Nras (NRAS proto-oncogene, GTPase) - Rat Genome Database

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Gene: Nras (NRAS proto-oncogene, GTPase) Rattus norvegicus
Analyze
Symbol: Nras
Name: NRAS proto-oncogene, GTPase
RGD ID: 3205
Description: Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Involved in myoblast differentiation. Predicted to be located in Golgi apparatus and membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 6; autoimmune lymphoproliferative syndrome type 4; endocrine gland cancer (multiple); hematologic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human NRAS (NRAS proto-oncogene, GTPase); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; Fc epsilon receptor mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-di-tert-butyl-4-methylphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GTPase NRas; neuroblastoma ras oncogene; neuroblastoma RAS viral (v-ras) oncogene homolog; neuroblastoma RAS viral oncogene homolog; transforming protein N-Ras
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Nras-ps1  
Allele / Splice: Nras-ps1  
Candidate Gene For: Cia10
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22190,582,885 - 190,593,509 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2190,582,918 - 190,591,626 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2198,180,438 - 198,188,074 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02196,052,865 - 196,060,501 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02190,870,131 - 190,877,767 (+)NCBIRnor_WKY
Rnor_6.02205,553,119 - 205,563,716 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2205,553,163 - 205,560,791 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02224,983,707 - 224,994,303 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42198,292,650 - 198,300,286 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12198,255,369 - 198,265,062 (+)NCBI
Celera2183,056,304 - 183,063,940 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
acute promyelocytic leukemia  (ISO)
adrenocortical carcinoma  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
anemia  (ISO)
autoimmune lymphoproliferative syndrome  (ISO)
autoimmune lymphoproliferative syndrome type 4  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
B-cell lymphoma  (ISO)
Brain Neoplasms  (ISO)
cervical cancer  (ISO)
cholangitis  (ISO)
chronic lymphocytic leukemia  (ISO)
chronic myelogenous leukemia, BCR-ABL1 positive  (ISO)
chronic myeloid leukemia  (ISO)
chronic myelomonocytic leukemia  (ISO)
colon carcinoma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
disease of cellular proliferation  (ISO)
epidermal nevus  (ISO)
Experimental Arthritis  (IEP)
Experimental Leukemia  (IAGP)
Experimental Liver Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
Experimental Sarcoma  (IAGP)
Follicular Thyroid Cancer  (ISO)
gastric adenocarcinoma  (ISO)
glioblastoma  (ISO)
hepatocellular carcinoma  (ISO)
juvenile myelomonocytic leukemia  (ISO)
large congenital melanocytic nevus  (ISO)
leukemia  (ISO)
Leukocytosis  (ISO)
linear nevus sebaceous syndrome  (ISO)
liver carcinoma  (ISO)
Liver Metastasis  (ISO)
lung adenocarcinoma  (ISO)
lung non-small cell carcinoma  (ISO)
lymphoma  (ISO)
medulloblastoma  (ISO)
melanoma  (ISO)
Mouth Neoplasms  (IEP)
multiple myeloma  (ISO)
myelodysplastic syndrome  (ISO)
myeloid leukemia associated with Down Syndrome  (ISO)
myeloid neoplasm  (ISO)
Nasopharyngeal Neoplasms  (ISO)
neuroblastoma  (ISO)
Neurocutaneous Melanosis  (ISO)
Neurodevelopmental Disorders  (ISO)
neurofibrosarcoma  (ISO)
non-Hodgkin lymphoma  (ISO)
Noonan syndrome  (ISO)
Noonan syndrome 1  (ISO)
Noonan syndrome 6  (ISO)
ovarian serous cystadenocarcinoma  (ISO)
papillary renal cell carcinoma  (ISO)
Paraproteinemias  (ISO)
Pigmented Nevus  (ISO)
plasma cell neoplasm  (ISO)
prostate cancer  (ISO)
Prostate Cancer, Hereditary, 1  (ISO)
RASopathy  (ISO)
rectal benign neoplasm  (ISO)
renal cell carcinoma  (ISO)
Renal Cell Carcinoma 1  (ISO)
Sebaceous Nevus Syndrome and Hemimegalencephaly  (ISO)
skin melanoma  (ISO)
Splenomegaly  (ISO)
Stomach Neoplasms  (ISO)
Thyroid Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
uterine cancer  (ISO)
visual epilepsy  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-nitrotoluene  (EXP)
ammonium chloride  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP)
bromochloroacetic acid  (EXP)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carboplatin  (EXP)
chlorpyrifos  (EXP)
choline  (ISO)
cobimetinib  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
daunorubicin  (ISO)
deguelin  (ISO)
deoxycholic acid  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
disulfiram  (ISO)
ethanol  (ISO)
fenthion  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glyphosate  (ISO)
hydrogen cyanide  (ISO)
hydroquinone  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
metformin  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
microcystin-LR  (ISO)
N-Nitrosodi-n-butylamine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nickel atom  (ISO)
ouabain  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
pemetrexed  (ISO)
phenobarbital  (EXP)
phlorizin  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sorafenib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
trichloroethene  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vemurafenib  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Tumour mutation status and sites of metastasis in patients with cutaneous melanoma. Adler NR, etal., Br J Cancer. 2017 Sep 26;117(7):1026-1035. doi: 10.1038/bjc.2017.254. Epub 2017 Aug 8.
2. Activation of RAS family genes in urothelial carcinoma. Boulalas I, etal., J Urol. 2009 May;181(5):2312-9. Epub 2009 Mar 19.
3. Somatic integration of an oncogene-harboring Sleeping Beauty transposon models liver tumor development in the mouse. Carlson CM, etal., Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17059-64. doi: 10.1073/pnas.0502974102. Epub 2005 Nov 14.
4. Comparison of liver oncogenic potential among human RAS isoforms. Chung SI, etal., Oncotarget. 2016 Feb 9;7(6):7354-66. doi: 10.18632/oncotarget.6931.
5. Neuroblastoma RAS Viral Oncogene Homolog (NRAS) Is a Novel Prognostic Marker and Contributes to Sorafenib Resistance in Hepatocellular Carcinoma. Dietrich P, etal., Neoplasia. 2019 Mar;21(3):257-268. doi: 10.1016/j.neo.2018.11.011. Epub 2019 Jan 25.
6. Clonal architectures and driver mutations in metastatic melanomas. Ding L, etal., PLoS One. 2014 Nov 13;9(11):e111153. doi: 10.1371/journal.pone.0111153. eCollection 2014.
7. NRAS mutations in de novo acute leukemia: prevalence and clinical significance. Dunna NR, etal., Indian J Biochem Biophys. 2014 Jun;51(3):207-10.
8. Metastatic Pattern of Stage IV Colorectal Cancer with High-Frequency Microsatellite Instability as a Prognostic Factor. Fujiyoshi K, etal., Anticancer Res. 2017 Jan;37(1):239-247. doi: 10.21873/anticanres.11313.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Mapping autoimmunity genes. Griffiths MM, etal., Curr Opin Immunol. 1999 Dec;11(6):689-700.
12. Identification of a new non-major histocompatibility complex genetic locus on chromosome 2 that controls disease severity in collagen-induced arthritis in rats. Gulko PS, etal., Arthritis Rheum 1998 Dec;41(12):2122-31
13. The inv(3)(q21q26)/t(3;3)(q21;q26) is frequently accompanied by alterations of the RUNX1, KRAS and NRAS and NF1 genes and mediates adverse prognosis both in MDS and in AML: a study in 39 cases of MDS or AML. Haferlach C, etal., Leukemia. 2011 May;25(5):874-7. doi: 10.1038/leu.2011.5. Epub 2011 Feb 1.
14. AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/SKP2, and c-Myc pathways. Ho C, etal., Hepatology. 2012 Mar;55(3):833-45. doi: 10.1002/hep.24736. Epub 2011 Dec 19.
15. Expression of N-ras gene in human primary hepatocarcinoma. Hu LF, etal., Sci Sin B. 1986 Feb;29(2):181-6.
16. Detection of multiple gene amplifications in glioblastoma multiforme using array-based comparative genomic hybridization. Hui AB, etal., Lab Invest. 2001 May;81(5):717-23.
17. RAS oncogene suppression induces apoptosis followed by more differentiated and less myelosuppressive disease upon relapse of acute myeloid leukemia. Kim WI, etal., Blood. 2009 Jan 29;113(5):1086-96. doi: 10.1182/blood-2008-01-132316. Epub 2008 Oct 24.
18. Mutation analysis of the Ras pathway genes NRAS, HRAS, KRAS and BRAF in glioblastomas. Knobbe CB, etal., Acta Neuropathol. 2004 Dec;108(6):467-70. doi: 10.1007/s00401-004-0929-9. Epub 2004 Oct 28.
19. The ability of endogenous Nras oncogenes to initiate leukemia is codon-dependent. Kong G, etal., Leukemia. 2016 Sep;30(9):1935-8. doi: 10.1038/leu.2016.89. Epub 2016 Apr 25.
20. Cia5d regulates a new fibroblast-like synoviocyte invasion-associated gene expression signature. Laragione T, etal., Arthritis Res Ther. 2008 Aug 15;10(4):R92.
21. Differential expression of protooncogenes related to transformation and cancer progression in rat myoblasts. Leibovitch SA, etal., Cancer Res. 1986 Aug;46(8):4097-103.
22. Transcriptional activation of H- and N-ras oncogenes in human cervical cancer. Mammas IN, etal., Gynecol Oncol. 2004 Mar;92(3):941-8.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Mutation of NRAS but not KRAS significantly reduces myeloma sensitivity to single-agent bortezomib therapy. Mulligan G, etal., Blood. 2014 Jan 30;123(5):632-9. doi: 10.1182/blood-2013-05-504340. Epub 2013 Dec 11.
25. NRAS mutations with low allele burden have independent prognostic significance for patients with lower risk myelodysplastic syndromes. Murphy DM, etal., Leukemia. 2013 Oct;27(10):2077-81. doi: 10.1038/leu.2013.160. Epub 2013 May 27.
26. CD4+ T cells from patients with primary biliary cholangitis show T cell activation and differentially expressed T-cell receptor repertoires. Nakagawa R, etal., Hepatol Res. 2019 Jun;49(6):653-662. doi: 10.1111/hepr.13318. Epub 2019 Feb 26.
27. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
28. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
29. Loss of heterozygosity at the N-ras locus in 7,12-dimethylbenz anthracene-induced rat leukemia. Osaka M, etal., Mol Carcinog. 1997 Apr;18(4):206-12.
30. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
31. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
32. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
33. GOA pipeline RGD automated data pipeline
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Comprehensive gene review and curation RGD comprehensive gene curation
37. MEK1/2 dual-specificity protein kinases: Structure and regulation. Roskoski R Jr Biochem Biophys Res Commun. 2012 Jan 6;417(1):5-10. Epub 2011 Dec 8.
38. An increase in N-Ras expression is associated with development of hormone refractory prostate cancer in a subset of patients. Traynor P, etal., Dis Markers. 2008;24(3):157-65.
39. Diabetes increases both N-ras and ets-1 expression during rat oral oncogenesis resulting in enhanced cell proliferation and metastatic potential. Vairaktaris E, etal., In Vivo. 2007 Jul-Aug;21(4):615-21.
40. The rat N-ras gene; interference of pseudogenes with the detection of activating point mutations. van Kranen HJ, etal., Carcinogenesis 1994 Feb;15(2):307-11.
41. Ras gene mutations in 7,12-dimethylbenzanthracene (DMBA)-induced rat sarcomas. Walentinsson A and Levan G, Cancer Lett. 2001 May 10;166(1):47-53.
42. Endogenous oncogenic Nras mutation initiates hematopoietic malignancies in a dose- and cell type-dependent manner. Wang J, etal., Blood. 2011 Jul 14;118(2):368-79. doi: 10.1182/blood-2010-12-326058. Epub 2011 May 17.
43. Localization in rats of genetic loci regulating susceptibility to experimental erosive arthritis and related autoimmune diseases. Wilder RL, etal., Transplant Proc 1999 May;31(3):1585-8
44. Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector. Willard FS, etal., PLoS One. 2009;4(3):e4884. doi: 10.1371/journal.pone.0004884. Epub 2009 Mar 25.
45. Deficiency of beta Common Receptor Moderately Attenuates the Progression of Myeloproliferative Neoplasm in NrasG12D/+ Mice. Zhang J, etal., J Biol Chem. 2015 Jul 31;290(31):19093-103. doi: 10.1074/jbc.M115.653154. Epub 2015 Jun 16.
Additional References at PubMed
PMID:1714740   PMID:2105496   PMID:7905676   PMID:8316835   PMID:8344525   PMID:10085069   PMID:12477932   PMID:13901431   PMID:15489334   PMID:15983034   PMID:17380122   PMID:18006851  
PMID:18314492   PMID:19946888   PMID:20458337   PMID:20534588   PMID:20603646   PMID:21444916   PMID:21968647   PMID:23209302   PMID:23376485   PMID:23619365   PMID:23871832   PMID:24553818  
PMID:30712867  


Genomics

Comparative Map Data
Nras
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22190,582,885 - 190,593,509 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2190,582,918 - 190,591,626 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2198,180,438 - 198,188,074 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02196,052,865 - 196,060,501 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02190,870,131 - 190,877,767 (+)NCBIRnor_WKY
Rnor_6.02205,553,119 - 205,563,716 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2205,553,163 - 205,560,791 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02224,983,707 - 224,994,303 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42198,292,650 - 198,300,286 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12198,255,369 - 198,265,062 (+)NCBI
Celera2183,056,304 - 183,063,940 (+)NCBICelera
Cytogenetic Map2q34NCBI
NRAS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381114,704,469 - 114,716,771 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1114,704,469 - 114,716,771 (-)EnsemblGRCh38hg38GRCh38
GRCh371115,247,090 - 115,259,392 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361115,051,108 - 115,061,038 (-)NCBINCBI36Build 36hg18NCBI36
Build 341114,961,626 - 114,971,557NCBI
Celera1113,476,335 - 113,488,757 (-)NCBICelera
Cytogenetic Map1p13.2NCBI
HuRef1113,105,559 - 113,117,974 (-)NCBIHuRef
CHM1_11115,361,892 - 115,374,317 (-)NCBICHM1_1
T2T-CHM13v2.01114,715,929 - 114,728,216 (-)NCBIT2T-CHM13v2.0
Nras
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393102,965,601 - 102,975,230 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3102,965,601 - 102,975,230 (+)EnsemblGRCm39 Ensembl
GRCm383103,058,285 - 103,067,914 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3103,058,285 - 103,067,914 (+)EnsemblGRCm38mm10GRCm38
MGSCv373102,862,208 - 102,871,837 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363103,187,290 - 103,197,396 (+)NCBIMGSCv36mm8
Celera3105,263,160 - 105,272,744 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map345.25NCBI
Nras
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543518,001,517 - 18,009,103 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543518,001,517 - 18,009,105 (-)NCBIChiLan1.0ChiLan1.0
NRAS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11122,890,505 - 122,903,585 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1122,890,505 - 122,903,585 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0187,837,146 - 87,850,013 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
NRAS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11752,411,733 - 52,418,788 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1752,411,733 - 52,418,788 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1752,062,320 - 52,069,399 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01753,289,080 - 53,296,149 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1753,286,139 - 53,296,201 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11752,323,232 - 52,330,285 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01752,365,409 - 52,372,486 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01752,938,741 - 52,945,813 (-)NCBIUU_Cfam_GSD_1.0
Nras
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505814,406,378 - 14,416,046 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493662773,413 - 82,590 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493662773,413 - 82,590 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NRAS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4105,845,872 - 105,858,227 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14105,845,913 - 105,853,769 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24116,034,666 - 116,042,522 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NRAS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12018,953,273 - 18,966,002 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2018,953,883 - 18,961,931 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603821,707,389 - 21,720,123 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nras
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477210,358,554 - 10,369,371 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nras
27 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:459
Count of miRNA genes:217
Interacting mature miRNAs:266
Transcripts:ENSRNOT00000039572
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2184114274202447032Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
7488929Bp366Blood pressure QTL 3660.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2184974550193094998Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2185876309219753474Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2189599258218414891Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat

Markers in Region
AA960392  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22190,582,442 - 190,582,731 (+)MAPPERmRatBN7.2
