Aqp7 (aquaporin 7) - Rat Genome Database

Name: Aqp7
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Aqp7 (aquaporin 7) Rattus norvegicus

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Symbol:

Aqp7

Name:

aquaporin 7

RGD ID:

2145

Description:

Enables glycerol channel activity; urea channel activity; and water channel activity. Involved in several processes, including glycerol transmembrane transport; urea transport; and water transport. Located in brush border membrane. Part of ribonucleoprotein complex. Orthologous to several human genes including AQP7 (aquaporin 7); PARTICIPATES IN eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; water transport pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 3-chloropropane-1,2-diol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

AQP-7; aquaglyceroporin-7; aquaporin-7

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	AQP7 (aquaporin 7)	HGNC	EggNOG, Ensembl, HomoloGene, NCBI, OMA, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Aqp7 (aquaporin 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Aqp7 (aquaporin 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	AQP7 (aquaporin 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	AQP7 (aquaporin 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Aqp7 (aquaporin 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	AQP7 (aquaporin 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	AQP7 (aquaporin 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Aqp7 (aquaporin 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	AQP7B (aquaporin 7B)	HGNC	EggNOG, Ensembl, OrthoDB, Panther
Homo sapiens (human):	AQP7P3 (aquaporin 7 pseudogene 3)	HGNC	Inparanoid, PhylomeDB
Homo sapiens (human):	AQP7P3 (aquaporin 7 pseudogene 3)	HGNC	Panther
Alliance orthologs ³
Homo sapiens (human):	AQP7 (aquaporin 7)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Aqp7 (aquaporin 7)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	AQP7P3 (aquaporin 7 pseudogene 3)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	aqp7 (aquaporin 7)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	AQY3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	aqp-1	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	aqp-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	aqp-3	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	aqp-8	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	aqp7	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	60,968,495 - 60,982,618 (-)	NCBI		GRCr8
mRatBN7.2	5	56,171,649 - 56,186,642 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	56,172,519 - 56,186,642 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	58,138,736 - 58,152,556 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	59,957,884 - 59,971,702 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	59,952,637 - 59,966,600 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	57,358,297 - 57,372,332 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	57,358,327 - 57,372,239 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	61,888,637 - 61,902,549 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	58,433,731 - 58,447,853 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	58,433,909 - 58,448,032 (-)	NCBI
Celera	5	54,784,415 - 54,798,541 (-)	NCBI		Celera
Cytogenetic Map	5	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acromesomelic dysplasia, Maroteaux type (ISO)

colitis (ISO)

Crohn's disease (ISO)

distal arthrogryposis type 1A (ISO)

Experimental Liver Cirrhosis (ISO)

frontotemporal dementia and/or amyotrophic lateral sclerosis 6 (ISO)

galactosemia (ISO)

morbid obesity (ISO)

obesity (ISO)

primary ciliary dyskinesia (ISO)

type 2 diabetes mellitus (ISO)

ulcerative colitis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

(R)-adrenaline (ISO)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-hydroxypropanoic acid (ISO)

3-chloropropane-1,2-diol (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

acetamide (EXP)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

amphetamine (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bexarotene (EXP)

bisphenol A (EXP,ISO)

calcitriol (ISO)

chlorpyrifos (ISO)

choline (ISO)

cisplatin (ISO)

Citreoviridin (EXP,ISO)

clofibrate (EXP)

cyclosporin A (ISO)

dexamethasone (EXP,ISO)

diazinon (ISO)

dibenzofurans (ISO)

dimethylarsinic acid (EXP)

dipentyl phthalate (EXP)

diprotium oxide (EXP)

disodium selenite (EXP,ISO)

diuron (EXP)

doxorubicin (ISO)

endosulfan (EXP)

fenofibrate (EXP)

flavonoids (EXP)

flutamide (EXP)

folic acid (ISO)

furan (EXP)

genistein (ISO)

glycerol (EXP,ISO)

hydrogen cyanide (ISO)

indometacin (EXP,ISO)

L-methionine (ISO)

lycopene (ISO)

mercaptoethanol (ISO)

mercury dichloride (EXP,ISO)

metformin (EXP)

methylmercury chloride (EXP)

milrinone (EXP)

