Gene: Alas2 (5'-aminolevulinate synthase 2) Rattus norvegicus
Analyze
Symbol:
Alas2
Name:
5'-aminolevulinate synthase 2
RGD ID:
2084
Description:
Exhibits 5-aminolevulinate synthase activity and coenzyme A binding activity. Involved in several processes, including gland development; response to benzene; and response to lead ion. Localizes to mitochondrion. Biomarker of anemia; bilirubin metabolic disorder; and hemolytic anemia. Human ortholog(s) of this gene implicated in cutaneous porphyria; erythropoietic protoporphyria; hemochromatosis; sideroblastic anemia; and sideroblastic anemia 1. Orthologous to human ALAS2 (5'-aminolevulinate synthase 2); PARTICIPATES IN heme biosynthetic pathway; glycine, serine and threonine metabolic pathway; porphyrin and chlorophyll metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3,3',4,4',5-pentachlorobiphenyl.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
5-aminolevulinate synthase, erythroid-specific, mitochondrial; 5-aminolevulinic acid synthase 2; ALAS-E; Aminolevulinate synthase 2 delta; Aminolevulinate synthase 2, delta; aminolevulinate, delta-, synthase 2; aminolevulinic acid synthase 2; aminolevulinic acid synthase 2, erythroid; aminolevulinic acid synthase 2, erythroid-like; delta-ALA synthase 2; delta-ALA synthetase; delta-aminolevulinate synthase 2; erythroid-specific delta-aminolevulinate synthase ALAS-E; erythroid-specific delta-aminolevulinate synthase, ALAS-E; LOC100363476
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
ALAS2 (5'-aminolevulinate synthase 2) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Alas2 (aminolevulinic acid synthase 2, erythroid) HGNC
Treefam, OrthoMCL, NCBI, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Alas2 (5'-aminolevulinate synthase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
ALAS2 (5'-aminolevulinate synthase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
ALAS2 (5'-aminolevulinate synthase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Alas2 (5'-aminolevulinate synthase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
ALAS2 (5'-aminolevulinate synthase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
ALAS2 (5'-aminolevulinate synthase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Alas2 (5'-aminolevulinate synthase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
Alas2 (aminolevulinic acid synthase 2, erythroid)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Homo sapiens (human):
ALAS2 (5'-aminolevulinate synthase 2)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Danio rerio (zebrafish):
alas2 (aminolevulinate, delta-, synthase 2)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Drosophila melanogaster (fruit fly):
Alas
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):
HEM1
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 X 23,167,576 - 23,187,356 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl X 23,167,696 - 23,187,341 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 X 23,587,683 - 23,605,753 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.1 X 39,853,992 - 39,864,053 (+) NCBI Celera X 19,742,070 - 19,760,615 (+) NCBI Celera Cytogenetic Map X q13 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
RGD Manual Annotations
acute intermittent porphyria ISO RGD:736755 18337288 mRNA:increased expression:peripheral blood mononuclear cell (human) RGD anemia IEP 10449049 mRNA:decreased expression:liver: RGD bilirubin metabolic disorder IEP 11035235 protein:decreased activity:liver: RGD cutaneous porphyria severity ISO RGD:736755 11035240 DNA:mutation:exon: c.1757 A > T, p.Y586F (human) RGD Erythropoietic Protoporphyria, X-Linked Dominant disease_progression ISO RGD:736755 18337287 DNA:deletions:exon: c.1699-1700delAT, c.1706-1709delAGTG (human) RGD Erythropoietic Protoporphyria, X-Linked Dominant ISO RGD:736755 18337286 DNA:deletions:exon: c.1699-1700delAT, c.1706-1709delAGTG (human) RGD hemochromatosis severity ISO RGD:736755 11035246 DNA:mutation:cds:c.15599C>T, p.520L(human) RGD hemolytic anemia IEP 1599038 mRNA:increased expression:liver (rat) RGD sideroblastic anemia susceptibility ISO RGD:736755 1599037 DNA:transversion:cds:p.F165L (human) RGD sideroblastic anemia 1 onset ISO RGD:736755 11035243 DNA:mutation:exon: 1236 G> A, p.C395Y (human) RGD sideroblastic anemia 1 onset ISO RGD:736755 11035241 DNA:mutations:exons:p.K299Q, A172T(human) RGD sideroblastic anemia 1 ISO RGD:736755 11035244 DNA:missense mutations:cds:p.R452H, R452C, K156E(human) RGD
Imported Annotations - ClinVar
autistic disorder ISO RGD:736755 8554872 ClinVar Annotator: match by term: Autistic disorder of childhood onset ClinVar PMID:21681106 , PMID:30208311 Erythropoietic Protoporphyria, X-Linked Dominant ISO RGD:736755 8554872 ClinVar Annotator: match by OMIM:300752 ClinVar Erythropoietic Protoporphyria, X-Linked Dominant ISO RGD:736755 8554872 ClinVar Annotator: match by OMIM:300752 ClinVar PMID:18760763 Erythropoietic Protoporphyria, X-Linked Dominant ISO RGD:736755 8554872 ClinVar Annotator: match by OMIM:300752 ClinVar PMID:23263862 hypochromic anemia ISO RGD:736755 8554872 ClinVar Annotator: match by term: ANEMIA, HYPOCHROMIC ClinVar sideroblastic anemia 1 ISO RGD:736755 8554872 ClinVar Annotator: match by term: Anemia, sideroblastic, 1 ClinVar PMID:20848343 more ... sideroblastic anemia 1 ISO RGD:736755 8554872 ClinVar Annotator: match by term: Anemia, sideroblastic, 1 ClinVar PMID:18823803 , PMID:23315997 sideroblastic anemia 1 ISO RGD:736755 8554872 ClinVar Annotator: match by term: Anemia, sideroblastic, 1 ClinVar PMID:28492532 sideroblastic anemia 1 ISO RGD:736755 8554872 ClinVar Annotator: match by term: Hereditary sideroblastic anemia ClinVar PMID:25741868 , PMID:28492532 sideroblastic anemia 1 ISO RGD:736755 8554872 ClinVar Annotator: match by term: Anemia, sideroblastic, 1 ClinVar PMID:16446107 more ... sideroblastic anemia 1 ISO RGD:736755 8554872 ClinVar Annotator: match by term: Sideroblastic anemia 1, late-onset ClinVar PMID:7560104 sideroblastic anemia 1 ISO RGD:736755 8554872 ClinVar Annotator: match by term: Sideroblastic anemia 1, late-onset ClinVar PMID:16121195 , PMID:7560104 sideroblastic anemia 1 ISO RGD:736755 8554872 ClinVar Annotator: match by term: Hereditary sideroblastic anemia ClinVar sideroblastic anemia 1 ISO RGD:736755 8554872 ClinVar Annotator: match by OMIM:300751 ClinVar PMID:12663458 sideroblastic anemia 1 ISO RGD:736755 8554872 ClinVar Annotator: match by OMIM:300751 ClinVar PMID:16121195 , PMID:8107717 sideroblastic anemia 1 ISO RGD:736755 8554872 ClinVar Annotator: match by OMIM:300751 ClinVar PMID:11110715 , PMID:16121195 sideroblastic anemia 1 ISO RGD:736755 8554872 ClinVar Annotator: match by OMIM:300751 ClinVar PMID:16121195 , PMID:7705839 sideroblastic anemia 1 ISO RGD:736755 8554872 ClinVar Annotator: match by OMIM:300751 ClinVar PMID:16121195 , PMID:7949148 sideroblastic anemia 1 ISO RGD:736755 8554872 ClinVar Annotator: match by OMIM:300751 ClinVar PMID:9488633 sideroblastic anemia 1 ISO RGD:736755 8554872 ClinVar Annotator: match by OMIM:300751 ClinVar PMID:10444183 sideroblastic anemia 1 ISO RGD:736755 8554872 ClinVar Annotator: match by OMIM:300751 ClinVar PMID:12531813 sideroblastic anemia 1 ISO RGD:736755 8554872 ClinVar Annotator: match by OMIM:300751 ClinVar PMID:9858242 sideroblastic anemia 1 ISO RGD:736755 8554872 ClinVar Annotator: match by OMIM:300751 ClinVar PMID:1570328 sideroblastic anemia 1 ISO RGD:736755 8554872 ClinVar Annotator: match by OMIM:300751 ClinVar PMID:12031592 sideroblastic anemia 1 ISO RGD:736755 8554872 ClinVar Annotator: match by OMIM:300751 ClinVar PMID:10029606 syndromic X-linked intellectual disability Lubs type ISO RGD:736755 8554872 ClinVar Annotator: match by term: MECP2 duplication syndrome ClinVar PMID:25741868 X-linked sideroblastic anemia with ataxia ISO RGD:736755 8554872 ClinVar Annotator: match by term: Sideroblastic Anemia and Ataxia ClinVar
Imported Annotations - CTD
Experimental Liver Neoplasms ISO RGD:736755 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:11420682 sideroblastic anemia ISO RGD:736755 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16716198 , PMID:16892088 sideroblastic anemia 1 ISO RGD:736755 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18637800 Imported Annotations - MGI
erythropoietic protoporphyria ISS RGD:736755 13592920 OMIM:177000 , OMIM:300752MouseDO Imported Annotations - OMIM
Erythropoietic Protoporphyria, X-Linked Dominant ISO RGD:736755 7240710 OMIM sideroblastic anemia 1 ISO RGD:736755 7240710 OMIM
1,2-dichloroethane decreases expression ISO RGD:732282 6480464 ethylene dichloride results in decreased expression of ALAS2 mRNA CTD PMID:28189721 , PMID:28960355 17alpha-ethynylestradiol multiple interactions ISO RGD:732282 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ALAS2 mRNA CTD PMID:17942748 17beta-estradiol increases expression ISO RGD:732282 6480464 Estradiol results in increased expression of ALAS2 mRNA CTD PMID:16684588 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:732282 6480464 2 more ... CTD PMID:32352317 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of ALAS2 mRNA CTD PMID:16054898 , PMID:16466705 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:732282 6480464 Tetrachlorodibenzodioxin results in decreased expression of ALAS2 mRNA CTD PMID:28213091 , PMID:29673856 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:732282 6480464 Tetrachlorodibenzodioxin affects the expression of ALAS2 mRNA CTD PMID:28922406 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of ALAS2 mRNA CTD PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:732282 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ALAS2 mRNA CTD PMID:17942748 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of ALAS2 mRNA CTD PMID:21346803 3,3',4,4',5-pentachlorobiphenyl decreases expression EXP 6480464 3 more ... CTD PMID:20959002 3H-1,2-dithiole-3-thione decreases expression ISO RGD:732282 6480464 1, 2-dithiol-3-thione results in decreased expression of ALAS2 mRNA CTD PMID:15302862 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1, 2-dithiol-3-thione results in decreased expression of ALAS2 mRNA CTD PMID:19162173 4,4'-sulfonyldiphenol increases expression ISO RGD:732282 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of ALAS2 mRNA CTD PMID:30951980 4-hydroxyphenyl retinamide decreases expression ISO RGD:732282 6480464 Fenretinide results in decreased expression of ALAS2 mRNA CTD PMID:28973697 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of ALAS2 mRNA CTD PMID:24780913 , PMID:25825206 7,12-dimethyltetraphene increases expression EXP 6480464 9 more ... CTD PMID:19480007 acetamide decreases expression EXP 6480464 acetamide results in decreased expression of ALAS2 mRNA CTD PMID:31881176 aflatoxin B1 decreases methylation ISO RGD:736755 6480464 Aflatoxin B1 results in decreased methylation of ALAS2 gene CTD PMID:27153756 amiodarone decreases expression ISO RGD:732282 6480464 Amiodarone results in decreased expression of ALAS2 mRNA CTD PMID:24535564 antirheumatic drug decreases expression ISO RGD:736755 6480464 Antirheumatic Agents results in decreased expression of ALAS2 mRNA CTD PMID:24449571 arsenous acid increases expression ISO RGD:736755 6480464 Arsenic Trioxide results in increased expression of ALAS2 mRNA CTD PMID:20458559 astemizole increases expression EXP 6480464 Astemizole results in increased expression of ALAS2 mRNA CTD PMID:20221588 benzene decreases expression ISO RGD:732282 6480464 Benzene results in decreased expression of ALAS2 mRNA CTD PMID:15120971 , PMID:15122651 benzene affects expression EXP 6480464 Benzene affects the expression of ALAS2 mRNA CTD PMID:15878777 benzo[a]pyrene decreases expression ISO RGD:732282 6480464 Benzo(a)pyrene results in decreased expression of ALAS2 mRNA CTD PMID:21569818 , PMID:27195522 benzo[a]pyrene decreases methylation ISO RGD:736755 