Pdx1 (pancreatic and duodenal homeobox 1) - Rat Genome Database

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Gene: Pdx1 (pancreatic and duodenal homeobox 1) Rattus norvegicus
Analyze
Symbol: Pdx1
Name: pancreatic and duodenal homeobox 1
RGD ID: 62387
Description: Exhibits several functions, including DNA-binding transcription factor activity; promoter-specific chromatin binding activity; and sequence-specific DNA binding activity. Contributes to DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including animal organ development; detection of glucose; and regulation of transcription, DNA-templated. Localizes to cytoplasm and nucleus. Biomarker of hyperglycemia; placental insufficiency; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in cerebral infarction; hyperglycemia; maturity-onset diabetes of the young type 4; pancreatic agenesis; and type 2 diabetes mellitus. Orthologous to human PDX1 (pancreatic and duodenal homeobox 1); PARTICIPATES IN forkhead class A signaling pathway; maturity-onset diabetes of the young pathway; type 2 diabetes mellitus pathway; INTERACTS WITH 17beta-estradiol; 3-aminobenzamide; 9-cis-retinoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: IDX-1; Idx1; Insulin promoter factor 1; insulin promotor factor 1; IPF-1; Ipf1; islet/duodenum homeobox 1; islet/duodenum homeobox-1; pancreas/duodenum homeobox protein 1; pancreatic and duodenal homeobox gene 1; somatostatin transactivating factor 1; somatostatin-transactivating factor 1; STF-1; Stf1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2127,757,865 - 7,763,064 (-)NCBI
Rnor_6.0 Ensembl129,496,044 - 9,501,213 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0129,496,044 - 9,501,211 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01211,609,488 - 11,614,655 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera129,495,501 - 9,500,668 (-)NCBICelera
Cytogenetic Map12p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (IEP)
animal organ senescence  (IEP)
cell differentiation  (IMP,ISO)
central nervous system development  (IEP)
detection of glucose  (IDA)
digestive tract development  (ISO)
endocrine pancreas development  (ISO)
exocrine pancreas development  (ISO)
glucose homeostasis  (IMP,ISO)
glucose metabolic process  (ISO)
insulin secretion  (ISO)
liver development  (ISO)
morphogenesis of embryonic epithelium  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription, DNA-templated  (IMP)
negative regulation of type B pancreatic cell apoptotic process  (ISO)
nitric oxide mediated signal transduction  (ISO)
pancreas development  (IEP,ISO)
positive regulation of cell death  (IMP)
positive regulation of cell population proliferation  (IMP,ISO)
positive regulation of DNA binding  (IMP)
positive regulation of insulin secretion  (IMP)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IMP,ISO)
positive regulation of transcription, DNA-templated  (IMP,ISO)
regulation of cell population proliferation  (ISO)
regulation of gene expression  (IMP)
regulation of transcription by RNA polymerase II  (IBA,ISO)
regulation of transcription, DNA-templated  (TAS)
response to alkaloid  (IEP)
response to chlorate  (IEP)
response to cytokine  (IEP)
response to drug  (IEP)
response to fatty acid  (IEP)
response to glucocorticoid  (IEP)
response to glucose  (IEP,IMP)
response to iron(II) ion  (IEP)
response to leucine  (IEP)
response to lipid  (IEP)
response to nicotine  (IEP)
response to nutrient levels  (IEP)
response to organic cyclic compound  (IEP)
response to vitamin  (IEP)
response to wounding  (IEP)
smoothened signaling pathway  (IMP)
stem cell differentiation  (IEP,IMP)
transcription by RNA polymerase II  (IMP)
transcription, DNA-templated  (IMP)
transdifferentiation  (IEP)
type B pancreatic cell differentiation  (IBA,IMP,ISO)

Cellular Component
cytoplasm  (IDA)
cytosol  (IEA)
nuclear speck  (ISO)
nucleoplasm  (ISO)
nucleus  (IBA,IDA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Ahlgren U, etal., Genes Dev. 1998 Jun 15;12(12):1763-8.
2. Andersen FG, etal., FEBS Lett. 1999 Feb 26;445(2-3):315-20.
3. Arantes VC, etal., Br J Nutr. 2006 Dec;96(6):1006-12.
4. Buffat C, etal., J Pathol. 2007 Nov;213(3):337-46.
5. Cao LZ, etal., Diabetes. 2004 Dec;53(12):3168-78.
6. Cardozo AK, etal., J Biol Chem 2001 Dec 28;276(52):48879-86.
7. Chen S, etal., Gene Ther. 2007 Jul;14(14):1102-10. Epub 2007 Apr 26.
8. Chin-Chance CV, etal., J Investig Med. 2006 Apr;54(3):132-42.
9. da Silva Xavier G, etal., Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8319-24. Epub 2004 May 17.
10. Del Guerra S, etal., Diabetes. 2005 Mar;54(3):727-35.
11. Dumortier O, etal., Diabetologia. 2007 Dec;50(12):2495-503. Epub 2007 Sep 19.
12. Dutta S, etal., Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1065-70. Epub 2001 Jan 16.
13. Feanny MA, etal., J Surg Res. 2008 Jan;144(1):8-16. Epub 2007 Jun 20.
14. Ferber S, etal., Nat Med. 2000 May;6(5):568-72.
15. Fodor A, etal., Diabetologia. 2007 Jan;50(1):121-30. Epub 2006 Nov 28.
16. Fujita Y, etal., Am J Physiol Endocrinol Metab. 2008 Sep;295(3):E648-57. Epub 2008 Jul 1.
17. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
18. Gauthier BR, etal., J Biol Chem. 2004 Jul 23;279(30):31121-30. Epub 2004 May 19.
19. Gefen-Halevi S, etal., Cell Reprogram. 2010 Dec;12(6):655-64. doi: 10.1089/cell.2010.0030.
20. Gesina E, etal., Diabetes. 2004 Sep;53(9):2322-9.
21. GOA data from the GO Consortium
22. Hagman DK, etal., Diabetes. 2008 Feb;57(2):424-31. Epub 2007 Nov 8.
23. Hani EH, etal., J Clin Invest. 1999 Nov;104(9):R41-8.
24. Harmon JS, etal., Diabetes. 1999 Oct;48(10):1995-2000.
25. Hoffman BG, etal., BMC Dev Biol. 2008 Sep 8;8:81.
26. Ihm SH, etal., Diabetes Res Clin Pract. 2007 Sep;77 Suppl 1:S150-4. Epub 2007 Apr 30.
27. Ishikawa M, etal., J Lipid Res. 2008 Dec;49(12):2524-34. Epub 2008 Aug 5.
28. Jetton TL, etal., Am J Physiol Endocrinol Metab. 2008 Apr;294(4):E679-87. Epub 2008 Jan 29.
29. Jetton TL, etal., Diabetes. 2005 Aug;54(8):2294-304.
30. Kerckaert JP, etal., Biochim Biophys Acta 1977 Aug 23;493(2):293-303.
31. Kojima H, etal., Diabetes 2002 May;51(5):1398-408.
32. Kojima I and Umezawa K, Int J Biochem Cell Biol. 2006;38(5-6):923-30. Epub 2005 Oct 26.
33. Krishnamurthy M, etal., Endocrinology. 2007 Nov;148(11):5520-30. Epub 2007 Aug 2.
34. Kwon DY, etal., Eur J Nutr. 2007 Feb;46(1):44-52. Epub 2007 Jan 2.
35. Laybutt DR, etal., Diabetologia. 2007 Oct;50(10):2117-25. Epub 2007 Jul 20.
36. Laybutt DR, etal., J Biol Chem. 2003 Jan 31;278(5):2997-3005. Epub 2002 Nov 15.
37. Leonard J, etal., Mol Endocrinol 1993 Oct;7(10):1275-83.
38. Li H, etal., J Biomed Sci. 2008 Jul;15(4):487-97. Epub 2008 Feb 6.
39. Li L, etal., Diabetes 2004 Mar;53(3):608-15.
40. Li L, etal., Stem Cells Dev. 2008 Aug;17(4):815-23.
41. Li Y, etal., J Cell Physiol. 2007 Apr;211(1):36-44.
42. Lin G, etal., Stem Cells Dev. 2009 Feb 26.
43. Liu T, etal., Hepatobiliary Pancreat Dis Int. 2007 Aug;6(4):424-9.
44. MGD data from the GO Consortium
45. Miller CP, etal., EMBO J 1994 Mar 1;13(5):1145-56.
46. Moibi JA, etal., Diabetes. 2007 Jan;56(1):88-95.
47. Moritoh Y, etal., Br J Pharmacol. 2009 Jun;157(3):415-26. Epub 2009 Apr 3.
48. Muharram G, etal., Biochem Biophys Res Commun. 2005 Aug 12;333(4):1153-9.
49. NCBI rat LocusLink and RefSeq merged data July 26, 2002
50. Nielsen K, etal., Diabetes. 1999 Dec;48(12):2324-32.
51. O'Reilly LA, etal., Diabetes. 1997 Apr;46(4):599-606.
52. Ogata T, etal., Diabetes. 2004 Oct;53(10):2596-602.
53. OMIM Disease Annotation Pipeline
54. Owen KR, etal., Diabetologia. 2004 May;47(5):957-8. Epub 2004 May 7.
55. Park JH, etal., J Clin Invest. 2008 Jun;118(6):2316-24.
56. Park S, etal., J Appl Physiol. 2007 Nov;103(5):1764-71. Epub 2007 Aug 30.
57. Pedersen AA, etal., Biochem Biophys Res Commun 2002 Jul 12;295(2):243-8.
58. Peers B, etal., Mol Cell Biol. 1995 Dec;15(12):7091-7.
59. Perfetti R, etal., Endocrinology. 2000 Dec;141(12):4600-5.
60. Pino MF, etal., Mol Endocrinol. 2005 May;19(5):1343-60. Epub 2005 Jan 13.
61. Pipeline to import KEGG annotations from KEGG into RGD
62. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
63. Qiu Y, etal., Mol Cell Biol. 2002 Jan;22(2):412-20.
64. RGD automated data pipeline
65. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
66. RGD automated import pipeline for gene-chemical interactions
67. Rooman I, etal., Am J Pathol. 2006 Oct;169(4):1206-14.
68. Rooman I, etal., Diabetologia. 2000 Jul;43(7):907-14.
