Ripk2 (receptor-interacting serine-threonine kinase 2)

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Gene: Ripk2 (receptor-interacting serine-threonine kinase 2) Rattus norvegicus

Analyze

Symbol:

Ripk2

Name:

receptor-interacting serine-threonine kinase 2

RGD ID:

1309167

Description:

Predicted to enable several functions, including JUN kinase kinase kinase activity; caspase binding activity; and protein domain specific binding activity. Predicted to be involved in several processes, including cellular response to muramyl dipeptide; defense response to other organism; and positive regulation of protein modification process. Predicted to act upstream of or within several processes, including positive regulation of cytokine production; positive regulation of immune response; and response to bacterium. Predicted to be located in cytoskeleton; cytosol; and vesicle. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Orthologous to human RIPK2 (receptor interacting serine/threonine kinase 2); PARTICIPATES IN interleukin-12 signaling pathway; nuclear factor kappa B signaling pathway; neurotrophic factor signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; aconitine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC362491; receptor (TNFRSF)-interacting serine-threonine kinase 2; receptor-interacting serine/threonine-protein kinase 2

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	29,630,806 - 29,662,804 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	29,631,570 - 29,662,657 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	31,792,628 - 31,823,715 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	33,385,294 - 33,416,381 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	33,345,474 - 33,376,561 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	29,838,713 - 29,870,390 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	29,838,747 - 29,870,735 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	34,512,111 - 34,543,807 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	30,714,817 - 30,745,941 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	30,715,463 - 30,738,284 (-)	NCBI
Celera	5	28,836,598 - 28,867,674 (-)	NCBI		Celera
Cytogenetic Map	5	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

leprosy (ISO)

ulcerative colitis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (EXP)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-methylcholine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4-hydroxyphenyl retinamide (ISO)

6alpha-methylprednisolone (ISO)

aconitine (EXP,ISO)

all-trans-retinoic acid (ISO)

aristolochic acid A (ISO)

azathioprine (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

beta-naphthoflavone (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (EXP)

caffeine (ISO)

calcitriol (ISO)

capsaicin (ISO)

chlorpyrifos (ISO)

cholesterol (EXP)

cisplatin (ISO)

cobalt atom (ISO)

copper(II) sulfate (ISO)

corn oil (ISO)

coumarin (ISO)

crocidolite asbestos (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

DDE (EXP)

deoxynivalenol (ISO)

dicrotophos (ISO)

dieldrin (EXP)

doxorubicin (ISO)

enzyme inhibitor (ISO)

ethanol (ISO)

etoposide (ISO)

fipronil (EXP)

fluoranthene (ISO)

flutamide (EXP)

folic acid (ISO)

furan (EXP)

gentamycin (EXP)

lamivudine (ISO)

lead(0) (ISO)

lipopolysaccharide (ISO)

metam (ISO)

metformin (ISO)

methotrexate (ISO)

methylisothiazolinone (ISO)

methylmercury chloride (ISO)

Mitotane (EXP)

N-acetyl-L-cysteine (EXP)

nickel dichloride (ISO)

nickel sulfate (ISO)

ochratoxin A (ISO)

p-menthan-3-ol (ISO)

paclitaxel (ISO)

paracetamol (EXP)

paraquat (ISO)

perfluorononanoic acid (ISO)

phenethyl isothiocyanate (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

piroxicam (ISO)

prednisolone (ISO)

propylparaben (ISO)

pyrethrins (ISO)

quercetin (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

serpentine asbestos (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium aurothiomalate (ISO)

Soman (EXP)

sulfasalazine (ISO)

tert-butyl hydroperoxide (ISO)

thapsigargin (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (ISO)

Triptolide (EXP)

triptonide (ISO)

troglitazone (ISO)

Tungsten carbide (ISO)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

vincristine (ISO)

zidovudine (ISO)

zinc oxide (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adaptive immune response (ISO)

apoptotic process (ISO)

canonical NF-kappaB signal transduction (ISO)

CD4-positive, alpha-beta T cell proliferation (ISO)

cellular response to lipopolysaccharide (ISO)

cellular response to lipoteichoic acid (ISO)

cellular response to muramyl dipeptide (ISO)

cellular response to peptidoglycan (ISO)

cytokine-mediated signaling pathway (ISO)

defense response to bacterium (ISO)

defense response to Gram-positive bacterium (ISO)