Muraglitazar (EXP)

N-nitrosodiethylamine (EXP,ISO)

N-nitrosodimethylamine (EXP)

N-Nitrosopyrrolidine (ISO)

nickel atom (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP)

phenformin (EXP)

phenobarbital (ISO)

Phenylamil (ISO)

pioglitazone (ISO)

pirinixic acid (EXP,ISO)

potassium cyanide (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

progesterone (EXP)

quercetin (EXP)

rac-lactic acid (ISO)

resveratrol (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

sodium fluoride (ISO)

streptozocin (EXP)

tamibarotene (ISO)

tamoxifen (EXP)

Tesaglitazar (EXP)

thiamine(1+) chloride (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

triclosan (ISO)

triphenyl phosphate (EXP)

triptonide (ISO)

troglitazone (EXP,ISO)

urea (EXP)

valproic acid (ISO)

vanadyl sulfate (EXP)

water (EXP)

zinc dichloride (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

glycerol transmembrane transport (IBA,IDA,ISO)

renal water absorption (ISO)

response to xenobiotic stimulus (IEP)

spermatogenesis (IEP)

urea transmembrane transport (IEA)

urea transport (IDA)

water transport (IBA,IDA,ISO,TAS)

Cellular Component

basolateral plasma membrane (IBA)

brush border membrane (IDA)

cell cortex (IEA)

cell-cell junction (ISO)

cytoplasm (ISO)

cytoplasmic vesicle membrane (IEA)

lipid droplet (ISO)

plasma membrane (IBA,ISO,ISS)

ribonucleoprotein complex (IDA)

Molecular Function

glycerol channel activity (IBA,IDA,ISO)

protein binding (ISO)

urea channel activity (IDA)

urea transmembrane transporter activity (IBA)

water channel activity (IBA,IDA,ISO,TAS)

Molecular Pathway Annotations Click to see Annotation Detail View

eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma (IEA)

water transport pathway (TAS)

References

References - curated

#	Reference Title	Reference Citation
1.	Possible involvement of aquaporin-7 and -8 in rat testis development and spermatogenesis.	Calamita G, etal., Biochem Biophys Res Commun 2001 Nov 2;288(3):619-25.
2.	Adipose tissue expression of the glycerol channel Aquaporin-7 gene is altered in severe obesity but not in Type 2 diabetes.	Ceperuelo-Mallafre V, etal., J Clin Endocrinol Metab. 2007 Jun 12;.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Aquaporin expression is downregulated in a murine model of colitis and in patients with ulcerative colitis, Crohn's disease and infectious colitis.	Hardin JA, etal., Cell Tissue Res. 2004 Nov;318(2):313-23. Epub 2004 Aug 27.
6.	Cellular localization of aquaporin 7 in the rat kidney.	Ishibashi K, etal., Exp Nephrol. 2000 Jul-Oct;8(4-5):252-7.
7.	Cloning and functional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol, and urea.	Ishibashi K, etal., J Biol Chem 1997 Aug 15;272(33):20782-6.
8.	Aquaporins in the kidney.	Kwon TH, etal., Handb Exp Pharmacol. 2009;(190):95-132. doi: 10.1007/978-3-540-79885-9_5.
9.	Increased AQP7 abundance in skeletal muscle from obese men with type 2 diabetes.	Lebeck J, etal., Am J Physiol Endocrinol Metab. 2018 Sep 1;315(3):E367-E373. doi: 10.1152/ajpendo.00468.2017. Epub 2018 May 21.
10.	The effects of thiazolidinedione treatment on the regulations of aquaglyceroporins and glycerol kinase in OLETF rats.	Lee DH, etal., Metabolism. 2005 Oct;54(10):1282-9.
11.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
12.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
13.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
14.	GOA pipeline	RGD automated data pipeline
15.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
16.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
17.	Immunohistochemical localization of a water channel, aquaporin 7 (AQP7), in the rat testis.	Suzuki-Toyota F, etal., Cell Tissue Res. 1999 Feb;295(2):279-85.
18.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:1373524	PMID:1510932	PMID:7530250	PMID:9369468	PMID:9405233	PMID:9806845	PMID:9829975	PMID:10318966	PMID:10510269	PMID:10564231	PMID:11001937	PMID:11034202
PMID:11076974	PMID:11573934	PMID:11952783	PMID:12084581	PMID:12192003	PMID:14701836	PMID:15489334	PMID:15595681	PMID:15943587	PMID:15948717	PMID:15998844	PMID:16596446
PMID:17178220	PMID:18059526	PMID:18202181	PMID:18501347	PMID:18511455	PMID:18718702	PMID:18762715	PMID:19180911	PMID:19585522	PMID:21251984	PMID:21321634	PMID:25643985
PMID:30420639	PMID:32735865	PMID:33506920	PMID:36834823

