Gene: Tlr3 (toll-like receptor 3) Rattus norvegicus
Analyze
Symbol:
Tlr3
Name:
toll-like receptor 3
RGD ID:
735171
Description:
Exhibits double-stranded RNA binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to exogenous dsRNA; and microglial cell activation. Localizes to cell surface. Used to study asthma. Biomarker of colitis; pancreatitis; perinatal necrotizing enterocolitis; peripheral nervous system disease; and pre-eclampsia. Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; human immunodeficiency virus infectious disease; liver cirrhosis; and type 1 diabetes mellitus. Orthologous to human TLR3 (toll like receptor 3); PARTICIPATES IN Toll-like receptor signaling pathway; hepatitis C pathway; influenza A pathway; INTERACTS WITH (+)-schisandrin B; 2,4-dinitrotoluene; 3-chloropropane-1,2-diol.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
TLR3 (toll like receptor 3) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Tlr3 (toll-like receptor 3) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Tlr3 (toll like receptor 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
TLR3 (toll like receptor 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
TLR3 (toll like receptor 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Tlr3 (toll like receptor 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
TLR3 (toll like receptor 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
TLR3 (toll like receptor 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Tlr3 (toll like receptor 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
TLR3 (toll like receptor 3)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|TreeFam)
Mus musculus (house mouse):
Tlr3 (toll-like receptor 3)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|TreeFam)
Drosophila melanogaster (fruit fly):
conv
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 16 50,016,466 - 50,031,011 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 16 50,016,857 - 50,031,214 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 16 49,739,814 - 49,753,968 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 16 50,112,910 - 50,126,371 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 16 50,112,984 - 50,126,440 (+) NCBI Celera 16 44,813,138 - 44,826,566 (+) NCBI Celera Cytogenetic Map 16 q11 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
RGD Manual Annotations
Acute-On-Chronic Liver Failure susceptibility ISO RGD:1343581 21079425 associated with Hepatitis B, Chronic, DNA:SNP: :1234C>T (human) RGD adult respiratory distress syndrome ISO RGD:1553513 5129134 RGD Alcoholic Liver Diseases treatment ISO RGD:1553513 21079436 ; 21079426 RGD anogenital venereal wart ISO RGD:1343581 40400714 mRNA, protein:increased expression:multiple (human) RGD asthma ISO RGD:1553513 5129475 RGD asthma IMP 5128500 RGD asthma ISO RGD:1343581 5129478 DNA:snp:cds:p.L412F (human) RGD asthma ISO RGD:1343581 5129226 Asthma, Virus-Induced, mRNA:increased expression:sputum (human) RGD asthma no_association ISO RGD:1343581 5129493 DNA:snp:cds:p.L412F (human) RGD autoimmune thyroiditis ISO RGD:1343581 5128798 protein:increased expression:thyroid gland (human) RGD Behcet's disease ISO RGD:1343581 8552883 protein, mRNA:increased expression:peripheral blood mononuclear cell RGD Chronic Hepatitis B susceptibility ISO RGD:1343581 21079416 DNA:snp: :rs3775290(human) RGD Chronic Hepatitis B susceptibility ISO RGD:1343581 21079425 DNA:SNP, haplotype: :1234C>T (human) RGD Chronic Hepatitis C severity ISO RGD:1343581 21079435 RGD Chronic Hepatitis C disease_progression ISO RGD:1343581 21079428 DNA:SNP: :rs3775290(human) RGD Chronic Hepatitis C susceptibility ISO RGD:1343581 21079427 DNA:SNP: :rs3775290(human) RGD Chronic Hepatitis C treatment ISO RGD:1343581 21079423 treatment:peginterferon plus ribavirin. RGD Chronic Hepatitis C treatment ISO RGD:1343581 21079422 DNA:SNP:cds:p.Leu412Phe(human) RGD Chronic Hepatitis C disease_progression ISO RGD:1343581 21079430 DNA:SNP: :rs13126816 (human) RGD Chronic Periodontitis severity ISO RGD:1343581 7794852 protein:increased expression:gingiva: RGD colitis IEP 5128708 mRNA:increased expression:large intestine mucosa (rat) RGD colon carcinoma ISO RGD:1343581 21079438 protein:increased expression:colon RGD dry eye syndrome ISO RGD:1553513 8552916 mRNA more ... RGD Experimental Arthritis IEP 5128706 mRNA, protein:increased expression:spleen (rat) RGD Experimental Arthritis IMP 5128706 RGD Experimental Liver Cirrhosis ISO RGD:1553513 21079415 RGD eye disease ISO RGD:1343581 8552913 mRNA, protein:increased expression:nasal cavity mucosa: RGD hepatitis B susceptibility ISO RGD:1343581 21079431 DNA:SNP, haplotype: rs1879026(human) RGD hepatitis B disease_progression ISO RGD:1343581 21079424 DNA:SNPs, haplotype: rs3775291, rs5743305 (human) RGD hepatitis C ISO RGD:1343581 7175316 associated with glomerulonephritis, mRNA:increased expression:liver: RGD hepatitis C severity ISO RGD:1343581 21079429 associated with liver transplant, DNP:SNP:cds:p.Leu412Phe(human) RGD hepatitis C susceptibility ISO RGD:1343581 21079422 DNA:SNP:cds:p.Leu412Phe(human) RGD hepatitis C disease_progression ISO RGD:1343581 21079437 DNA:SNPs: :rs3775290 more ... RGD hepatocellular carcinoma disease_progression ISO RGD:1343581 21079421 RGD Human Influenza ISO RGD:1553513 5129136 RGD Human Influenza ISO RGD:1553513 5129219 mRNA:increased expression:lung (mouse) RGD Kuhnt-Junius degeneration ISO RGD:1343581 8552827 mRNA:increased expression:peripheral blood mononuclear cell: RGD liver cirrhosis susceptibility ISO RGD:1343581 21079416 DNA:snp: :rs3775290(human) RGD milker's nodule severity ISO RGD:1553513 5129216 RGD mixed connective tissue disease ISO RGD:1553513 5129221 RGD pancreatitis IEP 5128695 protein:increased expression:spinal cord dorsal horn (rat) RGD Papillomavirus Infections resistance ISO RGD:1343581 5129102 mRNA:increased expression:cervix epithelium (human) RGD perinatal necrotizing enterocolitis IEP 5128779 mRNA:increased expression:ileum (rat) RGD peripheral nervous system disease IEP 5129232 protein:increased expression:spinal cord dorsal horn (rat) RGD pre-eclampsia IEP 5128769 protein:increased expression:placenta (rat) RGD Reperfusion Injury IEP 5128693 protein:increased expression:liver (rat) RGD respiratory syncytial virus infectious disease ISO RGD:1553513 5129224 RGD Respiratory Tract Granuloma ISO RGD:1553513 5129133 RGD Seasonal Allergic Rhinitis ISO RGD:1343581 5129130 protein:decreased expression:bone marrow, blood, eosinophil (human) RGD Tobacco Use Disorder ISO RGD:1343581 5129228 mRNA:decreased expression:olfactory epithelial cell (human) RGD type 1 diabetes mellitus ISO RGD:1343581 5129476 DNA:snps:intron:g.2593C>T rs5743313, g.2642C>A rs5743315, g.2690A>G (human) RGD
Imported Annotations - ClinVar
autism spectrum disorder ISO RGD:1343581 8554872 ClinVar Annotator: match by term: Autism spectrum disorders ClinVar PMID:25255310 autistic disorder ISO RGD:1343581 8554872 ClinVar Annotator: match by term: Autistic disorder of childhood onset ClinVar PMID:21681106 , PMID:30208311 Herpes Simplex Encephalitis ISO RGD:1343581 8554872 ClinVar Annotator: match by term: HERPES SIMPLEX ENCEPHALITIS, SUSCEPTIBILITY TO, 2 ClinVar PMID:17872438 more ... Herpes Simplex Encephalitis ISO RGD:1343581 8554872 ClinVar Annotator: match by term: HERPES SIMPLEX ENCEPHALITIS, SUSCEPTIBILITY TO, 2 ClinVar PMID:25339207 Herpes Simplex Encephalitis ISO RGD:1343581 8554872 ClinVar Annotator: match by term: HERPES SIMPLEX ENCEPHALITIS, SUSCEPTIBILITY TO, 2 ClinVar PMID:21911422 more ... Herpes Simplex Encephalitis ISO RGD:1343581 8554872 ClinVar Annotator: match by term: HERPES SIMPLEX ENCEPHALITIS, SUSCEPTIBILITY TO, 2 ClinVar PMID:21911422 Herpes Simplex Encephalitis ISO RGD:1343581 8554872 ClinVar Annotator: match by term: HERPES SIMPLEX ENCEPHALITIS, SUSCEPTIBILITY TO, 2 ClinVar PMID:26513235 , PMID:28492532 Herpes Simplex Encephalitis 1 ISO RGD:1343581 8554872 ClinVar Annotator: match by term: Herpes simplex encephalitis 1 ClinVar PMID:28492532 Herpes Simplex Encephalitis 1 ISO RGD:1343581 8554872 ClinVar Annotator: match by term: HERPES SIMPLEX ENCEPHALITIS, SUSCEPTIBILITY TO, 1 ClinVar PMID:17872438 more ... Herpes Simplex Encephalitis 1 ISO RGD:1343581 8554872 ClinVar Annotator: match by term: Herpes simplex encephalitis 1 ClinVar PMID:25339207 , PMID:28492532 Herpes Simplex Encephalitis 1 ISO RGD:1343581 8554872 ClinVar Annotator: match by term: Herpes simplex encephalitis 1 ClinVar PMID:17434873 more ... Herpes Simplex Encephalitis 1 ISO RGD:1343581 8554872 ClinVar Annotator: match by term: Herpes simplex encephalitis 1 ClinVar PMID:26193622 , PMID:28492532 Herpes Simplex Encephalitis 1 ISO RGD:1343581 8554872 ClinVar Annotator: match by term: HERPES SIMPLEX ENCEPHALITIS, SUSCEPTIBILITY TO, 1 ClinVar PMID:26513235 , PMID:28492532 human immunodeficiency virus infectious disease ISO RGD:1343581 8554872 ClinVar Annotator: match by term: Human immunodeficiency virus type 1, susceptibility to ClinVar PMID:21911422 more ...
Imported Annotations - CTD
Herpes Simplex Encephalitis ISO RGD:1343581 11554173 CTD Direct Evidence: marker/mechanism CTD human immunodeficiency virus infectious disease ISO RGD:1343581 11554173 CTD Direct Evidence: marker/mechanism CTD Imported Annotations - OMIM
Herpes Simplex Encephalitis susceptibility ISO RGD:1343581 7240710 OMIM human immunodeficiency virus infectious disease susceptibility ISO RGD:1343581 7240710 OMIM
(+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of TLR3 mRNA] CTD PMID:31150632 (-)-citrinin decreases expression ISO RGD:1553513 6480464 Citrinin results in decreased expression of TLR3 mRNA CTD PMID:22771370 (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:1343581 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TLR3 mRNA CTD PMID:22079256 1,2-dimethylhydrazine decreases expression ISO RGD:1553513 6480464 1, 2-Dimethylhydrazine results in decreased expression of TLR3 mRNA CTD PMID:22206623 1-nitropyrene multiple interactions ISO RGD:1343581 6480464 [Poly I-C binds to TLR3 protein] which affects the susceptibility to 1-nitropyrene CTD PMID:23458896 17beta-estradiol multiple interactions ISO RGD:1343581 6480464 [Estradiol co-treated with TGFB1 protein] results in decreased expression of TLR3 mRNA CTD PMID:30165855 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of TLR3 mRNA CTD PMID:21346803 3-chloropropane-1,2-diol affects expression EXP 6480464 alpha-Chlorohydrin affects the expression of TLR3 mRNA CTD PMID:28522335 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:1343581 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of TLR3 mRNA more ... CTD PMID:28628672 3-phenylprop-2-enal multiple interactions ISO RGD:1553513 6480464 cinnamic aldehyde inhibits the reaction [Poly I-C results in increased expression of TLR3 mRNA] CTD PMID:18306459 4,4'-diaminodiphenylmethane affects expression ISO RGD:1553513 6480464 4, 4'-diaminodiphenylmethane affects the expression of TLR3 mRNA CTD PMID:18648102 4,4'-sulfonyldiphenol multiple interactions ISO RGD:1343581 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of TLR3 mRNA CTD PMID:28628672 5-fluorouracil increases expression ISO RGD:1343581 6480464 Fluorouracil results in increased expression of TLR3 mRNA CTD PMID:18779317 , PMID:20367642 5-fluorouracil multiple interactions ISO RGD:1343581 6480464 TP53 protein affects the reaction [Fluorouracil results in increased expression of TLR3 mRNA] CTD PMID:18779317 acetamide increases expression EXP 6480464 acetamide results in increased expression of TLR3 mRNA CTD PMID:31881176 acetylsalicylic acid affects response to substance ISO RGD:1343581 6480464 TLR3 polymorphism affects the susceptibility to Aspirin CTD PMID:21461252 aflatoxin B1 affects expression ISO RGD:1343581 6480464 Aflatoxin B1 affects the expression of TLR3 protein CTD PMID:20106945 aflatoxin B1 increases expression ISO RGD:1343581 6480464 Aflatoxin B1 results in increased expression of TLR3 mRNA CTD PMID:22100608 all-trans-retinoic acid increases expression ISO RGD:1343581 6480464 Tretinoin results in increased expression of TLR3 mRNA CTD PMID:23830798 aripiprazole multiple interactions ISO RGD:1343581 6480464 [Aripiprazole co-treated with Ozone] results in decreased expression of TLR3 mRNA CTD PMID:31476115 arsenous acid increases expression ISO RGD:1343581 6480464 Arsenic Trioxide results in increased expression of TLR3 mRNA CTD PMID:20458559 benzo[a]pyrene multiple interactions ISO RGD:1553513 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to TLR3 promoter] CTD PMID:19654925 bis(2-chloroethyl) sulfide increases expression ISO RGD:1553513 6480464 Mustard Gas results in increased expression of TLR3 mRNA CTD PMID:18955075 bisdemethoxycurcumin multiple interactions ISO RGD:1343581 6480464 [bis(4-hydroxycinnamoyl)methane analog co-treated with APP protein] results in increased expression of TLR3 mRNA, [bis(4-hydroxycinnamoyl)methane co-treated with APP protein] results in increased expression of TLR3 mRNA CTD PMID:22029407 bisphenol A increases methylation ISO RGD:1343581 6480464 bisphenol A results in increased methylation of TLR3 gene CTD PMID:22576693 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of TLR3 mRNA CTD PMID:30816183 bisphenol A multiple interactions ISO RGD:1343581 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TLR3 mRNA CTD PMID:28628672 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of TLR3 mRNA CTD PMID:25181051 bisphenol A decreases expression ISO RGD:1343581 6480464 bisphenol A results in decreased expression of TLR3 mRNA CTD PMID:22576693 bisphenol F multiple interactions ISO RGD:1343581 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TLR3 mRNA CTD PMID:28628672 cadmium dichloride decreases methylation EXP 6480464 Cadmium Chloride results in decreased methylation of TLR3 promoter CTD PMID:22457795 cadmium selenide multiple interactions ISO RGD:1343581 6480464 [cadmium selenide co-treated with zinc sulfide] results in increased expression of TLR3 mRNA CTD PMID:22342292 calcitriol increases expression ISO RGD:1343581 6480464 Calcitriol results in increased expression of TLR3 mRNA CTD PMID:19918113 , PMID:21592394 calcitriol multiple interactions ISO RGD:1343581 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of TLR3 mRNA CTD PMID:21592394 carbon nanotube multiple interactions ISO RGD:1343581 6480464 [[Poly I-C binds to and results in increased activity of TLR3 protein] which co-treated with Nanotubes, Carbon] results in increased secretion of IL12B protein, [[Poly I-C binds to and results in increased activity of TLR3 protein] which co-treated with Nanotubes, Carbon] results in increased secretion of TNF protein CTD PMID:23266719 carbon nanotube increases expression ISO RGD:1553513 6480464 Nanotubes, Carbon results in increased expression of TLR3 mRNA CTD PMID:25554681 chlorogenic acid multiple interactions ISO RGD:1553513 6480464 Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of TLR3 protein] CTD PMID:26079055 chloroquine multiple interactions ISO RGD:1343581 6480464 Chloroquine inhibits the reaction [Poly I-C results in increased activity of TLR3 protein] CTD PMID:21398612 chromium(6+) decreases expression ISO RGD:1343581 6480464 chromium hexavalent ion results in decreased expression of TLR3 mRNA CTD PMID:30690063 cisplatin increases expression ISO RGD:1553513 6480464 Cisplatin results in increased expression of TLR3 mRNA CTD PMID:21151649 , PMID:26546572 cisplatin multiple interactions ISO RGD:1343581 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of TLR3 mRNA CTD PMID:27392435 cisplatin increases expression ISO RGD:1343581 6480464 Cisplatin results in increased expression of TLR3 mRNA CTD PMID:27392435 cyanidin cation multiple interactions EXP 6480464 cyanidin inhibits the reaction [Freund's Adjuvant results in increased expression of TLR3 protein] CTD PMID:32044269 cyanidin cation multiple interactions ISO RGD:1553513 6480464 cyanidin inhibits the reaction [[IL17A protein co-treated with Freund's Adjuvant] results in increased expression of TLR3 protein], cyanidin inhibits the reaction [IL17A protein promotes the reaction [Freund's Adjuvant results in increased expression of TLR3 protein]] CTD PMID:32044269 cyclosporin A increases expression ISO RGD:1343581 6480464 Cyclosporine results in increased expression of TLR3 mRNA CTD PMID:20106945 more ... deoxynivalenol decreases expression ISO RGD:1553513 6480464 deoxynivalenol results in decreased expression of TLR3 mRNA CTD PMID:22968694 dexamethasone decreases expression ISO RGD:1343581 6480464 Dexamethasone results in decreased expression of TLR3 mRNA CTD PMID:12732289 dexamethasone multiple interactions ISO RGD:1343581 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of TLR3 mRNA more ... CTD PMID:28628672 diarsenic trioxide increases expression ISO RGD:1343581 6480464 Arsenic Trioxide results in increased expression of TLR3 mRNA CTD PMID:20458559 dorsomorphin multiple interactions ISO RGD:1343581 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin decreases expression ISO RGD:1343581 6480464 Doxorubicin results in decreased expression of TLR3 mRNA, Doxorubicin results in decreased expression of TLR3 protein CTD PMID:29803840 , PMID:29959987 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of TLR3 mRNA CTD PMID:29391264 ethanol increases expression ISO RGD:1553513 6480464 Ethanol results in increased expression of TLR3 mRNA CTD PMID:30319688 ethanol affects expression ISO RGD:1553513 6480464 Ethanol affects the expression of TLR3 mRNA CTD PMID:30319688 folic acid decreases expression ISO RGD:1343581 6480464 Folic Acid results in decreased expression of TLR3 mRNA CTD PMID:28752528 GW 4064 multiple interactions ISO RGD:1553513 6480464 GW 4064 promotes the reaction [NR1H4 protein binds to TLR3 gene] CTD PMID:20091679 hydroquinone decreases expression ISO RGD:1343581 6480464 hydroquinone results in decreased expression of TLR3 mRNA CTD PMID:31256213 indole-3-methanol affects expression EXP 6480464 indole-3-carbinol affects the expression of TLR3 mRNA CTD PMID:21396975 indometacin multiple interactions ISO RGD:1343581 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of TLR3 mRNA more ... CTD PMID:28628672 lipopolysaccharide increases expression ISO RGD:1343581 6480464 Lipopolysaccharides results in increased expression of TLR3 mRNA CTD PMID:15191912 lipopolysaccharide increases expression ISO RGD:1553513 6480464 Lipopolysaccharides results in increased expression of TLR3 mRNA CTD PMID:24056979 , PMID:25843059 lipopolysaccharide multiple interactions ISO RGD:1553513 6480464 3 more ... CTD PMID:24056979 , PMID:25843059 metam multiple interactions ISO RGD:1553513 6480464 methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of TLR3 mRNA] CTD PMID:24056979 metformin multiple interactions ISO RGD:1343581 6480464 [Paclitaxel co-treated with Metformin] results in increased expression of TLR3 mRNA CTD PMID:29309887 methotrexate increases expression ISO RGD:1343581 6480464 Methotrexate results in increased expression of TLR3 mRNA CTD PMID:21678067 methotrexate multiple interactions EXP 6480464 Methotrexate inhibits the reaction [pristane results in increased expression of TLR3 mRNA] CTD PMID:24423102 nickel sulfate increases expression ISO RGD:1343581 6480464 nickel sulfate results in increased expression of TLR3 mRNA CTD PMID:22714537 nitrates increases expression EXP 6480464 Nitrates results in increased expression of TLR3 mRNA CTD PMID:30022042 o-anisidine decreases expression ISO RGD:1343581 6480464 2-anisidine results in decreased expression of TLR3 mRNA CTD PMID:28089782 ozone decreases expression ISO RGD:1343581 6480464 Ozone results in decreased expression of TLR3 mRNA CTD PMID:31476115 ozone multiple interactions ISO RGD:1343581 6480464 [Aripiprazole co-treated with Ozone] results in decreased expression of TLR3 mRNA CTD PMID:31476115 paclitaxel multiple interactions ISO RGD:1343581 6480464 [Paclitaxel co-treated with Metformin] results in increased expression of TLR3 mRNA CTD PMID:29309887 paracetamol decreases expression ISO RGD:1343581 6480464 Acetaminophen results in decreased expression of TLR3 mRNA CTD PMID:21420995 more ... paracetamol multiple interactions ISO RGD:1553513 6480464 Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of TLR3 protein] CTD PMID:26079055 paracetamol increases expression ISO RGD:1553513 6480464 Acetaminophen results in increased expression of TLR3 protein CTD PMID:26079055 pentachlorophenol increases expression ISO RGD:1553513 6480464 Pentachlorophenol results in increased expression of TLR3 mRNA CTD PMID:23892564 perfluorononanoic acid increases expression ISO RGD:1343581 6480464 perfluorononanoic acid results in increased expression of TLR3 mRNA CTD PMID:32588087 perfluorooctanoic acid decreases expression ISO RGD:1343581 6480464 perfluorooctanoic acid results in decreased expression of TLR3 mRNA CTD PMID:32219433 phenylmercury acetate multiple interactions ISO RGD:1343581 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TLR3 mRNA CTD PMID:27188386 pirinixic acid decreases expression ISO RGD:1553513 6480464 pirinixic acid results in decreased expression of TLR3 mRNA CTD PMID:20813756 poly(I:C) increases expression ISO RGD:1343581 6480464 Poly I-C results in increased expression of TLR3 mRNA CTD PMID:17669408 , PMID:21418039 