Fabp2 (fatty acid binding protein 2) - Rat Genome Database

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Gene: Fabp2 (fatty acid binding protein 2) Rattus norvegicus
Analyze
Symbol: Fabp2
Name: fatty acid binding protein 2
RGD ID: 2591
Description: Enables long-chain fatty acid binding activity and long-chain fatty acid transmembrane transporter activity. Involved in fatty acid metabolic process; intestinal absorption; and long-chain fatty acid transport. Located in apical cortex and microvillus. Human ortholog(s) of this gene implicated in alcoholic liver cirrhosis; carotid stenosis; coronary artery disease; end stage renal disease; and obesity. Orthologous to human FABP2 (fatty acid binding protein 2); PARTICIPATES IN eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: FABP; FABPI; fatty acid binding protein 1; fatty acid binding protein 2, intestinal; fatty acid-binding protein 2; fatty acid-binding protein, intestinal; I-FABP; intestinal fatty acid binding protein; intestinal-type fatty acid-binding protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Is Marker For: QTLs:   Gluco14  
Candidate Gene For: Gluco14 Eau5
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82213,724,629 - 213,728,686 (+)NCBIGRCr8
mRatBN7.22211,040,032 - 211,044,089 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2211,040,032 - 211,044,089 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2218,717,756 - 218,721,725 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02216,625,543 - 216,629,512 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02211,471,755 - 211,475,828 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02227,080,912 - 227,083,654 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2227,080,924 - 227,083,501 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02246,442,292 - 246,445,034 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42219,591,502 - 219,605,097 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12219,554,563 - 219,568,159 (+)NCBI
Celera2203,465,826 - 203,473,400 (+)NCBICelera
RH 3.4 Map21537.1RGD
Cytogenetic Map2q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP,ISO)
2-palmitoylglycerol  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
aflatoxin M1  (ISO)
ammonium chloride  (EXP)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
corn oil  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
dichlorine  (EXP)
diclofenac  (EXP,ISO)
difenoconazole  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP)
fenofibrate  (ISO)
ferroheme b  (EXP)
folpet  (ISO)
furan  (EXP)
heme b  (EXP)
inulin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
metformin  (EXP)
microcystin-LR  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nordihydroguaiaretic acid  (EXP)
oleic acid  (EXP)
ozone  (EXP)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propamocarb  (ISO)
propiconazole  (ISO)
rifaximin  (ISO)
rotenone  (EXP)
sodium dichromate  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
troglitazone  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
apical cortex  (IDA)
cytoplasm  (IEA)
cytosol  (IBA)
microvillus  (IDA)
nucleus  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Intestinal FABP2 A54T polymorphism: association with insulin resistance and obesity in women. Albala C, etal., Obes Res. 2004 Feb;12(2):340-5.
2. Intestinal fatty acid binding protein may favor differential apical fatty acid binding in the intestine. Alpers DH, etal., Biochim Biophys Acta. 2000 Jan 31;1483(3):352-62.
3. Cloning of a cDNA encoding rat intestinal fatty acid binding protein. Alpers DH, etal., Proc Natl Acad Sci U S A 1984 Jan;81(2):313-7.
4. An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance. Baier LJ, etal., J Clin Invest 1995 Mar;95(3):1281-7.
5. Simulations of apo and holo-fatty acid binding protein: structure and dynamics of protein, ligand and internal water. Bakowies D and van Gunsteren WF, J Mol Biol 2002 Jan 25;315(4):713-36.
6. The fatty acid-binding protein-2 A54T polymorphism is associated with renal disease in patients with type 2 diabetes. Canani LH, etal., Diabetes. 2005 Nov;54(11):3326-30.
7. The T 54 allele of the intestinal fatty acid-binding protein 2 is associated with a parental history of stroke. Carlsson M, etal., J Clin Endocrinol Metab 2000 Aug;85(8):2801-4.
8. The alpha-helical domain of liver fatty acid binding protein is responsible for the diffusion-mediated transfer of fatty acids to phospholipid membranes. Corsico B, etal., Biochemistry. 2004 Mar 30;43(12):3600-7.
9. Fatty acid transfer from intestinal fatty acid binding protein to membranes: electrostatic and hydrophobic interactions. Corsico B, etal., J Lipid Res. 2005 Aug;46(8):1765-72. Epub 2005 May 1.
10. Swapping core residues in homologous proteins swaps folding mechanism. Dalessio PM, etal., Biochemistry. 2005 Mar 1;44(8):3082-90.
11. Protein-membrane interaction and fatty acid transfer from intestinal fatty acid-binding protein to membranes. Support for a multistep process. Falomir-Lockhart LJ, etal., J Biol Chem. 2006 May 19;281(20):13979-89. Epub 2006 Mar 21.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Codon-54 polymorphism of the fatty acid-binding protein 2 gene is associated with elevation of fasting and postprandial triglyceride in type 2 diabetes. Georgopoulos A, etal., J Clin Endocrinol Metab 2000 Sep;85(9):3155-60.
14. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
15. Analyzing the structures, functions and evolution of two abundant gastrointestinal fatty acid binding proteins with recombinant DNA and computational techniques. Gordon JI and Lowe JB, Chem Phys Lipids 1985 Aug 30;38(1-2):137-58.
16. Discrete backbone disorder in the nuclear magnetic resonance structure of apo intestinal fatty acid-binding protein: implications for the mechanism of ligand entry. Hodsdon ME and Cistola DP, Biochemistry. 1997 Feb 11;36(6):1450-60.
17. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
18. Comparison of the acute response to meals enriched with cis- or trans-fatty acids on glucose and lipids in overweight individuals with differing FABP2 genotypes. Lefevre M, etal., Metabolism. 2005 Dec;54(12):1652-8.
19. Phenylalanine side chain behavior of the intestinal fatty acid-binding protein: the effect of urea on backbone and side chain stability. Li H and Frieden C, J Biol Chem. 2005 Nov 18;280(46):38556-61. Epub 2005 Sep 14.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. Lack of association between the fatty acid binding protein 2 (FABP2) polymorphism with obesity and insulin resistance in two aboriginal populations from Chile. Perez-Bravo F, etal., Acta Diabetol. 2006 Dec;43(4):93-8.
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. The role of FABP2 gene polymorphism in alcoholic cirrhosis. Salguero ML, etal., Hepatol Res. 2005 Nov 8;.
27. Chronic leptin administration decreases fatty acid uptake and fatty acid transporters in rat skeletal muscle. Steinberg GR, etal., J Biol Chem 2002 Mar 15;277(11):8854-60.
28. Thr54 allele of the FABP2 gene affects resting metabolic rate and visceral obesity. Takakura Y, etal., Diabetes Res Clin Pract. 2005 Jan;67(1):36-42.
29. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
30. Thr54 allele carriers of the Ala54Thr variant of FABP2 gene have associations with metabolic syndrome and hypertriglyceridemia in urban South Indians. Vimaleswaran KS, etal., Metabolism. 2006 Sep;55(9):1222-6.
31. Genetic variation of the intestinal fatty acid-binding protein 2 gene in carotid atherosclerosis. Wanby P, etal., Vasc Med. 2005 May;10(2):103-8.
32. Genetic risk for coronary artery disease in individuals with or without type 2 diabetes. Yamada Y, etal., Mol Genet Metab. 2004 Apr;81(4):282-90.
33. Effect of Creosote Bush-Derived NDGA on Expression of Genes Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats: Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic Steatosis. Zhang H, etal., PLoS One. 2015 Sep 22;10(9):e0138203. doi: 10.1371/journal.pone.0138203. eCollection 2015.
Additional References at PubMed
PMID:1739433   PMID:1740465   PMID:2671390   PMID:2682622   PMID:2824476   PMID:9139712   PMID:10082380   PMID:10692339   PMID:12809510   PMID:15277733   PMID:16921753   PMID:17615232  
PMID:18284926   PMID:19160019   PMID:19309727   PMID:19844951   PMID:22554584   PMID:24148314   PMID:25311169   PMID:26012957   PMID:29600311   PMID:30845287   PMID:33884597  


Genomics

Comparative Map Data
Fabp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82213,724,629 - 213,728,686 (+)NCBIGRCr8
mRatBN7.22211,040,032 - 211,044,089 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2211,040,032 - 211,044,089 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2218,717,756 - 218,721,725 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02216,625,543 - 216,629,512 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02211,471,755 - 211,475,828 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02227,080,912 - 227,083,654 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2227,080,924 - 227,083,501 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02246,442,292 - 246,445,034 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42219,591,502 - 219,605,097 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12219,554,563 - 219,568,159 (+)NCBI
Celera2203,465,826 - 203,473,400 (+)NCBICelera
RH 3.4 Map21537.1RGD
Cytogenetic Map2q42NCBI
FABP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384119,317,250 - 119,322,138 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4119,317,250 - 119,322,138 (-)EnsemblGRCh38hg38GRCh38
GRCh374120,238,405 - 120,243,293 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364120,457,853 - 120,462,766 (-)NCBINCBI36Build 36hg18NCBI36
Build 344120,596,008 - 120,600,921NCBI
Celera4117,600,001 - 117,604,911 (-)NCBICelera
Cytogenetic Map4q26NCBI
HuRef4115,960,235 - 115,965,143 (-)NCBIHuRef
CHM1_14120,214,972 - 120,219,883 (-)NCBICHM1_1
T2T-CHM13v2.04122,622,352 - 122,627,246 (-)NCBIT2T-CHM13v2.0
Fabp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393122,688,721 - 122,693,155 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3122,688,721 - 122,693,155 (+)EnsemblGRCm39 Ensembl
GRCm383122,895,072 - 122,899,506 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3122,895,072 - 122,899,506 (+)EnsemblGRCm38mm10GRCm38
MGSCv373122,598,310 - 122,602,424 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363122,887,414 - 122,891,528 (+)NCBIMGSCv36mm8
Celera3129,305,754 - 129,309,868 (+)NCBICelera
Cytogenetic Map3G1NCBI
cM Map353.74NCBI
Fabp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542820,930,479 - 20,933,950 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542820,930,512 - 20,933,950 (+)NCBIChiLan1.0ChiLan1.0
FABP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23117,095,776 - 117,098,841 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14117,388,095 - 117,395,765 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04111,505,269 - 111,510,197 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14122,055,544 - 122,060,461 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4122,055,544 - 122,060,461 (-)Ensemblpanpan1.1panPan2
FABP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13238,244,065 - 38,248,093 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
ROS_Cfam_1.03238,465,352 - 38,497,153 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3238,465,346 - 38,492,684 (-)EnsemblROS_Cfam_1.0 Ensembl
Fabp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530167,281,463 - 67,284,661 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936869146,844 - 149,902 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936869146,567 - 149,929 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FABP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8104,464,342 - 104,470,480 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18104,464,342 - 104,468,059 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28112,120,922 - 112,124,639 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FABP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1766,797,832 - 66,803,459 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl766,798,990 - 66,802,738 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603745,658,385 - 45,663,315 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Fabp2
37 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:133
Count of miRNA genes:112
Interacting mature miRNAs:123
Transcripts:ENSRNOT00000029871
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
631203Gluco14Glucose level QTL 140.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)2206665645219003804Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2189599258218414891Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
2299161Iddm33Insulin dependent diabetes mellitus QTL 332.98blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2206312063220876787Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat

Markers in Region
RH94797  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22211,039,803 - 211,040,077 (+)MAPPERmRatBN7.2
Rnor_6.02227,080,684 - 227,080,957NCBIRnor6.0
Rnor_5.02246,442,064 - 246,442,337UniSTSRnor5.0
RGSC_v3.42219,591,274 - 219,591,547UniSTSRGSC3.4
Celera2203,465,598 - 203,465,871UniSTS
Cytogenetic Map2q42UniSTS
PMC61071P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22211,041,422 - 211,041,501 (+)MAPPERmRatBN7.2
Rnor_6.02227,082,303 - 227,082,381NCBIRnor6.0
Rnor_5.02246,443,683 - 246,443,761UniSTSRnor5.0
RGSC_v3.42219,592,893 - 219,592,971UniSTSRGSC3.4
Celera2203,467,217 - 203,467,295UniSTS
Cytogenetic Map2q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 3
Medium 18 35 35 35
Low 115 112 3 112 6 6 11 32 6
Below cutoff 42 54 24 24 24 35 9 40 47 12

Sequence


Ensembl Acc Id: ENSRNOT00000029871   ⟹   ENSRNOP00000030244
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2211,040,032 - 211,044,089 (+)Ensembl
Rnor_6.0 Ensembl2227,080,924 - 227,083,501 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101450   ⟹   ENSRNOP00000093186
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2211,040,032 - 211,044,089 (+)Ensembl
RefSeq Acc Id: NM_013068   ⟹   NP_037200
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82213,724,629 - 213,728,686 (+)NCBI
mRatBN7.22211,040,032 - 211,044,089 (+)NCBI
Rnor_6.02227,080,912 - 227,083,654 (+)NCBI
Rnor_5.02246,442,292 - 246,445,034 (+)NCBI
RGSC_v3.42219,591,502 - 219,605,097 (+)RGD
Celera2203,465,826 - 203,473,400 (+)RGD
Sequence:
RefSeq Acc Id: NP_037200   ⟸   NM_013068
- UniProtKB: P02693 (UniProtKB/Swiss-Prot),   A6HVH4 (UniProtKB/TrEMBL),   A0A0A0MY01 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000030244   ⟸   ENSRNOT00000029871
Ensembl Acc Id: ENSRNOP00000093186   ⟸   ENSRNOT00000101450
Protein Domains
Cytosolic fatty-acid binding proteins

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P02693-F1-model_v2 AlphaFold P02693 1-132 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691728
Promoter ID:EPDNEW_R2253
Type:multiple initiation site
Name:Fabp2_1
Description:fatty acid binding protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02227,080,890 - 227,080,950EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2591 AgrOrtholog
BioCyc Gene G2FUF-51335 BioCyc
Ensembl Genes ENSRNOG00000024947 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055027265 UniProtKB/Swiss-Prot
  ENSRNOG00060002871 UniProtKB/Swiss-Prot
  ENSRNOG00065021935 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000029871.4 UniProtKB/TrEMBL
  ENSRNOT00000101450.1 UniProtKB/Swiss-Prot
  ENSRNOT00055047162 UniProtKB/Swiss-Prot
  ENSRNOT00060004645 UniProtKB/Swiss-Prot
  ENSRNOT00065037350 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.128.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Calycin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FABP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fatty_acid-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ILBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipocln_cytosolic_FA-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25598 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25598 ENTREZGENE
PANTHER PTHR11955 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11955:SF89 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lipocalin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fabp2 PhenoGen
PRINTS FATTYACIDBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FABP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000024947 RatGTEx
  ENSRNOG00055027265 RatGTEx
  ENSRNOG00060002871 RatGTEx
  ENSRNOG00065021935 RatGTEx
Superfamily-SCOP SSF50814 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC212140
UniProt A0A0A0MY01 ENTREZGENE, UniProtKB/TrEMBL
  A6HVH4 ENTREZGENE, UniProtKB/TrEMBL
  FABPI_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-27 Fabp2  fatty acid binding protein 2  Fabp2  fatty acid binding protein 2, intestinal  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Fabp2  fatty acid binding protein 2, intestinal    fatty acid binding protein 1  Name updated 1299863 APPROVED
2002-06-10 Fabp2  Fatty acid binding protein 2      Symbol and Name status set to approved 70586 APPROVED