Ect2 (epithelial cell transforming 2) - Rat Genome Database

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Gene: Ect2 (epithelial cell transforming 2) Rattus norvegicus
Analyze
Symbol: Ect2
Name: epithelial cell transforming 2
RGD ID: 1308524
Description: Predicted to enable GTPase regulator activity; protein homodimerization activity; and small GTPase binding activity. Predicted to be involved in several processes, including activation of GTPase activity; bicellular tight junction assembly; and regulation of cell cycle process. Predicted to act upstream of or within cell morphogenesis. Predicted to be located in several cellular components, including bicellular tight junction; cleavage furrow; and midbody. Predicted to be part of centralspindlin complex. Predicted to be active in cell cortex and nucleus. Orthologous to human ECT2 (epithelial cell transforming 2); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ect2 oncogene; epithelial cell transforming sequence 2 oncogene; LOC361921
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82111,904,522 - 111,966,786 (-)NCBIGRCr8
mRatBN7.22109,975,813 - 110,037,911 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2109,975,813 - 110,037,911 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2116,622,334 - 116,684,276 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02114,734,899 - 114,796,847 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02109,460,986 - 109,522,616 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02112,769,385 - 112,831,476 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2112,769,385 - 112,831,476 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02132,490,047 - 132,552,138 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42112,969,261 - 113,001,056 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12112,915,386 - 112,971,181 (-)NCBI
Celera2105,188,023 - 105,250,067 (-)NCBICelera
Cytogenetic Map2q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
5-fluorouracil  (ISO)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
dimethylarsinic acid  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
erythromycin estolate  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP,ISO)
genistein  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
glycine betaine  (EXP)
heptachlor  (EXP)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
lidocaine  (EXP)
lithium atom  (EXP)
lithium hydride  (EXP)
lucanthone  (ISO)
methamphetamine  (EXP)
methylmercury chloride  (ISO)
mirex  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
Soman  (EXP)
succimer  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8464478   PMID:12477932   PMID:12761501   PMID:15254234   PMID:15545273   PMID:15642749   PMID:16103226   PMID:16236794   PMID:17115030   PMID:17904126   PMID:19468300   PMID:19617897  
PMID:20047078   PMID:21350944   PMID:21373644   PMID:25807302  


Genomics

Comparative Map Data
Ect2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82111,904,522 - 111,966,786 (-)NCBIGRCr8
mRatBN7.22109,975,813 - 110,037,911 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2109,975,813 - 110,037,911 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2116,622,334 - 116,684,276 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02114,734,899 - 114,796,847 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02109,460,986 - 109,522,616 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02112,769,385 - 112,831,476 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2112,769,385 - 112,831,476 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02132,490,047 - 132,552,138 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42112,969,261 - 113,001,056 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12112,915,386 - 112,971,181 (-)NCBI
Celera2105,188,023 - 105,250,067 (-)NCBICelera
Cytogenetic Map2q24NCBI
ECT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383172,750,726 - 172,829,265 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3172,750,682 - 172,821,474 (+)EnsemblGRCh38hg38GRCh38
GRCh373172,468,516 - 172,539,264 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363173,951,336 - 174,021,957 (+)NCBINCBI36Build 36hg18NCBI36
Build 343173,954,999 - 174,021,965NCBI
Celera3170,871,530 - 170,938,230 (+)NCBICelera
Cytogenetic Map3q26.31NCBI
HuRef3169,839,394 - 169,910,198 (+)NCBIHuRef
CHM1_13172,431,384 - 172,502,159 (+)NCBICHM1_1
T2T-CHM13v2.03175,536,482 - 175,615,021 (+)NCBIT2T-CHM13v2.0
Ect2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39327,151,371 - 27,207,971 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl327,151,371 - 27,208,027 (-)EnsemblGRCm39 Ensembl
GRCm38327,097,222 - 27,154,253 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl327,097,222 - 27,153,878 (-)EnsemblGRCm38mm10GRCm38
MGSCv37326,996,144 - 27,052,800 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36327,288,299 - 27,344,909 (-)NCBIMGSCv36mm8
Celera327,060,619 - 27,116,904 (-)NCBICelera
Cytogenetic Map3A3NCBI
cM Map310.82NCBI
Ect2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554202,768,800 - 2,828,230 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554202,769,542 - 2,827,843 (+)NCBIChiLan1.0ChiLan1.0
ECT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22170,629,032 - 170,703,238 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13170,633,750 - 170,707,956 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03169,756,885 - 169,828,087 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13177,938,161 - 178,008,381 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3177,938,164 - 178,008,381 (+)Ensemblpanpan1.1panPan2
ECT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13436,897,441 - 36,958,501 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3436,896,958 - 36,958,384 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3445,907,851 - 45,969,821 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03436,981,676 - 37,043,349 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3436,981,698 - 37,043,292 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13436,919,236 - 36,980,903 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03436,888,783 - 36,950,259 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03437,146,019 - 37,207,403 (+)NCBIUU_Cfam_GSD_1.0
Ect2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602103,592,041 - 103,679,947 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049367035,744 - 45,636 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ECT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13111,248,131 - 111,314,828 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113111,248,215 - 111,310,746 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ECT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11516,612,738 - 16,685,455 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1516,612,443 - 16,685,386 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606325,373,942 - 25,446,633 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ect2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473050,773,566 - 50,840,510 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473050,773,465 - 50,841,427 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ect2
542 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:566
Count of miRNA genes:216
Interacting mature miRNAs:264
Transcripts:ENSRNOT00000018055, ENSRNOT00000067467
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
1598862Glom9Glomerulus QTL 93.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)292337601137337601Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
1598863Cm65Cardiac mass QTL 652.3heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)292337601137337601Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
2300165Bmd49Bone mineral density QTL 494.80.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)288862519133862519Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
2300170Bmd45Bone mineral density QTL 4512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
7411551Bw131Body weight QTL 13129.60.001body mass (VT:0001259)body weight gain (CMO:0000420)267942638112942638Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
2300185Bmd46Bone mineral density QTL 468.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)280270434125270434Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
7207808Bmd89Bone mineral density QTL 894.1femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)288862519133862519Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat

Markers in Region
BE117772  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22109,996,795 - 109,996,954 (+)MAPPERmRatBN7.2
Rnor_6.02112,790,367 - 112,790,525NCBIRnor6.0
Rnor_5.02132,511,029 - 132,511,187UniSTSRnor5.0
RGSC_v3.42112,990,242 - 112,990,400UniSTSRGSC3.4
Celera2105,209,027 - 105,209,185UniSTS
RH 3.4 Map2724.2UniSTS
Cytogenetic Map2q24UniSTS
RH140767  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera2105,188,240 - 105,188,378UniSTS
RH 3.4 Map2724.2UniSTS
Cytogenetic Map2q24UniSTS
AU049848  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22109,981,513 - 109,981,710 (+)MAPPERmRatBN7.2
Rnor_6.02112,775,086 - 112,775,282NCBIRnor6.0
Rnor_5.02132,495,748 - 132,495,944UniSTSRnor5.0
RGSC_v3.42112,974,961 - 112,975,157UniSTSRGSC3.4
Celera2105,193,740 - 105,193,942UniSTS
Cytogenetic Map2q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000018055   ⟹   ENSRNOP00000018055
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2109,975,813 - 110,037,911 (-)Ensembl
Rnor_6.0 Ensembl2112,769,385 - 112,831,476 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2109,975,813 - 110,031,386 (-)Ensembl
Rnor_6.0 Ensembl2112,770,443 - 112,831,443 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093010
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2109,975,816 - 110,033,146 (-)Ensembl
Rnor_6.0 Ensembl2112,770,417 - 112,831,383 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093081   ⟹   ENSRNOP00000076063
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2109,975,818 - 110,008,500 (-)Ensembl
Rnor_6.0 Ensembl2112,769,388 - 112,802,073 (-)Ensembl
RefSeq Acc Id: NM_001108547   ⟹   NP_001102017
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82111,904,522 - 111,966,626 (-)NCBI
mRatBN7.22109,975,813 - 110,037,911 (-)NCBI
