Dgat2 (diacylglycerol O-acyltransferase 2) - Rat Genome Database

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Gene: Dgat2 (diacylglycerol O-acyltransferase 2) Rattus norvegicus
Analyze
Symbol: Dgat2
Name: diacylglycerol O-acyltransferase 2
RGD ID: 620329
Description: Enables diacylglycerol O-acyltransferase activity. Involved in several processes, including bile acid signaling pathway; positive regulation of gluconeogenesis; and regulation of lipid metabolic process. Predicted to be located in cytosol; lipid droplet; and perinuclear endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum membrane. Predicted to colocalize with mitochondrion. Used to study fatty liver disease. Biomarker of chronic kidney disease; non-alcoholic fatty liver disease; and premature menopause. Human ortholog(s) of this gene implicated in non-alcoholic fatty liver disease. Orthologous to human DGAT2 (diacylglycerol O-acyltransferase 2); PARTICIPATES IN bile acid signaling pathway; glycerolipid metabolic pathway; INTERACTS WITH (+)-schisandrin B; (R)-lipoic acid; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: acyl-CoA retinol O-fatty-acyltransferase; ARAT; diacylglycerol O-acyltransferase homolog 2 (mouse); diglyceride acyltransferase 2; MGC108863; retinol O-fatty-acyltransferase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21153,454,078 - 153,484,432 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1153,454,080 - 153,484,428 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1161,450,259 - 161,480,647 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01168,630,412 - 168,660,798 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01161,503,932 - 161,534,315 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01164,113,459 - 164,143,818 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1164,113,459 - 164,143,818 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01170,316,041 - 170,346,352 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41156,447,588 - 156,478,740 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11156,529,080 - 156,531,888 (-)NCBI
Celera1151,539,454 - 151,569,146 (-)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-(2-chloroethyl)-4-methylthiazole  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzylpenicillin  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbamazepine  (EXP)
carbendazim  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorothalonil  (ISO)
chlorpyrifos  (EXP)
cholesterol  (ISO)
choline  (ISO)
chrysene  (ISO)
clofibrate  (EXP,ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP,ISO)
Diallyl sulfide  (ISO)
dieldrin  (ISO)
difenoconazole  (ISO)
dioscin  (EXP,ISO)
diquat  (ISO)
diuron  (EXP)
dorsomorphin  (EXP)
endosulfan  (EXP,ISO)
epoxiconazole  (ISO)
erythromycin A  (ISO)
ethanol  (EXP,ISO)
farnesol  (ISO)
fenthion  (ISO)
flutamide  (EXP)
fructose  (ISO)
genistein  (ISO)
gentamycin  (EXP)
graphite  (ISO)
GW 4064  (ISO)
GW 7647  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
iron dichloride  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
lipoic acid  (EXP)
mangiferin  (EXP)
menadione  (ISO)
metformin  (ISO)
methamphetamine  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nicotinic acid  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
nordihydroguaiaretic acid  (EXP)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
oleic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium cyanide  (ISO)
potassium dichromate  (ISO)
procymidone  (ISO)
propamocarb  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
rebaudioside A  (ISO)
rifaximin  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP)
sucrose  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
tamoxifen  (ISO)
tectoridin  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP)
tetracycline  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
thymol  (ISO)
thymol sulfate(1-)  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triadimefon  (EXP)
tributyl phosphate  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
Tris(2,3-dibromopropyl) phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
trovafloxacin  (EXP,ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vanillic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance. Choi CS, etal., J Biol Chem. 2007 Aug 3;282(31):22678-88. Epub 2007 May 27.
2. Impaired VLDL assembly: a novel mechanism contributing to hepatic lipid accumulation following ovariectomy and high-fat/high-cholesterol diets? Côté I, etal., Br J Nutr. 2014 Nov 28;112(10):1592-600. doi: 10.1017/S0007114514002517. Epub 2014 Sep 29.
3. Microarray analysis of the infrapatellar fat pad in knee osteoarthritis: relationship with joint inflammation. Gandhi R, etal., J Rheumatol. 2011 Sep;38(9):1966-72. Epub 2011 Jul 15.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Dysregulation of hepatic fatty acid metabolism in chronic kidney disease. Jin K, etal., Nephrol Dial Transplant. 2013 Feb;28(2):313-20. doi: 10.1093/ndt/gfs350. Epub 2012 Oct 8.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Monetti M, etal., Cell Metab. 2007 Jul;6(1):69-78.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Clostridium butyricum MIYAIRI 588 improves high-fat diet-induced non-alcoholic fatty liver disease in rats. Seo M, etal., Dig Dis Sci. 2013 Dec;58(12):3534-44. doi: 10.1007/s10620-013-2879-3. Epub 2013 Oct 29.
15. Distinct ontogenic patterns of overt and latent DGAT activities of rat liver microsomes. Waterman IJ, etal., J Lipid Res 2002 Sep;43(9):1555-62.
16. Effect of Creosote Bush-Derived NDGA on Expression of Genes Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats: Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic Steatosis. Zhang H, etal., PLoS One. 2015 Sep 22;10(9):e0138203. doi: 10.1371/journal.pone.0138203. eCollection 2015.
Additional References at PubMed
PMID:11481335   PMID:12077311   PMID:12477932   PMID:14521909   PMID:14668353   PMID:15489334   PMID:18175806   PMID:18252207   PMID:18696335   PMID:19049983   PMID:21317108   PMID:21680734  
PMID:24953780   PMID:25164810   PMID:27184406   PMID:28420705  


