Ppp1r3b (protein phosphatase 1, regulatory subunit 3B) - Rat Genome Database

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Gene: Ppp1r3b (protein phosphatase 1, regulatory subunit 3B) Rattus norvegicus
Analyze
Symbol: Ppp1r3b
Name: protein phosphatase 1, regulatory subunit 3B
RGD ID: 621600
Description: Enables [phosphorylase] phosphatase activity; enzyme binding activity; and protein phosphatase regulator activity. Contributes to phosphoprotein phosphatase activity. Involved in regulation of glycogen biosynthetic process and regulation of glycogen catabolic process. Located in glycogen granule and intracellular membrane-bounded organelle. Part of protein phosphatase type 1 complex. Orthologous to human PPP1R3B (protein phosphatase 1 regulatory subunit 3B); PARTICIPATES IN glycogen biosynthetic pathway; glycogen degradation pathway; insulin signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 33 kDa glycogen-binding protein; hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL; Loc192280; PP1 subunit R4; protein phosphatase 1 (GL-subunit); protein phosphatase 1 regulatory subunit 3B; protein phosphatase 1 regulatory subunit 4; protein phosphatase 1 subunit GL; protein phosphatase 1, regulatory (inhibitor) subunit 3B; R4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21656,830,011 - 56,842,395 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1656,829,660 - 56,842,406 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1662,142,204 - 62,154,551 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01665,556,188 - 65,568,535 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01660,776,161 - 60,788,508 (-)NCBIRnor_WKY
Rnor_6.01660,415,192 - 60,427,498 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1660,415,229 - 60,427,474 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01660,089,230 - 60,101,526 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41660,552,431 - 60,564,789 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11660,552,514 - 60,564,864 (-)NCBI
Celera1654,879,618 - 54,891,875 (-)NCBICelera
Cytogenetic Map16q12.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
carbon nanotube  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dichloroacetic acid  (ISO)
diethyl maleate  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
fenvalerate  (EXP)
fluoranthene  (ISO)
furan  (EXP)
gentamycin  (EXP)
hydrogen cyanide  (ISO)
indometacin  (ISO)
kenpaullone  (EXP)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP)
nickel dichloride  (ISO)
nimesulide  (EXP)
O-methyleugenol  (ISO)
oxaliplatin  (EXP)
panobinostat  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
permethrin  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
potassium cyanide  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The level of the glycogen targetting regulatory subunit R5 of protein phosphatase 1 is decreased in the livers of insulin-dependent diabetic rats and starved rats. Browne GJ, etal., Biochem J. 2001 Dec 1;360(Pt 2):449-59.
2. Functional diversity of protein phosphatase-1, a cellular economizer and reset button. Ceulemans H and Bollen M, Physiol Rev. 2004 Jan;84(1):1-39.
3. Amino acid sequence and expression of the hepatic glycogen-binding (GL)-subunit of protein phosphatase-1. Doherty MJ, etal., FEBS Lett 1995 Nov 20;375(3):294-8.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Purification of the hepatic glycogen-associated form of protein phosphatase-1 by microcystin-Sepharose affinity chromatography. Moorhead G, etal., FEBS Lett. 1995 Apr 3;362(2):101-5.
7. A novel glycogen-targeting subunit of protein phosphatase 1 that is regulated by insulin and shows differential tissue distribution in humans and rodents. Munro S, etal., FEBS J. 2005 Mar;272(6):1478-89.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:18298402   PMID:22225877  


