Ntpcr (nucleoside-triphosphatase, cancer-related) - Rat Genome Database

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Gene: Ntpcr (nucleoside-triphosphatase, cancer-related) Rattus norvegicus
Analyze
Symbol: Ntpcr
Name: nucleoside-triphosphatase, cancer-related
RGD ID: 1306192
Description: Predicted to enable ribonucleoside triphosphate phosphatase activity. Predicted to be located in mitochondrion. Orthologous to human NTPCR (nucleoside-triphosphatase, cancer-related); PARTICIPATES IN thiamine metabolic pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cancer-related nucleoside-triphosphatase; LOC361443; nucleoside-triphosphatase C1orf57; nucleoside-triphosphatase C1orf57 homolog; RGD1306192; similar to RIKEN cDNA 2310079N02
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81970,598,816 - 70,612,580 (+)NCBIGRCr8
mRatBN7.21953,701,496 - 53,715,260 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1953,695,976 - 53,715,202 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1960,492,517 - 60,506,338 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01961,350,872 - 61,364,561 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01963,426,814 - 63,440,504 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01958,565,576 - 58,579,276 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1958,565,576 - 58,579,265 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01969,262,818 - 69,276,518 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41955,939,045 - 55,952,745 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11955,935,403 - 55,957,241 (+)NCBI
Celera1953,062,575 - 53,076,275 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19946888   PMID:22681889   PMID:23376485   PMID:28755400   PMID:34800366  


Genomics

Comparative Map Data
Ntpcr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81970,598,816 - 70,612,580 (+)NCBIGRCr8
mRatBN7.21953,701,496 - 53,715,260 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1953,695,976 - 53,715,202 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1960,492,517 - 60,506,338 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01961,350,872 - 61,364,561 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01963,426,814 - 63,440,504 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01958,565,576 - 58,579,276 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1958,565,576 - 58,579,265 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01969,262,818 - 69,276,518 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41955,939,045 - 55,952,745 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11955,935,403 - 55,957,241 (+)NCBI
Celera1953,062,575 - 53,076,275 (+)NCBICelera
Cytogenetic Map19q12NCBI
NTPCR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381232,950,611 - 232,983,882 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1232,950,605 - 232,983,882 (+)EnsemblGRCh38hg38GRCh38
GRCh371233,086,357 - 233,119,628 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361231,152,993 - 231,180,842 (+)NCBINCBI36Build 36hg18NCBI36
Celera1206,356,751 - 206,384,600 (+)NCBICelera
Cytogenetic Map1q42.2NCBI
HuRef1203,576,326 - 203,604,129 (+)NCBIHuRef
CHM1_11234,359,916 - 234,387,769 (+)NCBICHM1_1
T2T-CHM13v2.01232,336,950 - 232,370,221 (+)NCBIT2T-CHM13v2.0
Ntpcr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398126,456,724 - 126,474,974 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8126,456,702 - 126,474,974 (+)EnsemblGRCm39 Ensembl
GRCm388125,729,975 - 125,748,235 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8125,729,963 - 125,748,235 (+)EnsemblGRCm38mm10GRCm38
MGSCv378128,258,103 - 128,272,135 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368128,620,319 - 128,634,300 (+)NCBIMGSCv36mm8
Celera8130,047,167 - 130,061,146 (+)NCBICelera
Cytogenetic Map8E2NCBI
cM Map873.65NCBI
Ntpcr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554926,253,087 - 6,279,016 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554926,253,087 - 6,279,016 (-)NCBIChiLan1.0ChiLan1.0
NTPCR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2116,228,786 - 16,256,987 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1116,435,012 - 16,463,205 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01208,488,080 - 208,521,291 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11213,514,986 - 213,543,680 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1213,514,986 - 213,543,680 (+)Ensemblpanpan1.1panPan2
NTPCR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.146,704,571 - 6,733,820 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha46,693,240 - 6,722,006 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.046,726,875 - 6,755,692 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl46,725,334 - 6,756,323 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.146,736,907 - 6,765,707 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.046,857,165 - 6,885,962 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.047,081,335 - 7,110,107 (-)NCBIUU_Cfam_GSD_1.0
Ntpcr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934442,392,764 - 42,407,048 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648418,557,958 - 18,571,254 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648418,557,999 - 18,571,236 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NTPCR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1457,802,565 - 57,833,151 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11457,802,564 - 57,833,155 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NTPCR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12570,162,533 - 70,190,936 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2570,162,571 - 70,190,517 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605572,116,323 - 72,149,590 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ntpcr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477517,006,662 - 17,033,740 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477516,996,658 - 17,033,745 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ntpcr
104 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:270
Count of miRNA genes:177
Interacting mature miRNAs:203
Transcripts:ENSRNOT00000026965
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat

Markers in Region
AU028904  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81970,604,559 - 70,604,648 (+)Marker Load Pipeline
mRatBN7.21953,707,239 - 53,707,328 (+)MAPPERmRatBN7.2
Rnor_6.01958,571,320 - 58,571,408NCBIRnor6.0
Rnor_5.01969,268,562 - 69,268,650UniSTSRnor5.0
RGSC_v3.41955,944,789 - 55,944,877UniSTSRGSC3.4
Celera1953,068,319 - 53,068,407UniSTS
Cytogenetic Map19q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000026965   ⟹   ENSRNOP00000026965
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1953,695,976 - 53,715,202 (+)Ensembl
Rnor_6.0 Ensembl1958,565,576 - 58,579,265 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099966   ⟹   ENSRNOP00000086708
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1953,702,984 - 53,712,853 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111023   ⟹   ENSRNOP00000085117
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1953,702,000 - 53,715,202 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111221   ⟹   ENSRNOP00000090123
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1953,702,971 - 53,715,202 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114770   ⟹   ENSRNOP00000083457
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1953,701,469 - 53,713,215 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116565   ⟹   ENSRNOP00000096985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1953,701,469 - 53,705,027 (+)Ensembl
RefSeq Acc Id: NM_001134573   ⟹   NP_001128045
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81970,598,816 - 70,612,516 (+)NCBI
mRatBN7.21953,701,496 - 53,715,196 (+)NCBI
Rnor_6.01958,565,576 - 58,579,276 (+)NCBI
Rnor_5.01969,262,818 - 69,276,518 (+)NCBI
RGSC_v3.41955,939,045 - 55,952,745 (+)RGD
Celera1953,062,575 - 53,076,275 (+)RGD
Sequence:
RefSeq Acc Id: XM_039097902   ⟹   XP_038953830
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81970,600,638 - 70,612,580 (+)NCBI
mRatBN7.21953,701,515 - 53,715,260 (+)NCBI
RefSeq Acc Id: NP_001128045   ⟸   NM_001134573
- UniProtKB: A6KJ39 (UniProtKB/TrEMBL),   A0A8I6A3A7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026965   ⟸   ENSRNOT00000026965
RefSeq Acc Id: XP_038953830   ⟸   XM_039097902
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000085117   ⟸   ENSRNOT00000111023
Ensembl Acc Id: ENSRNOP00000096985   ⟸   ENSRNOT00000116565
Ensembl Acc Id: ENSRNOP00000090123   ⟸   ENSRNOT00000111221
Ensembl Acc Id: ENSRNOP00000083457   ⟸   ENSRNOT00000114770
Ensembl Acc Id: ENSRNOP00000086708   ⟸   ENSRNOT00000099966
Protein Domains
AAA+ ATPase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A478-F1-model_v2 AlphaFold D4A478 1-192 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701250
Promoter ID:EPDNEW_R11773
Type:initiation region
Name:Ntpcr_1
Description:nucleoside-triphosphatase, cancer-related
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01958,565,612 - 58,565,672EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306192 AgrOrtholog
BioCyc Gene G2FUF-5203 BioCyc
Ensembl Genes ENSRNOG00000019922 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026965.8 UniProtKB/TrEMBL
  ENSRNOT00000099966.1 UniProtKB/TrEMBL
  ENSRNOT00000111023.1 UniProtKB/TrEMBL
  ENSRNOT00000111221.1 UniProtKB/TrEMBL
  ENSRNOT00000114770.1 UniProtKB/TrEMBL
  ENSRNOT00000116565.1 UniProtKB/TrEMBL
  ENSRNOT00000141375 ENTREZGENE
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro ATPase_AAA+_core UniProtKB/TrEMBL
  DUF265 UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report rno:361443 UniProtKB/TrEMBL
NCBI Gene 361443 ENTREZGENE
PANTHER CANCER-RELATED NUCLEOSIDE-TRIPHOSPHATASE UniProtKB/TrEMBL
  PTHR43146 UniProtKB/TrEMBL
Pfam DUF265 UniProtKB/TrEMBL
PhenoGen Ntpcr PhenoGen
RatGTEx ENSRNOG00000019922 RatGTEx
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8I6A3A7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AMZ9_RAT UniProtKB/TrEMBL
  A0A8I6G928_RAT UniProtKB/TrEMBL
  A0A8I6GF87_RAT UniProtKB/TrEMBL
  A0A8I6GIM3_RAT UniProtKB/TrEMBL
  A6KJ39 ENTREZGENE, UniProtKB/TrEMBL
  D4A478_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-05-26 Ntpcr  nucleoside-triphosphatase, cancer-related  RGD1306192  similar to RIKEN cDNA 2310079N02  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1306192  similar to RIKEN cDNA 2310079N02   RGD1306192_predicted  similar to RIKEN cDNA 2310079N02 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1306192_predicted  similar to RIKEN cDNA 2310079N02 (predicted)  LOC361443_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC361443_predicted  similar to RIKEN cDNA 2310079N02 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL