(-)-demecolcine increases expression ISO RGD:68531 6480464 Demecolcine results in increased expression of TDO2 mRNA CTD PMID:23649840 (5-hydroxyindol-3-yl)acetic acid increases abundance ISO RGD:68532 6480464 TDO2 gene mutant form results in increased abundance of Hydroxyindoleacetic Acid CTD PMID:32871117 1-methyltryptophan multiple interactions ISO RGD:68531 6480464 1-methyltryptophan inhibits the reaction [indeno(1 more ... CTD PMID:35687267 17alpha-ethynylestradiol multiple interactions ISO RGD:68532 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TDO2 mRNA CTD PMID:17942748 17beta-estradiol decreases expression ISO RGD:68531 6480464 Estradiol results in decreased expression of TDO2 mRNA CTD PMID:20106945 17beta-estradiol decreases expression EXP 6480464 Estradiol results in decreased expression of TDO2 mRNA CTD PMID:32145629 2,2',4,4'-Tetrabromodiphenyl ether increases expression ISO RGD:68531 6480464 2 more ... CTD PMID:23146750 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:68531 6480464 Tetrachlorodibenzodioxin results in decreased expression of TDO2 mRNA CTD PMID:20106945 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of TDO2 mRNA CTD PMID:34747641 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:68532 6480464 Tetrachlorodibenzodioxin results in decreased expression of TDO2 mRNA CTD PMID:28213091 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of TDO2 mRNA CTD PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:68532 6480464 Tetrachlorodibenzodioxin results in increased expression of TDO2 mRNA CTD PMID:19770486 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:68532 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TDO2 mRNA, Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to TDO2 gene] CTD PMID:17942748 , PMID:28213091 2,6-di-tert-butyl-4-methylphenol affects expression EXP 6480464 Butylated Hydroxytoluene affects the expression of TDO2 mRNA CTD PMID:18539377 2,6-di-tert-butyl-4-methylphenol increases expression ISO RGD:68532 6480464 Butylated Hydroxytoluene results in increased expression of TDO2 mRNA CTD PMID:19925653 3',5'-cyclic AMP multiple interactions ISO RGD:68531 6480464 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [[IFNG protein co-treated with [Medroxyprogesterone Acetate co-treated with Cyclic AMP]] results in increased expression of TDO2 mRNA], [IFNG protein co-treated with [Medroxyprogesterone Acetate co-treated with Cyclic AMP]] results in increased expression of TDO2 mRNA CTD PMID:32781018 3,3',4,4',5-pentachlorobiphenyl increases expression ISO RGD:68531 6480464 3 more ... CTD PMID:35618242 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1, 2-dithiol-3-thione results in decreased expression of TDO2 mRNA CTD PMID:19162173 4,4'-diaminodiphenylmethane decreases expression EXP 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of TDO2 mRNA CTD PMID:30723492 4,4'-sulfonyldiphenol decreases expression EXP 6480464 bis(4-hydroxyphenyl)sulfone results in decreased expression of TDO2 mRNA CTD PMID:26186136 4,4'-sulfonyldiphenol increases expression ISO RGD:68532 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of TDO2 mRNA CTD PMID:30951980 680C91 decreases activity ISO RGD:68532 6480464 TDO inhibitor LM10 results in decreased activity of TDO2 protein CTD PMID:21726069 acetamide decreases expression EXP 6480464 acetamide results in decreased expression of TDO2 mRNA CTD PMID:31881176 actinomycin D affects activity EXP 6480464 Dactinomycin affects the activity of TDO2 protein CTD PMID:7306070 acyclovir decreases activity EXP 6480464 Acyclovir results in decreased activity of TDO2 protein CTD PMID:18665439 aflatoxin B1 affects expression ISO RGD:68531 6480464 Aflatoxin B1 affects the expression of TDO2 protein CTD PMID:20106945 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of TDO2 mRNA CTD PMID:33354967 aflatoxin B1 decreases methylation ISO RGD:68531 6480464 Aflatoxin B1 results in decreased methylation of TDO2 gene CTD PMID:27153756 aflatoxin B1 decreases expression ISO RGD:68531 6480464 Aflatoxin B1 results in decreased expression of TDO2 mRNA CTD PMID:22100608 aflatoxin B1 decreases expression ISO RGD:68532 6480464 Aflatoxin B1 results in decreased expression of TDO2 mRNA CTD PMID:19770486 allopurinol affects activity EXP 6480464 Allopurinol affects the activity of TDO2 protein CTD PMID:7306070 amiodarone increases expression ISO RGD:68531 6480464 Amiodarone results in increased expression of TDO2 mRNA CTD PMID:19774075 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of TDO2 mRNA CTD PMID:16483693 andrographolide increases expression ISO RGD:68532 6480464 andrographolide results in increased expression of TDO2 mRNA CTD PMID:19737545 andrographolide multiple interactions ISO RGD:68532 6480464 [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of TDO2 mRNA CTD PMID:19737545 anthranilic acid decreases abundance ISO RGD:68532 6480464 TDO2 gene mutant form results in decreased abundance of anthranilic acid CTD PMID:32871117 atrazine affects methylation EXP 6480464 Atrazine affects the methylation of TDO2 gene CTD PMID:28931070 benzo[a]pyrene increases expression ISO RGD:68532 6480464 Benzo(a)pyrene results in increased expression of TDO2 mRNA CTD PMID:19770486 benzo[a]pyrene decreases expression ISO RGD:68531 6480464 Benzo(a)pyrene results in decreased expression of TDO2 mRNA CTD PMID:32234424 benzo[a]pyrene increases expression ISO RGD:68531 6480464 Benzo(a)pyrene results in increased expression of TDO2 mRNA CTD PMID:22316170 beta-naphthoflavone multiple interactions ISO RGD:68532 6480464 [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of TDO2 mRNA CTD PMID:19737545 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of TDO2 mRNA CTD PMID:26186136 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of TDO2 mRNA CTD PMID:30903817 , PMID:32145629 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of TDO2 mRNA CTD PMID:25181051 bisphenol F increases expression ISO RGD:68532 6480464 bisphenol F results in increased expression of TDO2 mRNA CTD PMID:30951980 buspirone increases expression EXP 6480464 Buspirone results in increased expression of TDO2 mRNA CTD PMID:24136188 buta-1,3-diene decreases expression ISO RGD:68532 6480464 1, 3-butadiene results in decreased expression of TDO2 mRNA CTD PMID:29038090 cadmium atom multiple interactions EXP 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased activity of TDO2 protein CTD PMID:35489423 cadmium dichloride multiple interactions EXP 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased activity of TDO2 protein CTD PMID:35489423 caffeine increases activity EXP 6480464 Caffeine results in increased activity of TDO2 protein CTD PMID:8164501 caffeine decreases phosphorylation ISO RGD:68531 6480464 Caffeine results in decreased phosphorylation of TDO2 protein CTD PMID:35688186 carbaryl decreases activity ISO RGD:68532 6480464 Carbaryl results in decreased activity of TDO2 protein CTD PMID:2547861 carbaryl decreases activity EXP 6480464 Carbaryl results in decreased activity of TDO2 protein CTD PMID:2119399 CGP 52608 multiple interactions ISO RGD:68531 6480464 CGP 52608 promotes the reaction [RORA protein binds to TDO2 gene] CTD PMID:28238834 chloroprene increases expression ISO RGD:68532 6480464 Chloroprene results in increased expression of TDO2 mRNA CTD PMID:23125180 chlorpyrifos increases methylation EXP 6480464 Chlorpyrifos results in increased methylation of TDO2 gene CTD PMID:32905263 ciguatoxin CTX1B affects expression ISO RGD:68532 6480464 Ciguatoxins affects the expression of TDO2 mRNA CTD PMID:18353800 cisplatin increases expression ISO RGD:68532 6480464 Cisplatin results in increased expression of TDO2 mRNA CTD PMID:15464296 , PMID:15471895 clofibrate increases expression ISO RGD:68532 6480464 Clofibrate results in increased expression of TDO2 mRNA CTD PMID:17585979 corticosterone increases activity EXP 6480464 Corticosterone results in increased activity of TDO2 protein CTD PMID:7306070 