Tlr3 (toll-like receptor 3) - Rat Genome Database

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Gene: Tlr3 (toll-like receptor 3) Rattus norvegicus
Symbol: Tlr3
Name: toll-like receptor 3
RGD ID: 735171
Description: Enables double-stranded RNA binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to exogenous dsRNA; and microglial cell activation. Located in cell surface. Used to study asthma. Biomarker of colitis; pancreatitis; perinatal necrotizing enterocolitis; peripheral nervous system disease; and pre-eclampsia. Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; human immunodeficiency virus infectious disease; liver cirrhosis; and primary immunodeficiency disease (multiple). Orthologous to human TLR3 (toll like receptor 3); PARTICIPATES IN Toll-like receptor signaling pathway; hepatitis C pathway; influenza A pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81653,554,916 - 53,572,321 (+)NCBIGRCr8
mRatBN7.21646,821,980 - 46,837,900 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1646,822,039 - 46,836,545 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1652,215,759 - 52,229,258 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01655,592,446 - 55,605,923 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01650,855,155 - 50,868,654 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01650,016,466 - 50,031,011 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1650,016,857 - 50,031,214 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01649,739,814 - 49,753,968 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41650,112,910 - 50,126,371 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11650,112,984 - 50,126,440 (+)NCBI
Celera1644,813,138 - 44,826,566 (+)NCBICelera
Cytogenetic Map16q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
1-Aminopyrene  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dinitrotoluene  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aripiprazole  (ISO)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP)
cadmium selenide  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
chlorogenic acid  (ISO)
chloroquine  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cyanidin cation  (EXP,ISO)
cyclosporin A  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
GW 4064  (ISO)
hydroquinone  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
metam  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methotrexate  (EXP,ISO)
methoxychlor  (EXP)
nickel sulfate  (ISO)
nitrates  (EXP)
o-anisidine  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (EXP,ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
pristane  (EXP)
pyrene  (ISO)
quinacrine  (ISO)
resveratrol  (ISO)
ruxolitinib  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium aurothiosulfate  (ISO)
sotorasib  (ISO)
streptozocin  (ISO)
Sunset Yellow FCF  (ISO)
tartrazine  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to exogenous dsRNA  (IEP,IMP,ISO)
cellular response to interferon-beta  (IEP)
cellular response to mechanical stimulus  (ISO)
cellular response to type II interferon  (IEP)
cellular response to virus  (ISO)
cellular response to xenobiotic stimulus  (IEP)
defense response  (ISO)
defense response to virus  (ISO)
extrinsic apoptotic signaling pathway  (ISO)
inflammatory response  (IBA)
inflammatory response to wounding  (ISO)
JNK cascade  (ISO)
male gonad development  (IEP)
MAPK cascade  (ISO)
microglial cell activation  (IDA)
necroptotic signaling pathway  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of apoptotic process  (IEP)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cytokine production involved in inflammatory response  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of interferon-alpha production  (ISO)
positive regulation of interferon-beta production  (ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of macrophage cytokine production  (ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type I interferon production  (ISO)
positive regulation of type II interferon production  (ISO)
positive regulation of type III interferon production  (ISO)
regulation of dendritic cell cytokine production  (ISO)
response to dsRNA  (IDA)
response to exogenous dsRNA  (ISO)
response to virus  (ISO)
toll-like receptor 3 signaling pathway  (ISO)
toll-like receptor signaling pathway  (IBA,IDA,ISO)
type III interferon production  (ISO)

Cellular Component
cell surface  (IDA,ISO)
cytoplasm  (ISO)
early endosome  (ISO)
plasma membrane  (IBA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Toll-like receptor 3 gene expression in Egyptian patients with glomerulonephritis and hepatitis C virus infection. Abou-Zeid AA and El-Sayegh HK, Scand J Clin Lab Invest. 2011 Oct;71(6):456-61. doi: 10.3109/00365513.2011.585660. Epub 2011 May 30.
2. Toll-like receptor 3 polymorphism and its association with hepatitis B virus infection in Saudi Arabian patients. Al-Qahtani A, etal., J Med Virol. 2012 Sep;84(9):1353-9. doi: 10.1002/jmv.23271.
3. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Alexopoulou L, etal., Nature 2001 Oct 18;413(6857):732-8.
4. Identification of Toll-like receptors in the rat (Rattus norvegicus): messenger RNA expression in the male reproductive tract under conditions of androgen variation. Biswas B, etal., Am J Reprod Immunol. 2009 Oct;62(4):243-52. Epub 2009 Aug 24.
5. Activation of toll-like receptor 3 attenuates alcoholic liver injury by stimulating Kupffer cells and stellate cells to produce interleukin-10 in mice. Byun JS, etal., J Hepatol. 2013 Feb;58(2):342-9. doi: 10.1016/j.jhep.2012.09.016. Epub 2012 Sep 27.
6. Toll-like receptor 3 expressing tumor parenchyma and infiltrating natural killer cells in hepatocellular carcinoma patients. Chew V, etal., J Natl Cancer Inst. 2012 Dec 5;104(23):1796-807. doi: 10.1093/jnci/djs436. Epub 2012 Nov 29.
7. Rapidity of fibrosis progression in liver transplant recipients with recurrent hepatitis C is influenced by toll-like receptor 3 polymorphism. Citores MJ, etal., Clin Transplant. 2016 Jul;30(7):810-8. doi: 10.1111/ctr.12754. Epub 2016 May 23.
8. Association between toll-like receptor expression and human papillomavirus type 16 persistence. Daud II, etal., Int J Cancer. 2011 Feb 15;128(4):879-86. doi: 10.1002/ijc.25400.
9. The association of single nucleotide polymorphisms of Toll-like receptor 3, Toll-like receptor 7 and Toll-like receptor 8 genes with the susceptibility to HCV infection. El-Bendary M, etal., Br J Biomed Sci. 2018 Oct;75(4):175-181. doi: 10.1080/09674845.2018.1492186. Epub 2018 Aug 23.
10. Polymorphisms in the Toll-like receptor 3 (TLR3) gene are associated with the natural course of hepatitis B virus infection in Caucasian population. Fischer J, etal., Sci Rep. 2018 Aug 24;8(1):12737. doi: 10.1038/s41598-018-31065-6.
11. Up-regulation of Toll-like receptors 2, 3 and 4 in allergic rhinitis. Fransson M, etal., Respir Res. 2005 Sep 7;6:100.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Pre-activation of TLR3 enhances the therapeutic effect of BMMSCs through regulation the intestinal HIF-2α signaling pathway and balance of NKB cells in experimental alcoholic liver injury. Ge L, etal., Int Immunopharmacol. 2019 May;70:477-485. doi: 10.1016/j.intimp.2019.02.021. Epub 2019 Mar 12.
14. A murine model of mixed connective tissue disease induced with U1 small nuclear RNP autoantigen. Greidinger EL, etal., Arthritis Rheum. 2006 Feb;54(2):661-9.
15. Combinations of TLR and NOD2 ligands stimulate rat microglial P2X4R expression. Guo LH, etal., Biochem Biophys Res Commun. 2006 Oct 27;349(3):1156-62. Epub 2006 Sep 1.
16. Association of Toll-like receptor 3 and Toll-like receptor 9 single-nucleotide polymorphisms with hepatitis C virus persistence among Egyptians. Hamdy S, etal., Arch Virol. 2018 Sep;163(9):2433-2442. doi: 10.1007/s00705-018-3893-8. Epub 2018 Jun 2.
17. Thyrocytes express a functional toll-like receptor 3: overexpression can be induced by viral infection and reversed by phenylmethimazole and is associated with Hashimoto's autoimmune thyroiditis. Harii N, etal., Mol Endocrinol. 2005 May;19(5):1231-50. Epub 2005 Jan 20.
18. A tropomyosine receptor kinase inhibitor blocks spinal neuroplasticity essential for the anti-hypersensitivity effects of gabapentin and clonidine in rats with peripheral nerve injury. Hayashida K and Eisenach JC, J Pain. 2011 Jan;12(1):94-100.
19. Epithelial Cells From Smokers Modify Dendritic Cell Responses in the Context of Influenza Infection. Horvath KM, etal., Am J Respir Cell Mol Biol. 2010 Oct 8.
20. Genetic polymorphisms in Toll-like receptor 3 gene are associated with the risk of hepatitis B virus-related liver diseases in a Chinese population. Huang X, etal., Gene. 2015 Sep 15;569(2):218-24. doi: 10.1016/j.gene.2015.05.054. Epub 2015 May 27.
21. TLR3 increases disease morbidity and mortality from vaccinia infection. Hutchens M, etal., J Immunol. 2008 Jan 1;180(1):483-91.
22. TH2 and TH1 lung inflammation induced by airway allergen sensitization with low and high doses of double-stranded RNA. Jeon SG, etal., J Allergy Clin Immunol. 2007 Oct;120(4):803-12. Epub 2007 Jul 5.
23. TLR3 modulates immunopathology during a Schistosoma mansoni egg-driven Th2 response in the lung. Joshi AD, etal., Eur J Immunol. 2008 Dec;38(12):3436-49.
24. Melatonin protects liver against ischemia and reperfusion injury through inhibition of toll-like receptor signaling pathway. Kang JW, etal., J Pineal Res. 2011 Feb 28. doi: 10.1111/j.1600-079X.2011.00858.x.
25. Cigarette smoke selectively enhances viral PAMP- and virus-induced pulmonary innate immune and remodeling responses in mice. Kang MJ, etal., J Clin Invest. 2008 Aug;118(8):2771-84.
26. Down regulation of TRIF, TLR3, and MAVS in HCV infected liver correlates with the outcome of infection. Kar P, etal., J Med Virol. 2017 Dec;89(12):2165-2172. doi: 10.1002/jmv.24849. Epub 2017 Sep 4.
27. Pathogen recognition by the innate immune system. Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34.
28. Detrimental contribution of the Toll-like receptor (TLR)3 to influenza A virus-induced acute pneumonia. Le Goffic R, etal., PLoS Pathog. 2006 Jun;2(6):e53. Epub 2006 Jun 9.
29. Association between a functional polymorphism in Toll-like receptor 3 and chronic hepatitis C in liver transplant recipients. Lee SO, etal., Transpl Infect Dis. 2013 Apr;15(2):111-9. doi: 10.1111/tid.12033. Epub 2012 Dec 13.
30. Higher expression of Toll-like receptors 2, 3, 4, and 8 in ocular Behcet's disease. Liu X, etal., Invest Ophthalmol Vis Sci. 2013 Sep 5;54(9):6012-7. doi: 10.1167/iovs.13-12159.
31. Changes in intestinal Toll-like receptors and cytokines precede histological injury in a rat model of necrotizing enterocolitis. Liu Y, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Sep;297(3):G442-50. Epub 2009 Jul 16.
32. TLR3 in human eosinophils: functional effects and decreased expression during allergic rhinitis. Mansson A, etal., Int Arch Allergy Immunol. 2010;151(2):118-28. Epub 2009 Sep 15.
33. Toll-like receptor mRNA expression is selectively increased in the colonic mucosa of two animal models relevant to irritable bowel syndrome. McKernan DP, etal., PLoS One. 2009 Dec 9;4(12):e8226.
34. Toll-like receptor 3 upregulation in macrophages participates in the initiation and maintenance of pristane-induced arthritis in rats. Meng L, etal., Arthritis Res Ther. 2010;12(3):R103. Epub 2010 May 25.