6480464 Benzo(a)pyrene results in decreased methylation of ALAS2 5' UTR CTD PMID:27901495 benzo[a]pyrene increases methylation ISO RGD:736755 6480464 Benzo(a)pyrene results in increased methylation of ALAS2 promoter CTD PMID:27901495 benzo[b]fluoranthene decreases expression ISO RGD:732282 6480464 benzo(b)fluoranthene results in decreased expression of ALAS2 mRNA CTD PMID:26377693 beta-naphthoflavone multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ALAS2 mRNA CTD PMID:18164116 bisphenol A decreases expression ISO RGD:732282 6480464 bisphenol A results in decreased expression of ALAS2 mRNA CTD PMID:26063408 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of ALAS2 mRNA CTD PMID:30816183 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of ALAS2 mRNA CTD PMID:25181051 cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of ALAS2 mRNA CTD PMID:25993096 carbamazepine affects expression ISO RGD:736755 6480464 Carbamazepine affects the expression of ALAS2 mRNA CTD PMID:24752500 carbon nanotube decreases expression ISO RGD:732282 6480464 Nanotubes, Carbon results in decreased expression of ALAS2 mRNA CTD PMID:25554681 carbonyl sulfide decreases expression EXP 6480464 carbonyl sulfide results in decreased expression of ALAS2 mRNA CTD PMID:19395590 carboplatin decreases expression EXP 6480464 Carboplatin results in decreased expression of ALAS2 mRNA CTD PMID:21296123 carmustine decreases expression EXP 6480464 Carmustine results in decreased expression of ALAS2 mRNA CTD PMID:16005536 catechol increases expression ISO RGD:736755 6480464 catechol results in increased expression of ALAS2 mRNA CTD PMID:23022512 , PMID:28552822 catechol multiple interactions ISO RGD:736755 6480464 [catechol co-treated with Hemin] results in increased expression of ALAS2 mRNA more ... CTD PMID:24141029 , PMID:28552822 chloroprene decreases expression EXP 6480464 Chloroprene results in decreased expression of ALAS2 mRNA CTD PMID:23125180 cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of ALAS2 mRNA CTD PMID:21296123 clofibrate multiple interactions ISO RGD:732282 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of ALAS2 mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ALAS2 mRNA] CTD PMID:17585979 copper atom multiple interactions EXP 6480464 [Copper co-treated with Dietary Sucrose] results in increased expression of ALAS2 mRNA CTD PMID:26033743 copper atom increases expression ISO RGD:732282 6480464 Copper results in increased expression of ALAS2 mRNA CTD PMID:17205981 copper atom increases expression EXP 6480464 Copper deficiency results in increased expression of ALAS2 mRNA CTD PMID:26033743 copper(0) multiple interactions EXP 6480464 [Copper co-treated with Dietary Sucrose] results in increased expression of ALAS2 mRNA CTD PMID:26033743 copper(0) increases expression ISO RGD:732282 6480464 Copper results in increased expression of ALAS2 mRNA CTD PMID:17205981 copper(0) increases expression EXP 6480464 Copper deficiency results in increased expression of ALAS2 mRNA CTD PMID:26033743 crocidolite asbestos decreases expression ISO RGD:732282 6480464 Asbestos, Crocidolite results in decreased expression of ALAS2 mRNA CTD PMID:29279043 diarsenic trioxide increases expression ISO RGD:736755 6480464 Arsenic Trioxide results in increased expression of ALAS2 mRNA CTD PMID:20458559 dibutyl phthalate increases expression ISO RGD:732282 6480464 Dibutyl Phthalate results in increased expression of ALAS2 mRNA CTD PMID:21266533 dichloroacetic acid decreases expression ISO RGD:732282 6480464 Dichloroacetic Acid results in decreased expression of ALAS2 mRNA CTD PMID:28962523 diclofenac affects expression ISO RGD:736755 6480464 Diclofenac affects the expression of ALAS2 mRNA CTD PMID:24752500 dimethyl sulfoxide increases expression ISO RGD:732282 6480464 Dimethyl Sulfoxide results in increased expression of ALAS2 mRNA CTD PMID:21296123 dioxygen multiple interactions ISO RGD:732282 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of