Rnor_6.02205,552,650 - 205,552,938NCBIRnor6.0
Rnor_5.02224,983,237 - 224,983,525UniSTSRnor5.0
RGSC_v3.42198,292,137 - 198,292,425UniSTSRGSC3.4
Celera2183,055,791 - 183,056,079UniSTS
Cytogenetic Map2q34UniSTS
PMC316567P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22190,584,991 - 190,585,176 (+)MAPPERmRatBN7.2
Rnor_6.02205,555,199 - 205,555,383NCBIRnor6.0
Rnor_5.02224,985,786 - 224,985,970UniSTSRnor5.0
RGSC_v3.42198,294,686 - 198,294,870UniSTSRGSC3.4
Celera2183,058,340 - 183,058,524UniSTS
Cytogenetic Map2q34UniSTS
PMC86690P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22190,584,992 - 190,585,137 (+)MAPPERmRatBN7.2
Rnor_6.02205,555,200 - 205,555,344NCBIRnor6.0
Rnor_5.02224,985,787 - 224,985,931UniSTSRnor5.0
RGSC_v3.42198,294,687 - 198,294,831UniSTSRGSC3.4
Celera2183,058,341 - 183,058,485UniSTS
Cytogenetic Map2q34UniSTS
PMC86690P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22190,584,992 - 190,585,176 (+)MAPPERmRatBN7.2
Rnor_6.02205,555,200 - 205,555,383NCBIRnor6.0
Rnor_5.02224,985,787 - 224,985,970UniSTSRnor5.0
RGSC_v3.42198,294,687 - 198,294,870UniSTSRGSC3.4
Celera2183,058,341 - 183,058,524UniSTS
Cytogenetic Map2q34UniSTS
PMC28413P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22190,583,526 - 190,583,641 (+)MAPPERmRatBN7.2
mRatBN7.2X116,761,789 - 116,761,904 (+)MAPPERmRatBN7.2
Rnor_6.02205,553,734 - 205,553,848NCBIRnor6.0
Rnor_6.0X124,119,165 - 124,119,279NCBIRnor6.0
Rnor_5.02224,984,321 - 224,984,435UniSTSRnor5.0
Rnor_5.0X124,205,407 - 124,205,521UniSTSRnor5.0
Cytogenetic Map2q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 56 40 19 40 6 7 74 35 41 11 6
Low 1 1 1 1 2 4 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000039572   ⟹   ENSRNOP00000036381
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2190,583,518 - 190,591,112 (+)Ensembl
Rnor_6.0 Ensembl2205,553,163 - 205,560,791 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098182   ⟹   ENSRNOP00000078755
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2190,582,918 - 190,591,626 (+)Ensembl
RefSeq Acc Id: NM_080766   ⟹   NP_542944
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22190,582,956 - 190,590,592 (+)NCBI
Rnor_6.02205,553,163 - 205,560,799 (+)NCBI
Rnor_5.02224,983,707 - 224,994,303 (+)NCBI
RGSC_v3.42198,292,650 - 198,300,286 (+)RGD
Celera2183,056,304 - 183,063,940 (+)RGD
Sequence:
RefSeq Acc Id: XM_006233059   ⟹   XP_006233121
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22190,582,885 - 190,593,509 (+)NCBI
Rnor_6.02205,553,119 - 205,563,716 (+)NCBI
Rnor_5.02224,983,707 - 224,994,303 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_542944   ⟸   NM_080766
- UniProtKB: Q4KMB1 (UniProtKB/Swiss-Prot),   Q04970 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006233121   ⟸   XM_006233059
- Peptide Label: isoform X1
- UniProtKB: Q4KMB1 (UniProtKB/Swiss-Prot),   Q04970 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000036381   ⟸   ENSRNOT00000039572
RefSeq Acc Id: ENSRNOP00000078755   ⟸   ENSRNOT00000098182

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q04970-F1-model_v2 AlphaFold Q04970 1-189 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691625
Promoter ID:EPDNEW_R2150
Type:multiple initiation site
Name:Nras_1
Description:NRAS proto-oncogene, GTPase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02205,553,146 - 205,553,206EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3205 AgrOrtholog
BioCyc Gene G2FUF-51824 BioCyc
Ensembl Genes ENSRNOG00000023079 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000036381.4 UniProtKB/TrEMBL
  ENSRNOP00000078755 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000039572.4 UniProtKB/TrEMBL
  ENSRNOT00000098182 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7368145 IMAGE-MGC_LOAD
InterPro P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase_Ras-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24605 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112605 IMAGE-MGC_LOAD
NCBI Gene 24605 ENTREZGENE
PANTHER PTHR24070 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ras UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB NRAS RGD
PhenoGen Nras PhenoGen
PROSITE RAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RHO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs small_GTP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2QIP9_RAT UniProtKB/TrEMBL
  Q04970 ENTREZGENE
  Q4KMB1 ENTREZGENE
  RASN_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q4KMB1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-29 Nras  NRAS proto-oncogene, GTPase  Nras  neuroblastoma RAS viral oncogene homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-04-14 Nras  neuroblastoma RAS viral oncogene homolog  Nras  neuroblastoma RAS viral (v-ras) oncogene homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-17 Nras  neuroblastoma RAS viral (v-ras) oncogene homolog  Nras  neuroblastoma ras oncogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Nras  neuroblastoma ras oncogene      Name updated 1299863 APPROVED
2002-11-06 Nras  neuroblastoma RAS viral (v-ras) oncogene homolog    Neuroblastoma RAS viral (v-ras) oncogene homolog  Name updated 625702 APPROVED
2002-06-10 Nras  Neuroblastoma RAS viral (v-ras) oncogene homolog      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease involved in the severity of collagen-induced arthritis 61063