Prim1 (DNA primase subunit 1) - Rat Genome Database

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Gene: Prim1 (DNA primase subunit 1) Rattus norvegicus
Analyze
Symbol: Prim1
Name: DNA primase subunit 1
RGD ID: 621380
Description: Predicted to enable DNA primase activity; metal ion binding activity; and ribonucleotide binding activity. Predicted to be involved in DNA replication initiation and DNA replication, synthesis of RNA primer. Predicted to be part of alpha DNA polymerase:primase complex. Orthologous to human PRIM1 (DNA primase subunit 1); PARTICIPATES IN DNA replication pathway; purine metabolic pathway; pyrimidine metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA primase small subunit; DNA primase small subunit, 49kDa; DNA primase, p49 subunit; MGC109113; primase (DNA) subunit 1; primase, DNA, polypeptide 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27446,342 - 462,526 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7431,805 - 462,526 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx73,205,126 - 3,220,740 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.075,081,138 - 5,096,753 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.075,379,312 - 5,394,371 (+)NCBIRnor_WKY
Rnor_6.072,435,524 - 2,451,169 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,435,553 - 2,451,165 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,415,106 - 2,430,940 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,293,137 - 1,323,029 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.171,293,147 - 1,321,776 (+)NCBI
Celera7325,353 - 341,972 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
coumestrol  (ISO)
cyclosporin A  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
Enterolactone  (ISO)
ethanol  (EXP)
flutamide  (EXP)
folic acid  (ISO)
genistein  (ISO)
kojic acid  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
lucanthone  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phytoestrogen  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression, purification, and characterization of the two human primase subunits and truncated complexes from Escherichia coli. Copeland WC Protein Expr Purif 1997 Feb;9(1):1-9.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. A mutation in subunit B of the DNA polymerase alpha-primase complex from Novikoff hepatoma cells concomitant with a conformational change and abnormal catalytic properties of the DNA polymerase alpha-primase complex. Popanda O, etal., Mol Carcinog 2001 Aug;31(4):171-83.
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:19946888  


Genomics

Comparative Map Data
Prim1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27446,342 - 462,526 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7431,805 - 462,526 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx73,205,126 - 3,220,740 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.075,081,138 - 5,096,753 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.075,379,312 - 5,394,371 (+)NCBIRnor_WKY
Rnor_6.072,435,524 - 2,451,169 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,435,553 - 2,451,165 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,415,106 - 2,430,940 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,293,137 - 1,323,029 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.171,293,147 - 1,321,776 (+)NCBI
Celera7325,353 - 341,972 (+)NCBICelera
Cytogenetic Map7q11NCBI
PRIM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381256,731,580 - 56,752,323 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1256,731,296 - 56,752,374 (-)EnsemblGRCh38hg38GRCh38
GRCh371257,125,364 - 57,146,107 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,411,631 - 55,432,413 (-)NCBINCBI36Build 36hg18NCBI36
Build 341255,411,632 - 55,432,413NCBI
Celera1256,779,329 - 56,800,102 (-)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1254,164,017 - 54,185,223 (-)NCBIHuRef
CHM1_11257,092,951 - 57,113,728 (-)NCBICHM1_1
T2T-CHM13v2.01256,699,510 - 56,720,267 (-)NCBIT2T-CHM13v2.0
Prim1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910127,851,084 - 127,865,899 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10127,851,037 - 127,865,906 (+)EnsemblGRCm39 Ensembl
GRCm3810128,015,215 - 128,030,030 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,015,168 - 128,030,037 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710127,452,271 - 127,467,086 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610127,418,164 - 127,432,979 (+)NCBIMGSCv36mm8
Celera10130,410,422 - 130,425,144 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1076.39NCBI
Prim1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554584,275,517 - 4,294,257 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554584,265,500 - 4,294,329 (-)NCBIChiLan1.0ChiLan1.0
PRIM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11232,408,929 - 32,428,734 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1232,408,929 - 32,428,734 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01232,155,541 - 32,176,363 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PRIM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110951,888 - 975,966 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha101,016,706 - 1,040,803 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.010963,062 - 987,154 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10963,379 - 987,127 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110940,115 - 964,262 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0101,182,031 - 1,206,116 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0101,306,679 - 1,330,830 (-)NCBIUU_Cfam_GSD_1.0
Prim1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494557,815,995 - 57,836,332 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366461,036,777 - 1,054,108 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366461,033,921 - 1,054,203 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRIM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl522,062,989 - 22,089,436 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1522,064,248 - 22,089,441 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2523,800,887 - 23,824,231 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRIM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11152,676,890 - 52,699,337 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037193,277,385 - 193,299,812 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prim1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480211,289,391 - 11,316,958 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480211,288,654 - 11,312,401 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prim1
123 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:49
Count of miRNA genes:47
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000065593
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 29 53 37 19 37 1 1 74 33 40 11 1
Low 14 4 4 4 7 10 2 1 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000065593   ⟹   ENSRNOP00000062827
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7431,805 - 462,526 (+)Ensembl
Rnor_6.0 Ensembl72,435,553 - 2,451,165 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100470   ⟹   ENSRNOP00000094606
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7438,080 - 462,526 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114099   ⟹   ENSRNOP00000087447
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7446,361 - 450,546 (+)Ensembl
RefSeq Acc Id: NM_001008768   ⟹   NP_001008768
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27446,373 - 462,516 (+)NCBI
Rnor_6.072,435,524 - 2,451,169 (+)NCBI
Rnor_5.072,415,106 - 2,430,940 (+)NCBI
RGSC_v3.471,293,137 - 1,323,029 (+)RGD
Celera7325,353 - 341,972 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001304365   ⟹   NP_001291294
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27446,373 - 462,516 (+)NCBI
Rnor_6.072,435,524 - 2,451,169 (+)NCBI
Celera7325,353 - 341,972 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039078421   ⟹   XP_038934349
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27446,342 - 461,276 (+)NCBI
RefSeq Acc Id: XM_039078422   ⟹   XP_038934350
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27446,343 - 462,526 (+)NCBI
RefSeq Acc Id: XM_039078423   ⟹   XP_038934351
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27446,381 - 462,516 (+)NCBI
RefSeq Acc Id: XM_039078424   ⟹   XP_038934352
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27447,149 - 462,526 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001008768   ⟸   NM_001008768
- Peptide Label: isoform 2
- Sequence:
RefSeq Acc Id: NP_001291294   ⟸   NM_001304365
- Peptide Label: isoform 1
- Sequence:
RefSeq Acc Id: ENSRNOP00000062827   ⟸   ENSRNOT00000065593
RefSeq Acc Id: XP_038934349   ⟸   XM_039078421
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038934350   ⟸   XM_039078422
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038934351   ⟸   XM_039078423
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038934352   ⟸   XM_039078424
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000087447   ⟸   ENSRNOT00000114099
RefSeq Acc Id: ENSRNOP00000094606   ⟸   ENSRNOT00000100470

