P2ry2 (purinergic receptor P2Y2) - Rat Genome Database

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Gene: P2ry2 (purinergic receptor P2Y2) Rattus norvegicus
Analyze
Symbol: P2ry2
Name: purinergic receptor P2Y2
RGD ID: 62088
Description: Enables A1 adenosine receptor binding activity; ATP binding activity; and G protein-coupled UTP receptor activity. Involved in several processes, including positive regulation of penile erection; regulation of presynaptic cytosolic calcium ion concentration; and regulation of secretion by cell. Located in apical plasma membrane and basolateral plasma membrane. Is active in glutamatergic synapse and presynaptic active zone membrane. Colocalizes with early endosome; lysosome; and mitochondrion. Used to study impotence. Orthologous to human P2RY2 (purinergic receptor P2Y2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATP receptor; P2U purinoceptor 1; P2U1; P2Y ATP receptor 2; P2Y purinoceptor 2; P2Y2; purinergic receptor P2Y, G-protein coupled 2; purinergic receptor P2Y, G-protein coupled, 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: P2ry2em6Mcwi   P2ry2em7Mcwi  
Genetic Models: SS-P2ry2em7Mcwi SS-P2ry2em6Mcwi
Is Marker For: Strains:   SD-Tg(Ubc-P2ry2)Besey  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21155,352,050 - 155,367,423 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1155,351,165 - 155,367,632 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1163,337,941 - 163,353,249 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01170,518,048 - 170,533,356 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01163,401,414 - 163,416,730 (-)NCBIRnor_WKY
Rnor_6.01166,031,228 - 166,045,423 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1166,031,272 - 166,037,424 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01172,227,726 - 172,241,921 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41158,440,018 - 158,454,213 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11158,519,034 - 158,533,227 (-)NCBI
Celera1153,434,723 - 153,448,921 (-)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
ATP  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
cyclophosphamide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
fenamidone  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
glycidol  (EXP)
Goe 6976  (EXP)
hydrogen sulfide  (ISO)
ibuprofen  (ISO)
L-methionine  (ISO)
methamphetamine  (ISO)
methylmercury(1+)  (EXP)
N-(3-oxododecanoyl)homoserine lactone  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
paracetamol  (EXP)
paraquat  (EXP)
pentanal  (ISO)
phenformin  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (EXP,ISO)
poly(I:C)  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propanal  (ISO)
quercetin  (ISO)
rotenone  (EXP)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
suramin  (EXP,ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (EXP)
trovafloxacin  (EXP)
urethane  (ISO)
UTP  (EXP,ISO)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
vinclozolin  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Development of a novel transgenic rat overexpressing the P2Y(2) nucleotide receptor using a lentiviral vector. Agca C, etal., J Vasc Res. 2009;46(5):447-58. Epub 2009 Jan 21.
2. P2Y2 receptor up-regulation induced by guanosine or UTP in rat brain cultured astrocytes. Ballerini P, etal., Int J Immunopathol Pharmacol. 2006 Apr-Jun;19(2):293-308.
3. Molecular cloning and functional characterization of a rat pituitary G protein-coupled adenosine triphosphate (ATP) receptor. Chen ZP, etal., Endocrinology 1996 May;137(5):1833-40.
4. Abundant and dynamic expression of G protein-coupled P2Y receptors in mammalian development. Cheung KK, etal., Dev Dyn. 2003 Oct;228(2):254-66.
5. P2Y receptors activate neuroprotective mechanisms in astrocytic cells. Chorna NE, etal., J Neurochem. 2004 Oct;91(1):119-32.
6. Polarized expression and function of P2Y ATP receptors in rat bile duct epithelia. Dranoff JA, etal., Am J Physiol Gastrointest Liver Physiol 2001 Oct;281(4):G1059-67.
7. Long-term exposure to LPS enhances the rate of stimulated exocytosis and surfactant secretion in alveolar type II cells and upregulates P2Y2 receptor expression. Garcia-Verdugo I, etal., Am J Physiol Lung Cell Mol Physiol. 2008 Oct;295(4):L708-17. Epub 2008 Aug 8.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Purinergic receptor expression in the regeneration epidermis in a rat model of normal and delayed wound healing. Greig AV, etal., Exp Dermatol. 2003 Dec;12(6):860-71.
10. Management of erectile function by penile purinergic p2 receptors in the diabetic rat. Gur S, etal., J Urol. 2009 May;181(5):2375-82. Epub 2009 Mar 19.
11. ATP and UTP at low concentrations strongly inhibit bone formation by osteoblasts: a novel role for the P2Y2 receptor in bone remodeling. Hoebertz A, etal., J Cell Biochem 2002;86(3):413-9.
12. Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors. Honda S, etal., J Neurosci. 2001 Mar 15;21(6):1975-82.
13. Comparison of P2 receptor subtypes producing dilation in rat intracerebral arterioles. Horiuchi T, etal., Stroke. 2003 Jun;34(6):1473-8. Epub 2003 May 1.
14. P2Y2 receptor mRNA and protein expression is altered in inner medullas of hydrated and dehydrated rats: relevance to AVP-independent regulation of IMCD function. Kishore BK, etal., Am J Physiol Renal Physiol. 2005 Jun;288(6):F1164-72. Epub 2005 Feb 1.
15. Interleukin-1beta enhances nucleotide-induced and alpha-secretase-dependent amyloid precursor protein processing in rat primary cortical neurons via up-regulation of the P2Y(2) receptor. Kong Q, etal., J Neurochem. 2009 Jun;109(5):1300-10. Epub 2009 Mar 20.
16. Mitochondrial localization of P2Y1, P2Y2 and P2Y12 receptors in rat astrocytes and glioma C6 cells. Krzeminski P, etal., Brain Res Bull. 2007 Mar 30;71(6):587-92. Epub 2006 Dec 22.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Age-related changes in P2 receptor mRNA of rat cerebral arteries. Miao LY, etal., Exp Gerontol. 2001 Dec;37(1):67-79.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. Nucleotide receptors involved in UTP-induced rat arterial smooth muscle cell migration. Pillois X, etal., Circ Res 2002 Apr 5;90(6):678-81.
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y1, P2Y2, and/or P2Y4 receptors in the rat hippocampus. Rodrigues RJ, etal., J Neurosci. 2005 Jul 6;25(27):6286-95.
25. Overexpression of P2Y2 purinoceptor in intimal lesions of the rat aorta. Seye CI, etal., Arterioscler Thromb Vasc Biol 1997 Dec;17(12):3602-10.
26. Purinergic P2Y2 receptors induce increased MCP-1/CCL2 synthesis and release from rat alveolar and peritoneal macrophages. Stokes L and Surprenant A, J Immunol. 2007 Nov 1;179(9):6016-23.
27. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
28. P2Y2 receptor-mediated release of prostaglandin E2 by IMCD is altered in hydrated and dehydrated rats: relevance to AVP-independent regulation of IMCD function. Sun R, etal., Am J Physiol Renal Physiol. 2005 Sep;289(3):F585-92. Epub 2005 Apr 19.
29. Endocytosis mechanism of P2Y2 nucleotide receptor tagged with green fluorescent protein: clathrin and actin cytoskeleton dependence. Tulapurkar ME, etal., Cell Mol Life Sci. 2005 Jun;62(12):1388-99.
30. Inhibitory, facilitatory, and excitatory effects of ATP and purinergic receptor agonists on the activity of rat cutaneous nociceptors in vitro. Yajima H, etal., Neurosci Res. 2005 Apr;51(4):405-16. Epub 2005 Jan 20.
31. Heteromeric association creates a P2Y-like adenosine receptor. Yoshioka K, etal., Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7617-22. Epub 2001 Jun 5.
