Bub1 (BUB1 mitotic checkpoint serine/threonine kinase) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Bub1 (BUB1 mitotic checkpoint serine/threonine kinase) Rattus norvegicus
Analyze
Symbol: Bub1
Name: BUB1 mitotic checkpoint serine/threonine kinase
RGD ID: 1311707
Description: Predicted to enable protein kinase activity. Involved in cell population proliferation. Predicted to be located in cytosol; kinetochore; and nucleoplasm. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human BUB1 (BUB1 mitotic checkpoint serine/threonine kinase); PARTICIPATES IN cell cycle pathway, mitotic; INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: budding uninhibited by benzimidazoles 1; budding uninhibited by benzimidazoles 1 homolog; budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae); budding uninhibited by benzimidazoles 1 homolog (yeast); LOC296137; mitotic checkpoint serine/threonine-protein kinase BUB1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23115,020,254 - 115,051,650 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3115,020,254 - 115,051,650 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3118,910,094 - 118,941,495 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03127,505,638 - 127,537,039 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03125,165,975 - 125,197,376 (-)NCBIRnor_WKY
Rnor_6.03120,373,604 - 120,404,910 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3120,373,604 - 120,404,910 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03126,929,123 - 126,960,429 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43115,323,510 - 115,354,906 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13115,230,064 - 115,260,294 (-)NCBI
Celera3113,854,710 - 113,886,108 (-)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-amphetamine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3-methylcholanthrene  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitroquinoline N-oxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amosite asbestos  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsenite(3-)  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cryptolepine  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
dioxygen  (EXP)
doxorubicin  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
eugenol  (ISO)
fluvastatin  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
geraniol  (ISO)
GW 4064  (ISO)
hydrogen peroxide  (ISO)
irinotecan  (EXP,ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lidocaine  (EXP)
lucanthone  (ISO)
malathion  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nocodazole  (ISO)
O-methyleugenol  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
PhIP  (ISO)
picoxystrobin  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
promethazine  (EXP)
propanal  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
silicon dioxide  (ISO)
silver(1+) nitrate  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (EXP)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mutations of mitotic checkpoint genes in human cancers. Cahill DP, etal., Nature. 1998 Mar 19;392(6673):300-3.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Mammalian BUB1 protein kinases: map positions and in vivo expression. Pangilinan F, etal., Genomics. 1997 Dec 15;46(3):379-88.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12355205   PMID:15020684   PMID:15226446   PMID:15723797   PMID:16760428   PMID:17227893   PMID:17938250   PMID:18084284   PMID:19465021   PMID:19487456   PMID:19946888   PMID:19965387  
PMID:22331848   PMID:24055156  


Genomics

Comparative Map Data
Bub1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23115,020,254 - 115,051,650 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3115,020,254 - 115,051,650 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3118,910,094 - 118,941,495 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03127,505,638 - 127,537,039 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03125,165,975 - 125,197,376 (-)NCBIRnor_WKY
Rnor_6.03120,373,604 - 120,404,910 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3120,373,604 - 120,404,910 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03126,929,123 - 126,960,429 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43115,323,510 - 115,354,906 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13115,230,064 - 115,260,294 (-)NCBI
Celera3113,854,710 - 113,886,108 (-)NCBICelera
Cytogenetic Map3q36NCBI
BUB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382110,637,528 - 110,678,063 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2110,637,528 - 110,678,063 (-)EnsemblGRCh38hg38GRCh38
GRCh372111,395,105 - 111,435,640 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362111,111,881 - 111,152,135 (-)NCBINCBI36Build 36hg18NCBI36
Build 342111,111,642 - 111,151,895NCBI
Celera2105,046,046 - 105,086,323 (-)NCBICelera
Cytogenetic Map2q13NCBI
HuRef2104,274,404 - 104,314,815 (-)NCBIHuRef
CHM1_12111,399,569 - 111,439,978 (-)NCBICHM1_1
T2T-CHM13v2.02111,060,427 - 111,100,976 (-)NCBIT2T-CHM13v2.0
Bub1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392127,642,117 - 127,673,790 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2127,643,036 - 127,673,785 (-)EnsemblGRCm39 Ensembl
GRCm382127,800,197 - 127,831,859 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2127,801,122 - 127,831,865 (-)EnsemblGRCm38mm10GRCm38
MGSCv372127,625,936 - 127,657,595 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362127,492,562 - 127,523,236 (-)NCBIMGSCv36mm8
Celera2129,026,419 - 129,058,592 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map262.1NCBI
Bub1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554703,152,758 - 3,191,888 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554703,152,798 - 3,190,185 (+)NCBIChiLan1.0ChiLan1.0