Genomics

Comparative Map Data

Aqp7
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	60,968,495 - 60,982,618 (-)	NCBI		GRCr8
mRatBN7.2	5	56,171,649 - 56,186,642 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	56,172,519 - 56,186,642 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	58,138,736 - 58,152,556 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	59,957,884 - 59,971,702 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	59,952,637 - 59,966,600 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	57,358,297 - 57,372,332 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	57,358,327 - 57,372,239 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	61,888,637 - 61,902,549 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	58,433,731 - 58,447,853 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	58,433,909 - 58,448,032 (-)	NCBI
Celera	5	54,784,415 - 54,798,541 (-)	NCBI		Celera
Cytogenetic Map	5	q22	NCBI

AQP7
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	33,383,191 - 33,402,568 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	33,383,179 - 33,402,682 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	33,383,189 - 33,402,566 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	33,374,948 - 33,392,517 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	33,374,947 - 33,392,517	NCBI
Celera	9	33,315,070 - 33,332,637 (-)	NCBI		Celera
Cytogenetic Map	9	p13.3	NCBI
HuRef	9	33,341,505 - 33,358,953 (-)	NCBI		HuRef
CHM1_1	9	33,384,744 - 33,402,308 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	33,401,795 - 33,421,171 (-)	NCBI		T2T-CHM13v2.0

Aqp7
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	41,033,074 - 41,048,237 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	41,033,074 - 41,048,139 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	41,033,074 - 41,048,237 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	41,033,074 - 41,048,139 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	40,980,107 - 40,995,169 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	41,221,748 - 41,236,641 (-)	NCBI		MGSCv36	mm8
Celera	4	40,693,722 - 40,709,136 (-)	NCBI		Celera
Cytogenetic Map	4	A5	NCBI
cM Map	4	20.83	NCBI

Aqp7
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955472	2,283,426 - 2,297,251 (+)	NCBI	ChiLan1.0	ChiLan1.0

AQP7
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	91,201,225 - 91,220,849 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	91,207,167 - 91,226,803 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	33,160,982 - 33,180,638 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	33,971,842 - 33,983,454 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

AQP7
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	50,474,007 - 50,488,191 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	49,104,054 - 49,118,284 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	51,414,635 - 51,428,870 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	51,413,367 - 51,428,758 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	50,078,662 - 50,092,894 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	49,945,887 - 49,960,128 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	50,710,993 - 50,725,230 (-)	NCBI		UU_Cfam_GSD_1.0

