Bub1 (BUB1, mitotic checkpoint serine/threonine kinase) - Rat Genome Database

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Gene: Bub1 (BUB1, mitotic checkpoint serine/threonine kinase) Mus musculus
Analyze
Symbol: Bub1
Name: BUB1, mitotic checkpoint serine/threonine kinase
RGD ID: 1323305
MGI Page MGI
Description: Predicted to enable protein kinase activity. Acts upstream of or within chromosome segregation and positive regulation of intrinsic apoptotic signaling pathway. Located in kinetochore. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human BUB1 (BUB1 mitotic checkpoint serine/threonine kinase); PARTICIPATES IN cell cycle pathway, mitotic; INTERACTS WITH (S)-amphetamine; 1,1-dichloroethene; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AL022991; Bub1a; budding uninhibited by benzimidazoles 1 homolog; C80208; D2Xrf8; D2Xrf87; mBUB1; mitotic checkpoint serine/threonine-protein kinase BUB1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392127,642,117 - 127,673,790 (-)NCBIGRCm39mm39
GRCm39 Ensembl2127,643,042 - 127,673,785 (-)Ensembl
GRCm382127,800,197 - 127,831,859 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2127,801,122 - 127,831,865 (-)EnsemblGRCm38mm10GRCm38
MGSCv372127,625,936 - 127,657,595 (-)NCBIGRCm37mm9NCBIm37
MGSCv362127,492,562 - 127,523,236 (-)NCBImm8
Celera2129,026,419 - 129,058,592 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map262.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-amphetamine  (EXP)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3-methylcholanthrene  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP,ISO)
4-hydroxynon-2-enal  (EXP)
4-nitroquinoline N-oxide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amosite asbestos  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsenite(3-)  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (ISO)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP)
choline  (EXP)
chromium(6+)  (EXP,ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cryptolepine  (ISO)
Cuprizon  (ISO)
cyclosporin A  (EXP,ISO)
dichloroacetic acid  (EXP)
dicrotophos  (ISO)
doxorubicin  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
eugenol  (ISO)
fluvastatin  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (ISO)
genistein  (ISO)
geraniol  (ISO)
GW 4064  (ISO)
hydrogen peroxide  (ISO)
irinotecan  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP)
leflunomide  (ISO)
lucanthone  (ISO)
malathion  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nocodazole  (ISO)
O-methyleugenol  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (EXP)
perfluorononanoic acid  (ISO)
phenformin  (ISO)
phenobarbital  (EXP)
PhIP  (ISO)
picoxystrobin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP)
piroxicam  (ISO)
potassium chromate  (ISO)
promethazine  (ISO)
propanal  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
silicon dioxide  (EXP)
silver(1+) nitrate  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
toluene 2,4-diisocyanate  (EXP)
topotecan  (ISO)
Tributyltin oxide  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal cell cycle  (IAGP)
abnormal cell cycle checkpoint function  (IAGP)
abnormal cell death  (IAGP)
abnormal mitosis  (IAGP)
abnormal mitotic spindle assembly checkpoint  (IAGP)
abnormal mitotic spindle morphology  (IAGP)
abnormal spermatogenesis  (IAGP)
anemia  (IAGP)
aneuploidy  (IAGP)
chromosomal instability  (IAGP)
decreased birth weight  (IAGP)
decreased cell proliferation  (IAGP)
decreased fetal size  (IAGP)
decreased fibroblast apoptosis  (IAGP)
decreased fibroblast proliferation  (IAGP)
decreased litter size  (IAGP)
decreased mitotic index  (IAGP)
decreased startle reflex  (IEA)
decreased testis weight  (IAGP)
decreased tumor incidence  (IAGP)
decreased tumor latency  (IAGP)
early cellular replicative senescence  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality prior to organogenesis  (IEA)
embryonic lethality, complete penetrance  (IAGP)
fetal growth retardation  (IAGP)
hepatic necrosis  (IAGP)
increased brain tumor incidence  (IAGP)
increased hepatocellular carcinoma incidence  (IAGP)
increased incidence of induced tumors  (IAGP)
increased incidence of tumors by chemical induction  (IAGP)
increased leukocyte cell number  (IAGP)
increased liver tumor incidence  (IAGP)
increased lung tumor incidence  (IAGP)
increased lymphoma incidence  (IAGP)
increased sarcoma incidence  (IAGP)
male infertility  (IAGP)
maternal effect  (IAGP)
no abnormal phenotype detected  (IAGP)
oligozoospermia  (IAGP)
pale liver  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
reduced male fertility  (IAGP)
small seminiferous tubules  (IAGP)
small testis  (IAGP)
References

Additional References at PubMed
PMID:7482790   PMID:7671812   PMID:8000140   PMID:9182760   PMID:9441741   PMID:9889005   PMID:10349636   PMID:10411903   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11352911  
PMID:12355205   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273   PMID:14646599   PMID:14681479   PMID:15226446   PMID:15611331   PMID:16141072   PMID:16141073   PMID:16595651  
PMID:16969117   PMID:17227893   PMID:17925231   PMID:17938250   PMID:18084284   PMID:18753610   PMID:18799693   PMID:19117986   PMID:19249208   PMID:19617567   PMID:19772675   PMID:19962666  
PMID:19965387   PMID:20124418   PMID:20360068   PMID:20663956   PMID:20729907   PMID:21267068   PMID:21440680   PMID:21646403   PMID:21873635   PMID:22331848   PMID:23209306   PMID:23242215  
PMID:26031201   PMID:26410627   PMID:26496610   PMID:27694478   PMID:28705898   PMID:28947820   PMID:29608549   PMID:31693903   PMID:32232159   PMID:32325033   PMID:32758484  


Genomics

Comparative Map Data
Bub1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392127,642,117 - 127,673,790 (-)NCBIGRCm39mm39
GRCm39 Ensembl2127,643,042 - 127,673,785 (-)Ensembl
GRCm382127,800,197 - 127,831,859 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2127,801,122 - 127,831,865 (-)EnsemblGRCm38mm10GRCm38
MGSCv372127,625,936 - 127,657,595 (-)NCBIGRCm37mm9NCBIm37
MGSCv362127,492,562 - 127,523,236 (-)NCBImm8
Celera2129,026,419 - 129,058,592 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map262.1NCBI
BUB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2110,637,528 - 110,678,063 (-)EnsemblGRCh38hg38GRCh38
GRCh382110,637,528 - 110,678,063 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372111,395,105 - 111,435,640 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362111,111,881 - 111,152,135 (-)NCBINCBI36hg18NCBI36
Build 342111,111,642 - 111,151,895NCBI
Celera2105,046,046 - 105,086,323 (-)NCBI
Cytogenetic Map2q13NCBI
HuRef2104,274,404 - 104,314,815 (-)NCBIHuRef
CHM1_12111,399,569 - 111,439,978 (-)NCBICHM1_1
Bub1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23115,020,254 - 115,051,650 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl3115,020,254 - 115,051,650 (-)Ensembl
Rnor_6.03120,373,604 - 120,404,910 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3120,373,604 - 120,404,910 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03126,929,123 - 126,960,429 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43115,323,510 - 115,354,906 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13115,230,064 - 115,260,294 (-)NCBI
Celera3113,854,710 - 113,886,108 (-)NCBICelera
Cytogenetic Map3q36NCBI
Bub1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554703,152,758 - 3,191,888 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554703,152,798 - 3,190,185 (+)NCBIChiLan1.0ChiLan1.0
BUB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A111,815,335 - 111,855,573 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A111,793,236 - 111,858,392 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A91,393,317 - 91,433,579 (-)NCBIMhudiblu_PPA_v0panPan3
BUB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11735,208,989 - 35,252,296 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1735,208,991 - 35,252,975 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1734,978,541 - 35,021,465 (-)NCBI
ROS_Cfam_1.01735,980,361 - 36,023,634 (-)NCBI
UMICH_Zoey_3.11735,107,041 - 35,149,998 (-)NCBI
UNSW_CanFamBas_1.01735,176,457 - 35,219,422 (-)NCBI
UU_Cfam_GSD_1.01735,386,576 - 35,429,599 (-)NCBI
BUB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl345,585,226 - 45,624,543 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1345,585,188 - 45,623,240 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2347,568,892 - 47,584,217 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BUB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11413,647,342 - 13,698,061 (+)NCBI
ChlSab1.1 Ensembl1413,647,462 - 13,697,932 (+)Ensembl
Vero_WHO_p1.0NW_0236660805,994,677 - 6,036,649 (-)NCBI
Bub1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247491,584,289 - 1,639,334 (+)NCBI

Position Markers
RH125393  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382127,807,859 - 127,807,940UniSTSGRCm38
MGSCv372127,633,595 - 127,633,676UniSTSGRCm37
Celera2129,034,364 - 129,034,445UniSTS
Cytogenetic Map2F1UniSTS
cM Map273.0UniSTS
Bub1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2F1UniSTS
cM Map273.0UniSTS
cM Map273.0UniSTS
RH126827  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3814124,498,042 - 124,498,246UniSTSGRCm38
GRCm382127,800,331 - 127,800,535UniSTSGRCm38
MGSCv3714124,897,264 - 124,897,468UniSTSGRCm37
MGSCv372127,626,067 - 127,626,271UniSTSGRCm37
Celera2129,026,550 - 129,026,754UniSTS
Cytogenetic Map14E5UniSTS
Cytogenetic Map2F1UniSTS
cM Map273.0UniSTS
cM Map1459.0UniSTS
Whitehead/MRC_RH21588.23UniSTS
Bub1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2F1UniSTS
cM Map273.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301755Hrq1_mheart rate quantitative locus 1 (mouse)Not determined2111331784145331901Mouse
1301822Pgia2_mproteoglycan induced arthritis 2 (mouse)Not determined2124095391158095504Mouse
1301825Pbrgcsf1_mperipheral blood stem cell response to granulocyte colony stimulating factor 1 (mouse)Not determined2106391660140391809Mouse
1301415Actre4_mactivity response to ethanol 4 (mouse)Not determined2112194642128331901Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2118112449174483070Mouse
1302143Bwq5_mbody weight (mouse)Not determined2127822099161822198Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224334620148858457Mouse
1302033Nsv1_mNeuroadapted Sindbis viral RNA level 1 (mouse)Not determined2111781466145781606Mouse
1302071Fembrs1_mfemur breaking strength 1 (mouse)Not determined2101112449135112609Mouse
1302203Gvhd3_mgraft-versus host disease 3 (mouse)Not determined2101112449135112609Mouse
1300793Pcfm2_mperiosteal circumference and femur length 2 (mouse)Not determined2111331784145331901Mouse
1300798Actre3_mactivity response to ethanol 3 (mouse)Not determined2112194642128331901Mouse
1301905Lgth2_mbody length 2 (mouse)Not determined2111331784145331901Mouse
1558990Skmw9_mskeletal muscle weight 9 (mouse)Not determined2111331784145331901Mouse
1300712El2_mepilepsy 2 (mouse)Not determined2122376665142690215Mouse
1301029T2dm3_mtype 2 diabetes mellitus 3 (mouse)Not determined2114457594132872237Mouse
1301031Bdln3_mbody length 3 (mouse)Not determined2127822099161822198Mouse
1558881Ses7_msalmonella enteritidis susceptibility 7 (mouse)Not determined2116464410150464554Mouse
1301066Otx2m2_morthodenticle homolog 2 (Drosophila) modifier 2 (mouse)Not determined2123390053148858457Mouse
1301330Tbbmd2_mtotal body bone mineral density 2 (mouse)Not determined2101112449135112609Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245457623145470727Mouse
1301201Chab1_mcholesterol absorption 1 (mouse)Not determined2111709108145709243Mouse
1301087Bbaa15_mB.burgdorferi-associated arthritis 15 (mouse)Not determined2110647738144647887Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284182854148680255Mouse
1301294Hrtfm5_mheart failure modifier 5 (mouse)Not determined2123041095157041211Mouse
1301295Prdt1_mprion disease incubation time 1 (mouse)Not determined2116235703150235821Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285893925181254801Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265439402162677006Mouse
10043875Bw25_mbody weight QTL 25 (mouse)Not determined2107413756141413756Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284182854148825550Mouse
10045885Cplaq15_mcircadian period of locomotor activity 15 (mouse)Not determined2111085773154512747Mouse
4141802Ignpq1_mIgA nephropathy QTL 1 (mouse)Not determined2100993579134993788Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229417935148533014Mouse
12910799Pwgrq2_mpre-weaning growth rate QTL 2 (mouse)2118758772160769245Mouse
11039521Ltpr2g_mLeishmania tropica response 2g (mouse)2115370937149371074Mouse
11039520Ltpr2h_mLeishmania tropica response 2h (mouse)2112370826146371085Mouse
11041906Lmr28a_mleishmaniasis resistance 28a (mouse)2103265371129371085Mouse
13506763Tbvq1_mtrabecular bone volume QTL 1 (mouse)2126200000135600000Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102800000160100000Mouse
11049568Lmr28c_mleishmaniasis resistance 28c (mouse)297292889131293051Mouse
11038696Ltpr2f_mLeishmania tropica response 2f (mouse)2115370937149371074Mouse
12910795Pwbwq5_mpost-weaning body weight QTL 5 (mouse)2118758772160769245Mouse
11049569Lmr28d_mleishmaniasis resistance 28d (mouse)297292889131293051Mouse
11528549Sluc31_msusceptibility to lung cancer 31 (mouse)274693773129371085Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294400000154400000Mouse
12910814Pwbwq1_mpre-weaning body weight QTL 1 (mouse)2118758772160769245Mouse
12910812Pwgrq1_mpre-weaning growth rate QTL 1 (mouse)2118758772160769245Mouse
12904954Gmmq2_mgastrocnemius muscle mass QTL 2 (mouse)297379883131379883Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)262000000137000000Mouse
12904935Edlmmq2_mextensor digitorum longus muscle mass QTL 2 (mouse)297379883131379883Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124600000168400000Mouse
11038699Ltpr2b_mLeishmania tropica response 2b (mouse)2112370826146371085Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103265371167370436Mouse
11038700Ltpr2a_mLeishmania tropica response 2a (mouse)2112370826146371085Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir10bmmu-miR-10b-3pOncomiRDBexternal_infoNANA23125021
Mir10ammu-miR-10a-3pOncomiRDBexternal_infoNANA23125021

Predicted Target Of
Summary Value
Count of predictions:303
Count of miRNA genes:245
Interacting mature miRNAs:272
Transcripts:ENSMUST00000028858, ENSMUST00000133943, ENSMUST00000138624, ENSMUST00000143824, ENSMUST00000153048
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000028858   ⟹   ENSMUSP00000028858
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2127,643,042 - 127,673,785 (-)Ensembl
GRCm38.p6 Ensembl2127,801,122 - 127,831,865 (-)Ensembl
RefSeq Acc Id: ENSMUST00000133943
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2127,665,368 - 127,673,724 (-)Ensembl
GRCm38.p6 Ensembl2127,823,448 - 127,831,804 (-)Ensembl
RefSeq Acc Id: ENSMUST00000138624
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2127,646,424 - 127,647,186 (-)Ensembl
GRCm38.p6 Ensembl2127,804,504 - 127,805,266 (-)Ensembl
RefSeq Acc Id: ENSMUST00000143824
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2127,652,457 - 127,656,830 (-)Ensembl
GRCm38.p6 Ensembl2127,810,537 - 127,814,910 (-)Ensembl
RefSeq Acc Id: ENSMUST00000153048
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2127,650,833 - 127,655,787 (-)Ensembl
GRCm38.p6 Ensembl2127,808,913 - 127,813,867 (-)Ensembl
RefSeq Acc Id: NM_001113179   ⟹   NP_001106650
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392127,642,120 - 127,673,779 (-)NCBI
GRCm382127,800,200 - 127,831,859 (-)NCBI
MGSCv372127,625,936 - 127,657,595 (-)RGD
Celera2129,026,419 - 129,058,592 (-)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_009772   ⟹   NP_033902
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392127,642,120 - 127,673,779 (-)NCBI
GRCm382127,800,200 - 127,831,859 (-)NCBI
MGSCv372127,625,936 - 127,657,595 (-)RGD
Celera2129,026,419 - 129,058,592 (-)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006498620   ⟹   XP_006498683
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392127,642,117 - 127,673,790 (-)NCBI
GRCm382127,800,197 - 127,831,859 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036157774   ⟹   XP_036013667
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392127,642,117 - 127,673,790 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_033902   ⟸   NM_009772
- Peptide Label: isoform 2
- UniProtKB: O08901 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001106650   ⟸   NM_001113179
- Peptide Label: isoform 1
- UniProtKB: O08901 (UniProtKB/Swiss-Prot),   A2APR8 (UniProtKB/TrEMBL),   Q8K1K8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006498683   ⟸   XM_006498620
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000028858   ⟸   ENSMUST00000028858
RefSeq Acc Id: XP_036013667   ⟸   XM_036157774
- Peptide Label: isoform X2
Protein Domains
BUB1 N-terminal   Protein kinase

Promoters
RGD ID:6830923
Promoter ID:MM_KWN:31627
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell
Transcripts:NM_009772,   OTTMUST00000038446,   OTTMUST00000038447
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362127,657,219 - 127,657,719 (-)MPROMDB
RGD ID:6878694
Promoter ID:EPDNEW_M2787
Type:multiple initiation site
Name:Bub1_1
Description:Mus musculus BUB1, mitotic checkpoint serine/threonine kinase, transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382127,831,848 - 127,831,908EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1100510 AgrOrtholog
Ensembl Genes ENSMUSG00000027379 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000028858 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000028858 ENTREZGENE, UniProtKB/TrEMBL
InterPro Bub1/Mad3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mad3/Bub1_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12235 UniProtKB/Swiss-Prot
MGD MGI:1100510 ENTREZGENE
NCBI Gene 12235 ENTREZGENE
PANTHER PTHR14030 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Mad3_BUB1_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bub1 PhenoGen
PROSITE BUB1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Mad3_BUB1_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2APR8 ENTREZGENE, UniProtKB/TrEMBL
  BUB1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8C4D0_MOUSE UniProtKB/TrEMBL
  Q8K1K8 ENTREZGENE, UniProtKB/TrEMBL
  Q9CS10_MOUSE UniProtKB/TrEMBL
UniProt Secondary O09007 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-22 Bub1  BUB1, mitotic checkpoint serine/threonine kinase    budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)  Symbol and/or name change 5135510 APPROVED