Map2k3 (mitogen activated protein kinase kinase 3) - Rat Genome Database

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Gene: Map2k3 (mitogen activated protein kinase kinase 3) Rattus norvegicus
Analyze
Symbol: Map2k3
Name: mitogen activated protein kinase kinase 3
RGD ID: 1306620
Description: Predicted to enable MAP kinase kinase activity and protein kinase binding activity. Involved in several processes, including cellular response to sorbitol; positive regulation of macromolecule metabolic process; and response to ischemia. Located in cytosol. Used to study retinal disease. Human ortholog(s) of this gene implicated in cervical cancer and restrictive cardiomyopathy. Orthologous to human MAP2K3 (mitogen-activated protein kinase kinase 3); PARTICIPATES IN p38 MAPK signaling pathway; Fc epsilon receptor mediated signaling pathway; interleukin-12 signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dual specificity mitogen-activated protein kinase kinase 3; dual specificity mitogen-activated protein kinase kinase 3-like; LOC100911550; LOC108348082; LOC303200; Mek3; Mkk3
RGD Orthologs
Human
Mouse
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21045,608,145 - 45,629,492 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1045,607,163 - 45,629,492 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1050,310,306 - 50,331,733 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01049,800,693 - 49,822,120 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01045,304,279 - 45,325,706 (+)NCBIRnor_WKY
Rnor_6.01045,089,455 - 45,110,802 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1047,182,433 - 47,203,753 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1045,089,464 - 45,110,787 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01044,847,090 - 44,868,491 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41047,075,270 - 47,096,617NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1044,862,946 - 44,884,272 (+)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4-hydroxyphenyl retinamide  (ISO)
9-cis,11-trans-octadecadienoic acid  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
AM-251  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Azaspiracid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP,ISO)
camptothecin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
daunorubicin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dicrotophos  (ISO)
dinophysistoxin 1  (ISO)
disulfiram  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glyphosate  (ISO)
hydralazine  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
josamycin  (ISO)
L-ascorbic acid  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
malathion  (ISO)
manganese(II) chloride  (ISO)
metformin  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
monosodium L-glutamate  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (EXP)
nimesulide  (EXP)
Nonylphenol  (ISO)
obeticholic acid  (ISO)
okadaic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selenium atom  (ISO)
senecionine  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
tributylstannane  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

References

References - curated
# Reference Title Reference Citation
1. p38 MAP-kinases pathway regulation, function and role in human diseases. Cuenda A and Rousseau S, Biochim Biophys Acta. 2007 Aug;1773(8):1358-75. Epub 2007 Mar 24.
2. MAP-ing glioma invasion: mitogen-activated protein kinase kinase 3 and p38 drive glioma invasion and progression and predict patient survival. Demuth T, etal., Mol Cancer Ther. 2007 Apr;6(4):1212-22. Epub 2007 Apr 3.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Both p38alpha(MAPK) and JNK/SAPK pathways are important for induction of nitric-oxide synthase by interleukin-1beta in rat glomerular mesangial cells. Guan Z, etal., J Biol Chem. 1999 Dec 17;274(51):36200-6.
6. Activation of ASK1, downstream MAPKK and MAPK isoforms during cardiac ischaemia. Harding SJ, etal., Biochim Biophys Acta. 2010 Sep;1802(9):733-40. doi: 10.1016/j.bbadis.2010.06.005. Epub 2010 Jun 13.
7. Thioredoxin inhibits NMDA-induced neurotoxicity in the rat retina. Inomata Y, etal., J Neurochem. 2006 Jul;98(2):372-85.
8. Effects of sodium ferulate on amyloid-beta-induced MKK3/MKK6-p38 MAPK-Hsp27 signal pathway and apoptosis in rat hippocampus. Jin Y, etal., Acta Pharmacol Sin. 2006 Oct;27(10):1309-16.
9. p38 MAPK and MAPK kinase 3/6 mRNA and activities are increased in early diabetic glomeruli. Kang SW, etal., Kidney Int. 2001 Aug;60(2):543-52.
10. Lipopolysaccharide induces CYP2E1 in astrocytes through MAP kinase kinase-3 and C/EBPbeta and -delta. Kelicen P and Tindberg N, J Biol Chem. 2004 Apr 16;279(16):15734-42. Epub 2003 Dec 11.
11. Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart. Kim SO, etal., J Cell Biochem 1998 Nov 1;71(2):286-301.
12. p38 kinase is crucial for osteopontin-induced furin expression that supports cervical cancer progression. Kumar V, etal., Cancer Res. 2010 Dec 15;70(24):10381-91. doi: 10.1158/0008-5472.CAN-10-1470. Epub 2010 Oct 27.
13. The nNOS-p38MAPK pathway is mediated by NOS1AP during neuronal death. Li LL, etal., J Neurosci. 2013 May 8;33(19):8185-201. doi: 10.1523/JNEUROSCI.4578-12.2013.
14. The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy. Liao P, etal., Proc Natl Acad Sci U S A 2001 Oct 9;98(21):12283-8. Epub 2001 Oct 02.
15. MAPK kinase 3 is a tumor suppressor with reduced copy number in breast cancer. Macneil AJ, etal., Cancer Res. 2013 Nov 14.
16. Activation of TGF-beta1-TAK1-p38 MAPK pathway in spared cardiomyocytes is involved in left ventricular remodeling after myocardial infarction in rats. Matsumoto-Ida M, etal., Am J Physiol Heart Circ Physiol. 2006 Feb;290(2):H709-15. Epub 2005 Sep 23.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
20. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
21. GOA pipeline RGD automated data pipeline
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Comprehensive gene review and curation RGD comprehensive gene curation
24. MKK3, an upstream activator of p38, contributes to formalin phase 2 and late allodynia in mice. Sorkin LS, etal., Neuroscience. 2009 Aug 18;162(2):462-71. doi: 10.1016/j.neuroscience.2009.05.008. Epub 2009 May 8.
25. Opposite effect of JAK2 on insulin-dependent activation of mitogen-activated protein kinases and Akt in muscle cells: possible target to ameliorate insulin resistance. Thirone AC, etal., Diabetes. 2006 Apr;55(4):942-51.
26. Nonparticipation of nuclear factor kappa B (NFkappaB) in the signaling cascade of c-Jun N-terminal kinase (JNK)- and p38 mitogen-activated protein kinase (p38MAPK)-dependent tumor necrosis factor alpha (TNFalpha) induction in lipopolysaccharide (LPS)-stimulated microglia. Uesugi M, etal., Brain Res. 2006 Feb 16;1073-1074:48-59. Epub 2006 Feb 2.
27. Overexpression of mitogen-activated protein kinase phosphatases MKP1, MKP2 in human breast cancer. Wang HY, etal., Cancer Lett. 2003 Mar 10;191(2):229-37.
28. Emodin suppresses interleukin-1beta induced mesangial cells proliferation and extracellular matrix production via inhibiting P38 MAPK. Wang R, etal., Life Sci. 2007 Jun 6;80(26):2481-8. Epub 2007 Apr 21.
Additional References at PubMed
PMID:8900184   PMID:10097111   PMID:10202148   PMID:11279118   PMID:11980910   PMID:12477932   PMID:14709549   PMID:15767678   PMID:16407200   PMID:18948261   PMID:19946888   PMID:21981804  
PMID:22696064   PMID:27402810   PMID:28739872   PMID:29197828   PMID:31505169  