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LNK6-F1-model_v2 AlphaFold F1LNK6 1-297 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694919
Promoter ID:EPDNEW_R5444
Type:initiation region
Name:Prim1_1
Description:DNA primase subunit 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.072,435,543 - 2,435,603EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621380 AgrOrtholog
BioCyc Gene G2FUF-35402 BioCyc
Ensembl Genes ENSRNOG00000031993 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000062827.4 UniProtKB/TrEMBL
  ENSRNOP00000087447.1 UniProtKB/TrEMBL
  ENSRNOP00000094606.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065593.4 UniProtKB/TrEMBL
  ENSRNOT00000100470.1 UniProtKB/TrEMBL
  ENSRNOT00000114099.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7379940 IMAGE-MGC_LOAD
InterPro DNA_primase_S UniProtKB/TrEMBL
  DNA_primase_ssu_euk/arc UniProtKB/TrEMBL
MGC_CLONE MGC:109113 IMAGE-MGC_LOAD
NCBI Gene 246327 ENTREZGENE
PANTHER DNA_primase_S_euk_arch UniProtKB/TrEMBL
Pfam DNA_primase_S UniProtKB/TrEMBL
PhenoGen Prim1 PhenoGen
TIGRFAMs primase_sml UniProtKB/TrEMBL
UniProt A0A8I6A791_RAT UniProtKB/TrEMBL
  A0A8I6AML7_RAT UniProtKB/TrEMBL
  F1LNK6_RAT UniProtKB/TrEMBL
  Q5M832_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-22 Prim1  DNA primase subunit 1  Prim1  primase (DNA) subunit 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-01-03 Prim1  primase (DNA) subunit 1  Prim1  primase, DNA, polypeptide 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-14 Prim1  primase, DNA, polypeptide 1  Prim1  DNA primase, p49 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-08-07 Prim1  DNA primase, p49 subunit      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_drugs mutation in position 862 (GTG-->ATG) that caused a change of valine to methionine in codon 288 results in higher sensitivity to camptothecin, topotecan, and structurally related compounds in highly malignant Novikoff hepatoma cells 633584