ERK1 and ERK2 cascade (ISO)

immature T cell proliferation in thymus (ISO)

innate immune response (IBA,ISO)

JNK cascade (ISO)

lipopolysaccharide-mediated signaling pathway (ISO)

nucleotide-binding oligomerization domain containing 1 signaling pathway (ISO)

nucleotide-binding oligomerization domain containing 2 signaling pathway (ISO)

phosphorylation (IEA)

positive regulation of apoptotic process (ISO)

positive regulation of canonical NF-kappaB signal transduction (IBA,ISO)

positive regulation of CD4-positive, alpha-beta T cell proliferation (ISO)

positive regulation of chemokine production (ISO)

positive regulation of cytokine-mediated signaling pathway (ISO)

positive regulation of ERK1 and ERK2 cascade (ISO)

positive regulation of immature T cell proliferation in thymus (ISO)

positive regulation of interleukin-1 beta production (ISO)

positive regulation of interleukin-2 production (ISO)

positive regulation of interleukin-6 production (ISO)

positive regulation of JNK cascade (ISO)

positive regulation of macrophage cytokine production (ISO)

positive regulation of peptidyl-serine phosphorylation (ISO)

positive regulation of peptidyl-threonine phosphorylation (ISO)

positive regulation of peptidyl-tyrosine phosphorylation (ISO)

positive regulation of protein K63-linked ubiquitination (ISO)

positive regulation of protein ubiquitination (ISO)

positive regulation of stress-activated MAPK cascade (ISO)

positive regulation of T-helper 1 cell differentiation (ISO)

positive regulation of T-helper 1 type immune response (ISO)

positive regulation of tumor necrosis factor production (ISO)

positive regulation of type II interferon production (ISO)

positive regulation of xenophagy (ISO)

protein homooligomerization (ISO)

response to exogenous dsRNA (ISO)

response to interleukin-1 (ISO)

response to interleukin-12 (ISO)

response to interleukin-18 (ISO)

stress-activated MAPK cascade (ISO)

T cell proliferation (ISO)

T cell receptor signaling pathway (ISO)

toll-like receptor 2 signaling pathway (ISO)

toll-like receptor 4 signaling pathway (ISO)

xenophagy (ISO)

Cellular Component

cytoplasm (ISO)

cytoskeleton (ISO)

cytosol (IEA,ISO)

plasma membrane (ISO)

protein-containing complex (ISO)

vesicle (ISO)

Molecular Function

ATP binding (IEA)

CARD domain binding (ISO)

caspase binding (ISO)

identical protein binding (ISO)

JUN kinase kinase kinase activity (IBA)

LIM domain binding (ISO)

protein binding (ISO)

protein homodimerization activity (ISO)

protein serine/threonine kinase activity (ISO)

signaling adaptor activity (ISO)

signaling receptor binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

interleukin-12 signaling pathway (ISO)

neurotrophic factor signaling pathway (IEA)

NOD-like receptor signaling pathway (IEA)

nuclear factor kappa B signaling pathway (ISO)

tuberculosis pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10329646	PMID:11087742	PMID:11432859	PMID:11536016	PMID:11821383	PMID:11894097	PMID:11894098	PMID:12477932	PMID:14638696	PMID:14663141	PMID:14743216	PMID:15190255
PMID:15383541	PMID:15620648	PMID:15657077	PMID:16920334	PMID:18261938	PMID:19337385	PMID:21469090	PMID:21887730	PMID:21931591	PMID:22033934	PMID:23806334	PMID:24790089
PMID:25416956	PMID:26138652	PMID:27169686	PMID:30352081	PMID:37128885

Genomics

Comparative Map Data

Ripk2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	29,630,806 - 29,662,804 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	29,631,570 - 29,662,657 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	31,792,628 - 31,823,715 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	33,385,294 - 33,416,381 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	33,345,474 - 33,376,561 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	29,838,713 - 29,870,390 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	29,838,747 - 29,870,735 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	34,512,111 - 34,543,807 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	30,714,817 - 30,745,941 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	30,715,463 - 30,738,284 (-)	NCBI
Celera	5	28,836,598 - 28,867,674 (-)	NCBI		Celera
Cytogenetic Map	5	q13	NCBI

