Emb (embigin) - Rat Genome Database

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Gene: Emb (embigin) Rattus norvegicus
Analyze
Symbol: Emb
Name: embigin
RGD ID: 621067
Description: Predicted to enable cell-cell adhesion mediator activity. Involved in cell adhesion and plasma membrane lactate transport. Located in plasma membrane. Orthologous to human EMB (embigin); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: embigin homolog; embigin homolog (mouse)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8250,803,468 - 50,858,001 (+)NCBIGRCr8
mRatBN7.2249,070,509 - 49,125,042 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl249,069,087 - 49,125,050 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx256,185,272 - 56,239,842 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0254,243,931 - 54,298,501 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0249,129,728 - 49,184,290 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0249,682,763 - 49,733,475 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl249,682,754 - 49,732,253 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0268,054,533 - 68,107,895 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4249,098,743 - 49,155,221 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1249,026,975 - 49,083,453 (+)NCBI
Celera244,782,309 - 44,836,695 (+)NCBICelera
Cytogenetic Map2q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
all-trans-retinoic acid  (ISO)
Allylamine  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chlordecone  (ISO)
choline  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
curcumin  (ISO)
cylindrospermopsin  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (EXP)
disodium selenite  (ISO)
eugenol  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
hexachlorobenzene  (EXP)
indole-3-methanol  (EXP)
L-methionine  (ISO)
leflunomide  (ISO)
maneb  (ISO)
metformin  (EXP)
methylparaben  (ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
oxaliplatin  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
phenacetin  (EXP)
phenylhydrazine  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
rac-lactic acid  (ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sunitinib  (ISO)
testosterone  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tungsten  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
axon  (IBA)
membrane  (IEA)
plasma membrane  (IBA,IDA)
synapse  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Embigin, a developmentally expressed member of the immunoglobulin super family, is also expressed during regression of prostate and mammary gland. Guenette RS, etal., Dev Genet 1997;21(4):268-78.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein. Ovens MJ, etal., Biochem J. 2010 Oct 15;431(2):217-25. doi: 10.1042/BJ20100890.
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
9. Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70). Wilson MC, etal., J Biol Chem. 2005 Jul 22;280(29):27213-21. Epub 2005 May 24.
10. Studies on the DIDS-binding site of monocarboxylate transporter 1 suggest a homology model of the open conformation and a plausible translocation cycle. Wilson MC, etal., J Biol Chem. 2009 Jul 24;284(30):20011-21. doi: 10.1074/jbc.M109.014217. Epub 2009 May 27.
Additional References at PubMed
PMID:15489334   PMID:19164284   PMID:30446621  


Genomics

Comparative Map Data
Emb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8250,803,468 - 50,858,001 (+)NCBIGRCr8
mRatBN7.2249,070,509 - 49,125,042 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl249,069,087 - 49,125,050 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx256,185,272 - 56,239,842 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0254,243,931 - 54,298,501 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0249,129,728 - 49,184,290 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0249,682,763 - 49,733,475 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl249,682,754 - 49,732,253 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0268,054,533 - 68,107,895 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4249,098,743 - 49,155,221 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1249,026,975 - 49,083,453 (+)NCBI
Celera244,782,309 - 44,836,695 (+)NCBICelera
Cytogenetic Map2q14NCBI
EMB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38550,396,192 - 50,443,345 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl550,396,192 - 50,443,248 (-)EnsemblGRCh38hg38GRCh38
GRCh37549,692,026 - 49,737,122 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36549,730,230 - 49,772,958 (-)NCBINCBI36Build 36hg18NCBI36
Build 34549,730,233 - 49,772,958NCBI
Celera546,639,392 - 46,684,611 (-)NCBICelera
Cytogenetic Map5q11.1NCBI
HuRef546,656,951 - 46,701,888 (-)NCBIHuRef
CHM1_1549,694,085 - 49,739,302 (-)NCBICHM1_1
T2T-CHM13v2.0551,215,328 - 51,262,447 (-)NCBIT2T-CHM13v2.0
Emb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913117,357,109 - 117,410,951 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13117,345,072 - 117,410,951 (+)EnsemblGRCm39 Ensembl
GRCm3813117,220,573 - 117,274,415 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13117,208,536 - 117,274,415 (+)EnsemblGRCm38mm10GRCm38
MGSCv3713118,009,380 - 118,063,222 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613118,339,913 - 118,393,379 (+)NCBIMGSCv36mm8
Celera13121,622,857 - 121,676,167 (+)NCBICelera
Cytogenetic Map13D2.3NCBI
cM Map1365.4NCBI
Emb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544616,716,677 - 16,753,841 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544616,716,677 - 16,757,031 (+)NCBIChiLan1.0ChiLan1.0
EMB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2463,502,096 - 63,551,845 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1561,655,719 - 61,702,735 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0563,590,589 - 63,635,167 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1565,203,820 - 65,250,260 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl565,204,168 - 65,247,182 (+)Ensemblpanpan1.1panPan2
EMB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1464,409,497 - 64,460,215 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl464,409,589 - 64,459,376 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha464,169,708 - 64,219,478 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0464,907,837 - 64,957,630 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl464,907,865 - 64,956,791 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1464,672,241 - 64,720,515 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0464,795,117 - 64,843,296 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0465,328,657 - 65,378,436 (+)NCBIUU_Cfam_GSD_1.0
Emb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213207,717,925 - 207,770,608 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648016,654,092 - 16,704,186 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648016,654,388 - 16,705,112 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EMB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1630,120,493 - 30,287,793 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11630,121,072 - 30,170,495 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21631,718,891 - 31,763,638 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EMB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1446,678,490 - 46,730,944 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl446,681,540 - 46,730,472 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660824,484,344 - 4,536,366 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Emb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247599,085,231 - 9,157,643 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Emb
319 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:299
Count of miRNA genes:198
Interacting mature miRNAs:220
Transcripts:ENSRNOT00000015306
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)22997159351729300Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23502311780023117Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
12879863Bp402Blood pressure QTL 4020.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24112578956532139Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)24280460760653831Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24317101783575226Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 8 32 24 19 24 73 34 35 10
Low 1 35 25 17 17 8 10 1 1 6 1 8
Below cutoff 1

