Gbp1 (guanylate binding protein 1)

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Gene: Gbp1 (guanylate binding protein 1) Rattus norvegicus

Analyze

Symbol:

Gbp1

Name:

guanylate binding protein 1

RGD ID:

1311877

Description:

Predicted to enable several functions, including Hsp90 protein binding activity; cytoskeletal protein binding activity; and guanyl ribonucleotide binding activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; negative regulation of interleukin-2 production; and regulation of signal transduction. Predicted to act upstream of or within adhesion of symbiont to host; cellular response to interferon-beta; and defense response to other organism. Predicted to be located in several cellular components, including Golgi apparatus; actin cytoskeleton; and vesicle membrane. Orthologous to several human genes including GBP1 (guanylate binding protein 1); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; aconitine.

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

guanylate binding protein 1, interferon-inducible; guanylate binding protein 1, interferon-inducible, 67kDa; guanylate-binding protein 1; interferon-induced guanylate-binding protein 1; LOC304266

RGD Orthologs

Human

Mouse

Dog

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GBP1 (guanylate binding protein 1)	HGNC	EggNOG, Ensembl, HomoloGene, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Gbp2b (guanylate binding protein 2b)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GBP1 (guanylate binding protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	GBP1 (guanylate binding protein 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Homo sapiens (human):	GBP3 (guanylate binding protein 3)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	gbp3 (guanylate binding protein 3)	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	gbp2 (guanylate binding protein 2)	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	si:dkeyp-30d6.2	Alliance	DIOPT (Hieranoid\|OMA\|OrthoFinder\|PANTHER)
Danio rerio (zebrafish):	gbp1 (guanylate binding protein 1)	Alliance	DIOPT (Hieranoid\|OMA\|OrthoFinder\|PANTHER)

Related Pseudogenes:

Gbp1-ps1

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	231,398,136 - 231,432,773 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	231,398,163 - 231,432,131 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	2	248,343,334 - 248,423,402 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	248,398,917 - 248,409,570 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	266,908,013 - 266,948,528 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	240,715,506 - 240,739,741 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	240,702,245 - 240,726,481 (-)	NCBI
Celera	2	223,441,822 - 223,476,423 (+)	NCBI		Celera
Cytogenetic Map	2	q44	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Human Influenza (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

(-)-epigallocatechin 3-gallate (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1,4-benzoquinone (ISO)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxynon-2-enal (ISO)

6alpha-methylprednisolone (ISO)

8'-apo-beta,psi-caroten-8'-al (ISO)

aconitine (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

azathioprine (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

Benzo[k]fluoranthene (ISO)

beta-carotene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

butan-1-ol (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

chloroprene (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

cyclophosphamide (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

diclofenac (ISO)

divanadium pentaoxide (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

ethyl methanesulfonate (ISO)

folic acid (ISO)

formaldehyde (ISO)

fulvestrant (ISO)

genistein (ISO)

gentamycin (EXP)

indometacin (ISO)

isobutanol (ISO)

lipopolysaccharide (ISO)

lucanthone (ISO)

LY294002 (ISO)

metformin (EXP)

methotrexate (ISO)

methylmercury chloride (ISO)

N-acetyl-L-cysteine (ISO)

N-nitrosodiethylamine (ISO)

nickel atom (ISO)

nickel dichloride (ISO)

nickel sulfate (ISO)

ochratoxin A (ISO)

ozone (ISO)

paracetamol (EXP)

paraquat (ISO)

phenformin (EXP)

piroxicam (ISO)

potassium chromate (ISO)

prednisolone (ISO)

propanal (ISO)

rotenone (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

selenium atom (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium aurothiomalate (ISO)

sodium dodecyl sulfate (ISO)

succimer (ISO)

tacrolimus hydrate (ISO)

temozolomide (ISO)

testosterone (EXP,ISO)

testosterone enanthate (ISO)

tetrachloromethane (ISO)

triadimefon (ISO)

tributylstannane (ISO)

trichloroethene (EXP)

trovafloxacin (ISO)

urethane (ISO)

valproic acid (ISO)

vincristine (ISO)

vitamin E (ISO)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of innate immune response (ISO)

adhesion of symbiont to host (ISO)

cellular response to interferon-beta (ISO)

cellular response to interleukin-1 (ISO)

cellular response to lipopolysaccharide (ISO)

cellular response to tumor necrosis factor (ISO)

cellular response to type II interferon (ISO)

cytolysis in another organism (ISO)

defense response to bacterium (ISO)

defense response to Gram-positive bacterium (ISO)

defense response to protozoan (ISO)

innate immune response (ISO)

negative regulation of ERK1 and ERK2 cascade (ISO)

negative regulation of interleukin-2 production (ISO)

negative regulation of protein localization to plasma membrane (ISO)

negative regulation of substrate adhesion-dependent cell spreading (ISO)

negative regulation of T cell receptor signaling pathway (ISO)

non-canonical inflammasome complex assembly (ISO)

positive regulation of pyroptosis (ISO)

protein localization to vacuole (ISO)

regulation of calcium-mediated signaling (ISO)

regulation of protein localization to plasma membrane (ISO)

Cellular Component

actin cytoskeleton (ISO)

cytoplasm (ISO)

cytoplasmic vesicle (ISO)

cytosol (ISO)

Golgi apparatus (ISO)

symbiont cell surface (ISO)

vesicle membrane (ISO)

Molecular Function

actin binding (ISO)

cytokine binding (ISO)

enzyme binding (ISO)

G protein activity (ISO)

GDP binding (ISO)

GDP phosphatase activity (ISO)

GMP binding (ISO)

GTP binding (IBA,ISO)

GTPase activity (IBA,ISO)

Hsp90 protein binding (ISO)

identical protein binding (ISO)

protein binding (ISO)

protein homodimerization activity (ISO)

spectrin binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:3927587	PMID:10676968	PMID:16511497	PMID:17266443	PMID:18025219	PMID:19158679	PMID:21151871	PMID:21551061	PMID:22059445	PMID:22607347	PMID:24337748

Genomics

Comparative Map Data

Gbp1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	231,398,136 - 231,432,773 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	231,398,163 - 231,432,131 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	2	248,343,334 - 248,423,402 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	248,398,917 - 248,409,570 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	266,908,013 - 266,948,528 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	240,715,506 - 240,739,741 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	240,702,245 - 240,726,481 (-)	NCBI
Celera	2	223,441,822 - 223,476,423 (+)	NCBI		Celera
Cytogenetic Map	2	q44	NCBI

GBP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	89,052,319 - 89,065,208 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	1	89,051,882 - 89,065,360 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	89,518,002 - 89,530,891 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	89,290,593 - 89,303,479 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	89,230,025 - 89,242,912	NCBI
Celera	1	87,763,799 - 87,776,851 (-)	NCBI		Celera
Cytogenetic Map	1	p22.2	NCBI
HuRef	1	87,635,350 - 87,648,404 (-)	NCBI		HuRef
CHM1_1	1	89,633,030 - 89,646,086 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	88,895,700 - 88,908,571 (-)	NCBI		T2T-CHM13v2.0

Gbp2b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	142,300,577 - 142,324,940 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	142,300,608 - 142,324,940 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	142,594,816 - 142,619,179 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	142,594,847 - 142,619,179 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	142,257,811 - 142,282,140 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	142,437,940 - 142,556,552 (+)	NCBI		MGSCv36	mm8
MGSCv36	3	143,010,037 - 143,128,879 (+)	NCBI		MGSCv36	mm8
Cytogenetic Map	3	H1	NCBI
cM Map	3	66.69	NCBI

GBP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	59,378,069 - 59,393,388 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	59,273,592 - 59,393,229 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	62,090,305 - 62,103,758 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	59,893,027 - 59,906,504 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	59,785,622 - 59,905,093 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	59,458,618 - 59,472,078 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	59,413,802 - 59,427,260 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	59,899,366 - 59,912,850 (+)	NCBI		UU_Cfam_GSD_1.0

Variants

Variants in Gbp1
449 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	18
Count of miRNA genes:	18
Interacting mature miRNAs:	18
Transcripts:	ENSRNOT00000045855
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	78665619	249053267	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	249053267	Rat
61366	Iddm3	Insulin dependent diabetes mellitus QTL 3	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	189599258	234599258	Rat
61398	Bp50	Blood pressure QTL 50	4.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	189599258	234599258	Rat
2317752	Glom23	Glomerulus QTL 23	3.6		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	2	193452645	245889826	Rat
1598813	Memor9	Memory QTL 9	2.7		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	199341726	234244620	Rat
1598835	Anxrr18	Anxiety related response QTL 18	2.98		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	2	200990457	245990457	Rat
2298479	Eau5	Experimental allergic uveoretinitis QTL 5		0.0021	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	2	202446871	237938339	Rat
7207490	Bss111	Bone structure and strength QTL 111	6.4		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	2	211744537	249053267	Rat
7207482	Bss107	Bone structure and strength QTL 107	7		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	2	211744537	249053267	Rat
7207484	Bss108	Bone structure and strength QTL 108	5.3		femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	2	211744537	249053267	Rat
1298075	Scl17	Serum cholesterol level QTL 17	3.4		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	211744537	249053267	Rat
1549836	Bss2	Bone structure and strength QTL 2	7.5		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	2	211744537	249053267	Rat
2317885	Alcrsp28	Alcohol response QTL 28	2.1	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	212828222	249053267	Rat
1300126	Bp175	Blood pressure QTL 175	3.46		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	214226044	247136170	Rat
2313073	Bmd75	Bone mineral density QTL 75	4.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	2	215377404	237938339	Rat
1331767	Hrtrt12	Heart rate QTL 12	3.373		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	218414747	240841241	Rat
2293833	Kiddil8	Kidney dilation QTL 8	2.9		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	219753301	247136170	Rat
2293844	Kiddil7	Kidney dilation QTL 7	3.5		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	219753301	247136170	Rat
9587428	Epfw6	Epididymal fat weight QTL 6	7.47	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	2	223389739	249053267	Rat
7411555	Bw132	Body weight QTL 132		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	2	223389739	249053267	Rat
631563	Hcuc3	Hepatic copper content QTL 3	3.87		liver copper amount (VT:0003065)	liver copper weight to liver dry weight ratio (CMO:0001512)	2	229059610	249053267	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		13						1
Low		6	18	5	17	5	6	8	12	19	8	10	6
Below cutoff	3	10	31	28	2	28	2	2	19	10	13	1	2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_006224278	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006233425	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008761538	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017591353	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039103866	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACYVU010000079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000045855 ⟹ ENSRNOP00000046300

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	231,517,398 - 231,529,600 (+)	Ensembl
Rnor_6.0 Ensembl	2	248,398,917 - 248,409,570 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000094466 ⟹ ENSRNOP00000086405

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	231,398,163 - 231,432,131 (+)	Ensembl

RefSeq Acc Id:

XM_017591353 ⟹ XP_017446842

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	231,398,136 - 231,432,773 (+)	NCBI
Rnor_6.0	2	248,343,334 - 248,423,402 (+)	NCBI

Sequence:

show sequence

GAGAGCAGTCCTTCACATGTTTTCTTCTGTCATTCAGATCTCTGAAGGACTTTAGAGCTAAAGG
AAGAACAGACAGAGACAAGCAGTGGTGGAAGTCCTCCGTCTCAGTAGTGGAAGTCCTCCTTCTT
AGTGGAAAAGAAAAGCAGGCAAGAAACCATAATGGACATGACCCTACAGATCCACATGCCTGGG
CCCGTGTGCCTCATTGAGAATGTGAAAGGACAATTGAGAGCCAATCAGAAGGCCCTGGAGATCC
TGTCAGCCATTACACAGCCTGTGGTGGTGGTGGCAATAGTGGGCCTCTACCGTACAGGCAAATC
CTACCTGATGAACAAGCTGGCTGGAAAGAAAACTGGATTCTCTCTGGGATCCACTGTGCAGGCT
CATACAAAAGGAATCTGGATGTGGTGTGTGCCTCACCCCAACAAGGCAAACCACATGCTTGTTC
TGCTTGACACTGAGGGCCTGGGTGATGTGGAGAAAGGTGACAACCAGAATGACTGCTGGATCTT
TTCCCTGGCTATTCTTCTAAGCAGCACCTTTGTGTACAACAGCATGGGAGCCATCAACCAGCAG
GCCATGGACCAGCTGCACTATGTGACAGAGCTCACAGATCGGATCCGAGCAAGATCCTCACCTG
ACCAGGATGATGGGGTAGAAGACTCAGCTGAGTTTGTCAGCTTCTTCCCCGACTTTGTGTGGAC
TCTGAGGGATATGACCTTGAAAATGGAAGTGGATGGACTCCAGGTCACAGCAGATGAGTACCTG
GAGATTTCTCTGAAGCTCAAGGAAGGTTCCAGCAAGGAAGTTGAAAAATACAACCTACCCCGAC
TCTGTATTCGTAAGTTTTTCCCAAAGAAGAAATGTTTTGTCTTCTACCCACCCACTGAGTGGAA
AAGGCTTTCTCAGCTGGAGACACTGCAAGAAAATGAGATCGATTCTGAGTTTTTGCAGCAAGTA
GCAGAATTCTGTTTATATGTCTTTAAGGAGTGCAAAGCCAAAACCCTTCCAGGAGGCATCATTG
TCAATGGCCCACGACTAGAAACCCTGGTGCTGACCTATCTCAGTGCCATCGGCAGTGGAGATCT
CCCCTGCATGGAGAACGCGGTCCTGACTTTGGCCCAGATAGAGAACTCAGCAGCAGTGGAAAAG
GCCATCACCCACTATGACCAACAGATGAGCCAGAGGGTACAGCTGCCCACAGAGACCCTCCAGG
AGCTGCTGGACCTGCACAGGACCTGTGAGAGAGAGGCCATAGAAATCTTCCTCAGGGTCTCCTT
TAAAGATGAAGATCATTCATTTCAAATGAAATTAGGGTCTCGGCTAGAAGAAAGGTGGAACGAC
TTCTGTAAACGCAATATGGAAGTGTCATCTAACCGTTGCTGGGCTTTGCTTCAAGATATCTTCA
GACCTCTTGAAGAAAGTGTGAAGCAAGGCACTTATTCTAAGCCAGGAGGTTATTACCTCTTTGT
TCAGGAAACACAGAGGCTGAAGGAAAAGTACCAAGGACAACCAAAGAAGGGCTTACAGGCTGAT
GAGGTTCTGCAGAAATATTTACAATCCAAGGAGGCTATTACTACTGCAATTTTACAGACAGATC
