Prkag2 (protein kinase AMP-activated non-catalytic subunit gamma 2) - Rat Genome Database

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Gene: Prkag2 (protein kinase AMP-activated non-catalytic subunit gamma 2) Rattus norvegicus
Analyze
Symbol: Prkag2
Name: protein kinase AMP-activated non-catalytic subunit gamma 2
RGD ID: 727782
Description: Enables AMP binding activity and protein kinase binding activity. Contributes to AMP-activated protein kinase activity. Involved in regulation of catalytic activity. Part of nucleotide-activated protein kinase complex. Human ortholog(s) of this gene implicated in Wolff-Parkinson-White syndrome; glycogen storage disease; hypertrophic cardiomyopathy 6; and lethal congenital glycogen storage disease of heart. Orthologous to human PRKAG2 (protein kinase AMP-activated non-catalytic subunit gamma 2); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; hypertrophic cardiomyopathy pathway; insulin signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; atrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5'-AMP-activated protein kinase subunit gamma-2; adenosine monophosphate-activated protein kinase gamma 2-subunit; AMP-activated protein kinase gamma2 subunit; AMPK gamma 2; protein kinase, AMP-activated, gamma 2 non-catalytic subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2410,010,574 - 10,252,152 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl410,010,890 - 10,252,142 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx415,010,338 - 15,251,331 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0410,824,590 - 11,065,587 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.049,177,184 - 9,418,166 (+)NCBIRnor_WKY
Rnor_6.046,559,153 - 6,799,888 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl46,559,545 - 6,799,632 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.046,577,007 - 6,816,813 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.445,620,992 - 5,667,438 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.145,620,991 - 5,667,437 (+)NCBI
Celera470,878 - 117,245 (-)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-tert-butylhydroquinone  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
andrographolide  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP,ISO)
Bardoxolone methyl  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
capsazepine  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
cobalt dichloride  (ISO)
cyclosporin A  (ISO)
DDT  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diazinon  (EXP)
diethyl maleate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
folic acid  (ISO)
folpet  (ISO)
fulvestrant  (ISO)
hydrogen cyanide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
levofloxacin  (EXP)
lycopene  (ISO)
manganese(II) chloride  (EXP)
metformin  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
O-methyleugenol  (ISO)
olanzapine  (ISO)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
ruthenium red  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sulforaphane  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (EXP)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Increased alpha2 subunit-associated AMPK activity and PRKAG2 cardiomyopathy. Ahmad F, etal., Circulation. 2005 Nov 15;112(20):3140-8. Epub 2005 Nov 7.
2. Fatal congenital heart glycogenosis caused by a recurrent activating R531Q mutation in the gamma 2-subunit of AMP-activated protein kinase (PRKAG2), not by phosphorylase kinase deficiency. Burwinkel B, etal., Am J Hum Genet. 2005 Jun;76(6):1034-49. Epub 2005 May 2.
3. Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding. Cheung PC, etal., Biochem J. 2000 Mar 15;346 Pt 3:659-69.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Novel PRKAG2 mutation responsible for the genetic syndrome of ventricular preexcitation and conduction system disease with childhood onset and absence of cardiac hypertrophy. Gollob MH, etal., Circulation. 2001 Dec 18;104(25):3030-3.
7. The AMP-activated protein kinase pathway--new players upstream and downstream. Hardie DG J Cell Sci. 2004 Nov 1;117(Pt 23):5479-87.
8. Management of cellular energy by the AMP-activated protein kinase system. Hardie DG, etal., FEBS Lett. 2003 Jul 3;546(1):113-20.
9. A new mutation in PRKAG2 gene causing hypertrophic cardiomyopathy with conduction system disease and muscular glycogenosis. Laforet P, etal., Neuromuscul Disord. 2006 Mar;16(3):178-82. Epub 2006 Feb 17.
10. Activation of AMPK alpha- and gamma-isoform complexes in the intact ischemic rat heart. Li J, etal., Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1927-34. Epub 2006 Apr 28.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Information Derived from GenBank Report RGD, Sept. 2003
19. Transgenic mouse model of ventricular preexcitation and atrioventricular reentrant tachycardia induced by an AMP-activated protein kinase loss-of-function mutation responsible for Wolff-Parkinson-White syndrome. Sidhu JS, etal., Circulation. 2005 Jan 4;111(1):21-9. Epub 2004 Dec 20.
Additional References at PubMed
PMID:11827995   PMID:12477932   PMID:15613684   PMID:17255938   PMID:22664934  


Genomics

Comparative Map Data
Prkag2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2410,010,574 - 10,252,152 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl410,010,890 - 10,252,142 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx415,010,338 - 15,251,331 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0410,824,590 - 11,065,587 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.049,177,184 - 9,418,166 (+)NCBIRnor_WKY
Rnor_6.046,559,153 - 6,799,888 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl46,559,545 - 6,799,632 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.046,577,007 - 6,816,813 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.445,620,992 - 5,667,438 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.145,620,991 - 5,667,437 (+)NCBI
Celera470,878 - 117,245 (-)NCBICelera
Cytogenetic Map4q11NCBI
PRKAG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387151,556,127 - 151,877,115 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl7151,556,124 - 151,877,125 (-)EnsemblGRCh38hg38GRCh38
GRCh377151,253,213 - 151,574,200 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367150,884,133 - 151,205,249 (-)NCBINCBI36Build 36hg18NCBI36
Build 347150,691,674 - 151,011,443NCBI
Celera7145,810,679 - 146,131,939 (-)NCBICelera
Cytogenetic Map7q36.1NCBI
HuRef7145,065,108 - 145,385,764 (-)NCBIHuRef
CHM1_17151,261,930 - 151,582,980 (-)NCBICHM1_1
T2T-CHM13v2.07152,728,659 - 153,049,942 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27150,582,427 - 150,901,526 (-)NCBI
Prkag2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39525,067,733 - 25,311,576 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl525,067,742 - 25,305,640 (-)EnsemblGRCm39 Ensembl
GRCm38524,862,735 - 25,106,282 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl524,862,744 - 25,100,642 (-)EnsemblGRCm38mm10GRCm38
MGSCv37524,368,553 - 24,606,460 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36524,372,822 - 24,610,495 (-)NCBIMGSCv36mm8
Celera521,815,075 - 22,050,879 (-)NCBICelera
Cytogenetic Map5A3NCBI
Prkag2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554915,852,082 - 6,019,318 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554915,852,534 - 6,048,820 (-)NCBIChiLan1.0ChiLan1.0
PRKAG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17155,292,675 - 155,610,673 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7155,293,748 - 155,610,078 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v07143,143,556 - 143,463,492 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PRKAG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11615,521,304 - 15,786,237 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1615,522,111 - 15,785,854 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1616,128,157 - 16,392,728 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01617,243,089 - 17,508,262 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1617,243,090 - 17,508,234 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11615,615,142 - 15,879,767 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01616,196,295 - 16,461,149 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01616,247,524 - 16,513,015 (-)NCBIUU_Cfam_GSD_1.0
Prkag2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244051185,735,796 - 5,995,632 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365276,909,044 - 7,167,600 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365276,907,723 - 7,168,222 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKAG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl185,475,077 - 5,744,657 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1185,475,077 - 5,744,761 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2186,107,245 - 6,143,586 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRKAG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121119,738,976 - 120,058,831 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21119,738,967 - 119,970,972 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607215,710,451 - 16,034,583 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkag2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248004,968,866 - 5,207,501 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248004,969,010 - 5,207,941 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prkag2
1115 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:86
Count of miRNA genes:71
Interacting mature miRNAs:73
Transcripts:ENSRNOT00000067183
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4127716890Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4127716890Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4127716890Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4129494328Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4130372989Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4521839229593287Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat

Markers in Region
D4Mgh23  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2410,248,900 - 10,249,102 (+)MAPPERmRatBN7.2
Rnor_6.046,796,634 - 6,796,835NCBIRnor6.0
Rnor_5.046,813,559 - 6,813,760UniSTSRnor5.0
RGSC_v3.445,664,196 - 5,664,398RGDRGSC3.4
RGSC_v3.445,664,197 - 5,664,398UniSTSRGSC3.4
RGSC_v3.145,664,152 - 5,664,479RGD
Celera473,918 - 74,119UniSTS
RH 2.0 Map412.5RGD
Cytogenetic Map4q11UniSTS
AI854673  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2410,251,048 - 10,251,169 (+)MAPPERmRatBN7.2
Rnor_6.046,798,782 - 6,798,902NCBIRnor6.0
Rnor_5.046,815,707 - 6,815,827UniSTSRnor5.0
RGSC_v3.445,666,345 - 5,666,465UniSTSRGSC3.4
Celera471,851 - 71,971UniSTS
Cytogenetic Map4q11UniSTS
RH140415  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2410,251,692 - 10,251,832 (+)MAPPERmRatBN7.2
Rnor_6.046,799,426 - 6,799,565NCBIRnor6.0
Rnor_5.046,816,351 - 6,816,490UniSTSRnor5.0
RGSC_v3.445,666,989 - 5,667,128UniSTSRGSC3.4
Celera471,188 - 71,327UniSTS
Cytogenetic Map4q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 36 10 7 9 7 74 29 37 11
Low 7 47 34 10 34 8 11 6 4 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001398879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_184051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY348865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY376854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC079017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC097267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000067183   ⟹   ENSRNOP00000062361
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl410,010,890 - 10,252,142 (+)Ensembl
Rnor_6.0 Ensembl46,559,545 - 6,799,632 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094824   ⟹   ENSRNOP00000076857
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl410,010,890 - 10,249,933 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106083   ⟹   ENSRNOP00000080463
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl410,114,474 - 10,252,142 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119089   ⟹   ENSRNOP00000095126
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl410,228,530 - 10,249,933 (+)Ensembl
RefSeq Acc Id: NM_184051   ⟹   NP_908940
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2410,205,688 - 10,252,142 (+)NCBI
Rnor_6.046,753,428 - 6,799,875 (+)NCBI
Rnor_5.046,577,007 - 6,816,813 (+)NCBI
RGSC_v3.445,620,992 - 5,667,438 (+)RGD
Celera470,878 - 117,245 (-)RGD
Sequence:
RefSeq Acc Id: XM_006235949   ⟹   XP_006236011
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2410,011,483 - 10,249,405 (+)NCBI
Rnor_6.046,559,153 - 6,797,138 (+)NCBI
Rnor_5.046,577,007 - 6,816,813 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006235951   ⟹   XP_006236013
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2410,011,483 - 10,252,152 (+)NCBI
Rnor_6.046,559,153 - 6,799,888 (+)NCBI
Rnor_5.046,577,007 - 6,816,813 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006235952   ⟹   XP_006236014
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2410,010,574 - 10,252,139 (+)NCBI
Rnor_6.046,559,463 - 6,799,872 (+)NCBI
Rnor_5.046,577,007 - 6,816,813 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006235955   ⟹   XP_006236017
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2410,114,270 - 10,252,152 (+)NCBI
Rnor_6.046,663,254 - 6,799,888 (+)NCBI
Rnor_5.046,577,007 - 6,816,813 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592729   ⟹   XP_017448218
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2410,011,483 - 10,249,048 (+)NCBI
Rnor_6.046,559,153 - 6,794,079 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592730   ⟹   XP_017448219
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2410,011,483 - 10,249,048 (+)NCBI
Rnor_6.046,559,153 - 6,794,079 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592731   ⟹   XP_017448220
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2410,049,093 - 10,249,048 (+)NCBI
Rnor_6.046,596,156 - 6,794,079 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592732   ⟹   XP_017448221
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2410,110,515 - 10,249,048 (+)NCBI
Rnor_6.046,661,945 - 6,794,079 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039107960   ⟹   XP_038963888
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2410,011,514 - 10,249,048 (+)NCBI
RefSeq Acc Id: XM_039107961   ⟹   XP_038963889
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2410,011,483 - 10,244,021 (+)NCBI
RefSeq Acc Id: XM_039107962   ⟹   XP_038963890
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2410,011,483 - 10,244,044 (+)NCBI
RefSeq Acc Id: XM_039107963   ⟹   XP_038963891
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2410,085,885 - 10,249,048 (+)NCBI
RefSeq Acc Id: XM_039107964   ⟹   XP_038963892
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2410,227,434 - 10,249,048 (+)NCBI
RefSeq Acc Id: XM_039107965   ⟹   XP_038963893
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2410,227,434 - 10,249,048 (+)NCBI
RefSeq Acc Id: XM_039107966   ⟹   XP_038963894
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2410,011,483 - 10,186,202 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_908940   ⟸   NM_184051
- UniProtKB: Q6V7V4 (UniProtKB/TrEMBL),   F1LM70 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236014   ⟸   XM_006235952
- Peptide Label: isoform X5
- UniProtKB: A0A140UHX4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236013   ⟸   XM_006235951
- Peptide Label: isoform X4
- UniProtKB: A0A140UHX4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236011   ⟸   XM_006235949
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006236017   ⟸   XM_006235955
- Peptide Label: isoform X12
- UniProtKB: A0A8I5ZQR3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448218   ⟸   XM_017592729
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017448219   ⟸   XM_017592730
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017448220   ⟸   XM_017592731
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_017448221   ⟸   XM_017592732
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: ENSRNOP00000062361   ⟸   ENSRNOT00000067183
RefSeq Acc Id: XP_038963890   ⟸   XM_039107962
- Peptide Label: isoform X10
RefSeq Acc Id: XP_038963889   ⟸   XM_039107961
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038963894   ⟸   XM_039107966
- Peptide Label: isoform X15
RefSeq Acc Id: XP_038963888   ⟸   XM_039107960
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038963891   ⟸   XM_039107963
- Peptide Label: isoform X11
RefSeq Acc Id: XP_038963892   ⟸   XM_039107964
- Peptide Label: isoform X13
RefSeq Acc Id: XP_038963893   ⟸   XM_039107965
- Peptide Label: isoform X14
RefSeq Acc Id: ENSRNOP00000095126   ⟸   ENSRNOT00000119089
RefSeq Acc Id: ENSRNOP00000080463   ⟸   ENSRNOT00000106083
RefSeq Acc Id: ENSRNOP00000076857   ⟸   ENSRNOT00000094824
Protein Domains
CBS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A140UHX4-F1-model_v2 AlphaFold A0A140UHX4 1-566 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692783
Promoter ID:EPDNEW_R3306
Type:multiple initiation site
Name:Prkag2_1
Description:protein kinase AMP-activated non-catalytic subunit gamma 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.046,559,597 - 6,559,657EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727782 AgrOrtholog
BioCyc Gene G2FUF-46077 BioCyc
Ensembl Genes ENSRNOG00000009085 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000062361 ENTREZGENE
  ENSRNOP00000062361.4 UniProtKB/TrEMBL
  ENSRNOP00000076857 ENTREZGENE
  ENSRNOP00000076857.1 UniProtKB/TrEMBL
  ENSRNOP00000080463 ENTREZGENE
  ENSRNOP00000080463.1 UniProtKB/TrEMBL
  ENSRNOP00000095126.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000067183 ENTREZGENE
  ENSRNOT00000067183.4 UniProtKB/TrEMBL
  ENSRNOT00000094824 ENTREZGENE
  ENSRNOT00000094824.1 UniProtKB/TrEMBL
  ENSRNOT00000106083 ENTREZGENE
  ENSRNOT00000106083.1 UniProtKB/TrEMBL
  ENSRNOT00000119089.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.580.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7445532 IMAGE-MGC_LOAD
InterPro AMPKG-2 UniProtKB/TrEMBL
  CBS_dom_sf UniProtKB/TrEMBL
  Cysta_beta_synth_core UniProtKB/TrEMBL
KEGG Report rno:373545 UniProtKB/TrEMBL
MGC_CLONE MGC:114237 IMAGE-MGC_LOAD
NCBI Gene 373545 ENTREZGENE
PANTHER PTHR13780:SF122 UniProtKB/TrEMBL
Pfam CBS UniProtKB/TrEMBL
PhenoGen Prkag2 PhenoGen
PROSITE CBS UniProtKB/TrEMBL
SMART CBS UniProtKB/TrEMBL
Superfamily-SCOP SSF54631 UniProtKB/TrEMBL
UniProt A0A140UHX4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y6F6_RAT UniProtKB/TrEMBL
  A0A8I5ZQR3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AJ26_RAT UniProtKB/TrEMBL
  F1LM70 ENTREZGENE
  Q4QRB9_RAT UniProtKB/TrEMBL
  Q6U7I6_RAT UniProtKB/TrEMBL
  Q6V7V4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1LM70 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Prkag2  protein kinase AMP-activated non-catalytic subunit gamma 2  Prkag2  protein kinase, AMP-activated, gamma 2 non-catalytic subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Prkag2  protein kinase, AMP-activated, gamma 2 non-catalytic subunit      Symbol and Name status set to approved 1299863 APPROVED