Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chlorhexidine
go back to main search page
Accession:CHEBI:3614 term browser browse the term
Definition:A bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge.
Synonyms:exact_synonym: N',N'''''-hexane-1,6-diylbis[N-(4-chlorophenyl)(imidodicarbonimidic diamide)]
 related_synonym: 1,1'-Hexamethylene bis(5-(p-chlorophenyl)biguanide);   Formula=C22H30Cl2N10;   InChI=1S/C22H30Cl2N10/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);   InChIKey=GHXZTYHSJHQHIJ-UHFFFAOYSA-N;   N,N'-Bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide;   SMILES=Clc1ccc(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)Nc2ccc(Cl)cc2)cc1
 xref: Beilstein:2826432;   CAS:55-56-1;   DrugBank:DB00878;   Drug_Central:597;   KEGG:C06902;   KEGG:D07668;   LINCS:LSM-5633
 xref_mesh: MESH:D002710
 xref: PMID:10848923;   PMID:11564456;   PMID:16238008;   PMID:17602516;   PMID:24384684;   PMID:33786648;   PMID:33805369;   PMID:33850179;   PMID:33863402;   Reaxys:2826432;   VSDB:1779;   Wikipedia:Chlorhexidine



show annotations for term's descendants           Sort by:
 
chlorhexidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Chlorhexidine results in decreased activity of ACHE protein CTD PMID:33844597 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Chlorhexidine results in increased expression of HSPA5 protein CTD PMID:19027770 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Iyd iodotyrosine deiodinase multiple interactions ISO Chlorhexidine inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] CTD PMID:33352258 NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Chlorhexidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
chlorhexidine gluconate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpt glutamic--pyruvic transaminase increases secretion EXP chlorhexidine gluconate results in increased secretion of GPT protein CTD PMID:145039 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      biological role 20011
        antimicrobial agent 17818
          antibacterial agent 14324
            chlorhexidine 5
              chlorhexidine acetate 0
              chlorhexidine gluconate 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic molecule 19856
                              organic cyclic compound 19612
                                carbocyclic compound 18542
                                  benzenoid aromatic compound 17766
                                    benzenes 17590
                                      chlorobenzenes 13873
                                        monochlorobenzenes 9902
                                          chlorhexidine 5
                                            chlorhexidine acetate 0
                                            chlorhexidine gluconate 1
paths to the root