Gene: Agxt (alanine--glyoxylate and serine--pyruvate aminotransferase) Rattus norvegicus
Symbol: Agxt
Name: alanine--glyoxylate and serine--pyruvate aminotransferase
Description: ENCODES a protein that exhibits alanine-glyoxylate transaminase activity; amino acid binding; serine-pyruvate transaminase activity; INVOLVED IN glycine biosynthetic process, by transamination of glyoxylate; pyruvate biosynthetic process; response to cAMP; PARTICIPATES IN alanine metabolic pathway; dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; ASSOCIATED WITH Hyperoxaluria (ortholog); primary hyperoxaluria (ortholog); Primary Hyperoxaluria Type 1 (ortholog); FOUND IN mitochondrial matrix; mitochondrion; peroxisome; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,7-dihydropurine-6-thione; 3H-1,2-dithiole-3-thione
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AGT; alanine--glyoxylate aminotransferase; alanine-glyoxylate aminotransferase; alanine-glyoxylate aminotransferase (serine-pyruvate aminotransferase); angiotensin receptor 2; serine--pyruvate aminotransferase; serine--pyruvate aminotransferase, mitochondrial; serine--pyruvate aminotransferase, peroxisomal; serine-pyruvate aminotransferase; serine:pyruvate aminotransferase SPT; serine:pyruvate aminotransferase, SPT,; serine:pyruvate/alanine:glyoxylate aminotransferase; Spat; SPT
Allele / Splice: Agxt_v1   Agxt_v2  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.09100,281,339 - 100,291,292 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0999,939,444 - 99,949,397 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4992,412,128 - 92,422,075 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1992,616,896 - 92,626,844 (+)NCBI
Celera991,210,785 - 91,220,737 (+)NCBICelera
Cytogenetic Map9q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Agxt
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2073
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2018-05-29
Status: ACTIVE