ALAS2 mRNA CTD PMID:30529165 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of ALAS2 mRNA CTD PMID:19915844 doxorubicin decreases expression ISO RGD:732282 6480464 Doxorubicin results in decreased expression of ALAS2 mRNA CTD PMID:28608983 ethanol affects expression ISO RGD:732282 6480464 Ethanol affects the expression of ALAS2 mRNA CTD PMID:19167417 ferroheme b decreases expression ISO RGD:732282 6480464 Heme metabolite results in decreased expression of ALAS2 mRNA CTD PMID:19191707 gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of ALAS2 mRNA CTD PMID:22061828 heme b decreases expression ISO RGD:732282 6480464 Heme metabolite results in decreased expression of ALAS2 mRNA CTD PMID:19191707 hemin multiple interactions ISO RGD:736755 6480464 [catechol co-treated with Hemin] results in increased expression of ALAS2 mRNA more ... CTD PMID:23973255 more ... hemin increases expression ISO RGD:736755 6480464 Hemin results in increased expression of ALAS2 mRNA CTD PMID:23973255 , PMID:28552822 hexachlorobenzene increases expression EXP 6480464 Hexachlorobenzene results in increased expression of ALAS2 mRNA CTD PMID:15159207 indole-3-methanol affects expression EXP 6480464 indole-3-carbinol affects the expression of ALAS2 mRNA CTD PMID:21396975 irinotecan increases expression ISO RGD:736755 6480464 Irinotecan metabolite results in increased expression of ALAS2 mRNA, Irinotecan results in increased expression of ALAS2 mRNA CTD PMID:15956246 iron atom increases expression ISO RGD:732282 6480464 Iron results in increased expression of ALAS2 mRNA CTD PMID:16424395 iron(0) increases expression ISO RGD:732282 6480464 Iron results in increased expression of ALAS2 mRNA CTD PMID:16424395 lead diacetate increases expression EXP 6480464 lead acetate results in increased expression of ALAS2 mRNA CTD PMID:22641619 linalool decreases expression EXP 6480464 linalool results in decreased expression of ALAS2 mRNA CTD PMID:20536181 linezolid decreases expression EXP 6480464 Linezolid results in decreased expression of ALAS2 mRNA CTD PMID:21296123 maneb multiple interactions ISO RGD:732282 6480464 [Paraquat co-treated with Maneb] affects the expression of ALAS2 mRNA CTD PMID:22563483 metformin decreases expression EXP 6480464 Metformin results in decreased expression of ALAS2 mRNA CTD PMID:31324951 methimazole increases expression EXP 6480464 Methimazole results in increased expression of ALAS2 mRNA CTD PMID:20144635 methotrexate decreases expression EXP 6480464 Methotrexate results in decreased expression of ALAS2 mRNA CTD PMID:16005536 , PMID:24136188 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ALAS2 mRNA CTD PMID:18164116 N-nitrosodiethylamine decreases expression ISO RGD:732282 6480464 Diethylnitrosamine results in decreased expression of ALAS2 mRNA CTD PMID:24535843 ozone decreases expression ISO RGD:732282 6480464 Ozone results in decreased expression of ALAS2 mRNA CTD PMID:12763052 paracetamol affects expression ISO RGD:732282 6480464 Acetaminophen affects the expression of ALAS2 mRNA CTD PMID:15606129 , PMID:17562736 paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of ALAS2 mRNA CTD PMID:30723492 paracetamol decreases expression ISO RGD:732282 6480464 Acetaminophen results in decreased expression of ALAS2 mRNA CTD PMID:29246445 paracetamol multiple interactions ISO RGD:732282 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of ALAS2 mRNA more ... CTD PMID:17585979 , PMID:29246445 paraquat multiple interactions ISO RGD:732282 6480464 [Paraquat co-treated with Maneb] affects the expression of ALAS2 mRNA CTD PMID:22563483 phenacetin increases expression EXP 6480464 Phenacetin results in increased expression of ALAS2 mRNA CTD PMID:17082564 phenformin decreases expression EXP 6480464 Phenformin results in decreased expression of ALAS2 mRNA CTD PMID:31324951 phenol multiple interactions ISO RGD:736755 6480464 Phenol inhibits the reaction [Hemin results in increased expression of