Sequence


RefSeq Acc Id: ENSRNOT00000079907   ⟹   ENSRNOP00000069012
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl249,070,496 - 49,120,929 (+)Ensembl
Rnor_6.0 Ensembl249,682,754 - 49,731,546 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000085576   ⟹   ENSRNOP00000069959
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl249,070,496 - 49,125,050 (+)Ensembl
Rnor_6.0 Ensembl249,682,853 - 49,732,253 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108249   ⟹   ENSRNOP00000078563
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl249,069,087 - 49,125,050 (+)Ensembl
RefSeq Acc Id: NM_053719   ⟹   NP_446171
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8250,803,468 - 50,858,001 (+)NCBI
mRatBN7.2249,070,509 - 49,125,042 (+)NCBI
Rnor_6.0249,682,763 - 49,733,475 (+)NCBI
Rnor_5.0268,054,533 - 68,107,895 (+)NCBI
RGSC_v3.4249,098,743 - 49,155,221 (+)RGD
Celera244,782,309 - 44,836,695 (+)RGD
Sequence:
RefSeq Acc Id: NP_446171   ⟸   NM_053719
- Peptide Label: precursor
- UniProtKB: O88775 (UniProtKB/Swiss-Prot),   A6I5U2 (UniProtKB/TrEMBL),   A0A0G2JWP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069959   ⟸   ENSRNOT00000085576
RefSeq Acc Id: ENSRNOP00000069012   ⟸   ENSRNOT00000079907
RefSeq Acc Id: ENSRNOP00000078563   ⟸   ENSRNOT00000108249
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88775-F1-model_v2 AlphaFold O88775 1-328 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691153
Promoter ID:EPDNEW_R1677
Type:initiation region
Name:Emb_1
Description:embigin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0249,682,750 - 49,682,810EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621067 AgrOrtholog
BioCyc Gene G2FUF-54306 BioCyc
Ensembl Genes ENSRNOG00000060329 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055006454 UniProtKB/Swiss-Prot
  ENSRNOG00060014030 UniProtKB/Swiss-Prot
  ENSRNOG00065020534 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000079907.2 UniProtKB/TrEMBL
  ENSRNOT00000085576 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000085576.2 UniProtKB/Swiss-Prot
  ENSRNOT00000108249.1 UniProtKB/TrEMBL
  ENSRNOT00055010509 UniProtKB/Swiss-Prot
  ENSRNOT00060024028 UniProtKB/Swiss-Prot
  ENSRNOT00065034774 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5621074 IMAGE-MGC_LOAD
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114511 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72351 IMAGE-MGC_LOAD
NCBI Gene 114511 ENTREZGENE
PANTHER PTHR10075 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10075:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Emb PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000060329 RatGTEx
  ENSRNOG00055006454 RatGTEx
  ENSRNOG00060014030 RatGTEx
  ENSRNOG00065020534 RatGTEx
SMART SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JU92_RAT UniProtKB/TrEMBL
  A0A0G2JWP4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G388_RAT UniProtKB/TrEMBL
  A6I5U2 ENTREZGENE, UniProtKB/TrEMBL
  EMB_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Emb  embigin  Emb  embigin homolog (mouse)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-12-15 Emb  embigin homolog (mouse)  Emb  embigin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Emb  embigin      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Emb  embigin      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process increased expression is correlated with the appearance of highly organized lumenal and ductal structures in the developing prostate gland 632509
gene_product member of the immunoglobulin superfamily (IgSF) class of cell adhesion molecules 632509