Exhibits several functions, including heme binding activity; oxygen binding activity; and tryptophan 2,3-dioxygenase activity. Involved in response to nitroglycerin and tryptophan catabolic process to acetyl-CoA. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome. Orthologous to human TDO2 (tryptophan 2,3-dioxygenase); PARTICIPATES IN tryptophan metabolic pathway; kynurenine metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-di-tert-butyl-4-methylphenol; 3H-1,2-dithiole-3-thione.
[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TDO2 mRNA, Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to TDO2 gene]
Dexamethasone promotes the reaction [TDO2 enhancer binds to HNRNPU protein], Dexamethasone promotes the reaction [TDO2 promoter binds to HNRNPU protein]
Metformin inhibits the reaction [Dexamethasone results in increased expression of TDO2 mRNA], Metformin inhibits the reaction [Dexamethasone results in increased expression of TDO2 protein]
[Sulindac results in decreased activity of TDO2 protein] which results in decreased abundance of Dopamine, [Tolmetin results in decreased activity of TDO2 protein] which results in decreased abundance of Dopamine
[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TDO2 mRNA
Metformin inhibits the reaction [Dexamethasone results in increased expression of TDO2 mRNA], Metformin inhibits the reaction [Dexamethasone results in increased expression of TDO2 protein]
[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TDO2 mRNA
[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TDO2 mRNA
[Sulindac results in decreased activity of TDO2 protein] which results in increased abundance of Serotonin, [Tolmetin results in decreased activity of TDO2 protein] which results in increased abundance of Serotonin
[Sulindac results in decreased activity of TDO2 protein] which results in decreased abundance of Dopamine, [Sulindac results in decreased activity of TDO2 protein] which results in increased abundance of Serotonin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Gene-Chemical Interaction Annotations