ALAS2 mRNA] CTD PMID:23973255 phenylhydrazine increases expression EXP 6480464 phenylhydrazine results in increased expression of ALAS2 mRNA CTD PMID:17082564 pirinixic acid multiple interactions ISO RGD:732282 6480464 [pirinixic acid co-treated with PPARA] results in decreased expression of ALAS2 mRNA, PPARA protein promotes the reaction [pirinixic acid results in decreased expression of ALAS2 mRNA] CTD PMID:20059764 , PMID:20813756 pirinixic acid decreases expression ISO RGD:732282 6480464 pirinixic acid results in decreased expression of ALAS2 mRNA CTD PMID:15302862 more ... pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of ALAS2 mRNA CTD PMID:19162173 potassium dichromate decreases expression ISO RGD:732282 6480464 Potassium Dichromate results in decreased expression of ALAS2 mRNA CTD PMID:23608068 progesterone affects expression ISO RGD:732282 6480464 Progesterone affects the expression of ALAS2 mRNA CTD PMID:17251523 raloxifene affects expression EXP 6480464 Raloxifene Hydrochloride affects the expression of ALAS2 mRNA CTD PMID:16079270 rotenone affects expression EXP 6480464 Rotenone affects the expression of ALAS2 mRNA CTD PMID:28374803 S-adenosyl-L-homocysteine multiple interactions ISO RGD:736755 6480464 [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA, catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA] CTD PMID:24141029 S-adenosyl-L-methioninate multiple interactions ISO RGD:736755 6480464 [S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA, catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA] CTD PMID:24141029 S-adenosyl-L-methionine multiple interactions ISO RGD:736755 6480464 [S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA, catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA] CTD PMID:24141029 sodium arsenate decreases expression ISO RGD:732282 6480464 sodium arsenate results in decreased expression of ALAS2 mRNA CTD PMID:21795629 sodium arsenate increases expression ISO RGD:732282 6480464 sodium arsenate results in increased expression of ALAS2 mRNA CTD PMID:30953684 sodium arsenite decreases expression ISO RGD:732282 6480464 sodium arsenite results in decreased expression of ALAS2 mRNA CTD PMID:17682005 sodium dichromate decreases expression ISO RGD:732282 6480464 sodium bichromate results in decreased expression of ALAS2 mRNA CTD PMID:22155349 testosterone increases expression ISO RGD:732282 6480464 Testosterone results in increased expression of ALAS2 mRNA CTD PMID:21669218 tetrachloromethane decreases expression ISO RGD:732282 6480464 Carbon Tetrachloride results in decreased expression of ALAS2 mRNA CTD PMID:27339419 , PMID:31919559 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of ALAS2 mRNA CTD PMID:30723492 thioacetamide decreases expression EXP 6480464 Thioacetamide results in decreased expression of ALAS2 mRNA CTD PMID:23411599 tioguanine decreases expression EXP 6480464 Thioguanine results in decreased expression of ALAS2 mRNA CTD PMID:16005536 trichloroethene decreases methylation EXP 6480464 Trichloroethylene results in decreased methylation of ALAS2 gene CTD PMID:27618143 triphenyl phosphate decreases expression EXP 6480464 triphenyl phosphate results in decreased expression of ALAS2 mRNA CTD PMID:30589522 tungsten decreases expression ISO RGD:732282 6480464 Tungsten results in decreased expression of ALAS2 mRNA CTD PMID:30912803 valproic acid affects expression ISO RGD:732282 6480464 Valproic Acid affects the expression of ALAS2 mRNA CTD PMID:17292431 valproic acid decreases expression ISO RGD:732282 6480464 Valproic Acid results in decreased expression of ALAS2 mRNA CTD PMID:24535564 valproic acid decreases methylation ISO RGD:736755 6480464 Valproic Acid results in decreased methylation of ALAS2 gene CTD PMID:29154799 vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of ALAS2 mRNA CTD PMID:19015723 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of ALAS2 mRNA CTD PMID:23034163