69. Schwartz PT, etal., J Biol Chem. 2000 Jun 23;275(25):19106-14.
70. Shimada K, etal., J Surg Res. 2008 Apr;145(2):229-37. Epub 2007 Aug 30.
71. Shimada K, etal., Transplant Proc. 2008 Mar;40(2):438-40.
72. Shternhall-Ron K, etal., J Autoimmun. 2007 Mar-May;28(2-3):134-42. Epub 2007 Mar 23.
73. Somm E, etal., Endocrinology. 2008 Dec;149(12):6289-99. Epub 2008 Aug 7.
74. Stanojevic V, etal., Endocrinology. 2004 Jun;145(6):2918-28. Epub 2004 Mar 4.
75. Stanojevic V, etal., Mol Cell Endocrinol. 2005 Jun 15;237(1-2):67-74.
76. Stoffers DA, etal., Diabetes. 2003 Mar;52(3):734-40.
77. Sun Y, etal., Endocrinology. 2008 Feb;149(2):662-71. Epub 2007 Nov 8.
78. Taguchi M and Otsuki M, J Mol Histol. 2004 Nov;35(8-9):785-9.
79. Taguchi M, etal., J Pathol. 2002 Aug;197(5):638-46.
80. Tanabe K, etal., PLoS Biol. 2008 Feb;6(2):e37.
81. Thomas MK, etal., Endocrinology. 2001 Mar;142(3):1033-40.
82. Tiemann K, etal., Virchows Arch. 2007 Mar;450(3):261-6. Epub 2007 Jan 18.
83. Ubeda M, etal., J Biol Chem. 2006 Sep 29;281(39):28858-64. Epub 2006 Aug 3.
84. Wang GS, etal., J Autoimmun. 2000 Dec;15(4):407-16.
85. Wang H, etal., J Biol Chem. 2001 Jul 6;276(27):25279-86. Epub 2001 Apr 17.
86. West AR and Oates PS, Am J Physiol Gastrointest Liver Physiol. 2005 Dec;289(6):G1108-14. Epub 2005 Aug 4.
87. Yamada S, etal., Endocr J. 2006 Dec;53(6):789-95. Epub 2006 Sep 19.
88. Yamada Y, etal., Int J Mol Med. 2008 Jun;21(6):801-8.
89. Yang Y, etal., Nucleic Acids Res. 2009 May;37(8):2529-38. Epub 2009 Mar 5.
90. Yoshikawa H, etal., Metabolism. 2002 Feb;51(2):163-8.
91. Zertal-Zidani S, etal., Diabetologia. 2007 Mar;50(3):585-95. Epub 2007 Jan 13.
92. Zhang SS, etal., Proc Natl Acad Sci U S A. 2009 May 5;106(18):7531-6. Epub 2009 Apr 20.
93. Zhang X, etal., J Cell Mol Med. 2009 Apr;13(4):758-70.
94. Zhang YH, etal., Anat Rec (Hoboken). 2009 May;292(5):728-35.
Additional References at PubMed
PMID:8567692   PMID:8625829   PMID:9353644   PMID:10868931   PMID:11287626   PMID:12124776   PMID:12368292   PMID:12488434   PMID:12904469   PMID:12972592   PMID:14701942   PMID:14702043  
PMID:14704343   PMID:15121856   PMID:15486225   PMID:15605246   PMID:15793245   PMID:15888377   PMID:15944145   PMID:16126192   PMID:16166097   PMID:16418487   PMID:16847327   PMID:17056599  
PMID:17172056   PMID:17876894   PMID:17897921   PMID:17928203   PMID:17941991   PMID:18155690   PMID:18670842   PMID:18971862   PMID:19266047   PMID:19513971   PMID:19604517   PMID:19619492  
PMID:19651901   PMID:19656489   PMID:19799567   PMID:19833727   PMID:19837876   PMID:20306305   PMID:20401447   PMID:20458761   PMID:20589757   PMID:20626638   PMID:20644547   PMID:20811152  
PMID:20943817   PMID:21385937   PMID:21533167   PMID:21652712   PMID:22028850   PMID:22086006   PMID:22253604   PMID:22644623   PMID:23123389   PMID:23147208   PMID:23424659   PMID:23703573  
PMID:23853095   PMID:24029239   PMID:24567802   PMID:25667428   PMID:27620967   PMID:27645924   PMID:29303357   PMID:30353648   PMID:30997693   PMID:31337977   PMID:32690606  


Genomics

Comparative Map Data
Pdx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2127,757,865 - 7,763,064 (-)NCBI
Rnor_6.0 Ensembl129,496,044 - 9,501,213 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0129,496,044 - 9,501,211 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01211,609,488 - 11,614,655 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera129,495,501 - 9,500,668 (-)NCBICelera
Cytogenetic Map12p11NCBI
PDX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1327,920,000 - 27,926,313 (+)EnsemblGRCh38hg38GRCh38
GRCh381327,919,982 - 27,926,313 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371328,494,137 - 28,500,450 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361327,392,157 - 27,397,394 (+)NCBINCBI36hg18NCBI36
Build 341327,392,176 - 27,397,394NCBI
