MASTL (microtubule associated serine/threonine kinase like) - Rat Genome Database

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Gene: MASTL (microtubule associated serine/threonine kinase like) Canis lupus familiaris
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Symbol: MASTL
Name: microtubule associated serine/threonine kinase like
RGD ID: 12110318
Description: ENCODES a protein that exhibits kinase activity (ortholog); protein phosphatase 2A binding (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN DNA damage response (ortholog); female meiosis II (ortholog); G2/M transition of mitotic cell cycle (ortholog); ASSOCIATED WITH Scimitar Anomaly, Multiple Cardiac Malformations, and Craniofacial and Central Nervous System Abnormalities (ortholog); thrombocytopenia (ortholog); Thrombocytopenia 2 (ortholog); FOUND IN centrosome (ortholog); cleavage furrow (ortholog); intracellular membrane-bounded organelle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: GW; GWL; MAST-L; Microtubule-associated serine/threonine-protein kinase-like; Serine/threonine-protein kinase greatwall
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.126,829,309 - 6,863,876 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl26,830,168 - 6,863,568 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha25,582,408 - 5,616,987 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.025,018,871 - 5,053,474 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl25,019,818 - 5,053,476 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.124,395,980 - 4,430,831 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.024,472,486 - 4,507,336 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.024,639,192 - 4,673,999 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MASTL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.126,829,309 - 6,863,876 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl26,830,168 - 6,863,568 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha25,582,408 - 5,616,987 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.025,018,871 - 5,053,474 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl25,019,818 - 5,053,476 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.124,395,980 - 4,430,831 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.024,472,486 - 4,507,336 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.024,639,192 - 4,673,999 (+)NCBIUU_Cfam_GSD_1.0
MASTL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381027,154,479 - 27,187,953 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1027,154,824 - 27,187,953 (+)EnsemblGRCh38hg38GRCh38
GRCh371027,444,281 - 27,476,882 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361027,484,298 - 27,515,854 (+)NCBINCBI36Build 36hg18NCBI36
Build 341027,484,297 - 27,515,854NCBI
Celera1027,160,210 - 27,192,290 (+)NCBICelera
Cytogenetic Map10p12.1NCBI
HuRef1027,112,454 - 27,144,522 (+)NCBIHuRef
CHM1_11027,443,697 - 27,475,780 (+)NCBICHM1_1
T2T-CHM13v2.01027,184,483 - 27,217,949 (+)NCBIT2T-CHM13v2.0
Mastl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39223,006,549 - 23,046,036 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl223,005,618 - 23,046,036 (-)EnsemblGRCm39 Ensembl
GRCm38223,116,539 - 23,156,024 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl223,115,606 - 23,156,024 (-)EnsemblGRCm38mm10GRCm38
MGSCv37222,972,064 - 23,011,544 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36222,940,074 - 22,977,925 (-)NCBIMGSCv36mm8
Celera222,848,204 - 22,887,677 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map215.23NCBI
Mastl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81790,158,592 - 90,195,550 (-)NCBIGRCr8
mRatBN7.21785,250,512 - 85,287,479 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1785,251,997 - 85,287,353 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1788,736,222 - 88,771,568 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01792,571,598 - 92,606,946 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01786,588,377 - 86,623,723 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01789,839,562 - 89,875,855 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1789,742,140 - 89,876,825 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01791,504,296 - 91,540,607 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41796,722,615 - 96,757,971 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11796,733,772 - 96,751,272 (-)NCBI
Celera1783,608,795 - 83,644,003 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
Mastl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554292,591,203 - 2,617,784 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554292,591,173 - 2,617,084 (+)NCBIChiLan1.0ChiLan1.0
MASTL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2839,783,630 - 39,816,414 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11039,788,957 - 39,821,737 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01027,264,475 - 27,296,085 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11027,626,892 - 27,658,180 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1027,626,892 - 27,658,180 (+)Ensemblpanpan1.1panPan2
Mastl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934426,109,771 - 26,141,730 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364842,276,744 - 2,306,035 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364842,276,463 - 2,306,119 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MASTL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1048,856,072 - 48,880,475 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11048,855,895 - 48,877,504 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21054,162,099 - 54,186,773 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MASTL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1926,752,354 - 26,786,802 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl926,753,331 - 26,787,019 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605132,761,322 - 32,796,246 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mastl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247962,216,034 - 2,243,962 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247962,215,951 - 2,244,307 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MASTL
299 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 32 21 12 14 10

