Ect2 (epithelial cell transforming 2) - Rat Genome Database

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Gene: Ect2 (epithelial cell transforming 2) Rattus norvegicus
Analyze
Symbol: Ect2
Name: epithelial cell transforming 2
RGD ID: 1308524
Description: Predicted to enable GTPase regulator activity; protein homodimerization activity; and small GTPase binding activity. Predicted to be involved in several processes, including activation of GTPase activity; bicellular tight junction assembly; and regulation of cell cycle process. Predicted to act upstream of or within cell morphogenesis. Predicted to be located in several cellular components, including bicellular tight junction; cleavage furrow; and midbody. Predicted to be part of centralspindlin complex. Predicted to be active in cell cortex and nucleus. Orthologous to human ECT2 (epithelial cell transforming 2); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ect2 oncogene; epithelial cell transforming sequence 2 oncogene; LOC361921
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82111,904,522 - 111,966,786 (-)NCBIGRCr8
GRCr8 Ensembl2111,904,522 - 111,966,626 (-)EnsemblGRCr8 Ensembl
mRatBN7.22109,975,813 - 110,037,911 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2109,975,813 - 110,037,911 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2116,622,334 - 116,684,276 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02114,734,899 - 114,796,847 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02109,460,986 - 109,522,616 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02112,769,385 - 112,831,476 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2112,769,385 - 112,831,476 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02132,490,047 - 132,552,138 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42112,969,261 - 113,001,056 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2105,188,023 - 105,250,067 (-)NCBICelera
RGSC_v3.12112,915,386 - 112,971,181 (-)NCBI
Cytogenetic Map2q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
dimethylarsinic acid  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
erythromycin estolate  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP,ISO)
genistein  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
glycine betaine  (EXP)
heptachlor  (EXP)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
lidocaine  (EXP)
lithium atom  (EXP)
lithium hydride  (EXP)
lucanthone  (ISO)
methamphetamine  (EXP)
methylmercury chloride  (ISO)
mirex  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
Soman  (EXP)
succimer  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
anchoring junction  (IEA)
bicellular tight junction  (IEA,ISO)
cell cortex  (IBA)
cell-cell junction  (IEA,ISO)
centralspindlin complex  (IEA,ISO)
cleavage furrow  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytoskeleton  (IEA)
cytosol  (IEA,ISO)
midbody  (IEA,ISO)
mitotic spindle  (IEA,ISO)
nuclear body  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
spindle  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8464478   PMID:12477932   PMID:12761501   PMID:15254234   PMID:15545273   PMID:15642749   PMID:16103226   PMID:16236794   PMID:17115030   PMID:17904126   PMID:19468300   PMID:19617897  
PMID:20047078   PMID:21350944   PMID:21373644   PMID:25807302  


Genomics

Comparative Map Data
Ect2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82111,904,522 - 111,966,786 (-)NCBIGRCr8
GRCr8 Ensembl2111,904,522 - 111,966,626 (-)EnsemblGRCr8 Ensembl
mRatBN7.22109,975,813 - 110,037,911 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2109,975,813 - 110,037,911 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2116,622,334 - 116,684,276 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02114,734,899 - 114,796,847 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02109,460,986 - 109,522,616 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02112,769,385 - 112,831,476 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2112,769,385 - 112,831,476 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02132,490,047 - 132,552,138 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42112,969,261 - 113,001,056 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2105,188,023 - 105,250,067 (-)NCBICelera
RGSC_v3.12112,915,386 - 112,971,181 (-)NCBI
Cytogenetic Map2q24NCBI
ECT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383172,750,726 - 172,829,265 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3172,750,682 - 172,821,474 (+)EnsemblGRCh38hg38GRCh38
GRCh373172,468,516 - 172,539,264 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363173,951,336 - 174,021,957 (+)NCBINCBI36Build 36hg18NCBI36
Build 343173,954,999 - 174,021,965NCBI
Celera3170,871,530 - 170,938,230 (+)NCBICelera
Cytogenetic Map3q26.31NCBI
HuRef3169,839,394 - 169,910,198 (+)NCBIHuRef
CHM1_13172,431,384 - 172,502,159 (+)NCBICHM1_1
T2T-CHM13v2.03175,536,482 - 175,615,021 (+)NCBIT2T-CHM13v2.0
Ect2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39327,151,371 - 27,207,971 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl327,151,371 - 27,208,027 (-)EnsemblGRCm39 Ensembl
GRCm38327,097,222 - 27,154,253 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl327,097,222 - 27,153,878 (-)EnsemblGRCm38mm10GRCm38
MGSCv37326,996,144 - 27,052,800 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36327,288,299 - 27,344,909 (-)NCBIMGSCv36mm8
