP
Metformin results in increased expression of SDF2L1 mRNA
CTD
PMID:25596134
NCBI chr11:83,872,659...83,874,902
Ensembl chr11:83,872,659...83,874,902
G
Sdhb
succinate dehydrogenase complex iron sulfur subunit B
multiple interactions
ISO
Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of SDHB mRNA]
CTD
PMID:37337224
NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293
G
Sds
serine dehydratase
decreases expression
EXP
Metformin results in decreased expression of SDS mRNA
CTD
PMID:31324951
NCBI chr12:36,083,226...36,090,540
Ensembl chr12:36,083,229...36,088,203
G
Sec23b
Sec23 homolog B, COPII coat complex component
increases expression
EXP
Metformin results in increased expression of SEC23B mRNA
CTD
PMID:31324951
NCBI chr 3:131,939,011...131,981,489
Ensembl chr 3:131,939,337...131,981,489
G
Sec62
SEC62 homolog, preprotein translocation factor
multiple interactions
EXP
Metformin inhibits the reaction [Glucose results in increased expression of SEC62 protein]
CTD
PMID:34801538
NCBI chr 2:112,570,810...112,598,198
Ensembl chr 2:112,570,819...112,601,814
G
Selenop
selenoprotein P
multiple interactions
EXP
Metformin inhibits the reaction [Dexamethasone results in increased expression of SELENOP mRNA]; Metformin inhibits the reaction [Dexamethasone results in increased secretion of SELENOP protein]; Metformin inhibits the reaction [Glucose results in increased expression of SELENOP mRNA]; Metformin inhibits the reaction [Glucose results in increased secretion of SELENOP protein]
CTD
PMID:19576170
NCBI chr 2:52,498,123...52,508,409
Ensembl chr 2:52,498,339...52,508,852
G
Selp
selectin P
multiple interactions
EXP
Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin] inhibits the reaction [Ovalbumin results in increased expression of SELP protein]]
CTD
PMID:36547818
NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
G
Sephs2
selenophosphate synthetase 2
multiple interactions
EXP
Metformin inhibits the reaction [Dexamethasone results in increased expression of SEPHS2 mRNA]
CTD
PMID:19576170
NCBI chr 1:181,893,146...181,895,464
Ensembl chr 1:181,892,599...181,895,497
G
Serpinc1
serpin family C member 1
increases activity
ISO
Metformin results in increased activity of SERPINC1 protein
CTD
PMID:29458015
NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293
G
Serpine1
serpin family E member 1
multiple interactions
EXP
Metformin inhibits the reaction [Fructose results in increased expression of SERPINE1 protein]
CTD
PMID:25108154
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
G
Sertad1
SERTA domain containing 1
decreases expression
EXP
Metformin results in decreased expression of SERTAD1 mRNA
CTD
PMID:25596134
NCBI chr 1:82,775,692...82,778,961
Ensembl chr 1:82,775,252...82,779,091
G
Sesn1
sestrin 1
decreases expression
EXP
Metformin results in decreased expression of SESN1 mRNA
CTD
PMID:25596134
NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697
G
Sesn2
sestrin 2
multiple interactions decreases expression
ISO EXP
[Metformin co-treated with Rotenone] results in increased expression of SESN2 protein Metformin results in decreased expression of SESN2 mRNA
CTD
PMID:26031332 PMID:31324951
NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
G
Setx
senataxin
decreases expression
EXP
Metformin results in decreased expression of SETX mRNA
CTD
PMID:25596134
NCBI chr 3:12,428,091...12,480,801
Ensembl chr 3:12,427,635...12,480,803
G
Sez6
seizure related 6 homolog
decreases expression
EXP
Metformin results in decreased expression of SEZ6 mRNA
CTD
PMID:31324951
NCBI chr10:62,818,931...62,868,686
Ensembl chr10:62,819,069...62,868,671
G
Sfn
stratifin
increases expression
EXP
Metformin results in increased expression of SFN mRNA
CTD
PMID:25596134
NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314
G
Sgk1
serum/glucocorticoid regulated kinase 1
affects expression
EXP
Metformin affects the expression of SGK1 mRNA
CTD
PMID:31324951
NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
G
Sgk2
serum/glucocorticoid regulated kinase 2
increases expression
EXP
Metformin results in increased expression of SGK2 mRNA
CTD
PMID:31324951
NCBI chr 3:151,644,102...151,669,480
Ensembl chr 3:151,644,102...151,669,480
G
Sh3bp5
SH3-domain binding protein 5
decreases expression
EXP
Metformin results in decreased expression of SH3BP5 mRNA
CTD
PMID:31324951
NCBI chr16:6,583,462...6,678,344
Ensembl chr16:6,583,465...6,698,975
G
Siah2
siah E3 ubiquitin protein ligase 2
decreases expression
EXP
Metformin results in decreased expression of SIAH2 mRNA
CTD
PMID:25596134
NCBI chr 2:142,913,924...142,931,752
Ensembl chr 2:142,914,003...142,931,950
G
Sik1
salt-inducible kinase 1
decreases expression
EXP
Metformin results in decreased expression of SIK1 mRNA
CTD
PMID:25596134 PMID:31324951
NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991
G
Sirt1
sirtuin 1
multiple interactions increases phosphorylation increases expression
ISO EXP
SIRT1 protein affects the reaction [Metformin affects the expression of NAMPT mRNA] Metformin results in increased phosphorylation of SIRT1 protein Metformin results in increased expression of SIRT1 mRNA Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of SIRT1 protein]; Metformin inhibits the reaction [Ethinyl Estradiol results in decreased phosphorylation of SIRT1 protein]; Metformin inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]; SIRT1 mutant form inhibits the reaction [Metformin results in increased expression of PPARGC1A mRNA] Metformin results in increased expression of SIRT1 protein [Niacinamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Metformin; Metformin inhibits the reaction [Fructose results in decreased expression of SIRT1 protein]; Metformin promotes the reaction [Arsenic Trioxide results in increased expression of SIRT1 protein]
CTD
PMID:23090186 PMID:23166782 PMID:23315983 PMID:24428821 PMID:24687991 PMID:25108154 PMID:31332900 PMID:32808185 PMID:34058177 PMID:37337224 More...
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
G
Sirt2
sirtuin 2
increases expression
ISO
Metformin results in increased expression of SIRT2 mRNA; Metformin results in increased expression of SIRT2 protein
CTD
PMID:24687991
NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975
G
Sirt3
sirtuin 3
multiple interactions increases expression decreases expression decreases response to substance
ISO EXP
Metformin inhibits the reaction [GCG protein results in increased expression of SIRT3 mRNA]; SIRT3 promotes the reaction [Metformin inhibits the reaction [Cisplatin affects the localization of SLC2A4 protein]]; SIRT3 protein inhibits the reaction [Metformin results in decreased abundance of Adenosine Triphosphate]; SIRT3 protein promotes the reaction [Metformin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]]; SIRT3 protein promotes the reaction [Metformin inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]]; SIRT3 protein promotes the reaction [Metformin inhibits the reaction [Cisplatin results in increased expression of BAX protein]] Metformin results in increased expression of and results in increased activity of SIRT3 protein [Arsenic Trioxide co-treated with Metformin] results in increased expression of SIRT3 protein; Metformin inhibits the reaction [Cisplatin results in decreased expression of SIRT3 mRNA]; Metformin inhibits the reaction [Cisplatin results in decreased expression of SIRT3 protein] Metformin results in increased expression of SIRT3 protein Metformin results in decreased expression of SIRT3 mRNA; Metformin results in decreased expression of SIRT3 protein SIRT3 protein results in decreased susceptibility to Metformin
CTD
PMID:23166782 PMID:24687991 PMID:30385301 PMID:33147367 PMID:36800006
NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808
G
Sirt4
sirtuin 4
increases expression
ISO
Metformin results in increased expression of SIRT4 mRNA
CTD
PMID:24687991
NCBI chr12:41,125,533...41,139,440
Ensembl chr12:41,131,262...41,139,439
G
Sirt5
sirtuin 5
decreases expression
ISO
Metformin results in decreased expression of SIRT5 protein
CTD
PMID:24687991
NCBI chr17:21,310,028...21,337,137
Ensembl chr17:21,310,028...21,337,101
G
Sirt7
sirtuin 7
decreases expression
ISO
Metformin results in decreased expression of SIRT7 mRNA
CTD
PMID:24687991
NCBI chr10:105,896,476...105,903,301
Ensembl chr10:105,896,476...105,903,172
G
Siva1
SIVA1, apoptosis-inducing factor
decreases expression
EXP
Metformin results in decreased expression of SIVA1 mRNA
CTD
PMID:25596134
NCBI chr 6:131,705,323...131,709,697
Ensembl chr 6:131,705,323...131,709,690
G
Skp2
S-phase kinase associated protein 2
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of SKP2 mRNA]
CTD
PMID:29095437
NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338
G
Slc10a1
solute carrier family 10 member 1
decreases expression multiple interactions
ISO
Metformin results in decreased expression of SLC10A1 mRNA; Metformin results in decreased expression of SLC10A1 protein [Ethinyl Estradiol co-treated with Metformin] results in decreased expression of SLC10A1 mRNA; [Metformin co-treated with Ethinyl Estradiol] results in decreased expression of SLC10A1 protein
CTD
PMID:34058177
NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
G
Slc10a2
solute carrier family 10 member 2
multiple interactions increases expression
ISO
Metformin inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLC10A2 protein] Metformin results in increased expression of SLC10A2 protein
CTD
PMID:34058177
NCBI chr16:84,386,528...84,409,475
Ensembl chr16:84,374,862...84,409,475
G
Slc12a8
solute carrier family 12, member 8
increases expression
EXP
Metformin results in increased expression of SLC12A8 mRNA
CTD
PMID:25596134
NCBI chr11:67,116,876...67,266,548
Ensembl chr11:67,116,877...67,266,834
G
Slc15a1
solute carrier family 15 member 1
multiple interactions increases expression
ISO
Metformin inhibits the reaction [rosiglitazone results in increased expression of and results in increased activity of SLC15A1 protein]; Metformin results in decreased activity of and results in decreased expression of SLC15A1 protein Metformin results in increased expression of SLC15A1 mRNA Metformin inhibits the reaction [rosiglitazone results in increased activity of SLC15A1 protein]
CTD
PMID:22108913
NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545
G
Slc16a10
solute carrier family 16 member 10
decreases expression
EXP
Metformin results in decreased expression of SLC16A10 mRNA
CTD
PMID:31324951
NCBI chr20:43,454,819...43,567,839
Ensembl chr20:43,459,709...43,567,839
G
Slc16a6
solute carrier family 16, member 6
increases expression
EXP
Metformin results in increased expression of SLC16A6 mRNA
CTD
PMID:25596134
NCBI chr10:94,424,377...94,447,482
Ensembl chr10:94,426,244...94,448,779
G
Slc19a2
solute carrier family 19 member 2
decreases expression
EXP
Metformin results in decreased expression of SLC19A2 mRNA
CTD
PMID:31324951
NCBI chr13:76,601,975...76,616,175
Ensembl chr13:76,601,900...76,616,172
G
Slc19a3
solute carrier family 19 member 3
multiple interactions increases uptake
ISO
Amprolium inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Chloroquine inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Famotidine inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Metformin inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Metformin inhibits the reaction [SLC19A3 protein results in increased uptake of Thiamine]; Phenformin inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Verapamil inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]
CTD
PMID:26528626
NCBI chr 9:84,275,722...84,299,368
Ensembl chr 9:84,277,024...84,299,337
G
Slc1a4
solute carrier family 1 member 4
increases expression
EXP
Metformin results in increased expression of SLC1A4 mRNA
CTD
PMID:25596134
NCBI chr14:94,530,801...94,560,190
Ensembl chr14:94,529,084...94,560,418
G
Slc22a1
solute carrier family 22 member 1
multiple interactions increases uptake increases response to substance
ISO
Imipramine inhibits the reaction [SLC22A1 protein results in increased uptake of Metformin]; Metformin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] SLC22A1 protein results in increased susceptibility to Metformin
CTD
PMID:16141367 PMID:20956498 PMID:25106415
NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
G
Slc22a2
solute carrier family 22 member 2
multiple interactions increases transport increases uptake decreases transport affects transport
ISO EXP
Bisoprolol inhibits the reaction [SLC22A2 protein results in increased uptake of Metformin]; carvedilol inhibits the reaction [SLC22A2 protein results in increased uptake of Metformin]; Metformin inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Metoprolol inhibits the reaction [SLC22A2 protein results in increased uptake of Metformin]; Ondansetron inhibits the reaction [SLC22A2 protein results in increased uptake of Metformin]; Phenoxybenzamine inhibits the reaction [SLC22A2 protein affects the transport of Metformin]; Propranolol inhibits the reaction [SLC22A2 protein results in increased uptake of Metformin] SLC22A2 protein results in increased transport of Metformin SLC22A2 protein mutant form results in decreased transport of Metformin
CTD
PMID:16141367 PMID:18230276 PMID:18728938 PMID:19740083 PMID:24001450 PMID:32305507 More...
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
G
Slc22a3
solute carrier family 22 member 3
multiple interactions increases uptake
ISO EXP
carvedilol inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin]; Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin]; Imipramine inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin]; Metformin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Verapamil inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin] [1-Methyl-4-phenylpyridinium results in decreased activity of [SLC22A3 protein co-treated with SLC47A1 protein]] which results in decreased transport of Metformin
CTD
PMID:16141367 PMID:21697722 PMID:23562376
NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
G
Slc22a4
solute carrier family 22 member 4
decreases expression multiple interactions
EXP ISO
Metformin results in decreased expression of SLC22A4 mRNA Metformin inhibits the reaction [SLC22A4 protein results in increased abundance of Doxorubicin]
CTD
PMID:31324951 PMID:37453608 PMID:38364893
NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720
G
Slc22a5
solute carrier family 22 member 5
increases expression multiple interactions
EXP ISO
Metformin results in increased expression of SLC22A5 mRNA Metformin inhibits the reaction [SLC22A5 protein results in increased abundance of Doxorubicin]
CTD
PMID:31324951 PMID:37453608 PMID:38364893
NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
G
Slc25a20
solute carrier family 25 member 20
decreases expression
EXP
Metformin results in decreased expression of SLC25A20 mRNA
CTD
PMID:25596134
NCBI chr 8:109,365,056...109,386,512
Ensembl chr 8:109,365,002...109,386,512
G
Slc25a37
solute carrier family 25 member 37
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of SLC25A37 mRNA]
CTD
PMID:29095437
NCBI chr15:44,534,280...44,576,697
Ensembl chr15:44,536,727...44,577,199
G
Slc25a47
solute carrier family 25, member 47
increases expression
EXP
Metformin results in increased expression of SLC25A47 mRNA
CTD
PMID:31324951
NCBI chr 6:127,767,365...127,773,000
Ensembl chr 6:127,767,305...127,773,005
G
Slc29a4
solute carrier family 29 member 4
multiple interactions
ISO
Metformin inhibits the reaction [SLC29A4 protein results in increased abundance of Doxorubicin]
CTD
PMID:37453608
NCBI chr12:11,853,540...11,884,660
Ensembl chr12:11,853,540...11,874,834
G
Slc2a2
solute carrier family 2 member 2
increases response to substance multiple interactions increases phosphorylation
ISO
SLC2A2 intron SNP results in increased susceptibility to Metformin Metformin inhibits the reaction [INS protein results in decreased expression of SLC2A2 protein] Metformin results in increased phosphorylation of SLC2A2 protein
CTD
PMID:26835874 PMID:27500523 PMID:36764371
NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
G
Slc2a4
solute carrier family 2 member 4
multiple interactions decreases expression increases expression
ISO EXP
Metformin affects the reaction [Testosterone results in decreased expression of SLC2A4]; Metformin inhibits the reaction [INS protein results in decreased expression of SLC2A4 protein] Metformin inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased expression of SLC2A4 protein]; SIRT3 promotes the reaction [Metformin inhibits the reaction [Cisplatin affects the localization of SLC2A4 protein]] Metformin results in decreased expression of SLC2A4 mRNA Metformin results in increased expression of SLC2A4 mRNA; Metformin results in increased expression of SLC2A4 protein Metformin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of SLC2A4 protein]; Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of SLC2A4 protein]; Metformin inhibits the reaction [Cisplatin affects the localization of SLC2A4 protein]; Metformin inhibits the reaction [Letrozole results in decreased expression of SLC2A4 mRNA]
CTD
PMID:15864539 PMID:18322300 PMID:19080170 PMID:19328476 PMID:20724125 PMID:21870829 PMID:23457588 PMID:29991592 PMID:30256492 PMID:30914352 PMID:31743741 PMID:32298659 PMID:36800006 More...
NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
G
Slc2a5
solute carrier family 2 member 5
increases expression
EXP
Metformin results in increased expression of SLC2A5 mRNA
CTD
PMID:31324951
NCBI chr 5:160,583,055...160,609,994
Ensembl chr 5:160,583,234...160,611,106
G
Slc3a2
solute carrier family 3 member 2
increases expression
EXP
Metformin results in increased expression of SLC3A2 mRNA
CTD
PMID:25596134
NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931
G
Slc41a3
solute carrier family 41, member 3
decreases expression
EXP
Metformin results in decreased expression of SLC41A3 mRNA
CTD
PMID:31324951
NCBI chr 4:123,109,555...123,154,766
Ensembl chr 4:123,112,748...123,154,766
G
Slc46a3
solute carrier family 46, member 3
decreases expression
EXP
Metformin results in decreased expression of SLC46A3 mRNA
CTD
PMID:31324951
NCBI chr12:7,140,610...7,157,093
Ensembl chr12:7,140,668...7,157,092
G
Slc47a1
solute carrier family 47 member 1
affects abundance decreases uptake multiple interactions increases secretion increases uptake
ISO EXP
SLC47A1 protein affects the abundance of Metformin SLC47A1 protein polymorphism results in decreased uptake of Metformin [1-Methyl-4-phenylpyridinium results in decreased activity of [SLC22A3 protein co-treated with SLC47A1 protein]] which results in decreased transport of Metformin SLC47A1 protein results in increased secretion of Metformin SLC47A1 protein results in increased uptake of Metformin Cadmium inhibits the reaction [SLC47A1 protein results in increased uptake of Metformin]; Ondansetron inhibits the reaction [SLC47A1 protein results in increased uptake of Metformin] Cadmium inhibits the reaction [SLC47A1 protein results in increased uptake of Metformin]; Metformin inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Ondansetron inhibits the reaction [SLC47A1 protein results in increased uptake of Metformin]; Pyrimethamine inhibits the reaction [SLC47A1 protein results in increased uptake of Metformin]
CTD
PMID:19172157 PMID:21991918 PMID:22419765 PMID:23562376 PMID:24001450 PMID:27871888 More...
NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
G
Slc47a2
solute carrier family 47 member 2
increases uptake multiple interactions
ISO
SLC47A2 protein results in increased uptake of Metformin Cadmium inhibits the reaction [SLC47A2 protein results in increased uptake of Metformin]; Metformin inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Ondansetron inhibits the reaction [SLC47A2 protein results in increased uptake of Metformin]
CTD
PMID:22419765 PMID:24001450 PMID:27871888
NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
G
Slc4a1
solute carrier family 4 member 1 (Diego blood group)
decreases expression
EXP
Metformin results in decreased expression of SLC4A1 mRNA
CTD
PMID:31324951
NCBI chr10:87,306,865...87,323,132
Ensembl chr10:87,306,872...87,323,117
G
Slc6a6
solute carrier family 6 member 6
increases expression
EXP
Metformin results in increased expression of SLC6A6 mRNA
CTD
PMID:25596134
NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875
G
Slc6a9
solute carrier family 6 member 9
increases expression
EXP
Metformin results in increased expression of SLC6A9 mRNA
CTD
PMID:25596134 PMID:31324951
NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728
G
Slc7a1
solute carrier family 7 member 1
increases expression
EXP
Metformin results in increased expression of SLC7A1 mRNA
CTD
PMID:25596134
NCBI chr12:6,628,288...6,703,849
Ensembl chr12:6,628,007...6,703,849
G
Slc7a11
solute carrier family 7 member 11
increases expression
EXP
Metformin results in increased expression of SLC7A11 mRNA
CTD
PMID:25596134
NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
G
Slc7a5
solute carrier family 7 member 5
increases expression
EXP
Metformin results in increased expression of SLC7A5 mRNA
CTD
PMID:25596134
NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823
G
Slco1a4
solute carrier organic anion transporter family, member 1a4
decreases expression multiple interactions increases expression
EXP ISO
Metformin results in decreased expression of SLCO1A2 mRNA [Ethinyl Estradiol co-treated with Metformin] results in decreased expression of SLCO1A4 mRNA Metformin results in increased expression of SLCO1A4 mRNA
CTD
PMID:19022234 PMID:34058177
NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
G
Slco2b1
solute carrier organic anion transporter family, member 2b1
decreases expression
EXP ISO
Metformin results in decreased expression of SLCO2B1 mRNA
CTD
PMID:25596134
NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353
G
Smagp
small cell adhesion glycoprotein
decreases expression
EXP
Metformin results in decreased expression of SMAGP mRNA
CTD
PMID:31324951
NCBI chr 7:131,720,260...131,738,711
Ensembl chr 7:131,718,740...131,738,691
G
Snai2
snail family transcriptional repressor 2
increases expression
EXP
Metformin results in increased expression of SNAI2 mRNA
CTD
PMID:31324951
NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200
G
Snora30
small nucleolar RNA, H/ACA box 30
decreases expression
EXP
Metformin results in decreased expression of SNORA30 mRNA
CTD
PMID:31324951
NCBI chr 1:182,139,388...182,139,521
Ensembl chr 1:182,139,388...182,139,521
G
Snord13
small nucleolar RNA, C/D box 13
decreases expression
EXP
Metformin results in decreased expression of SNORD13 mRNA
CTD
PMID:31324951
NCBI chr16:60,988,909...60,989,013
Ensembl chr16:60,988,909...60,989,013
G
Sod1
superoxide dismutase 1
multiple interactions
EXP ISO
Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of SOD1 protein] Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of SOD1 protein]
CTD
PMID:35085591 PMID:36999408 PMID:37120126
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
G
Sod2
superoxide dismutase 2
increases expression multiple interactions
ISO
Metformin results in increased expression of SOD2 mRNA PRKAA1 protein affects the reaction [Metformin results in increased expression of SOD2 mRNA]
CTD
PMID:16380484
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
G
Son
SON DNA and RNA binding protein
decreases expression
EXP
Metformin results in decreased expression of SON mRNA
CTD
PMID:25596134
NCBI chr11:30,850,890...30,923,167
Ensembl chr11:30,892,005...30,923,167
G
Sorl1
sortilin related receptor 1
decreases expression
EXP
Metformin results in decreased expression of SORL1 mRNA
CTD
PMID:25596134
NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513
G
Sp1
Sp1 transcription factor
multiple interactions decreases expression
ISO
Metformin inhibits the reaction [SP1 protein results in increased expression of AHR protein] Metformin results in decreased expression of SP1 protein
CTD
PMID:25110054 PMID:26317792
NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
G
Sp3
Sp3 transcription factor
decreases expression
ISO
Metformin results in decreased expression of SP3 protein
CTD
PMID:26317792
NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342
G
Sp4
Sp4 transcription factor
decreases expression
ISO
Metformin results in decreased expression of SP4 protein
CTD
PMID:26317792
NCBI chr 6:139,187,458...139,252,741
Ensembl chr 6:139,192,147...139,252,126
G
Sp7
Sp7 transcription factor
multiple interactions
ISO
Metformin inhibits the reaction [BMP2 protein results in increased expression of SP7 mRNA]; Metformin inhibits the reaction [BMP2 protein results in increased expression of SP7 protein]
CTD
PMID:37409753
NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847
G
Spsb1
splA/ryanodine receptor domain and SOCS box containing 1
increases expression
EXP
Metformin results in increased expression of SPSB1 mRNA
CTD
PMID:25596134
NCBI chr 5:160,358,292...160,418,541
Ensembl chr 5:160,358,308...160,418,468
G
Sqstm1
sequestosome 1
increases expression multiple interactions decreases expression
EXP ISO
Metformin results in increased expression of SQSTM1 mRNA Metformin inhibits the reaction [Blood Glucose results in decreased expression of SQSTM1 protein] Metformin inhibits the reaction [Dietary Fats results in increased expression of SQSTM1 protein] Metformin results in decreased expression of SQSTM1 protein [Simvastatin co-treated with Metformin] results in decreased expression of SQSTM1 protein; Chloroquine inhibits the reaction [[Simvastatin co-treated with Metformin] results in decreased expression of SQSTM1 protein]; Hydroxychloroquine inhibits the reaction [Metformin inhibits the reaction [Galactose results in increased expression of SQSTM1 protein]]; Metformin inhibits the reaction [Galactose results in increased expression of SQSTM1 protein]; Metformin inhibits the reaction [Oleic Acid results in increased expression of SQSTM1 protein]; plantamajoside promotes the reaction [Metformin results in decreased expression of SQSTM1 protein]
CTD
PMID:25412314 PMID:25596134 PMID:29426000 PMID:33021114 PMID:35350904 PMID:36592823 More...
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
G
Srd5a3
steroid 5 alpha-reductase 3
decreases expression
EXP
Metformin results in decreased expression of SRD5A3 mRNA
CTD
PMID:25596134
NCBI chr14:32,046,408...32,060,796
Ensembl chr14:32,046,408...32,060,747
G
Srebf1
sterol regulatory element binding transcription factor 1
multiple interactions decreases expression
ISO EXP
[Metformin co-treated with caffeic acid] results in decreased expression of SREBF1 protein; Metformin inhibits the reaction [[cyhalothrin co-treated with Oleic Acid] results in increased expression of SREBF1 protein]; Metformin inhibits the reaction [INS protein results in increased expression of SREBF1 protein] Metformin results in decreased expression of SREBF1 mRNA Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SREBF1 mRNA]; Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SREBF1 protein]
CTD
PMID:28576465 PMID:31100278 PMID:31324951 PMID:36529352 PMID:36764371
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
G
Srebf2
sterol regulatory element binding transcription factor 2
multiple interactions
ISO
Buthionine Sulfoximine inhibits the reaction [Metformin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of SREBF2 protein]]; Metformin inhibits the reaction [AGT protein results in increased cleavage of and affects the localization of SREBF2 protein]; Metformin inhibits the reaction [AGT protein results in increased expression of SREBF2 protein]; Metformin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of SREBF2 protein] Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased cleavage of SREBF2 protein]
CTD
PMID:29499335
NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
G
Srm
spermidine synthase
increases expression
EXP
Metformin results in increased expression of SRM mRNA
CTD
PMID:31324951
NCBI chr 5:159,025,875...159,029,076
Ensembl chr 5:159,025,873...159,029,405
G
Srr
serine racemase
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of SRR mRNA]
CTD
PMID:29095437
NCBI chr10:59,769,563...59,786,688
Ensembl chr10:59,769,571...59,787,011
G
Sst
somatostatin
increases expression
ISO
Metformin results in increased expression of SST mRNA
CTD
PMID:23457588
NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173
G
St3gal2
ST3 beta-galactoside alpha-2,3-sialyltransferase 2
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of ST3GAL2 mRNA]
CTD
PMID:29095437
NCBI chr19:38,888,851...38,939,874
Ensembl chr19:38,923,999...38,939,869
G
Star
steroidogenic acute regulatory protein
multiple interactions
EXP
Metformin inhibits the reaction [FSHB protein results in increased expression of STAR protein]; PRKAA1 gene mutant form inhibits the reaction [Metformin inhibits the reaction [FSHB protein results in increased expression of STAR protein]]
CTD
PMID:16760380
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
G
Stk11
serine/threonine kinase 11
multiple interactions
ISO
Metformin inhibits the reaction [2-chloroethyl ethyl sulfide results in decreased phosphorylation of STK11 protein]
CTD
PMID:37481222
NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315
G
Strbp
spermatid perinuclear RNA binding protein
increases expression
EXP
Metformin results in increased expression of STRBP mRNA
CTD
PMID:25596134
NCBI chr 3:21,328,310...21,467,753
Ensembl chr 3:21,337,855...21,414,949
G
Sulf2
sulfatase 2
decreases expression
EXP
Metformin results in decreased expression of SULF2 mRNA
CTD
PMID:25596134
NCBI chr 3:154,822,079...154,904,566
Ensembl chr 3:154,822,085...154,904,415
G
Sult4a1
sulfotransferase family 4A, member 1
increases expression
EXP
Metformin results in increased expression of SULT4A1 mRNA
CTD
PMID:31324951
NCBI chr 7:115,216,066...115,240,156
Ensembl chr 7:115,216,066...115,240,085
G
Taf15
TATA-box binding protein associated factor 15
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of TAF15 mRNA]
CTD
PMID:29095437
NCBI chr10:68,272,921...68,304,951
Ensembl chr10:68,272,969...68,304,949
G
Taldo1
transaldolase 1
decreases expression
EXP
Metformin results in decreased expression of TALDO1 mRNA
CTD
PMID:25596134
NCBI chr 1:196,493,634...196,503,965
Ensembl chr 1:196,493,589...196,503,974
G
Tanc2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
decreases expression
EXP
Metformin results in decreased expression of TANC2 mRNA
CTD
PMID:31324951
NCBI chr10:90,553,124...90,873,477
Ensembl chr10:90,553,002...90,868,756
G
Taok1
TAO kinase 1
increases expression
EXP
Metformin results in increased expression of TAOK1 mRNA
CTD
PMID:25596134
NCBI chr10:62,373,072...62,465,295
Ensembl chr10:62,381,404...62,465,766
G
Tbc1d4
TBC1 domain family, member 4
multiple interactions
ISO
Metformin inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of TBC1D4 protein]
CTD
PMID:31743741
NCBI chr15:78,256,030...78,434,168
Ensembl chr15:78,257,121...78,434,265
G
Tbccd1
TBCC domain containing 1
increases expression
EXP
Metformin results in increased expression of TBCCD1 mRNA
CTD
PMID:31324951
NCBI chr11:78,168,386...78,205,314
Ensembl chr11:78,168,388...78,205,523
G
Tbx3
T-box transcription factor 3
increases expression
EXP
Metformin results in increased expression of TBX3 mRNA
CTD
PMID:31324951
NCBI chr12:36,879,924...36,894,849
Ensembl chr12:36,881,445...36,893,708
G
Tceal7
transcription elongation factor A like 7
increases expression
EXP
Metformin results in increased expression of TCEAL7 mRNA
CTD
PMID:31324951
NCBI chr X:99,228,405...99,230,551
Ensembl chr X:99,228,458...99,230,543
G
Tcp11l2
t-complex 11 like 2
decreases expression
EXP
Metformin results in decreased expression of TCP11L2 mRNA
CTD
PMID:31324951
NCBI chr 7:19,150,241...19,185,135
Ensembl chr 7:19,150,252...19,185,095
G
Tdo2
tryptophan 2,3-dioxygenase
multiple interactions decreases expression
ISO
Metformin inhibits the reaction [Dexamethasone results in increased expression of TDO2 mRNA]; Metformin inhibits the reaction [Dexamethasone results in increased expression of TDO2 protein] Metformin results in decreased expression of TDO2 mRNA; Metformin results in decreased expression of TDO2 protein
CTD
PMID:25110054
NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511
G
Telo2
telomere maintenance 2
multiple interactions increases expression
ISO
[Metformin co-treated with Pioglitazone] results in increased expression of TELO2 mRNA Metformin results in increased expression of TELO2 mRNA
CTD
PMID:32589349
NCBI chr10:14,120,491...14,135,729
Ensembl chr10:14,120,818...14,135,698
G
Tfam
transcription factor A, mitochondrial
increases expression
ISO
Metformin results in increased expression of TFAM mRNA
CTD
PMID:16380484
NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
G
Tfe3
transcription factor binding to IGHM enhancer 3
increases expression
EXP
Metformin results in increased expression of TFE3 mRNA
CTD
PMID:25596134
NCBI chr X:14,729,547...14,742,830
Ensembl chr X:14,729,550...14,742,571
G
Tfrc
transferrin receptor
increases expression
EXP
Metformin results in increased expression of TFRC mRNA
CTD
PMID:31324951
NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
G
Tgfb1
transforming growth factor, beta 1
increases expression multiple interactions
EXP ISO
Metformin results in increased expression of TGFB1 mRNA Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of TGFB1 mRNA]; Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of TGFB1 protein]; Metformin inhibits the reaction [Folic Acid results in increased expression of TGFB1 mRNA]; Metformin inhibits the reaction [Folic Acid results in increased expression of TGFB1 protein] dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TGFB1 protein]]; Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TGFB1 protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TGFB1 protein]; Metformin inhibits the reaction [Blood Glucose results in increased expression of TGFB1 protein]
CTD
PMID:19022234 PMID:29380373 PMID:30551545 PMID:33021114 PMID:37120126
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
G
Th
tyrosine hydroxylase
multiple interactions
EXP
Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TH protein]
CTD
PMID:35085591
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
G
Thrsp
thyroid hormone responsive
increases expression
EXP
Metformin results in increased expression of THRSP mRNA
CTD
PMID:31324951
NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075
G
Timm17b
translocase of inner mitochondrial membrane 17b
affects expression
EXP
Metformin affects the expression of TIMM17B mRNA
CTD
PMID:25596134
NCBI chr X:14,596,330...14,603,491
Ensembl chr X:14,594,577...14,603,416
G
Timp3
TIMP metallopeptidase inhibitor 3
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of TIMP3 mRNA]
CTD
PMID:29095437
NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839
G
Tiparp
TCDD-inducible poly(ADP-ribose) polymerase
increases expression
EXP
Metformin results in increased expression of TIPARP mRNA
CTD
PMID:25596134
NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327
G
Tkfc
triokinase and FMN cyclase
increases expression
EXP
Metformin results in increased expression of TKFC mRNA
CTD
PMID:31324951
NCBI chr 1:207,238,230...207,253,035
Ensembl chr 1:207,236,557...207,252,737
G
Tlr1
toll-like receptor 1
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in increased expression of TLR1 mRNA
CTD
PMID:29309887
NCBI chr14:43,384,127...43,396,765
Ensembl chr14:43,384,932...43,397,125
G
Tlr2
toll-like receptor 2
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in increased expression of TLR2 mRNA
CTD
PMID:29309887
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
G
Tlr3
toll-like receptor 3
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in increased expression of TLR3 mRNA
CTD
PMID:29309887
NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545
G
Tlr4
toll-like receptor 4
multiple interactions
EXP ISO
Metformin affects the reaction [Dehydroepiandrosterone results in increased expression of TLR4 protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of TLR4 mRNA]; Metformin inhibits the reaction [Isoproterenol results in increased expression of TLR4 mRNA] [Paclitaxel co-treated with Metformin] results in decreased expression of TLR4 mRNA
CTD
PMID:24842192 PMID:27634381 PMID:29309887
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
G
Tlr5
toll-like receptor 5
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in increased expression of TLR5 mRNA
CTD
PMID:29309887
NCBI chr13:94,634,778...94,658,992
Ensembl chr13:94,634,801...94,657,738
G
Tlr6
toll-like receptor 6
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in increased expression of TLR6 mRNA
CTD
PMID:29309887
NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685
G
Tlr7
toll-like receptor 7
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in increased expression of TLR7 mRNA
CTD
PMID:29309887
NCBI chr X:27,027,380...27,054,309
Ensembl chr X:27,027,425...27,054,754
G
Tlr8
toll-like receptor 8
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in increased expression of TLR8 mRNA
CTD
PMID:29309887
NCBI chr X:27,091,780...27,116,092
Ensembl chr X:27,091,778...27,116,549
G
Tmem140
transmembrane protein 140
decreases expression
EXP
Metformin results in decreased expression of TMEM140 mRNA
CTD
PMID:31324951
NCBI chr 4:63,536,477...63,547,478
Ensembl chr 4:63,536,168...63,548,455
G
Tmem71
transmembrane protein 71
decreases expression
EXP
Metformin results in decreased expression of TMEM71 mRNA
CTD
PMID:31324951
NCBI chr 7:98,276,975...98,323,161
Ensembl chr 7:98,276,975...98,315,858
G
Tmod4
tropomodulin 4
increases expression
EXP
Metformin results in increased expression of TMOD4 mRNA
CTD
PMID:31324951
NCBI chr 2:182,695,709...182,700,540
Ensembl chr 2:182,695,709...182,700,540
G
Tnf
tumor necrosis factor
decreases expression multiple interactions increases expression
EXP ISO
Metformin results in decreased expression of TNF mRNA Metformin co-treated with metformin hydrochloride co-treated with N(gamma)-nitro-L-arginine methyl ester inhibits the reaction [pre-eclampsia increases expression of Tnf protein in blood serum] [Metformin co-treated with Rosiglitazone co-treated with Valsartan co-treated with Ezetimibe] inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; [Metformin co-treated with Rosiglitazone co-treated with Valsartan] inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; [Metformin co-treated with Rosiglitazone] promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TNF protein]]; Metformin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TNF protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TNF protein]; Metformin inhibits the reaction [Chlorpyrifos results in increased expression of TNF protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of TNF protein]; Metformin inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; Metformin inhibits the reaction [Fructose results in increased expression of TNF protein]; Metformin inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of TNF protein]; Metformin inhibits the reaction [Isoproterenol results in increased expression of TNF mRNA]; Metformin inhibits the reaction [Methamphetamine results in increased expression of TNF protein]; Metformin inhibits the reaction [Palmitic Acid results in increased expression of TNF mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin] inhibits the reaction [Ovalbumin results in increased expression of TNF protein]] dorsomorphin inhibits the reaction [Metformin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of TNF mRNA]; Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of TNF protein]; Metformin inhibits the reaction [AGT protein results in increased secretion of TNF protein]; Metformin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Metformin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; Metformin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Metformin inhibits the reaction [Olanzapine results in increased expression of TNF protein]; Metformin inhibits the reaction [Rotenone results in increased expression of TNF mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of TNF protein] [Paclitaxel co-treated with Metformin] results in decreased expression of TNF mRNA; Metformin inhibits the reaction [TNF protein results in increased expression of ABCB1 mRNA]; Metformin inhibits the reaction [TNF protein results in increased expression of ABCB1 protein] Metformin results in increased expression of TNF mRNA; Metformin results in increased expression of TNF protein
CTD RGD
PMID:16865780 PMID:19022234 PMID:20869956 PMID:21054339 PMID:21457706 PMID:21870829 PMID:24717679 PMID:24842192 PMID:25108154 PMID:26818447 PMID:27634381 PMID:28096963 PMID:28259689 PMID:29309887 PMID:29499335 PMID:29859833 PMID:30551545 PMID:30742852 PMID:32189544 PMID:32652086 PMID:33639173 PMID:35085591 PMID:35448458 PMID:36547818 PMID:37120126 PMID:31203154 More...