Genomics

Comparative Map Data
Ppp1r3b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21656,830,011 - 56,842,395 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1656,829,660 - 56,842,406 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1662,142,204 - 62,154,551 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01665,556,188 - 65,568,535 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01660,776,161 - 60,788,508 (-)NCBIRnor_WKY
Rnor_6.01660,415,192 - 60,427,498 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1660,415,229 - 60,427,474 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01660,089,230 - 60,101,526 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41660,552,431 - 60,564,789 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11660,552,514 - 60,564,864 (-)NCBI
Celera1654,879,618 - 54,891,875 (-)NCBICelera
Cytogenetic Map16q12.2NCBI
PPP1R3B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3889,136,255 - 9,151,539 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl89,136,255 - 9,151,574 (-)EnsemblGRCh38hg38GRCh38
GRCh3788,993,765 - 9,009,049 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3689,031,175 - 9,045,630 (-)NCBINCBI36Build 36hg18NCBI36
Build 3489,032,915 - 9,045,616NCBI
Celera88,122,001 - 8,136,452 (-)NCBICelera
Cytogenetic Map8p23.1NCBI
HuRef87,918,908 - 7,934,297 (-)NCBIHuRef
CHM1_189,059,097 - 9,074,486 (-)NCBICHM1_1
T2T-CHM13v2.0810,592,540 - 10,607,824 (+)NCBIT2T-CHM13v2.0
Ppp1r3b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39835,842,847 - 35,855,293 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl835,842,893 - 35,855,293 (+)EnsemblGRCm39 Ensembl
GRCm38835,375,694 - 35,388,139 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl835,375,739 - 35,388,139 (+)EnsemblGRCm38mm10GRCm38
MGSCv37836,438,795 - 36,451,193 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36836,844,258 - 36,856,656 (+)NCBIMGSCv36mm8
Celera838,013,471 - 38,026,084 (+)NCBICelera
Cytogenetic Map8A4NCBI
Ppp1r3b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554635,208,149 - 5,220,970 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554635,208,127 - 5,220,970 (-)NCBIChiLan1.0ChiLan1.0
PPP1R3B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v0810,059,531 - 10,074,820 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PPP1R3B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11635,372,928 - 35,384,640 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1635,372,859 - 35,381,921 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1635,837,710 - 35,849,122 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01637,404,755 - 37,416,979 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1637,406,741 - 37,416,415 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11635,510,292 - 35,522,176 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01636,073,646 - 36,085,794 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01636,192,990 - 36,204,446 (+)NCBIUU_Cfam_GSD_1.0
Ppp1r3b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494343,778,857 - 43,791,311 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365731,351,207 - 1,363,639 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1R3B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1556,002,378 - 56,013,478 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11556,002,383 - 56,013,477 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21563,426,353 - 63,437,318 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPP1R3B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.189,912,834 - 9,924,510 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl89,922,735 - 9,923,592 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605232,467,916 - 32,482,055 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp1r3b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248395,228,674 - 5,240,816 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248395,228,674 - 5,240,808 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
AU048745  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q32UniSTS
Cytogenetic Map13q24UniSTS
Cytogenetic Map6q32UniSTS
Cytogenetic Map17p12UniSTS
Cytogenetic Map16p14UniSTS
Cytogenetic Map13q26UniSTS
Cytogenetic Map10q22UniSTS
Cytogenetic Map7q11UniSTS
Cytogenetic Map8q24UniSTS
Cytogenetic Map5q21UniSTS
Cytogenetic Map4q24UniSTS
Cytogenetic Map2q11UniSTS
Cytogenetic Map1q54UniSTS
Cytogenetic Map1q36UniSTS
Cytogenetic Map18p11UniSTS
Cytogenetic Map13q13UniSTS
Cytogenetic Map10q24UniSTS
Cytogenetic Map8q31UniSTS
Cytogenetic Map3q21UniSTS
Cytogenetic Map13p13UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map11q23UniSTS
Cytogenetic Map10q31UniSTS
Cytogenetic Map16q12.2UniSTS
Cytogenetic Map3q24UniSTS
Cytogenetic Map5q36UniSTS
Cytogenetic Map3p13UniSTS
RH143497  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21656,832,004 - 56,832,120 (+)MAPPERmRatBN7.2
Rnor_6.01660,417,186 - 60,417,301NCBIRnor6.0
Rnor_5.01660,091,224 - 60,091,339UniSTSRnor5.0
RGSC_v3.41660,554,399 - 60,554,514UniSTSRGSC3.4
Celera1654,881,586 - 54,881,701UniSTS
RH 3.4 Map16542.51UniSTS
Cytogenetic Map16q12.2UniSTS
BE113230  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21656,840,640 - 56,840,822 (+)MAPPERmRatBN7.2
Rnor_6.01660,425,720 - 60,425,901NCBIRnor6.0
Rnor_5.01660,099,758 - 60,099,939UniSTSRnor5.0
RGSC_v3.41660,563,035 - 60,563,216UniSTSRGSC3.4
Celera1654,890,121 - 54,890,302UniSTS
RH 3.4 Map16559.2UniSTS
Cytogenetic Map16q12.2UniSTS
PMC154451P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21656,833,838 - 56,834,072 (+)MAPPERmRatBN7.2
Rnor_6.01660,419,020 - 60,419,253NCBIRnor6.0
Rnor_5.01660,093,058 - 60,093,291UniSTSRnor5.0
RGSC_v3.41660,556,233 - 60,556,466UniSTSRGSC3.4
Celera1654,883,420 - 54,883,653UniSTS
Cytogenetic Map16q12.2UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)163195152060148445Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:479
Count of miRNA genes:252
Interacting mature miRNAs:327
Transcripts:ENSRNOT00000051720
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 26 41 27 6 27 16 19 10
Low 3 17 16 14 13 14 8 11 74 19 22 1 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000051720   ⟹   ENSRNOP00000042713
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1656,829,660 - 56,842,406 (-)Ensembl
Rnor_6.0 Ensembl1660,415,229 - 60,427,474 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000082091   ⟹   ENSRNOP00000070738
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1660,418,423 - 60,426,561 (-)Ensembl
RefSeq Acc Id: NM_138912   ⟹   NP_620267
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21656,830,037 - 56,842,395 (-)NCBI
Rnor_6.01660,415,218 - 60,427,474 (-)NCBI
Rnor_5.01660,089,230 - 60,101,526 (-)NCBI
RGSC_v3.41660,552,431 - 60,564,789 (-)RGD
Celera1654,879,618 - 54,891,875 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253215   ⟹   XP_006253277
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21656,830,011 - 56,842,169 (-)NCBI
Rnor_6.01660,415,192 - 60,427,265 (-)NCBI
Rnor_5.01660,089,230 - 60,101,526 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253216   ⟹   XP_006253278
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21656,830,011 - 56,842,393 (-)NCBI
Rnor_6.01660,415,192 - 60,427,498 (-)NCBI
Rnor_5.01660,089,230 - 60,101,526 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_620267   ⟸   NM_138912
- UniProtKB: Q63759 (UniProtKB/Swiss-Prot),   Q6IN01 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006253278   ⟸   XM_006253216
- Peptide Label: isoform X1
- UniProtKB: Q63759 (UniProtKB/Swiss-Prot),   Q6IN01 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006253277   ⟸   XM_006253215
- Peptide Label: isoform X1
- UniProtKB: Q63759 (UniProtKB/Swiss-Prot),   Q6IN01 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070738   ⟸   ENSRNOT00000082091
RefSeq Acc Id: ENSRNOP00000042713   ⟸   ENSRNOT00000051720
Protein Domains
CBM21

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6IN01-F1-model_v2 AlphaFold Q6IN01 1-284 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700142
Promoter ID:EPDNEW_R10657
Type:multiple initiation site
Name:Ppp1r3b_1
Description:protein phosphatase 1, regulatory subunit 3B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10658  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01660,426,588 - 60,426,648EPDNEW
RGD ID:13700134
Promoter ID:EPDNEW_R10658
Type:initiation region
Name:Ppp1r3b_2
Description:protein phosphatase 1, regulatory subunit 3B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10657  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01660,427,438 - 60,427,498EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
16 60093278 60093279 G A snv BDIX/NemOda (KyushuU), BDIX.Cg-Tal/NemOda (KyushuU), DOB/Oda (KyushuU)


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
16 60555864 60555865 T G snv LCR/1Mco (UMich)
16 60555870 60555871 C A snv LCR/1Mco (UMich)
16 60555888 60555889 T G snv LCR/1Mco (UMich)
16 60556213 60556214 C T snv LCR/2Mco (UMich), LCR/1Mco (UMich), HCR/1Mco (UMich), SHRSP/Gcrc (MDC), HCR/2Mco (UMich)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621600 AgrOrtholog
BioCyc Gene G2FUF-11159 BioCyc
Ensembl Genes ENSRNOG00000011474 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000042713 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000051720 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.2440 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7104413 IMAGE-MGC_LOAD
InterPro CBM21_dom UniProtKB/Swiss-Prot
  CBM21_dom_sf UniProtKB/Swiss-Prot
  Pase-1_reg-su_3B/C/D_met UniProtKB/Swiss-Prot
  PP1_3B UniProtKB/Swiss-Prot
KEGG Report rno:192280 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91481 IMAGE-MGC_LOAD
NCBI Gene 192280 ENTREZGENE
PANTHER PTHR12307:SF13 UniProtKB/Swiss-Prot
Pfam CBM_21 UniProtKB/Swiss-Prot
PhenoGen Ppp1r3b PhenoGen
PIRSF PP1_GL UniProtKB/Swiss-Prot
  PP1_GT_animal UniProtKB/Swiss-Prot
PROSITE CBM21 UniProtKB/Swiss-Prot
UniProt PPR3B_RAT UniProtKB/Swiss-Prot
  Q63759 ENTREZGENE
  Q6IN01 ENTREZGENE
UniProt Secondary Q63759 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-10-18 Ppp1r3b  protein phosphatase 1, regulatory subunit 3B  Ppp1r3b  protein phosphatase 1, regulatory (inhibitor) subunit 3B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Ppp1r3b  protein phosphatase 1, regulatory (inhibitor) subunit 3B  Loc192280  protein phosphatase 1 (GL-subunit)  Symbol and Name updated 1299863 APPROVED
2002-08-07 Loc192280  protein phosphatase 1 (GL-subunit)      Symbol and Name status set to provisional 70820 PROVISIONAL