Additional References at PubMed
PMID:7811468   PMID:12850289   PMID:14764443   PMID:15258260   PMID:15489334   PMID:16075244   PMID:16135088   PMID:16365320   PMID:16597733   PMID:17599409   PMID:17728398   PMID:18216148  
PMID:18337312   PMID:19140137   PMID:19191015   PMID:19244398   PMID:20007349   PMID:20619335   PMID:21296070   PMID:21300137   PMID:21487675   PMID:22733659   PMID:23249537   PMID:23592515  
PMID:23620825   PMID:23828651   PMID:24642246   PMID:24760984   PMID:24771361   PMID:26070527   PMID:26531757   PMID:28468962   PMID:28828576   PMID:30273839   PMID:30624816   PMID:31173231  
PMID:32751703   PMID:34780922   PMID:35154311  


Genomics

Comparative Map Data
P2ry2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21155,352,050 - 155,367,423 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1155,351,165 - 155,367,632 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1163,337,941 - 163,353,249 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01170,518,048 - 170,533,356 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01163,401,414 - 163,416,730 (-)NCBIRnor_WKY
Rnor_6.01166,031,228 - 166,045,423 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1166,031,272 - 166,037,424 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01172,227,726 - 172,241,921 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41158,440,018 - 158,454,213 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11158,519,034 - 158,533,227 (-)NCBI
Celera1153,434,723 - 153,448,921 (-)NCBICelera
Cytogenetic Map1q32NCBI
P2RY2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381173,218,281 - 73,242,427 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1173,218,281 - 73,242,427 (+)EnsemblGRCh38hg38GRCh38
GRCh371172,929,326 - 72,953,472 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361172,606,992 - 72,625,045 (+)NCBINCBI36Build 36hg18NCBI36
Build 341172,606,991 - 72,625,041NCBI
Celera1170,233,951 - 70,251,998 (+)NCBICelera
Cytogenetic Map11q13.4NCBI
HuRef1169,224,261 - 69,248,426 (+)NCBIHuRef
CHM1_11172,813,103 - 72,837,239 (+)NCBICHM1_1
T2T-CHM13v2.01173,146,472 - 73,170,656 (+)NCBIT2T-CHM13v2.0
P2ry2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397100,645,775 - 100,661,260 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7100,645,775 - 100,662,073 (-)EnsemblGRCm39 Ensembl
GRCm387100,996,568 - 101,012,053 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7100,996,568 - 101,012,866 (-)EnsemblGRCm38mm10GRCm38
MGSCv377108,145,086 - 108,160,505 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367100,870,659 - 100,886,078 (-)NCBIMGSCv36mm8
Celera7101,348,339 - 101,363,985 (-)NCBICelera
Cytogenetic Map7E2NCBI
P2ry2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541418,248,082 - 18,260,450 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541418,248,082 - 18,271,047 (-)NCBIChiLan1.0ChiLan1.0
P2RY2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11171,517,063 - 71,541,109 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1171,532,958 - 71,534,091 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01168,294,366 - 68,319,118 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
P2RY2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12124,987,568 - 25,009,754 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2124,992,848 - 24,996,059 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2124,753,351 - 24,793,458 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02125,195,604 - 25,235,719 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2125,195,629 - 25,216,051 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12124,989,138 - 25,029,222 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02125,190,157 - 25,231,835 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02125,105,502 - 25,145,605 (-)NCBIUU_Cfam_GSD_1.0
P2ry2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494760,831,899 - 60,845,324 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364982,432,448 - 2,444,354 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049364982,432,436 - 2,444,495 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
P2RY2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl97,672,403 - 7,695,163 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.197,672,294 - 7,695,085 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
P2RY2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1164,461,929 - 64,481,429 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl164,479,642 - 64,480,775 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604361,405,464 - 61,424,948 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
P2ry2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248173,706,017 - 3,719,649 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248173,706,017 - 3,721,045 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in P2ry2
93 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:192
Count of miRNA genes:144
Interacting mature miRNAs:154
Transcripts:ENSRNOT00000026115
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642722214537671Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1131763437159756369Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1136745990163747690Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383635Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1144267916172949660Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144267916174133260Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat

Markers in Region
PMC96855P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21155,353,908 - 155,354,686 (+)MAPPERmRatBN7.2
Rnor_6.01166,031,921 - 166,032,698NCBIRnor6.0
Rnor_5.01172,228,419 - 172,229,196UniSTSRnor5.0
RGSC_v3.41158,440,711 - 158,441,488UniSTSRGSC3.4
Celera1153,435,416 - 153,436,193UniSTS
Cytogenetic Map1q32UniSTS


Related Rat Strains
The following Strains have been annotated to P2ry2


Genetic Models
This gene P2ry2 is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 23 23 6 23 8 11 15 10 8
Low 3 43 34 18 13 18 25 35 22 1
Below cutoff 47 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000026115   ⟹   ENSRNOP00000026115
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1155,352,068 - 155,363,697 (-)Ensembl
Rnor_6.0 Ensembl1166,031,272 - 166,037,424 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114931   ⟹   ENSRNOP00000077949
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1155,351,165 - 155,367,632 (-)Ensembl
RefSeq Acc Id: NM_017255   ⟹   NP_058951
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21155,352,050 - 155,367,423 (-)NCBI
Rnor_6.01166,031,228 - 166,045,423 (-)NCBI
Rnor_5.01172,227,726 - 172,241,921 (-)NCBI
RGSC_v3.41158,440,018 - 158,454,213 (-)RGD
Celera1153,434,723 - 153,448,921 (-)RGD
Sequence:
RefSeq Acc Id: XM_006229757   ⟹   XP_006229819
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21155,352,050 - 155,367,102 (-)NCBI
Rnor_6.01166,031,272 - 166,045,155 (-)NCBI
Rnor_5.01172,227,726 - 172,241,921 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039109599   ⟹   XP_038965527
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21155,352,050 - 155,364,030 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_058951   ⟸   NM_017255
- UniProtKB: G3V8H8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229819   ⟸   XM_006229757
- Peptide Label: isoform X1
- UniProtKB: G3V8H8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000026115   ⟸   ENSRNOT00000026115
RefSeq Acc Id: XP_038965527   ⟸   XM_039109599
- Peptide Label: isoform X1
- UniProtKB: G3V8H8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000077949   ⟸   ENSRNOT00000114931
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P41232-F1-model_v2 AlphaFold P41232 1-374 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62088 AgrOrtholog
BioCyc Gene G2FUF-58309 BioCyc
Ensembl Genes ENSRNOG00000019283 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000026115 ENTREZGENE
  ENSRNOP00000026115.3 UniProtKB/TrEMBL
  ENSRNOP00000077949 ENTREZGENE
  ENSRNOP00000077949.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026115 ENTREZGENE
  ENSRNOT00000026115.6 UniProtKB/TrEMBL
  ENSRNOT00000114931 ENTREZGENE
  ENSRNOT00000114931.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5599916 IMAGE-MGC_LOAD
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2Y2_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29597 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72498 IMAGE-MGC_LOAD
NCBI Gene 29597 ENTREZGENE
PANTHER PTHR24231:SF17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB P2RY2 RGD
PhenoGen P2ry2 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2Y2PRNOCPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2YPURNOCPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G3V8H8 ENTREZGENE, UniProtKB/TrEMBL
  P2RY2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 P2ry2  purinergic receptor P2Y2  P2ry2  purinergic receptor P2Y, G-protein coupled, 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-01-14 P2ry2  purinergic receptor P2Y, G-protein coupled, 2  P2ry2  purinergic receptor P2Y, G-protein coupled 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 P2ry2  purinergic receptor P2Y, G-protein coupled 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the apical plasma membrane and basolateral domains 628452
gene_expression highly expressed in the neointima of injured arteries 729586
gene_expression mRNA present in holangiocytes, hepatocytes and epithelial cells 628452
gene_process mediates vasomotor responses, neurotransmission, platelet aggregation, and secretion 628452
gene_protein 374 amino acids 729586
gene_regulation activated by ADP and UTP 729586
gene_regulation activated mainly by ADP and UTP 628452