Tdo2 (tryptophan 2,3-dioxygenase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Tdo2 (tryptophan 2,3-dioxygenase) Rattus norvegicus
Analyze
Symbol: Tdo2
Name: tryptophan 2,3-dioxygenase
RGD ID: 68370
Description: Enables several functions, including heme binding activity; oxygen binding activity; and tryptophan 2,3-dioxygenase activity. Involved in response to nitroglycerin; tryptophan catabolic process to acetyl-CoA; and tryptophan metabolic process. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome and familial hypertryptophanemia. Orthologous to human TDO2 (tryptophan 2,3-dioxygenase); PARTICIPATES IN tryptophan metabolic pathway; kynurenine metabolic pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-di-tert-butyl-4-methylphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Tdo; TO; TRPO; tryptamin 2,3-dioxygenase; tryptophan 2,3-dioxygenase A; tryptophan oxygenase; tryptophan pyrrolase; tryptophan-2,3-dioxygenase; tryptophan-23-dioxygenase; tryptophanase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82169,567,656 - 169,585,586 (-)NCBIGRCr8
mRatBN7.22167,269,581 - 167,287,511 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2167,269,579 - 167,287,511 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2174,475,769 - 174,493,750 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02172,497,005 - 172,514,990 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02167,083,123 - 167,101,045 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02180,897,059 - 180,914,919 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2180,897,011 - 180,914,940 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02200,305,349 - 200,323,296 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42173,594,020 - 173,611,833 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12173,544,125 - 173,561,939 (-)NCBI
Celera2161,299,362 - 161,317,278 (-)NCBICelera
RH 3.4 Map21078.8RGD
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(5-hydroxyindol-3-yl)acetic acid  (ISO)
1-methyltryptophan  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP,ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
680C91  (ISO)
acetamide  (EXP)
actinomycin D  (EXP)
acyclovir  (EXP)
aflatoxin B1  (EXP,ISO)
allopurinol  (EXP)
amiodarone  (ISO)
ammonium chloride  (EXP)
andrographolide  (ISO)
anthranilic acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
bisphenol F  (ISO)
buspirone  (EXP)
buta-1,3-diene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
carbaryl  (EXP,ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
corticosterone  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
dexamethasone  (EXP,ISO)
dimethoate  (ISO)
dioxygen  (ISO)
dopamine  (EXP)
dorsomorphin  (ISO)
endosulfan  (EXP)
ethanol  (EXP)
fenofibrate  (ISO)
ferroheme b  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fumonisin B1  (ISO)
genistein  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
heme b  (EXP)
Heptachlor epoxide  (ISO)
hexachlorobenzene  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (EXP)
kynurenine  (ISO)
L-tryptophan  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
medroxyprogesterone acetate  (ISO)
melatonin  (EXP)
metformin  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
NADP zwitterion  (EXP)
NADP(+)  (EXP)
nickel atom  (ISO)
nitroglycerin  (EXP)
O-methyleugenol  (ISO)
ozone  (EXP)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (ISO)
pyridine  (EXP)
quercetin  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
serotonin  (EXP)
sevoflurane  (EXP)
sodium arsenite  (ISO)
succimer  (ISO)
sulfasalazine  (ISO)
sulindac  (EXP)
tauroursodeoxycholic acid  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
tolmetin  (EXP)
triclosan  (ISO)
valproic acid  (ISO)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Aryl hydrocarbon receptor control of a disease tolerance defence pathway. Bessede A, etal., Nature. 2014 Jul 10;511(7508):184-90. doi: 10.1038/nature13323.
2. Exon and intron variants in the human tryptophan 2,3-dioxygenase gene: potential association with Tourette syndrome, substance abuse and other disorders. Comings DE, etal., Pharmacogenetics 1996 Aug;6(4):307-18.
3. Comparative effects of oxygen on indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase of the kynurenine pathway. Dang Y, etal., Free Radic Biol Med. 2000 Feb 15;28(4):615-24.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
8. The kynurenine pathway and neurodegenerative disease. Maddison DC and Giorgini F, Semin Cell Dev Biol. 2015 Apr;40:134-41. doi: 10.1016/j.semcdb.2015.03.002. Epub 2015 Mar 12.
9. Deduced primary structure of rat tryptophan-2,3-dioxygenase. Maezono K, etal., Biochem Biophys Res Commun 1990 Jul 16;170(1):176-81.
10. The Effect of Systemic Nitroglycerin Administration on the Kynurenine Pathway in the Rat. Nagy-Grócz G, etal., Front Neurol. 2017 Jun 14;8:278. doi: 10.3389/fneur.2017.00278. eCollection 2017.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Enzymatic studies on tryptophan metabolism disorder in rats chronically exposed to carbon disulfide. Okayama A, etal., Toxicol Appl Pharmacol. 1988 Jul;94(3):356-61.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. The role of tryptophan 2,3-dioxygenase in the hormonal control of tryptophan metabolism in isolated rat liver cells. Effects of glucocorticoids and experimental diabetes. Salter M and Pogson CI, Biochem J. 1985 Jul 15;229(2):499-504.
18. The metabolism of L-tryptophan by isolated rat liver cells. Quantification of the relative importance of, and the effect of nutritional status on, the individual pathways of tryptophan metabolism. Smith SA, etal., Biochem J. 1980 Nov 15;192(2):673-86.
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
20. Cyclooxygenase inhibition targets neurons to prevent early behavioural decline in Alzheimer's disease model mice. Woodling NS, etal., Brain. 2016 Jul;139(Pt 7):2063-81. doi: 10.1093/brain/aww117. Epub 2016 May 13.
21. TDO as a therapeutic target in brain diseases. Yu CP, etal., Metab Brain Dis. 2016 Apr 13.
Additional References at PubMed
PMID:1511007   PMID:3582368   PMID:6327261   PMID:12477932   PMID:17223727   PMID:19632204   PMID:19835274   PMID:20737904   PMID:24472498   PMID:24722188   PMID:25416956   PMID:27762317  
PMID:28285122  


Genomics

Comparative Map Data
Tdo2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82169,567,656 - 169,585,586 (-)NCBIGRCr8
mRatBN7.22167,269,581 - 167,287,511 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2167,269,579 - 167,287,511 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2174,475,769 - 174,493,750 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02172,497,005 - 172,514,990 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02167,083,123 - 167,101,045 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02180,897,059 - 180,914,919 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2180,897,011 - 180,914,940 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02200,305,349 - 200,323,296 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42173,594,020 - 173,611,833 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12173,544,125 - 173,561,939 (-)NCBI
Celera2161,299,362 - 161,317,278 (-)NCBICelera
RH 3.4 Map21078.8RGD
Cytogenetic Map2q34NCBI
TDO2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384155,903,696 - 155,920,406 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4155,854,738 - 155,920,406 (+)EnsemblGRCh38hg38GRCh38
GRCh374156,824,848 - 156,841,558 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364157,044,297 - 157,061,000 (+)NCBINCBI36Build 36hg18NCBI36
Build 344157,182,451 - 157,199,155NCBI
Celera4154,156,425 - 154,173,133 (+)NCBICelera
Cytogenetic Map4q32.1NCBI
HuRef4152,563,673 - 152,580,472 (+)NCBIHuRef
CHM1_14156,802,468 - 156,819,210 (+)NCBICHM1_1
T2T-CHM13v2.04159,236,403 - 159,253,174 (+)NCBIT2T-CHM13v2.0
Tdo2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39381,865,719 - 81,883,035 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl381,864,397 - 81,883,509 (-)EnsemblGRCm39 Ensembl
GRCm38381,958,412 - 81,975,728 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl381,957,090 - 81,976,202 (-)EnsemblGRCm38mm10GRCm38
MGSCv37381,762,334 - 81,779,650 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36382,044,339 - 82,061,655 (-)NCBIMGSCv36mm8
Celera381,983,687 - 82,001,014 (-)NCBICelera
Cytogenetic Map3E3NCBI
cM Map335.97NCBI
Tdo2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547111,229,273 - 11,245,375 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547111,229,795 - 11,245,255 (-)NCBIChiLan1.0ChiLan1.0
TDO2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23153,815,073 - 153,831,699 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14154,170,941 - 154,187,261 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04148,269,097 - 148,285,533 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14160,085,840 - 160,102,266 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4160,085,645 - 160,102,266 (+)Ensemblpanpan1.1panPan2
TDO2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11553,406,110 - 53,424,260 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1553,405,957 - 53,423,958 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1553,741,684 - 53,760,577 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01554,113,213 - 54,132,114 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1554,113,237 - 54,131,283 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11553,366,630 - 53,385,412 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01553,475,754 - 53,494,647 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01553,790,005 - 53,808,893 (+)NCBIUU_Cfam_GSD_1.0
Tdo2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530136,991,004 - 37,015,635 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365762,537,702 - 2,555,785 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365762,537,702 - 2,555,790 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TDO2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl844,708,746 - 44,740,962 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1844,708,722 - 44,725,954 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2846,704,213 - 46,721,456 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TDO2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17102,467,075 - 102,485,434 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7102,467,640 - 102,485,394 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603782,125,379 - 82,143,064 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tdo2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248482,380,670 - 2,396,314 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248482,380,827 - 2,395,807 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tdo2
111 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:35
Interacting mature miRNAs:43
Transcripts:ENSRNOT00000015732
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2122609194206936711Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072175950118Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2152413072175950118Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072175950118Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072175950118Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072175950118Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2152413072175950118Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
631520Bp73Blood pressure QTL 730.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147686913168355276Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)228484589169504100Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)228484589169504100Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat

Markers in Region
D2Rat352  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22167,282,560 - 167,282,768 (+)MAPPERmRatBN7.2
Rnor_6.02180,909,971 - 180,910,178NCBIRnor6.0
Rnor_5.02200,318,348 - 200,318,555UniSTSRnor5.0
RGSC_v3.42173,606,885 - 173,607,092UniSTSRGSC3.4
RGSC_v3.42173,606,885 - 173,607,092RGDRGSC3.4
RGSC_v3.12173,556,991 - 173,557,198RGD
Celera2161,312,335 - 161,312,542UniSTS
FHH x ACI Map275.6799UniSTS
FHH x ACI Map275.6799RGD
Cytogenetic Map2q33UniSTS
RH127308  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22167,269,887 - 167,270,092 (+)MAPPERmRatBN7.2
Rnor_6.02180,897,366 - 180,897,570NCBIRnor6.0
Rnor_5.02200,305,656 - 200,305,860UniSTSRnor5.0
RGSC_v3.42173,594,327 - 173,594,531UniSTSRGSC3.4
Celera2161,299,669 - 161,299,873UniSTS
RH 3.4 Map21079.9UniSTS
Cytogenetic Map2q33UniSTS
RH142300  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22167,269,979 - 167,270,159 (+)MAPPERmRatBN7.2
Rnor_6.02180,897,458 - 180,897,637NCBIRnor6.0
Rnor_5.02200,305,748 - 200,305,927UniSTSRnor5.0
RGSC_v3.42173,594,419 - 173,594,598UniSTSRGSC3.4
Celera2161,299,761 - 161,299,940UniSTS
RH 3.4 Map21078.8UniSTS
Cytogenetic Map2q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 8 22 65 86 84 57 21 57 6 159 62 46 24 32 27

Sequence


Ensembl Acc Id: ENSRNOT00000015732   ⟹   ENSRNOP00000015732
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2167,269,579 - 167,287,511 (-)Ensembl
Rnor_6.0 Ensembl2180,897,011 - 180,914,940 (-)Ensembl
RefSeq Acc Id: NM_022403   ⟹   NP_071798
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82169,567,656 - 169,585,586 (-)NCBI
mRatBN7.22167,269,581 - 167,287,511 (-)NCBI
Rnor_6.02180,897,059 - 180,914,919 (-)NCBI
Rnor_5.02200,305,349 - 200,323,296 (-)NCBI
RGSC_v3.42173,594,020 - 173,611,833 (-)RGD
Celera2161,299,362 - 161,317,278 (-)RGD
Sequence:
RefSeq Acc Id: NP_071798   ⟸   NM_022403
- UniProtKB: Q5EBC2 (UniProtKB/Swiss-Prot),   Q6LBW3 (UniProtKB/Swiss-Prot),   P21643 (UniProtKB/Swiss-Prot),   A6J5T5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015732   ⟸   ENSRNOT00000015732

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21643-F1-model_v2 AlphaFold P21643 1-406 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691390
Promoter ID:EPDNEW_R1915
Type:single initiation site
Name:Tdo2_1
Description:tryptophan 2,3-dioxygenase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02180,914,938 - 180,914,998EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68370 AgrOrtholog
BioCyc Gene G2FUF-52692 BioCyc
BioCyc Pathway PWY-5651 [L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde] BioCyc
BioCyc Pathway Image PWY-5651 BioCyc
Ensembl Genes ENSRNOG00000011612 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055001502 UniProtKB/Swiss-Prot
  ENSRNOG00060007169 UniProtKB/Swiss-Prot
  ENSRNOG00065030816 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015732.4 UniProtKB/Swiss-Prot
  ENSRNOT00055002423 UniProtKB/Swiss-Prot
  ENSRNOT00060011803 UniProtKB/Swiss-Prot
  ENSRNOT00065053109 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.3810 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.58.480 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7370033 IMAGE-MGC_LOAD
InterPro Trp/Indoleamine_2_3_dOase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trp_2_3_dOase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64206 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108692 IMAGE-MGC_LOAD
NCBI Gene 64206 ENTREZGENE
PANTHER PTHR10138 UniProtKB/Swiss-Prot
  TRYPTOPHAN 2,3-DIOXYGENASE UniProtKB/Swiss-Prot
  TRYPTOPHAN 2,3-DIOXYGENASE UniProtKB/TrEMBL
  TRYPTOPHAN 2,3-DIOXYGENASE UniProtKB/TrEMBL
Pfam Trp_dioxygenase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tdo2 PhenoGen
RatGTEx ENSRNOG00000011612 RatGTEx
  ENSRNOG00055001502 RatGTEx
  ENSRNOG00060007169 RatGTEx
  ENSRNOG00065030816 RatGTEx
Superfamily-SCOP Indolic compounds 2,3-dioxygenase-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR TC222404
UniProt A6J5T5 ENTREZGENE, UniProtKB/TrEMBL
  A6J5T6_RAT UniProtKB/TrEMBL
  P21643 ENTREZGENE
  Q5EBC2 ENTREZGENE
  Q6LBW3 ENTREZGENE
  T23O_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q5EBC2 UniProtKB/Swiss-Prot
  Q6LBW3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Tdo2  tryptophan 2,3-dioxygenase      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein 406 amino acid residues with a molecular weight of 47,796 daltons 68206