Genomics

Comparative Map Data
Map2k3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21045,608,145 - 45,629,492 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1045,607,163 - 45,629,492 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1050,310,306 - 50,331,733 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01049,800,693 - 49,822,120 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01045,304,279 - 45,325,706 (+)NCBIRnor_WKY
Rnor_6.01045,089,455 - 45,110,802 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1047,182,433 - 47,203,753 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1045,089,464 - 45,110,787 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01044,847,090 - 44,868,491 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41047,075,270 - 47,096,617NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1044,862,946 - 44,884,272 (+)NCBICelera
Cytogenetic Map10q22NCBI
MAP2K3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381721,284,711 - 21,315,240 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1721,284,672 - 21,315,232 (+)EnsemblGRCh38hg38GRCh38
GRCh371721,188,023 - 21,218,552 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361721,128,561 - 21,159,145 (+)NCBINCBI36Build 36hg18NCBI36
Build 341721,141,910 - 21,158,870NCBI
Cytogenetic Map17p11.2NCBI
HuRef1720,389,899 - 20,420,519 (+)NCBIHuRef
CHM1_11721,197,569 - 21,228,147 (+)NCBICHM1_1
T2T-CHM13v2.01721,233,611 - 21,264,159 (+)NCBIT2T-CHM13v2.0
Map2k3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391160,822,880 - 60,843,637 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1160,822,859 - 60,843,637 (+)EnsemblGRCm39 Ensembl
GRCm381160,932,054 - 60,952,811 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1160,932,033 - 60,952,811 (+)EnsemblGRCm38mm10GRCm38
MGSCv371160,745,559 - 60,766,305 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361160,748,252 - 60,768,998 (+)NCBIMGSCv36mm8
Celera1165,171,267 - 65,191,964 (+)NCBICelera
Cytogenetic Map11B2NCBI
Map2k3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555771,237,287 - 1,248,541 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555771,225,033 - 1,249,510 (+)NCBIChiLan1.0ChiLan1.0
MAP2K3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1542,732,751 - 42,762,420 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl542,700,836 - 42,761,736 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha542,870,421 - 42,900,078 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0542,839,802 - 42,869,464 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl542,839,790 - 42,869,343 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1542,806,533 - 42,836,183 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0542,753,555 - 42,783,186 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0542,946,459 - 42,976,119 (+)NCBIUU_Cfam_GSD_1.0
Map2k3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560262,480,582 - 62,504,527 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936741362,387 - 386,678 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936741362,682 - 386,633 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP2K3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1261,396,369 - 61,417,321 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11261,396,337 - 61,417,333 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MAP2K3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11619,396,377 - 19,427,617 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1619,396,452 - 19,427,652 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660591,327,045 - 1,358,833 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map2k3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248495,006,513 - 5,035,747 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248495,007,185 - 5,034,488 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Map2k3
169 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:840
Count of miRNA genes:307
Interacting mature miRNAs:400
Transcripts:ENSRNOT00000008679, ENSRNOT00000073792
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat

Markers in Region
RH128171  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21045,629,272 - 45,629,460 (+)MAPPERmRatBN7.2
Rnor_6.01047,203,561 - 47,203,748NCBIRnor6.0
Rnor_6.01045,110,583 - 45,110,770NCBIRnor6.0
Rnor_5.01044,868,272 - 44,868,459UniSTSRnor5.0
Rnor_5.01046,977,037 - 46,977,224UniSTSRnor5.0
RGSC_v3.41047,096,398 - 47,096,585UniSTSRGSC3.4
Celera1044,884,053 - 44,884,240UniSTS
Cytogenetic Map10q22UniSTS
MAP2K3_360  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21045,628,417 - 45,629,369 (+)MAPPERmRatBN7.2
Rnor_6.01047,202,706 - 47,203,657NCBIRnor6.0
Rnor_6.01045,109,728 - 45,110,679NCBIRnor6.0
Rnor_5.01044,867,417 - 44,868,368UniSTSRnor5.0
Rnor_5.01046,976,182 - 46,977,133UniSTSRnor5.0
RGSC_v3.41047,095,543 - 47,096,494UniSTSRGSC3.4
Celera1044,883,198 - 44,884,149UniSTS
Cytogenetic Map10q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 2 1 4 1 1 2 1
Below cutoff 22 48 33 14 33 7 9 13 35 28 9 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008679   ⟹   ENSRNOP00000008679
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1045,607,163 - 45,629,492 (+)Ensembl
Rnor_6.0 Ensembl1047,182,433 - 47,203,753 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000073792   ⟹   ENSRNOP00000065373
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1045,608,025 - 45,629,492 (+)Ensembl
Rnor_6.0 Ensembl1045,089,464 - 45,110,787 (+)Ensembl
RefSeq Acc Id: NM_001100674   ⟹   NP_001094144
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21045,608,145 - 45,629,492 (+)NCBI
Rnor_6.01045,089,455 - 45,110,802 (+)NCBI
Rnor_5.01044,847,090 - 44,868,491 (+)NCBI
RGSC_v3.41047,075,270 - 47,096,617 (+)RGD
Celera1044,862,946 - 44,884,272 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001094144 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI00096 (Get FASTA)   NCBI Sequence Viewer  
  AAI60839 (Get FASTA)   NCBI Sequence Viewer  
  EDM04672 (Get FASTA)   NCBI Sequence Viewer  
  EDM04673 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001094144   ⟸   NM_001100674
- UniProtKB: B1H230 (UniProtKB/TrEMBL),   Q498S1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008679   ⟸   ENSRNOT00000008679
RefSeq Acc Id: ENSRNOP00000065373   ⟸   ENSRNOT00000073792
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B1H230-F1-model_v2 AlphaFold B1H230 1-347 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306620 AgrOrtholog
BioCyc Gene G2FUF-24830 BioCyc
Ensembl Genes ENSRNOG00000006612 Ensembl
  ENSRNOG00000049132 Ensembl
  ENSRNOG00000065992 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000008679.6 UniProtKB/TrEMBL
  ENSRNOP00000065373 ENTREZGENE
  ENSRNOP00000065373.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008679.8 UniProtKB/TrEMBL
  ENSRNOT00000073792 ENTREZGENE
  ENSRNOT00000073792.3 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7374925 IMAGE-MGC_LOAD
  IMAGE:7458293 IMAGE-MGC_LOAD
InterPro Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:303200 UniProtKB/TrEMBL
MGC_CLONE MGC:112819 IMAGE-MGC_LOAD
  MGC:187561 IMAGE-MGC_LOAD
NCBI Gene 303200 ENTREZGENE
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Map2k3 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt B1H230 ENTREZGENE, UniProtKB/TrEMBL
  F7EXM7_RAT UniProtKB/TrEMBL
  M0R7E7_RAT UniProtKB/TrEMBL
  Q498S1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Map2k3  mitogen activated protein kinase kinase 3  LOC108348082  dual specificity mitogen-activated protein kinase kinase 3-like  Data Merged 737654 PROVISIONAL
2016-08-02 LOC108348082  dual specificity mitogen-activated protein kinase kinase 3-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2015-07-29 Map2k3  mitogen activated protein kinase kinase 3  LOC100911550  dual specificity mitogen-activated protein kinase kinase 3-like  Data Merged 737654 PROVISIONAL
2012-07-05 LOC100911550  dual specificity mitogen-activated protein kinase kinase 3-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-12-06 Map2k3  mitogen activated protein kinase kinase 3  Map2k3_predicted  mitogen activated protein kinase kinase 3 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Map2k3_predicted  mitogen activated protein kinase kinase 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED