Arhgef10 (Rho guanine nucleotide exchange factor 10) - Rat Genome Database
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Gene: Arhgef10 (Rho guanine nucleotide exchange factor 10) Rattus norvegicus
Analyze
Symbol: Arhgef10
Name: Rho guanine nucleotide exchange factor 10
RGD ID: 1565043
Description: Predicted to have guanyl-nucleotide exchange factor activity and kinesin binding activity. Predicted to be involved in several processes, including activation of GTPase activity; microtubule cytoskeleton organization; and positive regulation of stress fiber assembly. Predicted to localize to centrosome. Orthologous to human ARHGEF10 (Rho guanine nucleotide exchange factor 10); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; bisphenol A; Brodifacoum.
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC306618; RGD1565043; Rho guanine nucleotide exchange factor (GEF) 10; similar to Rho guanine nucleotide exchange factor (GEF) 10
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21674,647,147 - 74,738,784 (-)NCBI
Rnor_6.0 Ensembl1679,725,643 - 79,793,619 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01679,725,629 - 79,817,065 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01679,302,340 - 79,392,426 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41679,458,304 - 79,547,225 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1672,465,044 - 72,554,359 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (IBA,ISO)
cytosol  (IEA)

Molecular Function

References

Additional References at PubMed
PMID:14508709   PMID:16896804   PMID:19635168   PMID:20042462  


Genomics

Comparative Map Data
Arhgef10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21674,647,147 - 74,738,784 (-)NCBI
Rnor_6.0 Ensembl1679,725,643 - 79,793,619 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01679,725,629 - 79,817,065 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01679,302,340 - 79,392,426 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41679,458,304 - 79,547,225 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1672,465,044 - 72,554,359 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
ARHGEF10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl81,823,926 - 1,958,641 (+)EnsemblGRCh38hg38GRCh38
GRCh3881,823,926 - 1,958,641 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3781,772,092 - 1,906,807 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3681,759,556 - 1,894,214 (+)NCBINCBI36hg18NCBI36
Build 3481,808,165 - 1,894,206NCBI
Celera81,715,545 - 1,849,273 (+)NCBI
Cytogenetic Map8p23.3NCBI
HuRef81,586,197 - 1,723,095 (+)NCBIHuRef
CHM1_181,772,104 - 1,906,332 (+)NCBICHM1_1
Arhgef10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39814,956,405 - 15,051,085 (+)NCBIGRCm39mm39
GRCm39 Ensembl814,961,663 - 15,051,085 (+)Ensembl
GRCm38814,906,412 - 15,001,085 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl814,911,663 - 15,001,085 (+)EnsemblGRCm38mm10GRCm38
MGSCv37814,911,717 - 15,001,085 (+)NCBIGRCm37mm9NCBIm37
MGSCv36814,928,877 - 15,000,415 (+)NCBImm8
Celera815,075,995 - 15,165,401 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
Arhgef10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540357,818,837 - 57,907,324 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540357,820,003 - 57,907,324 (-)NCBIChiLan1.0ChiLan1.0
ARHGEF10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.181,747,801 - 1,862,917 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl81,724,413 - 1,862,917 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v085,381,357 - 5,541,094 (-)NCBIMhudiblu_PPA_v0panPan3
ARHGEF10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1654,293,435 - 54,347,555 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11654,293,534 - 54,378,706 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Arhgef10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366151,012,009 - 1,103,468 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGEF10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11533,370,093 - 33,465,852 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21537,931,757 - 37,986,440 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGEF10
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.181,487,076 - 1,620,387 (+)NCBI
ChlSab1.1 Ensembl81,502,226 - 1,620,389 (+)Ensembl
Arhgef10
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624861992,824 - 1,083,048 (+)NCBI

Position Markers
RH131116  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01679,725,761 - 79,725,945NCBIRnor6.0
Rnor_5.01679,302,472 - 79,302,656UniSTSRnor5.0
RGSC_v3.41679,457,269 - 79,457,453UniSTSRGSC3.4
Celera1672,465,176 - 72,465,360UniSTS
RH 3.4 Map16727.9UniSTS
Cytogenetic Map16q12.5UniSTS
RH136741  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01679,739,746 - 79,739,868NCBIRnor6.0
Rnor_5.01679,316,021 - 79,316,143UniSTSRnor5.0
RGSC_v3.41679,473,578 - 79,473,700UniSTSRGSC3.4
Celera1672,477,491 - 72,477,613UniSTS
Cytogenetic Map16q12.5UniSTS
AW533825  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01679,774,144 - 79,774,301NCBIRnor6.0
Rnor_5.01679,350,419 - 79,350,576UniSTSRnor5.0
Celera1672,511,895 - 72,512,052UniSTS
RH 3.4 Map16728.8UniSTS
Cytogenetic Map16q12.5UniSTS
ha2626  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.013112,477,086 - 112,478,466NCBIRnor6.0
Rnor_5.013117,027,835 - 117,029,215UniSTSRnor5.0
RGSC_v3.413109,613,020 - 109,614,400UniSTSRGSC3.4
Celera1672,530,738 - 72,530,895UniSTS
Celera13104,704,330 - 104,705,710UniSTS
Cytogenetic Map16q12.5UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)16109005486162972Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)162075555680316424Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163900002184000021Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)164151271086512710Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)164151271086512710Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164655818890668790Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165781635790668790Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165781635790668790Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165781635790668790Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165928577589248943Rat
1298527Arunc2Aerobic running capacity QTL 22.9exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)167321963880115794Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:125
Count of miRNA genes:71
Interacting mature miRNAs:76
Transcripts:ENSRNOT00000016745, ENSRNOT00000073971
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 34 11 4 4 2 2 40 24 41 11 2
Low 3 9 46 37 19 37 6 9 34 11 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000073971   ⟹   ENSRNOP00000064046
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1679,725,643 - 79,793,619 (-)Ensembl
RefSeq Acc Id: XM_002728436   ⟹   XP_002728482
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21674,647,147 - 74,737,818 (-)NCBI
Rnor_6.01679,725,629 - 79,816,477 (-)NCBI
Rnor_5.01679,302,340 - 79,392,426 (-)NCBI
RGSC_v3.41679,458,304 - 79,547,225 (-)RGD
Sequence:
RefSeq Acc Id: XM_006222290   ⟹   XP_006222352
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera1672,465,044 - 72,554,359 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253400   ⟹   XP_006253462
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21674,648,316 - 74,738,784 (-)NCBI
Rnor_6.01679,725,629 - 79,817,065 (-)NCBI
Rnor_5.01679,302,340 - 79,392,426 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253401   ⟹   XP_006253463
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01679,725,629 - 79,811,002 (-)NCBI
Rnor_5.01679,302,340 - 79,392,426 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253402   ⟹   XP_006253464
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01679,725,629 - 79,816,477 (-)NCBI
Rnor_5.01679,302,340 - 79,392,426 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253403   ⟹   XP_006253465
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21674,648,316 - 74,737,818 (-)NCBI
Rnor_6.01679,725,629 - 79,816,477 (-)NCBI
Rnor_5.01679,302,340 - 79,392,426 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017587610   ⟹   XP_017443099
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera1672,465,044 - 72,553,771 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017587611   ⟹   XP_017443100
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera1672,465,044 - 72,548,298 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017587612   ⟹   XP_017443101
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera1672,465,044 - 72,553,771 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017587613   ⟹   XP_017443102
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera1672,465,044 - 72,553,771 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039095251   ⟹   XP_038951179
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21674,648,316 - 74,737,818 (-)NCBI
Protein Sequences
Protein RefSeqs XP_002728482 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253462 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253465 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951179 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM08936 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_002728482   ⟸   XM_002728436
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006222352   ⟸   XM_006222290
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006253462   ⟸   XM_006253400
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006253464   ⟸   XM_006253402
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006253465   ⟸   XM_006253403
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006253463   ⟸   XM_006253401
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017443101   ⟸   XM_017587612
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017443102   ⟸   XM_017587613
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017443099   ⟸   XM_017587610
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017443100   ⟸   XM_017587611
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000064046   ⟸   ENSRNOT00000073971
RefSeq Acc Id: XP_038951179   ⟸   XM_039095251
- Peptide Label: isoform X2
Protein Domains
DH

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565043 AgrOrtholog
Ensembl Genes ENSRNOG00000012561 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000064046 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000073971 UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro ARHGEF10 UniProtKB/TrEMBL
  ARHGEF10/ARHGEF17 UniProtKB/TrEMBL
  DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  PH/PTB_dom UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
NCBI Gene 306618 ENTREZGENE
PANTHER PTHR12877 UniProtKB/TrEMBL
  PTHR12877:SF14 UniProtKB/TrEMBL
Pfam RhoGEF UniProtKB/TrEMBL
PhenoGen Arhgef10 PhenoGen
PROSITE DH_2 UniProtKB/TrEMBL
SMART RhoGEF UniProtKB/TrEMBL
Superfamily-SCOP DH-domain UniProtKB/TrEMBL
  WD40_like UniProtKB/TrEMBL
UniProt M0R3X3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-19 Arhgef10  Rho guanine nucleotide exchange factor 10  Arhgef10  Rho guanine nucleotide exchange factor (GEF) 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-11-25 Arhgef10  Rho guanine nucleotide exchange factor (GEF) 10  RGD1565043  similar to Rho guanine nucleotide exchange factor (GEF) 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1565043  similar to Rho guanine nucleotide exchange factor (GEF) 10   RGD1565043_predicted  similar to Rho guanine nucleotide exchange factor (GEF) 10 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1565043_predicted  similar to Rho guanine nucleotide exchange factor (GEF) 10 (predicted)  LOC306618  similar to Rho guanine nucleotide exchange factor (GEF) 10  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC306618  similar to Rho guanine nucleotide exchange factor (GEF) 10      Symbol and Name status set to provisional 70820 PROVISIONAL