Gene: Tdo2 (tryptophan 2,3-dioxygenase) Rattus norvegicus
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Symbol: Tdo2
Name: tryptophan 2,3-dioxygenase
Description: ENCODES a protein that exhibits amino acid binding; heme binding; oxygen binding; INVOLVED IN response to nitroglycerin; tryptophan catabolic process to acetyl-CoA; tryptophan metabolic process; PARTICIPATES IN tryptophan metabolic pathway; kynurenine metabolic pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); autistic disorder (ortholog); Gilles de la Tourette syndrome (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-di-tert-butyl-4-methylphenol; 3H-1,2-dithiole-3-thione
AGR Description: Exhibits several functions, including amino acid binding activity, heme binding activity, and oxygen binding activity; involved in response to nitroglycerin and tryptophan catabolic process to acetyl-CoA; orthologous to human TDO2 (tryptophan 2,3-dioxygenase).
Merged Description: Exhibits several functions, including amino acid binding activity, heme binding activity, and oxygen binding activity; involved in response to nitroglycerin and tryptophan catabolic process to acetyl-CoA; orthologous to human TDO2 (tryptophan 2,3-dioxygenase); PARTICIPATES IN tryptophan metabolic pathway; kynurenine metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-di-tert-butyl-4-methylphenol; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Tdo; TO; TRPO; tryptamin 2,3-dioxygenase; tryptophan 2,3-dioxygenase A; tryptophan oxygenase; tryptophan pyrrolase; tryptophan-2,3-dioxygenase; tryptophan-23-dioxygenase; tryptophanase
Orthologs:
Homo sapiens (human) : TDO2 (tryptophan 2,3-dioxygenase)  HGNC  Alliance
Mus musculus (house mouse) : Tdo2 (tryptophan 2,3-dioxygenase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tdo2 (tryptophan 2,3-dioxygenase)
Pan paniscus (bonobo/pygmy chimpanzee) : TDO2 (tryptophan 2,3-dioxygenase)
Canis lupus familiaris (dog) : TDO2 (tryptophan 2,3-dioxygenase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tdo2 (tryptophan 2,3-dioxygenase)
Sus scrofa (pig) : TDO2 (tryptophan 2,3-dioxygenase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02180,897,059 - 180,914,919 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02200,305,349 - 200,323,296 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42173,594,020 - 173,611,833 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12173,544,125 - 173,561,939 (-)NCBI
Celera2161,299,362 - 161,317,278 (-)NCBICelera
Cytogenetic Map2q34NCBI
RH 3.4 Map21078.8RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


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References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
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Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Tdo2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68370
Created: 2001-07-11
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.