RIPK2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	89,757,816 - 89,791,064 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	89,757,806 - 89,791,064 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	90,770,044 - 90,803,292 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	90,839,110 - 90,872,433 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	90,839,172 - 90,872,432	NCBI
Celera	8	86,964,831 - 86,998,139 (+)	NCBI		Celera
Cytogenetic Map	8	q21.3	NCBI
HuRef	8	85,980,380 - 86,013,697 (+)	NCBI		HuRef
CHM1_1	8	90,811,006 - 90,844,310 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	90,880,976 - 90,914,226 (+)	NCBI		T2T-CHM13v2.0

Ripk2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	16,122,740 - 16,163,674 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	16,122,733 - 16,163,647 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	16,122,732 - 16,163,678 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	16,122,733 - 16,163,647 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	16,050,522 - 16,090,645 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	16,050,522 - 16,090,647 (-)	NCBI		MGSCv36	mm8
Celera	4	15,919,468 - 15,959,561 (-)	NCBI		Celera
Cytogenetic Map	4	A2	NCBI
cM Map	4	6.7	NCBI

Ripk2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955417	6,669,675 - 6,702,228 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955417	6,669,675 - 6,698,142 (+)	NCBI	ChiLan1.0	ChiLan1.0

RIPK2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	8	82,693,378 - 82,735,495 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	86,447,216 - 86,480,511 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	88,397,768 - 88,431,690 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	88,398,468 - 88,456,268 (+)	Ensembl	panpan1.1		panPan2

RIPK2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	29	35,283,209 - 35,311,608 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	29	35,282,072 - 35,311,333 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	29	35,435,813 - 35,464,812 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	29	35,480,726 - 35,509,728 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	29	35,479,776 - 35,509,034 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	29	35,472,061 - 35,501,046 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	29	35,492,803 - 35,521,758 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	29	35,926,135 - 35,955,236 (+)	NCBI		UU_Cfam_GSD_1.0

Ripk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	44,137,166 - 44,185,801 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936544	3,606,879 - 3,655,532 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936544	3,606,925 - 3,653,248 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RIPK2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	47,027,098 - 47,074,704 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	47,026,558 - 47,075,133 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	51,491,234 - 51,539,306 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RIPK2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	84,843,391 - 84,881,087 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	84,843,471 - 84,881,303 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666039	55,998,663 - 56,036,344 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ripk2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624744	2,201,319 - 2,226,890 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624744	2,194,339 - 2,227,498 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ripk2
154 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	127
Count of miRNA genes:	97
Interacting mature miRNAs:	117
Transcripts:	ENSRNOT00000012963
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331756	Rf34	Renal function QTL 34	4.16275		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	1	90450412	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	1	131345958	Rat
1331771	Rf35	Renal function QTL 35	4.36965		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	729470	86724018	Rat
2312562	Pur18	Proteinuria QTL 18	2.6	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	5	2138965	32656739	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
8662454	Vetf3	Vascular elastic tissue fragility QTL 3	27.4		artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	5	2282226	69540447	Rat
1300117	Hrtrt8	Heart rate QTL 8	3.49		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	5	3844018	47869213	Rat
61462	Niddm10	Non-insulin dependent diabetes mellitus QTL 10	3.9	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	5	5112159	47171491	Rat
2293666	Bmd38	Bone mineral density QTL 38	4.4		femur size trait (VT:1000369)	femoral neck cortical cross-sectional area (CMO:0001702)	5	8948228	53948228	Rat
7394712	Emca13	Estrogen-induced mammary cancer QTL 13			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	9823266	99753708	Rat
1641903	Alcrsp3	Alcohol response QTL 3			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	12689285	57689285	Rat
634305	Mamtr1	Mammary tumor resistance QTL 1		0.0001	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	12789751	113558310	Rat
1600358	Mamtr5	Mammary tumor resistance QTL 5			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	18873947	63873947	Rat
1358353	Srcrtb2	Stress Responsive Cort Basal QTL 2	3.48	0.003	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	18873947	74251464	Rat
8552954	Pigfal14	Plasma insulin-like growth factor 1 level QTL 14	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	21226744	66226744	Rat
1549901	Neudeg2	Neurodegradation QTL 2	4	0	nervous system integrity trait (VT:0010566)	mononuclear cell count (CMO:0002119)	5	24838710	44045280	Rat
1578767	Stresp17	Stress response QTL 17	4.3	0.01	blood aldosterone amount (VT:0005346)	plasma aldosterone level (CMO:0000551)	5	27955440	72955440	Rat
1578776	Stresp18	Stress response QTL 18	2.9		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	5	27955440	72955440	Rat
6903292	Stl28	Serum triglyceride level QTL 28	2.6	0.0073	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	5	28515489	73515489	Rat
6903306	Scl35	Serum cholesterol QTL 35	2.6	0.0073	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	28515489	73515489	Rat

