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Gene: Srd5a3 (steroid 5 alpha-reductase 3) Rattus norvegicus
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Symbol: Srd5a3
Name: steroid 5 alpha-reductase 3
Description: Predicted to have 3-oxo-5-alpha-steroid 4-dehydrogenase activity and oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor. Predicted to be involved in dolichol biosynthetic process; dolichol-linked oligosaccharide biosynthetic process; and polyprenol catabolic process. Predicted to localize to the endoplasmic reticulum. Human ortholog(s) of this gene implicated in Kahrizi syndrome and congenital disorder of glycosylation Iq. Orthologous to human SRD5A3 (steroid 5 alpha-reductase 3); PARTICIPATES IN steroid hormone biosynthetic pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 3-oxo-5-alpha-steroid 4-dehydrogenase 3; LOC305291; polyprenol reductase; probable polyprenol reductase; RGD1308828; S5AR 3; similar to SRD5A2L; SR type 3; steroid 5-alpha-reductase 3
Orthologs:
Homo sapiens (human) : SRD5A3 (steroid 5 alpha-reductase 3)  HGNC  Alliance
Mus musculus (house mouse) : Srd5a3 (steroid 5 alpha-reductase 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Srd5a3 (steroid 5 alpha-reductase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SRD5A3 (steroid 5 alpha-reductase 3)
Canis lupus familiaris (dog) : SRD5A3 (steroid 5 alpha-reductase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Srd5a3 (steroid 5 alpha-reductase 3)
Sus scrofa (pig) : LOC100525350 (polyprenol reductase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01434,554,769 - 34,570,423 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1434,556,220 - 34,570,356 (-)Ensembl
Rnor_5.01434,387,218 - 34,402,885 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41434,318,370 - 34,333,413 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11434,318,370 - 34,333,413 (-)NCBI
Celera1431,347,467 - 31,361,593 (-)NCBICelera
Cytogenetic Map14p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Srd5a3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1308828
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.