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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chlorhexidine
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Accession:CHEBI:3614 term browser browse the term
Definition:A bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge.
Synonyms:exact_synonym: N',N'''''-hexane-1,6-diylbis[N-(4-chlorophenyl)(imidodicarbonimidic diamide)]
 related_synonym: 1,1'-Hexamethylene bis(5-(p-chlorophenyl)biguanide);   Formula=C22H30Cl2N10;   InChI=1S/C22H30Cl2N10/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);   InChIKey=GHXZTYHSJHQHIJ-UHFFFAOYSA-N;   N,N'-Bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide;   SMILES=Clc1ccc(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)Nc2ccc(Cl)cc2)cc1
 xref: Beilstein:2826432;   CAS:55-56-1;   DrugBank:DB00878;   Drug_Central:597;   KEGG:C06902;   KEGG:D07668;   LINCS:LSM-5633
 xref_mesh: MESH:D002710
 xref: PMID:10848923;   PMID:11564456;   PMID:16238008;   PMID:17602516;   PMID:24384684;   Reaxys:2826432;   VSDB:1779;   Wikipedia:Chlorhexidine


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chlorhexidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Chlorhexidine results in increased expression of HSPA5 protein CTD PMID:19027770 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Chlorhexidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
chlorhexidine gluconate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpt glutamic--pyruvic transaminase increases secretion EXP chlorhexidine gluconate results in increased secretion of GPT protein CTD PMID:145039 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        antimicrobial agent 17309
          antibacterial agent 13019
            chlorhexidine 3
              chlorhexidine gluconate 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                carbocyclic compound 18181
                                  benzenoid aromatic compound 17178
                                    benzenes 16920
                                      chlorobenzenes 12990
                                        monochlorobenzenes 8871
                                          chlorhexidine 3
                                            chlorhexidine gluconate 1
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