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ONTOLOGY REPORT - ANNOTATIONS


Term:phenformin
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Accession:CHEBI:8064 term browser browse the term
Definition:A member of the class of biguanides that is biguanide in which one of the terminal nitrogen atoms is substituted by a 2-phenylethyl group. It was used as an anti-diabetic drug but was later withdrawn from the market due to potential risk of lactic acidosis.
Synonyms:exact_synonym: N-(2-phenylethyl)imidodicarbonimidic diamide
 related_synonym: DBI;   Formula=C10H15N5;   InChI=1S/C10H15N5/c11-9(12)15-10(13)14-7-6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H6,11,12,13,14,15);   InChIKey=ICFJFFQQTFMIBG-UHFFFAOYSA-N;   SMILES=NC(=N)NC(=N)NCCc1ccccc1;   fenformina;   phenformine;   phenforminum
 xref: CAS:114-86-3 "ChemIDplus";   CAS:114-86-3 "KEGG COMPOUND";   CAS:114-86-3 "NIST Chemistry WebBook";   DrugBank:DB00914;   Drug_Central:2126 "DrugCentral";   HMDB:HMDB0015050;   KEGG:C07673;   KEGG:D08351;   LINCS:LSM-2233
 xref_mesh: MESH:D010629
 xref: PMID:16567854 "Europe PMC";   PMID:18239244 "Europe PMC";   PMID:20188727 "Europe PMC";   PMID:22036620 "Europe PMC";   PMID:22361631 "Europe PMC";   PMID:23322141 "Europe PMC";   PMID:23475884 "Europe PMC";   PMID:23548904 "Europe PMC";   PMID:23612073 "Europe PMC";   Patent:US2961377;   Patent:US3057780;   Patent:WO2010114805;   Reaxys:1977317 "Reaxys";   Wikipedia:Phenformin


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phenformin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:6480464
G Lepr leptin receptor JBrowse link 5 120,503,475 120,682,281 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Plcg1 phospholipase C, gamma 1 JBrowse link 3 156,727,642 156,758,307 RGD:6480464
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 JBrowse link 2 54,857,688 54,893,404 RGD:6480464
G Serpinc1 serpin family C member 1 JBrowse link 13 78,806,107 78,820,375 RGD:6480464
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464
G Slc22a4 solute carrier family 22 member 4 JBrowse link 10 39,334,972 39,373,508 RGD:6480464
G Slc47a1 solute carrier family 47 member 1 JBrowse link 10 47,631,425 47,685,379 RGD:6480464
G Slc47a2 solute carrier family 47 member 2 JBrowse link 10 47,587,909 47,631,373 RGD:6480464
G Stat5b signal transducer and activator of transcription 5B JBrowse link 10 88,686,207 88,712,313 RGD:6480464
G Ugdh UDP-glucose 6-dehydrogenase JBrowse link 14 44,479,614 44,502,845 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        pharmaceutical 19097
          drug 19097
            antineoplastic agent 16555
              phenformin 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            heteroorganic entity 19003
                              organonitrogen compound 18076
                                guanidines 1453
                                  biguanide 550
                                    phenformin 15
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.