Gene: Tfe3 (transcription factor binding to IGHM enhancer 3) Rattus norvegicus
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Symbol:
Tfe3
Name:
transcription factor binding to IGHM enhancer 3
Description:
Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II proximal promoter sequence-specific DNA binding activity; and protein heterodimerization activity. Predicted to be involved in several processes, including negative regulation of cold-induced thermogenesis; positive regulation of transcription by RNA polymerase II; and regulation of osteoclast differentiation. Predicted to localize to the cytosol and nucleoplasm. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human TFE3 (transcription factor binding to IGHM enhancer 3); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
LOC317376; RGD1559642; similar to Tcfe3 protein; Tcfe3; transcription factor E3
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
TFE3 (transcription factor binding to IGHM enhancer 3) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):
Tfe3 (transcription factor E3) HGNC
Treefam, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Tfe3 (transcription factor binding to IGHM enhancer 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
TFE3 (transcription factor binding to IGHM enhancer 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
TFE3 (transcription factor binding to IGHM enhancer 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Tfe3 (transcription factor binding to IGHM enhancer 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
TFE3 (transcription factor binding to IGHM enhancer 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
MITF (melanocyte inducing transcription factor) HGNC
OrthoDB
Alliance orthologs 3
Homo sapiens (human):
TFE3 (transcription factor binding to IGHM enhancer 3)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Tfe3 (transcription factor E3)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
tfe3a (transcription factor binding to IGHM enhancer 3a)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER, PhylomeDB)
Danio rerio (zebrafish):
tfe3b (transcription factor binding to IGHM enhancer 3b)
Alliance
DIOPT (Ensembl Compara, InParanoid, PANTHER, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):
hlh-30
Alliance
DIOPT (Ensembl Compara, InParanoid, OrthoInspector, PANTHER)
Drosophila melanogaster (fruit fly):
Mitf
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 X 15,574,579 - 15,587,826 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl X 15,575,934 - 15,587,419 (-) Ensembl Rnor_5.0 X 16,355,812 - 16,369,002 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 X 26,768,875 - 26,781,006 (-) NCBI RGSC3.4 rn4 RGSC3.4 Celera X 14,814,215 - 14,827,305 (-) NCBI Celera Cytogenetic Map X q12 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
autistic disorder ISO RGD:1351703 8554872 ClinVar Annotator: match by term: Autistic disorder of childhood onset ClinVar PMID:21681106 , PMID:30208311 congenital disorder of glycosylation type IIm ISO RGD:1351703 8554872 ClinVar Annotator: match by term: CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIm ClinVar PMID:28492532 syndromic X-linked intellectual disability Lubs type ISO RGD:1351703 8554872 ClinVar Annotator: match by term: MECP2 duplication syndrome ClinVar PMID:25741868
Imported Annotations - CTD
renal cell carcinoma ISO RGD:1351703 11554173 CTD Direct Evidence: marker/mechanism CTD Imported Annotations - OMIM
Renal Cell Carcinoma, Xp11-Associated ISO RGD:1351703 7240710 OMIM
(+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of TFE3 mRNA] CTD PMID:31150632 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1557519 6480464 Tetrachlorodibenzodioxin results in decreased expression of TFE3 mRNA CTD PMID:24058054 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1557519 6480464 Tetrachlorodibenzodioxin affects the expression of TFE3 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of TFE3 mRNA CTD PMID:22298810 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:1351703 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TFE3 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TFE3 mRNA CTD PMID:28628672 5-azacytidine increases expression ISO RGD:1351703 6480464 Azacitidine results in increased expression of TFE3 mRNA CTD PMID:19194470 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of TFE3 mRNA CTD PMID:22504374 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of TFE3 mRNA CTD PMID:24780913 acetylsalicylic acid decreases expression ISO RGD:1351703 6480464 Aspirin results in decreased expression of TFE3 mRNA CTD PMID:15928584 aflatoxin B1 decreases methylation ISO RGD:1351703 6480464 Aflatoxin B1 results in decreased methylation of TFE3 gene CTD PMID:27153756 aflatoxin B1 affects methylation ISO RGD:1351703 6480464 Aflatoxin B1 affects the methylation of TFE3 intron CTD PMID:30157460 azathioprine increases expression ISO RGD:1351703 6480464 Azathioprine results in increased expression of TFE3 mRNA CTD PMID:22623647 benzo[a]pyrene increases expression ISO RGD:1557519 6480464 Benzo(a)pyrene results in increased expression of TFE3 mRNA CTD PMID:22228805 bisphenol A multiple interactions ISO RGD:1351703 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TFE3 mRNA CTD PMID:28628672 bisphenol A affects expression ISO RGD:1351703 6480464 bisphenol A affects the expression of TFE3 mRNA CTD PMID:30903817 bisphenol A affects methylation ISO RGD:1557519 6480464 bisphenol A affects the methylation of TFE3 promoter CTD PMID:27334623 bisphenol F multiple interactions ISO RGD:1351703 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TFE3 mRNA CTD PMID:28628672 cadmium dichloride affects localization ISO RGD:1557519 6480464 Cadmium Chloride affects the localization of TFE3 protein CTD PMID:30030080 cadmium dichloride multiple interactions ISO RGD:1557519 6480464 TFE3 protein inhibits the reaction [Cadmium Chloride affects the localization of CTSB protein] more ... CTD PMID:30030080 carbon nanotube increases expression ISO RGD:1557519 6480464 Nanotubes, Carbon analog results in increased expression of TFE3 mRNA CTD PMID:25554681 chloroacetaldehyde increases expression ISO RGD:1351703 6480464 chloroacetaldehyde results in increased expression of TFE3 mRNA CTD PMID:25596134 cisplatin increases expression ISO RGD:1351703 6480464 Cisplatin results in increased expression of TFE3 mRNA CTD PMID:27594783 clodronic acid decreases expression ISO RGD:1351703 6480464 Clodronic Acid results in decreased expression of TFE3 mRNA CTD PMID:25596134 copper(II) sulfate increases expression ISO RGD:1351703 6480464 Copper Sulfate results in increased expression of TFE3 mRNA CTD PMID:19549813 cyclosporin A increases expression EXP 6480464 Cyclosporine results in increased expression of TFE3 mRNA CTD PMID:25596134 cyclosporin A increases expression ISO RGD:1351703 6480464 Cyclosporine results in increased expression of TFE3 mRNA CTD PMID:20106945 more ... cylindrospermopsin increases expression ISO RGD:1351703 6480464 cylindrospermopsin results in increased expression of TFE3 mRNA CTD PMID:24921660 cytarabine increases expression ISO RGD:1351703 6480464 Cytarabine results in increased expression of TFE3 mRNA CTD PMID:19194470 dexamethasone multiple interactions ISO RGD:1351703 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TFE3 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TFE3 mRNA CTD PMID:28628672 dibutyl phthalate increases expression ISO RGD:1557519 6480464 Dibutyl Phthalate results in increased expression of TFE3 mRNA CTD PMID:21266533 dicrotophos increases expression ISO RGD:1351703 6480464 dicrotophos results in increased expression of TFE3 mRNA CTD PMID:28302478 dioxygen increases expression ISO RGD:1351703 6480464 Oxygen deficiency results in increased expression of TFE3 mRNA CTD PMID:25596134 dorsomorphin multiple interactions ISO RGD:1351703 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin decreases expression ISO RGD:1351703 6480464 Doxorubicin results in decreased expression of TFE3 mRNA CTD PMID:29803840 ethanol affects splicing ISO RGD:1557519 6480464 Ethanol affects the splicing of TFE3 mRNA CTD PMID:30319688 ethyl methanesulfonate increases expression ISO RGD:1351703 6480464 Ethyl Methanesulfonate results in increased expression of TFE3 mRNA CTD PMID:23649840 fenofibrate affects expression EXP 6480464 Fenofibrate affects the expression of TFE3 mRNA CTD PMID:25596134 fenofibrate increases expression ISO RGD:1351703 6480464 Fenofibrate results in increased expression of TFE3 mRNA CTD PMID:25596134 fingolimod hydrochloride decreases phosphorylation ISO RGD:1351703 6480464 Fingolimod Hydrochloride results in decreased phosphorylation of TFE3 protein CTD PMID:29945972 flutamide increases expression EXP 6480464 Flutamide results in increased expression of TFE3 mRNA CTD PMID:24136188 fonofos increases methylation ISO RGD:1351703 6480464 Fonofos results in increased methylation of TFE3 promoter