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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620259
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Eif4ebp1
Name: eukaryotic translation initiation factor 4E binding protein 1
Acc ID: CHEBI:6801
Term: metformin
Definition: A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Chemical ID: MESH:D008687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif4ebp1decreases phosphorylationISOEIF4EBP1 (Homo sapiens)150404268RGDMetformin decreases phosphorylation of EIF4EBP1 protein in epithelial cell of alveolus of lung  
Eif4ebp1decreases phosphorylationISOEIF4EBP1 (Homo sapiens)6480464CTDMetformin results in decreased phosphorylation of EIF4EBP1 proteinPMID:22108913
Eif4ebp1multiple interactionsISOEIF4EBP1 (Homo sapiens)6480464CTDMetformin results in decreased phosphorylation of and results in increased expression of EIF4EBP1 proteinPMID:23363784
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