Celera139,568,879 - 9,575,162 (+)NCBI
Cytogenetic Map13q12.2NCBI
HuRef139,314,253 - 9,320,535 (+)NCBIHuRef
CHM1_11328,462,445 - 28,468,728 (+)NCBICHM1_1
Pdx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395147,206,907 - 147,212,658 (+)NCBIGRCm39mm39
GRCm39 Ensembl5147,206,769 - 147,212,658 (+)Ensembl
GRCm385147,270,097 - 147,275,848 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5147,269,959 - 147,275,848 (+)EnsemblGRCm38mm10GRCm38
MGSCv375148,081,707 - 148,086,725 (+)NCBIGRCm37mm9NCBIm37
MGSCv365147,580,475 - 147,586,196 (+)NCBImm8
Celera5145,261,170 - 145,266,188 (+)NCBICelera
Cytogenetic Map5G3NCBI
cM Map586.84NCBI
Pdx1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554977,281,886 - 7,307,969 (+)NCBIChiLan1.0ChiLan1.0
PDX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11327,545,855 - 27,553,118 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0139,199,572 - 9,206,202 (+)NCBIMhudiblu_PPA_v0panPan3
PDX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12511,741,863 - 11,746,885 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2511,741,863 - 11,746,885 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2511,805,337 - 11,810,359 (-)NCBI
ROS_Cfam_1.02511,870,873 - 11,875,895 (-)NCBI
UMICH_Zoey_3.12511,765,554 - 11,770,575 (-)NCBI
UNSW_CanFamBas_1.02511,758,195 - 11,763,217 (-)NCBI
UU_Cfam_GSD_1.02511,802,135 - 11,807,157 (-)NCBI
Pdx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945172,845,028 - 172,849,677 (-)NCBI
SpeTri2.0NW_00493647223,102,534 - 23,107,127 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl115,303,639 - 5,310,843 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1115,303,609 - 5,309,063 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2114,961,177 - 4,966,632 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.137,038,088 - 7,046,593 (+)NCBI
ChlSab1.1 Ensembl37,041,466 - 7,045,976 (+)Ensembl
Vero_WHO_p1.0NW_02366605737,343,264 - 37,348,413 (-)NCBI
Pdx1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477610,591,855 - 10,596,738 (-)NCBI

Position Markers
RH94684  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2127,758,030 - 7,758,204 (+)MAPPER
Rnor_6.0129,496,210 - 9,496,383NCBIRnor6.0
Rnor_5.01211,609,654 - 11,609,827UniSTSRnor5.0
Celera129,495,667 - 9,495,840UniSTS
RH94789  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2127,757,867 - 7,758,036 (+)MAPPER
Rnor_6.0129,496,047 - 9,496,215NCBIRnor6.0
Rnor_5.01211,609,491 - 11,609,659UniSTSRnor5.0
Celera129,495,504 - 9,495,672UniSTS
Pdx1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2127,758,255 - 7,758,564 (+)MAPPER
Rnor_6.0129,496,435 - 9,496,743NCBIRnor6.0
Rnor_5.01211,609,879 - 11,610,187UniSTSRnor5.0
Celera129,495,892 - 9,496,200UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12111765163Rat
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12122650917Rat
10450854Stl34Serum triglyceride level QTL 343.50.05blood LDL triglyceride amount (VT:0010699)blood lipoprotein triglyceride level (CMO:0002685)12122853017Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12123035872Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123758197Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12130749723Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12136919844Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12138334225Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)1215081045150810Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1215081045150810Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)1215081045150810Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1215081045150810Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1215081045150810Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1215081045150810Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)1215081045150810Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)1249257845492578Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12125813910257059Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12247568747475687Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12251344247513442Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12251344247513442Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12421005149210051Rat
