Bcar3 (BCAR3 adaptor protein, NSP family member) - Rat Genome Database

Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Bcar3 (BCAR3 adaptor protein, NSP family member) Rattus norvegicus
Analyze
Symbol: Bcar3
Name: BCAR3 adaptor protein, NSP family member
RGD ID: 1311688
Description: Predicted to enable kinase binding activity and phosphotyrosine residue binding activity. Predicted to be involved in several processes, including insulin receptor signaling pathway; positive regulation of nitrogen compound metabolic process; and positive regulation of signal transduction. Predicted to act upstream of or within lens morphogenesis in camera-type eye. Predicted to be located in focal adhesion and membrane. Orthologous to human BCAR3 (BCAR3 adaptor protein, NSP family member); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BCAR3 adapter protein, NSP family member; BCAR3, NSP family adaptor protein; BCAR3, NSP family adaptor protein 3; breast cancer anti-estrogen resistance 3; breast cancer anti-estrogen resistance protein 3; breast cancer anti-estrogen resistance protein 3 homolog; LOC310838; novel SH2-containing protein 2; p130Cas-binding protein AND-34; SH2 domain-containing protein 3B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22210,525,260 - 210,638,674 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2210,525,260 - 210,638,798 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2218,201,286 - 218,314,077 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02216,109,048 - 216,221,848 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02210,952,480 - 211,065,400 (+)NCBIRnor_WKY
Rnor_6.02226,563,050 - 226,679,449 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2226,563,050 - 226,679,438 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02245,929,016 - 246,041,127 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42219,075,206 - 219,188,344 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12219,044,367 - 219,151,409 (+)NCBI
Celera2202,953,635 - 203,067,717 (+)NCBICelera
Cytogenetic Map2q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxynon-2-enal  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
adefovir pivoxil  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
diclofenac  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
fenofibrate  (EXP)
ferroheme b  (ISO)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
heme b  (ISO)
isobutanol  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
metformin  (EXP)
methylmercury chloride  (ISO)
nickel dichloride  (EXP)
nitrofen  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
phenobarbital  (ISO)
piroxicam  (ISO)
progesterone  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
trovafloxacin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
focal adhesion  (ISO,ISS)
membrane  (ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Functional roles of BCAR3 in the signaling pathways of insulin leading to DNA synthesis, membrane ruffling and GLUT4 translocation. Oh MJ, etal., Biochem Biophys Res Commun. 2013 Nov 29;441(4):911-6. doi: 10.1016/j.bbrc.2013.10.161. Epub 2013 Nov 9.
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18722344   PMID:19086031   PMID:19365570   PMID:22801373  


Genomics

Comparative Map Data
Bcar3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22210,525,260 - 210,638,674 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2210,525,260 - 210,638,798 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2218,201,286 - 218,314,077 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02216,109,048 - 216,221,848 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02210,952,480 - 211,065,400 (+)NCBIRnor_WKY
Rnor_6.02226,563,050 - 226,679,449 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2226,563,050 - 226,679,438 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02245,929,016 - 246,041,127 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42219,075,206 - 219,188,344 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12219,044,367 - 219,151,409 (+)NCBI
Celera2202,953,635 - 203,067,717 (+)NCBICelera
Cytogenetic Map2q42NCBI
BCAR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38193,561,741 - 93,847,219 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl193,561,741 - 93,847,150 (-)EnsemblGRCh38hg38GRCh38
GRCh37194,027,298 - 94,312,775 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36193,799,936 - 93,919,973 (-)NCBINCBI36Build 36hg18NCBI36
Build 34193,739,371 - 93,859,223NCBI
Celera192,281,411 - 92,401,455 (-)NCBICelera
Cytogenetic Map1p22.1NCBI
HuRef192,148,818 - 92,431,346 (-)NCBIHuRef
CHM1_1194,142,284 - 94,427,714 (-)NCBICHM1_1
T2T-CHM13v2.0193,407,475 - 93,692,966 (-)NCBIT2T-CHM13v2.0
Bcar3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393122,213,406 - 122,323,840 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3122,087,785 - 122,323,840 (+)EnsemblGRCm39 Ensembl
GRCm383122,419,757 - 122,530,191 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3122,294,136 - 122,530,191 (+)EnsemblGRCm38mm10GRCm38
MGSCv373122,122,698 - 122,233,101 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363122,411,849 - 122,522,205 (+)NCBIMGSCv36mm8
Celera3128,819,836 - 128,930,961 (+)NCBICelera
Cytogenetic Map3G1NCBI
Bcar3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955423991,057 - 1,105,033 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955423991,046 - 1,105,033 (+)NCBIChiLan1.0ChiLan1.0
BCAR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1194,960,969 - 95,104,869 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl194,960,966 - 95,080,565 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0196,230,498 - 96,508,028 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
BCAR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1655,276,300 - 55,525,246 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl655,347,955 - 55,525,246 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha658,076,009 - 58,232,203 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0655,743,759 - 55,899,988 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl655,764,481 - 55,899,985 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1655,423,562 - 55,579,644 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0655,408,217 - 55,564,415 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0655,861,300 - 56,017,521 (+)NCBIUU_Cfam_GSD_1.0
Bcar3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058103,285,698 - 103,399,549 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365375,548,422 - 5,662,219 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCAR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4123,440,571 - 123,666,598 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14123,440,571 - 123,666,603 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24135,115,751 - 135,322,614 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BCAR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12039,399,818 - 39,679,686 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2039,566,157 - 39,680,660 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603378,358,639 - 78,653,780 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bcar3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247423,948,910 - 4,067,761 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247423,934,971 - 4,067,691 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bcar3
585 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:67
Count of miRNA genes:51
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000065111
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2185876309219753474Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2189599258218414891Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
2299161Iddm33Insulin dependent diabetes mellitus QTL 332.98blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2206312063220876787Rat
631203Gluco14Glucose level QTL 140.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)2206665645219003804Rat

Markers in Region
D2Got146  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22210,525,750 - 210,525,927 (+)MAPPERmRatBN7.2
Rnor_6.02226,563,541 - 226,563,715NCBIRnor6.0
Rnor_5.02245,929,507 - 245,929,681UniSTSRnor5.0
RGSC_v3.42219,075,696 - 219,075,871RGDRGSC3.4
RGSC_v3.42219,075,697 - 219,075,871UniSTSRGSC3.4
RGSC_v3.12219,038,759 - 219,038,933RGD
Celera2202,954,126 - 202,954,300UniSTS
RH 3.4 Map21536.9UniSTS
RH 3.4 Map21536.9RGD
RH 2.0 Map21102.9RGD
Cytogenetic Map2q42UniSTS
RH136843  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22210,638,326 - 210,638,507 (+)MAPPERmRatBN7.2
Rnor_6.02226,679,094 - 226,679,274NCBIRnor6.0
Rnor_5.02246,040,772 - 246,040,952UniSTSRnor5.0
RGSC_v3.42219,188,000 - 219,188,180UniSTSRGSC3.4
Celera2203,067,373 - 203,067,553UniSTS
Cytogenetic Map2q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 4 17 10 13 10 17 18 22 11
Low 39 40 31 6 31 8 11 57 17 19 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000065111   ⟹   ENSRNOP00000062880
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2210,525,260 - 210,638,671 (+)Ensembl
Rnor_6.0 Ensembl2226,563,050 - 226,679,438 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107706   ⟹   ENSRNOP00000076885
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2210,532,766 - 210,638,798 (+)Ensembl
RefSeq Acc Id: NM_001107722   ⟹   NP_001101192
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22210,525,260 - 210,638,671 (+)NCBI
Rnor_6.02226,563,050 - 226,679,438 (+)NCBI
Rnor_5.02245,929,016 - 246,041,127 (+)NCBI
RGSC_v3.42219,075,206 - 219,188,344 (+)RGD
Celera2202,953,635 - 203,067,717 (+)RGD
Sequence:
RefSeq Acc Id: XM_006233270   ⟹   XP_006233332
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22210,590,410 - 210,638,674 (+)NCBI
Rnor_6.02226,630,994 - 226,679,449 (+)NCBI
Rnor_5.02245,929,016 - 246,041,127 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039102442   ⟹   XP_038958370
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22210,525,296 - 210,638,674 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001101192 (Get FASTA)   NCBI Sequence Viewer  
  XP_006233332 (Get FASTA)   NCBI Sequence Viewer  
  XP_038958370 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D3ZAZ5 (Get FASTA)   NCBI Sequence Viewer  
  EDL82101 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001101192   ⟸   NM_001107722
- UniProtKB: D3ZAZ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233332   ⟸   XM_006233270
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000062880   ⟸   ENSRNOT00000065111
RefSeq Acc Id: XP_038958370   ⟸   XM_039102442
- Peptide Label: isoform X1
- UniProtKB: D3ZAZ5 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSRNOP00000076885   ⟸   ENSRNOT00000107706
Protein Domains
Ras-GEF   SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZAZ5-F1-model_v2 AlphaFold D3ZAZ5 1-825 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691724
Promoter ID:EPDNEW_R2249
Type:multiple initiation site
Name:Bcar3_1
Description:BCAR3, NSP family adaptor protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02226,563,279 - 226,563,339EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311688 AgrOrtholog
BioCyc Gene G2FUF-51356 BioCyc
Ensembl Genes ENSRNOG00000013737 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000062880 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000076885 ENTREZGENE
  ENSRNOP00000076885.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065111 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000107706 ENTREZGENE
  ENSRNOT00000107706.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.840.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BCAR3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ras_GEF_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASGEF_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASGEF_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_SHEP1/BCAR3/NSP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:310838 UniProtKB/Swiss-Prot
NCBI Gene 310838 ENTREZGENE
PANTHER PTHR14247:SF10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RasGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bcar3 PhenoGen
PROSITE RASGEF_CAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RasGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48366 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5Y0X0_RAT UniProtKB/TrEMBL
  BCAR3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-01 Bcar3  BCAR3 adaptor protein, NSP family member  Bcar3  BCAR3, NSP family adaptor protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-11-02 Bcar3  BCAR3, NSP family adaptor protein  Bcar3  BCAR3, NSP family adaptor protein 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-10-31 Bcar3  BCAR3, NSP family adaptor protein 3  Bcar3  breast cancer anti-estrogen resistance 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Bcar3  breast cancer anti-estrogen resistance 3   Bcar3_predicted  breast cancer anti-estrogen resistance 3 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Bcar3_predicted  breast cancer anti-estrogen resistance 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED