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Gene: Pycr1 (pyrroline-5-carboxylate reductase 1) Rattus norvegicus
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Symbol: Pycr1
Name: pyrroline-5-carboxylate reductase 1
Description: Predicted to have identical protein binding activity and pyrroline-5-carboxylate reductase activity. Predicted to be involved in several processes, including L-proline biosynthetic process; negative regulation of hydrogen peroxide-induced cell death; and regulation of mitochondrial membrane potential. Predicted to localize to the mitochondrion. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIB and autosomal recessive cutis laxa type IIIB. Orthologous to human PYCR1 (pyrroline-5-carboxylate reductase 1); PARTICIPATES IN arginine and proline metabolic pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1-naphthyl isothiocyanate; 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC287877; pyrroline-5-carboxylate reductase 1, mitochondrial
Orthologs:
Homo sapiens (human) : PYCR1 (pyrroline-5-carboxylate reductase 1)  HGNC  Alliance
Mus musculus (house mouse) : Pycr1 (pyrroline-5-carboxylate reductase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pycr1 (pyrroline-5-carboxylate reductase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PYCR1 (pyrroline-5-carboxylate reductase 1)
Canis lupus familiaris (dog) : PYCR1 (pyrroline-5-carboxylate reductase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pycr1 (pyrroline-5-carboxylate reductase 1)
Sus scrofa (pig) : PYCR1 (pyrroline-5-carboxylate reductase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.010109,817,300 - 109,822,218 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.010109,411,300 - 109,414,609 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410110,030,931 - 110,035,883 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.110110,046,548 - 110,050,508 (-)NCBI
Celera10104,462,087 - 104,465,395 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Pycr1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1307863
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.