Gbp1-ps1 (guanylate binding protein 1, pseudogene 1) - Rat Genome Database

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Gene: Gbp1-ps1 (guanylate binding protein 1, pseudogene 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Gbp1-ps1
Name: guanylate binding protein 1, pseudogene 1
RGD ID: 1560801
Description: Orthologous to several human genes including GBP1 (guanylate binding protein 1); INTERACTS WITH metformin; phenformin; rotenone.
Type: pseudo (Ensembl: protein-coding)
RefSeq Status: MODEL
Previously known as: guanylate-binding protein 1-like; LOC288456; RGD1560801; similar to guanylate binding protein 1, interferon-inducible, 67kDa
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Related Functional Gene: Gbp1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82234,190,708 - 234,199,103 (+)NCBIGRCr8
mRatBN7.22231,517,485 - 231,525,865 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2231,517,398 - 231,529,600 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.02248,533,339 - 248,561,766 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02267,050,086 - 267,086,756 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42240,614,210 - 240,630,078 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2223,554,104 - 223,591,537 (+)NCBICelera
Cytogenetic Map2q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
metformin  (EXP)
phenformin  (EXP)
rotenone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.

Genomics

Variants

.
Variants in Gbp1-ps1
94 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2229059610249053267Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2218414747240841241Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
8693697Alc36Alcohol consumption QTL 3620.592drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2217139753236660713Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2215377404237938339Rat
8693622Alc26Alcohol consumption QTL 262.40.667drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2221136523241305619Rat
7411555Bw132Body weight QTL 1320.001body mass (VT:0001259)body weight gain (CMO:0000420)2223389739249053267Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
9587428Epfw6Epididymal fat weight QTL 67.470.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)2223389739249053267Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000045855   ⟹   ENSRNOP00000046300
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2231,517,398 - 231,529,600 (+)Ensembl
RefSeq Acc Id: XR_005500420
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82234,190,708 - 234,199,103 (+)NCBI
mRatBN7.22231,517,485 - 231,525,865 (+)NCBI
Protein Sequences
Ensembl Protein ENSRNOP00000046300.5
Ensembl Acc Id: ENSRNOP00000046300   ⟸   ENSRNOT00000045855
Protein Domains
GB1/RHD3-type G

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZKU6-F1-model_v2 AlphaFold D3ZKU6 1-593 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560801 AgrOrtholog
BioCyc Gene G2FUF-50990 BioCyc
Ensembl Genes ENSRNOG00000023943 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000045855.5 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
  Guanylate-binding protein, C-terminal domain UniProtKB/TrEMBL
InterPro G_GB1_RHD3_dom UniProtKB/TrEMBL
  GBP_C UniProtKB/TrEMBL
  Guanylate-bd/ATL_C UniProtKB/TrEMBL
  Guanylate-bd_C_sf UniProtKB/TrEMBL
  Guanylate-bd_N UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene 288456 ENTREZGENE
PANTHER GUANYLATE BINDING PROTEIN UniProtKB/TrEMBL
  GUANYLATE-BINDING PROTEIN 2 UniProtKB/TrEMBL
Pfam GBP UniProtKB/TrEMBL
  GBP_C UniProtKB/TrEMBL
PhenoGen Gbp1-ps1 PhenoGen
PROSITE G_GB1_RHD3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000023943 RatGTEx
Superfamily-SCOP SSF48340 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt D3ZKU6_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-10 Gbp1-ps1  guanylate binding protein 1, pseudogene 1  RGD1560801  similar to guanylate binding protein 1, interferon-inducible, 67kDa  Symbol and Name Changed 1299863 APPROVED
2008-04-30 RGD1560801  similar to guanylate binding protein 1, interferon-inducible, 67kDa   RGD1560801_predicted  similar to guanylate binding protein 1, interferon-inducible, 67kDa (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1560801_predicted  similar to guanylate binding protein 1, interferon-inducible, 67kDa (predicted)  LOC288456  similar to guanylate binding protein 1, interferon-inducible, 67kDa  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC288456  similar to guanylate binding protein 1, interferon-inducible, 67kDa      Symbol and Name status set to provisional 70820 PROVISIONAL