Markers in Region

RH144493

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	29,631,649 - 29,631,831 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	29,839,557 - 29,839,738	NCBI	Rnor6.0
Rnor_5.0	5	34,512,955 - 34,513,136	UniSTS	Rnor5.0
RGSC_v3.4	5	30,714,897 - 30,715,078	UniSTS	RGSC3.4
Celera	5	28,836,678 - 28,836,859	UniSTS
RH 3.4 Map	5	161.12	UniSTS
Cytogenetic Map	5	q13	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	1		6		17				8		11	10
Low	2	43	51	41	2	41	8	11	66	35	30	1	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001191865	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017593470	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039110221	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005504472	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005504473	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC107468	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473962	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ230093	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000161	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000012963 ⟹ ENSRNOP00000012963

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	29,631,570 - 29,662,657 (-)	Ensembl
Rnor_6.0 Ensembl	5	29,838,747 - 29,870,735 (-)	Ensembl

RefSeq Acc Id:

NM_001191865 ⟹ NP_001178794

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	29,631,570 - 29,662,657 (-)	NCBI
Rnor_6.0	5	29,839,477 - 29,870,390 (-)	NCBI
Rnor_5.0	5	34,512,111 - 34,543,807 (-)	NCBI
Celera	5	28,836,598 - 28,867,674 (-)	NCBI

Sequence:

show sequence

CGGCCGCAGACCCGACGGGCTCCCAGGGACAGCCGGCCGGGCCGGAACTGCAGAGAATGGGCCG
CCCCGGGACCTAGCGCACCGCAGCACGGGCCGCGGCCAGGGTCGGGCGGAGCCGCTGCGCAGCT
GGAGCCATGAACGGGGACGCCATCTGCAGCGCGCTGCCCCACATCCCCTACCACAAGCTCGCCG
ACCTGCACTACCTCAGCCGCGGCGCCTCAGGCACCGTCTCGTCGGCAAGACACGCGGACTGGCG
GGTGCGGGTGGCAGTGAAGCACCTGCACATTCACACGCCGCTGCTCGACAGTGAAAGAAATGAT
ATCTTACGAGAAGCCGAAATATTACATAAAGCAAGATTTAGTTACATTCTTCCAATATTGGGAA
TTTGCAATGAGCCTGAATTTTTGGGCATAGTTACTGAATACATGCCAAACGGATCATTAAATGA
GCTTCTACACAGAAAAACTGAATATCCTGAGATTGCATGGCCATTGAGATTCCGCATCCTGCAT
GAAATTGCTCTTGGTGTAAATTACCTGCACAATATGAACCCCCCTCTGCTTCATCATGACTTAA
AGACTCAGAATATCTTGTTGGATAATGAATTTCATGTTAAGATTGCAGATTTCGGTTTATCAAA
ATGGCGCATGATGTCACTCTCCCAATCACGGAGCTACAAATCTGCACCCGAAGGGGGAACGATC
ATCTATATGCCACCTGAGAACTATGAACCGGGACAGAAATCAAGGGCCAGCGTGAAGCATGATA
TATACAGCTATGCGGTTATCATGTGGGAAGTGTTGTCCAGAAAACAGCCTTTTGAAGAGGTCAC
CAATCCTTTGCAGATCATGTACAGTGTGTCCCAGGGACATCGGCCTAACACCAGTGAGGAAAAT
TTGCCATTTGATATACCTCATCGAGGTCTCATGATCTCTCTAATACAAAGTGGATGGGCACAAA
ACCCAGATGAGAGACCATCCTTCTTGAAATGCTTAATAGAACTTGAACCAGTTCTGAGAACATT
TGAAGACATAACTTTTCTTGAAGCTGTTATTCAGCTAAAAAAATCAAAGATACAGAGTGCATCG
AGTACAATTCACTTATGTGATAAGAAAATGGATTTATCACTGAACATACCTGCAAGCCATCCTC
CACAGGAGGAATCATGTGGATCCTCTCTGCTCTCTAGAAACGCTGGTTCTCCTGGAACCTCCAG
GTCTCTGTCAGCTCCTCAAGACAAAGGTTTTTTCCATGGAGGACCTCAAGACTGTTCTTCGTCG
AAGGCGTACCATTGTCCTGGAAATCACAGCTGGGATGGTATCATTTCTGTGTCACAAGAGGCAG
CCTTCTGTGATCGCAGAGCCAGCTCGTGCTCCTTGACTGTGATAAGGCCACTGTTGGTTGAGAA
AAGTTCAGAGCGCCCACAACCCGGGATAGCACAACAGTGGATCCAGAGTAAGAGGGAAGCCATT
GTGAGCCAGATGACTGAAGCCTGCCTGAACCAATCCCTGGACGCCCTTCTGTCTCGGGACCTGA
TCATGAAGGAGGACTATGAACTCATTAGCACCAAACCTACAAGGACCGCAAAAGTCAGACAGCT
GCTAGATACCTCTGACATCCAAGGAGAAGAGTTTGCCAGAGTTATAGTACAGAAGTTGAAAGAC
AACAAGCAGATGGGGCTTCAGCCTTACCCGGAAGTACTTTTGGTTTCCAGAACACCATCTTCAA
ATGTCCTTCAAAATAAAACCTTATAAGGGGGCCTTCTTTGAGGGGAAAGTCGGTTTACAAATGA
TTATTTATATTTCTGTTACCTGTATAATATTTGTATAAAAACATGAGAGTATTAGATGCTTCAG
TGAAGGTTTTTGGAAGAGTCTCTTCCCATGACGTTGCAGTATTTTTTTTTAAATTAATATAAGT
AAAAAGTTTGCATTATGCTGTGTAGTTCAGTTTTTATGTCAGCTTCACTACTTGAACTTTTTTT
TAATGTGATAATCACATTTTTCTTATATGTAACAAGCCTTCGTTTCTGATGGAAGACATTTTCC
CACTCACCTGACCTGTGGATTCCTCATTATTCCTCTAAAGTGCGGTTTGACATTACATAGCAGT
GATATGGTGTTGCCCCTCTGCAACCCCAAGTTCAGATCTCCAGAGAGTTACTCATTTTTAAATT
TGATTTACAAATTCTTTAGAAGGTGGTTTCAAGGAATACAAAGTGTATAAAGAAGAAAAAAAAG
AGAGAGAGAGAGAATCTTTTACTAACACTGGCCGTCCGTGTACCTCTGCTTGACCTTTGCCTCC
TGTCTTTCTCCAGAGCAAGCAGCCCATTGTGTATCCTGCTGCAGCCTGCTTCCGGCTCCTATTT
TAAGAATATGCTGGTTGGGTAGAGGCCGGCCTTTGCTTCGCTATTTCCTTTGTAACACACCATG
GTTTTTGAACTGAAGGGTACATCCGGTGTCTCCCCCAGCTCACCTAACTAACTCCGTTCAATTA
CCGCACAGCGGCCATGCCTCTCTGTGTTTGCTTTTCCAAGCGTGTTCTCAACTTCACGACAAAC
AATAAAAAGGCAATACAGTGTG

hide sequence

RefSeq Acc Id:

XM_017593470 ⟹ XP_017448959

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	29,630,806 - 29,662,339 (-)	NCBI
Rnor_6.0	5	29,838,713 - 29,870,077 (-)	NCBI

Sequence:

show sequence

CGCGGACGTGGGACCCCACGCAAGTGCGGGCCGACGCGTTATCATCCTGACCGCACTGATGGTG
ATGCGCCGGCTCCGCCGCGGCGAGTCCTTAAGTTTTTGGGCTATCCTGGCCCAAGAGAGAAATT
GTCCTGGACCTGCGTCAGACTTCGCAACTCGCCTCTCCACCGCCCTGCCTCTCCTCCCATCCAA
GTGAAAGAAATGATATCTTACGAGAAGCCGAAATATTACATAAAGCAAGATTTAGTTACATTCT
TCCAATATTGGGAATTTGCAATGAGCCTGAATTTTTGGGCATAGTTACTGAATACATGCCAAAC
GGATCATTAAATGAGCTTCTACACAGAAAAACTGAATATCCTGAGATTGCATGGCCATTGAGAT
TCCGCATCCTGCATGAAATTGCTCTTGGTGTAAATTACCTGCACAATATGAACCCCCCTCTGCT
TCATCATGACTTAAAGACTCAGAATATCTTGTTGGATAATGAATTTCATGTTAAGATTGCAGAT
TTCGGTTTATCAAAATGGCGCATGATGTCACTCTCCCAATCACGGAGCTACAAATCTGCACCCG
AAGGGGGAACGATCATCTATATGCCACCTGAGAACTATGAACCGGGACAGAAATCAAGGGCCAG
CGTGAAGCATGATATATACAGCTATGCGGTTATCATGTGGGAAGTGTTGTCCAGAAAACAGCCT
TTTGAAGAGGTCACCAATCCTTTGCAGATCATGTACAGTGTGTCCCAGGGACATCGGCCTAACA
CCAGTGAGGAAAATTTGCCATTTGATATACCTCATCGAGGTCTCATGATCTCTCTAATACAAAG
TGGATGGGCACAAAACCCAGATGAGAGACCATCCTTCTTGAAATGCTTAATAGAACTTGAACCA
GTTCTGAGAACATTTGAAGACATAACTTTTCTTGAAGCTGTTATTCAGCTAAAAAAATCAAAGA
TACAGAGTGCATCGAGTACAATTCACTTATGTGATAAGAAAATGGATTTATCACTGAACATACC
TGCAAGCCATCCTCCACAGGAGGAATCATGTGGATCCTCTCTGCTCTCTAGAAACGCTGGTTCT
CCTGGAACCTCCAGGTCTCTGTCAGCTCCTCAAGACAAAGGTTTTTTCCATGGAGGACCTCAAG
ACTGTTCTTCGTCGAAGGCGTACCATTGTCCTGGAAATCACAGCTGGGATGGTATCATTTCTGT
GTCACAAGAGGCAGCCTTCTGTGATCGCAGAGCCAGCTCGTGCTCCTTGACTGTGATAAGGCCA
CTGTTGGTTGAGAAAAGTTCAGAGCGCCCACAACCCGGGATAGCACAACAGTGGATCCAGAGTA
AGAGGGAAGCCATTGTGAGCCAGATGACTGAAGCCTGCCTGAACCAATCCCTGGACGCCCTTCT
GTCTCGGGACCTGATCATGAAGGAGGACTATGAACTCATTAGCACCAAACCTACAAGGACCGCA
AAAGTCAGACAGCTGCTAGATACCTCTGACATCCAAGGAGAAGAGTTTGCCAGAGTTATAGTAC
AGAAGTTGAAAGACAACAAGCAGATGGGGCTTCAGCCTTACCCGGAAGTACTTTTGGTTTCCAG
AACACCATCTTCAAATGTCCTTCAAAATAAAACCTTATAAGGGGGCCTTCTTTGAGGGGAAAGT
CGGTTTACAAATGATTATTTATATTTCTGTTACCTGTATAATATTTGTATAAAAACATGAGAGT
ATTAGATGCTTCAGTGAAGGTTTTTGGAAGAGTCTCTTCCCATGACGTTGCAGTATTTTTTTTT
AAATTAATATAAGTAAAAAGTTTGCATTATGCTGTGTAGTTCAGTTTTTATGTCAGCTTCACTA
CTTGAACTTTTTTTTAATGTGATAATCACATTTTTCTTATATGTAACAAGCCTTCGTTTCTGAT
GGAAGACATTTTCCCACTCACCTGACCTGTGGATTCCTCATTATTCCTCTAAAGTGCGGTTTGA
CATTACATAGCAGTGATATGGTGTTGCCCCTCTGCAACCCCAAGTTCAGATCTCCAGAGAGTTA
CTCATTTTTAAATTTGATTTACAAATTCTTTAGAAGGTGGTTTCAAGGAATACAAAGTGTATAA
AGAAGAAAAAAAAGAGAGAGAGAGAGAATCTTTTACTAACACTGGCCGTCCGTGTACCTCTGCT
TGACCTTTGCCTCCTGTCTTTCTCCAGAGCAAGCAGCCCATTGTGTATCCTGCTGCAGCCTGCT
TCCGGCTCCTATTTTAAGAATATGCTGGTTGGGTAGAGGCCGGCCTTTGCTTCGCTATTTCCTT
TGTAACACACCATGGTTTTTGAACTGAAGGGTACATCCGGTGTCTCCCCCAGCTCACCTAACTA
ACTCCGTTCAATTACCGCACAGCGGCCATGCCTCTCTGTGTTTGCTTTTCCAAGCGTGTTCTCA
ACTTCACGACAAACAATAAAAAGGCAATACAGTGTGCGTTCCTTTTATCTTTTGGTTCTTAGCT
TATGTCGGTAAAGGTAACCTTTTTTCTGAAAACTGTTGACCAAAGTTAGACGTGAGAAATGGTA
TGAATTTGAAAGTTCAAACTTGTAGGAAGCGCCTGACTTGTAACTTAAAACAGTATGAATACGG
GATAAAAGGACTTAGGTCAATGAAATATTTCTTAATTTGAAAAAAAGTTTAAACACCAAGGTTG
GAGAGATGGTTCAGTACAGTTCTTAGGAGCACTGGCTGCTCTGTGAGAGGACCCAGGTTCTGTT
CCTAGCACCCACATGATACCTCGCAATCATGAATAACTCCAGTTCCAGGGGATACAGCCCTCTT
CTGGCCTTTACAGGCCACCAGGCAGGTGTGCAGTGCACTTCCACACAGGCAAAACACTCATATG
TATCATATATGTAAGGGGGAATGTTTAAAGAGTTTAAATTCCGTTTTAAAGTAACATTTGCCTG
TGGTATGACTCTTAGGGGACTTTCACAAACACAGAAATTTAAAGAGAAAAATAAAAATCAGACT
CATGAGTTGCTATTGAATTCTTTTAAAAGTGTGAAAATGAAAACTCAGGTGTGGCAGTACACCT
GTTATCCCAGAACACTGGAAATGGAATCATTCAGATCAAGAGTTCAGAGTCATCCTTAGCTACT
TAATAAGGTCAGAGCAACCCTGGGCCATCTGAGATTCTGTATTCAATAGACTACAAAAGTTTAT
CTTGGGAATTAAAAAAGAAGAAGTATTTTTAA

hide sequence

RefSeq Acc Id:

XM_039110221 ⟹ XP_038966149

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	29,630,806 - 29,657,581 (-)	NCBI

RefSeq Acc Id:

XR_005504472

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	29,635,658 - 29,662,804 (-)	NCBI

RefSeq Acc Id:

XR_005504473

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	29,635,582 - 29,662,803 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001178794	(Get FASTA)	NCBI Sequence Viewer
	XP_017448959	(Get FASTA)	NCBI Sequence Viewer
	XP_038966149	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI07469	(Get FASTA)	NCBI Sequence Viewer
	EDL98485	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000012963
	ENSRNOP00000012963.2

RefSeq Acc Id:

NP_001178794 ⟸ NM_001191865

- UniProtKB:

G3V783 (UniProtKB/TrEMBL), A6IIB5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNGDAICSALPHIPYHKLADLHYLSRGASGTVSSARHADWRVRVAVKHLHIHTPLLDSERNDIL
REAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPEIAWPLRFRILHEI
ALGVNYLHNMNPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSYKSAPEGGTIIY
MPPENYEPGQKSRASVKHDIYSYAVIMWEVLSRKQPFEEVTNPLQIMYSVSQGHRPNTSEENLP
FDIPHRGLMISLIQSGWAQNPDERPSFLKCLIELEPVLRTFEDITFLEAVIQLKKSKIQSASST
IHLCDKKMDLSLNIPASHPPQEESCGSSLLSRNAGSPGTSRSLSAPQDKGFFHGGPQDCSSSKA
YHCPGNHSWDGIISVSQEAAFCDRRASSCSLTVIRPLLVEKSSERPQPGIAQQWIQSKREAIVS
QMTEACLNQSLDALLSRDLIMKEDYELISTKPTRTAKVRQLLDTSDIQGEEFARVIVQKLKDNK
QMGLQPYPEVLLVSRTPSSNVLQNKTL

hide sequence

RefSeq Acc Id:	XP_017448959 ⟸ XM_017593470
- Peptide Label:	isoform X1
- UniProtKB:	Q3B7U0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPNGSLNELLHRKTEYPEIAWPLRFRILHEIALGVNYLHNMNPPLLHHDLKTQNILLDNEFHVK IADFGLSKWRMMSLSQSRSYKSAPEGGTIIYMPPENYEPGQKSRASVKHDIYSYAVIMWEVLSR KQPFEEVTNPLQIMYSVSQGHRPNTSEENLPFDIPHRGLMISLIQSGWAQNPDERPSFLKCLIE LEPVLRTFEDITFLEAVIQLKKSKIQSASSTIHLCDKKMDLSLNIPASHPPQEESCGSSLLSRN AGSPGTSRSLSAPQDKGFFHGGPQDCSSSKAYHCPGNHSWDGIISVSQEAAFCDRRASSCSLTV IRPLLVEKSSERPQPGIAQQWIQSKREAIVSQMTEACLNQSLDALLSRDLIMKEDYELISTKPT RTAKVRQLLDTSDIQGEEFARVIVQKLKDNKQMGLQPYPEVLLVSRTPSSNVLQNKTL hide sequence

RefSeq Acc Id:

ENSRNOP00000012963 ⟸ ENSRNOT00000012963

RefSeq Acc Id:	XP_038966149 ⟸ XM_039110221
- Peptide Label:	isoform X2
- UniProtKB:	Q3B7U0 (UniProtKB/TrEMBL)

Protein Domains

CARD Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V783-F1-model_v2	AlphaFold	G3V783	1-539	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693582

Promoter ID:

EPDNEW_R4107

Type:

initiation region

Name:

Ripk2_1

Description:

receptor-interacting serine-threonine kinase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	29,870,383 - 29,870,443	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309167	AgrOrtholog
BioCyc Gene	G2FUF-41857	BioCyc
Ensembl Genes	ENSRNOG00000009389	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000012963	ENTREZGENE
	ENSRNOT00000012963.6	UniProtKB/TrEMBL
Gene3D-CATH	1.10.533.10	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7458993	IMAGE-MGC_LOAD
InterPro	CARD	UniProtKB/TrEMBL
	CARD_RIP2	UniProtKB/TrEMBL
	DEATH-like	UniProtKB/TrEMBL
	Kinase-like_dom	UniProtKB/TrEMBL
	Prot_kinase_cat_dom	UniProtKB/TrEMBL
	Rcpt-int_Ser/Thr_kinase-2	UniProtKB/TrEMBL
	Ser-Thr/Tyr_kinase_cat_dom	UniProtKB/TrEMBL
	Ser/Thr_kinase_AS	UniProtKB/TrEMBL
	Tyr_kinase_cat_dom	UniProtKB/TrEMBL
KEGG Report	rno:362491	UniProtKB/TrEMBL
MGC_CLONE	MGC:125253	IMAGE-MGC_LOAD
NCBI Gene	362491	ENTREZGENE
PANTHER	RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2	UniProtKB/TrEMBL
	SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED	UniProtKB/TrEMBL
Pfam	CARD	UniProtKB/TrEMBL
	Pkinase_Tyr	UniProtKB/TrEMBL
PhenoGen	Ripk2	PhenoGen
PIRSF	STPK_RIP2	UniProtKB/TrEMBL
PROSITE	CARD	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000009389	RatGTEx
SMART	S_TKc	UniProtKB/TrEMBL
	TyrKc	UniProtKB/TrEMBL
Superfamily-SCOP	DEATH_like	UniProtKB/TrEMBL
	Kinase_like	UniProtKB/TrEMBL
UniProt	A6IIB5	ENTREZGENE, UniProtKB/TrEMBL
	G3V783	ENTREZGENE, UniProtKB/TrEMBL
	Q3B7U0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-09-09	Ripk2	receptor-interacting serine-threonine kinase 2	Ripk2	receptor (TNFRSF)-interacting serine-threonine kinase 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Ripk2	receptor (TNFRSF)-interacting serine-threonine kinase 2	Ripk2_predicted	receptor (TNFRSF)-interacting serine-threonine kinase 2 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Ripk2_predicted	receptor (TNFRSF)-interacting serine-threonine kinase 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)