Mastl (microtubule associated serine/threonine kinase-like) - Rat Genome Database

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Gene: Mastl (microtubule associated serine/threonine kinase-like) Rattus norvegicus
Analyze
Symbol: Mastl
Name: microtubule associated serine/threonine kinase-like
RGD ID: 1309186
Description: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including meiotic chromosome condensation; negative regulation of phosphoprotein phosphatase activity; and regulation of meiotic cell cycle. Predicted to act upstream of or within female meiosis II and positive regulation of ubiquitin protein ligase activity. Predicted to be located in cleavage furrow; microtubule cytoskeleton; and nucleoplasm. Human ortholog(s) of this gene implicated in thrombocytopenia. Orthologous to human MASTL (microtubule associated serine/threonine kinase like); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC102553656; LOC307169; microtubule-associated serine/threonine-protein kinase-like; serine/threonine-protein kinase greatwall; serine/threonine-protein kinase greatwall-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21785,250,512 - 85,287,479 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1785,251,997 - 85,287,353 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1788,736,222 - 88,771,568 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01792,571,598 - 92,606,946 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01786,588,377 - 86,623,723 (-)NCBIRnor_WKY
Rnor_6.01789,839,562 - 89,875,855 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1789,742,140 - 89,876,825 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01791,504,296 - 91,540,607 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41796,722,615 - 96,757,971 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11796,733,772 - 96,751,272 (-)NCBI
Celera1783,608,795 - 83,644,003 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. FLJ14813 missense mutation: a candidate for autosomal dominant thrombocytopenia on human chromosome 10. Gandhi MJ, etal., Hum Hered. 2003;55(1):66-70.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:14760703   PMID:20538976   PMID:20818157   PMID:23843240   PMID:25246615  


Genomics

Comparative Map Data
Mastl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21785,250,512 - 85,287,479 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1785,251,997 - 85,287,353 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1788,736,222 - 88,771,568 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01792,571,598 - 92,606,946 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01786,588,377 - 86,623,723 (-)NCBIRnor_WKY
Rnor_6.01789,839,562 - 89,875,855 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1789,742,140 - 89,876,825 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01791,504,296 - 91,540,607 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41796,722,615 - 96,757,971 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11796,733,772 - 96,751,272 (-)NCBI
Celera1783,608,795 - 83,644,003 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
MASTL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381027,154,479 - 27,187,953 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1027,154,824 - 27,187,953 (+)EnsemblGRCh38hg38GRCh38
GRCh371027,444,281 - 27,476,882 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361027,484,298 - 27,515,854 (+)NCBINCBI36Build 36hg18NCBI36
Build 341027,484,297 - 27,515,854NCBI
Celera1027,160,210 - 27,192,290 (+)NCBICelera
Cytogenetic Map10p12.1NCBI
HuRef1027,112,454 - 27,144,522 (+)NCBIHuRef
CHM1_11027,443,697 - 27,475,780 (+)NCBICHM1_1
T2T-CHM13v2.01027,185,375 - 27,217,949 (+)NCBIT2T-CHM13v2.0
Mastl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39223,006,549 - 23,046,036 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl223,005,618 - 23,046,036 (-)EnsemblGRCm39 Ensembl
GRCm38223,116,539 - 23,156,024 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl223,115,606 - 23,156,024 (-)EnsemblGRCm38mm10GRCm38
MGSCv37222,972,064 - 23,011,544 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36222,940,074 - 22,977,925 (-)NCBIMGSCv36mm8
Celera222,848,204 - 22,887,677 (-)NCBICelera
Cytogenetic Map2A3NCBI
Mastl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554292,591,203 - 2,617,784 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554292,591,173 - 2,617,084 (+)NCBIChiLan1.0ChiLan1.0
MASTL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11027,626,892 - 27,658,180 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1027,626,892 - 27,658,180 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01027,264,475 - 27,296,085 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MASTL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.126,829,309 - 6,863,876 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl26,830,168 - 6,863,568 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha25,582,408 - 5,616,987 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.025,018,871 - 5,053,474 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.124,395,980 - 4,430,831 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.024,472,486 - 4,507,336 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.024,639,192 - 4,673,999 (+)NCBIUU_Cfam_GSD_1.0
Mastl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934426,109,771 - 26,141,730 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364842,276,744 - 2,306,035 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049364842,276,463 - 2,306,119 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MASTL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1048,856,072 - 48,880,475 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11048,855,895 - 48,877,504 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21054,162,099 - 54,186,773 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MASTL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1926,752,354 - 26,786,802 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl926,753,331 - 26,787,019 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605132,761,322 - 32,796,246 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mastl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247962,216,034 - 2,243,962 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247962,215,951 - 2,244,307 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mastl
219 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:269
Count of miRNA genes:182
Interacting mature miRNAs:203
Transcripts:ENSRNOT00000023698
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358295Aocep1Aortic cell protein QTL 16.10.00000071thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175004027186533673Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175090909986022412Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)176078142686533673Rat
7411577Bw141Body weight QTL 1410.001body mass (VT:0001259)body weight gain (CMO:0000420)176261951686533673Rat