CTD PMID:22847954 ibuprofen decreases expression EXP 6480464 Ibuprofen results in decreased expression of TFE3 mRNA CTD PMID:25596134 ibuprofen increases expression ISO RGD:1351703 6480464 Ibuprofen results in increased expression of TFE3 mRNA CTD PMID:25596134 indometacin multiple interactions ISO RGD:1351703 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TFE3 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TFE3 mRNA CTD PMID:28628672 ketamine increases expression EXP 6480464 Ketamine results in increased expression of TFE3 mRNA CTD PMID:20080153 menadione affects expression ISO RGD:1351703 6480464 Vitamin K 3 affects the expression of TFE3 mRNA CTD PMID:20044591 mercury dibromide increases expression ISO RGD:1351703 6480464 mercuric bromide results in increased expression of TFE3 mRNA CTD PMID:26272509 mercury dibromide multiple interactions ISO RGD:1351703 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFE3 mRNA CTD PMID:27188386 metformin increases expression EXP 6480464 Metformin results in increased expression of TFE3 mRNA CTD PMID:25596134 methimazole increases expression EXP 6480464 Methimazole results in increased expression of TFE3 mRNA CTD PMID:22504374 methyl methanesulfonate increases expression ISO RGD:1351703 6480464 Methyl Methanesulfonate results in increased expression of TFE3 mRNA CTD PMID:23649840 methylmercury chloride increases expression ISO RGD:1351703 6480464 methylmercuric chloride results in increased expression of TFE3 mRNA CTD PMID:28001369 N-acetyl-L-cysteine multiple interactions ISO RGD:1351703 6480464 Acetylcysteine inhibits the reaction [sodium arsenite results in decreased phosphorylation of and affects the localization of TFE3 protein] CTD PMID:29945972 N-acetylsphingosine multiple interactions ISO RGD:1351703 6480464 N-acetylsphingosine results in decreased phosphorylation of and affects the localization of TFE3 protein CTD PMID:29945972 nefazodone increases expression EXP 6480464 nefazodone results in increased expression of TFE3 mRNA CTD PMID:24136188 nickel sulfate decreases expression ISO RGD:1351703 6480464 nickel sulfate results in decreased expression of TFE3 mRNA CTD PMID:16780908 okadaic acid multiple interactions ISO RGD:1351703 6480464 Okadaic Acid inhibits the reaction [sodium arsenite results in decreased phosphorylation of and affects the localization of TFE3 protein] CTD PMID:29945972 p-chloromercuribenzoic acid increases expression ISO RGD:1351703 6480464 p-Chloromercuribenzoic Acid results in increased expression of TFE3 mRNA CTD PMID:26272509 p-chloromercuribenzoic acid multiple interactions ISO RGD:1351703 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFE3 mRNA CTD PMID:27188386 paracetamol affects expression ISO RGD:1557519 6480464 Acetaminophen affects the expression of TFE3 mRNA CTD PMID:17562736 parathion increases methylation ISO RGD:1351703 6480464 Parathion results in increased methylation of TFE3 promoter CTD PMID:22847954 pirinixic acid increases expression ISO RGD:1557519 6480464 pirinixic acid results in increased expression of TFE3 mRNA CTD PMID:23811191 SB 431542 multiple interactions ISO RGD:1351703 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 sodium arsenite multiple interactions ISO RGD:1351703 6480464 Acetylcysteine inhibits the reaction [sodium arsenite results in decreased phosphorylation of and affects the localization of TFE3 protein] more ... CTD PMID:29945972 sulforaphane increases expression ISO RGD:1351703 6480464 sulforafan results in increased expression of TFE3 mRNA CTD PMID:26833863 terbufos increases methylation ISO RGD:1351703 6480464 terbufos results in increased methylation of TFE3 promoter CTD PMID:22847954 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of TFE3 mRNA] CTD PMID:31150632 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of TFE3 mRNA CTD PMID:31150632 torin 1 decreases phosphorylation ISO RGD:1557519 6480464 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1, 6)naphthyridin-2(1H)-one results in decreased phosphorylation of TFE3 protein CTD PMID:29945972 tungsten decreases expression ISO RGD:1557519 6480464 Tungsten results in decreased expression of TFE3 mRNA CTD PMID:30912803 urethane increases expression ISO RGD:1351703 6480464 Urethane results in increased expression of TFE3 mRNA CTD PMID:28818685 valproic acid increases methylation ISO RGD:1351703 6480464 Valproic Acid results in increased methylation of TFE3 gene CTD PMID:29154799 valproic acid increases expression ISO RGD:1351703 6480464 Valproic Acid results in increased expression of TFE3 mRNA CTD PMID:28001369 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of TFE3 mRNA CTD PMID:23034163 zebularine increases expression ISO RGD:1351703 6480464 pyrimidin-2-one beta-ribofuranoside results in increased expression of TFE3 mRNA CTD PMID:19194470