Celera327,060,619 - 27,116,904 (-)NCBICelera
Cytogenetic Map3A3NCBI
cM Map310.82NCBI
Ect2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554202,768,800 - 2,828,230 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554202,769,542 - 2,827,843 (+)NCBIChiLan1.0ChiLan1.0
ECT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22170,629,032 - 170,703,238 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13170,633,750 - 170,707,956 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03169,756,885 - 169,828,087 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13177,938,161 - 178,008,381 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3177,938,164 - 178,008,381 (+)Ensemblpanpan1.1panPan2
ECT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13436,897,441 - 36,958,501 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3436,896,958 - 36,958,384 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3445,907,851 - 45,969,821 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03436,981,676 - 37,043,349 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3436,981,698 - 37,043,292 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13436,919,236 - 36,980,903 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03436,888,783 - 36,950,259 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03437,146,019 - 37,207,403 (+)NCBIUU_Cfam_GSD_1.0
Ect2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602103,592,041 - 103,679,947 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049367035,744 - 45,636 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ECT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13111,248,131 - 111,314,828 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113111,248,215 - 111,310,746 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ECT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11516,612,738 - 16,685,455 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1516,612,443 - 16,685,386 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606325,373,942 - 25,446,633 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ect2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473050,773,566 - 50,840,510 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473050,773,465 - 50,841,427 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ect2
958 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:566
Count of miRNA genes:216
Interacting mature miRNAs:264
Transcripts:ENSRNOT00000018055, ENSRNOT00000067467
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)2105628029150628029Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)282947902127947902Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)284056790132859658Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)282214549127214549Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
7488933Bp368Blood pressure QTL 3680.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2104957381149957381Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
2317886Alcrsp23Alcohol response QTL 232.40.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)295142371140142371Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
2317058Aia13Adjuvant induced arthritis QTL 132.9joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)278269809123269809Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)244537979112567334Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2100807373145807373Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2106869825151869825Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)293602631145807373Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat

Markers in Region
BE117772  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22109,996,795 - 109,996,954 (+)MAPPERmRatBN7.2
Rnor_6.02112,790,367 - 112,790,525NCBIRnor6.0
Rnor_5.02132,511,029 - 132,511,187UniSTSRnor5.0
RGSC_v3.42112,990,242 - 112,990,400UniSTSRGSC3.4
Celera2105,209,027 - 105,209,185UniSTS
RH 3.4 Map2724.2UniSTS
Cytogenetic Map2q24UniSTS
RH140767  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera2105,188,240 - 105,188,378UniSTS
RH 3.4 Map2724.2UniSTS
Cytogenetic Map2q24UniSTS
AU049848  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22109,981,513 - 109,981,710 (+)MAPPERmRatBN7.2
Rnor_6.02112,775,086 - 112,775,282NCBIRnor6.0
Rnor_5.02132,495,748 - 132,495,944UniSTSRnor5.0
RGSC_v3.42112,974,961 - 112,975,157UniSTSRGSC3.4
Celera2105,193,740 - 105,193,942UniSTS
Cytogenetic Map2q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 66 164 91 90 59 85 59 6 347 184 11 143 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000018055   ⟹   ENSRNOP00000018055
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2111,904,522 - 111,966,626 (-)Ensembl
mRatBN7.2 Ensembl2109,975,813 - 110,037,911 (-)Ensembl
Rnor_6.0 Ensembl2112,769,385 - 112,831,476 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2111,904,522 - 111,966,626 (-)Ensembl
mRatBN7.2 Ensembl2109,975,813 - 110,031,386 (-)Ensembl
Rnor_6.0 Ensembl2112,770,443 - 112,831,443 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093010
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2109,975,816 - 110,033,146 (-)Ensembl
Rnor_6.0 Ensembl2112,770,417 - 112,831,383 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093081   ⟹   ENSRNOP00000076063
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2109,975,818 - 110,008,500 (-)Ensembl
Rnor_6.0 Ensembl2112,769,388 - 112,802,073 (-)Ensembl
RefSeq Acc Id: NM_001108547   ⟹   NP_001102017
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82111,904,522 - 111,966,626 (-)NCBI
mRatBN7.22109,975,813 - 110,037,911 (-)NCBI
Rnor_6.02112,769,385 - 112,831,476 (-)NCBI
Rnor_5.02132,490,047 - 132,552,138 (-)NCBI
RGSC_v3.42112,969,261 - 113,001,056 (-)RGD
Celera2105,188,023 - 105,250,067 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063282043   ⟹   XP_063138113
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82111,904,522 - 111,966,756 (-)NCBI
RefSeq Acc Id: XM_063282044   ⟹   XP_063138114
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82111,904,522 - 111,966,747 (-)NCBI
RefSeq Acc Id: XM_063282045   ⟹   XP_063138115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82111,904,522 - 111,966,367 (-)NCBI
RefSeq Acc Id: XM_063282046   ⟹   XP_063138116
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82111,904,522 - 111,966,747 (-)NCBI
RefSeq Acc Id: XM_063282047   ⟹   XP_063138117
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82111,904,522 - 111,966,786 (-)NCBI
RefSeq Acc Id: XM_063282048   ⟹   XP_063138118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82111,904,522 - 111,966,746 (-)NCBI
RefSeq Acc Id: XM_063282049   ⟹   XP_063138119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82111,904,522 - 111,966,746 (-)NCBI
RefSeq Acc Id: XM_063282050   ⟹   XP_063138120
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82111,904,522 - 111,966,746 (-)NCBI
RefSeq Acc Id: XR_010063624
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82111,927,998 - 111,966,749 (-)NCBI
RefSeq Acc Id: NP_001102017   ⟸   NM_001108547
- UniProtKB: D3ZUD0 (UniProtKB/TrEMBL),   A0A8I6GJ38 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018055   ⟸   ENSRNOT00000018055
Ensembl Acc Id: ENSRNOP00000076063   ⟸   ENSRNOT00000093081
RefSeq Acc Id: XP_063138117   ⟸   XM_063282047
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GJ38 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138113   ⟸   XM_063282043
- Peptide Label: isoform X1
- UniProtKB: D3ZUD0 (UniProtKB/TrEMBL),   A0A8I6GJ38 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138116   ⟸   XM_063282046
- Peptide Label: isoform X1
- UniProtKB: D3ZUD0 (UniProtKB/TrEMBL),   A0A8I6GJ38 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138114   ⟸   XM_063282044
- Peptide Label: isoform X1
- UniProtKB: D3ZUD0 (UniProtKB/TrEMBL),   A0A8I6GJ38 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138120   ⟸   XM_063282050
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GJ38 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138118   ⟸   XM_063282048
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GJ38 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138119   ⟸   XM_063282049
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GJ38 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138115   ⟸   XM_063282045
- Peptide Label: isoform X1
- UniProtKB: D3ZUD0 (UniProtKB/TrEMBL),   A0A8I6GJ38 (UniProtKB/TrEMBL)
Protein Domains
BRCT   DH   ECT2 PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZUD0-F1-model_v2 AlphaFold D3ZUD0 1-912 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691267
Promoter ID:EPDNEW_R1787
Type:multiple initiation site
Name:Ect2_1
Description:epithelial cell transforming 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02112,831,474 - 112,831,534EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308524 AgrOrtholog
BioCyc Gene G2FUF-53517 BioCyc
Ensembl Genes ENSRNOG00000024365 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018055 ENTREZGENE
  ENSRNOT00000018055.9 UniProtKB/TrEMBL
  ENSRNOT00000092855 ENTREZGENE
  ENSRNOT00000092855.2 UniProtKB/TrEMBL
  ENSRNOT00000093010.2 UniProtKB/TrEMBL
  ENSRNOT00000093081.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  3.40.50.10190 UniProtKB/TrEMBL
InterPro BRCT_dom UniProtKB/TrEMBL
  BRCT_dom_sf UniProtKB/TrEMBL
  DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  Ect2 UniProtKB/TrEMBL
  ECT2_BRCT0 UniProtKB/TrEMBL
  ECT2_PH UniProtKB/TrEMBL
  GDS_CDC24_CS UniProtKB/TrEMBL
  PH_like_dom UniProtKB/TrEMBL
KEGG Report rno:361921 UniProtKB/TrEMBL
NCBI Gene 361921 ENTREZGENE
PANTHER PROTEIN ECT2 UniProtKB/TrEMBL
  PTHR16777 UniProtKB/TrEMBL
Pfam BRCT UniProtKB/TrEMBL
  ECT2_BRCT0 UniProtKB/TrEMBL
  ECT2_PH UniProtKB/TrEMBL
  PTCB-BRCT UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
PhenoGen Ect2 PhenoGen
PROSITE BRCT UniProtKB/TrEMBL
  DH_1 UniProtKB/TrEMBL
  DH_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000024365 RatGTEx
SMART BRCT UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
Superfamily-SCOP BRCT UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
UniProt A0A1B0GWY1_RAT UniProtKB/TrEMBL
  A0A8I6AQ76_RAT UniProtKB/TrEMBL
  A0A8I6GJ38 ENTREZGENE, UniProtKB/TrEMBL
  B5DF83_RAT UniProtKB/TrEMBL
  D3ZUD0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-21 Ect2  epithelial cell transforming 2  Ect2  epithelial cell transforming sequence 2 oncogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-17 Ect2  epithelial cell transforming sequence 2 oncogene  Ect2  ect2 oncogene   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ect2  ect2 oncogene   Ect2_predicted  ect2 oncogene (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ect2_predicted  ect2 oncogene (predicted)      Symbol and Name status set to approved 70820 APPROVED