BUB1 (BUB1 mitotic checkpoint serine/threonine kinase)

Gene: BUB1 (BUB1 mitotic checkpoint serine/threonine kinase) Sus scrofa

Analyze

Symbol:

BUB1

Name:

BUB1 mitotic checkpoint serine/threonine kinase

RGD ID:

14041896

Description:

ENCODES a protein that exhibits ATP binding (inferred); histone H2A kinase activity (inferred); protein kinase activity (inferred); INVOLVED IN chromosome segregation (ortholog); intrinsic apoptotic signaling pathway (ortholog); positive regulation of intrinsic apoptotic signaling pathway (ortholog); ASSOCIATED WITH colon carcinoma (ortholog); colorectal cancer (ortholog); Colorectal Neoplasms (ortholog); FOUND IN chromosome, centromeric region (ortholog); condensed chromosome, centromeric region (ortholog); INTERACTS WITH deoxynivalenol

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

budding uninhibited by benzimidazoles 1 homolog; mitotic checkpoint serine/threonine-protein kinase BUB1

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	45,585,226 - 45,624,543 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	45,585,188 - 45,623,240 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	47,568,892 - 47,584,217 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

colon carcinoma (ISO)

colorectal cancer (ISO)

Colorectal Neoplasms (ISO)

COVID-19 (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

Primary Autosomal Recessive Microcephaly 30 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

deoxynivalenol (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chromatin remodeling (IEA)

chromosome segregation (ISO)

intrinsic apoptotic signaling pathway (ISO)

meiotic sister chromatid cohesion, centromeric (IEA)

mitotic spindle assembly checkpoint signaling (IEA)

positive regulation of intrinsic apoptotic signaling pathway (ISO)

positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric (IEA)

regulation of chromosome segregation (IEA)

regulation of sister chromatid cohesion (IEA)

Cellular Component

chromosome, centromeric region (ISO)

condensed chromosome, centromeric region (ISO)

cytosol (IEA)

intracellular membrane-bounded organelle (IEA)

kinetochore (IEA)

nucleoplasm (IEA)

nucleus (IEA)

outer kinetochore (IEA)

Molecular Function

ATP binding (IEA)

histone H2A kinase activity (IEA)

protein binding (ISO)

protein kinase activity (IEA)

protein serine/threonine kinase activity (IEA)

References

Additional References at PubMed

PMID:14681463	PMID:17145712	PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

BUB1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	45,585,226 - 45,624,543 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	45,585,188 - 45,623,240 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	47,568,892 - 47,584,217 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BUB1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	110,637,528 - 110,678,063 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	110,637,528 - 110,678,063 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	111,395,105 - 111,435,640 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	111,111,881 - 111,152,135 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	111,111,642 - 111,151,895	NCBI
Celera	2	105,046,046 - 105,086,323 (-)	NCBI		Celera
Cytogenetic Map	2	q13	NCBI
HuRef	2	104,274,404 - 104,314,815 (-)	NCBI		HuRef
CHM1_1	2	111,399,569 - 111,439,978 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	111,060,427 - 111,100,976 (-)	NCBI		T2T-CHM13v2.0

Bub1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	127,642,117 - 127,673,790 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	127,643,036 - 127,673,785 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	127,800,197 - 127,831,859 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	127,801,122 - 127,831,865 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	127,625,936 - 127,657,595 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	127,492,562 - 127,523,236 (-)	NCBI		MGSCv36	mm8
Celera	2	129,026,419 - 129,058,592 (-)	NCBI		Celera
Cytogenetic Map	2	F1	NCBI
cM Map	2	62.1	NCBI

Bub1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	135,473,525 - 135,504,921 (-)	NCBI		GRCr8
mRatBN7.2	3	115,020,254 - 115,051,650 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	115,020,254 - 115,051,650 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	118,910,094 - 118,941,495 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	127,505,638 - 127,537,039 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	125,165,975 - 125,197,376 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	120,373,604 - 120,404,910 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	120,373,604 - 120,404,910 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	126,929,123 - 126,960,429 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	115,323,510 - 115,354,906 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	115,230,064 - 115,260,294 (-)	NCBI
Celera	3	113,854,710 - 113,886,108 (-)	NCBI		Celera
Cytogenetic Map	3	q36	NCBI

Bub1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955470	3,152,758 - 3,191,888 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955470	3,152,798 - 3,190,185 (+)	NCBI	ChiLan1.0	ChiLan1.0

BUB1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	17,445,607 - 17,533,774 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	17,448,057 - 17,488,719 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	91,393,317 - 91,433,579 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	111,815,335 - 111,855,573 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	111,793,236 - 111,858,392 (+)	Ensembl	panpan1.1		panPan2

BUB1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	35,208,989 - 35,252,296 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	35,208,991 - 35,252,975 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	34,978,541 - 35,021,465 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	35,980,361 - 36,023,634 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	35,980,365 - 36,023,641 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	35,107,041 - 35,149,998 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	35,176,457 - 35,219,422 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	35,386,576 - 35,429,599 (-)	NCBI		UU_Cfam_GSD_1.0

BUB1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	13,647,342 - 13,698,061 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	13,647,462 - 13,697,932 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666080	5,994,677 - 6,036,649 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Bub1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624749	1,584,186 - 1,639,770 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624749	1,584,289 - 1,639,334 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in BUB1
943 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	hemolymphoid system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system
High
Medium
Low	9	4	2	5	2	2	2	3	3
Below cutoff	1		1			12

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021087046	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021087047	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK398372	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01006101	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSSCT00000025163 ⟹ ENSSSCP00000026685

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	3	45,585,226 - 45,624,543 (+)	Ensembl

RefSeq Acc Id:

ENSSSCT00000066450 ⟹ ENSSSCP00000065793

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	3	45,585,298 - 45,624,543 (+)	Ensembl

RefSeq Acc Id:

ENSSSCT00000071948 ⟹ ENSSSCP00000064616

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	3	45,585,226 - 45,624,543 (+)	Ensembl

RefSeq Acc Id:

ENSSSCT00000079878 ⟹ ENSSSCP00000072094

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	3	45,585,580 - 45,624,543 (+)	Ensembl

RefSeq Acc Id:

XM_021087046 ⟹ XP_020942705

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	3	45,585,197 - 45,623,240 (+)	NCBI

Sequence:

