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Gene: Pfkfb1 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1) Rattus norvegicus
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Symbol: Pfkfb1
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
Description: Exhibits several functions, including 6-phosphofructo-2-kinase activity; anion binding activity; and fructose-2,6-bisphosphate 2-phosphatase activity. Involved in several processes, including positive regulation of glucokinase activity; response to cAMP; and response to peptide hormone. Localizes to the 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex. Biomarker of hyperinsulinism. Orthologous to human PFKFB1 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1); PARTICIPATES IN fructose and mannose metabolic pathway; fructosuria pathway; hereditary fructose intolerance syndrome pathway; INTERACTS WITH 2,3,4,7,8-Pentachlorodibenzofuran; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 6-PF2-K/Fru-2,6-P2ase; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1; 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (liver and muscle); 6-phosphofructo-2-kinase/fructose-26-bisphosphatase 1; 6-Phosphofructo-2-kinase/fructose-26-bisphosphatase 1 (liver and muscle); 6PF-2-K/Fru-2,6-P2ase 1; 6PF-2-K/Fru-2,6-P2ASE liver isozyme; PFK/FBPase 1; PFK2/FBPase2; Pfkfb01; PFRX
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0X23,092,143 - 23,145,923 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X23,512,672 - 23,564,431 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X39,838,471 - 39,886,071 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X39,891,912 - 39,939,574 (+)NCBI
CeleraX19,781,360 - 19,833,302 (+)NCBICelera
Cytogenetic MapXq13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Pfkfb1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3307
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.