Slc25a23 (solute carrier family 25 member 23) - Rat Genome Database

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Gene: Slc25a23 (solute carrier family 25 member 23) Rattus norvegicus
Analyze
Symbol: Slc25a23
Name: solute carrier family 25 member 23
RGD ID: 1588586
Description: Predicted to enable ATP transmembrane transporter activity. Predicted to be involved in several processes, including calcium import into the mitochondrion; positive regulation of mitochondrial calcium ion concentration; and purine ribonucleotide transport. Predicted to act upstream of or within several processes, including adenine nucleotide transport; cellular response to calcium ion; and regulation of oxidative phosphorylation. Predicted to be located in mitochondrion. Orthologous to human SLC25A23 (solute carrier family 25 member 23); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: calcium-binding mitochondrial carrier protein SCaMC-3; LOC301113; phosphate carrier), member 23; phosphate carrier, member 23; similar to solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 23; solute carrier family 25 (mitochondrial carrier; solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 23
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.291,882,636 - 1,898,340 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,882,621 - 1,898,561 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx92,318,184 - 2,332,116 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.097,667,541 - 7,681,473 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.096,623,402 - 6,637,334 (-)NCBIRnor_WKY
Rnor_6.099,987,988 - 10,003,599 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl99,988,055 - 10,001,962 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.098,988,689 - 9,004,249 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera96,619,249 - 6,633,160 (+)NCBICelera
Cytogenetic Map9q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dichloroethane  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
antirheumatic drug  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
carbon nanotube  (ISO)
choline  (ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP)
cocaine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
dicrotophos  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fenthion  (ISO)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
gallic acid  (ISO)
gentamycin  (EXP)
heroin  (ISO)
hydrogen peroxide  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctanoic acid  (EXP)
phenformin  (EXP)
pirinixic acid  (EXP,ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium dichromate  (EXP)
succimer  (ISO)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
toluene  (EXP)
trichloroethene  (EXP)
troglitazone  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18614015   PMID:23344948   PMID:24430870   PMID:26975899  


Genomics

Comparative Map Data
Slc25a23
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.291,882,636 - 1,898,340 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,882,621 - 1,898,561 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx92,318,184 - 2,332,116 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.097,667,541 - 7,681,473 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.096,623,402 - 6,637,334 (-)NCBIRnor_WKY
Rnor_6.099,987,988 - 10,003,599 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl99,988,055 - 10,001,962 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.098,988,689 - 9,004,249 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera96,619,249 - 6,633,160 (+)NCBICelera
Cytogenetic Map9q12NCBI
SLC25A23
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38196,436,081 - 6,459,792 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl196,436,079 - 6,465,203 (-)EnsemblGRCh38hg38GRCh38
GRCh37196,440,075 - 6,459,803 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36196,391,075 - 6,410,781 (-)NCBINCBI36Build 36hg18NCBI36
Build 34196,391,074 - 6,410,781NCBI
Celera196,379,913 - 6,399,607 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef196,200,943 - 6,222,762 (-)NCBIHuRef
CHM1_1196,439,650 - 6,459,340 (-)NCBICHM1_1
T2T-CHM13v2.0196,429,579 - 6,449,293 (-)NCBIT2T-CHM13v2.0
Slc25a23
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391757,350,711 - 57,366,909 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1757,350,711 - 57,366,863 (-)EnsemblGRCm39 Ensembl
GRCm381757,043,711 - 57,059,909 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1757,043,711 - 57,059,863 (-)EnsemblGRCm38mm10GRCm38
MGSCv371757,183,134 - 57,199,286 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361756,728,621 - 56,745,010 (-)NCBIMGSCv36mm8
Celera1761,391,640 - 61,407,783 (-)NCBICelera
Cytogenetic Map17DNCBI
Slc25a23
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554953,155,224 - 3,170,369 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554953,155,024 - 3,171,279 (+)NCBIChiLan1.0ChiLan1.0
SLC25A23
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1196,388,937 - 6,410,481 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl196,388,937 - 6,410,480 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0195,474,538 - 5,487,364 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SLC25A23
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12053,722,841 - 53,736,205 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2053,722,320 - 53,733,331 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2053,469,862 - 53,483,134 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02054,376,787 - 54,390,281 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2054,376,781 - 54,390,615 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12053,443,639 - 53,456,913 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02053,892,079 - 53,905,333 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02054,121,061 - 54,134,550 (+)NCBIUU_Cfam_GSD_1.0
Slc25a23
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118214,028,801 - 214,045,845 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365883,792,778 - 3,808,593 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365883,792,760 - 3,804,788 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC25A23
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl272,625,583 - 72,641,791 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1272,625,544 - 72,643,572 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2272,958,959 - 72,965,057 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC25A23
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.166,042,186 - 6,063,969 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl66,044,516 - 6,063,842 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660811,934,087 - 1,959,948 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc25a23
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248283,559,813 - 3,572,395 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248283,558,034 - 3,572,426 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc25a23
36 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:263
Count of miRNA genes:140
Interacting mature miRNAs:186
Transcripts:ENSRNOT00000073000
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9114209783Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat

Markers in Region
RH130918  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.291,888,655 - 1,889,908 (-)MAPPERmRatBN7.2
Rnor_6.099,996,328 - 9,997,580NCBIRnor6.0
Rnor_5.098,996,978 - 8,998,230UniSTSRnor5.0
Celera96,627,522 - 6,628,774UniSTS
Cytogenetic Map9q11UniSTS
UniSTS:547044  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.291,883,453 - 1,884,234 (-)MAPPERmRatBN7.2
Rnor_6.0910,002,001 - 10,002,781NCBIRnor6.0
Rnor_5.099,002,651 - 9,003,431UniSTSRnor5.0
Celera96,633,199 - 6,633,979UniSTS
Cytogenetic Map9q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 33 39 31 31 8 11 74 31 25 7 8
Low 1 10 18 10 19 10 4 16 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000073000   ⟹   ENSRNOP00000064402
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl91,882,621 - 1,898,561 (-)Ensembl
Rnor_6.0 Ensembl99,988,057 - 10,001,962 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000086575   ⟹   ENSRNOP00000069437
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl91,882,621 - 1,898,561 (-)Ensembl
Rnor_6.0 Ensembl99,988,055 - 9,999,954 (+)Ensembl
RefSeq Acc Id: NM_001106873   ⟹   NP_001100343
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.291,884,273 - 1,898,179 (-)NCBI
Rnor_6.099,988,057 - 10,001,962 (+)NCBI
Rnor_5.098,988,689 - 9,004,249 (+)NCBI
Celera96,619,249 - 6,633,160 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596319   ⟹   XP_017451808
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.291,882,636 - 1,898,336 (-)NCBI
Rnor_6.099,987,988 - 10,003,599 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039083133   ⟹   XP_038939061
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.291,882,636 - 1,898,336 (-)NCBI
RefSeq Acc Id: XM_039083134   ⟹   XP_038939062
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.291,882,636 - 1,898,340 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001100343 (Get FASTA)   NCBI Sequence Viewer  
  XP_017451808 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939061 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939062 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL83585 (Get FASTA)   NCBI Sequence Viewer  
  EDL83586 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001100343   ⟸   NM_001106873
- UniProtKB: M0R4V4 (UniProtKB/TrEMBL),   A0A0G2JVD2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451808   ⟸   XM_017596319
- Peptide Label: isoform X1
- UniProtKB: M0R4V4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000064402   ⟸   ENSRNOT00000073000
RefSeq Acc Id: ENSRNOP00000069437   ⟸   ENSRNOT00000086575
RefSeq Acc Id: XP_038939062   ⟸   XM_039083134
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038939061   ⟸   XM_039083133
- Peptide Label: isoform X2
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R4V4-F1-model_v2 AlphaFold M0R4V4 1-467 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1588586 AgrOrtholog
BioCyc Gene G2FUF-28493 BioCyc
Ensembl Genes ENSRNOG00000047781 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000064402 ENTREZGENE
  ENSRNOP00000064402.2 UniProtKB/TrEMBL
  ENSRNOP00000069437 ENTREZGENE
  ENSRNOP00000069437.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000073000 ENTREZGENE
  ENSRNOT00000073000.3 UniProtKB/TrEMBL
  ENSRNOT00000086575 ENTREZGENE
  ENSRNOT00000086575.2 UniProtKB/TrEMBL
Gene3D-CATH 1.50.40.10 UniProtKB/TrEMBL
InterPro EF-hand-like_dom UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  Mit_carrier UniProtKB/TrEMBL
  Mitochondrial_sb/sol_carrier UniProtKB/TrEMBL
  Mt_carrier_dom UniProtKB/TrEMBL
KEGG Report rno:301113 UniProtKB/TrEMBL
NCBI Gene 301113 ENTREZGENE
Pfam EF_hand_5 UniProtKB/TrEMBL
  Mito_carr UniProtKB/TrEMBL
PhenoGen Slc25a23 PhenoGen
PRINTS MITOCARRIER UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
  SOLCAR UniProtKB/TrEMBL
SMART EFh UniProtKB/TrEMBL
Superfamily-SCOP Mitoch_carrier UniProtKB/TrEMBL
  SSF47473 UniProtKB/TrEMBL
UniProt A0A0G2JVD2 ENTREZGENE, UniProtKB/TrEMBL
  M0R4V4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Slc25a23  solute carrier family 25 member 23  Slc25a23  solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Slc25a23  solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23  LOC301113  similar to solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC301113  similar to solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23      Symbol and Name status set to provisional 70820 PROVISIONAL