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005616976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022406238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038469023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038469024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038469025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038529730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038529731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038529732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038593969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038593970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038593971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038658051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038658052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038658053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_843773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCAFT00000007043   ⟹   ENSCAFP00000006520
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl26,830,168 - 6,863,568 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845006235   ⟹   ENSCAFP00845004956
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl25,019,818 - 5,053,476 (+)Ensembl
RefSeq Acc Id: XM_005616976   ⟹   XP_005617033
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.126,833,350 - 6,863,876 (+)NCBI
Dog10K_Boxer_Tasha25,586,548 - 5,616,987 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022406238   ⟹   XP_022261946
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.126,834,626 - 6,863,876 (+)NCBI
Dog10K_Boxer_Tasha25,587,807 - 5,616,987 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038469023   ⟹   XP_038324951
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.124,395,980 - 4,430,831 (+)NCBI
RefSeq Acc Id: XM_038469024   ⟹   XP_038324952
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.124,400,120 - 4,430,831 (+)NCBI
RefSeq Acc Id: XM_038469025   ⟹   XP_038324953
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.124,401,378 - 4,430,831 (+)NCBI
RefSeq Acc Id: XM_038529730   ⟹   XP_038385658
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.024,639,192 - 4,673,999 (+)NCBI
RefSeq Acc Id: XM_038529731   ⟹   XP_038385659
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.024,643,334 - 4,673,999 (+)NCBI
RefSeq Acc Id: XM_038529732   ⟹   XP_038385660
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.024,644,592 - 4,673,999 (+)NCBI
RefSeq Acc Id: XM_038593969   ⟹   XP_038449897
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.024,472,486 - 4,507,336 (+)NCBI
RefSeq Acc Id: XM_038593970   ⟹   XP_038449898
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.024,476,627 - 4,507,336 (+)NCBI
RefSeq Acc Id: XM_038593971   ⟹   XP_038449899
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.024,477,893 - 4,507,336 (+)NCBI
RefSeq Acc Id: XM_038658051   ⟹   XP_038513979
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.025,018,871 - 5,053,474 (+)NCBI
RefSeq Acc Id: XM_038658052   ⟹   XP_038513980
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.025,023,013 - 5,053,474 (+)NCBI
RefSeq Acc Id: XM_038658053   ⟹   XP_038513981
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.025,024,279 - 5,053,474 (+)NCBI
RefSeq Acc Id: XM_843773   ⟹   XP_848866
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.126,829,309 - 6,863,876 (+)NCBI
Dog10K_Boxer_Tasha25,582,408 - 5,616,987 (+)NCBI
Sequence:
RefSeq Acc Id: XP_848866   ⟸   XM_843773
- Peptide Label: isoform X1
- UniProtKB: E2RJI4 (UniProtKB/Swiss-Prot),   A0A8C0LMA8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005617033   ⟸   XM_005616976
- Peptide Label: isoform X2
- UniProtKB: E2RJI4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_022261946   ⟸   XM_022406238
- Peptide Label: isoform X3
- UniProtKB: E2RJI4 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSCAFP00000006520   ⟸   ENSCAFT00000007043
RefSeq Acc Id: XP_038324951   ⟸   XM_038469023
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038324952   ⟸   XM_038469024
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038324953   ⟸   XM_038469025
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038449897   ⟸   XM_038593969
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038449898   ⟸   XM_038593970
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038449899   ⟸   XM_038593971
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038513979   ⟸   XM_038658051
- Peptide Label: isoform X1
- UniProtKB: E2RJI4 (UniProtKB/Swiss-Prot),   A0A8C0LMA8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038513980   ⟸   XM_038658052
- Peptide Label: isoform X2
- UniProtKB: E2RJI4 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038513981   ⟸   XM_038658053
- Peptide Label: isoform X3
- UniProtKB: E2RJI4 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038385658   ⟸   XM_038529730
- Peptide Label: isoform X1
- UniProtKB: E2RJI4 (UniProtKB/Swiss-Prot),   A0A8C0LMA8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038385659   ⟸   XM_038529731
- Peptide Label: isoform X2
- UniProtKB: E2RJI4 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038385660   ⟸   XM_038529732
- Peptide Label: isoform X3
- UniProtKB: E2RJI4 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSCAFP00845004956   ⟸   ENSCAFT00845006235

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000004382 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030013571 UniProtKB/TrEMBL
  ENSCAFG00040002702 UniProtKB/TrEMBL
  ENSCAFG00845003497 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000007043.5 UniProtKB/TrEMBL
  ENSCAFT00030025222.1 UniProtKB/TrEMBL
  ENSCAFT00040005141.1 UniProtKB/TrEMBL
  ENSCAFT00845006235 ENTREZGENE
  ENSCAFT00845006235.1 UniProtKB/TrEMBL
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MASTL_STKc UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser_Thr_kinase_AGC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene MASTL ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE GREATWALL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0LMA8 ENTREZGENE
  A0A8C0RJK9_CANLF UniProtKB/TrEMBL
  A0A8I3MPU6_CANLF UniProtKB/TrEMBL
  E2RJI4 ENTREZGENE, UniProtKB/Swiss-Prot
VGNC ID VGNC:43036 ENTREZGENE