BUB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A111,815,335 - 111,855,573 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A111,793,236 - 111,858,392 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A91,393,317 - 91,433,579 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
BUB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11735,208,989 - 35,252,296 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1735,208,991 - 35,252,975 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1734,978,541 - 35,021,465 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01735,980,361 - 36,023,634 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1735,980,365 - 36,023,641 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11735,107,041 - 35,149,998 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01735,176,457 - 35,219,422 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01735,386,576 - 35,429,599 (-)NCBIUU_Cfam_GSD_1.0
BUB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl345,585,226 - 45,624,543 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1345,585,188 - 45,623,240 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2347,568,892 - 47,584,217 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BUB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11413,647,342 - 13,698,061 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1413,647,462 - 13,697,932 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660805,994,677 - 6,036,649 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bub1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247491,584,186 - 1,639,770 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247491,584,289 - 1,639,334 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bub1
91 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:135
Count of miRNA genes:99
Interacting mature miRNAs:115
Transcripts:ENSRNOT00000051783
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3102200529115665732Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3112287552135181505Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 26 31 22 17 22 1 1 39 21 37 1 1
Low 17 26 19 2 19 7 9 35 13 4 10 7
Below cutoff 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000051783   ⟹   ENSRNOP00000042114
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3115,020,254 - 115,051,650 (-)Ensembl
Rnor_6.0 Ensembl3120,373,604 - 120,404,910 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111791   ⟹   ENSRNOP00000090348
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3115,020,254 - 115,051,456 (-)Ensembl
RefSeq Acc Id: NM_001106507   ⟹   NP_001099977
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23115,020,254 - 115,051,650 (-)NCBI
Rnor_6.03120,373,604 - 120,404,910 (-)NCBI
Rnor_5.03126,929,123 - 126,960,429 (+)NCBI
RGSC_v3.43115,323,510 - 115,354,906 (-)RGD
Celera3113,854,710 - 113,886,108 (-)RGD
Sequence:
RefSeq Acc Id: XM_039104570   ⟹   XP_038960498
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23115,021,231 - 115,051,480 (-)NCBI
RefSeq Acc Id: XM_039104571   ⟹   XP_038960499
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23115,021,231 - 115,048,933 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001099977 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960498 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960499 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL80129 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001099977   ⟸   NM_001106507
- UniProtKB: D4A5D3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000042114   ⟸   ENSRNOT00000051783
RefSeq Acc Id: XP_038960498   ⟸   XM_039104570
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038960499   ⟸   XM_039104571
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GIT9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000090348   ⟸   ENSRNOT00000111791
Protein Domains
BUB1 N-terminal   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A5D3-F1-model_v2 AlphaFold D4A5D3 1-1059 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692411
Promoter ID:EPDNEW_R2936
Type:initiation region
Name:Bub1_1
Description:BUB1 mitotic checkpoint serine/threonine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03120,404,702 - 120,404,762EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311707 AgrOrtholog
BioCyc Gene G2FUF-47957 BioCyc
Ensembl Genes ENSRNOG00000032778 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000042114 ENTREZGENE
  ENSRNOP00000042114.3 UniProtKB/TrEMBL
  ENSRNOP00000090348 ENTREZGENE
  ENSRNOP00000090348.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000051783 ENTREZGENE
  ENSRNOT00000051783.5 UniProtKB/TrEMBL
  ENSRNOT00000111791 ENTREZGENE
  ENSRNOT00000111791.1 UniProtKB/TrEMBL
InterPro Bub1 UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Mad3_BUB1_I UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_prot_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:296137 UniProtKB/TrEMBL
NCBI Gene 296137 ENTREZGENE
PANTHER Bub1 UniProtKB/TrEMBL
Pfam Mad3_BUB1_I UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Bub1 PhenoGen
PROSITE BUB1_N UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART Mad3_BUB1_I UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A8I6GIT9 ENTREZGENE, UniProtKB/TrEMBL
  D4A5D3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-23 Bub1  BUB1 mitotic checkpoint serine/threonine kinase  Bub1  budding uninhibited by benzimidazoles 1 homolog (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-01-14 Bub1  budding uninhibited by benzimidazoles 1 homolog (yeast)  Bub1  budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Bub1  budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)   Bub1_predicted  budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Bub1_predicted  budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (predicted)      Symbol and Name status set to approved 70820 APPROVED