Uap1l1 (UDP-N-acetylglucosamine pyrophosphorylase 1 like 1) - Rat Genome Database

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Gene: Uap1l1 (UDP-N-acetylglucosamine pyrophosphorylase 1 like 1) Rattus norvegicus
Analyze
Symbol: Uap1l1
Name: UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
RGD ID: 1310630
Description: Predicted to enable UDP-N-acetylglucosamine diphosphorylase activity. Predicted to be involved in UDP-N-acetylglucosamine biosynthetic process. Orthologous to human UAP1L1 (UDP-N-acetylglucosamine pyrophosphorylase 1 like 1); PARTICIPATES IN amino sugar metabolic pathway; nucleotide sugar metabolic pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC296560; UDP-N-acetylhexosamine pyrophosphorylase-like protein 1; UDP-N-acteylglucosamine pyrophosphorylase 1-like 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.238,172,335 - 8,180,505 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,173,216 - 8,180,443 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx311,280,328 - 11,285,601 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0319,866,558 - 19,871,831 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0318,056,401 - 18,061,674 (-)NCBIRnor_WKY
Rnor_6.032,579,250 - 2,584,523 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,579,258 - 2,584,523 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,560,663 - 2,565,936 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,526,396 - 3,531,669 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.133,527,348 - 3,531,629 (-)NCBI
Celera33,001,313 - 3,006,586 (-)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clozapine  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethyl methanesulfonate  (ISO)
fenamidone  (ISO)
finasteride  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
manganese(II) chloride  (EXP)
metformin  (ISO)
methyl methanesulfonate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
ozone  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
rotenone  (EXP,ISO)
silicon dioxide  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
sotorasib  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
trametinib  (ISO)
trichloroethene  (EXP)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Uap1l1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.238,172,335 - 8,180,505 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,173,216 - 8,180,443 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx311,280,328 - 11,285,601 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0319,866,558 - 19,871,831 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0318,056,401 - 18,061,674 (-)NCBIRnor_WKY
Rnor_6.032,579,250 - 2,584,523 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,579,258 - 2,584,523 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,560,663 - 2,565,936 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,526,396 - 3,531,669 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.133,527,348 - 3,531,629 (-)NCBI
Celera33,001,313 - 3,006,586 (-)NCBICelera
Cytogenetic Map3p13NCBI
UAP1L1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389137,077,517 - 137,084,538 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl9137,077,517 - 137,084,539 (+)EnsemblGRCh38hg38GRCh38
GRCh379139,971,969 - 139,978,990 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369139,092,414 - 139,098,812 (+)NCBINCBI36Build 36hg18NCBI36
Celera9110,485,412 - 110,492,449 (+)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9109,431,653 - 109,438,690 (+)NCBIHuRef
CHM1_19140,120,762 - 140,127,799 (+)NCBICHM1_1
T2T-CHM13v2.09149,313,412 - 149,320,433 (+)NCBIT2T-CHM13v2.0
Uap1l1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,251,501 - 25,255,695 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl225,249,901 - 25,255,694 (-)EnsemblGRCm39 Ensembl
GRCm38225,361,489 - 25,365,682 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,359,889 - 25,365,682 (-)EnsemblGRCm38mm10GRCm38
MGSCv37225,217,012 - 25,221,146 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36225,183,501 - 25,187,635 (-)NCBIMGSCv36mm8
MGSCv36225,643,041 - 25,647,175 (-)NCBIMGSCv36mm8
Cytogenetic Map2A3NCBI
Uap1l1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555135,095,068 - 5,101,289 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555135,095,744 - 5,101,170 (+)NCBIChiLan1.0ChiLan1.0
UAP1L1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19137,108,764 - 137,115,793 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9137,108,764 - 137,115,793 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v09108,138,569 - 108,145,644 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
LOC606974
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,528,738 - 48,532,888 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha947,721,753 - 47,726,203 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0949,396,677 - 49,401,108 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1948,172,994 - 48,177,420 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,471,811 - 48,475,118 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,519,013 - 48,523,442 (+)NCBIUU_Cfam_GSD_1.0
Uap1l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,490,506 - 202,496,676 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936669876,803 - 884,560 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936669878,938 - 884,469 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UAP1L1
(Sus scrofa - pig)
No map positions available.
UAP1L1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,106,245 - 1,113,363 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236676534,093 - 11,502 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Uap1l1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624760834,606 - 839,970 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624760834,605 - 839,983 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Uap1l1
8 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:319
Count of miRNA genes:188
Interacting mature miRNAs:221
Transcripts:ENSRNOT00000017373
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 22 9 18 9 29 19 11
Low 1 21 48 41 1 41 8 11 65 6 22 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000017373   ⟹   ENSRNOP00000017373
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,173,216 - 8,180,443 (-)Ensembl
Rnor_6.0 Ensembl32,579,258 - 2,584,523 (-)Ensembl
RefSeq Acc Id: NM_001134516   ⟹   NP_001127988
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,175,210 - 8,180,483 (-)NCBI
Rnor_6.032,579,250 - 2,584,523 (-)NCBI
Rnor_5.032,560,663 - 2,565,936 (-)NCBI
RGSC_v3.433,526,396 - 3,531,669 (-)RGD
Celera33,001,313 - 3,006,586 (-)RGD
Sequence:
RefSeq Acc Id: XR_005501837
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,172,335 - 8,180,505 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001127988 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI68670 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001127988   ⟸   NM_001134516
- UniProtKB: B5DEH4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000017373   ⟸   ENSRNOT00000017373

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B5DEH4-F1-model_v2 AlphaFold B5DEH4 1-507 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691873
Promoter ID:EPDNEW_R2398
Type:initiation region
Name:Uap1l1_1
Description:UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.032,584,458 - 2,584,518EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310630 AgrOrtholog
BioCyc Gene G2FUF-50459 BioCyc
Ensembl Genes ENSRNOG00000012960 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000017373 ENTREZGENE
  ENSRNOP00000017373.5 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017373 ENTREZGENE
  ENSRNOT00000017373.7 UniProtKB/TrEMBL
Gene3D-CATH 3.90.550.10 UniProtKB/TrEMBL
InterPro Nucleotide-diphossugar_trans UniProtKB/TrEMBL
  UDP-sugar_pyrophosphorylase UniProtKB/TrEMBL
  UDPGP_trans UniProtKB/TrEMBL
KEGG Report rno:296560 UniProtKB/TrEMBL
NCBI Gene 296560 ENTREZGENE
PANTHER PTHR11952 UniProtKB/TrEMBL
Pfam UDPGP UniProtKB/TrEMBL
PhenoGen Uap1l1 PhenoGen
Superfamily-SCOP SSF53448 UniProtKB/TrEMBL
UniProt B5DEH4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-13 Uap1l1  UDP-N-acetylglucosamine pyrophosphorylase 1 like 1  Uap1l1  UDP-N-acteylglucosamine pyrophosphorylase 1-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Uap1l1  UDP-N-acteylglucosamine pyrophosphorylase 1-like 1   Uap1l1_predicted  UDP-N-acteylglucosamine pyrophosphorylase 1-like 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Uap1l1_predicted  UDP-N-acteylglucosamine pyrophosphorylase 1-like 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED