Enables nuclear receptor binding activity and protein domain specific binding activity. Involved in several processes, including androgen receptor signaling pathway; positive regulation of dendrite morphogenesis; and response to testosterone. Acts upstream of or within regulation of androgen receptor signaling pathway. Located in nucleus. Orthologous to human PIAS2 (protein inhibitor of activated STAT 2); PARTICIPATES IN androgen signaling pathway; Jak-Stat signaling pathway; hepatitis C pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; bisphenol A; finasteride.
androgen receptor-interacting protein 3; ARIP3; DAB2-interacting protein; DIP; E3 SUMO-protein ligase PIAS2; E3 SUMO-protein transferase PIAS2; Miz1; Msx-interacting-zinc finger; protein inhibitor of activated STAT 2; protein inhibitor of activated STAT x
lead nitrate affects the reaction [PIAS2 affects the expression of MT1 mRNA] and lead nitrate affects the reaction [PIAS2 affects the expression of MT2 mRNA]
[NOG protein co-treated with Mercuric Chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PIAS2 mRNA
[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of PIAS2 mRNA and [Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of PIAS2 mRNA
[NOG protein co-treated with Thimerosal co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PIAS2 mRNA
ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation.