Cfd (complement factor D) - Rat Genome Database

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Gene: Cfd (complement factor D) Rattus norvegicus
Symbol: Cfd
Name: complement factor D
RGD ID: 2498
Description: Enables endopeptidase activity. Involved in Notch signaling pathway. Located in extracellular space. Used to study arthus reaction. Biomarker of obesity. Orthologous to human CFD (complement factor D); PARTICIPATES IN coagulation cascade pathway; complement system pathway; Staphylococcus aureus infection pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Previously known as: adipsin; Adn; C3 convertase activator; complement factor D (adipsin); D component of complement (adipsin); Df; endogenous vascular elastase; EVE; properdin factor D
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.279,813,148 - 9,814,871 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,813,150 - 9,815,053 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,695,134 - 12,696,857 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0714,570,451 - 14,572,174 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0712,431,649 - 12,433,373 (-)NCBIRnor_WKY
Rnor_6.0712,634,216 - 12,635,939 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,634,216 - 12,635,943 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,803,938 - 12,805,661 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,325,538 - 11,327,261 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,325,546 - 11,327,251 (-)NCBI
Celera77,987,896 - 7,989,620 (-)NCBICelera
RH 3.4 Map741.1RGD
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-ephedrine  (ISO)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
D-glucose  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dicrotophos  (ISO)
dimethylarsinic acid  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
fenthion  (ISO)
flutamide  (EXP)
gallocatechin  (EXP)
glucose  (EXP)
graphite  (ISO)
heptachlor  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
lamivudine  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lidocaine  (EXP)
lithium chloride  (ISO)
lutein  (ISO)
magnesium atom  (ISO)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
metformin  (ISO)
mifepristone  (ISO)
monosodium L-glutamate  (ISO)
Muraglitazar  (EXP)
ozone  (ISO)
paclitaxel  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (ISO)
pioglitazone  (ISO)
potassium bromate  (EXP)
progesterone  (ISO)
raloxifene  (EXP)
resveratrol  (EXP,ISO)
rifaximin  (ISO)
saquinavir  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
tamoxifen  (EXP,ISO)
temozolomide  (ISO)
Tesaglitazar  (EXP)
thioacetamide  (EXP)
toxaphene  (EXP)
tributylstannane  (ISO)
trichloroethene  (EXP)
troglitazone  (EXP,ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
XL147  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular space  (IDA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Purification and partial characterization of rat factor D. Baker BC, etal., Biochem J. 1991 Nov 1;279 ( Pt 3):775-9.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Reduced adipsin mRNA and circulating adipsin protein are modulated by adrenal steroids in obese Zucker rats. Johnson PR, etal., Am J Physiol. 1990 Jul;259(1 Pt 2):R184-8.
4. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Adipsin expression and growth in rats as influenced by insulin and somatotropin. Miner JL, etal., Physiol Behav. 1993 Aug;54(2):207-12.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor. Searfoss GH, etal., J Biol Chem 2003 Nov 14;278(46):46107-16. Epub 2003 Aug 29.
14. The Arthus reaction in rodents: species-specific requirement of complement. Szalai AJ, etal., J Immunol. 2000 Jan 1;164(1):463-8.
15. Acylation-stimulating protein precursor proteins in adipose tissue in human obesity. Xia Z and Cianflone K, Metabolism. 2003 Oct;52(10):1360-6.
Additional References at PubMed
PMID:7592907   PMID:8083356   PMID:19056867   PMID:23012479   PMID:23376485   PMID:23533145   PMID:27564415   PMID:28057640  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.279,813,148 - 9,814,871 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,813,150 - 9,815,053 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,695,134 - 12,696,857 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0714,570,451 - 14,572,174 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0712,431,649 - 12,433,373 (-)NCBIRnor_WKY
Rnor_6.0712,634,216 - 12,635,939 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,634,216 - 12,635,943 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,803,938 - 12,805,661 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,325,538 - 11,327,261 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,325,546 - 11,327,251 (-)NCBI
Celera77,987,896 - 7,989,620 (-)NCBICelera
RH 3.4 Map741.1RGD
Cytogenetic Map7q11NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3819859,664 - 863,641 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl19859,453 - 867,884 (+)EnsemblGRCh38hg38GRCh38
GRCh3719859,664 - 863,641 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3619810,665 - 814,624 (+)NCBINCBI36Build 36hg18NCBI36
Build 3419810,664 - 814,608NCBI
Celera19784,591 - 789,264 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19628,736 - 632,629 (+)NCBIHuRef
CHM1_119859,248 - 863,166 (+)NCBICHM1_1
T2T-CHM13v2.019815,769 - 819,749 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391079,726,687 - 79,728,489 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,726,687 - 79,728,489 (+)EnsemblGRCm39 Ensembl
GRCm381079,890,853 - 79,892,655 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,890,853 - 79,892,655 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,353,598 - 79,355,401 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,294,041 - 79,295,783 (+)NCBIMGSCv36mm8
Celera1080,905,663 - 80,907,466 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0NW_0049554956,955,612 - 6,961,317 (-)NCBIChiLan1.0ChiLan1.0
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12057,785,297 - 57,787,773 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,657,154 - 57,787,713 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,587,313 - 57,589,790 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,527,568 - 58,530,058 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,527,625 - 58,529,997 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,582,382 - 57,584,835 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02058,062,090 - 58,064,488 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,265,041 - 58,267,518 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405118217,482,051 - 217,483,972 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588350,921 - 355,582 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936588350,925 - 352,732 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl277,509,795 - 77,511,974 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,509,792 - 77,511,988 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,485,653 - 77,487,849 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.16608,821 - 612,382 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl6608,800 - 613,498 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660818,304,252 - 8,308,149 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248287,711,537 - 7,717,337 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248287,714,926 - 7,717,139 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Cfd
8 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:83
Count of miRNA genes:75
Interacting mature miRNAs:77
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,814,007 - 9,814,256 (+)MAPPERmRatBN7.2
Rnor_6.0712,635,076 - 12,635,324NCBIRnor6.0
Rnor_5.0712,804,798 - 12,805,046UniSTSRnor5.0
RGSC_v3.4711,326,398 - 11,326,646UniSTSRGSC3.4
Celera77,988,756 - 7,989,005UniSTS
RH 3.4 Map741.1UniSTS
Cytogenetic Map7q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,813,196 - 9,813,566 (+)MAPPERmRatBN7.2
Rnor_6.0712,634,265 - 12,634,634NCBIRnor6.0
Rnor_5.0712,803,987 - 12,804,356UniSTSRnor5.0
RGSC_v3.4711,325,587 - 11,325,956UniSTSRGSC3.4
Celera77,987,945 - 7,988,314UniSTS
Cytogenetic Map7q11UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 5 39 23 19 23 8 11 7 13 8 8
Low 28 14 14 14 60 27 23 3
Below cutoff 2 4 4 4 12 1 5


Reference Sequences
RefSeq Acc Id: ENSRNOT00000015029   ⟹   ENSRNOP00000015029
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl79,813,150 - 9,815,053 (-)Ensembl
Rnor_6.0 Ensembl712,634,216 - 12,635,943 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093132   ⟹   ENSRNOP00000076084
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl712,634,216 - 12,634,641 (-)Ensembl
RefSeq Acc Id: NM_001077642   ⟹   NP_001071110
Rat AssemblyChrPosition (strand)Source
mRatBN7.279,813,148 - 9,814,871 (-)NCBI
Rnor_6.0712,634,216 - 12,635,939 (-)NCBI
Rnor_5.0712,803,938 - 12,805,661 (-)NCBI
RGSC_v3.4711,325,538 - 11,327,261 (-)RGD
Celera77,987,896 - 7,989,620 (-)RGD
Protein Sequences
Protein RefSeqs NP_001071110 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB31922 (Get FASTA)   NCBI Sequence Viewer  
  EDL89375 (Get FASTA)   NCBI Sequence Viewer  
  EDL89376 (Get FASTA)   NCBI Sequence Viewer  
  EDL89377 (Get FASTA)   NCBI Sequence Viewer  
  P32038 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001071110   ⟸   NM_001077642
- Peptide Label: precursor
- UniProtKB: P32038 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000076084   ⟸   ENSRNOT00000093132
RefSeq Acc Id: ENSRNOP00000015029   ⟸   ENSRNOT00000015029
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P32038-F1-model_v2 AlphaFold P32038 1-263 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13695043
Promoter ID:EPDNEW_R5568
Type:multiple initiation site
Description:complement factor D
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0712,635,951 - 12,636,011EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2498 AgrOrtholog
BioCyc Gene G2FUF-34896 BioCyc
Ensembl Genes ENSRNOG00000033564 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000015029 ENTREZGENE
  ENSRNOP00000015029.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015029 ENTREZGENE
  ENSRNOT00000015029.5 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Complement_factor_D UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54249 UniProtKB/Swiss-Prot
PANTHER PTHR24271:SF54 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cfd PhenoGen
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CFAD_RAT UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Cfd  complement factor D  Cfd  complement factor D (adipsin)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Cfd  complement factor D (adipsin)  Adn  adipsin  Symbol and Name updated 1299863 APPROVED
2002-11-06 Adn  adipsin  Df  D component of complement (adipsin)  Symbol and Name updated 625702 APPROVED
2002-06-10 Df  D component of complement (adipsin)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization secreted protein 1298875
gene_expression protein and mRNA expression is upregulated by functional gamma-secretase inhibitors in the intestinal contents and feces 1298875
gene_expression expression can be repressed by Hes-1 (the Notch-induced transcriptional regulator 1298875
gene_expression protein produced by cells present in the crypt region of the intestinal epithelium 1298875
gene_function serine protease adipocyte-specific protein mediated by the Notch/Hes-1 signaling pathway 1298875
gene_process potential marker for Notch/Hes-1 signaling disruption effects in the gastrointestinal tract 1298875
gene_regulation promoter binds Hes-1 at its cognate enhancer 1298875
gene_transcript interferes with bHLH binding to E-box elements in promoter region 1298875