poly(I:C) increases activity ISO RGD:1553513 6480464 Poly I-C results in increased activity of TLR3 protein CTD PMID:25780039 poly(I:C) multiple interactions EXP 6480464 MIR26A mRNA inhibits the reaction [Poly I-C results in increased activity of TLR3 protein] CTD PMID:24423102 poly(I:C) increases activity EXP 6480464 Poly I-C results in increased activity of TLR3 protein CTD PMID:24423102 poly(I:C) increases activity ISO RGD:1343581 6480464 Poly I-C results in increased activity of TLR3 protein CTD PMID:21398612 more ... poly(I:C) increases expression ISO RGD:1553513 6480464 Poly I-C results in increased expression of TLR3 mRNA CTD PMID:18306459 poly(I:C) multiple interactions ISO RGD:1553513 6480464 cinnamic aldehyde inhibits the reaction [Poly I-C results in increased expression of TLR3 mRNA] CTD PMID:18306459 poly(I:C) multiple interactions ISO RGD:1343581 6480464 [[Poly I-C binds to and results in increased activity of TLR3 protein] which co-treated with Nanotubes, Carbon] results in increased secretion of IL12B protein more ... CTD PMID:16399790 more ... potassium chromate multiple interactions ISO RGD:1343581 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TLR3 mRNA CTD PMID:22079256 potassium chromate decreases expression ISO RGD:1343581 6480464 potassium chromate(VI) results in decreased expression of TLR3 mRNA CTD PMID:22079256 , PMID:22714537 pregnenolone 16alpha-carbonitrile decreases expression ISO RGD:1553513 6480464 Pregnenolone Carbonitrile results in decreased expression of TLR3 mRNA CTD PMID:28903501 pristane multiple interactions EXP 6480464 Methotrexate inhibits the reaction [pristane results in increased expression of TLR3 mRNA] more ... CTD PMID:24423102 pristane increases expression EXP 6480464 pristane results in increased expression of TLR3 mRNA, pristane results in increased expression of TLR3 protein CTD PMID:24423102 pyrene multiple interactions ISO RGD:1343581 6480464 [Poly I-C binds to TLR3 protein] which affects the susceptibility to pyrene CTD PMID:23458896 quinacrine multiple interactions ISO RGD:1343581 6480464 Quinacrine inhibits the reaction [Poly I-C results in increased activity of TLR3 protein] CTD PMID:21398612 resveratrol decreases expression ISO RGD:1553513 6480464 resveratrol results in decreased expression of TLR3 mRNA CTD PMID:21937650 SB 431542 multiple interactions ISO RGD:1343581 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 serpentine asbestos increases expression ISO RGD:1343581 6480464 Asbestos, Serpentine results in increased expression of TLR3 mRNA CTD PMID:24160326 silicon dioxide decreases expression ISO RGD:1343581 6480464 Silicon Dioxide analog results in decreased expression of TLR3 mRNA CTD PMID:25895662 silver atom decreases expression ISO RGD:1343581 6480464 Silver results in decreased expression of TLR3 mRNA CTD PMID:22342292 silver atom decreases expression ISO RGD:1553513 6480464 Silver results in decreased expression of TLR3 mRNA CTD PMID:27131904 silver atom increases expression ISO RGD:1343581 6480464 Silver analog results in increased expression of TLR3 mRNA CTD PMID:24462830 silver(0) decreases expression ISO RGD:1343581 6480464 Silver results in decreased expression of TLR3 mRNA CTD PMID:22342292 silver(0) decreases expression ISO RGD:1553513 6480464 Silver results in decreased expression of TLR3 mRNA CTD PMID:27131904 silver(0) increases expression ISO RGD:1343581 6480464 Silver analog results in increased expression of TLR3 mRNA CTD PMID:24462830 sodium arsenite increases expression ISO RGD:1343581 6480464 sodium arsenite results in increased expression of TLR3 mRNA CTD PMID:17879257 sodium arsenite decreases expression ISO RGD:1343581 6480464 sodium arsenite results in decreased expression of TLR3 mRNA CTD PMID:28595984 sodium aurothiosulfate multiple interactions ISO RGD:1343581 6480464 TLR3 protein affects the reaction [Gold Sodium Thiosulfate results in increased secretion of CXCL8 protein] CTD PMID:25458486 streptozocin multiple interactions ISO RGD:1343581 6480464 TNF protein inhibits the reaction [Streptozocin results in increased expression of TLR3 mRNA] CTD PMID:20446767 streptozocin increases expression ISO RGD:1553513 6480464 Streptozocin results in increased expression of TLR3 mRNA CTD PMID:20446767 testosterone multiple interactions ISO RGD:1343581 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of TLR3 mRNA CTD PMID:21592394 testosterone increases expression ISO RGD:1343581 6480464 Testosterone results in increased expression of TLR3 mRNA CTD PMID:21592394 testosterone enanthate affects expression ISO RGD:1343581 6480464 testosterone enanthate affects the expression of TLR3 mRNA CTD PMID:17440010 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of TLR3 mRNA CTD PMID:31150632 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of TLR3 mRNA] CTD PMID:31150632 titanium dioxide increases expression ISO RGD:1343581 6480464 titanium dioxide results in increased expression of TLR3 mRNA CTD PMID:22342292 triclosan increases expression ISO RGD:1343581 6480464 Triclosan results in increased expression of TLR3 mRNA CTD PMID:30510588 trimellitic anhydride decreases expression ISO RGD:1553513 6480464 trimellitic anhydride results in decreased expression of TLR3 mRNA CTD PMID:19042947 tris(2-butoxyethyl) phosphate affects expression ISO RGD:1343581 6480464 tris(2-butoxyethyl) phosphate affects the expression of TLR3 mRNA CTD PMID:29024780 valproic acid decreases expression ISO RGD:1343581 6480464 Valproic Acid results in decreased expression of TLR3 mRNA CTD PMID:29154799 valproic acid multiple interactions ISO RGD:1343581 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TLR3 mRNA CTD PMID:27188386 valproic acid increases expression ISO RGD:1343581 6480464 Valproic Acid results in increased expression of TLR3 mRNA CTD PMID:24383497 more ... vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of TLR3 mRNA CTD PMID:18629315 zearalenone increases expression ISO RGD:1343581 6480464 Zearalenone results in increased expression of TLR3 mRNA CTD PMID:27757495
Biological Process cellular response to drug IEP 5128798 methimazole derivative C10 RGD cellular response to exogenous dsRNA IEP 5128701 RGD cellular response to exogenous dsRNA IMP 2301737 RGD cellular response to interferon-beta IEP 5128798 RGD cellular response to interferon-gamma IEP 5128794 intestinal epithelial cells RGD cellular response to interferon-gamma NOT IEP 5128798 thyrocytes RGD cellular response to mechanical stimulus ISO RGD:1343581 1624291 (PMID:19593445) RGD PMID:19593445 defense response ISO RGD:1553513 1624291 MGI:2653138 (MGI:2151955 , PMID:11607032) RGD MGI:2151955 , PMID:11607032 defense response to virus ISO RGD:1553513 1624291 MGI:2429859 (MGI:3774908 , PMID:18250457) RGD MGI:3774908 , PMID:18250457 extrinsic apoptotic signaling pathway ISO RGD:1343581 1624291 (PMID:21737330) RGD PMID:21737330 I-kappaB phosphorylation ISO RGD:1343581 1624291 (PMID:19740627) RGD PMID:19740627 inflammatory response IBA PANTHER:PTN000687652 more ... 13792537 PMID:21873635 GO_Central male gonad development IEP 5129498 epididymus RGD microglial cell activation IDA 1643119 RGD MyD88-independent toll-like receptor signaling pathway IEA InterPro:IPR027173 1600115 GO_REF:0000002 InterPro GO_REF:0000002 necroptotic signaling pathway ISO RGD:1343581 1624291 (PMID:21737330) RGD PMID:21737330 positive regulation of angiogenesis ISO RGD:1553513 1624291 RNAcentral:URS00001F1DA8_10090 (MGI:5766647, PMID:26934179) RGD MGI:5766647 , PMID:26934179 positive regulation of apoptotic process IEP 5128770 RGD positive regulation of chemokine production ISO RGD:1343581 1624291 (PMID:19740627) RGD PMID:19740627 positive regulation of chemokine production ISO RGD:1553513 1624291 MGI:3690535 (MGI:2669022 , PMID:12855817) RGD MGI:2669022 , PMID:12855817 positive regulation of gene expression ISO RGD:1343581 1624291 (PMID:23817958), (PMID:25754930) RGD PMID:23817958 , PMID:25754930 positive regulation of I-kappaB kinase/NF-kappaB signaling ISO RGD:1553513 1624291 MGI:1346877 more ... RGD MGI:2669022 more ... positive regulation of inflammatory response IEA InterPro:IPR027173 1600115 GO_REF:0000002 InterPro GO_REF:0000002 positive regulation