Biological Process biological_process ND 1598407 2/2007: no relevant rat data RGD humoral immune response ISO RGD:1557519 1624291 (MGI:MGI:3662947, PMID:16936731) RGD MGI:MGI:3662947 , PMID:16936731 humoral immune response IEA InterPro:IPR024100 1600115 GO_REF:0000002 InterPro GO_REF:0000002 negative regulation of cold-induced thermogenesis ISS UniProtKB:Q64092 13673857 PMID:23885019 YuBioLab negative regulation of cold-induced thermogenesis ISO RGD:1557519 1624291 (MGI:MGI:5525952, PMID:23885019) RGD MGI:MGI:5525952 , PMID:23885019 positive regulation of cell adhesion ISO RGD:1351703 1624291 (PMID:21209915) RGD PMID:21209915 positive regulation of cell adhesion ISS UniProtKB:P19532 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of transcription by RNA polymerase II ISO RGD:1351703 1624291 (PMID:21209915) RGD PMID:21209915 positive regulation of transcription by RNA polymerase II ISS UniProtKB:P19532 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of transcription by RNA polymerase II ISO RGD:1557519 1624291 (MGI:MGI:3662947, PMID:16936731) RGD MGI:MGI:3662947 , PMID:16936731 positive regulation of transcription, DNA-templated ISO RGD:1351703 1624291 (PMID:29146937) RGD PMID:29146937 positive regulation of transcription, DNA-templated ISO RGD:1557519 1624291 (MGI:MGI:3590422 more ... RGD MGI:MGI:3590422 more ... regulation of osteoclast differentiation ISO RGD:1557519 1624291 MGI:MGI:104554 (MGI:MGI:3041714 , PMID:11930005) RGD MGI:MGI:3041714 , PMID:11930005 regulation of osteoclast differentiation IEA InterPro:IPR024100 1600115 GO_REF:0000002 InterPro GO_REF:0000002 Cellular Component cellular_component ND 1598407 2/2007: no relevant rat data RGD cytoplasm ISO RGD:1557519 1624291 (MGI:MGI:5487525, PMID:21209915) RGD MGI:MGI:5487525 , PMID:21209915 cytoplasm ISS UniProtKB:Q64092 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cytosol IEA UniProtKB:A0A024QZ23 , ensembl:ENSP000003141291600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytosol ISO RGD:1351703 1624291 RGD GO_REF:0000052 cytosol IEA UniProtKB:P19532 , ensembl:ENSP000003141291600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleoplasm ISO RGD:1351703 1624291 RGD GO_REF:0000052 nucleoplasm IEA UniProtKB:P19532 , ensembl:ENSP000003141291600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleoplasm IEA UniProtKB:A0A024QZ23 , ensembl:ENSP000003141291600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleus ISO RGD:1351703 1624291 (PMID:21209915) RGD PMID:21209915 nucleus ISS UniProtKB:P19532 1600115 GO_REF:0000024 UniProt GO_REF:0000024 nucleus ISO RGD:1557519 1624291 (MGI:MGI:5487525, PMID:21209915) RGD MGI:MGI:5487525 , PMID:21209915 Molecular Function DNA binding ISO RGD:1557519 1624291 (MGI:MGI:3590422, PMID:15994295) RGD MGI:MGI:3590422 , PMID:15994295 DNA-binding transcription activator activity, RNA polymerase II-specific ISO RGD:1557519 1624291 (MGI:MGI:3662947, PMID:16936731) RGD MGI:MGI:3662947 , PMID:16936731 DNA-binding transcription activator activity, RNA polymerase II-specific IEA UniProtKB:A2AEW1 , ensembl:ENSMUSP000000768641600115 GO_REF:0000107 Ensembl GO_REF:0000107 DNA-binding transcription factor activity ISO RGD:1557519 1624291 (MGI:MGI:3662947, PMID:16936731) RGD MGI:MGI:3662947 , PMID:16936731 molecular_function ND 1598407 2/2007: no relevant rat data RGD protein binding ISO RGD:1351703 1624291 UniProtKB:O15397 (PMID:26168401) RGD PMID:26168401 protein dimerization activity IEA InterPro:IPR011598 more ... 1600115 GO_REF:0000002 InterPro GO_REF:0000002 protein heterodimerization activity ISO RGD:1557519 1624291 UniProtKB:Q9R210 (MGI:MGI:3662947 , PMID:16936731) RGD MGI:MGI:3662947 , PMID:16936731 RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO RGD:1557519 1624291 (MGI:MGI:3662947, PMID:16936731) RGD MGI:MGI:3662947 , PMID:16936731 RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA UniProtKB:A2AEW1 , ensembl:ENSMUSP000000768641600115 GO_REF:0000107 Ensembl GO_REF:0000107 transcription regulatory region DNA binding ISO RGD:1557519 1624291 (MGI:MGI:3662947, PMID:16936731) RGD MGI:MGI:3662947 , PMID:16936731
Gene-Chemical Interaction Annotations
