Sbk1 (SH3 domain binding kinase 1) - Rat Genome Database

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Gene: Sbk1 (SH3 domain binding kinase 1) Rattus norvegicus
Analyze
Symbol: Sbk1
Name: SH3 domain binding kinase 1
RGD ID: 628713
Description: Enables protein serine/threonine kinase activity. Involved in peptidyl-serine phosphorylation and peptidyl-threonine phosphorylation. Predicted to be located in cytoplasm. Orthologous to human SBK1 (SH3 domain binding kinase 1); INTERACTS WITH (+)-schisandrin B; 2,2',4,4'-Tetrabromodiphenyl ether; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC103690016; Sbk; serine/threonine-protein kinase SBK1; SH3-binding domain kinase 1; SH3-binding kinase; SH3-binding kinase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81190,237,677 - 190,282,494 (+)NCBIGRCr8
mRatBN7.21180,807,092 - 180,851,910 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,807,099 - 180,851,885 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,161,138 - 189,183,032 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01196,347,182 - 196,369,076 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01189,030,397 - 189,052,249 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01197,636,230 - 197,681,031 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1197,659,187 - 197,681,006 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl167,368,384 - 67,390,141 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01204,642,224 - 204,663,697 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0168,159,190 - 68,181,072 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,344,267 - 185,366,109 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11185,494,435 - 185,513,696 (+)NCBI
Celera1178,490,794 - 178,512,689 (+)NCBICelera
Cytogenetic Map1q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Cloning and characterization of a novel serine/threonine protein kinase gene expressed predominantly in developing brain. Nara K, etal., Eur J Biochem 2001 May;268(9):2642-51.
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Information Derived from GenBank Report RGD, Sept. 2003
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Sbk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81190,237,677 - 190,282,494 (+)NCBIGRCr8
mRatBN7.21180,807,092 - 180,851,910 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,807,099 - 180,851,885 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,161,138 - 189,183,032 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01196,347,182 - 196,369,076 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01189,030,397 - 189,052,249 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01197,636,230 - 197,681,031 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1197,659,187 - 197,681,006 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl167,368,384 - 67,390,141 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01204,642,224 - 204,663,697 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0168,159,190 - 68,181,072 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,344,267 - 185,366,109 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11185,494,435 - 185,513,696 (+)NCBI
Celera1178,490,794 - 178,512,689 (+)NCBICelera
Cytogenetic Map1q36NCBI
SBK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381628,258,681 - 28,323,849 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1628,259,246 - 28,323,849 (+)EnsemblGRCh38hg38GRCh38
GRCh371628,303,846 - 28,335,170 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361628,211,341 - 28,242,671 (+)NCBINCBI36Build 36hg18NCBI36
Celera1627,083,689 - 27,113,061 (+)NCBICelera
Cytogenetic Map16p12.1NCBI
HuRef1626,395,062 - 26,426,094 (+)NCBIHuRef
CHM1_11629,316,869 - 29,348,171 (+)NCBICHM1_1
T2T-CHM13v2.01628,539,191 - 28,604,353 (+)NCBIT2T-CHM13v2.0
Sbk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397125,847,524 - 125,894,188 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7125,848,034 - 125,894,188 (+)EnsemblGRCm39 Ensembl
GRCm387126,248,397 - 126,295,016 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7126,248,862 - 126,295,016 (+)EnsemblGRCm38mm10GRCm38
MGSCv377133,416,133 - 133,438,513 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367126,063,767 - 126,086,147 (+)NCBIMGSCv36mm8
Celera7126,125,641 - 126,148,522 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.01NCBI
Sbk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554936,383,626 - 6,394,919 (+)NCBIChiLan1.0ChiLan1.0
SBK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21829,657,487 - 29,722,585 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11634,194,166 - 34,259,258 (+)NCBINHGRI_mPanPan1
PanPan1.11628,627,718 - 28,692,677 (+)NCBIpanpan1.1PanPan1.1panPan2
SBK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1618,492,216 - 18,516,016 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl618,493,983 - 18,541,421 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha620,070,798 - 20,119,027 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0618,628,581 - 18,676,631 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl618,627,581 - 18,674,789 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1618,428,286 - 18,476,312 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0618,343,061 - 18,364,320 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0618,659,515 - 18,707,542 (-)NCBIUU_Cfam_GSD_1.0
Sbk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344123,608,864 - 123,632,455 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650111,706,718 - 11,730,358 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650111,706,724 - 11,730,315 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SBK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl318,676,246 - 18,732,465 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1318,674,566 - 18,732,853 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2318,861,170 - 18,867,826 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SBK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1525,955,778 - 26,021,391 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl526,014,121 - 26,018,252 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660683,608,288 - 3,723,160 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sbk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478212,710,189 - 12,755,835 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478212,710,237 - 12,758,359 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sbk1
342 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:271
Count of miRNA genes:180
Interacting mature miRNAs:203
Transcripts:ENSRNOT00000025808
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
61326Eae6Experimental allergic encephalomyelitis QTL 65.3body mass (VT:0001259)change in body weight (CMO:0002045)1172949660181830018Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1123556856242907031Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1117917486196963478Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1164747558181133855Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1166532971191278129Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1123556856196963478Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1178810256180814005Rat
2325725Eae31Experimental allergic encephalomyelitis QTL 31nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1178810256188377506Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1174133260196383668Rat