RGD:213230155
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Tnfaip8
TNF alpha induced protein 8
increases expression
EXP
Metformin results in increased expression of TNFAIP8 mRNA
CTD
PMID:25596134
NCBI chr18:43,183,854...43,299,512
Ensembl chr18:43,183,916...43,299,517
G
Tnfrsf10b
TNF receptor superfamily member 10b
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of TNFRSF10A mRNA
CTD
PMID:29309887
NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467
G
Tnfrsf1a
TNF receptor superfamily member 1A
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of TNFRSF1A mRNA
CTD
PMID:29309887
NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
G
Tnfrsf21
TNF receptor superfamily member 21
increases expression multiple interactions
EXP ISO
Metformin results in increased expression of TNFRSF21 mRNA [Paclitaxel co-treated with Metformin] results in decreased expression of TNFRSF21 mRNA
CTD
PMID:25596134 PMID:29309887
NCBI chr 9:17,879,156...17,954,085
Ensembl chr 9:17,879,156...17,954,085
G
Tnfrsf22
tumor necrosis factor receptor superfamily, member 22
increases expression
EXP
Metformin results in increased expression of TNFRSF10B mRNA
CTD
PMID:25596134
NCBI chr 1:198,840,452...198,860,713
Ensembl chr 1:198,840,453...198,856,309
G
Tnfrsf25
TNF receptor superfamily member 25
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in increased expression of TNFRSF25 mRNA
CTD
PMID:29309887
NCBI chr 5:162,621,669...162,626,341
Ensembl chr 5:162,622,075...162,626,341
G
Tnfrsf9
TNF receptor superfamily member 9
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of TNFRSF9 mRNA
CTD
PMID:29309887
NCBI chr 5:161,381,662...161,408,003
Ensembl chr 5:161,381,662...161,408,000
G
Tnfsf12
TNF superfamily member 12
multiple interactions
ISO
Metformin inhibits the reaction [PPARGC1A protein results in decreased expression of TNFSF12 mRNA]
CTD
PMID:22117073
NCBI chr10:54,403,870...54,413,213
Ensembl chr10:54,403,870...54,413,213
G
Tp53
tumor protein p53
affects activity decreases expression multiple interactions
EXP ISO
Metformin affects the activity of TP53 protein Metformin results in decreased expression of TP53 protein [Hydrogen Peroxide co-treated with Metformin] results in decreased expression of TP53 protein; [Metformin co-treated with NVP-BKM120] results in increased expression of TP53 mRNA; [Metformin co-treated with NVP-BKM120] results in increased expression of TP53 protein Metformin increases expression and phosphorylation of TP53 protein in epithelial cell of alveolus of lung
CTD RGD
PMID:25596134 PMID:29185360 PMID:38479708 PMID:23632475
RGD:150404268
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
G
Tp53inp1
tumor protein p53 inducible nuclear protein 1
increases expression decreases expression
EXP ISO
Metformin results in increased expression of TP53INP1 mRNA Metformin results in decreased expression of TP53INP1 mRNA
CTD
PMID:25596134
NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968
G
Tpcn1
two pore segment channel 1
decreases expression
EXP
Metformin results in decreased expression of TPCN1 mRNA
CTD
PMID:25596134
NCBI chr12:35,972,813...36,029,632
Ensembl chr12:35,972,846...36,029,626
G
Tradd
TNFRSF1A-associated via death domain
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of TRADD mRNA
CTD
PMID:29309887
NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638
G
Traf2
Tnf receptor-associated factor 2
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of TRAF2 mRNA
CTD
PMID:29309887
NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538
G
Traf3
Tnf receptor-associated factor 3
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of TRAF3 mRNA
CTD
PMID:29309887
NCBI chr 6:130,199,696...130,307,168
Ensembl chr 6:130,206,484...130,305,481
G
Traf4
Tnf receptor associated factor 4
multiple interactions
ISO
[Paclitaxel co-treated with Metformin] results in decreased expression of TRAF4 mRNA
CTD
PMID:29309887
NCBI chr10:63,054,169...63,060,284
Ensembl chr10:63,054,181...63,060,284
G
Trafd1
TRAF type zinc finger domain containing 1
decreases expression
EXP
Metformin results in decreased expression of TRAFD1 mRNA
CTD
PMID:25596134
NCBI chr12:35,165,606...35,179,525
Ensembl chr12:35,165,606...35,179,525
G
Trim21
tripartite motif-containing 21
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of TRIM21 mRNA]
CTD
PMID:29095437
NCBI chr 1:156,964,896...156,987,504
Ensembl chr 1:156,964,913...156,987,440
G
Trim39
tripartite motif-containing 39
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of TRIM39 mRNA]
CTD
PMID:29095437
NCBI chr20:2,003,320...2,017,175
Ensembl chr20:1,983,533...2,020,117
G
Trpc1
transient receptor potential cation channel, subfamily C, member 1
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of TRPC1 mRNA]
CTD
PMID:29095437
NCBI chr 8:96,263,322...96,314,220
Ensembl chr 8:96,263,329...96,314,276
G
Tsku
tsukushi, small leucine rich proteoglycan
affects expression
EXP
Metformin affects the expression of TSKU mRNA
CTD
PMID:31324951
NCBI chr 1:152,660,259...152,671,682
Ensembl chr 1:152,656,693...152,672,588
G
Tspan12
tetraspanin 12
decreases expression
EXP
Metformin results in decreased expression of TSPAN12 mRNA
CTD
PMID:25596134
NCBI chr 4:50,313,768...50,389,246
Ensembl chr 4:50,313,772...50,389,246
G
Txnip
thioredoxin interacting protein
multiple interactions
ISO
Hydroxychloroquine inhibits the reaction [Metformin inhibits the reaction [Galactose results in increased expression of TXNIP protein]]; Metformin inhibits the reaction [Galactose results in increased expression of TXNIP protein] Metformin inhibits the reaction [Glucose results in increased expression of TXNIP mRNA]
CTD
PMID:29426000 PMID:31974165
NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
G
Txnrd1
thioredoxin reductase 1
increases expression
EXP
Metformin results in increased expression of TXNRD1 mRNA
CTD
PMID:25596134
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
G
Uap1l1
UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of UAP1L1 mRNA]
CTD
PMID:29095437
NCBI chr 3:8,172,335...8,180,505
Ensembl chr 3:8,173,216...8,180,443
G
Ube2b
ubiquitin-conjugating enzyme E2B
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of UBE2B mRNA]
CTD
PMID:29095437
NCBI chr10:36,248,434...36,263,379
Ensembl chr10:36,248,438...36,264,665
G
Ube2g2
ubiquitin-conjugating enzyme E2G 2
decreases expression
EXP
Metformin results in decreased expression of UBE2G2 mRNA
CTD
PMID:25596134
NCBI chr20:10,983,734...11,005,468
Ensembl chr20:10,983,742...11,005,447
G
Ucp2
uncoupling protein 2
increases expression
ISO
Metformin results in increased expression of UCP2 mRNA; Metformin results in increased expression of UCP2 protein
CTD
PMID:22815988 PMID:34302933
NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
G
Ugt2a3
UDP glucuronosyltransferase family 2 member A3
increases expression
EXP
Metformin results in increased expression of UGT2A3 mRNA
CTD
PMID:31324951
NCBI chr14:20,572,793...20,590,795
Ensembl chr14:20,572,808...20,590,729
G
Ulk1
unc-51 like autophagy activating kinase 1
increases expression multiple interactions
ISO
Metformin results in increased expression of ULK1 mRNA [Metformin co-treated with Pioglitazone] results in increased expression of ULK1 mRNA
CTD
PMID:32589349
NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966
G
Ulk2
unc-51 like autophagy activating kinase 2
increases expression
ISO
Metformin results in increased expression of ULK2 mRNA
CTD
PMID:32589349
NCBI chr10:46,451,578...46,530,462
Ensembl chr10:46,454,030...46,530,407
G
Unkl
unk like zinc finger
decreases expression
EXP
Metformin results in decreased expression of UNKL mRNA
CTD
PMID:25596134
NCBI chr10:14,206,125...14,252,226
Ensembl chr10:14,206,189...14,252,225
G
Uqcrb
ubiquinol-cytochrome c reductase binding protein
multiple interactions
ISO
Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of UQCRB mRNA]
CTD
PMID:37337224
NCBI chr 7:63,814,784...63,820,150
Ensembl chr 7:63,814,797...63,820,150
G
Usp3
ubiquitin specific peptidase 3
increases expression
EXP
Metformin results in increased expression of USP3 mRNA
CTD
PMID:25596134
NCBI chr 8:67,078,249...67,154,109
Ensembl chr 8:67,079,927...67,154,111
G
Vars1
valyl-tRNA synthetase 1
increases expression
EXP
Metformin results in increased expression of VARS1 mRNA
CTD
PMID:25596134
NCBI chr20:3,805,774...3,820,468
Ensembl chr20:3,805,776...3,820,298
G
Vegfa
vascular endothelial growth factor A
decreases expression
ISO
Metformin results in decreased expression of VEGFA mRNA
CTD
PMID:23653852
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
G
Vegfb
vascular endothelial growth factor B
increases expression
EXP
Metformin results in increased expression of VEGFB mRNA
CTD
PMID:25596134
NCBI chr 1:204,172,297...204,178,046
Ensembl chr 1:204,172,225...204,177,944
G
Vgll4
vestigial-like family member 4
decreases expression
EXP
Metformin results in decreased expression of VGLL4 mRNA
CTD
PMID:31324951
NCBI chr 4:147,925,630...148,038,519
Ensembl chr 4:147,927,034...148,038,471
G
Vim
vimentin
decreases expression multiple interactions
ISO
Metformin results in decreased expression of VIM protein [Metformin co-treated with NVP-BKM120] results in decreased expression of VIM protein; Metformin inhibits the reaction [BMP2 protein results in increased expression of VIM mRNA]
CTD
PMID:35248696 PMID:37409753 PMID:38479708
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
G
Vnn1
vanin 1
multiple interactions
EXP
Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of VNN1 mRNA]
CTD
PMID:30551545
NCBI chr 1:21,537,084...21,547,395
Ensembl chr 1:21,537,094...21,547,395
G
Vps53
VPS53 subunit of GARP complex
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of VPS53 mRNA]
CTD
PMID:29095437
NCBI chr10:60,919,820...61,038,674
Ensembl chr10:60,919,820...61,038,676
G
Vsnl1
visinin-like 1
decreases expression
EXP
Metformin results in decreased expression of VSNL1 mRNA
CTD
PMID:31324951
NCBI chr 6:34,038,641...34,159,479
Ensembl chr 6:34,038,642...34,159,479
G
Wars1
tryptophanyl-tRNA synthetase 1
increases expression
EXP
Metformin results in increased expression of WARS1 mRNA
CTD
PMID:25596134
NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269
G
Wwc2
WW and C2 domain containing 2
increases expression
EXP
Metformin results in increased expression of WWC2 mRNA
CTD
PMID:25596134
NCBI chr16:44,258,372...44,421,815
Ensembl chr16:44,258,372...44,421,812
G
Xbp1
X-box binding protein 1
affects activity multiple interactions affects expression
EXP ISO
Metformin affects the activity of XBP1 protein Metformin inhibits the reaction [Glucose results in increased expression of XBP1 mRNA] Metformin inhibits the reaction [Rotenone results in increased expression of XBP1 mRNA] [Paclitaxel co-treated with Metformin] results in decreased expression of XBP1 mRNA; Metformin inhibits the reaction [INS protein results in increased expression of XBP1 protein] Metformin affects the expression of XBP1 mRNA
CTD
PMID:25596134 PMID:29309887 PMID:32189544 PMID:34801538 PMID:36764371
NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
G
Xpc
XPC complex subunit, DNA damage recognition and repair factor
decreases expression increases expression
EXP
Metformin results in decreased expression of XPC mRNA Metformin results in increased expression of XPC mRNA
CTD
PMID:25596134 PMID:31324951
NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010
G
Xrcc1
X-ray repair cross complementing 1
decreases activity multiple interactions
ISO
Metformin results in decreased activity of XRCC1 protein [Metformin co-treated with Hydrogen Peroxide] results in decreased activity of XRCC1 protein
CTD
PMID:29185360
NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701
G
Yars1
tyrosyl-tRNA synthetase 1
increases expression
EXP
Metformin results in increased expression of YARS1 mRNA
CTD
PMID:25596134
NCBI chr 5:141,535,815...141,564,029
Ensembl chr 5:141,535,759...141,563,833
G
Ypel2
yippee-like 2
decreases expression
EXP
Metformin results in decreased expression of YPEL2 mRNA
CTD
PMID:31324951
NCBI chr10:71,746,308...71,803,843
Ensembl chr10:71,746,311...71,803,911
G
Zbtb16
zinc finger and BTB domain containing 16
increases expression
EXP
Metformin results in increased expression of ZBTB16 mRNA
CTD
PMID:31324951
NCBI chr 8:48,989,376...49,177,011
Ensembl chr 8:48,994,566...49,177,011
G
Zbtb21
zinc finger and BTB domain containing 21
multiple interactions
ISO
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of ZBTB21 mRNA]
CTD
PMID:29095437
NCBI chr11:37,312,337...37,327,040
Ensembl chr11:37,312,378...37,326,996
G
Zfp239
zinc finger protein 239
increases expression
ISO
Metformin results in increased expression of ZFP239 mRNA
CTD
PMID:23457588
NCBI chr 4:151,029,431...151,039,283
Ensembl chr 4:151,029,405...151,039,529
G
Zfp354a
zinc finger protein 354A
increases expression
EXP
Metformin results in increased expression of ZFP354A mRNA
CTD
PMID:31324951
NCBI chr10:35,396,242...35,408,069
Ensembl chr10:35,396,231...35,408,068
G
Zfp36
zinc finger protein 36
decreases expression
EXP
Metformin results in decreased expression of ZFP36 mRNA
CTD
PMID:31324951
NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564
G
Zfp46
zinc finger protein 46
increases expression
EXP
Metformin results in increased expression of ZFP46 mRNA
CTD
PMID:31324951
NCBI chr 5:148,519,398...148,529,903
Ensembl chr 5:148,520,855...148,529,459
G
Zfp57
zinc finger protein 57
multiple interactions
ISO
Metformin inhibits the reaction [Dietary Fats results in increased expression of ZFP57 protein]
CTD
PMID:36375515
NCBI chr20:1,521,323...1,534,884
Ensembl chr20:1,521,323...1,529,846
G
Zfp791
zinc finger protein 791
decreases expression
ISO
Metformin results in decreased expression of ZFP791 mRNA
CTD
PMID:23457588
NCBI chr19:23,018,418...23,033,580
Ensembl chr19:23,018,918...23,033,504
G
A2m
alpha-2-macroglobulin
decreases expression
EXP
Phenformin results in decreased expression of A2M mRNA
CTD
PMID:31324951
NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
G
Abcb4
ATP binding cassette subfamily B member 4
increases expression
EXP
Phenformin results in increased expression of ABCB4 mRNA
CTD
PMID:31324951
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
G
Abcc3
ATP binding cassette subfamily C member 3
increases expression
EXP
Phenformin results in increased expression of ABCC3 mRNA
CTD
PMID:31324951
NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
G
Abcd2
ATP binding cassette subfamily D member 2
increases expression
EXP
Phenformin results in increased expression of ABCD2 mRNA
CTD
PMID:31324951
NCBI chr 7:122,263,034...122,311,642
Ensembl chr 7:122,263,032...122,311,642
G
Abcg2
ATP binding cassette subfamily G member 2
decreases expression
EXP
Phenformin results in decreased expression of ABCG2 mRNA
CTD
PMID:31324951
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
G
Abcg5
ATP binding cassette subfamily G member 5
increases expression
EXP
Phenformin results in increased expression of ABCG5 mRNA
CTD
PMID:31324951
NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
G
Abcg8
ATP binding cassette subfamily G member 8
increases expression
EXP
Phenformin results in increased expression of ABCG8 mRNA
CTD
PMID:31324951
NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912
G
Abra
actin-binding Rho activating protein
decreases expression
EXP
Phenformin results in decreased expression of ABRA mRNA
CTD
PMID:31324951
NCBI chr 7:72,970,187...72,974,255
Ensembl chr 7:72,970,186...72,974,255
G
Acaca
acetyl-CoA carboxylase alpha
decreases expression
EXP
Phenformin results in decreased expression of ACACA mRNA
CTD
PMID:31324951
NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
G
Ackr3
atypical chemokine receptor 3
decreases expression
EXP
Phenformin results in decreased expression of ACKR3 mRNA
CTD
PMID:31324951
NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237
G
Acly
ATP citrate lyase
decreases expression
EXP
Phenformin results in decreased expression of ACLY mRNA
CTD
PMID:31324951
NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
G
Acmsd
aminocarboxymuconate semialdehyde decarboxylase
increases expression
EXP
Phenformin results in increased expression of ACMSD mRNA
CTD
PMID:31324951
NCBI chr13:39,200,412...39,245,954
Ensembl chr13:39,200,314...39,245,209
G
Acsl3
acyl-CoA synthetase long-chain family member 3
decreases expression
EXP
Phenformin results in decreased expression of ACSL3 mRNA
CTD
PMID:31324951
NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627
G
Actg1
actin, gamma 1
decreases expression
EXP
Phenformin results in decreased expression of ACTG1 mRNA
CTD
PMID:31324951
NCBI chr10:105,619,738...105,622,587
Ensembl chr10:105,619,737...105,624,232 Ensembl chr 3:105,619,737...105,624,232
G
Adamts1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
decreases expression
EXP
Phenformin results in decreased expression of ADAMTS1 mRNA
CTD
PMID:31324951
NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103
G
Adh4
alcohol dehydrogenase 4 (class II), pi polypeptide
increases expression
EXP
Phenformin results in increased expression of ADH4 mRNA
CTD
PMID:31324951
NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591
G
Adh6
alcohol dehydrogenase 6 (class V)
increases expression
EXP
Phenformin results in increased expression of ADH6 mRNA
CTD
PMID:31324951
NCBI chr 2:226,903,208...226,934,564
Ensembl chr 2:226,903,250...226,934,534
G
Afmid
arylformamidase
decreases expression
EXP
Phenformin results in decreased expression of AFMID mRNA
CTD
PMID:31324951
NCBI chr10:103,046,129...103,061,718
Ensembl chr10:103,046,180...103,061,718
G
Agxt
alanine--glyoxylate aminotransferase
increases expression
EXP
Phenformin results in increased expression of AGXT mRNA
CTD
PMID:31324951
NCBI chr 9:93,675,384...93,685,337
Ensembl chr 9:93,675,384...93,685,336
G
Akr1b8-ps2
aldo-keto reductase family 1, member B8, pseudogene 2
decreases expression
EXP
Phenformin results in decreased expression of AKR1B8-PS2 mRNA
CTD
PMID:31324951
NCBI chr 6:77,569,720...77,571,967
G
Akt1
AKT serine/threonine kinase 1
increases phosphorylation
ISO
Phenformin results in increased phosphorylation of AKT1 protein
CTD
PMID:19901985
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
G
Alas2
5'-aminolevulinate synthase 2
decreases expression
EXP
Phenformin results in decreased expression of ALAS2 mRNA
CTD
PMID:31324951
NCBI chr X:19,463,146...19,486,526
Ensembl chr X:19,463,171...19,486,519
G
Aldh1a1
aldehyde dehydrogenase 1 family, member A1
increases expression
EXP
Phenformin results in increased expression of ALDH1A1 mRNA
CTD
PMID:31324951
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
G
Alox15
arachidonate 15-lipoxygenase
decreases expression
EXP
Phenformin results in decreased expression of ALOX15 mRNA
CTD
PMID:31324951
NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
G
Amacr
alpha-methylacyl-CoA racemase
increases expression
EXP
Phenformin results in increased expression of AMACR mRNA
CTD
PMID:31324951
NCBI chr 2:59,946,158...59,958,255
Ensembl chr 2:59,946,153...59,958,255
G
Amdhd1
amidohydrolase domain containing 1
increases expression
EXP
Phenformin results in increased expression of AMDHD1 mRNA
CTD
PMID:31324951
NCBI chr 7:28,043,923...28,059,156
Ensembl chr 7:28,043,716...28,059,156
G
Angptl4
angiopoietin-like 4
affects expression
EXP
Phenformin affects the expression of ANGPTL4 mRNA
CTD
PMID:31324951
NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
G
Angptl8
angiopoietin-like 8
decreases expression
EXP
Phenformin results in decreased expression of ANGPTL8 mRNA
CTD
PMID:31324951
NCBI chr 8:20,376,462...20,378,488
Ensembl chr 8:20,376,462...20,378,490
G
Ankh
ANKH inorganic pyrophosphate transport regulator
decreases expression
EXP
Phenformin results in decreased expression of ANKH mRNA
CTD
PMID:31324951
NCBI chr 2:78,153,027...78,280,181
Ensembl chr 2:78,153,026...78,280,187
G
Anlnl1
anillin, actin binding protein-like 1
decreases expression
EXP
Phenformin results in decreased expression of ANLNL1 mRNA
CTD
PMID:31324951
NCBI chr17:57,985,340...57,995,824
Ensembl chr17:57,986,511...57,989,997
G
Ano5
anoctamin 5
decreases expression
EXP
Phenformin results in decreased expression of ANO5 mRNA
CTD
PMID:31324951
NCBI chr 1:101,086,490...101,187,547
Ensembl chr 1:101,087,341...101,187,555
G
Apcdd1
APC down-regulated 1
increases expression
EXP
Phenformin results in increased expression of APCDD1 mRNA
CTD
PMID:31324951
NCBI chr18:56,385,398...56,416,065
Ensembl chr18:56,385,264...56,416,070
G
Aph1b
aph-1 homolog B, gamma secretase subunit
decreases expression
EXP
Phenformin results in decreased expression of APH1B mRNA
CTD
PMID:31324951
NCBI chr 8:67,429,198...67,454,735
Ensembl chr 8:67,429,198...67,450,243
G
Aplnr
apelin receptor
increases expression
EXP
Phenformin results in increased expression of APLNR mRNA
CTD
PMID:31324951
NCBI chr 3:70,217,407...70,221,052
Ensembl chr 3:70,217,385...70,221,050
G
Apoa4
apolipoprotein A4
decreases expression
EXP
Phenformin results in decreased expression of APOA4 mRNA
CTD
PMID:31324951
NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
G
Apoc4
apolipoprotein C4
increases expression
EXP
Phenformin results in increased expression of APOC4 mRNA
CTD
PMID:31324951
NCBI chr 1:79,335,745...79,339,942
Ensembl chr 1:79,335,745...79,339,981
G
Apof
apolipoprotein F
increases expression
EXP
Phenformin results in increased expression of APOF mRNA
CTD
PMID:31324951
NCBI chr 7:700,688...702,130
Ensembl chr 7:700,762...701,946
G
Apold1
apolipoprotein L domain containing 1
decreases expression
EXP
Phenformin results in decreased expression of APOLD1 mRNA
CTD
PMID:31324951
NCBI chr 4:167,768,437...167,825,706
Ensembl chr 4:167,818,271...167,825,706
G
Aqp7
aquaporin 7
increases expression
EXP
Phenformin results in increased expression of AQP7 mRNA
CTD
PMID:31324951
NCBI chr 5:56,171,649...56,186,642
Ensembl chr 5:56,172,519...56,186,642
G
Aqp9
aquaporin 9
increases expression
EXP
Phenformin results in increased expression of AQP9 mRNA
CTD
PMID:31324951
NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
G
Ar
androgen receptor
decreases expression
EXP
Phenformin results in decreased expression of AR mRNA
CTD
PMID:31324951
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
G
Arhgap11a
Rho GTPase activating protein 11A
decreases expression
EXP
Phenformin results in decreased expression of ARHGAP11A mRNA
CTD
PMID:31324951
NCBI chr 3:100,590,865...100,607,146
Ensembl chr 3:100,590,865...100,607,559
G
Arrdc4
arrestin domain containing 4
increases expression
EXP
Phenformin results in increased expression of ARRDC4 mRNA
CTD
PMID:31324951
NCBI chr 1:122,369,355...122,383,351
Ensembl chr 1:122,369,360...122,383,290
G
Asl
argininosuccinate lyase
increases expression
EXP
Phenformin results in increased expression of ASL mRNA
CTD
PMID:31324951
NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662
G
Aspm
assembly factor for spindle microtubules
decreases expression
EXP
Phenformin results in decreased expression of ASPM mRNA
CTD
PMID:31324951
NCBI chr13:51,074,849...51,123,755
Ensembl chr13:51,074,849...51,123,755
G
Aspn
asporin
decreases expression
EXP
Phenformin results in decreased expression of ASPN mRNA
CTD
PMID:31324951
NCBI chr17:15,079,910...15,104,369
Ensembl chr17:15,080,639...15,104,041
G
Atf3
activating transcription factor 3
decreases expression
EXP
Phenformin results in decreased expression of ATF3 mRNA
CTD
PMID:31324951
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
G
Aurkb
aurora kinase B
decreases expression
EXP
Phenformin results in decreased expression of AURKB mRNA
CTD
PMID:31324951
NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
G
Bex2
brain expressed X-linked 2
increases expression
EXP
Phenformin results in increased expression of BEX1 mRNA
CTD
PMID:31324951
NCBI chr X:99,019,847...99,021,375
Ensembl chr X:99,019,000...99,021,503
G
Bhlhe40
basic helix-loop-helix family, member e40
decreases expression
EXP
Phenformin results in decreased expression of BHLHE40 mRNA
CTD
PMID:31324951
NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774
G
Btg2
BTG anti-proliferation factor 2
decreases expression
EXP
Phenformin results in decreased expression of BTG2 mRNA
CTD
PMID:31324951
NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
G
Bub1
BUB1 mitotic checkpoint serine/threonine kinase
decreases expression
EXP
Phenformin results in decreased expression of BUB1 mRNA
CTD
PMID:31324951
NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650
G
C8h11orf54
similar to human chromosome 11 open reading frame 54
decreases expression
EXP
Phenformin results in decreased expression of C8H11ORF54 mRNA
CTD
PMID:31324951
NCBI chr 8:12,123,839...12,146,412
Ensembl chr 8:12,123,823...12,146,473
G
Car5a
carbonic anhydrase 5A
increases expression
EXP
Phenformin results in increased expression of CAR5A mRNA
CTD
PMID:31324951
NCBI chr19:49,973,092...50,002,948
Ensembl chr19:49,973,107...50,002,906
G
Car5b
carbonic anhydrase 5B
decreases expression
EXP
Phenformin results in decreased expression of CAR5B mRNA
CTD
PMID:31324951
NCBI chr X:30,474,697...30,534,797
Ensembl chr X:30,474,784...30,533,837
G
Ccdc141
coiled-coil domain containing 141
decreases expression
EXP
Phenformin results in decreased expression of CCDC141 mRNA
CTD
PMID:31324951
NCBI chr 3:61,948,614...62,109,968
Ensembl chr 3:61,948,646...62,110,079
G
Ccdc38
coiled-coil domain containing 38
increases expression
EXP
Phenformin results in increased expression of CCDC38 mRNA
CTD
PMID:31324951
NCBI chr 7:28,055,883...28,129,938
Ensembl chr 7:28,059,798...28,130,441
G
Ccdc77
coiled-coil domain containing 77
increases expression
EXP
Phenformin results in increased expression of CCDC77 mRNA
CTD
PMID:31324951
NCBI chr 4:153,534,184...153,566,059
Ensembl chr 4:153,534,187...153,566,545
G
Ccl2
C-C motif chemokine ligand 2
decreases expression
EXP
Phenformin results in decreased expression of CCL2 mRNA
CTD
PMID:31324951
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
G
Ccn2
cellular communication network factor 2
decreases expression
EXP
Phenformin results in decreased expression of CCN2 mRNA
CTD
PMID:31324951
NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
G
Ccna2
cyclin A2
decreases expression
EXP
Phenformin results in decreased expression of CCNA2 mRNA
CTD
PMID:31324951
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
G
Ccnb1
cyclin B1
decreases expression
EXP
Phenformin results in decreased expression of CCNB1 mRNA
CTD
PMID:31324951
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
G
Ccnb2
cyclin B2
affects expression
EXP
Phenformin affects the expression of CCNB2 mRNA
CTD
PMID:31324951
NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
G
Ccnd1
cyclin D1
increases expression
EXP
Phenformin results in increased expression of CCND1 mRNA
CTD
PMID:31324951
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
G
Ccne2
cyclin E2
decreases expression
EXP
Phenformin results in decreased expression of CCNE2 mRNA
CTD
PMID:31324951
NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
G
Cd226
CD226 molecule
decreases expression
EXP
Phenformin results in decreased expression of CD226 mRNA
CTD
PMID:31324951
NCBI chr18:82,449,924...82,545,107
Ensembl chr18:82,450,568...82,543,051
G
Cd274
CD274 molecule
increases expression
EXP
Phenformin results in increased expression of CD274 mRNA
CTD
PMID:31324951
NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450
G
Cd5l
Cd5 molecule-like
increases expression
EXP
Phenformin results in increased expression of CD5L mRNA
CTD
PMID:31324951
NCBI chr 2:172,791,007...172,802,018
Ensembl chr 2:172,790,934...172,829,753
G
Cd63
Cd63 molecule
increases expression
EXP
Phenformin results in increased expression of CD63 mRNA
CTD
PMID:31324951
NCBI chr 7:1,325,108...1,340,447
Ensembl chr 7:1,325,103...1,399,178
G
Cd74
CD74 molecule
increases expression
EXP
Phenformin results in increased expression of CD74 mRNA
CTD
PMID:31324951
NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003
G
Cdc20
cell division cycle 20
decreases expression
EXP
Phenformin results in decreased expression of CDC20 mRNA
CTD
PMID:31324951
NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
G
Cdk1
cyclin-dependent kinase 1
decreases expression
EXP
Phenformin results in decreased expression of CDK1 mRNA
CTD
PMID:31324951
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression decreases expression
ISO EXP
Phenformin results in increased expression of CDKN1A protein Phenformin results in decreased expression of CDKN1A mRNA
CTD
PMID:14623034 PMID:31324951
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
G
Cdkn3
cyclin-dependent kinase inhibitor 3
decreases expression
EXP
Phenformin results in decreased expression of CDKN3 mRNA
CTD
PMID:31324951
NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945
G
Cemip2
cell migration inducing hyaluronidase 2
decreases expression
EXP
Phenformin results in decreased expression of CEMIP2 mRNA
CTD
PMID:31324951
NCBI chr 1:219,330,295...219,407,760
Ensembl chr 1:219,337,985...219,407,760
G
Cenpe
centromere protein E
decreases expression
EXP
Phenformin results in decreased expression of CENPE mRNA
CTD
PMID:31324951
NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669
G
Cenpf
centromere protein F
decreases expression
EXP
Phenformin results in decreased expression of CENPF mRNA
CTD
PMID:31324951
NCBI chr13:101,184,127...101,229,714
Ensembl chr13:101,184,127...101,229,669
G
Ces2c
carboxylesterase 2C
increases expression
EXP
Phenformin results in increased expression of CES2C mRNA
CTD
PMID:31324951
NCBI chr 1:260,391,190...260,398,757
Ensembl chr 1:260,388,902...260,398,790
G
Ces4a
carboxylesterase 4A
decreases expression
EXP
Phenformin results in decreased expression of CES4A mRNA
CTD
PMID:31324951
NCBI chr19:33,011,731...33,030,119
Ensembl chr19:33,011,731...33,029,545
G
Chka
choline kinase alpha
decreases expression
EXP
Phenformin results in decreased expression of CHKA mRNA
CTD
PMID:31324951
NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516
G
Cish
cytokine inducible SH2-containing protein
decreases expression
EXP
Phenformin results in decreased expression of CISH mRNA
CTD
PMID:31324951
NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250
G
Ckap2
cytoskeleton associated protein 2
decreases expression
EXP
Phenformin results in decreased expression of CKAP2 mRNA
CTD
PMID:31324951
NCBI chr16:69,839,668...69,864,852
Ensembl chr16:69,839,630...69,864,913
G
Cks2
CDC28 protein kinase regulatory subunit 2
decreases expression
EXP
Phenformin results in decreased expression of CKS2 mRNA
CTD
PMID:31324951
NCBI chr17:13,570,611...13,575,770
G
Clec1a
C-type lectin domain family 1, member A
decreases expression
EXP
Phenformin results in decreased expression of CLEC1A mRNA
CTD
PMID:31324951
NCBI chr 4:162,875,360...162,902,571
Ensembl chr 4:162,877,346...162,901,247
G
Clec1b
C-type lectin domain family 1, member B
decreases expression
EXP
Phenformin results in decreased expression of CLEC1B mRNA
CTD
PMID:31324951
NCBI chr 4:162,847,978...162,856,291
Ensembl chr 4:162,848,010...162,856,291
G
Cpne8
copine 8
increases expression
EXP
Phenformin results in increased expression of CPNE8 mRNA
CTD
PMID:31324951
NCBI chr 7:121,615,293...121,789,507
Ensembl chr 7:121,615,294...121,790,377
G
Cpt1a
carnitine palmitoyltransferase 1A
increases expression
EXP
Phenformin results in increased expression of CPT1A mRNA
CTD
PMID:31324951
NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
G
Crat
carnitine O-acetyltransferase
increases expression
EXP
Phenformin results in increased expression of CRAT mRNA
CTD
PMID:31324951
NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255
G
Crot
carnitine O-octanoyltransferase
increases expression
EXP
Phenformin results in increased expression of CROT mRNA
CTD
PMID:31324951
NCBI chr 4:25,068,270...25,133,111
Ensembl chr 4:25,080,587...25,133,109
G
Cry1
cryptochrome circadian regulator 1
decreases expression
EXP
Phenformin results in decreased expression of CRY1 mRNA
CTD
PMID:31324951
NCBI chr 7:18,529,823...18,594,092
Ensembl chr 7:18,529,823...18,594,091
G
Cryl1
crystallin, lambda 1
increases expression
EXP
Phenformin results in increased expression of CRYL1 mRNA
CTD
PMID:31324951
NCBI chr15:31,427,011...31,545,997
Ensembl chr15:31,427,054...31,545,997
G
Csad
cysteine sulfinic acid decarboxylase
decreases expression
EXP
Phenformin results in decreased expression of CSAD mRNA
CTD
PMID:31324951
NCBI chr 7:133,308,571...133,337,914
Ensembl chr 7:133,308,574...133,337,615
G
Csrp1
cysteine and glycine-rich protein 1
decreases expression
EXP
Phenformin results in decreased expression of CSRP1 mRNA
CTD
PMID:31324951
NCBI chr13:47,158,171...47,179,388
Ensembl chr13:47,167,789...47,179,384
G
Cxcl1
C-X-C motif chemokine ligand 1
decreases expression
EXP
Phenformin results in decreased expression of CXCL1 mRNA
CTD
PMID:31324951
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
G
Cxcl10
C-X-C motif chemokine ligand 10
decreases expression
EXP
Phenformin results in decreased expression of CXCL10 mRNA
CTD
PMID:31324951
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
G
Cxcr4
C-X-C motif chemokine receptor 4
increases expression
EXP
Phenformin results in increased expression of CXCR4 mRNA
CTD
PMID:31324951
NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
G
Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
decreases expression
EXP
Phenformin results in decreased expression of CYP17A1 mRNA
CTD
PMID:31324951
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
G
Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
increases expression
EXP
Phenformin results in increased expression of CYP2B1 mRNA
CTD
PMID:31324951
NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
G
Cyp2c12
cytochrome P450, family 2, subfamily c, polypeptide 12
decreases expression
EXP
Phenformin results in decreased expression of CYP2C12 mRNA
CTD
PMID:31324951
NCBI chr 1:238,699,859...238,757,011
Ensembl chr 1:238,699,854...238,757,019
G
Cyp2c24
cytochrome P450, family 2, subfamily c, polypeptide 24
increases expression
EXP
Phenformin results in increased expression of CYP2C24 mRNA
CTD
PMID:31324951
NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
increases expression
EXP
Phenformin results in increased expression of CYP2E1 mRNA
CTD
PMID:31324951
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
G
Cyp3a18
cytochrome P450, family 3, subfamily a, polypeptide 18
increases expression
EXP
Phenformin results in increased expression of CYP3A18 mRNA
CTD
PMID:31324951
NCBI chr12:8,880,509...8,930,382
Ensembl chr12:8,880,528...8,930,381
G
Cyp4a1
cytochrome P450, family 4, subfamily a, polypeptide 1
increases expression
EXP
Phenformin results in increased expression of CYP4A1 mRNA
CTD
PMID:31324951
NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
G
Cyp4a2
cytochrome P450, family 4, subfamily a, polypeptide 2
increases expression
EXP
Phenformin results in increased expression of CYP4A2 mRNA
CTD
PMID:31324951
NCBI chr 5:128,922,355...128,934,188
Ensembl chr 5:128,923,615...128,934,165
G
Cyp7a1
cytochrome P450 family 7 subfamily A member 1
decreases expression
EXP
Phenformin results in decreased expression of CYP7A1 mRNA
CTD
PMID:31324951
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
G
Cyp8b1
cytochrome P450 family 8 subfamily B member 1
increases expression
EXP
Phenformin results in increased expression of CYP8B1 mRNA
CTD
PMID:31324951
NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
G
Dbp
D-box binding PAR bZIP transcription factor
increases expression
EXP
Phenformin results in increased expression of DBP mRNA
CTD
PMID:31324951
NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745
G
Dcn
decorin
decreases expression
EXP
Phenformin results in decreased expression of DCN mRNA
CTD
PMID:31324951
NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270
G
Ddhd1
DDHD domain containing 1
increases expression
EXP
Phenformin results in increased expression of DDHD1 mRNA
CTD
PMID:31324951
NCBI chr15:18,824,389...18,891,036
Ensembl chr15:18,824,394...18,890,952
G
Ddit4
DNA-damage-inducible transcript 4
decreases expression
EXP
Phenformin results in decreased expression of DDIT4 mRNA
CTD
PMID:31324951
NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
G
Decr1
2,4-dienoyl-CoA reductase 1
increases expression
EXP
Phenformin results in increased expression of DECR1 mRNA
CTD
PMID:31324951
NCBI chr 5:29,411,172...29,439,054
Ensembl chr 5:29,411,172...29,439,018
G
Depdc1
DEP domain containing 1
decreases expression
EXP
Phenformin results in decreased expression of DEPDC1 mRNA
CTD
PMID:31324951
NCBI chr 2:248,684,508...248,717,951
Ensembl chr 2:248,684,523...248,717,951
G
Diaph3
diaphanous-related formin 3
decreases expression
EXP
Phenformin results in decreased expression of DIAPH3 mRNA
CTD
PMID:31324951
NCBI chr15:62,543,375...63,013,060
Ensembl chr15:62,543,375...63,012,975
G
Dio1
iodothyronine deiodinase 1
decreases expression
EXP
Phenformin results in decreased expression of DIO1 mRNA
CTD
PMID:31324951
NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
G
Dmbt1
deleted in malignant brain tumors 1
increases expression
EXP
Phenformin results in increased expression of DMBT1 mRNA
CTD
PMID:31324951
NCBI chr 1:185,617,469...185,696,476
Ensembl chr 1:185,617,294...185,696,478
G
Dmxl2
Dmx-like 2
decreases expression
EXP
Phenformin results in decreased expression of DMXL2 mRNA
CTD
PMID:31324951
NCBI chr 8:54,741,164...54,884,948
Ensembl chr 8:54,741,160...54,885,161
G
Dusp1
dual specificity phosphatase 1
decreases expression
EXP
Phenformin results in decreased expression of DUSP1 mRNA
CTD
PMID:31324951
NCBI chr10:16,680,478...16,683,275
G
Ech1
enoyl-CoA hydratase 1
increases expression
EXP
Phenformin results in increased expression of ECH1 mRNA
CTD
PMID:31324951
NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
G
Eci1
enoyl-CoA delta isomerase 1
increases expression
EXP
Phenformin results in increased expression of ECI1 mRNA
CTD
PMID:31324951
NCBI chr10:13,456,715...13,470,061
Ensembl chr10:13,456,563...13,470,061
G
Ect2
epithelial cell transforming 2
decreases expression
EXP
Phenformin results in decreased expression of ECT2 mRNA
CTD
PMID:31324951
NCBI chr 2:109,975,813...110,037,911
Ensembl chr 2:109,975,813...110,037,911
G
Edem1
ER degradation enhancing alpha-mannosidase like protein 1
decreases expression
EXP
Phenformin results in decreased expression of EDEM1 mRNA
CTD
PMID:31324951
NCBI chr 4:141,797,631...141,829,717
Ensembl chr 4:141,797,701...141,829,717
G
Edil3
EGF like repeats and discoidin domains 3
decreases expression
EXP
Phenformin results in decreased expression of EDIL3 mRNA
CTD
PMID:31324951
NCBI chr 2:19,890,396...20,405,028
Ensembl chr 2:19,890,373...20,405,008
G
Egr1
early growth response 1
decreases expression
EXP
Phenformin results in decreased expression of EGR1 mRNA
CTD
PMID:31324951
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
G
Ell2
elongation factor for RNA polymerase II 2
decreases expression
EXP
Phenformin results in decreased expression of ELL2 mRNA
CTD
PMID:31324951
NCBI chr 2:5,189,375...5,258,781
Ensembl chr 2:5,189,971...5,258,781
G
Elovl2
ELOVL fatty acid elongase 2
increases expression
EXP
Phenformin results in increased expression of ELOVL2 mRNA
CTD
PMID:31324951
NCBI chr17:23,544,598...23,584,855
Ensembl chr17:23,544,568...23,584,848
G
Elovl6
ELOVL fatty acid elongase 6
decreases expression
EXP
Phenformin results in decreased expression of ELOVL6 mRNA
CTD
PMID:31324951
NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186
G
Erich5
glutamate-rich 5
decreases expression
EXP
Phenformin results in decreased expression of ERICH5 mRNA
CTD
PMID:31324951
NCBI chr 7:65,655,829...65,682,221
Ensembl chr 7:65,657,204...65,680,207
G
Errfi1
ERBB receptor feedback inhibitor 1
decreases expression
EXP
Phenformin results in decreased expression of ERRFI1 mRNA
CTD
PMID:31324951
NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282
G
Esco2
establishment of sister chromatid cohesion N-acetyltransferase 2
decreases expression
EXP
Phenformin results in decreased expression of ESCO2 mRNA
CTD
PMID:31324951
NCBI chr15:40,034,566...40,052,295
Ensembl chr15:40,034,568...40,055,306
G
Esm1
endothelial cell-specific molecule 1
increases expression
EXP
Phenformin results in increased expression of ESM1 mRNA
CTD
PMID:31324951
NCBI chr 2:44,876,067...44,884,805
Ensembl chr 2:44,876,067...44,884,804
G
F2rl2
coagulation factor II (thrombin) receptor-like 2
decreases expression
EXP
Phenformin results in decreased expression of F2RL2 mRNA
CTD
PMID:31324951
NCBI chr 2:26,972,054...26,977,098
Ensembl chr 2:26,972,054...26,977,098
G
F3
coagulation factor III, tissue factor
decreases expression
EXP
Phenformin results in decreased expression of F3 mRNA
CTD
PMID:31324951
NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
G
Fabp5
fatty acid binding protein 5
decreases expression
EXP
Phenformin results in decreased expression of FABP5 mRNA
CTD
PMID:31324951
NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773
G
Fam111a
FAM111 trypsin like peptidase A
decreases expression
EXP
Phenformin results in decreased expression of FAM111A mRNA
CTD
PMID:31324951
NCBI chr 1:209,640,865...209,656,551
Ensembl chr 1:209,640,953...209,656,547
G
Fam117b
family with sequence similarity 117, member B
increases expression
EXP
Phenformin results in increased expression of FAM117B mRNA
CTD
PMID:31324951
NCBI chr 9:61,340,284...61,418,531
Ensembl chr 9:61,340,249...61,408,483
G
Fam149a
family with sequence similarity 149, member A
decreases expression
EXP
Phenformin results in decreased expression of FAM149A mRNA
CTD
PMID:31324951
NCBI chr16:46,855,377...46,914,553
Ensembl chr16:46,854,635...46,912,066
G
Fam83d
family with sequence similarity 83, member D
decreases expression
EXP
Phenformin results in decreased expression of FAM83D mRNA
CTD
PMID:31324951
NCBI chr 3:147,421,941...147,441,211
Ensembl chr 3:147,421,908...147,441,192
G
Fasn
fatty acid synthase
decreases expression
EXP
Phenformin results in decreased expression of FASN mRNA
CTD
PMID:31324951
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
G
Fmo2
flavin containing dimethylaniline monoxygenase 2
decreases expression
EXP
Phenformin results in decreased expression of FMO2 mRNA
CTD
PMID:31324951
NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308
G
Fmo5
flavin containing dimethylaniline monoxygenase 5
increases expression
EXP
Phenformin results in increased expression of FMO5 mRNA
CTD
PMID:31324951
NCBI chr 2:185,197,184...185,249,699
Ensembl chr 2:185,222,204...185,249,693
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
decreases expression
EXP
Phenformin results in decreased expression of FOS mRNA
CTD
PMID:31324951
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
G
Foxa1
forkhead box A1
decreases expression
EXP
Phenformin results in decreased expression of FOXA1 mRNA
CTD
PMID:31324951
NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188
G
Foxa2
forkhead box A2
decreases expression
EXP
Phenformin results in decreased expression of FOXA2 mRNA
CTD
PMID:31324951
NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326
G
Foxo3
forkhead box O3
decreases expression
EXP
Phenformin results in decreased expression of FOXO3 mRNA
CTD
PMID:31324951
NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
G
Fpr1
formyl peptide receptor 1
decreases expression
EXP
Phenformin results in decreased expression of FPR1 mRNA
CTD
PMID:31324951
NCBI chr 1:58,745,019...58,756,776
Ensembl chr 1:58,747,246...58,756,559
G
Fras1
Fraser extracellular matrix complex subunit 1
decreases expression
EXP
Phenformin results in decreased expression of FRAS1 mRNA
CTD
PMID:31324951
NCBI chr14:12,791,407...13,200,862
Ensembl chr14:12,793,599...13,200,726
G
G6pc1
glucose-6-phosphatase catalytic subunit 1
decreases expression
EXP
Phenformin results in decreased expression of G6PC1 mRNA
CTD
PMID:31324951
NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
G
Gadd45g
growth arrest and DNA-damage-inducible, gamma
decreases expression
EXP
Phenformin results in decreased expression of GADD45G mRNA
CTD
PMID:31324951
NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610
G
Gbe1
1,4-alpha-glucan branching enzyme 1
decreases expression
EXP
Phenformin results in decreased expression of GBE1 mRNA
CTD
PMID:31324951
NCBI chr11:8,734,806...9,000,226
Ensembl chr11:8,734,820...9,000,210
G
Gbp1
guanylate binding protein 1
increases expression
EXP
Phenformin results in increased expression of GBP1 mRNA
CTD
PMID:31324951
NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131 Ensembl chr 2:231,398,163...231,432,131
G
Gbp1-ps1
guanylate binding protein 1, pseudogene 1
increases expression
EXP
Phenformin results in increased expression of GBP1-PS1 mRNA
CTD
PMID:31324951
NCBI chr 2:231,517,485...231,525,865
Ensembl chr 2:231,517,398...231,529,600
G
Gck
glucokinase
decreases expression
EXP
Phenformin results in decreased expression of GCK mRNA
CTD
PMID:31324951
NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
G
Gimd1
GIMAP family P-loop NTPase domain containing 1
decreases expression
EXP
Phenformin results in decreased expression of GIMD1 mRNA
CTD
PMID:31324951
NCBI chr 2:221,103,878...221,138,559
Ensembl chr 2:221,103,878...221,138,553
G
Gk
glycerol kinase
increases expression
EXP
Phenformin results in increased expression of GK mRNA
CTD
PMID:31324951
NCBI chr X:50,162,089...50,238,707
Ensembl chr X:50,163,123...50,238,631
G
Gnmt
glycine N-methyltransferase
increases expression
EXP
Phenformin results in increased expression of GNMT mRNA
CTD
PMID:31324951
NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434
G
Got1
glutamic-oxaloacetic transaminase 1
increases expression
EXP
Phenformin results in increased expression of GOT1 mRNA
CTD
PMID:31324951
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
G
Gp5
glycoprotein V (platelet)
decreases expression
EXP
Phenformin results in decreased expression of GP5 mRNA
CTD
PMID:31324951
NCBI chr11:70,443,613...70,446,705
Ensembl chr11:70,443,613...70,446,705
G
Gpa33
glycoprotein A33
increases expression
EXP
Phenformin results in increased expression of GPA33 mRNA
CTD
PMID:31324951
NCBI chr13:78,381,141...78,414,765
Ensembl chr13:78,381,141...78,414,765
G
Gpam
glycerol-3-phosphate acyltransferase, mitochondrial
increases expression
EXP
Phenformin results in increased expression of GPAM mRNA
CTD
PMID:31324951
NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
G
Gpat3
glycerol-3-phosphate acyltransferase 3
increases expression
EXP
Phenformin results in increased expression of GPAT3 mRNA
CTD
PMID:31324951
NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490
G
Gpd2
glycerol-3-phosphate dehydrogenase 2
increases expression
EXP
Phenformin results in increased expression of GPD2 mRNA
CTD
PMID:31324951
NCBI chr 3:41,800,552...41,937,729
Ensembl chr 3:41,801,930...41,936,901
G
Gpnmb
glycoprotein nmb
increases expression
EXP
Phenformin results in increased expression of GPNMB mRNA
CTD
PMID:31324951
NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367
G
Gprin3
GPRIN family member 3
decreases expression
EXP
Phenformin results in decreased expression of GPRIN3 mRNA
CTD
PMID:31324951
NCBI chr 4:88,572,062...88,657,369
Ensembl chr 4:88,563,607...88,657,429
G
Gpt
glutamic--pyruvic transaminase
increases expression
EXP
Phenformin results in increased expression of GPT mRNA
CTD
PMID:31324951
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
G
Gpx2-ps2
glutathione peroxidase 2, pseudogene 2
affects expression
EXP
Phenformin affects the expression of GPX2-PS2 mRNA
CTD
PMID:31324951
NCBI chr X:59,444,660...59,445,203
G
Gstm2
glutathione S-transferase mu 2
increases expression
EXP
Phenformin results in increased expression of GSTM2 mRNA
CTD
PMID:31324951
NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
G
Gstm4
glutathione S-transferase mu 4
increases expression
EXP
Phenformin results in increased expression of GSTM4 mRNA
CTD
PMID:31324951
NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323
G
Gstz1
glutathione S-transferase zeta 1
increases expression
EXP
Phenformin results in increased expression of GSTZ1 mRNA
CTD
PMID:31324951
NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284
G
Gypa
glycophorin A
decreases expression
EXP
Phenformin results in decreased expression of GYPA mRNA
CTD
PMID:31324951
NCBI chr19:27,450,304...27,465,940
Ensembl chr19:27,450,308...27,465,822
G
H2ac4
H2A clustered histone 4
decreases expression
EXP
Phenformin results in decreased expression of H2AC4 mRNA
CTD
PMID:31324951
NCBI chr17:42,799,884...42,800,387
Ensembl chr17:42,799,652...42,800,381
G
H2ax
H2A.X variant histone
decreases expression
EXP
Phenformin results in decreased expression of H2AX mRNA
CTD
PMID:31324951
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
G
Hamp
hepcidin antimicrobial peptide
decreases expression
EXP
Phenformin results in decreased expression of HAMP mRNA
CTD
PMID:31324951
NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
G
Hbb
hemoglobin subunit beta
decreases expression
EXP
Phenformin results in decreased expression of HBB-B1 mRNA
CTD
PMID:31324951
NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012
G
Hhex
hematopoietically expressed homeobox
decreases expression
EXP
Phenformin results in decreased expression of HHEX mRNA
CTD
PMID:31324951
NCBI chr 1:235,190,455...235,196,042
Ensembl chr 1:235,190,455...235,196,042
G
Hif1a
hypoxia inducible factor 1 subunit alpha
increases expression
ISO
Phenformin results in increased expression of HIF1A protein
CTD
PMID:26768367
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
G
Hist1h2af
histone cluster 1 H2A family member F
decreases expression
EXP
Phenformin results in decreased expression of HIST1H2AF mRNA
CTD
PMID:31324951
NCBI chr17:41,379,404...41,379,796
Ensembl chr17:41,379,404...41,379,796
G
Hist1h2ail1
histone cluster 1 H2a family member I like 1
decreases expression
EXP
Phenformin results in decreased expression of HIST1H2AIL1 mRNA
CTD
PMID:31324951
NCBI chr17:41,568,181...41,569,093
Ensembl chr17:41,568,471...41,569,109
G
Hist2h3c2
histone cluster 2 H3 family member C2
decreases expression
EXP
Phenformin results in decreased expression of HIST2H3C2 mRNA
CTD
PMID:31324951
NCBI chr 2:183,837,296...183,837,721
Ensembl chr 2:183,837,303...183,837,752
G
Hlf
HLF transcription factor, PAR bZIP family member
decreases expression
EXP
Phenformin results in decreased expression of HLF mRNA
CTD
PMID:31324951
NCBI chr10:75,154,244...75,211,884
Ensembl chr10:75,154,507...75,211,935
G
Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
decreases expression
EXP
Phenformin results in decreased expression of HMGCR mRNA
CTD
PMID:31324951
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
G
Hmmr
hyaluronan-mediated motility receptor
