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Gene: Dgat2 (diacylglycerol O-acyltransferase 2) Rattus norvegicus
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Symbol: Dgat2
Name: diacylglycerol O-acyltransferase 2
RGD ID: 620329
Description: Exhibits diacylglycerol O-acyltransferase activity. Involved in several processes, including diacylglycerol metabolic process; positive regulation of gluconeogenesis; and regulation of lipid metabolic process. Localizes to intracellular membrane-bounded organelle. Predicted to colocalize with mitochondrion. Used to study fatty liver disease. Biomarker of chronic kidney disease; non-alcoholic fatty liver disease; and premature menopause. Human ortholog(s) of this gene implicated in non-alcoholic fatty liver disease. Orthologous to human DGAT2 (diacylglycerol O-acyltransferase 2); PARTICIPATES IN bile acid signaling pathway; glycerolipid metabolic pathway; INTERACTS WITH (+)-schisandrin B; (R)-lipoic acid; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: acyl-CoA retinol O-fatty-acyltransferase; ARAT; diacylglycerol O-acyltransferase homolog 2 (mouse); diglyceride acyltransferase 2; MGC108863; retinol O-fatty-acyltransferase
Orthologs:
Homo sapiens (human) : DGAT2 (diacylglycerol O-acyltransferase 2)  HGNC  Alliance
Mus musculus (house mouse) : Dgat2 (diacylglycerol O-acyltransferase 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dgat2 (diacylglycerol O-acyltransferase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : DGAT2 (diacylglycerol O-acyltransferase 2)
Canis lupus familiaris (dog) : DGAT2 (diacylglycerol O-acyltransferase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dgat2 (diacylglycerol O-acyltransferase 2)
Sus scrofa (pig) : DGAT2 (diacylglycerol O-acyltransferase 2)
Chlorocebus sabaeus (African green monkey) : DGAT2 (diacylglycerol O-acyltransferase 2)
Heterocephalus glaber (naked mole-rat) : Dgat2 (diacylglycerol O-acyltransferase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01164,113,459 - 164,143,818 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1164,113,459 - 164,143,818 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01170,316,041 - 170,346,352 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41156,447,588 - 156,478,740 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11156,529,080 - 156,531,888 (-)NCBI
Celera1151,539,454 - 151,569,146 (-)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Dgat2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620329
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.