Biological Process cellular iron ion homeostasis IEA UniProtKB:P08680 , ensembl:ENSMUSP000000660401600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular iron ion homeostasis ISO RGD:732282 1624291 MGI:2180151 (MGI:1347738 , PMID:10562540) RGD MGI:1347738 , PMID:10562540 erythrocyte development IBA PANTHER:PTN000343740 , ZFIN:ZDB-GENE-001229-1 13792537 PMID:21873635 GO_Central erythrocyte differentiation IEA UniProtKB:P08680 , ensembl:ENSMUSP000000660401600115 GO_REF:0000107 Ensembl GO_REF:0000107 erythrocyte differentiation ISO RGD:732282 1624291 (MGI:3694153, PMID:9446639) RGD MGI:3694153 , PMID:9446639 erythrocyte differentiation ISS UniProtKB:P08680 1600115 GO_REF:0000024 UniProt GO_REF:0000024 heme biosynthetic process IBA CGD:CAL0000189686 more ... 13792537 PMID:21873635 GO_Central heme biosynthetic process ISO RGD:732282 1624291 (MGI:3694153, PMID:9446639) RGD MGI:3694153 , PMID:9446639 heme biosynthetic process ISS UniProtKB:P08680 1600115 GO_REF:0000024 UniProt GO_REF:0000024 hemoglobin biosynthetic process IBA MGI:MGI:87990 more ... 13792537 PMID:21873635 GO_Central hemoglobin biosynthetic process ISO RGD:732282 1624291 (MGI:3694153, PMID:9446639) RGD MGI:3694153 , PMID:9446639 hemoglobin biosynthetic process ISS UniProtKB:P08680 1600115 GO_REF:0000024 UniProt GO_REF:0000024 hemoglobin biosynthetic process IEA UniProtKB:P08680 , ensembl:ENSMUSP000000660401600115 GO_REF:0000107 Ensembl GO_REF:0000107 lactation IEP 4144779 RGD liver regeneration IEP 11035238 RGD maternal process involved in female pregnancy IEP 4144779 RGD protoporphyrinogen IX biosynthetic process IEA UniPathway:UPA00251 1600115 GO_REF:0000041 UniProt GO_REF:0000041 response to benzene IEP 11035239 RGD response to cobalt ion IEP 11035236 RGD response to drug IEP 10449049 RGD response to drug IEP 4144195 carmustine, thioguanine, methotrexate RGD response to fatty acid IEP 11035225 RGD response to hypoxia IEP 1599040 RGD response to hypoxia ISS UniProtKB:P22557 1600115 GO_REF:0000024 UniProt GO_REF:0000024 response to hypoxia IEA UniProtKB:P22557 , ensembl:ENSP000004972361600115 GO_REF:0000107 Ensembl GO_REF:0000107 response to hypoxia IBA PANTHER:PTN000343737 more ... 13792537 PMID:21873635 GO_Central response to hypoxia ISO RGD:736755 1624291 (PMID:16234850) RGD PMID:16234850 response to lead ion IEP 1599014 RGD Cellular Component mitochondrial inner membrane ISO RGD:736755 1624291 (PMID:14643893) RGD PMID:14643893 mitochondrial inner membrane ISS UniProtKB:P22557 1600115 GO_REF:0000024 UniProt GO_REF:0000024 mitochondrial inner membrane IEA UniProtKB:P22557 , ensembl:ENSP000004972361600115 GO_REF:0000107 Ensembl GO_REF:0000107 mitochondrial matrix IEA UniProtKB-SubCell:SL-0170 1600115 GO_REF:0000044 UniProt GO_REF:0000044 mitochondrion IDA 1581087 RGD mitochondrion ISO RGD:736755 1624291 (PMID:10727444), (PMID:14643893) RGD PMID:10727444 , PMID:14643893 mitochondrion ISS UniProtKB:P22557 1600115 GO_REF:0000024 UniProt GO_REF:0000024 mitochondrion IBA PANTHER:PTN000343737 more ... 13792537 PMID:21873635 GO_Central Molecular Function 5-aminolevulinate synthase activity IDA 632181 ; 1581096 RGD 5-aminolevulinate synthase activity ISO RGD:732282 1624291 (MGI:75768, PMID:7620186) RGD MGI:75768 , PMID:7620186 5-aminolevulinate synthase activity ISS UniProtKB:P22557 1600115 GO_REF:0000024 UniProt GO_REF:0000024 5-aminolevulinate synthase activity IEA EC:2.3.1.37 1600115 GO_REF:0000003 UniProt GO_REF:0000003 5-aminolevulinate synthase activity IBA CGD:CAL0000189686 more ... 13792537 PMID:21873635 GO_Central 5-aminolevulinate synthase activity ISO RGD:736755 1624291 (PMID:14643893) RGD PMID:14643893 coenzyme A binding IDA 632181 RGD protein binding ISO RGD:736755 1624291 UniProtKB:P40337 more ... RGD PMID:10727444 more ... pyridoxal phosphate binding IEA InterPro:IPR004839 more ... 1600115 GO_REF:0000002 InterPro GO_REF:0000002 pyridoxal phosphate binding IEA UniRule:UR000079120 1600115 GO_REF:0000104 UniProt GO_REF:0000104
Gene-Chemical Interaction Annotations