show sequence

GCTCGTTGCAGCGACTGCGGCTGCGCGGCAGATTCGAATCGGCGGCGGCTCCTCCACAGCAGCG
TAGTGGGGGGGTTCCGGCTGGCTCGCGTCCTCTCGCCATGGATAACCCGGAAAATGTCTTTCAA
ATGTTCGAAGCCCATATGCAGAGCTACAAGGGCGATGACCCACTTGGTGAATGGGAAAGTTATG
TGCGATGGGTAGAAGAGAATTTTCCTGAGAATAAAGAATACTTGACAACTTTATTAGAGCATCT
AATGAAGGAATTTTTAGATAAGAAGAGATACCACAGTGACCCAAGGTTCATCAATTATTGTTTA
AAATTTGCCGAGTACAACAGTGACCTTCATCAGTTTTTTGAGTTTCTCCACAACCATGGTGTCG
GGATCCGGTCAGCTCCTCTGTACATAGCCTGGGCTGGTCATCTGGAAGGCCAGGGAGAATGGCA
GCAAGCCAGCACTGTTTTTCACAGAGGAATTCAAAACCAGGCTGAACCTAGAGAGCTGCTGCAA
CAGCAGTACAGGTTGTTTCAGACACGCCTTGCGGAAACCCATTTACCGACTCAAGCGAGAATTT
TAGAACCTCTGCATGATGCTCAGATTATAAACCAAATGGTAACATCAAAATCAAATCCAGGAAA
TAACTCAGCCTGTGTTTCTAAGAAGCAGGGTTCAGAGCTTTCTGGAGTAATATCTTCAGCTTGT
GATAAAGAGCCGAATATGGAACAGAGGGTGATCATGATTTCTAAATCAGAATATTCTGCACACT
CATCTTTGGCGGCCAAAACTGACATTCAGCAGGTTGTTATGTATTGCAAGGAGAAGCTTATTTG
TGGAGAATCAGAATTTTCCTTTGAAGAACTGAGAGCCCAGAAATACAATCAGCGGAGGAAACAT
GAGCAATGGGTCCATGAAGACAGGCATTATATGAAAAGGAAAGAAGCAAATGCTTTTGAAGAAC
AACTATTAAAACAGAAAATGGATGAACTTCATAAGAAATTGCACCAAGTGGTGGAGCTGTCGCA
TGAGAACCCGCCTTCCTCCCAGGACAGGTCTGAGGTTAATCTAGCACAGGTAGGGCTGCATGCA
GGCTCCCTGCAGGAGCTCGGAGCACCGAGTCTACCAGCTGTCAATCAGCAGCCATCAAAGAATG
CAGGAGAGAAACCCAGGGAGGCACCTCCTGTTGTTCCTCTTACAACAAATGCTGTCACCGCTAC
TTTGGTGTCCCCAGCCATCAACCAGAGTGTAGCTCCCCTGGTTCTTCTGACAGCCCAACCAGTG
ACAGATACCATGTTTACAGTGACCGACAAAGCTGCCAGATGTATGAATCGAAGTACTCATGAAT
TCAAGCCACAGAATGGAGCAGAGATGAAAGAAGGGTGTGAAACACATAAGGTTGTTAATACAAG
TTCTTTTCACACCACTCCGAACACATCATTGGGACTGGTTCAGGCAACACCATCCAAAGTGCAG
CCATCCCCCACCGTGCACACAAAAGAAGCATTAGGTTTCATCATGAATATGTTTCAGGCTCCTA
CACTTCCTGATGTTTCCGATGACCAAGATGAATGGCCATCTCTAGGTCAAAATGAAGATGCTTT
TGAAGCCCAGTTTCAAATTTTTTACTCTGTTGCAGAAAATGCAAAGTCTTCTGGGGCTTGGGGA
GTCAATAAGATTATCTCTTCTTTGTCATCTGCTTTTCCCGTGTTTGAAGATGGAAACAAAGAAA
ATTATGGATTACCACAGCCTAAAAATAAACCCACAGGAGCCAGGACCTTTGGAGAACGCTCTGT
GAGCAGATTTCCTTCAAAACCAAATGAAGTACCTCACACAGAAGAATTTCTGGATGATTCAACC
GTATGGGGTCCCCGCTGCAACAAAACCCTGGCACCCAGTCCCAAGGGCCCCGGAGACTTCACGT
CTGCTGCACAGCTTGCGTCTACACCCTTCCACAAACTTCCAGTGGATTCAGTGCACCCTCTAGA
AGATAAAGAAAATGTGGTAGCAAAACAGTATACCCACATGACTTTGGATTCTTGTGAAAGAAAC
CTGGTGGAAACCTCGAAAGAAAGAAAGTTCAGTCCTATTCAAGAGAAAAGTCCAGAACTAGTGT
TCCCCACAGATGTCTCTTCAGCGTCCTTGCTCCGTCTGGGCCAGCCTGCTGCAGCTGTGCTGAC
CAGCGAGGCAGAGCAGGGCCTCAAGGCTTGTAAACTCACAGACCCCGCTGATCTTGCCACTGCA
GAGGATCCAACAGATGCCAGTGCCAGGCTCCAGGCAGAACAGATGCAGACTGGCTACCCTGGGC
ATGTCAGTGCTCCAGACTTCACTGTTGAGAATCCCTGGGACGAGGAGTTGATTCTCAAACTTTT
ATCCGGGCTTTCTAAGCCAGTGAGTTCCTATCCAAATATCTATGAGTGGCAGTGTAAACTTCCA
GCCATCAAGCCCAAGACTGAATTTCAATTGGGTTCTCTGGTGGTCTATATTGATCACCTTCTTG
GAGAAGGGGCTTTTGCCCAAGTCTATGAAGTTACCCACGGGGATGTGAACGATAACAAAAACAA
ACAGAAATTTGTTCTGAAGGTCCAGAAGCCTGCCAACCCCTGGGAATTCTACATTGGGACCCAG
CTCATGGAGAGACTAAAGCCAAGTATGCGGCACATGTTTATCAAATTCTATTCTGCCCACCTGT
TCCAGAATGGCAGTGTGTTAGTAGGAGATCTCTACAGCTACGGGACATTATTGAATGCCATTAA
CCTCTATAAAAATACCCCTGAGAAAGTGATGCCTCAAGCTCTAGTCCTCACTTTTGCCATCAGG
ATGCTCTGCATGATTGAACAAGTCCATGACTGTGAAATCATCCATGGAGACATCAAGCCAGACA
ACTTCATACTTGGAAACAGATTTTTGGAACAGGACGGTGAGGATGATGGCTTGGCACTGATTGA
CCTGGGTCAGAGTATAGACATGAAACTTTTTCCAAAAGGAACTGCATTTACGGGAAAGTGTGAA
ACATCTGGTTTTCAGTGTGTTGAGATGCTCAGTAACAGGCCCTGGAACTACCAGATTGATTACT
TTGGAGTTGCTGCGACAGTGTACTGCATGCTTTTTGGCACGTACATGAAAGTGAAAAATGAAGG
AGGGGTCTGGAAGCCTGAAGGTCTATTTAGAAGGCTTCCTCACTTGGATATGTGGAATGAATTT
TTTCACATAATGTTGAATATACCAGATTGTCATCATCTCCCACCTTTGGATTTAATAAGGCAGA
AGCTAAAGCAAGTATTTCAAGAACACTATGCAAACAAGATTAAGACCCTACGTAATAGGCTAAT
TGTACTACTCTTGGAATATAAGCGTTCTCGAAAATAAAATATGGACACTTCCTAAAACTCACTC
TGTAAATGCTGGCCTGCTCAAGTTGGACCTTGATGTTTCCACATTTATTATTTATGTAAATGTT
TCTTAAAAATAAAGTCCACAAAGTAGATCCA