Genomics

Comparative Map Data
Dgat2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21153,454,078 - 153,484,432 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1153,454,080 - 153,484,428 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1161,450,259 - 161,480,647 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01168,630,412 - 168,660,798 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01161,503,932 - 161,534,315 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01164,113,459 - 164,143,818 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1164,113,459 - 164,143,818 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01170,316,041 - 170,346,352 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41156,447,588 - 156,478,740 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11156,529,080 - 156,531,888 (-)NCBI
Celera1151,539,454 - 151,569,146 (-)NCBICelera
Cytogenetic Map1q32NCBI
DGAT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381175,768,778 - 75,801,534 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1175,759,512 - 75,801,535 (+)EnsemblGRCh38hg38GRCh38
GRCh371175,479,823 - 75,512,579 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361175,157,456 - 75,190,225 (+)NCBINCBI36Build 36hg18NCBI36
Build 341175,157,455 - 75,190,225NCBI
Celera1172,787,576 - 72,820,377 (+)NCBICelera
Cytogenetic Map11q13.5NCBI
HuRef1171,776,445 - 71,809,321 (+)NCBIHuRef
CHM1_11175,363,395 - 75,396,193 (+)NCBICHM1_1
T2T-CHM13v2.01175,698,501 - 75,731,257 (+)NCBIT2T-CHM13v2.0
Dgat2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39798,802,870 - 98,831,920 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl798,802,865 - 98,831,926 (-)EnsemblGRCm39 Ensembl
GRCm38799,153,663 - 99,182,713 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl799,153,658 - 99,182,719 (-)EnsemblGRCm38mm10GRCm38
MGSCv377106,302,173 - 106,331,223 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36799,028,855 - 99,057,905 (-)NCBIMGSCv36mm8
Celera799,478,097 - 99,506,939 (-)NCBICelera
Cytogenetic Map7E1NCBI
cM Map754.01NCBI
Dgat2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541416,059,781 - 16,089,727 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541416,059,781 - 16,089,727 (-)NCBIChiLan1.0ChiLan1.0
DGAT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11177,738,170 - 77,770,948 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01170,824,791 - 70,857,530 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11174,109,523 - 74,158,854 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1174,126,169 - 74,158,854 (+)Ensemblpanpan1.1panPan2
DGAT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12122,833,659 - 22,850,300 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2122,834,518 - 22,851,260 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2122,599,527 - 22,636,714 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02123,036,854 - 23,073,838 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2123,036,854 - 23,069,245 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12122,835,850 - 22,868,136 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02123,032,018 - 23,064,319 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02122,949,639 - 22,986,269 (-)NCBIUU_Cfam_GSD_1.0
Dgat2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494762,914,608 - 62,944,920 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364984,514,184 - 4,544,527 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049364984,514,212 - 4,544,523 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DGAT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl910,032,128 - 10,068,437 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1910,032,163 - 10,066,082 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2911,160,734 - 11,176,926 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DGAT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,985,413 - 67,018,058 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl166,985,466 - 67,021,182 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604358,785,359 - 58,818,019 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dgat2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248171,386,764 - 1,418,300 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248171,386,876 - 1,418,129 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dgat2
117 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:358
Count of miRNA genes:222
Interacting mature miRNAs:255
Transcripts:ENSRNOT00000022557
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1131763437159756369Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1136745990163747690Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1144267916172949660Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144267916174133260Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat

Markers in Region
RH134485  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21153,454,184 - 153,454,370 (+)MAPPERmRatBN7.2
Rnor_6.01164,113,564 - 164,113,749NCBIRnor6.0
Rnor_5.01170,316,146 - 170,316,331UniSTSRnor5.0
RGSC_v3.41156,447,693 - 156,447,878UniSTSRGSC3.4
Celera1151,539,559 - 151,539,744UniSTS
RH 3.4 Map11232.7UniSTS
Cytogenetic Map1q32UniSTS
RH139205  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21153,458,492 - 153,459,149 (+)MAPPERmRatBN7.2
Rnor_6.01164,117,900 - 164,118,556NCBIRnor6.0
Rnor_5.01170,320,388 - 170,321,044UniSTSRnor5.0
RGSC_v3.41156,452,822 - 156,453,478UniSTSRGSC3.4
Celera1151,543,235 - 151,543,891UniSTS
RH 3.4 Map11233.6UniSTS
Cytogenetic Map1q32UniSTS
G42985  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21153,454,906 - 153,455,054 (+)MAPPERmRatBN7.2
Rnor_6.01164,114,286 - 164,114,433NCBIRnor6.0
Rnor_5.01170,316,868 - 170,317,015UniSTSRnor5.0
RGSC_v3.41156,448,415 - 156,448,562UniSTSRGSC3.4
Celera1151,540,281 - 151,540,428UniSTS
Cytogenetic Map1q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 10 57 41 11 41 8 11 41 29 28 11 8
Low 33 8 33 6 13
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000022557   ⟹   ENSRNOP00000022557
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1153,454,080 - 153,484,428 (-)Ensembl
Rnor_6.0 Ensembl1164,113,459 - 164,143,818 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000081669   ⟹   ENSRNOP00000069294
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1153,454,080 - 153,482,804 (-)Ensembl
Rnor_6.0 Ensembl1164,114,210 - 164,142,206 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114431   ⟹   ENSRNOP00000088100
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1153,454,080 - 153,470,403 (-)Ensembl
RefSeq Acc Id: NM_001012345   ⟹   NP_001012345
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21153,454,080 - 153,484,412 (-)NCBI
Rnor_6.01164,113,459 - 164,143,818 (-)NCBI
Rnor_5.01170,316,041 - 170,346,352 (-)NCBI
RGSC_v3.41156,447,588 - 156,478,740 (-)RGD
Celera1151,539,454 - 151,569,146 (-)RGD
Sequence:
RefSeq Acc Id: XM_006229733   ⟹   XP_006229795
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21153,454,080 - 153,466,318 (-)NCBI
Rnor_6.01164,113,459 - 164,126,055 (-)NCBI
Rnor_5.01170,316,041 - 170,346,352 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008759689   ⟹   XP_008757911
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21153,454,078 - 153,484,057 (-)NCBI
Rnor_6.01164,113,459 - 164,143,508 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039101533   ⟹   XP_038957461
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21153,454,080 - 153,484,432 (-)NCBI
RefSeq Acc Id: XM_039101534   ⟹   XP_038957462
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21153,454,078 - 153,465,143 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001012345   ⟸   NM_001012345
- UniProtKB: Q8K4Y4 (UniProtKB/Swiss-Prot),   Q5FVP8 (UniProtKB/Swiss-Prot),   A0A0G2JUZ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229795   ⟸   XM_006229733
- Peptide Label: isoform X3
- UniProtKB: A0A0G2JUZ8 (UniProtKB/TrEMBL),   A0A8I6A5T7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008757911   ⟸   XM_008759689
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A5T7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069294   ⟸   ENSRNOT00000081669
RefSeq Acc Id: ENSRNOP00000022557   ⟸   ENSRNOT00000022557
RefSeq Acc Id: XP_038957462   ⟸   XM_039101534
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038957461   ⟸   XM_039101533
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JUZ8 (UniProtKB/TrEMBL),   A0A8I6A5T7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000088100   ⟸   ENSRNOT00000114431

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5FVP8-F1-model_v2 AlphaFold Q5FVP8 1-388 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690224
Promoter ID:EPDNEW_R749
Type:multiple initiation site
Name:Dgat2_1
Description:diacylglycerol O-acyltransferase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01164,143,853 - 164,143,913EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620329 AgrOrtholog
BioCyc Gene G2FUF-58405 BioCyc
BioCyc Pathway TRIGLSYN-PWY [diacylglycerol and triacylglycerol biosynthesis] BioCyc
Ensembl Genes ENSRNOG00000016573 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022557 ENTREZGENE
  ENSRNOT00000022557.7 UniProtKB/TrEMBL
  ENSRNOT00000081669.2 UniProtKB/TrEMBL
  ENSRNOT00000114431 ENTREZGENE
  ENSRNOT00000114431.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7372077 IMAGE-MGC_LOAD
InterPro DAGAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:252900 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108863 IMAGE-MGC_LOAD
NCBI Gene 252900 ENTREZGENE
PANTHER DIACYLGLYCEROL O-ACYLTRANSFERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DIACYLGLYCEROL O-ACYLTRANSFERASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DAGAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dgat2 PhenoGen
RatGTEx ENSRNOG00000016573 RatGTEx
UniProt A0A0G2JUZ8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A5T7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QCK9_RAT UniProtKB/TrEMBL
  DGAT2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q8K4Y4 ENTREZGENE
UniProt Secondary Q8K4Y4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Dgat2  diacylglycerol O-acyltransferase 2  Dgat2  diacylglycerol O-acyltransferase homolog 2 (mouse)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Dgat2  diacylglycerol O-acyltransferase homolog 2 (mouse)  Dgat2  diacylglycerol O-acyltransferase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-19 Dgat2  diacylglycerol O-acyltransferase 2  Dgat2  diacylglycerol O-acyltransferase homolog 2 (mouse)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Dgat2  diacylglycerol O-acyltransferase homolog 2 (mouse)      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Dgat2  diacylglycerol O-acyltransferase homolog 2 (mouse)      Symbol and Name status set to provisional 70820 PROVISIONAL