Agxt (alanine--glyoxylate aminotransferase) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Agxt (alanine--glyoxylate aminotransferase) Rattus norvegicus
Analyze
Symbol: Agxt
Name: alanine--glyoxylate aminotransferase
RGD ID: 2073
Description: Enables L-serine-pyruvate transaminase activity; alanine-glyoxylate transaminase activity; and amino acid binding activity. Involved in carboxylic acid biosynthetic process; response to cAMP; and response to glucocorticoid. Located in mitochondrial matrix and peroxisome. Human ortholog(s) of this gene implicated in primary hyperoxaluria type 1. Orthologous to human AGXT (alanine--glyoxylate aminotransferase); PARTICIPATES IN alanine metabolic pathway; dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AGT; alanine--glyoxylate and serine--pyruvate aminotransferase; alanine-glyoxylate aminotransferase; alanine-glyoxylate aminotransferase (serine-pyruvate aminotransferase); angiotensin receptor 2; serine--pyruvate aminotransferase; serine--pyruvate aminotransferase, mitochondrial; serine--pyruvate aminotransferase, peroxisomal; serine-pyruvate aminotransferase; serine:pyruvate aminotransferase SPT; serine:pyruvate aminotransferase, SPT,; serine:pyruvate/alanine:glyoxylate aminotransferase; Spat; SPT
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Agxt_v1 ; Agxt_v2
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89101,122,793 - 101,132,746 (+)NCBIGRCr8
mRatBN7.2993,675,384 - 93,685,337 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl993,675,384 - 93,685,336 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9102,110,940 - 102,120,893 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09107,246,884 - 107,256,803 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09105,603,034 - 105,612,953 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09100,281,339 - 100,291,292 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9100,281,339 - 100,291,291 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0999,939,444 - 99,949,397 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4992,412,128 - 92,422,075 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1992,616,896 - 92,626,844 (+)NCBI
Celera991,210,785 - 91,220,737 (+)NCBICelera
Cytogenetic Map9q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
Allylamine  (EXP)
ammonium chloride  (EXP)
Benoxacor  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
carbaryl  (EXP)
CGP 52608  (ISO)
choline  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
diazinon  (ISO)
disulfiram  (ISO)
doxorubicin  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
Heliotrine  (ISO)
inulin  (ISO)
mercaptopurine  (EXP)
mercury dichloride  (ISO)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
nimesulide  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
ozone  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (ISO)
purine-6-thiol  (EXP)
quercetin  (ISO)
rotenone  (EXP)
senecionine  (ISO)
Senkirkine  (ISO)
sodium arsenite  (EXP,ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topiramate  (EXP)
trichloroethene  (ISO)
triphenyl phosphate  (EXP)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
mitochondrial matrix  (IDA,IEA)
mitochondrion  (IEA,TAS)
peroxisomal matrix  (ISO)
peroxisome  (IBA,IDA,IEA,ISO,TAS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Enzymological and mutational analysis of a complex primary hyperoxaluria type 1 phenotype involving alanine:glyoxylate aminotransferase peroxisome-to-mitochondrion mistargeting and intraperoxisomal aggregation. Danpure CJ, etal., Am J Hum Genet 1993 Aug;53(2):417-32.
2. Evolution of alanine:glyoxylate aminotransferase 1 peroxisomal and mitochondrial targeting. A survey of its subcellular distribution in the livers of various representatives of the classes Mammalia, Aves and Amphibia. Danpure CJ, etal., Eur J Cell Biol. 1994 Aug;64(2):295-313.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Inhibitory effect of cortisone acetate on the stimulation of rat liver cytosol L-serrine. Pyruvate aminotransferase by dibutyryl adenosine 3,5-monophosphate. Hoshino J, etal., Biochim Biophys Acta. 1975 Jul 14;399(1):42-9.
6. Regulation and characterization of L-serine: pyruvate aminotransferase in rat liver cytosol and mitochondria. Hoshino J, etal., Z Naturforsch C. 1977 Mar-Apr;32(3-4):249-53.
7. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
8. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, etal., J Biol Chem. 2004 Jan 2;279(1):421-8. Epub 2003 Oct 15.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Capillary electrophoresis assay of alanine:glyoxylate aminotransferase activity in rat liver. Nishijima S, etal., J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Nov 15;780(1):13-9.
12. Hepatic alanine-glyoxylate aminotransferase activity and oxalate metabolism in vitamin B6 deficient rats. Nishijima S, etal., J Urol. 2003 Feb;169(2):683-6.
13. Primary hyperoxaluria type I due to a point mutation of T to C in the coding region of the serine:pyruvate aminotransferase gene. Nishiyama K, etal., Biochem Biophys Res Commun 1991 May 15;176(3):1093-9.
14. Nucleotide sequence of the cDNA encoding the precursor for mitochondrial serine:pyruvate aminotransferase of rat liver. Oda T, etal., Eur J Biochem 1987 Nov 2;168(3):537-42.
15. Cloning and expression in Escherichia coli of cDNA for serine: pyruvate aminotransferase of rat liver. Oda T, etal., Eur J Biochem. 1985 Aug 1;150(3):415-21.
16. Mitochondrial targeting signal-induced conformational change and repression of the peroxisomal targeting signal of the precursor for rat liver serine:pyruvate/alanine:glyoxylate aminotransferase. Oda T, etal., J Biochem (Tokyo). 2000 Apr;127(4):665-71.
17. Generation from a single gene of two mRNAs that encode the mitochondrial and peroxisomal serine:pyruvate aminotransferase of rat liver. Oda T, etal., J Biol Chem 1990 May 5;265(13):7513-9.
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Quantitative cryoimmunogold electron microscopic studies on induction of serine: pyruvate aminotransferase in rat liver mitochondria by administration of glucagon. Satoh S, etal., Cell Struct Funct. 1995 Feb;20(1):89-96.
24. The role of Sp1 and AP-2 in basal and protein kinase A--induced expression of mitochondrial serine:pyruvate aminotransferase in hepatocytes. Uchida C, etal., J Biol Chem 2002 Oct 18;277(42):39082-92.
25. Immunocytochemical demonstration of serine: pyruvate amino-transferase in peroxisomes and mitochondria of rat kidney. Yokota S and Oda T, Histochemistry. 1985;83(1):81-5.
Additional References at PubMed
PMID:1703535   PMID:2691502   PMID:3418107   PMID:3709805   PMID:8406472   PMID:8889548   PMID:9053548   PMID:12477932   PMID:12899834   PMID:15802217   PMID:16971151   PMID:17110443  
PMID:17696873   PMID:18492492   PMID:20133649   PMID:20178365   PMID:22198249   PMID:22529745   PMID:25446530  


Genomics

Comparative Map Data
Agxt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89101,122,793 - 101,132,746 (+)NCBIGRCr8
mRatBN7.2993,675,384 - 93,685,337 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl993,675,384 - 93,685,336 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9102,110,940 - 102,120,893 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09107,246,884 - 107,256,803 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09105,603,034 - 105,612,953 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09100,281,339 - 100,291,292 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9100,281,339 - 100,291,291 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0999,939,444 - 99,949,397 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4992,412,128 - 92,422,075 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1992,616,896 - 92,626,844 (+)NCBI
Celera991,210,785 - 91,220,737 (+)NCBICelera
Cytogenetic Map9q36NCBI
AGXT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382240,868,824 - 240,880,500 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2240,868,824 - 240,880,502 (+)EnsemblGRCh38hg38GRCh38
GRCh372241,808,241 - 241,819,917 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362241,456,835 - 241,467,210 (+)NCBINCBI36Build 36hg18NCBI36
Build 342241,528,151 - 241,538,527NCBI
Celera2235,480,100 - 235,491,174 (+)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2233,568,172 - 233,579,109 (+)NCBIHuRef
CHM1_12241,814,212 - 241,824,586 (+)NCBICHM1_1
T2T-CHM13v2.02241,367,223 - 241,379,660 (+)NCBIT2T-CHM13v2.0
Agxt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,062,962 - 93,073,143 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl193,062,962 - 93,073,143 (+)EnsemblGRCm39 Ensembl
GRCm38193,135,240 - 93,145,421 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl193,135,240 - 93,145,421 (+)EnsemblGRCm38mm10GRCm38
MGSCv37195,031,853 - 95,041,998 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36194,965,651 - 94,988,099 (+)NCBIMGSCv36mm8
Celera196,079,940 - 96,090,082 (+)NCBICelera
Cytogenetic Map1DNCBI
cM Map147.0NCBI
Agxt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955542710,005 - 717,741 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955542710,506 - 720,564 (-)NCBIChiLan1.0ChiLan1.0
AGXT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213143,555,885 - 143,567,244 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B143,570,805 - 143,582,039 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B128,125,289 - 128,137,091 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B246,928,784 - 246,939,837 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B246,928,784 - 246,939,837 (+)Ensemblpanpan1.1panPan2
AGXT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12550,968,291 - 50,976,089 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2551,181,404 - 51,189,176 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02551,163,250 - 51,171,015 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2551,163,418 - 51,170,784 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12551,004,270 - 51,012,034 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02550,750,660 - 50,758,423 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02551,026,487 - 51,034,252 (+)NCBIUU_Cfam_GSD_1.0
Agxt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303192,351,908 - 192,362,526 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936745857,102 - 867,477 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936745856,915 - 867,477 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGXT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15139,720,612 - 139,730,736 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115139,720,648 - 139,730,737 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215157,616,991 - 157,627,404 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AGXT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110126,933,711 - 126,943,980 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10126,933,835 - 126,944,354 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604072,444,112 - 72,454,149 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Agxt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248475,067,201 - 5,077,525 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248475,066,356 - 5,073,538 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Agxt
76 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:166
Count of miRNA genes:131
Interacting mature miRNAs:135
Transcripts:ENSRNOT00000029127
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)992491589100929786Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)977813894101597663Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat

Markers in Region
RH130348  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr89101,131,940 - 101,132,519 (+)Marker Load Pipeline
mRatBN7.2993,684,531 - 93,685,110 (+)MAPPERmRatBN7.2
Rnor_6.09100,290,487 - 100,291,065NCBIRnor6.0
Rnor_5.0999,948,592 - 99,949,170UniSTSRnor5.0
RGSC_v3.4992,421,275 - 92,421,853UniSTSRGSC3.4
Celera991,219,932 - 91,220,510UniSTS
Cytogenetic Map9q34-q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 4 5 36 81 84 59 18 59 2 119 34 25 13 30 25

Sequence


Ensembl Acc Id: ENSRNOT00000029127   ⟹   ENSRNOP00000030340
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl993,675,384 - 93,685,336 (+)Ensembl
Rnor_6.0 Ensembl9100,281,339 - 100,291,291 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079305   ⟹   ENSRNOP00000070626
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl993,679,849 - 93,685,336 (+)Ensembl
Rnor_6.0 Ensembl9100,285,804 - 100,291,291 (+)Ensembl
RefSeq Acc Id: NM_001270659   ⟹   NP_001257588
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,127,258 - 101,132,746 (+)NCBI
mRatBN7.2993,679,849 - 93,685,337 (+)NCBI
Rnor_6.09100,285,804 - 100,291,292 (+)NCBI
Rnor_5.0999,939,444 - 99,949,397 (+)NCBI
Celera991,215,250 - 91,220,737 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001276706   ⟹   NP_001263635
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,122,793 - 101,132,746 (+)NCBI
mRatBN7.2993,675,384 - 93,685,337 (+)NCBI