Aqp7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	165,351,053 - 165,367,563 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936524	1,898,635 - 1,915,078 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AQP7
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	10	33,098,746 - 33,130,245 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	37,361,028 - 37,376,629 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AQP7
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	46,866,519 - 46,886,525 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666038	43,758,462 - 43,777,506 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Aqp7
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624736	38,130,992 - 38,148,444 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Aqp7
108 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	17
Count of miRNA genes:	17
Interacting mature miRNAs:	17
Transcripts:	ENSRNOT00000012975
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578776	Stresp18	Stress response QTL 18	2.9		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	5	27955440	72955440	Rat
1298067	Scl15	Serum cholesterol level QTL 15	4.8	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	33215665	78215665	Rat
1300115	Hrtrt7	Heart rate QTL 7	2.76		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	5	47869062	90099692	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	40128307	148607290	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	1	131345958	Rat
1358353	Srcrtb2	Stress Responsive Cort Basal QTL 2	3.48	0.003	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	18873947	74251464	Rat
634305	Mamtr1	Mammary tumor resistance QTL 1		0.0001	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	12789751	113558310	Rat
1331801	Rf33	Renal function QTL 33	4.149		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	43726656	129132602	Rat
1598807	Glom12	Glomerulus QTL 12	2.7		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	5	33215665	78215665	Rat
1302786	Kidm8	Kidney mass QTL 8	28.15		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	5	33215665	78215665	Rat
6903292	Stl28	Serum triglyceride level QTL 28	2.6	0.0073	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	5	28515489	73515489	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	46711509	161317411	Rat
1578767	Stresp17	Stress response QTL 17	4.3	0.01	blood aldosterone amount (VT:0005346)	plasma aldosterone level (CMO:0000551)	5	27955440	72955440	Rat
7411561	Bw134	Body weight QTL 134	24	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	49463600	94463600	Rat
1641922	Alcrsp8	Alcohol response QTL 8			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	5	35189153	68564008	Rat
2303615	Vencon7	Ventilatory control QTL 7		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	5	50983895	95983895	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	50328551	141643988	Rat
1641912	Alcrsp18	Alcohol response QTL 18			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	35189153	141643988	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
6903306	Scl35	Serum cholesterol QTL 35	2.6	0.0073	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	28515489	73515489	Rat
1576317	Eutr2	Estrogen induced uterine response QTL 2		0.01	uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	34730116	104251008	Rat
7394712	Emca13	Estrogen-induced mammary cancer QTL 13			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	9823266	99753708	Rat
1331773	Scl26	Serum cholesterol level QTL 26	3.065		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	43726656	86724018	Rat
70189	Mcs5	Mammary carcinoma susceptibility QTL 5	10.51		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55805606	132207589	Rat
1331771	Rf35	Renal function QTL 35	4.36965		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	729470	86724018	Rat
61359	Eaex	Experimental allergic encephalomyelitis QTL x	3		nervous system integrity trait (VT:0010566)	post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)	5	55715622	100715622	Rat
8662454	Vetf3	Vascular elastic tissue fragility QTL 3	27.4		artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	5	2282226	69540447	Rat
2290448	Scl54	Serum cholesterol level QTL 54	2.93		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	31663789	131345958	Rat
9589025	Epfw7	Epididymal fat weight QTL 7	20.66	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	5	49463600	94463600	Rat
2303574	Gluco42	Glucose level QTL 42	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	53496719	98496719	Rat
1641903	Alcrsp3	Alcohol response QTL 3			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	12689285	57689285	Rat
1331756	Rf34	Renal function QTL 34	4.16275		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	1	90450412	Rat
8552954	Pigfal14	Plasma insulin-like growth factor 1 level QTL 14	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	21226744	66226744	Rat
2316959	Gluco59	Glucose level QTL 59	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	34944474	113558310	Rat
1600358	Mamtr5	Mammary tumor resistance QTL 5			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	18873947	63873947	Rat

Markers in Region

RH133701

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	56,172,545 - 56,172,737 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	57,358,354 - 57,358,545	NCBI	Rnor6.0
Rnor_5.0	5	61,888,664 - 61,888,855	UniSTS	Rnor5.0
RGSC_v3.4	5	58,433,758 - 58,433,949	UniSTS	RGSC3.4
Celera	5	54,784,442 - 54,784,633	UniSTS
Cytogenetic Map	5	q22	UniSTS

RH142180

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	56,172,526 - 56,172,699 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	57,358,335 - 57,358,507	NCBI	Rnor6.0
Rnor_5.0	5	61,888,645 - 61,888,817	UniSTS	Rnor5.0
RGSC_v3.4	5	58,433,739 - 58,433,911	UniSTS	RGSC3.4
Celera	5	54,784,423 - 54,784,595	UniSTS
Cytogenetic Map	5	q22	UniSTS

Aqp7

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	5	57,359,094 - 57,360,228	NCBI	Rnor6.0
Rnor_5.0	5	61,889,404 - 61,890,538	UniSTS	Rnor5.0
RGSC_v3.4	5	58,434,498 - 58,435,842	UniSTS	RGSC3.4
Celera	5	54,785,182 - 54,786,526	UniSTS
Cytogenetic Map	5	q22	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	60	90	87	58	23	58	6	215	95	40	45	58	29

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001429387	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001429388	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001429389	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001429390	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001429391	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001429392	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001429393	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_019157	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017593195	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109352	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB000507	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY120935	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY157737	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC072695	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473962	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000012975 ⟹ ENSRNOP00000012974

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	56,172,519 - 56,186,642 (-)	Ensembl
Rnor_6.0 Ensembl	5	57,358,327 - 57,372,239 (-)	Ensembl

RefSeq Acc Id:

NM_019157 ⟹ NP_062030

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	60,968,496 - 60,982,618 (-)	NCBI
mRatBN7.2	5	56,172,519 - 56,186,642 (-)	NCBI
Rnor_6.0	5	57,358,327 - 57,372,239 (-)	NCBI
Rnor_5.0	5	61,888,637 - 61,902,549 (-)	NCBI
RGSC_v3.4	5	58,433,731 - 58,447,853 (-)	RGD
Celera	5	54,784,415 - 54,798,541 (-)	RGD

Sequence:

show sequence

GCCAAACCCCTGCCCTACTGACCTCTCCCCTAGAGGAGCACAAGGGGACTCACAGCCGCCCTGG
GCAAGAGGCAGGCTCTGAGTGAGGACTTAGAGACTGCAGAGCCTCAGTTCAGTTACAGCTTGAG
CCTGCCGCAGTAATGGAGGACCAGAAACAAGATTATCTGTGATACTGACAGAGGGGCTGTGAGA
CAAGGCTAAAAAACAGAGCAGTCACTTCAGCAGAGTGAGCAGGGCTGCAGGTCCACCCACAATT
CCACAATGGCCGGTTCTGTGCTGGAGAACATACAATCAGTGCTACAGAAGACTTGGGTGCGTGA
GTTCCTGGCGGAGTTCCTGAGTACCTATGTCTTGATGGTGTTTGGCCTTGGTTCCGTGGCTCAT
ATGGTTCTAGGAGAAAGGCTTGGCAGCTATCTTGGTGTCAACTTGGGTTTTGGTTTCGGAGTGA
CCATGGGAATACATGTGGCAGGCGGCATCTCTGGAGCCCACATGAACGCCGCGGTGACTTTCAC
TAACTGTGCACTAGGCCGAATGGCCTGGAAGAAGTTCCCTATATATGTGCTGGGTCAGTTCCTG
GGTTCCTTCTTAGCTGCAGCTACCACCTACTTAATTTTCTATGGTGCCATTAACCACTATGCAG
GTGGAGAACTGTTGGTGACAGGTCCCAAATCCACTGCAAACATTTTTGCCACCTATCTTCCTGA
ACACATGACGCTGTGGCGGGGCTTCGTGGATGAGGTATTTGTGACTGGGATGCTCCAGCTGTGT
ATCTTCGCCATCACGGACAAGTTGAACAGTCCAGCACTTCAAGGGACCGAGCCCCTCATGATAG
GCATCCTTGTTTGCGTTCTTGGGGTGTCCCTAGGCATGAACACAGGATATGCAATCAACCCATC
CCGTGACCTGCCTCCCCGGTTCTTCACTTTCATTGCTGGCTGGGGCAAGAAAGTGTTCAGTGCC
GGGAACAACTGGTGGTGGGTGCCGGTGGTGGCACCCCTTCTGGGTGCCTACTTAGGTGGCATTG
TATACCTGGGCTTAATTCACGCCGGCATACCACCACAGGGTTCTTAGAGATTGGAGAATTGTAC
AACAGGAGACCAGAAGACGACAGCATCGTCCAACGATCCCCTCACCCCATCTCTTCTCCTCCAA
CTTCTGCGAAACCTACCCTACCCATAAGTGGTTCTGTGCCTCTAGCTTCTAGAGTACTTCTTAG
TAGAGCTTGTCTGTGACCACAACCCTTCTGCAATAAAGCACACCTCATACC

hide sequence

RefSeq Acc Id:

