Cdc16 (cell division cycle 16) - Rat Genome Database

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Gene: Cdc16 (cell division cycle 16) Rattus norvegicus
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Symbol: Cdc16
Name: cell division cycle 16
RGD ID: 1305076
Description: Predicted to be involved in several processes, including anaphase-promoting complex-dependent catabolic process; protein K11-linked ubiquitination; and regulation of sister chromatid segregation. Predicted to be located in centrosome; mitotic spindle; and nucleus. Predicted to be part of anaphase-promoting complex. Predicted to be active in cytoplasm. Orthologous to human CDC16 (cell division cycle 16); PARTICIPATES IN cell cycle pathway, mitotic; ubiquitin/proteasome degradation pathway; INTERACTS WITH 1,3-dinitrobenzene; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CDC16 cell division cycle 16 homolog; CDC16 cell division cycle 16 homolog (S. cerevisiae); cell division cycle 16 homolog; cell division cycle 16 homolog (S. cerevisiae); cell division cycle protein 16 homolog; LOC290875
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21675,773,026 - 75,796,586 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1675,773,028 - 75,796,550 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1681,053,720 - 81,077,204 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01684,506,682 - 84,530,166 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01679,756,976 - 79,780,137 (-)NCBIRnor_WKY
Rnor_6.01681,493,355 - 81,516,493 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1681,493,355 - 81,516,493 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01680,981,546 - 81,004,585 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41680,628,131 - 80,650,925 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11680,628,395 - 80,651,190 (-)NCBI
Celera1673,581,950 - 73,604,842 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7736578   PMID:12477932   PMID:14744933   PMID:16364912   PMID:18485873   PMID:21926987  


Genomics

Comparative Map Data
Cdc16
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21675,773,026 - 75,796,586 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1675,773,028 - 75,796,550 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1681,053,720 - 81,077,204 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01684,506,682 - 84,530,166 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01679,756,976 - 79,780,137 (-)NCBIRnor_WKY
Rnor_6.01681,493,355 - 81,516,493 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1681,493,355 - 81,516,493 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01680,981,546 - 81,004,585 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41680,628,131 - 80,650,925 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11680,628,395 - 80,651,190 (-)NCBI
Celera1673,581,950 - 73,604,842 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
CDC16
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813114,234,897 - 114,272,723 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl13114,234,887 - 114,272,723 (+)EnsemblGRCh38hg38GRCh38
GRCh3713115,000,372 - 115,038,198 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3613114,018,464 - 114,056,252 (+)NCBINCBI36Build 36hg18NCBI36
Build 3413114,018,475 - 114,056,252NCBI
Celera1395,672,733 - 95,710,522 (+)NCBICelera
Cytogenetic Map13q34NCBI
HuRef1395,262,577 - 95,300,344 (+)NCBIHuRef
CHM1_113114,969,034 - 115,006,823 (+)NCBICHM1_1
T2T-CHM13v2.013113,443,956 - 113,481,783 (+)NCBIT2T-CHM13v2.0
Cdc16
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39813,807,650 - 13,831,951 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl813,807,676 - 13,831,938 (+)EnsemblGRCm39 Ensembl
GRCm38813,757,649 - 13,781,951 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl813,757,676 - 13,781,938 (+)EnsemblGRCm38mm10GRCm38
MGSCv37813,757,690 - 13,781,882 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36813,757,667 - 13,781,859 (+)NCBIMGSCv36mm8
Celera813,923,731 - 13,947,923 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
Cdc16
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540445,383 - 71,466 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540447,126 - 71,602 (-)NCBIChiLan1.0ChiLan1.0
CDC16
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.113114,369,774 - 114,407,267 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13114,369,774 - 114,407,267 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01395,300,763 - 95,340,762 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CDC16
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12261,283,263 - 61,312,283 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2261,283,309 - 61,312,283 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2260,994,906 - 61,023,919 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02261,970,375 - 61,999,261 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2261,970,404 - 62,000,439 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12261,407,802 - 61,436,819 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02261,416,165 - 61,444,982 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02261,443,393 - 61,472,197 (+)NCBIUU_Cfam_GSD_1.0
Cdc16
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945196,169,252 - 196,194,381 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004937030216,744 - 241,196 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004937030217,078 - 242,126 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDC16
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1179,084,182 - 79,115,268 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11179,084,243 - 79,111,758 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pig Cytomap11qNCBI
CDC16
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1392,018,619 - 92,057,232 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl392,018,681 - 92,059,413 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604649,312,946 - 49,352,029 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdc16
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624793151,508 - 186,342 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cdc16
133 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:47
Count of miRNA genes:43
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000023736
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat

Markers in Region
RH127667  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21675,773,257 - 75,773,466 (-)MAPPERmRatBN7.2
Rnor_6.01681,516,096 - 81,516,304NCBIRnor6.0
Rnor_5.01681,004,188 - 81,004,396UniSTSRnor5.0
RGSC_v3.41680,628,320 - 80,628,528UniSTSRGSC3.4
Celera1673,582,139 - 73,582,347UniSTS
RH 3.4 Map16743.9UniSTS
Cytogenetic Map16q12.5UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 57 41 19 41 8 11 74 35 41 11 8
Low 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000023736   ⟹   ENSRNOP00000023736
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1675,773,040 - 75,796,550 (-)Ensembl
Rnor_6.0 Ensembl1681,493,355 - 81,516,493 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000090674   ⟹   ENSRNOP00000068614
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1675,773,028 - 75,795,986 (-)Ensembl
Rnor_6.0 Ensembl1681,493,371 - 81,516,492 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092265
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1681,510,496 - 81,511,243 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092305
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1681,514,026 - 81,514,579 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092433
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1681,508,375 - 81,508,980 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092531
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1675,773,028 - 75,796,269 (-)Ensembl
Rnor_6.0 Ensembl1681,493,477 - 81,516,493 (+)Ensembl
RefSeq Acc Id: NM_001024744   ⟹   NP_001019915
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21675,773,069 - 75,796,557 (-)NCBI
Rnor_6.01681,493,355 - 81,516,493 (+)NCBI
Rnor_5.01680,981,546 - 81,004,585 (+)NCBI
RGSC_v3.41680,628,131 - 80,650,925 (-)RGD
Celera1673,581,950 - 73,604,842 (-)RGD
Sequence:
RefSeq Acc Id: XM_039094410   ⟹   XP_038950338
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21675,773,026 - 75,796,575 (-)NCBI
RefSeq Acc Id: XR_005494584
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21675,777,038 - 75,796,586 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001019915 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950338 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH97498 (Get FASTA)   NCBI Sequence Viewer  
  EDM08912 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001019915   ⟸   NM_001024744
- UniProtKB: Q4V884 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023736   ⟸   ENSRNOT00000023736
RefSeq Acc Id: ENSRNOP00000068614   ⟸   ENSRNOT00000090674
RefSeq Acc Id: XP_038950338   ⟸   XM_039094410
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4V884-F1-model_v2 AlphaFold Q4V884 1-620 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700227
Promoter ID:EPDNEW_R10751
Type:multiple initiation site
Name:Cdc16_1
Description:cell division cycle 16
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01681,493,346 - 81,493,406EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305076 AgrOrtholog
BioCyc Gene G2FUF-10732 BioCyc
Ensembl Genes ENSRNOG00000017536 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000023736 ENTREZGENE
  ENSRNOP00000023736.5 UniProtKB/TrEMBL
  ENSRNOP00000068614.2 UniProtKB/TrEMBL
  ENSRNOP00000092614.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023736 ENTREZGENE
  ENSRNOT00000023736.8 UniProtKB/TrEMBL
  ENSRNOT00000090674.2 UniProtKB/TrEMBL
  ENSRNOT00000092531.2 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7462333 IMAGE-MGC_LOAD
InterPro TPR-like_helical UniProtKB/TrEMBL
  TPR_repeat UniProtKB/TrEMBL
KEGG Report rno:290875 UniProtKB/TrEMBL
MGC_CLONE MGC:114573 IMAGE-MGC_LOAD
NCBI Gene 290875 ENTREZGENE
PhenoGen Cdc16 PhenoGen
PROSITE TPR UniProtKB/TrEMBL
SMART TPR UniProtKB/TrEMBL
Superfamily-SCOP SSF48452 UniProtKB/TrEMBL
UniProt A0A0G2JT88_RAT UniProtKB/TrEMBL
  A0A8I6AE10_RAT UniProtKB/TrEMBL
  Q4V884 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-31 Cdc16  cell division cycle 16  Cdc16  cell division cycle 16 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-20 Cdc16  cell division cycle 16 homolog (S. cerevisiae)  Cdc16  CDC16 cell division cycle 16 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Cdc16  CDC16 cell division cycle 16 homolog (S. cerevisiae)  Cdc16_predicted  CDC16 cell division cycle 16 homolog (S. cerevisiae) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Cdc16_predicted  CDC16 cell division cycle 16 homolog (S. cerevisiae) (predicted)      Symbol and Name status set to approved 70820 APPROVED