Pias2 (protein inhibitor of activated STAT, 2) - Rat Genome Database

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Gene: Pias2 (protein inhibitor of activated STAT, 2) Rattus norvegicus
Analyze
Symbol: Pias2
Name: protein inhibitor of activated STAT, 2
RGD ID: 71056
Description: Enables nuclear receptor binding activity and protein domain specific binding activity. Involved in several processes, including androgen receptor signaling pathway; positive regulation of dendrite morphogenesis; and response to testosterone. Acts upstream of or within regulation of androgen receptor signaling pathway. Located in nucleus. Orthologous to human PIAS2 (protein inhibitor of activated STAT 2); PARTICIPATES IN androgen signaling pathway; Jak-Stat signaling pathway; hepatitis C pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; bisphenol A; finasteride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: androgen receptor-interacting protein 3; ARIP3; DAB2-interacting protein; DIP; E3 SUMO-protein ligase PIAS2; E3 SUMO-protein transferase PIAS2; Miz1; Msx-interacting-zinc finger; protein inhibitor of activated STAT 2; protein inhibitor of activated STAT x
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21870,608,034 - 70,714,295 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1870,607,665 - 70,710,033 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1872,729,105 - 72,813,704 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01873,398,313 - 73,482,913 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01871,254,907 - 71,339,508 (+)NCBIRnor_WKY
Rnor_6.01873,479,863 - 73,524,956 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1873,378,662 - 73,524,956 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01873,147,273 - 73,203,947 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41874,078,683 - 74,123,668 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11874,151,955 - 74,196,941 (+)NCBI
Celera1869,148,881 - 69,219,197 (+)NCBICelera
Cytogenetic Map18q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nuclear body  (ISO)
nuclear speck  (IEA)
nucleoplasm  (ISO)
nucleus  (IDA,IEA,ISO)
PML body  (ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Tollip is a mediator of protein sumoylation. Ciarrocchi A, etal., PLoS One. 2009;4(2):e4404. Epub 2009 Feb 9.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation. Kotaja N, etal., Mol Endocrinol. 2000 Dec;14(12):1986-2000.
4. Gene Data Set MGD Curation, June 12, 2002
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. A testis-specific androgen receptor coregulator that belongs to a novel family of nuclear proteins. Moilanen AM, etal., J Biol Chem 1999 Feb 5;274(6):3700-4.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. PIASx is a MEF2 SUMO E3 ligase that promotes postsynaptic dendritic morphogenesis. Shalizi A, etal., J Neurosci. 2007 Sep 12;27(37):10037-46.
13. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
14. Pias1 interaction and sumoylation of metabotropic glutamate receptor 8. Tang Z, etal., J Biol Chem. 2005 Nov 18;280(46):38153-9. Epub 2005 Sep 6.
15. JAK/STAT signal transduction: regulators and implication in hematological malignancies. Valentino L and Pierre J, Biochem Pharmacol. 2006 Mar 14;71(6):713-21. Epub 2006 Jan 19.
16. Expression of the E3 SUMO-1 ligases PIASx and PIAS1 during spermatogenesis in the rat. Yan W, etal., Gene Expr Patterns. 2003 Jun;3(3):301-8.
Additional References at PubMed
PMID:9256341   PMID:11104669   PMID:11477070   PMID:11893729   PMID:12077349   PMID:12855578   PMID:14752048   PMID:15489334   PMID:15767674   PMID:16352593   PMID:16522640   PMID:16675951  
PMID:16777850   PMID:16816390   PMID:17283066   PMID:17623776   PMID:18579533   PMID:18628979   PMID:20408817   PMID:21630459   PMID:22082260   PMID:22406621   PMID:23145142   PMID:26175529  
PMID:26581215   PMID:34947973  


Genomics

Comparative Map Data
Pias2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21870,608,034 - 70,714,295 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1870,607,665 - 70,710,033 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1872,729,105 - 72,813,704 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01873,398,313 - 73,482,913 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01871,254,907 - 71,339,508 (+)NCBIRnor_WKY
Rnor_6.01873,479,863 - 73,524,956 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1873,378,662 - 73,524,956 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01873,147,273 - 73,203,947 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41874,078,683 - 74,123,668 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11874,151,955 - 74,196,941 (+)NCBI
Celera1869,148,881 - 69,219,197 (+)NCBICelera
Cytogenetic Map18q12.3NCBI
PIAS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381846,803,218 - 46,920,145 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1846,803,218 - 46,920,160 (-)EnsemblGRCh38hg38GRCh38
GRCh371844,383,181 - 44,500,108 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361842,646,058 - 42,751,464 (-)NCBINCBI36Build 36hg18NCBI36
Celera1841,199,736 - 41,278,688 (-)NCBICelera
Cytogenetic Map18q21.1NCBI
HuRef1841,247,384 - 41,354,863 (-)NCBIHuRef
CHM1_11844,317,116 - 44,424,599 (-)NCBICHM1_1
T2T-CHM13v2.01846,993,864 - 47,110,811 (-)NCBIT2T-CHM13v2.0
Pias2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391877,152,883 - 77,243,406 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1877,152,904 - 77,241,496 (+)EnsemblGRCm39 Ensembl
GRCm381877,065,176 - 77,155,710 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1877,065,208 - 77,153,800 (+)EnsemblGRCm38mm10GRCm38
MGSCv371877,303,947 - 77,394,447 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361877,269,658 - 77,358,250 (+)NCBIMGSCv36mm8
Celera1878,248,789 - 78,338,301 (+)NCBICelera
Cytogenetic Map18E3NCBI
Pias2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540232,270,348 - 32,358,312 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540232,263,616 - 32,358,532 (-)NCBIChiLan1.0ChiLan1.0
PIAS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11843,622,455 - 43,728,675 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1843,622,455 - 43,728,675 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01840,067,901 - 40,196,078 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PIAS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1744,436,100 - 44,583,657 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl744,454,095 - 44,583,657 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha743,919,876 - 44,074,373 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0744,389,023 - 44,544,213 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl744,407,125 - 44,536,625 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1744,089,020 - 44,244,180 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0744,143,064 - 44,298,190 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0744,426,838 - 44,581,948 (+)NCBIUU_Cfam_GSD_1.0
Pias2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494440,745,308 - 40,828,055 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651782,332 - 144,586 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493651772,676 - 152,926 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIAS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl196,441,676 - 96,545,780 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1196,401,635 - 96,545,798 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PIAS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11833,967,894 - 34,075,824 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1833,967,999 - 34,067,910 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660508,306,725 - 8,446,143 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pias2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477810,434,550 - 10,530,766 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477810,426,788 - 10,530,854 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pias2
134 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:160
Count of miRNA genes:125
Interacting mature miRNAs:139
Transcripts:ENSRNOT00000023886
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184664067583828827Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185146473383218561Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185229287573997283Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)185253976376104388Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)185253976376104388Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)185253976376104388Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)185253976376104388Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)185253976376104388Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)185253976376104388Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185253976376104388Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)185470976983828827Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)185917211583828827Rat
2301969Bp324Blood pressure QTL 3244.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)185971241776477814Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647871893566Rat
6903353Bp353Blood pressure QTL 3532.8arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)185979647883828827Rat
6903356Bp354Blood pressure QTL 3544.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647883828827Rat
61384Bp48Blood pressure QTL 4819.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186062231177209844Rat
631675Iddm15Insulin dependent diabetes mellitus QTL 15urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)186062231177209844Rat

Markers in Region
RH142489  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21870,687,279 - 70,687,454 (+)MAPPERmRatBN7.2
Rnor_6.01873,514,926 - 73,515,100NCBIRnor6.0
Rnor_5.01873,182,346 - 73,182,520UniSTSRnor5.0
RGSC_v3.41874,113,747 - 74,113,921UniSTSRGSC3.4
Celera1869,209,257 - 69,209,431UniSTS
RH 3.4 Map18747.0UniSTS
Cytogenetic Map18q12.3UniSTS
RH143406  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21870,687,846 - 70,687,946 (+)MAPPERmRatBN7.2
Rnor_6.01873,515,493 - 73,515,592NCBIRnor6.0
Rnor_5.01873,182,913 - 73,183,012UniSTSRnor5.0
RGSC_v3.41874,114,314 - 74,114,413UniSTSRGSC3.4
Celera1869,209,824 - 69,209,923UniSTS
RH 3.4 Map18748.5UniSTS
Cytogenetic Map18q12.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001393764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_053337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC139391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF044058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC078775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000023886   ⟹   ENSRNOP00000023886
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1870,626,661 - 70,703,964 (+)Ensembl
Rnor_6.0 Ensembl1873,378,662 - 73,524,956 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101274   ⟹   ENSRNOP00000097965
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1870,626,522 - 70,702,066 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000104069   ⟹   ENSRNOP00000092568
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1870,650,408 - 70,697,322 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107723   ⟹   ENSRNOP00000092581
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1870,626,837 - 70,703,977 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110007   ⟹   ENSRNOP00000086650
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1870,607,665 - 70,703,977 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119543   ⟹   ENSRNOP00000097087
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1870,626,522 - 70,710,033 (+)Ensembl
RefSeq Acc Id: NM_053337   ⟹   NP_445789
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21870,626,573 - 70,697,310 (+)NCBI
Rnor_6.01873,479,863 - 73,524,956 (+)NCBI
Rnor_5.01873,147,273 - 73,203,947 (+)NCBI
RGSC_v3.41874,078,683 - 74,123,668 (+)RGD
Celera1869,148,881 - 69,219,197 (+)RGD
Sequence:
RefSeq Acc Id: XM_039097142   ⟹   XP_038953070
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21870,619,281 - 70,707,414 (+)NCBI
RefSeq Acc Id: XM_039097143   ⟹   XP_038953071
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21870,619,281 - 70,707,414 (+)NCBI
RefSeq Acc Id: XM_039097144   ⟹   XP_038953072
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21870,608,034 - 70,707,414 (+)NCBI
RefSeq Acc Id: XM_039097145   ⟹   XP_038953073
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21870,619,281 - 70,699,490 (+)NCBI
RefSeq Acc Id: XM_039097146   ⟹   XP_038953074
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21870,619,281 - 70,714,295 (+)NCBI
RefSeq Acc Id: XM_039097147   ⟹   XP_038953075
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21870,625,934 - 70,707,414 (+)NCBI
RefSeq Acc Id: XM_039097148   ⟹   XP_038953076
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21870,647,917 - 70,707,414 (+)NCBI
RefSeq Acc Id: XM_039097149   ⟹   XP_038953077
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21870,626,828 - 70,707,414 (+)NCBI
RefSeq Acc Id: XM_039097150   ⟹   XP_038953078
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21870,609,863 - 70,707,414 (+)NCBI
RefSeq Acc Id: XM_039097151   ⟹   XP_038953079
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21870,619,281 - 70,703,112 (+)NCBI
RefSeq Acc Id: XM_039097152   ⟹   XP_038953080
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21870,619,281 - 70,707,414 (+)NCBI
RefSeq Acc Id: XM_039097153   ⟹   XP_038953081
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21870,619,281 - 70,703,129 (+)NCBI
RefSeq Acc Id: XM_039097154   ⟹   XP_038953082
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21870,619,281 - 70,714,295 (+)NCBI
RefSeq Acc Id: XM_039097155   ⟹   XP_038953083
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21870,619,281 - 70,700,109 (+)NCBI
RefSeq Acc Id: XM_039097156   ⟹   XP_038953084
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21870,625,934 - 70,707,414 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_445789   ⟸   NM_053337
- Sequence:
RefSeq Acc Id: ENSRNOP00000023886   ⟸   ENSRNOT00000023886
RefSeq Acc Id: XP_038953072   ⟸   XM_039097144
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038953078   ⟸   XM_039097150
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038953074   ⟸   XM_039097146
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038953082   ⟸   XM_039097154
- Peptide Label: isoform X10
RefSeq Acc Id: XP_038953070   ⟸   XM_039097142
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038953071   ⟸   XM_039097143
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038953080   ⟸   XM_039097152
- Peptide Label: isoform X10
RefSeq Acc Id: XP_038953081   ⟸   XM_039097153
- Peptide Label: isoform X10
RefSeq Acc Id: XP_038953079   ⟸   XM_039097151
- Peptide Label: isoform X10
RefSeq Acc Id: XP_038953083   ⟸   XM_039097155
- Peptide Label: isoform X11
RefSeq Acc Id: XP_038953073   ⟸   XM_039097145
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038953075   ⟸   XM_039097147
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038953084   ⟸   XM_039097156
- Peptide Label: isoform X12
RefSeq Acc Id: XP_038953077   ⟸   XM_039097149
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038953076   ⟸   XM_039097148
- Peptide Label: isoform X7
RefSeq Acc Id: ENSRNOP00000092581   ⟸   ENSRNOT00000107723
RefSeq Acc Id: ENSRNOP00000092568   ⟸   ENSRNOT00000104069
RefSeq Acc Id: ENSRNOP00000097087   ⟸   ENSRNOT00000119543
RefSeq Acc Id: ENSRNOP00000086650   ⟸   ENSRNOT00000110007
RefSeq Acc Id: ENSRNOP00000097965   ⟸   ENSRNOT00000101274
Protein Domains
PINIT   SAP   SP-RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AZ28-F1-model_v2 AlphaFold Q6AZ28 1-572 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71056 AgrOrtholog
BioCyc Gene G2FUF-6946 BioCyc
Ensembl Genes ENSRNOG00000017493 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000023886 ENTREZGENE
  ENSRNOP00000023886.5 UniProtKB/TrEMBL
  ENSRNOP00000086650 ENTREZGENE
  ENSRNOP00000086650.1 UniProtKB/TrEMBL
  ENSRNOP00000092568 ENTREZGENE
  ENSRNOP00000092568.1 UniProtKB/TrEMBL
  ENSRNOP00000092581 ENTREZGENE
  ENSRNOP00000092581.1 UniProtKB/TrEMBL
  ENSRNOP00000097087 ENTREZGENE
  ENSRNOP00000097087.1 UniProtKB/TrEMBL
  ENSRNOP00000097965.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023886 ENTREZGENE
  ENSRNOT00000023886.6 UniProtKB/TrEMBL
  ENSRNOT00000101274.1 UniProtKB/TrEMBL
  ENSRNOT00000104069 ENTREZGENE
  ENSRNOT00000104069.1 UniProtKB/TrEMBL
  ENSRNOT00000107723 ENTREZGENE
  ENSRNOT00000107723.1 UniProtKB/TrEMBL
  ENSRNOT00000110007 ENTREZGENE
  ENSRNOT00000110007.1 UniProtKB/TrEMBL
  ENSRNOT00000119543 ENTREZGENE
  ENSRNOT00000119543.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.720.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.780 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7111628 IMAGE-MGC_LOAD
InterPro PIAS2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PINIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PINIT_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAP_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_MIZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83422 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93310 IMAGE-MGC_LOAD
NCBI Gene 83422 ENTREZGENE
PANTHER PTHR10782:SF12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PINIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-MIZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pias2 PhenoGen
PROSITE PINIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_SP_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF68906 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A470_RAT UniProtKB/TrEMBL
  A0A8I6AHS4_RAT UniProtKB/TrEMBL
  A0A8I6B6K3_RAT UniProtKB/TrEMBL
  A0A8I6GK87_RAT UniProtKB/TrEMBL
  A0A8I6GLW8_RAT UniProtKB/TrEMBL
  F1LRP3_RAT UniProtKB/TrEMBL
  PIAS2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q9Z177 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-02-06 Pias2  protein inhibitor of activated STAT, 2  Pias2  protein inhibitor of activated STAT 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Pias2  protein inhibitor of activated STAT 2  Miz1  Msx-interacting-zinc finger  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Miz1  Msx-interacting-zinc finger      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction binds to DNA-binding domain/zinc finger region of androgen receptor 70792
gene_protein 572 amino acids 70792