of interferon-alpha production ISO RGD:1343581 1624291 (PMID:16286015) RGD PMID:16286015 positive regulation of interferon-beta production ISO RGD:1343581 1624291 (PMID:12054664), (PMID:16286015) RGD PMID:12054664 , PMID:16286015 positive regulation of interferon-beta production ISO RGD:1553513 1624291 (MGI:4456948, PMID:15356140) RGD MGI:4456948 , PMID:15356140 positive regulation of interferon-gamma production ISO RGD:1343581 1624291 (PMID:16286015) RGD PMID:16286015 positive regulation of interleukin-12 production ISO RGD:1553513 1624291 (MGI:4456948, PMID:15356140) RGD MGI:4456948 , PMID:15356140 positive regulation of interleukin-6 production ISO RGD:1343581 1624291 (PMID:19740627) RGD PMID:19740627 positive regulation of interleukin-6 production ISO RGD:1553513 1624291 MGI:2653138 (MGI:3697006 more ... RGD MGI:3697006 more ... positive regulation of interleukin-8 production ISO RGD:1343581 1624291 (PMID:17128265) RGD PMID:17128265 positive regulation of JNK cascade ISO RGD:1553513 1624291 (MGI:3607973, PMID:16260493) RGD MGI:3607973 , PMID:16260493 positive regulation of NF-kappaB transcription factor activity ISO RGD:1553513 1624291 MGI:3690535 (MGI:2669022 , PMID:12855817) RGD MGI:2669022 , PMID:12855817 positive regulation of NIK/NF-kappaB signaling ISO RGD:1343581 1624291 (PMID:19740627) RGD PMID:19740627 positive regulation of toll-like receptor signaling pathway ISO RGD:1343581 1624291 (PMID:17128265) RGD PMID:17128265 positive regulation of transcription by RNA polymerase II ISO RGD:1553513 1624291 (MGI:4456948, PMID:15356140) RGD MGI:4456948 , PMID:15356140 positive regulation of tumor necrosis factor production ISO RGD:1553513 1624291 MGI:2653138 (MGI:3697006 more ... RGD MGI:3697006 more ... positive regulation of type I interferon production ISO RGD:1553513 1624291 (MGI:3774796, PMID:18207576) RGD MGI:3774796 , PMID:18207576 positive regulation of type III interferon production ISO RGD:1553513 1624291 (MGI:3774796, PMID:18207576) RGD MGI:3774796 , PMID:18207576 regulation of dendritic cell cytokine production ISO RGD:1553513 1624291 (MGI:3828894, PMID:19047410) RGD MGI:3828894 , PMID:19047410 response to dsRNA IDA 1643119 poly(I:C) - a synthetic analog of double-stranded RNA, a molecular pattern associated with viral infection RGD response to exogenous dsRNA ISO RGD:1343581 1624291 (PMID:21266579) RGD PMID:21266579 response to exogenous dsRNA ISO RGD:1553513 1624291 MGI:3690535 (MGI:2669022 , PMID:12855817) RGD MGI:2669022 , PMID:12855817 response to virus IEP 5128798 RGD response to virus ISO RGD:1553513 1624291 MGI:2653138 (MGI:3037412 , PMID:14993594) RGD MGI:3037412 , PMID:14993594 toll-like receptor 3 signaling pathway IEA InterPro:IPR027173 1600115 GO_REF:0000002 InterPro GO_REF:0000002 toll-like receptor signaling pathway IDA 1643119 RGD toll-like receptor signaling pathway IBA MGI:MGI:1341296 more ... 13792537 PMID:21873635 GO_Central Cellular Component cell surface NOT ISO RGD:1343581 1624291 (PMID:19740627) RGD PMID:19740627 cell surface IDA 5128706 RGD cytoplasm ISO RGD:1343581 1624291 (PMID:19740627) RGD PMID:19740627 integral component of plasma membrane IBA FB:FBgn0262473 more ... 13792537 PMID:21873635 GO_Central intracellular anatomical structure IDA 5128706 RGD Molecular Function double-stranded RNA binding IDA 1643119 poly(I:C) - a synthetic analog of double-stranded RNA, a molecular pattern associated with viral infection RGD double-stranded RNA binding ISO RGD:1343581 1624291 (PMID:16111635) RGD PMID:16111635 identical protein binding ISO RGD:1343581 1624291 UniProtKB:O15455 (PMID:18172197), (PMID:23155421), (PMID:25217833) RGD PMID:18172197 more ... protein binding ISO RGD:1343581 1624291 UniProtKB:P27986 more ... RGD PMID:16858407 , PMID:25736436 protein binding ISO RGD:1553513 1624291 UniProtKB:E9Q4P1 more ... RGD MGI:4457250 more ... signaling receptor activity IBA FB:FBgn0026760 more ... 13792537 PMID:21873635 GO_Central transmembrane signaling receptor activity IEA InterPro:IPR017241 , InterPro:IPR027173 1600115 GO_REF:0000002 InterPro GO_REF:0000002
Gene-Chemical Interaction Annotations