724526Uae3Urinary albumin excretion QTL 34.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)12540609412355490Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12824960820590080Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12895459327911196Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6922362652716770Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12922362652716770Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12922362652716770Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12922362652716770Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12922362652716770Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12922362652716770Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12922363052716770Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:210
Count of miRNA genes:149
Interacting mature miRNAs:156
Transcripts:ENSRNOT00000071942
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hemolymphoid system hepatobiliary system renal system reproductive system
High
Medium
Low 4 4 4
Below cutoff 2 7 5 6 5 2 10

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000071942   ⟹   ENSRNOP00000066935
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl129,496,044 - 9,501,213 (-)Ensembl
RefSeq Acc Id: NM_022852   ⟹   NP_074043
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2127,757,865 - 7,763,064 (-)NCBI
Rnor_6.0129,496,044 - 9,501,211 (-)NCBI
Rnor_5.01211,609,488 - 11,614,655 (-)NCBI
Celera129,495,501 - 9,500,668 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_074043 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA18355 (Get FASTA)   NCBI Sequence Viewer  
  EDL89565 (Get FASTA)   NCBI Sequence Viewer  
  P52947 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_074043   ⟸   NM_022852
- Sequence:
RefSeq Acc Id: ENSRNOP00000066935   ⟸   ENSRNOT00000071942

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62387 AgrOrtholog
Ensembl Genes ENSRNOG00000046458 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000066935 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000071942 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot
  Homeobox_antennapedia UniProtKB/Swiss-Prot
  Homeobox_CS UniProtKB/Swiss-Prot
  Homeobox_dom UniProtKB/Swiss-Prot
  Homeobox_metazoa UniProtKB/Swiss-Prot
KEGG Report rno:29535 UniProtKB/Swiss-Prot
NCBI Gene 29535 ENTREZGENE
Pfam Homeodomain UniProtKB/Swiss-Prot
PhenoGen Pdx1 PhenoGen
PRINTS ANTENNAPEDIA UniProtKB/Swiss-Prot
  HOMEOBOX UniProtKB/Swiss-Prot
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot
  HOMEOBOX_2 UniProtKB/Swiss-Prot
SMART HOX UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot
UniProt P52947 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-18 Pdx1  pancreatic and duodenal homeobox 1  Pdx1  pancreatic and duodenal homeobox gene 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Pdx1  pancreatic and duodenal homeobox gene 1      Symbol and Name status set to approved 70586 APPROVED
2001-06-12 Ipf1  Insulin promoter factor 1      Symbol withdrawn, duplicate entry of Pdx1(RGD:62387) 62408 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_process involved in maintenance of differentiated beta-cell functions 70227
gene_regulation activity inhibited by cytokines such as interteukine1-beta and interferon-gamma, inhibitory effect prevented by blocking NF-kappaB activation or NO production 70227
gene_regulation inhibitory effect can be prevented by blocking NF-kappaB activation or NO production 70227