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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chlorhexidine
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Accession:CHEBI:3614 term browser browse the term
Definition:A bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge.
Synonyms:exact_synonym: N',N'''''-hexane-1,6-diylbis[N-(4-chlorophenyl)(imidodicarbonimidic diamide)]
 related_synonym: 1,1'-Hexamethylene bis(5-(p-chlorophenyl)biguanide);   Formula=C22H30Cl2N10;   InChI=1S/C22H30Cl2N10/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);   InChIKey=GHXZTYHSJHQHIJ-UHFFFAOYSA-N;   N,N'-Bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide;   SMILES=Clc1ccc(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)Nc2ccc(Cl)cc2)cc1
 xref: Beilstein:2826432;   CAS:55-56-1;   DrugBank:DB00878;   Drug_Central:597;   KEGG:C06902;   KEGG:D07668;   LINCS:LSM-5633
 xref_mesh: MESH:D002710
 xref: PMID:10848923;   PMID:11564456;   PMID:16238008;   PMID:17602516;   PMID:24384684;   PMID:33786648;   PMID:33805369;   PMID:33850179;   PMID:33863402;   Reaxys:2826432;   VSDB:1779;   Wikipedia:Chlorhexidine


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chlorhexidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Chlorhexidine results in increased expression of HSPA5 protein CTD PMID:19027770 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Iyd iodotyrosine deiodinase multiple interactions ISO Chlorhexidine inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] CTD PMID:33352258 NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Chlorhexidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
chlorhexidine gluconate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpt glutamic--pyruvic transaminase increases secretion EXP chlorhexidine gluconate results in increased secretion of GPT protein CTD PMID:145039 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        antimicrobial agent 17400
          antibacterial agent 13566
            chlorhexidine 4
              chlorhexidine acetate 0
              chlorhexidine gluconate 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic molecule 19560
                              organic cyclic compound 19351
                                carbocyclic compound 18309
                                  benzenoid aromatic compound 17453
                                    benzenes 17233
                                      chlorobenzenes 13608
                                        monochlorobenzenes 9752
                                          chlorhexidine 4
                                            chlorhexidine acetate 0
                                            chlorhexidine gluconate 1
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