Rnor_6.09100,281,339 - 100,291,292 (+)NCBI
Rnor_5.0999,939,444 - 99,949,397 (+)NCBI
Celera991,210,785 - 91,220,737 (+)NCBI
Sequence:
RefSeq Acc Id: NM_030656   ⟹   NP_085914
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,122,793 - 101,132,746 (+)NCBI
mRatBN7.2993,675,384 - 93,685,337 (+)NCBI
Rnor_6.09100,281,339 - 100,291,292 (+)NCBI
Rnor_5.0999,939,444 - 99,949,397 (+)NCBI
RGSC_v3.4992,412,128 - 92,422,075 (+)RGD
Celera991,210,785 - 91,220,737 (+)NCBI
Sequence:
RefSeq Acc Id: NP_085914   ⟸   NM_030656
- Peptide Label: isoform 1 precursor
- UniProtKB: Q9R2C7 (UniProtKB/Swiss-Prot),   P09139 (UniProtKB/Swiss-Prot),   Q5I0N5 (UniProtKB/TrEMBL),   A6JQX5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001263635   ⟸   NM_001276706
- Peptide Label: isoform 3
- UniProtKB: Q5I0N5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257588   ⟸   NM_001270659
- Peptide Label: isoform 2
- UniProtKB: A0A0G2JYE8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070626   ⟸   ENSRNOT00000079305
Ensembl Acc Id: ENSRNOP00000030340   ⟸   ENSRNOT00000029127
Protein Domains
Aminotransferase class V

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P09139-F1-model_v2 AlphaFold P09139 1-414 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2073 AgrOrtholog
BioCyc Gene G2FUF-26657 BioCyc
BioCyc Pathway GLYSYN-ALA-PWY [glycine biosynthesis III] BioCyc
BioCyc Pathway Image GLYSYN-ALA-PWY BioCyc
Ensembl Genes ENSRNOG00000023856 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000029127 ENTREZGENE
  ENSRNOT00000029127.4 UniProtKB/Swiss-Prot
  ENSRNOT00000079305 ENTREZGENE
Gene3D-CATH 3.40.640.10 UniProtKB/Swiss-Prot
  3.90.1150.10 UniProtKB/Swiss-Prot
InterPro Aminotrans_V_dom UniProtKB/Swiss-Prot
  Aminotrans_V_PyrdxlP_BS UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase_dom1 UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase_major UniProtKB/Swiss-Prot
  SP_NH2Trfase/AEP_transaminase UniProtKB/Swiss-Prot
KEGG Report rno:24792 UniProtKB/Swiss-Prot
NCBI Gene 24792 ENTREZGENE
PANTHER ALANINE--GLYOXYLATE AMINOTRANSFERASE UniProtKB/Swiss-Prot
  AMINOTRANSFERASE CLASS V UniProtKB/Swiss-Prot
Pfam Aminotran_5 UniProtKB/Swiss-Prot
PhenoGen Agxt PhenoGen
PIRSF SPT UniProtKB/Swiss-Prot
PROSITE AA_TRANSFER_CLASS_5 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000023856 RatGTEx
Superfamily-SCOP SSF53383 UniProtKB/Swiss-Prot
UniProt A0A0G2JYE8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8A1U8X5_RAT UniProtKB/TrEMBL
  A6JQX5 ENTREZGENE, UniProtKB/TrEMBL
  A6JQX6_RAT UniProtKB/TrEMBL
  A6JQX7_RAT UniProtKB/TrEMBL
  P09139 ENTREZGENE
  Q5I0N5 ENTREZGENE, UniProtKB/TrEMBL
  Q9R2C7 ENTREZGENE
  SPYA_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q9R2C7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-09-01 Agxt  alanine--glyoxylate aminotransferase  Agxt  alanine--glyoxylate and serine--pyruvate aminotransferase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2018-03-22 Agxt  alanine--glyoxylate and serine--pyruvate aminotransferase  Agxt  alanine-glyoxylate aminotransferase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Agxt  alanine-glyoxylate aminotransferase      Symbol and Name updated 629477 APPROVED
2003-03-07 Agxt  alanine-glyoxylate aminotransferase  Spat  Serine-pyruvate aminotransferase  Data merged from RGD:3743 628472 PROVISIONAL
2002-11-06 Agxt  angiotensin receptor 2    Alanine-glyoxylate aminotransferase (Serine-pyruvate aminotransferase)  Name updated 625702 APPROVED
2002-06-10 Agxt  Alanine-glyoxylate aminotransferase (Serine-pyruvate aminotransferase)      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Spat  Serine-pyruvate aminotransferase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization products of alternative initiation sites are localized to mitochondria and peroxisomes 632169
gene_expression expressed in liver 632168
gene_transcript variant transcripts are transcribed from different initiation sites in exon 1 and differ at the 5-terminal sequence 632169
gene_transcript variant transcript encoding polypeptide targeted to the mitochondria has 70 additional nucleotides which encode the N-terminal mitochondrial targeting sequence 632169