35. TLR3 and TLR7 Modulate IgE Production in Antigen Induced Pulmonary Inflammation via Influencing IL-4 Expression in Immune Organs. Meng L, etal., PLoS One. 2011 Feb 25;6(2):e17252.
36. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
37. Association between Toll-Like Receptor 3 (TLR3) rs3775290, TLR7 rs179008, TLR9 rs352140 and Chronic HCV. Mosaad YM, etal., Immunol Invest. 2019 Apr;48(3):321-332. doi: 10.1080/08820139.2018.1527851. Epub 2018 Oct 15.
38. Deleterious role of TLR3 during hyperoxia-induced acute lung injury. Murray LA, etal., Am J Respir Crit Care Med. 2008 Dec 15;178(12):1227-37. Epub 2008 Oct 10.
39. An association study of asthma and total serum immunoglobin E levels for Toll-like receptor polymorphisms in a Japanese population. Noguchi E, etal., Clin Exp Allergy. 2004 Feb;34(2):177-83.
40. The expression and function of Toll-like receptors 3 and 9 in human colon carcinoma. Nojiri K, etal., Oncol Rep. 2013 May;29(5):1737-43. doi: 10.3892/or.2013.2322. Epub 2013 Mar 4.
41. The bacteriostatic protein lipocalin 2 is induced in the central nervous system of mice with west Nile virus encephalitis. Noçon AL, etal., J Virol. 2014 Jan;88(1):679-89. doi: 10.1128/JVI.02094-13. Epub 2013 Oct 30.
42. Toll-like receptor 3 contributes to spinal glial activation and tactile allodynia after nerve injury. Obata K, etal., J Neurochem. 2008 Jun 1;105(6):2249-59.
43. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
44. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
45. Toll-like receptor 3 gene polymorphisms in South African Blacks with type 1 diabetes. Pirie FJ, etal., Tissue Antigens. 2005 Aug;66(2):125-30.
46. Impaired toll-like receptor 3-mediated immune responses from macrophages of patients chronically infected with hepatitis C virus. Qian F, etal., Clin Vaccine Immunol. 2013 Feb;20(2):146-55. doi: 10.1128/CVI.00530-12. Epub 2012 Dec 5.
47. Spinal toll like receptor 3 is involved in chronic pancreatitis-induced mechanical allodynia of rat. Qian NS, etal., Mol Pain. 2011 Feb 22;7(1):15.
48. Effects of single nucleotide polymorphisms on Toll-like receptor 3 activity and expression in cultured cells. Ranjith-Kumar CT, etal., J Biol Chem. 2007 Jun 15;282(24):17696-705. Epub 2007 Apr 13.
49. Toll-like receptor 3 and STAT-1 contribute to double-stranded RNA+ interferon-gamma-induced apoptosis in primary pancreatic beta-cells. Rasschaert J, etal., J Biol Chem. 2005 Oct 7;280(40):33984-91. Epub 2005 Jul 15.
50. Toll-like receptor expression and activation in mice with experimental dry eye. Redfern RL, etal., Invest Ophthalmol Vis Sci. 2013 Feb 28;54(2):1554-63. doi: 10.1167/iovs.12-10739.
51. GOA pipeline RGD automated data pipeline
52. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
53. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
54. Comprehensive gene review and curation RGD comprehensive gene curation
55. Expression of toll-like receptors 2, 4 and 9 is increased in gingival tissue from patients with type 2 diabetes and chronic periodontitis. Rojo-Botello NR, etal., J Periodontal Res. 2012 Feb;47(1):62-73. doi: 10.1111/j.1600-0765.2011.01405.x. Epub 2011 Aug 17.
56. Association of Toll-like receptor 3 polymorphisms with chronic hepatitis B and hepatitis B-related acute-on-chronic liver failure. Rong Y, etal., Inflammation. 2013 Apr;36(2):413-8. doi: 10.1007/s10753-012-9560-4.
57. Deletion of TLR3 alters the pulmonary immune environment and mucus production during respiratory syncytial virus infection. Rudd BD, etal., J Immunol. 2006 Feb 1;176(3):1937-42.
58. Rotavirus double-stranded RNA induces apoptosis and diminishes wound repair in rat intestinal epithelial cells. Sato A, etal., J Gastroenterol Hepatol. 2006 Mar;21(3):521-30.
59. Double-stranded RNA signals antiviral and inflammatory programs and dysfunctional glutamate transport in TLR3-expressing astrocytes. Scumpia PO, etal., Glia. 2005 Nov 1;52(2):153-62.
60. Exosome-mediated activation of toll-like receptor 3 in stellate cells stimulates interleukin-17 production by γδ T cells in liver fibrosis. Seo W, etal., Hepatology. 2016 Aug;64(2):616-31. doi: 10.1002/hep.28644. Epub 2016 Jun 29.
61. Mechanistic investigation of immunosuppression in patients with condyloma acuminata. Shi YJ, etal., Mol Med Rep. 2013 Aug;8(2):480-6. doi: 10.3892/mmr.2013.1511. Epub 2013 Jun 6.
62. Toll-like receptor 3 activation during pregnancy elicits preeclampsia-like symptoms in rats. Tinsley JH, etal., Am J Hypertens. 2009 Dec;22(12):1314-9. Epub 2009 Sep 24.
63. Characterization of innate immune signalling receptors in virus-induced acute asthma. Wood LG, etal., Clin Exp Allergy. 2010 Dec 3. doi: 10.1111/j.1365-2222.2010.03669.x.
64. [Expression of TLR3 and IL-8, Eotaxin in the airway smooth muscle cells induced by PolyI:C]. Yan MH, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2010 Oct;26(10):966-8, 972.
65. Hepatic Toll-Like Receptor 3 expression in chronic hepatitis C genotype 1 correlates with treatment response to peginterferon plus ribavirin. Yuki N, etal., J Viral Hepat. 2010 Feb 1;17(2):130-8. doi: 10.1111/j.1365-2893.2009.01155.x. Epub 2009 Aug 5.
66. Increase in peripheral blood mononuclear cell Toll-like receptor 2/3 expression and reactivity to their ligands in a cohort of patients with wet age-related macular degeneration. Zhu Y, etal., Mol Vis. 2013 Aug 6;19:1826-33. eCollection 2013.
Additional References at PubMed
PMID:12054664   PMID:12855817   PMID:14993594   PMID:15356140   PMID:16111635   PMID:16260493   PMID:16286015   PMID:17008311   PMID:17027917   PMID:17128265   PMID:17897319   PMID:18172197  
PMID:18207576   PMID:18223009   PMID:18250457   PMID:18261938   PMID:18592153   PMID:19047410   PMID:19115402   PMID:19593445   PMID:19734906   PMID:19740627   PMID:20692254   PMID:20848777  
PMID:21266579   PMID:21708001   PMID:21737330   PMID:22647506   PMID:22681877   PMID:22702720   PMID:23155421   PMID:23558035   PMID:23817958   PMID:23965176   PMID:23981041   PMID:24091496  
PMID:24416163   PMID:24423102   PMID:24621600   PMID:24729619   PMID:24914679   PMID:25204797   PMID:25217833   PMID:25533241   PMID:25754930   PMID:25815475   PMID:26062413   PMID:26417991  
PMID:26934179   PMID:28000161   PMID:28726298   PMID:29445737   PMID:32634389   PMID:34015428   PMID:36334783  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81653,554,916 - 53,572,321 (+)NCBIGRCr8
mRatBN7.21646,821,980 - 46,837,900 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1646,822,039 - 46,836,545 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1652,215,759 - 52,229,258 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01655,592,446 - 55,605,923 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01650,855,155 - 50,868,654 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01650,016,466 - 50,031,011 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1650,016,857 - 50,031,214 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01649,739,814 - 49,753,968 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41650,112,910 - 50,126,371 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11650,112,984 - 50,126,440 (+)NCBI
Celera1644,813,138 - 44,826,566 (+)NCBICelera
Cytogenetic Map16q11NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh384186,069,156 - 186,088,073 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4186,068,911 - 186,088,073 (+)EnsemblGRCh38hg38GRCh38
GRCh374186,990,310 - 187,009,227 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364187,227,303 - 187,243,246 (+)NCBINCBI36Build 36hg18NCBI36
Build 344187,365,457 - 187,381,399NCBI
Celera4184,312,848 - 184,328,791 (+)NCBICelera
Cytogenetic Map4q35.1NCBI
HuRef4182,742,451 - 182,758,393 (+)NCBIHuRef
CHM1_14186,966,756 - 186,982,686 (+)NCBICHM1_1
T2T-CHM13v2.04189,409,568 - 189,428,483 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39845,848,702 - 45,864,112 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl845,848,702 - 45,864,117 (-)EnsemblGRCm39 Ensembl
GRCm38845,395,665 - 45,411,075 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl845,395,665 - 45,411,080 (-)EnsemblGRCm38mm10GRCm38
MGSCv37846,481,019 - 46,495,893 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36846,894,482 - 46,909,356 (-)NCBIMGSCv36mm8
Celera848,083,156 - 48,098,074 (-)NCBICelera
Cytogenetic Map8B1.1NCBI
cM Map825.31NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495540322,979,120 - 23,001,467 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540322,977,882 - 23,001,392 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v23183,809,517 - 183,827,550 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14184,159,046 - 184,176,924 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04178,238,352 - 178,256,264 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14190,446,487 - 190,462,728 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4190,446,487 - 190,462,728 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11644,617,012 - 44,633,591 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1644,550,846 - 44,653,247 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1645,103,720 - 45,132,454 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01646,830,974 - 46,859,705 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1646,831,107 - 46,846,486 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11644,798,956 - 44,827,679 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01645,411,963 - 45,440,690 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01645,543,452 - 45,571,950 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494334,721,792 - 34,740,517 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365543,369,469 - 3,385,907 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365543,370,766 - 3,388,125 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1546,969,006 - 46,979,291 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11546,966,262 - 46,977,774 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21553,839,254 - 53,852,671 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.17131,991,068 - 132,014,366 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7131,991,029 - 132,016,232 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037112,309,987 - 112,333,459 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462476916,925,984 - 16,941,196 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476916,925,969 - 16,945,250 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Tlr3
168 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:29
Interacting mature miRNAs:33
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)163195152060148445Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
631833Sach2Saccharin preference QTL 240.01consumption behavior trait (VT:0002069)calculated saccharin drink intake rate (CMO:0001613)164302484250166018Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21646,825,402 - 46,825,624 (+)MAPPERmRatBN7.2
Rnor_6.01650,019,871 - 50,020,090NCBIRnor6.0
Rnor_5.01649,742,828 - 49,743,047UniSTSRnor5.0
RGSC_v3.41650,115,924 - 50,116,143UniSTSRGSC3.4
RGSC_v3.41650,115,923 - 50,116,143RGDRGSC3.4
RGSC_v3.11650,115,998 - 50,116,218RGD
Celera1644,816,145 - 44,816,364UniSTS
RH 3.4 Map16462.8RGD
RH 3.4 Map16462.8UniSTS
RH 2.0 Map16520.1RGD
SHRSP x BN Map1618.13RGD
FHH x ACI Map1623.2999RGD
Cytogenetic Map16q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21646,835,522 - 46,835,740 (+)MAPPERmRatBN7.2
Rnor_6.01650,029,989 - 50,030,206NCBIRnor6.0
Rnor_5.01649,752,946 - 49,753,163UniSTSRnor5.0
RGSC_v3.41650,126,042 - 50,126,259UniSTSRGSC3.4
Celera1644,826,237 - 44,826,454UniSTS
RH 3.4 Map16460.9UniSTS
Cytogenetic Map16q11UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 2 27 17 13 17 28 21 11
Low 1 43 30 24 6 24 8 11 70 7 20 8
Below cutoff 4


RefSeq Acc Id: ENSRNOT00000035781   ⟹   ENSRNOP00000036680
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1646,822,039 - 46,836,545 (+)Ensembl
Rnor_6.0 Ensembl1650,016,857 - 50,030,312 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000087986   ⟹   ENSRNOP00000070415
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1646,824,940 - 46,836,545 (+)Ensembl
Rnor_6.0 Ensembl1650,022,998 - 50,031,214 (+)Ensembl
RefSeq Acc Id: NM_198791   ⟹   NP_942086
Rat AssemblyChrPosition (strand)Source
GRCr81653,554,916 - 53,568,377 (+)NCBI
mRatBN7.21646,822,389 - 46,835,852 (+)NCBI
Rnor_6.01650,016,857 - 50,030,318 (+)NCBI
Rnor_5.01649,739,814 - 49,753,968 (+)NCBI
RGSC_v3.41650,112,910 - 50,126,371 (+)RGD
Celera1644,813,138 - 44,826,566 (+)RGD
RefSeq Acc Id: XM_063275595   ⟹   XP_063131665
Rat AssemblyChrPosition (strand)Source
GRCr81653,555,194 - 53,569,070 (+)NCBI
RefSeq Acc Id: XR_005494652
Rat AssemblyChrPosition (strand)Source
GRCr81653,555,184 - 53,569,070 (+)NCBI
mRatBN7.21646,822,343 - 46,836,545 (+)NCBI
RefSeq Acc Id: XR_010058303
Rat AssemblyChrPosition (strand)Source
GRCr81653,555,184 - 53,572,321 (+)NCBI
Protein Sequences
Protein RefSeqs NP_942086 (Get FASTA)   NCBI Sequence Viewer  
  XP_063131665 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAO62340 (Get FASTA)   NCBI Sequence Viewer  
  BAC81504 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000036680.4
RefSeq Acc Id: NP_942086   ⟸   NM_198791
- Peptide Label: precursor
- UniProtKB: F1LN63 (UniProtKB/TrEMBL),   Q7TNI8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000036680   ⟸   ENSRNOT00000035781
RefSeq Acc Id: ENSRNOP00000070415   ⟸   ENSRNOT00000087986
RefSeq Acc Id: XP_063131665   ⟸   XM_063275595
- Peptide Label: isoform X1
- UniProtKB: Q7TNI8 (UniProtKB/TrEMBL),   F1LN63 (UniProtKB/TrEMBL)
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LN63-F1-model_v2 AlphaFold F1LN63 1-905 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700107
Promoter ID:EPDNEW_R10631
Type:initiation region
Description:toll-like receptor 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01650,016,833 - 50,016,893EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735171 AgrOrtholog
BioCyc Gene G2FUF-11315 BioCyc
Ensembl Genes ENSRNOG00000021726 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000035781.6 UniProtKB/TrEMBL
  ENSRNOT00000087986.2 UniProtKB/TrEMBL
InterPro Cys-rich_flank_reg_C UniProtKB/TrEMBL
  L_dom-like UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  TIR_dom UniProtKB/TrEMBL
  Toll-like_receptor UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/TrEMBL
KEGG Report rno:364594 UniProtKB/TrEMBL
  PTHR24365:SF524 UniProtKB/TrEMBL
Pfam LRR_1 UniProtKB/TrEMBL
  LRR_8 UniProtKB/TrEMBL
  Tlr3_TMD UniProtKB/TrEMBL
PhenoGen Tlr3 PhenoGen
RatGTEx ENSRNOG00000021726 RatGTEx
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  Q80Z88_RAT UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Tlr3  toll-like receptor 3      Symbol and Name status set to approved 1299863 APPROVED