Expression

RNA-SEQ Expression

appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
5 8 76 20 13 4 16 4 48 33 68 7 20 9

Sequence


Ensembl Acc Id: ENSRNOT00000025808   ⟹   ENSRNOP00000025808
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1180,807,099 - 180,851,885 (+)Ensembl
Rnor_6.0 Ensembl167,368,384 - 67,390,141 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082228   ⟹   ENSRNOP00000073472
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1180,830,066 - 180,851,885 (+)Ensembl
Rnor_6.0 Ensembl1197,659,187 - 197,681,006 (+)Ensembl
RefSeq Acc Id: NM_147135   ⟹   NP_671476
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,260,652 - 190,282,494 (+)NCBI
mRatBN7.21180,830,066 - 180,851,908 (+)NCBI
Rnor_6.01197,659,187 - 197,681,029 (+)NCBI
Rnor_5.01204,642,224 - 204,663,697 (+)NCBI
RGSC_v3.41185,344,267 - 185,366,109 (+)RGD
Celera1178,490,794 - 178,512,689 (+)RGD
Sequence:
RefSeq Acc Id: XM_017588642   ⟹   XP_017444131
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,237,677 - 190,282,493 (+)NCBI
mRatBN7.21180,807,092 - 180,851,910 (+)NCBI
Rnor_6.01197,636,230 - 197,681,031 (+)NCBI
Sequence:
RefSeq Acc Id: NP_671476   ⟸   NM_147135
- UniProtKB: A2RRT7 (UniProtKB/Swiss-Prot),   Q9Z335 (UniProtKB/Swiss-Prot),   A6I937 (UniProtKB/TrEMBL),   A0A8L2QDW4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444131   ⟸   XM_017588642
- Peptide Label: isoform X1
- UniProtKB: A2RRT7 (UniProtKB/Swiss-Prot),   Q9Z335 (UniProtKB/Swiss-Prot),   A6I937 (UniProtKB/TrEMBL),   A0A8L2QDW4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073472   ⟸   ENSRNOT00000082228
Ensembl Acc Id: ENSRNOP00000025808   ⟸   ENSRNOT00000025808
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z335-F1-model_v2 AlphaFold Q9Z335 1-417 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690395
Promoter ID:EPDNEW_R918
Type:initiation region
Name:LOC103690016_1
Description:serine/threonine-protein kinase SBK1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01197,659,141 - 197,659,201EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628713 AgrOrtholog
BioCyc Gene G2FUF-57461 BioCyc
Ensembl Genes ENSRNOG00000019082 Ensembl
  ENSRNOG00000057696 Ensembl
  ENSRNOG00000067387 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055030950 UniProtKB/Swiss-Prot
  ENSRNOG00060027712 UniProtKB/Swiss-Prot
  ENSRNOG00065016268 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025808.6 UniProtKB/TrEMBL
  ENSRNOT00000082228.2 UniProtKB/Swiss-Prot
  ENSRNOT00055053693 UniProtKB/Swiss-Prot
  ENSRNOT00060048082 UniProtKB/Swiss-Prot
  ENSRNOT00065027071 UniProtKB/Swiss-Prot
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8363395 IMAGE-MGC_LOAD
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_Sbk1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:113907 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:156586 IMAGE-MGC_LOAD
NCBI Gene 113907 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE SBK1 UniProtKB/Swiss-Prot
  SERINE/THREONINE-PROTEIN KINASE SBK1 UniProtKB/Swiss-Prot
  SERINE/THREONINE-PROTEIN KINASE SBK1 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE SBK1 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sbk1 PhenoGen
PIRSF Ser/Thr_PK_Sbk1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019082 RatGTEx
  ENSRNOG00000057696 RatGTEx
  ENSRNOG00000067387 RatGTEx
  ENSRNOG00055030950 RatGTEx
  ENSRNOG00060027712 RatGTEx
  ENSRNOG00065016268 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2QDW4 ENTREZGENE, UniProtKB/TrEMBL
  A2RRT7 ENTREZGENE
  A6I937 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z335 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A2RRT7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Sbk1  SH3 domain binding kinase 1  LOC103690016  serine/threonine-protein kinase SBK1  Data merged from RGD:9439246 737654 PROVISIONAL
2014-08-25 LOC103690016  serine/threonine-protein kinase SBK1      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-11-11 Sbk1  SH3 domain binding kinase 1  Sbk1  SH3-binding domain kinase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Sbk1  SH3-binding domain kinase 1  Sbk1  SH3-binding kinase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Sbk1  SH3-binding kinase 1      Symbol and Name updated 1299863 APPROVED
2005-01-20 Sbk  SH3-binding kinase      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Sbk        Symbol and Name status set to provisional 70820 PROVISIONAL