XM_039109352 ⟹ XP_038965280

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	60,968,495 - 60,980,935 (-)	NCBI
mRatBN7.2	5	56,171,649 - 56,184,699 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001416316	(Get FASTA)	NCBI Sequence Viewer
	NP_001416317	(Get FASTA)	NCBI Sequence Viewer
	NP_001416318	(Get FASTA)	NCBI Sequence Viewer
	NP_001416319	(Get FASTA)	NCBI Sequence Viewer
	NP_001416320	(Get FASTA)	NCBI Sequence Viewer
	NP_001416321	(Get FASTA)	NCBI Sequence Viewer
	NP_001416322	(Get FASTA)	NCBI Sequence Viewer
	NP_062030	(Get FASTA)	NCBI Sequence Viewer
	XP_038965280	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH72695	(Get FASTA)	NCBI Sequence Viewer
	AAM81581	(Get FASTA)	NCBI Sequence Viewer
	AAN52930	(Get FASTA)	NCBI Sequence Viewer
	BAA22053	(Get FASTA)	NCBI Sequence Viewer
	EDL98653	(Get FASTA)	NCBI Sequence Viewer
	EDL98654	(Get FASTA)	NCBI Sequence Viewer
	EDL98655	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000012974.1
GenBank Protein	P56403	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_062030 ⟸ NM_019157

- UniProtKB:

Q8K3F5 (UniProtKB/Swiss-Prot), P56403 (UniProtKB/Swiss-Prot), A6IIT3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAGSVLENIQSVLQKTWVREFLAEFLSTYVLMVFGLGSVAHMVLGERLGSYLGVNLGFGFGVTM
GIHVAGGISGAHMNAAVTFTNCALGRMAWKKFPIYVLGQFLGSFLAAATTYLIFYGAINHYAGG
ELLVTGPKSTANIFATYLPEHMTLWRGFVDEVFVTGMLQLCIFAITDKLNSPALQGTEPLMIGI
LVCVLGVSLGMNTGYAINPSRDLPPRFFTFIAGWGKKVFSAGNNWWWVPVVAPLLGAYLGGIVY
LGLIHAGIPPQGS

hide sequence

Ensembl Acc Id:

ENSRNOP00000012974 ⟸ ENSRNOT00000012975

RefSeq Acc Id:	XP_038965280 ⟸ XM_039109352
- Peptide Label:	isoform X1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P56403-F1-model_v2	AlphaFold	P56403	1-269	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693642

Promoter ID:

EPDNEW_R4166

Type:

initiation region

Name:

Aqp7_1

Description:

aquaporin 7

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	57,372,270 - 57,372,330	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2145	AgrOrtholog
BioCyc Gene	G2FUF-41581	BioCyc
Ensembl Genes	ENSRNOG00000009686	Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000012975.3	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.1080.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7104684	IMAGE-MGC_LOAD
InterPro	Aquaporin-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MIP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MIP/Aquaporin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:29171	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:91424	IMAGE-MGC_LOAD
NCBI Gene	29171	ENTREZGENE
PANTHER	AQUAPORIN OR AQUAGLYCEROPORIN RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	AQUAPORIN-7	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
Pfam	MIP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Aqp7	PhenoGen
PRINTS	AQUAPORIN7	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MINTRINSICP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000009686	RatGTEx
Superfamily-SCOP	Aquaporin-like	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR	TC207921
UniProt	A6IIT3	ENTREZGENE, UniProtKB/TrEMBL
	A6IIT4_RAT	UniProtKB/TrEMBL
	A6IIT5_RAT	UniProtKB/TrEMBL
	AQP7_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q8K3F5	ENTREZGENE
UniProt Secondary	Q8K3F5	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-06-10	Aqp7	aquaporin 7			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in testis at postnatal day 45, expression increases through day 90 and remains high in the adult	634665
gene_function	forms an aquaporin water channel	634665
gene_process	may play a role in regulation of fluid homeostasis during testis development and spermatogenesis	634665

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)