hide sequence

RefSeq Acc Id:

XM_021087047 ⟹ XP_020942706

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	3	45,585,188 - 45,623,240 (+)	NCBI

Sequence:

show sequence

CTGGGAAACGCTCGTTGCAGCGACTGCGGCTGCGCGGCAGATTCGAATCGGCGGCGGCTCCTCC
ACAGCAGCGTAGTGGGGGGGTTCCGGCTGGCTCGCGTCCTCTCGCCATGGATAACCCGGAAAAT
GTCTTTCAAATGTTCGAAGCCCATATGCAGAGCTACAAGGGCGATGACCCACTTGGTGAATGGG
AAAGTTATGTGCGATGGGTAGAAGAGAATTTTCCTGAGAATAAAGAATACTTGACAACTTTATT
AGAGCATCTAATGAAGGAATTTTTAGATAAGAAGAGATACCACAGTGACCCAAGGTTCATCAAT
TATTGTTTAAAATTTGCCGAGTACAACAGTGACCTTCATCAGTTTTTTGAGTTTCTCCACAACC
ATGGTGTCGGGATCCGGTCAGCTCCTCTGTACATAGCCTGGGCTGGTCATCTGGAAGGCCAGGG
AGAATGGCAGCAAGCCAGCACTGTTTTTCACAGAGGAATTCAAAACCAGGCTGAACCTAGAGAG
CTGCTGCAACAGCAGTACAGGTTGTTTCAGACACGCCTTGCGGAAACCCATTTACCGACTCAAG
CGAGAATTTTAGAACCTCTGCATGATGCTCAGATTATAAACCAAATGGTAACATCAAAATCAAA
TCCAGGAAATAACTCAGCCTGTGTTTCTAAGAAGCAGGGTTCAGAGCTTTCTGGAGTAATATCT
TCAGCTTGTGATAAAGAGCCGAATATGGAACAGAGGGTGATCATGATTTCTAAATCAGAATATT
CTGCACACTCATCTTTGGCGGCCAAAACTGACATTCAGCAGGTTGTTATGTATTGCAAGGAGAA
GCTTATTTGTGGAGAATCAGAATTTTCCTTTGAAGAACTGAGAGCCCAGAAATACAATCAGCGG
AGGAAACATGAGCAATGGGTCCATGAAGACAGGCATTATATGAAAAGGAAAGAAGCAAATGCTT
TTGAAGAACAACTATTAAAACAGAAAATGGATGAACTTCATAAGAAATTGCACCAAGTGGTGGA
GCTGTCGCATGAGAACCCGCCTTCCTCCCAGGACAGGTCTGAGGTTAATCTAGCACAGGTAGGG
CTGCATGCAGGCTCCCTGCAGGAGCTCGGAGCACCGAGTCTACCAGCTGTCAATCAGCAGCCAT
CAAAGAATGCAGGAGAGAAACCCAGGGAGGCACCTCCTGTTGTTCCTCTTACAACAAATGCTGT
CACCGCTACTTTGGTGTCCCCAGCCATCAACCAGAGTGTAGCTCCCCTGGTTCTTCTGACAGCC
CAACCAGTGACAGATACCATGTTTACAGTGACCGACAAAGCTGCCAGATGTATGAATCGAAGTA
CTCATGAATTCAAGCCACAGAATGGAGCAGAGATGAAAGAAGGGTGTGAAACACATAAGGTTGT
TAATACAAGTTCTTTTCACACCACTCCGAACACATCATTGGGACTGGTTCAGGCAACACCATCC
AAAGTGCAGCCATCCCCCACCGTGCACACAAAAGAAGCATTAGGTTTCATCATGAATATGTTTC
AGGCTCCTACACTTCCTGATGTTTCCGATGACCAAGATGAATGGCCATCTCTAGGTCAAAATGA
AGATGCTTTTGAAGCCCAGTTTCAAAAAAATGCAAAGTCTTCTGGGGCTTGGGGAGTCAATAAG
ATTATCTCTTCTTTGTCATCTGCTTTTCCCGTGTTTGAAGATGGAAACAAAGAAAATTATGGAT
TACCACAGCCTAAAAATAAACCCACAGGAGCCAGGACCTTTGGAGAACGCTCTGTGAGCAGATT
TCCTTCAAAACCAAATGAAGTACCTCACACAGAAGAATTTCTGGATGATTCAACCGTATGGGGT
CCCCGCTGCAACAAAACCCTGGCACCCAGTCCCAAGGGCCCCGGAGACTTCACGTCTGCTGCAC
AGCTTGCGTCTACACCCTTCCACAAACTTCCAGTGGATTCAGTGCACCCTCTAGAAGATAAAGA
AAATGTGGTAGCAAAACAGTATACCCACATGACTTTGGATTCTTGTGAAAGAAACCTGGTGGAA
ACCTCGAAAGAAAGAAAGTTCAGTCCTATTCAAGAGAAAAGTCCAGAACTAGTGTTCCCCACAG
ATGTCTCTTCAGCGTCCTTGCTCCGTCTGGGCCAGCCTGCTGCAGCTGTGCTGACCAGCGAGGC
AGAGCAGGGCCTCAAGGCTTGTAAACTCACAGACCCCGCTGATCTTGCCACTGCAGAGGATCCA
ACAGATGCCAGTGCCAGGCTCCAGGCAGAACAGATGCAGACTGGCTACCCTGGGCATGTCAGTG
CTCCAGACTTCACTGTTGAGAATCCCTGGGACGAGGAGTTGATTCTCAAACTTTTATCCGGGCT
TTCTAAGCCAGTGAGTTCCTATCCAAATATCTATGAGTGGCAGTGTAAACTTCCAGCCATCAAG
CCCAAGACTGAATTTCAATTGGGTTCTCTGGTGGTCTATATTGATCACCTTCTTGGAGAAGGGG
CTTTTGCCCAAGTCTATGAAGTTACCCACGGGGATGTGAACGATAACAAAAACAAACAGAAATT
TGTTCTGAAGGTCCAGAAGCCTGCCAACCCCTGGGAATTCTACATTGGGACCCAGCTCATGGAG
AGACTAAAGCCAAGTATGCGGCACATGTTTATCAAATTCTATTCTGCCCACCTGTTCCAGAATG
GCAGTGTGTTAGTAGGAGATCTCTACAGCTACGGGACATTATTGAATGCCATTAACCTCTATAA
AAATACCCCTGAGAAAGTGATGCCTCAAGCTCTAGTCCTCACTTTTGCCATCAGGATGCTCTGC
ATGATTGAACAAGTCCATGACTGTGAAATCATCCATGGAGACATCAAGCCAGACAACTTCATAC
TTGGAAACAGATTTTTGGAACAGGACGGTGAGGATGATGGCTTGGCACTGATTGACCTGGGTCA
GAGTATAGACATGAAACTTTTTCCAAAAGGAACTGCATTTACGGGAAAGTGTGAAACATCTGGT
TTTCAGTGTGTTGAGATGCTCAGTAACAGGCCCTGGAACTACCAGATTGATTACTTTGGAGTTG
CTGCGACAGTGTACTGCATGCTTTTTGGCACGTACATGAAAGTGAAAAATGAAGGAGGGGTCTG
GAAGCCTGAAGGTCTATTTAGAAGGCTTCCTCACTTGGATATGTGGAATGAATTTTTTCACATA
ATGTTGAATATACCAGATTGTCATCATCTCCCACCTTTGGATTTAATAAGGCAGAAGCTAAAGC
AAGTATTTCAAGAACACTATGCAAACAAGATTAAGACCCTACGTAATAGGCTAATTGTACTACT
CTTGGAATATAAGCGTTCTCGAAAATAAAATATGGACACTTCCTAAAACTCACTCTGTAAATGC
TGGCCTGCTCAAGTTGGACCTTGATGTTTCCACATTTATTATTTATGTAAATGTTTCTTAAAAA
TAAAGTCCACAAAGTAGATCCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_020942705	(Get FASTA)	NCBI Sequence Viewer
	XP_020942706	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000026685
	ENSSSCP00000026685.2
	ENSSSCP00025047164.1
	ENSSSCP00035027712.1
	ENSSSCP00045017795.1
	ENSSSCP00055013768.1
	ENSSSCP00065037073.1
	ENSSSCP00070045399.1

RefSeq Acc Id:	XP_020942706 ⟸ XM_021087047
- Peptide Label:	isoform X2
- UniProtKB:	I3LRF1 (UniProtKB/TrEMBL), A0A4X1VPB3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDNPENVFQMFEAHMQSYKGDDPLGEWESYVRWVEENFPENKEYLTTLLEHLMKEFLDKKRYHS DPRFINYCLKFAEYNSDLHQFFEFLHNHGVGIRSAPLYIAWAGHLEGQGEWQQASTVFHRGIQN QAEPRELLQQQYRLFQTRLAETHLPTQARILEPLHDAQIINQMVTSKSNPGNNSACVSKKQGSE LSGVISSACDKEPNMEQRVIMISKSEYSAHSSLAAKTDIQQVVMYCKEKLICGESEFSFEELRA QKYNQRRKHEQWVHEDRHYMKRKEANAFEEQLLKQKMDELHKKLHQVVELSHENPPSSQDRSEV NLAQVGLHAGSLQELGAPSLPAVNQQPSKNAGEKPREAPPVVPLTTNAVTATLVSPAINQSVAP LVLLTAQPVTDTMFTVTDKAARCMNRSTHEFKPQNGAEMKEGCETHKVVNTSSFHTTPNTSLGL VQATPSKVQPSPTVHTKEALGFIMNMFQAPTLPDVSDDQDEWPSLGQNEDAFEAQFQKNAKSSG AWGVNKIISSLSSAFPVFEDGNKENYGLPQPKNKPTGARTFGERSVSRFPSKPNEVPHTEEFLD DSTVWGPRCNKTLAPSPKGPGDFTSAAQLASTPFHKLPVDSVHPLEDKENVVAKQYTHMTLDSC ERNLVETSKERKFSPIQEKSPELVFPTDVSSASLLRLGQPAAAVLTSEAEQGLKACKLTDPADL ATAEDPTDASARLQAEQMQTGYPGHVSAPDFTVENPWDEELILKLLSGLSKPVSSYPNIYEWQC KLPAIKPKTEFQLGSLVVYIDHLLGEGAFAQVYEVTHGDVNDNKNKQKFVLKVQKPANPWEFYI GTQLMERLKPSMRHMFIKFYSAHLFQNGSVLVGDLYSYGTLLNAINLYKNTPEKVMPQALVLTF AIRMLCMIEQVHDCEIIHGDIKPDNFILGNRFLEQDGEDDGLALIDLGQSIDMKLFPKGTAFTG KCETSGFQCVEMLSNRPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGVWKPEGLFRRLPHLDMW NEFFHIMLNIPDCHHLPPLDLIRQKLKQVFQEHYANKIKTLRNRLIVLLLEYKRSRK hide sequence

RefSeq Acc Id:	XP_020942705 ⟸ XM_021087046
- Peptide Label:	isoform X1
- UniProtKB:	A0A4X1VPB3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDNPENVFQMFEAHMQSYKGDDPLGEWESYVRWVEENFPENKEYLTTLLEHLMKEFLDKKRYHS DPRFINYCLKFAEYNSDLHQFFEFLHNHGVGIRSAPLYIAWAGHLEGQGEWQQASTVFHRGIQN QAEPRELLQQQYRLFQTRLAETHLPTQARILEPLHDAQIINQMVTSKSNPGNNSACVSKKQGSE LSGVISSACDKEPNMEQRVIMISKSEYSAHSSLAAKTDIQQVVMYCKEKLICGESEFSFEELRA QKYNQRRKHEQWVHEDRHYMKRKEANAFEEQLLKQKMDELHKKLHQVVELSHENPPSSQDRSEV NLAQVGLHAGSLQELGAPSLPAVNQQPSKNAGEKPREAPPVVPLTTNAVTATLVSPAINQSVAP LVLLTAQPVTDTMFTVTDKAARCMNRSTHEFKPQNGAEMKEGCETHKVVNTSSFHTTPNTSLGL VQATPSKVQPSPTVHTKEALGFIMNMFQAPTLPDVSDDQDEWPSLGQNEDAFEAQFQIFYSVAE NAKSSGAWGVNKIISSLSSAFPVFEDGNKENYGLPQPKNKPTGARTFGERSVSRFPSKPNEVPH TEEFLDDSTVWGPRCNKTLAPSPKGPGDFTSAAQLASTPFHKLPVDSVHPLEDKENVVAKQYTH MTLDSCERNLVETSKERKFSPIQEKSPELVFPTDVSSASLLRLGQPAAAVLTSEAEQGLKACKL TDPADLATAEDPTDASARLQAEQMQTGYPGHVSAPDFTVENPWDEELILKLLSGLSKPVSSYPN IYEWQCKLPAIKPKTEFQLGSLVVYIDHLLGEGAFAQVYEVTHGDVNDNKNKQKFVLKVQKPAN PWEFYIGTQLMERLKPSMRHMFIKFYSAHLFQNGSVLVGDLYSYGTLLNAINLYKNTPEKVMPQ ALVLTFAIRMLCMIEQVHDCEIIHGDIKPDNFILGNRFLEQDGEDDGLALIDLGQSIDMKLFPK GTAFTGKCETSGFQCVEMLSNRPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGVWKPEGLFRRL PHLDMWNEFFHIMLNIPDCHHLPPLDLIRQKLKQVFQEHYANKIKTLRNRLIVLLLEYKRSRK hide sequence

RefSeq Acc Id:

ENSSSCP00000026685 ⟸ ENSSSCT00000025163

RefSeq Acc Id:

ENSSSCP00000072094 ⟸ ENSSSCT00000079878

RefSeq Acc Id:

ENSSSCP00000065793 ⟸ ENSSSCT00000066450

RefSeq Acc Id:

ENSSSCP00000064616 ⟸ ENSSSCT00000071948

Protein Domains

BUB1 N-terminal Protein kinase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000030469	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00025076207	UniProtKB/TrEMBL
	ENSSSCG00035051369	UniProtKB/TrEMBL
	ENSSSCG00045015139	UniProtKB/TrEMBL
	ENSSSCG00055008854	UniProtKB/TrEMBL
	ENSSSCG00065061899	UniProtKB/TrEMBL
	ENSSSCG00070026612	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000025163	ENTREZGENE
	ENSSSCT00000025163.3	UniProtKB/TrEMBL
	ENSSSCT00025105498.1	UniProtKB/TrEMBL
	ENSSSCT00035068429.1	UniProtKB/TrEMBL
	ENSSSCT00045025793.1	UniProtKB/TrEMBL
	ENSSSCT00055017413.1	UniProtKB/TrEMBL
	ENSSSCT00065084903.1	UniProtKB/TrEMBL
	ENSSSCT00070053555.1	UniProtKB/TrEMBL
Gene3D-CATH	1.25.40.430	UniProtKB/TrEMBL
	6.10.130.20	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	Bub1/Mad3	UniProtKB/TrEMBL
	Kinase-like_dom_sf	UniProtKB/TrEMBL
	Mad3/Bub1_I	UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	Ser/Thr_kinase_AS	UniProtKB/TrEMBL
NCBI Gene	BUB1	ENTREZGENE
PANTHER	MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1	UniProtKB/TrEMBL
	PTHR14030	UniProtKB/TrEMBL
Pfam	Mad3_BUB1_I	UniProtKB/TrEMBL
	Pkinase	UniProtKB/TrEMBL
PROSITE	BUB1_N	UniProtKB/TrEMBL
	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/TrEMBL
SMART	Mad3_BUB1_I	UniProtKB/TrEMBL
	S_TKc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56112	UniProtKB/TrEMBL
UniProt	A0A4X1VPB3	ENTREZGENE, UniProtKB/TrEMBL
	I3LRF1	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:85918	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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