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Gene: Pdx1 (pancreatic and duodenal homeobox 1) Rattus norvegicus
Symbol: Pdx1
Name: pancreatic and duodenal homeobox 1
RGD ID: 62387
Description: Exhibits several functions, including DNA-binding transcription factor activity; promoter-specific chromatin binding activity; and sequence-specific DNA binding activity. Contributes to DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including animal organ development; detection of glucose; and regulation of transcription, DNA-templated. Localizes to cytoplasm and nucleus. Biomarker of hyperglycemia; placental insufficiency; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in cerebral infarction; hyperglycemia; maturity-onset diabetes of the young type 4; pancreatic agenesis; and type 2 diabetes mellitus. Orthologous to human PDX1 (pancreatic and duodenal homeobox 1); PARTICIPATES IN forkhead class A signaling pathway; maturity-onset diabetes of the young pathway; type 2 diabetes mellitus pathway; INTERACTS WITH 17beta-estradiol; 3-aminobenzamide; 9-cis-retinoic acid.
Type: protein-coding
Also known as: IDX-1; Idx1; Insulin promoter factor 1; insulin promotor factor 1; IPF-1; Ipf1; islet/duodenum homeobox 1; islet/duodenum homeobox-1; pancreas/duodenum homeobox protein 1; pancreatic and duodenal homeobox gene 1; somatostatin transactivating factor 1; somatostatin-transactivating factor 1; STF-1; Stf1
Homo sapiens (human) : PDX1 (pancreatic and duodenal homeobox 1)  HGNC  Alliance
Mus musculus (house mouse) : Pdx1 (pancreatic and duodenal homeobox 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pdx1 (pancreatic and duodenal homeobox 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PDX1 (pancreatic and duodenal homeobox 1)
Canis lupus familiaris (dog) : PDX1 (pancreatic and duodenal homeobox 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pdx1 (pancreatic and duodenal homeobox 1)
Sus scrofa (pig) : PDX1 (pancreatic and duodenal homeobox 1)
Chlorocebus sabaeus (African green monkey) : PDX1 (pancreatic and duodenal homeobox 1)
Heterocephalus glaber (naked mole-rat) : Pdx1 (pancreatic and duodenal homeobox 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0129,496,044 - 9,501,211 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl129,496,044 - 9,501,213 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01211,609,488 - 11,614,655 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera129,495,501 - 9,500,668 (-)NCBICelera
Cytogenetic Map12p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Pdx1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 62387
Created: 2001-04-26
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.