decreases expression
EXP
Phenformin results in decreased expression of HMMR mRNA
CTD
PMID:31324951
NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060
G
Hsd17b2
hydroxysteroid (17-beta) dehydrogenase 2
increases expression
EXP
Phenformin results in increased expression of HSD17B2 mRNA
CTD
PMID:31324951
NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202
G
Hsp90aa1
heat shock protein 90 alpha family class A member 1
decreases expression
EXP
Phenformin results in decreased expression of HSP90AA1 mRNA
CTD
PMID:31324951
NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
G
Hspa4l
heat shock protein family A (Hsp70) member 4 like
decreases expression
EXP
Phenformin results in decreased expression of HSPA4L mRNA
CTD
PMID:31324951
NCBI chr 2:123,740,384...123,793,088
Ensembl chr 2:123,740,384...123,793,084
G
Hykk
hydroxylysine kinase
increases expression
EXP
Phenformin results in increased expression of HYKK mRNA
CTD
PMID:31324951
NCBI chr 8:55,315,919...55,339,720
Ensembl chr 8:55,315,969...55,337,339
G
Ier2
immediate early response 2
decreases expression
EXP
Phenformin results in decreased expression of IER2 mRNA
CTD
PMID:31324951
NCBI chr19:23,494,551...23,496,075
Ensembl chr19:23,494,184...23,499,211
G
Ifgga4l
interferon-gamma-inducible GTPase 4 like
increases expression
EXP
Phenformin results in increased expression of IFGGA4L mRNA
CTD
PMID:31324951
NCBI chr18:53,838,426...53,854,858
Ensembl chr18:53,851,449...53,852,696
G
Ifitm3
interferon induced transmembrane protein 3
increases expression
EXP
Phenformin results in increased expression of IFITM3 mRNA
CTD
PMID:31324951
NCBI chr 1:196,111,026...196,112,135
Ensembl chr 1:196,111,043...196,112,203
G
Igf2bp3
insulin-like growth factor 2 mRNA binding protein 3
decreases expression
EXP
Phenformin results in decreased expression of IGF2BP3 mRNA
CTD
PMID:31324951
NCBI chr 4:78,060,494...78,195,007
Ensembl chr 4:78,060,494...78,194,865
G
Igfals
insulin-like growth factor binding protein, acid labile subunit
decreases expression
EXP
Phenformin results in decreased expression of IGFALS mRNA
CTD
PMID:31324951
NCBI chr10:13,897,468...13,903,920
Ensembl chr10:13,898,395...13,902,677
G
Igfbp2
insulin-like growth factor binding protein 2
increases expression
EXP
Phenformin results in increased expression of IGFBP2 mRNA
CTD
PMID:31324951
NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937
G
Igfbp5
insulin-like growth factor binding protein 5
decreases expression
EXP
Phenformin results in decreased expression of IGFBP5 mRNA
CTD
PMID:31324951
NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156
G
Il1r1
interleukin 1 receptor type 1
increases expression
EXP
Phenformin results in increased expression of IL1R1 mRNA
CTD
PMID:31324951
NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937
G
Il33
interleukin 33
increases expression
EXP
Phenformin results in increased expression of IL33 mRNA
CTD
PMID:31324951
NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
G
Inha
inhibin subunit alpha
decreases expression
EXP
Phenformin results in decreased expression of INHA mRNA
CTD
PMID:31324951
NCBI chr 9:76,994,465...76,997,366
Ensembl chr 9:76,993,589...76,997,248
G
Inhba
inhibin subunit beta A
decreases expression
EXP
Phenformin results in decreased expression of INHBA mRNA
CTD
PMID:31324951
NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
G
Inhbe
inhibin subunit beta E
increases expression
EXP
Phenformin results in increased expression of INHBE mRNA
CTD
PMID:31324951
NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172
G
Inmt
indolethylamine N-methyltransferase
increases expression
EXP
Phenformin results in increased expression of INMT mRNA
CTD
PMID:31324951
NCBI chr 4:84,318,197...84,322,493
Ensembl chr 4:84,318,197...84,322,493
G
Insig1
insulin induced gene 1
decreases expression
EXP
Phenformin results in decreased expression of INSIG1 mRNA
CTD
PMID:31324951
NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
G
Insig2
insulin induced gene 2
increases expression
EXP
Phenformin results in increased expression of INSIG2 mRNA
CTD
PMID:31324951
NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923
G
Ip6k2
inositol hexakisphosphate kinase 2
decreases expression
EXP
Phenformin results in decreased expression of IP6K2 mRNA
CTD
PMID:31324951
NCBI chr 8:109,483,843...109,510,172
Ensembl chr 8:109,484,310...109,510,166
G
Irf2bp2
interferon regulatory factor 2 binding protein 2
decreases expression
EXP
Phenformin results in decreased expression of IRF2BP2 mRNA
CTD
PMID:31324951
NCBI chr19:54,559,417...54,565,096
Ensembl chr19:54,560,128...54,566,642
G
Irf2bpl
interferon regulatory factor 2 binding protein-like
decreases expression
EXP
Phenformin results in decreased expression of IRF2BPL mRNA
CTD
PMID:31324951
NCBI chr 6:106,527,179...106,531,294
Ensembl chr 6:106,528,053...106,530,401
G
Irs2
insulin receptor substrate 2
decreases expression
EXP
Phenformin results in decreased expression of IRS2 mRNA
CTD
PMID:31324951
NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482
G
Jun
Jun proto-oncogene, AP-1 transcription factor subunit
decreases expression
EXP
Phenformin results in decreased expression of JUN mRNA
CTD
PMID:31324951
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
G
Junb
JunB proto-oncogene, AP-1 transcription factor subunit
decreases expression
EXP
Phenformin results in decreased expression of JUNB mRNA
CTD
PMID:31324951
NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
G
Kcna2
potassium voltage-gated channel subfamily A member 2
increases expression
EXP
Phenformin results in increased expression of KCNA2 mRNA
CTD
PMID:31324951
NCBI chr 2:194,704,555...194,718,387
Ensembl chr 2:194,704,639...194,718,400
G
Kcnj5
potassium inwardly-rectifying channel, subfamily J, member 5
increases expression
EXP
Phenformin results in increased expression of KCNJ5 mRNA
CTD
PMID:31324951
NCBI chr 8:30,724,923...30,753,083
Ensembl chr 8:30,724,925...30,753,518
G
Kif11
kinesin family member 11
decreases expression
EXP
Phenformin results in decreased expression of KIF11 mRNA
CTD
PMID:31324951
NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766
G
Kif20a
kinesin family member 20A
decreases expression
EXP
Phenformin results in decreased expression of KIF20A mRNA
CTD
PMID:31324951
NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780
G
Kif20b
kinesin family member 20B
decreases expression
EXP
Phenformin results in decreased expression of KIF20B mRNA
CTD
PMID:31324951
NCBI chr 1:232,428,293...232,483,798
Ensembl chr 1:232,428,371...232,483,787
G
Kif23
kinesin family member 23
decreases expression
EXP
Phenformin results in decreased expression of KIF23 mRNA
CTD
PMID:31324951
NCBI chr 8:62,397,908...62,425,162
Ensembl chr 8:62,397,948...62,425,072
G
Knl1
kinetochore scaffold 1
decreases expression
EXP
Phenformin results in decreased expression of KNL1 mRNA
CTD
PMID:31324951
NCBI chr 3:106,029,627...106,091,915
Ensembl chr 3:106,029,661...106,091,915
G
Krt18
keratin 18
increases expression
EXP
Phenformin results in increased expression of KRT18 mRNA
CTD
PMID:31324951
NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
G
Lbp
lipopolysaccharide binding protein
increases expression
EXP
Phenformin results in increased expression of LBP mRNA
CTD
PMID:31324951
NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586
G
Lepr
leptin receptor
increases response to substance
EXP
LEPR gene mutant form results in increased susceptibility to Phenformin
CTD
PMID:29743445
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
G
Lgals5
galectin 5
decreases expression
EXP
Phenformin results in decreased expression of LGALS5 mRNA
CTD
PMID:31324951
NCBI chr10:63,853,949...63,857,198
Ensembl chr10:63,853,935...63,857,153
G
Lgsn
lengsin, lens protein with glutamine synthetase domain
decreases expression
EXP
Phenformin results in decreased expression of LGSN mRNA
CTD
PMID:31324951
NCBI chr 9:33,416,362...33,447,919
Ensembl chr 9:33,420,484...33,447,907
G
Lipo1
lipase, member O1
decreases expression
EXP
Phenformin results in decreased expression of LIPO1 mRNA
CTD
PMID:31324951
NCBI chr 1:231,311,828...231,328,805
Ensembl chr 1:231,311,315...231,325,187
G
Loxl4
lysyl oxidase-like 4
increases expression
EXP
Phenformin results in increased expression of LOXL4 mRNA
CTD
PMID:31324951
NCBI chr 1:241,396,183...241,416,385
Ensembl chr 1:241,397,983...241,416,322
G
Lpar6
lysophosphatidic acid receptor 6
increases expression
EXP
Phenformin results in increased expression of LPAR6 mRNA
CTD
PMID:31324951
NCBI chr15:48,416,548...48,418,357
Ensembl chr15:48,416,544...48,422,331
G
Lpin1
lipin 1
decreases expression
EXP
Phenformin results in decreased expression of LPIN1 mRNA
CTD
PMID:31324951
NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097
G
Lum
lumican
decreases expression
EXP
Phenformin results in decreased expression of LUM mRNA
CTD
PMID:31324951
NCBI chr 7:32,358,990...32,365,794
Ensembl chr 7:32,358,614...32,365,793
G
Lurap1l
leucine rich adaptor protein 1-like
decreases expression
EXP
Phenformin results in decreased expression of LURAP1L mRNA
CTD
PMID:31324951
NCBI chr 5:95,362,005...95,409,439
Ensembl chr 5:95,362,005...95,409,438
G
Ly6c
Ly6-C antigen
increases expression
EXP
Phenformin results in increased expression of LY6C mRNA
CTD
PMID:31324951
NCBI chr 7:106,959,508...106,963,329
Ensembl chr 7:106,959,511...106,963,329
G
Lynx1
Ly6/neurotoxin 1
decreases expression
EXP
Phenformin results in decreased expression of LYNX1 mRNA
CTD
PMID:31324951
NCBI chr 7:106,632,800...106,638,003
Ensembl chr 7:106,632,797...106,638,023
G
Mastl
microtubule associated serine/threonine kinase-like
decreases expression
EXP
Phenformin results in decreased expression of MASTL mRNA
CTD
PMID:31324951
NCBI chr17:85,250,512...85,287,479
Ensembl chr17:85,251,997...85,287,353
G
Mbnl3
muscleblind-like splicing regulator 3
increases expression
EXP
Phenformin results in increased expression of MBNL3 mRNA
CTD
PMID:31324951
NCBI chr X:130,641,942...130,737,179
Ensembl chr X:130,648,538...130,737,056
G
Mest
mesoderm specific transcript
decreases expression
EXP
Phenformin results in decreased expression of MEST mRNA
CTD
PMID:31324951
NCBI chr 4:59,354,445...59,364,919
Ensembl chr 4:59,354,447...59,366,145
G
Mfap4
microfibril associated protein 4
decreases expression
EXP
Phenformin results in decreased expression of MFAP4 mRNA
CTD
PMID:31324951
NCBI chr10:46,167,158...46,170,176
Ensembl chr10:46,167,217...46,170,155
G
Mfsd2a
MFSD2 lysolipid transporter A, lysophospholipid
decreases expression
EXP
Phenformin results in decreased expression of MFSD2A mRNA
CTD
PMID:31324951
NCBI chr 5:135,225,801...135,240,744
Ensembl chr 5:135,225,816...135,240,690
G
Mgat4b
alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B
decreases expression
EXP
Phenformin results in decreased expression of MGAT4B mRNA
CTD
PMID:31324951
NCBI chr10:34,548,918...34,559,229
Ensembl chr10:34,549,433...34,559,229
G
Mgp
matrix Gla protein
decreases expression
EXP
Phenformin results in decreased expression of MGP mRNA
CTD
PMID:31324951
NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667
G
Mir15b
microRNA 15b
increases expression
EXP
Phenformin results in increased expression of MIR15B mRNA
CTD
PMID:31324951
NCBI chr 2:153,245,200...153,245,297
Ensembl chr 2:153,245,200...153,245,297
G
Mir29b2
microRNA 29b-2
increases expression
EXP
Phenformin results in increased expression of MIR29B2 mRNA
CTD
PMID:31324951
NCBI chr13:106,570,371...106,570,451
Ensembl chr13:106,570,367...106,570,456
G
Mirlet7c1
microRNA let-7c-1
increases expression
EXP
Phenformin results in increased expression of MIRLET7C-1 mRNA
CTD
PMID:31324951
NCBI chr11:16,201,163...16,201,256
Ensembl chr11:16,201,158...16,201,265
G
Mki67
marker of proliferation Ki-67
decreases expression
EXP
Phenformin results in decreased expression of MKI67 mRNA
CTD
PMID:31324951
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
G
Mknk2
MAPK interacting serine/threonine kinase 2
decreases expression
EXP
Phenformin results in decreased expression of MKNK2 mRNA
CTD
PMID:31324951
NCBI chr 7:9,039,771...9,050,832
Ensembl chr 7:9,039,728...9,050,827
G
Mlxipl
MLX interacting protein-like
decreases expression
EXP
Phenformin results in decreased expression of MLXIPL mRNA
CTD
PMID:31324951
NCBI chr12:21,541,608...21,577,120
Ensembl chr12:21,543,576...21,577,112
G
Mst1r
macrophage stimulating 1 receptor
decreases expression
EXP
Phenformin results in decreased expression of MST1R mRNA
CTD
PMID:31324951
NCBI chr 8:108,596,100...108,611,441
Ensembl chr 8:108,597,299...108,612,455
G
Mt1
metallothionein 1
increases expression
EXP
Phenformin results in increased expression of MT1A mRNA; Phenformin results in increased expression of MT1F mRNA; Phenformin results in increased expression of MT1M mRNA
CTD
PMID:31324951
NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049
G
Mt2A
metallothionein 2A
increases expression
EXP
Phenformin results in increased expression of MT2A mRNA
CTD
PMID:31324951
NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
G
Mtss1
MTSS I-BAR domain containing 1
decreases expression
EXP
Phenformin results in decreased expression of MTSS1 mRNA
CTD
PMID:31324951
NCBI chr 7:90,488,751...90,628,007
Ensembl chr 7:90,488,754...90,627,968
G
Mx2
MX dynamin like GTPase 2
increases expression
EXP
Phenformin results in increased expression of MX2 mRNA
CTD
PMID:31324951
NCBI chr11:36,905,698...36,936,308
Ensembl chr11:36,906,111...36,930,342
G
Myc
MYC proto-oncogene, bHLH transcription factor
decreases expression
EXP
Phenformin results in decreased expression of MYC mRNA
CTD
PMID:31324951
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
G
Myh7
myosin heavy chain 7
increases expression
EXP
Phenformin results in increased expression of MYH7 mRNA
CTD
PMID:31324951
NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
G
Myoc
myocilin
increases expression
EXP
Phenformin results in increased expression of MYOC mRNA
CTD
PMID:31324951
NCBI chr13:74,976,730...74,987,128
Ensembl chr13:74,976,730...74,987,127
G
Myom2
myomesin 2
increases expression
EXP
Phenformin results in increased expression of MYOM2 mRNA
CTD
PMID:31324951
NCBI chr16:74,520,148...74,592,658
Ensembl chr16:74,520,157...74,592,772
G
Ncapg
non-SMC condensin I complex, subunit G
decreases expression
EXP
Phenformin results in decreased expression of NCAPG mRNA
CTD
PMID:31324951
NCBI chr14:65,403,930...65,432,902
Ensembl chr14:65,404,163...65,432,902
G
Ncf1
neutrophil cytosolic factor 1
increases expression
EXP
Phenformin results in increased expression of NCF1 mRNA
CTD
PMID:31324951
NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
G
Ndc80
NDC80 kinetochore complex component
decreases expression
EXP
Phenformin results in decreased expression of NDC80 mRNA
CTD
PMID:31324951
NCBI chr 9:111,407,191...111,440,921
Ensembl chr 9:111,407,191...111,440,924
G
Nfe2l2
NFE2 like bZIP transcription factor 2
increases activity
ISO
Phenformin results in increased activity of NFE2L2 protein
CTD
PMID:30114225
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
G
Nfkbia
NFKB inhibitor alpha
decreases expression
EXP
Phenformin results in decreased expression of NFKBIA mRNA
CTD
PMID:31324951
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
G
Ngef
neuronal guanine nucleotide exchange factor
decreases expression
EXP
Phenformin results in decreased expression of NGEF mRNA
CTD
PMID:31324951
NCBI chr 9:88,146,956...88,244,454
Ensembl chr 9:88,146,956...88,244,914
G
Noct
nocturnin
decreases expression
EXP
Phenformin results in decreased expression of NOCT mRNA
CTD
PMID:31324951
NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:135,271,189...135,291,400
G
Nppa
natriuretic peptide A
increases expression
EXP
Phenformin results in increased expression of NPPA mRNA
CTD
PMID:31324951
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
G
Npr3
natriuretic peptide receptor 3
increases expression
EXP
Phenformin results in increased expression of NPR3 mRNA
CTD
PMID:31324951
NCBI chr 2:60,865,483...60,933,432
Ensembl chr 2:60,870,594...60,932,955
G
Npy
neuropeptide Y
affects expression
EXP
Phenformin affects the expression of NPY mRNA
CTD
PMID:31324951
NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
G
Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression
EXP
Phenformin results in increased expression of NQO1 mRNA
CTD
PMID:31324951
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
G
Nr1d1
nuclear receptor subfamily 1, group D, member 1
increases expression
EXP
Phenformin results in increased expression of NR1D1 mRNA
CTD
PMID:31324951
NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705
G
Nr1d2
nuclear receptor subfamily 1, group D, member 2
increases expression
EXP
Phenformin results in increased expression of NR1D2 mRNA
CTD
PMID:31324951
NCBI chr15:7,524,257...7,550,553
Ensembl chr15:7,524,257...7,550,553
G
Nr4a1
nuclear receptor subfamily 4, group A, member 1
decreases expression
EXP
Phenformin results in decreased expression of NR4A1 mRNA
CTD
PMID:31324951
NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
G
Nr4a2
nuclear receptor subfamily 4, group A, member 2
decreases expression
EXP
Phenformin results in decreased expression of NR4A2 mRNA
CTD
PMID:31324951
NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
G
Nr4a3
nuclear receptor subfamily 4, group A, member 3
decreases expression
EXP
Phenformin results in decreased expression of NR4A3 mRNA
CTD
PMID:31324951
NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733
G
Nuf2
NUF2 component of NDC80 kinetochore complex
decreases expression
EXP
Phenformin results in decreased expression of NUF2 mRNA
CTD
PMID:31324951
NCBI chr13:81,693,675...81,722,765
Ensembl chr13:81,693,598...81,722,766
G
Nusap1
nucleolar and spindle associated protein 1
decreases expression
EXP
Phenformin results in decreased expression of NUSAP1 mRNA
CTD
PMID:31324951
NCBI chr 3:106,603,273...106,633,428
Ensembl chr 3:106,603,289...106,633,624
G
Oaf
out at first homolog
increases expression
EXP
Phenformin results in increased expression of OAF mRNA
CTD
PMID:31324951
NCBI chr 8:43,594,362...43,612,334
Ensembl chr 8:43,594,363...43,612,334
G
Oat
ornithine aminotransferase
increases expression
EXP
Phenformin results in increased expression of OAT mRNA
CTD
PMID:31324951
NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682
G
Olr906
olfactory receptor 906
increases expression
EXP
Phenformin results in increased expression of OLR906 mRNA
CTD
PMID:31324951
NCBI chr 7:1,821,264...1,822,202
Ensembl chr 7:1,821,264...1,822,202
G
Omd
osteomodulin
decreases expression
EXP
Phenformin results in decreased expression of OMD mRNA
CTD
PMID:31324951
NCBI chr17:15,060,217...15,068,441
Ensembl chr17:15,060,217...15,068,441
G
Opcml
opioid binding protein/cell adhesion molecule-like
decreases expression
EXP
Phenformin results in decreased expression of OPCML mRNA
CTD
PMID:31324951
NCBI chr 8:26,788,988...27,304,551
Ensembl chr 8:26,192,841...27,300,620
G
Osbpl3
oxysterol binding protein-like 3
decreases expression
EXP
Phenformin results in decreased expression of OSBPL3 mRNA
CTD
PMID:31324951
NCBI chr 4:79,346,583...79,523,523
Ensembl chr 4:79,350,349...79,523,393
G
Osgin1
oxidative stress induced growth inhibitor 1
decreases expression
EXP
Phenformin results in decreased expression of OSGIN1 mRNA
CTD
PMID:31324951
NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516
G
Otud1
OTU deubiquitinase 1
decreases expression
EXP
Phenformin results in decreased expression of OTUD1 mRNA
CTD
PMID:31324951
NCBI chr17:82,259,920...82,262,770
Ensembl chr17:82,259,840...82,262,995
G
P2rx7
purinergic receptor P2X 7
increases expression
EXP
Phenformin results in increased expression of P2RX7 mRNA
CTD
PMID:31324951
NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619
G
P2ry2
purinergic receptor P2Y2
increases expression
EXP
Phenformin results in increased expression of P2RY2 mRNA
CTD
PMID:31324951
NCBI chr 1:155,352,050...155,367,423
Ensembl chr 1:155,351,165...155,367,632
G
Paqr9
progestin and adipoQ receptor family member 9
decreases expression
EXP
Phenformin results in decreased expression of PAQR9 mRNA
CTD
PMID:31324951
NCBI chr 8:96,114,249...96,116,546
G
Pbk
PDZ binding kinase
decreases expression
EXP
Phenformin results in decreased expression of PBK mRNA
CTD
PMID:31324951
NCBI chr15:40,022,873...40,034,014
Ensembl chr15:40,023,002...40,034,014
G
Pbld1
phenazine biosynthesis-like protein domain containing 1
increases expression
EXP
Phenformin results in increased expression of PBLD1 mRNA
CTD
PMID:31324951
NCBI chr20:25,551,274...25,566,543
Ensembl chr20:25,551,275...25,565,614
G
Pclaf
PCNA clamp associated factor
decreases expression
EXP
Phenformin results in decreased expression of PCLAF mRNA
CTD
PMID:31324951
NCBI chr 8:66,420,606...66,432,994
Ensembl chr 8:66,420,587...66,432,994 Ensembl chr 8:66,420,587...66,432,994
G
Pde4b
phosphodiesterase 4B
increases expression
EXP
Phenformin results in increased expression of PDE4B mRNA
CTD
PMID:31324951
NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696
G
Pdk4
pyruvate dehydrogenase kinase 4
increases expression
EXP
Phenformin results in increased expression of PDK4 mRNA
CTD
PMID:31324951
NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
G
Pdlim1
PDZ and LIM domain 1
decreases expression
EXP
Phenformin results in decreased expression of PDLIM1 mRNA
CTD
PMID:31324951
NCBI chr 1:239,042,372...239,091,074
Ensembl chr 1:239,042,385...239,091,076
G
Pdlim3
PDZ and LIM domain 3
decreases expression
EXP
Phenformin results in decreased expression of PDLIM3 mRNA
CTD
PMID:31324951
NCBI chr16:46,352,460...46,383,680
Ensembl chr16:46,352,467...46,383,657
G
Pdzrn3
PDZ domain containing RING finger 3
increases expression
EXP
Phenformin results in increased expression of PDZRN3 mRNA
CTD
PMID:31324951
NCBI chr 4:133,770,736...133,996,959
Ensembl chr 4:133,770,736...133,996,959
G
Penk
proenkephalin
increases expression
EXP
Phenformin results in increased expression of PENK mRNA
CTD
PMID:31324951
NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129
G
Per1
period circadian regulator 1
decreases expression
EXP
Phenformin results in decreased expression of PER1 mRNA
CTD
PMID:31324951
NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431
G
Per2
period circadian regulator 2
decreases expression
EXP
Phenformin results in decreased expression of PER2 mRNA
CTD
PMID:31324951
NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459
G
Pex11a
peroxisomal biogenesis factor 11 alpha
increases expression
EXP
Phenformin results in increased expression of PEX11A mRNA
CTD
PMID:31324951
NCBI chr 1:133,680,091...133,687,172
Ensembl chr 1:133,680,091...133,687,172
G
Pex16
peroxisomal biogenesis factor 16
increases expression
EXP
Phenformin results in increased expression of PEX16 mRNA
CTD
PMID:31324951
NCBI chr 3:78,347,212...78,352,603
Ensembl chr 3:78,343,164...78,353,207
G
Pf4
platelet factor 4
decreases expression
EXP
Phenformin results in decreased expression of PF4 mRNA
CTD
PMID:31324951
NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365
G
Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
decreases expression
EXP
Phenformin results in decreased expression of PFKFB1 mRNA
CTD
PMID:31324951
NCBI chr X:19,508,522...19,562,165
Ensembl chr X:19,508,546...19,562,182
G
Phtf1
putative homeodomain transcription factor 1
decreases expression
EXP
Phenformin results in decreased expression of PHTF1 mRNA
CTD
PMID:31324951
NCBI chr 2:191,470,849...191,537,399
Ensembl chr 2:191,473,130...191,512,078
G
Pi15
peptidase inhibitor 15
decreases expression
EXP
Phenformin results in decreased expression of PI15 mRNA
CTD
PMID:31324951
NCBI chr 5:1,395,094...1,423,213
Ensembl chr 5:1,395,094...1,423,213
G
Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
decreases expression
EXP
Phenformin results in decreased expression of PIK3R1 mRNA
CTD
PMID:31324951
NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
G
Pklr
pyruvate kinase L/R
decreases expression
EXP
Phenformin results in decreased expression of PKLR mRNA
CTD
PMID:31324951
NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
G
Pla2g12a
phospholipase A2, group XIIA
increases expression
EXP
Phenformin results in increased expression of PLA2G12A mRNA
CTD
PMID:31324951
NCBI chr 2:218,436,497...218,452,742
Ensembl chr 2:218,436,513...218,452,740
G
Plcg1
phospholipase C, gamma 1
increases phosphorylation
ISO
Phenformin results in increased phosphorylation of PLCG1 protein
CTD
PMID:19901985
NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330
G
Plin2
perilipin 2
decreases expression
EXP
Phenformin results in decreased expression of PLIN2 mRNA
CTD
PMID:31324951
NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319
G
Plk1
polo-like kinase 1
decreases expression
EXP
Phenformin results in decreased expression of PLK1 mRNA
CTD
PMID:31324951
NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400
G
Plppr1
phospholipid phosphatase related 1
decreases expression
EXP
Phenformin results in decreased expression of PLPPR1 mRNA
CTD
PMID:31324951
NCBI chr 5:63,437,457...63,725,286
Ensembl chr 5:63,437,816...63,763,835
G
Pnpla3
patatin-like phospholipase domain containing 3
decreases expression
EXP
Phenformin results in decreased expression of PNPLA3 mRNA
CTD
PMID:31324951
NCBI chr 7:115,293,538...115,314,077
Ensembl chr 7:115,293,538...115,314,077
G
Por
cytochrome p450 oxidoreductase
decreases expression
EXP
Phenformin results in decreased expression of POR mRNA
CTD
PMID:31324951
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
G
Potef
POTE ankyrin domain family, member F
decreases expression
EXP
Phenformin results in decreased expression of POTEF mRNA
CTD
PMID:31324951
NCBI chr18:23,626,518...23,629,132
Ensembl chr 3:72,977,767...72,979,694
G
Ppard
peroxisome proliferator-activated receptor delta
decreases expression
EXP
Phenformin results in decreased expression of PPARD mRNA
CTD
PMID:31324951
NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
G
Ppcs
phosphopantothenoylcysteine synthetase
increases expression
EXP
Phenformin results in increased expression of PPCS mRNA
CTD
PMID:31324951
NCBI chr 5:133,023,077...133,026,899
Ensembl chr 5:133,023,121...133,026,933
G
Ppm1k
protein phosphatase, Mg2+/Mn2+ dependent, 1K
increases expression
EXP
Phenformin results in increased expression of PPM1K mRNA
CTD
PMID:31324951
NCBI chr 4:87,612,198...87,638,993
Ensembl chr 4:87,612,204...87,636,152
G
Ppp1r15a
protein phosphatase 1, regulatory subunit 15A
decreases expression
EXP
Phenformin results in decreased expression of PPP1R15A mRNA
CTD
PMID:31324951
NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
G
Ppp1r3b
protein phosphatase 1, regulatory subunit 3B
decreases expression
EXP
Phenformin results in decreased expression of PPP1R3B mRNA
CTD
PMID:31324951
NCBI chr16:56,830,011...56,842,395
Ensembl chr16:56,829,660...56,842,406
G
Prc1
protein regulator of cytokinesis 1
decreases expression
EXP
Phenformin results in decreased expression of PRC1 mRNA
CTD
PMID:31324951
NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765
G
Prim1
DNA primase subunit 1
decreases expression
EXP
Phenformin results in decreased expression of PRIM1 mRNA
CTD
PMID:31324951
NCBI chr 7:446,342...462,526
Ensembl chr 7:431,805...462,526
G
Prkaa1
protein kinase AMP-activated catalytic subunit alpha 1
increases phosphorylation
ISO
Phenformin results in increased phosphorylation of PRKAA1 protein
CTD
PMID:19901985
NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
G
Prox1
prospero homeobox 1
increases expression
EXP
Phenformin results in increased expression of PROX1 mRNA
CTD
PMID:31324951
NCBI chr13:101,669,184...101,719,804
Ensembl chr13:101,669,184...101,711,183
G
Prrg4
proline rich and Gla domain 4
decreases expression
EXP
Phenformin results in decreased expression of PRRG4 mRNA
CTD
PMID:31324951
NCBI chr 3:91,214,646...91,243,347
Ensembl chr 3:91,214,653...91,243,273
G
Psmb8
proteasome 20S subunit beta 8
increases expression
EXP
Phenformin results in increased expression of PSMB8 mRNA
CTD
PMID:31324951
NCBI chr20:4,652,159...4,655,122
Ensembl chr20:4,652,159...4,655,283
G
Ptk6
protein tyrosine kinase 6
decreases expression
EXP
Phenformin results in decreased expression of PTK6 mRNA
CTD
PMID:31324951
NCBI chr 3:168,307,073...168,315,664
Ensembl chr 3:168,307,073...168,315,664
G
Ptpn3
protein tyrosine phosphatase, non-receptor type 3
increases expression
EXP
Phenformin results in increased expression of PTPN3 mRNA
CTD
PMID:31324951
NCBI chr 5:71,908,520...72,027,323
Ensembl chr 5:71,911,135...72,065,443
G
Pum3-ps3
pumilio RNA-binding family member 3, pseudogene 3
increases expression
EXP
Phenformin results in increased expression of PUM3-PS3 mRNA
CTD
PMID:31324951
NCBI chr12:16,357,131...16,359,221
G
Rab30
RAB30, member RAS oncogene family
increases expression
EXP
Phenformin results in increased expression of RAB30 mRNA
CTD
PMID:31324951
NCBI chr 1:146,803,719...146,898,369
Ensembl chr 1:146,803,714...146,892,181
G
Rapgef5
Rap guanine nucleotide exchange factor 5
decreases expression
EXP
Phenformin results in decreased expression of RAPGEF5 mRNA
CTD
PMID:31324951
NCBI chr 6:138,445,184...138,679,943
Ensembl chr 6:138,437,991...138,679,936
G
Rcan1
regulator of calcineurin 1
decreases expression
EXP
Phenformin results in decreased expression of RCAN1 mRNA
CTD
PMID:31324951
NCBI chr11:31,622,208...31,702,150
Ensembl chr11:31,622,210...31,702,045
G
Rdh5
retinol dehydrogenase 5
decreases expression
EXP
Phenformin results in decreased expression of RDH5 mRNA
CTD
PMID:31324951
NCBI chr 7:1,341,172...1,346,863
Ensembl chr 7:1,340,934...1,351,558
G
Reg3g
regenerating family member 3 gamma
increases expression
EXP
Phenformin results in increased expression of REG3G mRNA
CTD
PMID:31324951
NCBI chr 4:110,922,805...110,927,803
Ensembl chr 4:110,924,168...110,926,723
G
RGD1309362
similar to interferon-inducible GTPase
increases expression
EXP
Phenformin results in increased expression of RGD1309362 mRNA
CTD
PMID:31324951
G
Rgs2
regulator of G-protein signaling 2
decreases expression
EXP
Phenformin results in decreased expression of RGS2 mRNA
CTD
PMID:31324951
NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
G
Rp1
RP1, axonemal microtubule associated
decreases expression
EXP
Phenformin results in decreased expression of RP1 mRNA
CTD
PMID:31324951
NCBI chr 5:15,121,104...15,582,363
Ensembl chr 5:15,121,133...15,579,363
G
Rrm2
ribonucleotide reductase regulatory subunit M2
decreases expression
EXP
Phenformin results in decreased expression of RRM2 mRNA
CTD
PMID:31324951
NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773
G
RT1-A
RT1 class I, locus A
decreases expression
EXP
Phenformin results in decreased expression of RT1-A mRNA
CTD
PMID:31324951
G
Sbk1
SH3 domain binding kinase 1
increases expression
EXP
Phenformin results in increased expression of SBK1 mRNA
CTD
PMID:31324951
NCBI chr 1:180,807,092...180,851,910
Ensembl chr 1:180,807,099...180,851,885
G
Scarna15
small Cajal body-specific RNA 15
decreases expression
EXP
Phenformin results in decreased expression of SCARNA15 mRNA
CTD
PMID:31324951
NCBI chr 1:135,484,620...135,484,683
Ensembl chr 1:135,484,559...135,484,685 Ensembl chr 1:135,484,559...135,484,685
G
Scd
stearoyl-CoA desaturase
decreases expression
EXP
Phenformin results in decreased expression of SCD1 mRNA
CTD
PMID:31324951
NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
G
Sdc4
syndecan 4
decreases expression
EXP
Phenformin results in decreased expression of SDC4 mRNA
CTD
PMID:31324951
NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580
G
Sdr42e1
short chain dehydrogenase/reductase family 42E, member 1
increases expression
EXP
Phenformin results in increased expression of SDR42E1 mRNA
CTD
PMID:31324951
NCBI chr19:45,715,366...45,727,901
Ensembl chr19:45,715,399...45,727,901
G
Sds
serine dehydratase
increases expression
EXP
Phenformin results in increased expression of SDS mRNA
CTD
PMID:31324951
NCBI chr12:36,083,226...36,090,540
Ensembl chr12:36,083,229...36,088,203
G
Serpina7
serpin family A member 7
increases expression
EXP
Phenformin results in increased expression of SERPINA7 mRNA
CTD
PMID:31324951
NCBI chr X:102,663,242...102,722,319
Ensembl chr X:102,663,405...102,669,040
G
Serpinc1
serpin family C member 1
increases activity
ISO
Phenformin results in increased activity of SERPINC1 protein
CTD
PMID:29458015
NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293
G
Serpine1
serpin family E member 1
decreases expression
EXP
Phenformin results in decreased expression of SERPINE1 mRNA
CTD
PMID:31324951
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
G
Sik1
salt-inducible kinase 1
decreases expression
EXP
Phenformin results in decreased expression of SIK1 mRNA
CTD
PMID:31324951
NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991
G
Sirt1
sirtuin 1
decreases expression
ISO
Phenformin results in decreased expression of SIRT1 protein
CTD
PMID:26768367
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
G
Slc10a2
solute carrier family 10 member 2
decreases expression
EXP
Phenformin results in decreased expression of SLC10A2 mRNA
CTD
PMID:31324951
NCBI chr16:84,386,528...84,409,475
Ensembl chr16:84,374,862...84,409,475
G
Slc10a5
solute carrier family 10, member 5
decreases expression
EXP
Phenformin results in decreased expression of SLC10A5 mRNA
CTD
PMID:31324951
NCBI chr 2:91,457,540...91,458,844
Ensembl chr 2:91,444,454...91,489,651
G
Slc13a2
solute carrier family 13 member 2
decreases expression
EXP
Phenformin results in decreased expression of SLC13A2 mRNA
CTD
PMID:31324951
NCBI chr10:63,291,813...63,319,127
Ensembl chr10:63,291,815...63,319,127
G
Slc13a3
solute carrier family 13 member 3
increases expression
EXP
Phenformin results in increased expression of SLC13A3 mRNA
CTD
PMID:31324951
NCBI chr 3:154,141,878...154,204,604
Ensembl chr 3:154,141,872...154,204,606
G
Slc16a10
solute carrier family 16 member 10
increases expression
EXP
Phenformin results in increased expression of SLC16A10 mRNA
CTD
PMID:31324951
NCBI chr20:43,454,819...43,567,839
Ensembl chr20:43,459,709...43,567,839
G
Slc17a9
solute carrier family 17 member 9
decreases expression
EXP
Phenformin results in decreased expression of SLC17A9 mRNA
CTD
PMID:31324951
NCBI chr 3:167,839,246...167,857,462
Ensembl chr 3:167,839,385...167,855,985
G
Slc19a3
solute carrier family 19 member 3
multiple interactions
ISO
Phenformin inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Phenformin inhibits the reaction [SLC19A3 protein results in increased uptake of Thiamine]
CTD
PMID:26528626
NCBI chr 9:84,275,722...84,299,368
Ensembl chr 9:84,277,024...84,299,337
G
Slc1a2
solute carrier family 1 member 2
increases expression
EXP
Phenformin results in increased expression of SLC1A2 mRNA
CTD
PMID:31324951
NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498
G
Slc1a4
solute carrier family 1 member 4
increases expression
EXP
Phenformin results in increased expression of SLC1A4 mRNA
CTD
PMID:31324951
NCBI chr14:94,530,801...94,560,190
Ensembl chr14:94,529,084...94,560,418
G
Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Phenformin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
G
Slc22a23
solute carrier family 22, member 23
decreases expression
EXP
Phenformin results in decreased expression of SLC22A23 mRNA
CTD
PMID:31324951
NCBI chr17:30,544,106...30,709,790
Ensembl chr17:30,544,106...30,709,790
G
Slc22a4
solute carrier family 22 member 4
increases response to substance affects uptake
ISO
SLC22A4 protein results in increased susceptibility to Phenformin SLC22A4 protein affects the uptake of Phenformin
CTD
PMID:23221006
NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720
G
Slc22a5
solute carrier family 22 member 5
increases expression
EXP
Phenformin results in increased expression of SLC22A5 mRNA
CTD
PMID:31324951
NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
G
Slc25a23
solute carrier family 25 member 23
decreases expression
EXP
Phenformin results in decreased expression of SLC25A23 mRNA
CTD
PMID:31324951
NCBI chr 9:1,882,636...1,898,369
Ensembl chr 9:1,882,621...1,898,561
G
Slc25a47
solute carrier family 25, member 47
increases expression
EXP
Phenformin results in increased expression of SLC25A47 mRNA
CTD
PMID:31324951
NCBI chr 6:127,767,365...127,773,000
Ensembl chr 6:127,767,305...127,773,005
G
Slc27a1
solute carrier family 27 member 1
increases expression
EXP
Phenformin results in increased expression of SLC27A1 mRNA
CTD
PMID:31324951
NCBI chr16:18,278,984...18,300,173
Ensembl chr16:18,278,984...18,296,063
G
Slc2a12
solute carrier family 2 member 12
increases expression
EXP
Phenformin results in increased expression of SLC2A12 mRNA
CTD
PMID:31324951
NCBI chr 1:22,803,068...22,862,204
Ensembl chr 1:22,804,418...22,860,971
G
Slc2a5
solute carrier family 2 member 5
decreases expression
EXP
Phenformin results in decreased expression of SLC2A5 mRNA
CTD
PMID:31324951
NCBI chr 5:160,583,055...160,609,994
Ensembl chr 5:160,583,234...160,611,106
G
Slc34a2
solute carrier family 34 member 2
decreases expression
EXP
Phenformin results in decreased expression of SLC34A2 mRNA
CTD
PMID:31324951
NCBI chr14:57,910,931...57,930,236
Ensembl chr14:57,910,480...57,930,436
G
Slc35c2
solute carrier family 35 member C2
decreases expression
EXP
Phenformin results in decreased expression of SLC35C2 mRNA
CTD
PMID:31324951
NCBI chr 3:154,012,262...154,023,549
Ensembl chr 3:154,012,416...154,023,488
G
Slc38a2
solute carrier family 38, member 2
decreases expression
EXP
Phenformin results in decreased expression of SLC38A2 mRNA
CTD
PMID:31324951
NCBI chr 7:127,851,267...127,863,482
Ensembl chr 7:127,851,267...127,863,436
G
Slc47a1
solute carrier family 47 member 1
multiple interactions
ISO
Phenformin inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD
PMID:22419765
NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
G
Slc47a2
solute carrier family 47 member 2
multiple interactions
ISO
Phenformin inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD
PMID:22419765
NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
G
Slc4a1
solute carrier family 4 member 1 (Diego blood group)
decreases expression
EXP
Phenformin results in decreased expression of SLC4A1 mRNA
CTD
PMID:31324951
NCBI chr10:87,306,865...87,323,132
Ensembl chr10:87,306,872...87,323,117
G
Slc4a4
solute carrier family 4 member 4
increases expression
EXP
Phenformin results in increased expression of SLC4A4 mRNA
CTD
PMID:31324951
NCBI chr14:18,841,289...19,293,297
Ensembl chr14:18,845,159...19,272,883
G
Slc6a6
solute carrier family 6 member 6
increases expression
EXP
Phenformin results in increased expression of SLC6A6 mRNA
CTD
PMID:31324951
NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875
G
Smco1
single-pass membrane protein with coiled-coil domains 1
increases expression
EXP
Phenformin results in increased expression of SMCO1 mRNA
CTD
PMID:31324951
NCBI chr11:68,512,113...68,514,999
Ensembl chr11:68,509,150...68,515,003
G
Snai2
snail family transcriptional repressor 2
increases expression
EXP
Phenformin results in increased expression of SNAI2 mRNA
CTD
PMID:31324951
NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200
G
Sntb1
syntrophin, beta 1
increases expression
EXP
Phenformin results in increased expression of SNTB1 mRNA
CTD
PMID:31324951
NCBI chr 7:87,060,926...87,329,315
Ensembl chr 7:87,060,926...87,329,315
G
Socs2
suppressor of cytokine signaling 2
decreases expression
EXP
Phenformin results in decreased expression of SOCS2 mRNA
CTD
PMID:31324951
NCBI chr 7:30,006,360...30,045,161
Ensembl chr 7:30,008,578...30,043,548
G
Spink1
serine peptidase inhibitor, Kazal type 1
increases expression
EXP
Phenformin results in increased expression of SPINK1 mRNA
CTD
PMID:31324951
NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642
G
Srebf1
sterol regulatory element binding transcription factor 1
decreases expression
EXP
Phenformin results in decreased expression of SREBF1 mRNA
CTD
PMID:31324951
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
G
Stac3
SH3 and cysteine rich domain 3
decreases expression
EXP
Phenformin results in decreased expression of STAC3 mRNA
CTD
PMID:31324951
NCBI chr 7:63,343,078...63,350,590
Ensembl chr 7:63,343,186...63,350,589
G
Stat3
signal transducer and activator of transcription 3
increases expression
EXP
Phenformin results in increased expression of STAT3 mRNA
CTD
PMID:31324951
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
G
Stat5b
signal transducer and activator of transcription 5B
decreases activity
ISO
Phenformin results in decreased activity of STAT5B protein
CTD
PMID:30114225
NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
G
Stmn1
stathmin 1
decreases expression
EXP
Phenformin results in decreased expression of STMN1 mRNA
CTD
PMID:31324951
NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
G
Stxbp6
syntaxin binding protein 6
increases expression
EXP
Phenformin results in increased expression of STXBP6 mRNA
CTD
PMID:31324951
NCBI chr 6:61,920,756...62,157,405
Ensembl chr 6:61,920,756...62,158,024
G
Tbx3
T-box transcription factor 3
increases expression
EXP
Phenformin results in increased expression of TBX3 mRNA
CTD
PMID:31324951
NCBI chr12:36,879,924...36,894,849
Ensembl chr12:36,881,445...36,893,708
G
Tcap
titin-cap
increases expression
EXP
Phenformin results in increased expression of TCAP mRNA
CTD
PMID:31324951
NCBI chr10:83,381,719...83,382,887
Ensembl chr10:83,381,719...83,382,887
G
Tex36
testis expressed 36
increases expression
EXP
Phenformin results in increased expression of TEX36 mRNA
CTD
PMID:31324951
NCBI chr 1:188,390,062...188,404,448
Ensembl chr 1:188,390,064...188,404,377
G
Thbs1
thrombospondin 1
increases expression
EXP
Phenformin results in increased expression of THBS1 mRNA
CTD
PMID:31324951
NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440
G
Thrsp
thyroid hormone responsive
decreases expression
EXP
Phenformin results in decreased expression of THRSP mRNA
CTD
PMID:31324951
NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075
G
Tk1
thymidine kinase 1
decreases expression
EXP
Phenformin results in decreased expression of TK1 mRNA
CTD
PMID:31324951
NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920
G
Tkfc
triokinase and FMN cyclase
decreases expression
EXP
Phenformin results in decreased expression of TKFC mRNA
CTD
PMID:31324951
NCBI chr 1:207,238,230...207,253,035
Ensembl chr 1:207,236,557...207,252,737
G
Tm7sf2
transmembrane 7 superfamily member 2
increases expression
EXP
Phenformin results in increased expression of TM7SF2 mRNA
CTD
PMID:31324951
NCBI chr 1:203,355,930...203,360,287
Ensembl chr 1:203,355,931...203,360,270
G
Tmem30b
transmembrane protein 30B
increases expression
EXP
Phenformin results in increased expression of TMEM30B mRNA
CTD
PMID:31324951
NCBI chr 6:92,251,626...92,254,702
Ensembl chr 6:92,249,790...92,254,842
G
Tmem37
transmembrane protein 37
decreases expression
EXP
Phenformin results in decreased expression of TMEM37 mRNA
CTD
PMID:31324951
NCBI chr13:31,184,322...31,191,477
Ensembl chr13:31,171,355...31,191,077
G
Tmod4
tropomodulin 4
increases expression
EXP
Phenformin results in increased expression of TMOD4 mRNA
CTD
PMID:31324951
NCBI chr 2:182,695,709...182,700,540
Ensembl chr 2:182,695,709...182,700,540
G
Tnfaip2
TNF alpha induced protein 2
increases expression
EXP
Phenformin results in increased expression of TNFAIP2 mRNA
CTD
PMID:31324951
NCBI chr 6:130,476,832...130,489,914
Ensembl chr 6:130,476,889...130,489,914
G
Tnfaip3
TNF alpha induced protein 3
decreases expression
EXP
Phenformin results in decreased expression of TNFAIP3 mRNA
CTD
PMID:31324951
NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
G
Tnfsf13
TNF superfamily member 13
decreases expression
EXP
Phenformin results in decreased expression of TNFSF13 mRNA
CTD
PMID:31324951
NCBI chr10:54,400,054...54,403,723
Ensembl chr10:54,400,065...54,403,042
G
Tob2
transducer of ERBB2, 2
decreases expression
EXP
Phenformin results in decreased expression of TOB2 mRNA
CTD
PMID:31324951
NCBI chr 7:113,362,703...113,371,423
Ensembl chr 7:113,361,148...113,372,688
G
Top2a
DNA topoisomerase II alpha
decreases expression
EXP
Phenformin results in decreased expression of TOP2A mRNA
CTD
PMID:31324951
NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
G
Tp53inp1
tumor protein p53 inducible nuclear protein 1
decreases expression
EXP
Phenformin results in decreased expression of TP53INP1 mRNA
CTD
PMID:31324951
NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968
G
Tppp
tubulin polymerization promoting protein
decreases expression
EXP
Phenformin results in decreased expression of TPPP mRNA
CTD
PMID:31324951
NCBI chr 1:29,257,111...29,281,134
Ensembl chr 1:29,261,255...29,281,134
G
Tpx2
TPX2, microtubule nucleation factor
decreases expression
EXP
Phenformin results in decreased expression of TPX2 mRNA
CTD
PMID:31324951
NCBI chr 3:141,318,428...141,360,684
Ensembl chr 3:141,318,455...141,360,468
G
Trim24
tripartite motif-containing 24
increases expression
EXP
Phenformin results in increased expression of TRIM24 mRNA
CTD
PMID:31324951
NCBI chr 4:66,567,342...66,692,029
Ensembl chr 4:66,566,686...66,717,241
G
Trim50
tripartite motif-containing 50
increases expression
EXP
Phenformin results in increased expression of TRIM50 mRNA
CTD
PMID:31324951
NCBI chr12:21,300,784...21,317,668
Ensembl chr12:21,300,785...21,317,668
G
Tsc22d3
TSC22 domain family, member 3
decreases expression
EXP
Phenformin results in decreased expression of TSC22D3 mRNA
CTD
PMID:31324951
NCBI chr X:104,217,898...104,277,886
Ensembl chr X:104,217,925...104,276,861
G
Tsku
tsukushi, small leucine rich proteoglycan
decreases expression
EXP
Phenformin results in decreased expression of TSKU mRNA
CTD
PMID:31324951
NCBI chr 1:152,660,259...152,671,682
Ensembl chr 1:152,656,693...152,672,588
G
Tspan4
tetraspanin 4
decreases expression
EXP
Phenformin results in decreased expression of TSPAN4 mRNA
CTD
PMID:31324951
NCBI chr 1:196,571,307...196,593,842
Ensembl chr 1:196,572,228...196,617,448
G
Ttk
Ttk protein kinase
decreases expression
EXP
Phenformin results in decreased expression of TTK mRNA
CTD
PMID:31324951
NCBI chr 8:84,754,329...84,792,653
Ensembl chr 8:84,754,315...84,792,651
G
Tubb1
tubulin, beta 1 class VI
decreases expression
EXP
Phenformin results in decreased expression of TUBB1 mRNA
CTD
PMID:31324951
NCBI chr 3:163,247,990...163,257,460
Ensembl chr 3:163,247,967...163,256,063
G
Tubb2a
tubulin, beta 2A class IIa
decreases expression
EXP
Phenformin results in decreased expression of TUBB2A mRNA
CTD
PMID:31324951
NCBI chr17:30,796,842...30,800,713
Ensembl chr17:30,747,503...30,800,714
G
Txnip
thioredoxin interacting protein
increases expression
EXP
Phenformin results in increased expression of TXNIP mRNA
CTD
PMID:31324951
NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
G
Ube2c
ubiquitin-conjugating enzyme E2C
decreases expression
EXP
Phenformin results in decreased expression of UBE2C mRNA
CTD
PMID:31324951
NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339
G
Ucp3
uncoupling protein 3
increases expression
EXP
Phenformin results in increased expression of UCP3 mRNA
CTD
PMID:31324951
NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762
G
Ugdh
UDP-glucose 6-dehydrogenase
decreases expression
EXP
Phenformin results in decreased expression of UGDH protein
CTD
PMID:4270849
NCBI chr14:42,848,704...42,872,351
Ensembl chr14:42,848,854...42,872,354
G
Ugt2a3
UDP glucuronosyltransferase family 2 member A3
increases expression
EXP
Phenformin results in increased expression of UGT2A3 mRNA
CTD
PMID:31324951
NCBI chr14:20,572,793...20,590,795
Ensembl chr14:20,572,808...20,590,729
G
Ugt2b1
UDP glucuronosyltransferase 2 family, polypeptide B1
increases expression
EXP
Phenformin results in increased expression of UGT2B1 mRNA
CTD
PMID:31324951
NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
G
Ugt2b34l1
UDP glucuronosyltransferase 2 family, polypeptide B34 like 1
increases expression
EXP
Phenformin results in increased expression of UGT2B34L1 mRNA
CTD
PMID:31324951
NCBI chr14:21,146,140...21,167,706
Ensembl chr14:21,145,827...21,167,704
G
Upp2
uridine phosphorylase 2
increases expression
EXP
Phenformin results in increased expression of UPP2 mRNA
CTD
PMID:31324951
NCBI chr 3:43,273,048...43,317,417
Ensembl chr 3:43,273,048...43,317,417
G
Usp18
ubiquitin specific peptidase 18
increases expression
EXP
Phenformin results in increased expression of USP18 mRNA
CTD
PMID:31324951
NCBI chr 4:154,471,634...154,499,154
Ensembl chr 4:154,471,592...154,499,144
G
Usp2
ubiquitin specific peptidase 2
decreases expression
EXP
Phenformin results in decreased expression of USP2 mRNA
CTD
PMID:31324951
NCBI chr 8:44,411,457...44,439,668
Ensembl chr 8:44,411,607...44,438,331
G
Vgll4
vestigial-like family member 4
decreases expression
EXP
Phenformin results in decreased expression of VGLL4 mRNA
CTD
PMID:31324951
NCBI chr 4:147,925,630...148,038,519
Ensembl chr 4:147,927,034...148,038,471
G
Vnn1
vanin 1
increases expression
EXP
Phenformin results in increased expression of VNN1 mRNA
CTD
PMID:31324951
NCBI chr 1:21,537,084...21,547,395
Ensembl chr 1:21,537,094...21,547,395
G
Wee1
WEE1 G2 checkpoint kinase
decreases expression
EXP
Phenformin results in decreased expression of WEE1 mRNA
CTD
PMID:31324951
NCBI chr 1:164,173,681...164,197,688
Ensembl chr 1:164,174,779...164,197,688
G
Xiap
X-linked inhibitor of apoptosis
increases expression
EXP
Phenformin results in increased expression of XIAP mRNA
CTD
PMID:31324951
NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700
G
Ypel2
yippee-like 2
decreases expression
EXP
Phenformin results in decreased expression of YPEL2 mRNA
CTD
PMID:31324951
NCBI chr10:71,746,308...71,803,843
Ensembl chr10:71,746,311...71,803,911
G
Zbtb16
zinc finger and BTB domain containing 16
decreases expression
EXP
Phenformin results in decreased expression of ZBTB16 mRNA
CTD
PMID:31324951
NCBI chr 8:48,989,376...49,177,011
Ensembl chr 8:48,994,566...49,177,011
G
Zfp354a
zinc finger protein 354A
decreases expression
EXP
Phenformin results in decreased expression of ZFP354A mRNA
CTD
PMID:31324951
NCBI chr10:35,396,242...35,408,069
Ensembl chr10:35,396,231...35,408,068
G
Zfp36
zinc finger protein 36
decreases expression
EXP
Phenformin results in decreased expression of ZFP36 mRNA
CTD
PMID:31324951
NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564
G
Znf750
zinc finger protein 750
increases expression
EXP
Phenformin results in increased expression of ZNF750 mRNA
CTD
PMID:31324951
NCBI chr10:106,772,162...106,781,186
Ensembl chr10:106,772,669...106,781,200
G
Tacr1
tachykinin receptor 1
increases response to substance
EXP
TACR1 protein results in increased susceptibility to phenyl biguanide
CTD
PMID:16982039
NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all