Markers in Region
BE107567  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21785,285,767 - 85,285,939 (-)MAPPERmRatBN7.2
Rnor_6.01789,841,063 - 89,841,234NCBIRnor6.0
Rnor_6.01789,743,564 - 89,743,735NCBIRnor6.0
Rnor_5.01791,505,815 - 91,505,986UniSTSRnor5.0
Rnor_5.01791,408,316 - 91,408,487UniSTSRnor5.0
RGSC_v3.41796,756,386 - 96,756,557UniSTSRGSC3.4
Celera1783,610,209 - 83,610,380UniSTS
RH 3.4 Map17841.1UniSTS
Cytogenetic Map17q12.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 10 10 4 7 4 16 12 28
Low 3 28 42 32 12 32 8 8 50 19 13 11 8
Below cutoff 5 5 5 5 3 8 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000077899   ⟹   ENSRNOP00000074792
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1785,251,997 - 85,287,353 (-)Ensembl
Rnor_6.0 Ensembl1789,742,140 - 89,876,825 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106298   ⟹   ENSRNOP00000085820
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1785,252,045 - 85,287,317 (-)Ensembl
RefSeq Acc Id: NM_001107369   ⟹   NP_001100839
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21785,251,997 - 85,287,353 (-)NCBI
Rnor_6.01789,839,649 - 89,874,391 (+)NCBI
Rnor_5.01791,504,296 - 91,540,607 (+)NCBI
RGSC_v3.41796,722,615 - 96,757,971 (-)RGD
Celera1783,608,795 - 83,644,003 (+)RGD
Sequence:
RefSeq Acc Id: XM_006254340   ⟹   XP_006254402
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21785,250,512 - 85,287,479 (-)NCBI
Rnor_6.01789,839,562 - 89,875,855 (+)NCBI
Rnor_5.01791,504,296 - 91,540,607 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006254341   ⟹   XP_006254403
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21785,250,512 - 85,287,479 (-)NCBI
Rnor_6.01789,839,562 - 89,875,855 (+)NCBI
Rnor_5.01791,504,296 - 91,540,607 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039095809   ⟹   XP_038951737
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21785,250,512 - 85,287,479 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001100839 (Get FASTA)   NCBI Sequence Viewer  
  XP_006254402 (Get FASTA)   NCBI Sequence Viewer  
  XP_006254403 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951737 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL83930 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001100839   ⟸   NM_001107369
- Sequence:
RefSeq Acc Id: XP_006254402   ⟸   XM_006254340
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006254403   ⟸   XM_006254341
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000074792   ⟸   ENSRNOT00000077899
RefSeq Acc Id: XP_038951737   ⟸   XM_039095809
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000085820   ⟸   ENSRNOT00000106298
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A355-F1-model_v2 AlphaFold D4A355 1-866 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309186 AgrOrtholog
BioCyc Gene G2FUF-8478 BioCyc
Ensembl Genes ENSRNOG00000054474 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000074792 ENTREZGENE
  ENSRNOP00000074792.1 UniProtKB/TrEMBL
  ENSRNOP00000085820.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000077899 ENTREZGENE
  ENSRNOT00000077899.2 UniProtKB/TrEMBL
  ENSRNOT00000106298.1 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  MASTL_STKc UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene 307169 ENTREZGENE
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Mastl PhenoGen
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A8I6A106_RAT UniProtKB/TrEMBL
  D4A355_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Mastl  microtubule associated serine/threonine kinase-like  LOC102553656  serine/threonine-protein kinase greatwall-like  Data Merged 737654 PROVISIONAL
2013-12-18 LOC102553656  serine/threonine-protein kinase greatwall-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Mastl  microtubule associated serine/threonine kinase-like   Mastl_predicted  microtubule associated serine/threonine kinase-like (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Mastl_predicted  microtubule associated serine/threonine kinase-like (predicted)      Symbol and Name status set to approved 70820 APPROVED