Rnor_6.02112,769,385 - 112,831,476 (-)NCBI
Rnor_5.02132,490,047 - 132,552,138 (-)NCBI
RGSC_v3.42112,969,261 - 113,001,056 (-)RGD
Celera2105,188,023 - 105,250,067 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063282043   ⟹   XP_063138113
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82111,904,522 - 111,966,756 (-)NCBI
RefSeq Acc Id: XM_063282044   ⟹   XP_063138114
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82111,904,522 - 111,966,747 (-)NCBI
RefSeq Acc Id: XM_063282045   ⟹   XP_063138115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82111,904,522 - 111,966,367 (-)NCBI
RefSeq Acc Id: XM_063282046   ⟹   XP_063138116
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82111,904,522 - 111,966,747 (-)NCBI
RefSeq Acc Id: XM_063282047   ⟹   XP_063138117
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82111,904,522 - 111,966,786 (-)NCBI
RefSeq Acc Id: XM_063282048   ⟹   XP_063138118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82111,904,522 - 111,966,746 (-)NCBI
RefSeq Acc Id: XM_063282049   ⟹   XP_063138119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82111,904,522 - 111,966,746 (-)NCBI
RefSeq Acc Id: XM_063282050   ⟹   XP_063138120
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82111,904,522 - 111,966,746 (-)NCBI
RefSeq Acc Id: XR_010063624
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82111,927,998 - 111,966,749 (-)NCBI
RefSeq Acc Id: NP_001102017   ⟸   NM_001108547
- UniProtKB: D3ZUD0 (UniProtKB/TrEMBL),   A0A8I6GJ38 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018055   ⟸   ENSRNOT00000018055
Ensembl Acc Id: ENSRNOP00000076063   ⟸   ENSRNOT00000093081
RefSeq Acc Id: XP_063138117   ⟸   XM_063282047
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GJ38 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138113   ⟸   XM_063282043
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GJ38 (UniProtKB/TrEMBL),   D3ZUD0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138116   ⟸   XM_063282046
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GJ38 (UniProtKB/TrEMBL),   D3ZUD0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138114   ⟸   XM_063282044
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GJ38 (UniProtKB/TrEMBL),   D3ZUD0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138120   ⟸   XM_063282050
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GJ38 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138118   ⟸   XM_063282048
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GJ38 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138119   ⟸   XM_063282049
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GJ38 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138115   ⟸   XM_063282045
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GJ38 (UniProtKB/TrEMBL),   D3ZUD0 (UniProtKB/TrEMBL)
Protein Domains
BRCT   DH   ECT2 PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZUD0-F1-model_v2 AlphaFold D3ZUD0 1-912 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691267
Promoter ID:EPDNEW_R1787
Type:multiple initiation site
Name:Ect2_1
Description:epithelial cell transforming 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02112,831,474 - 112,831,534EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308524 AgrOrtholog
BioCyc Gene G2FUF-53517 BioCyc
Ensembl Genes ENSRNOG00000024365 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018055.9 UniProtKB/TrEMBL
  ENSRNOT00000092855.2 UniProtKB/TrEMBL
  ENSRNOT00000093010.2 UniProtKB/TrEMBL
  ENSRNOT00000093081.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  3.40.50.10190 UniProtKB/TrEMBL
InterPro BRCT_dom UniProtKB/TrEMBL
  BRCT_dom_sf UniProtKB/TrEMBL
  DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  Ect2 UniProtKB/TrEMBL
  ECT2_BRCT0 UniProtKB/TrEMBL
  ECT2_PH UniProtKB/TrEMBL
  GDS_CDC24_CS UniProtKB/TrEMBL
  PH_like_dom UniProtKB/TrEMBL
KEGG Report rno:361921 UniProtKB/TrEMBL
NCBI Gene 361921 ENTREZGENE
PANTHER PROTEIN ECT2 UniProtKB/TrEMBL
  PTHR16777 UniProtKB/TrEMBL
Pfam BRCT UniProtKB/TrEMBL
  ECT2_BRCT0 UniProtKB/TrEMBL
  ECT2_PH UniProtKB/TrEMBL
  PTCB-BRCT UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
PhenoGen Ect2 PhenoGen
PROSITE BRCT UniProtKB/TrEMBL
  DH_1 UniProtKB/TrEMBL
  DH_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000024365 RatGTEx
SMART BRCT UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
Superfamily-SCOP BRCT UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
UniProt A0A1B0GWY1_RAT UniProtKB/TrEMBL
  A0A8I6AQ76_RAT UniProtKB/TrEMBL
  A0A8I6GJ38 ENTREZGENE, UniProtKB/TrEMBL
  B5DF83_RAT UniProtKB/TrEMBL
  D3ZUD0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-21 Ect2  epithelial cell transforming 2  Ect2  epithelial cell transforming sequence 2 oncogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-17 Ect2  epithelial cell transforming sequence 2 oncogene  Ect2  ect2 oncogene   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ect2  ect2 oncogene   Ect2_predicted  ect2 oncogene (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ect2_predicted  ect2 oncogene (predicted)      Symbol and Name status set to approved 70820 APPROVED