cyclophosphamide multiple interactions EXP 6480464 Quercetin inhibits the reaction [Cyclophosphamide results in increased activity of TDO2 protein] CTD PMID:35906875 cyclophosphamide increases activity EXP 6480464 Cyclophosphamide results in increased activity of TDO2 protein CTD PMID:35906875 cyclosporin A decreases expression ISO RGD:68531 6480464 Cyclosporine results in decreased expression of TDO2 mRNA CTD PMID:20106945 more ... cyclosporin A decreases expression ISO RGD:68532 6480464 Cyclosporine results in decreased expression of TDO2 mRNA CTD PMID:23830897 cylindrospermopsin increases expression ISO RGD:68531 6480464 cylindrospermopsin results in increased expression of TDO2 mRNA CTD PMID:24921660 dexamethasone increases expression ISO RGD:68531 6480464 Dexamethasone results in increased expression of TDO2 mRNA, Dexamethasone results in increased expression of TDO2 protein CTD PMID:25110054 dexamethasone multiple interactions EXP 6480464 Dexamethasone promotes the reaction [TDO2 enhancer binds to HNRNPU protein], Dexamethasone promotes the reaction [TDO2 promoter binds to HNRNPU protein] CTD PMID:19632204 dexamethasone multiple interactions ISO RGD:68531 6480464 Metformin inhibits the reaction [Dexamethasone results in increased expression of TDO2 mRNA], Metformin inhibits the reaction [Dexamethasone results in increased expression of TDO2 protein] CTD PMID:25110054 dimethoate decreases activity ISO RGD:68532 6480464 Dimethoate results in decreased activity of TDO2 protein CTD PMID:2547861 dioxygen decreases expression ISO RGD:68531 6480464 Oxygen deficiency results in decreased expression of TDO2 mRNA CTD PMID:19695866 dopamine multiple interactions EXP 6480464 [Sulindac results in decreased activity of TDO2 protein] which results in decreased abundance of Dopamine, [Tolmetin results in decreased activity of TDO2 protein] which results in decreased abundance of Dopamine CTD PMID:16952380 dorsomorphin multiple interactions ISO RGD:68531 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TDO2 mRNA CTD PMID:27188386 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of TDO2 mRNA CTD PMID:29391264 ethanol decreases expression EXP 6480464 Ethanol results in decreased expression of TDO2 mRNA CTD PMID:17920746 fenofibrate increases expression ISO RGD:68531 6480464 Fenofibrate results in increased expression of TDO2 mRNA CTD PMID:25572481 ferroheme b multiple interactions EXP 6480464 Heme promotes the reaction [pyridine results in increased activity of TDO2 protein] CTD PMID:10413312 flutamide decreases expression EXP 6480464 Flutamide results in decreased expression of TDO2 mRNA CTD PMID:24793618 folic acid increases expression ISO RGD:68532 6480464 Folic Acid results in increased expression of TDO2 mRNA CTD PMID:25006883 fumonisin B1 decreases expression ISO RGD:68532 6480464 fumonisin B1 results in decreased expression of TDO2 mRNA CTD PMID:16221962 genistein decreases expression ISO RGD:68532 6480464 Genistein results in decreased expression of TDO2 mRNA CTD PMID:32186404 glyphosate increases expression ISO RGD:68532 6480464 glyphosate results in increased expression of TDO2 protein CTD PMID:37208198 gold atom decreases expression ISO RGD:68531 6480464 Gold results in decreased expression of TDO2 mRNA CTD PMID:25523186 gold(0) decreases expression ISO RGD:68531 6480464 Gold results in decreased expression of TDO2 mRNA CTD PMID:25523186 heme b multiple interactions EXP 6480464 Heme promotes the reaction [pyridine results in increased activity of TDO2 protein] CTD PMID:10413312 Heptachlor epoxide decreases expression ISO RGD:68532 6480464 Heptachlor Epoxide results in decreased expression of TDO2 mRNA CTD PMID:25270620 Indeno[1,2,3-cd]pyrene multiple interactions ISO RGD:68531 6480464 1-methyltryptophan inhibits the reaction [indeno(1 more ... CTD PMID:35687267 Indeno[1,2,3-cd]pyrene increases expression ISO RGD:68531 6480464 indeno(1 more ... CTD PMID:35687267 indometacin increases expression EXP 6480464 Indomethacin results in increased expression of TDO2 mRNA CTD PMID:36868495 kynurenine decreases abundance ISO RGD:68532 6480464 TDO2 gene mutant form results in decreased abundance of Kynurenine CTD PMID:32871117 L-tryptophan increases abundance ISO RGD:68532 6480464 TDO2 gene mutant form results in increased abundance of Tryptophan CTD PMID:32871117 lead diacetate increases expression ISO RGD:68531 6480464 lead acetate results in increased expression of TDO2 mRNA CTD PMID:22839698 lipopolysaccharide increases expression ISO RGD:68531 6480464 Lipopolysaccharides results in increased expression of TDO2 mRNA CTD PMID:20884048 lipopolysaccharide multiple interactions ISO RGD:68532 39939032 lipopolysaccharide increases activity of Tdo2 protein in serum and increases expression of Tdo2 mRNA in liver RGD lipopolysaccharide multiple interactions ISO RGD:68531 6480464 Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TDO2 mRNA] CTD PMID:20884048 medroxyprogesterone acetate multiple interactions ISO RGD:68531 6480464 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [[IFNG protein co-treated with [Medroxyprogesterone Acetate co-treated with Cyclic AMP]] results in increased expression of TDO2 mRNA], [IFNG protein co-treated with [Medroxyprogesterone Acetate co-treated with Cyclic AMP]] results in increased expression of TDO2 mRNA CTD PMID:32781018 melatonin multiple interactions EXP 6480464 [Tolmetin results in decreased activity of TDO2 protein] which results in increased abundance of Melatonin CTD PMID:16952380 metformin decreases expression ISO RGD:68531 6480464 Metformin results in decreased expression of TDO2 mRNA, Metformin results in decreased expression of TDO2 protein CTD PMID:25110054 metformin multiple interactions ISO RGD:68531 6480464 Metformin inhibits the reaction [Dexamethasone results in increased expression of TDO2 mRNA], Metformin inhibits the reaction [Dexamethasone results in increased expression of TDO2 protein] CTD PMID:25110054 methapyrilene decreases expression EXP 6480464 Methapyrilene results in decreased expression of TDO2 mRNA CTD PMID:30467583 methidathion increases expression ISO RGD:68532 6480464 methidathion results in increased expression of TDO2 mRNA CTD PMID:34813904 N-nitrosodiethylamine decreases expression EXP 6480464 Diethylnitrosamine results in decreased expression of TDO2 mRNA CTD PMID:19041683 N-Nitrosopyrrolidine decreases expression ISO RGD:68531 6480464 N-Nitrosopyrrolidine results in decreased expression of TDO2 mRNA CTD PMID:32234424 NADP zwitterion affects abundance EXP 6480464 TDO2 protein affects the abundance of NADP CTD PMID:7306070 NADP(+) affects abundance EXP 6480464 TDO2 protein affects the abundance of NADP CTD PMID:7306070 nickel atom increases expression ISO RGD:68531 6480464 Nickel results in increased expression of TDO2 mRNA CTD PMID:25583101 nitroglycerin decreases expression EXP 6480464 Nitroglycerin results in decreased expression of TDO2 protein CTD PMID:28659861 O-methyleugenol decreases expression ISO RGD:68531 6480464 methyleugenol results in decreased expression of TDO2 mRNA CTD PMID:32234424 ozone increases expression EXP 6480464 Ozone results in increased expression of TDO2 mRNA CTD PMID:35737395 p-chloromercuribenzoic acid increases expression ISO RGD:68531 6480464 p-Chloromercuribenzoic Acid results in increased expression of TDO2 mRNA CTD PMID:26272509 p-chloromercuribenzoic acid multiple interactions ISO RGD:68531 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TDO2 mRNA CTD PMID:27188386 paracetamol decreases expression ISO RGD:68532 6480464 Acetaminophen results in decreased expression of TDO2 mRNA CTD PMID:17585979 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of TDO2 mRNA CTD PMID:17366322 perfluorooctane-1-sulfonic acid decreases expression ISO RGD:68531 6480464 perfluorooctane sulfonic acid results in decreased expression of TDO2 mRNA CTD PMID:27153767 permethrin decreases activity ISO RGD:68532 6480464 Permethrin results in decreased activity of TDO2 protein CTD PMID:2547861 pioglitazone multiple interactions ISO RGD:68532 6480464 [N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of TDO2 mRNA CTD PMID:27935865 pirinixic acid increases expression ISO RGD:68532 6480464 pirinixic acid results in increased expression of TDO2 mRNA CTD PMID:18445702 , PMID:23811191 potassium dichromate decreases expression ISO RGD:68532 6480464 Potassium Dichromate results in decreased expression of TDO2 mRNA CTD PMID:23608068 pregnenolone 16alpha-carbonitrile decreases expression ISO RGD:68532 6480464 Pregnenolone Carbonitrile results in decreased expression of TDO2 mRNA CTD PMID:27413110 progesterone increases expression ISO RGD:68531 6480464 Progesterone results in increased expression of TDO2 mRNA CTD PMID:18070364 propanal increases expression ISO RGD:68531 6480464 propionaldehyde results in increased expression of TDO2 mRNA CTD PMID:26079696 propiconazole decreases expression ISO RGD:68532 6480464 propiconazole results in decreased expression of TDO2 mRNA CTD PMID:21278054 pyridine multiple interactions EXP 6480464 Heme promotes the reaction [pyridine results in increased activity of TDO2 protein] CTD PMID:10413312 quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [Cyclophosphamide results in increased activity of TDO2 protein] CTD PMID:35906875 resveratrol increases expression ISO RGD:68531 6480464 resveratrol results in increased expression of TDO2 mRNA CTD PMID:25888808 rotenone increases expression EXP 6480464 Rotenone results in increased expression of TDO2 mRNA CTD PMID:28374803 SB 431542 multiple interactions ISO RGD:68531 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TDO2 mRNA CTD PMID:27188386 serotonin multiple interactions EXP 6480464 [Sulindac results in decreased activity of TDO2 protein] which results in increased abundance of Serotonin, [Tolmetin results in decreased activity of TDO2 protein] which results in increased abundance of Serotonin CTD PMID:16952380 sevoflurane affects expression EXP 6480464 sevoflurane affects the expression of TDO2 mRNA CTD PMID:15967596 sodium arsenite decreases expression ISO RGD:68531 6480464 sodium arsenite results in decreased expression of TDO2 mRNA CTD PMID:29301061 succimer multiple interactions ISO RGD:68531 6480464 [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of TDO2 mRNA CTD PMID:26378955 sulfasalazine multiple interactions ISO RGD:68531 6480464 Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TDO2 mRNA] CTD PMID:20884048 sulindac decreases activity EXP 6480464 Sulindac results in decreased activity of TDO2 protein CTD PMID:16952380 sulindac multiple interactions EXP 6480464 [Sulindac results in decreased activity of TDO2 protein] which results in decreased abundance of Dopamine, [Sulindac results in decreased activity of TDO2 protein] which results in increased abundance of Serotonin CTD PMID:16952380 tauroursodeoxycholic acid decreases expression EXP 6480464 ursodoxicoltaurine results in decreased expression of TDO2 mRNA CTD PMID:15885361 tetrachloromethane decreases expression ISO RGD:68532 6480464 Carbon Tetrachloride results in decreased expression of TDO2 mRNA CTD PMID:27339419 , PMID:31919559 thioacetamide decreases expression EXP 6480464 Thioacetamide results in decreased expression of TDO2 mRNA CTD PMID:34492290 tolmetin decreases activity EXP 6480464 Tolmetin results in decreased activity of TDO2 protein CTD PMID:16952380 tolmetin multiple interactions EXP 6480464 [Tolmetin results in decreased activity of TDO2 protein] which results in decreased abundance of Dopamine more ... CTD PMID:16952380 triclosan increases expression ISO RGD:68531 6480464 Triclosan results in increased expression of TDO2 mRNA CTD PMID:30510588 valproic acid increases expression ISO RGD:68531 6480464 Valproic Acid results in increased expression of TDO2 mRNA CTD PMID:28001369 XL147 multiple interactions ISO RGD:68532 6480464 [N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of TDO2 mRNA CTD PMID:27935865