AGAGTCTGACAGAAAAGGAAAAGGAGATTGAAGTGGAACGGAAGAAAGCTGAATCTGCACAGGC
TGCTGCAAAGCTGTTGGAGGAAACACAGAAGAAAAATGAGAAGCTGATGGAGCAGAAAGAAAGA
AGTTATCAGGAGCACATGAAACAGTTGACTGAGAAAATGGAGAATGACAGAATCCAATTAAAAG
CAGAGCAAGAGCGGATATTATCTCTAAAACTTCAGGAGCAGAAGCAGCTACTTCAGGAGGGGTT
CCGAGAAGAAAGCAGAAAGCTTCAAGAAGAGATGAAGAATGTGGAGAAGAGATACAAAGAAACA
ATGGATCATATGAAAGCTGAATCTTCAAAGACTAAAGAAGAAATGCAAAGGAAGTATGAGCAGA
TGTTGGAAAAAGACAGGAATCACCAGGAACATACACTACATATGATAGAAAAGATGGAGAGGGA
CAGAGCACAGTTAGTAGCAGAGCAAGAGAAGACAATGACTCTTATCCTTCAGGAGAGAGAACTA
CAGCTCAGGAATGAACTTGCTGAAGAGAGAAGAAAGCACGAGAAAGAGATTCAGGATATAGTGG
CTGAAAACAGACAAATAATCTTGAAATTGGAATCTGAACGAGCTGAGTCTGCAGAGAACACAAT
AAAAATGTTGACGGAATTGAATGAGTTGAATCTGAAGACTTTAGGCCAGAAACAAAAAACTCTT
GAGGATCATTTGATACAATTGACTGAGCAGAGAGACAAGGATACAGCAAGTCTAATGGCAGAAC
AAGGGAAGATCTTCGATAGTAAGCTTCAGGAACAAGAAGAAAATTTCAATAAAAAAATCCGGGC
TCAGAGTCAACAACATCGGGAAGAAATTTGGAAAATCAAGAAAGAGGGTTTTAGTTGTTCCTTG
ATGTGAAAAGTCTAACCAGAGCAGCTTGCACCCCTGCTCTCTCCTTTCAGGAAGGAATTTTTCT
GACATACTTTGGGCCATCTCAAATTCAAAACTAAATACAATTCAAAATAATAAAGATGTCAAAG
CCTAAGAGCATGTGGTCTTGTAGAATTAAGTGTAAGAGTAGGGTGCCCTGGGACATATCGATAG
ATCCATAGGAAGTGATTTCAAACTTTGATATTACAGTACTGAGGATACACATGCCATAATTATT
GATGTGGCCAAGCTTCTAGCTTGCTCCCAGCTTCGATTGAATCTGCAAATAAAAGAGACACAAC
CATTTGTTCCTTTTCAACTTGCCTTTTTAGTCCAATTGCTGGGAGCTACTGTCTCCCACCTGGA
AAACATGGCCTTATCAATACTTTTAGCTCTCATCTCCCTCCTTTAGTCCATCAGTTGAAATTTG
TCCTTGCTAAACACCTCTGACCACCCATCTATAGGAGTGGCTACGGCCCACCACTCCTCCCAAG
ACCTTACATGGTTGCTTGGTTCTCCTCTCCCCAAGGCATGGCAAACTCCCCTCTCTCCTTCCTT
GCAACTTCACTTTCCTCCAGGGACTTGAAAGTTCTGCCTTCACCTTCTGCCTAGCAATTGGCCC
ATGTCTTTCTGTACTAACAGATCAAAAGCCAATTGGAGAACAGGACTTCAGCATCGGAAGTACA
ATAAGCTTTGGTGTGATTCACTGGGGGAAATACAAACAATATGTACAAAAATAAAACTATATTG
AGTGTCTACTAA

hide sequence

RefSeq Acc Id:

XM_039103866 ⟹ XP_038959794

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	231,399,471 - 231,432,773 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_017446842	(Get FASTA)	NCBI Sequence Viewer
	XP_038959794	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_017446842 ⟸ XM_017591353

- UniProtKB:

A0A8I6GE08 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDMTLQIHMPGPVCLIENVKGQLRANQKALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKK
TGFSLGSTVQAHTKGIWMWCVPHPNKANHMLVLLDTEGLGDVEKGDNQNDCWIFSLAILLSSTF
VYNSMGAINQQAMDQLHYVTELTDRIRARSSPDQDDGVEDSAEFVSFFPDFVWTLRDMTLKMEV
DGLQVTADEYLEISLKLKEGSSKEVEKYNLPRLCIRKFFPKKKCFVFYPPTEWKRLSQLETLQE
NEIDSEFLQQVAEFCLYVFKECKAKTLPGGIIVNGPRLETLVLTYLSAIGSGDLPCMENAVLTL
AQIENSAAVEKAITHYDQQMSQRVQLPTETLQELLDLHRTCEREAIEIFLRVSFKDEDHSFQMK
LGSRLEERWNDFCKRNMEVSSNRCWALLQDIFRPLEESVKQGTYSKPGGYYLFVQETQRLKEKY
QGQPKKGLQADEVLQKYLQSKEAITTAILQTDQSLTEKEKEIEVERKKAESAQAAAKLLEETQK
KNEKLMEQKERSYQEHMKQLTEKMENDRIQLKAEQERILSLKLQEQKQLLQEGFREESRKLQEE
MKNVEKRYKETMDHMKAESSKTKEEMQRKYEQMLEKDRNHQEHTLHMIEKMERDRAQLVAEQEK
TMTLILQERELQLRNELAEERRKHEKEIQDIVAENRQIILKLESERAESAENTIKMLTELNELN
LKTLGQKQKTLEDHLIQLTEQRDKDTASLMAEQGKIFDSKLQEQEENFNKKIRAQSQQHREEIW
KIKKEGFSCSLM

hide sequence

RefSeq Acc Id:

ENSRNOP00000046300 ⟸ ENSRNOT00000045855

RefSeq Acc Id:	XP_038959794 ⟸ XM_039103866
- UniProtKB:	A0A8I6GE08 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000086405 ⟸ ENSRNOT00000094466

Protein Domains

GB1/RHD3-type G

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZKU6-F1-model_v2	AlphaFold	D3ZKU6	1-593	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311877	AgrOrtholog
BioCyc Gene	G2FUF-50995	BioCyc
Ensembl Genes	ENSRNOG00000023943	Ensembl, UniProtKB/TrEMBL
	ENSRNOG00000068984	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000046300.5	UniProtKB/TrEMBL
	ENSRNOP00000086405	ENTREZGENE
	ENSRNOP00000086405.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000045855.5	UniProtKB/TrEMBL
	ENSRNOT00000094466	ENTREZGENE
	ENSRNOT00000094466.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.300	UniProtKB/TrEMBL
	Guanylate-binding protein, C-terminal domain	UniProtKB/TrEMBL
InterPro	G_GB1_RHD3_dom	UniProtKB/TrEMBL
	GBP_C	UniProtKB/TrEMBL
	Guanylate-bd/ATL_C	UniProtKB/TrEMBL
	Guanylate-bd_C_sf	UniProtKB/TrEMBL
	Guanylate-bd_N	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
NCBI Gene	304266	ENTREZGENE
PANTHER	GUANYLATE BINDING PROTEIN	UniProtKB/TrEMBL
	GUANYLATE-BINDING PROTEIN 3	UniProtKB/TrEMBL
Pfam	GBP	UniProtKB/TrEMBL
	GBP_C	UniProtKB/TrEMBL
PhenoGen	Gbp1	PhenoGen
PROSITE	G_GB1_RHD3	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48340	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
UniProt	A0A8I6GE08	ENTREZGENE, UniProtKB/TrEMBL
	D3ZKU6_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-01-27	Gbp1	guanylate binding protein 1	Gbp1	guanylate binding protein 1, interferon-inducible	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-09-29	Gbp1	guanylate binding protein 1, interferon-inducible	Gbp1	guanylate binding protein 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-04-27	Gbp1	guanylate binding protein 1	Gbp1	guanylate binding protein 1, interferon-inducible, 67kDa	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Gbp1	guanylate binding protein 1, interferon-inducible, 67kDa	Gbp1_predicted	guanylate binding protein 1, interferon-inducible, 67kDa (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Gbp1_predicted	guanylate binding protein 1, interferon-inducible, 67kDa (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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