Pik3cb (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta) - Rat Genome Database

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Gene: Pik3cb (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta) Rattus norvegicus
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Symbol: Pik3cb
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
RGD ID: 620917
Description: Enables 1-phosphatidylinositol-3-kinase activity. Involved in phosphatidylinositol phosphate biosynthetic process. Located in brush border membrane. Part of phosphatidylinositol 3-kinase complex. Used to study thrombosis. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in glioblastoma; prostate adenocarcinoma; prostate cancer; and type 2 diabetes mellitus. Orthologous to human PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; FasL mediated signaling pathway; phosphatidylinositol 3-kinase class I signaling pathway; INTERACTS WITH 17beta-estradiol; 2,6-dinitrotoluene; allethrin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: catalytic phosphatidylinositol 3-kinase beta; LOC100910021; p110beta; phosphatidylinositol 3-kinase catalytic subunit beta isoform; phosphatidylinositol 3-kinase, catalytic subunit, beta isoform; phosphatidylinositol 3-kinase, catalytic, beta polypeptide; phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; phosphoinositide-3-kinase, catalytic, beta polypeptide; PI3-kinase p110 subunit beta; PI3-kinase subunit beta; PI3K; PI3K-beta; PI3Kbeta; ptdIns-3-kinase p110; ptdIns-3-kinase subunit beta; ptdIns-3-kinase subunit p110-beta; serine/threonine protein kinase PIK3CB
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88108,474,017 - 108,579,140 (-)NCBIGRCr8
mRatBN7.2899,594,600 - 99,699,772 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl899,594,644 - 99,699,663 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8105,261,003 - 105,332,672 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08103,460,307 - 103,531,975 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08101,302,802 - 101,374,469 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08107,275,849 - 107,381,088 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8107,275,725 - 107,380,933 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08106,700,158 - 106,788,063 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48103,886,682 - 103,957,112 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18103,906,136 - 103,976,567 (-)NCBI
Celera899,000,434 - 99,072,100 (-)NCBICelera
Cytogenetic Map8q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methylcholanthrene  (ISO)
4-hydroxynon-2-enal  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
alpha-phellandrene  (ISO)
aristolochic acid A  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (ISO)
capecitabine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
decabromodiphenyl ether  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dioscin  (ISO)
dioxygen  (ISO)
Doramectin  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
fenthion  (ISO)
fenvalerate  (EXP)
fulvestrant  (ISO)
gentamycin  (EXP)
idelalisib  (ISO)
lead(0)  (ISO)
LY294002  (ISO)
metformin  (ISO)
methidathion  (ISO)
methylmercury(1+)  (ISO)
microcystin-LR  (ISO)
morin  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (EXP)
ochratoxin A  (ISO)
ozone  (ISO)
paracetamol  (EXP)
permethrin  (EXP)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
potassium chromate  (ISO)
pyrethrins  (EXP)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
Sinomenine  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
streptozocin  (EXP,ISO)
T-2 toxin  (ISO)
tamibarotene  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
valproic acid  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acute myeloid leukemia pathway   (IEA)
aldosterone signaling pathway  (IEA)
apoptotic cell death pathway  (IEA)
B cell receptor signaling pathway  (IEA)
ceramide signaling pathway  (IEA)
Chagas disease pathway  (IEA)
chemokine mediated signaling pathway  (IEA)
chronic myeloid leukemia pathway   (IEA)
colorectal cancer pathway   (IEA)
endometrial cancer pathway  (IEA)
Entamoebiasis pathway   (IEA)
epidermal growth factor/neuregulin signaling pathway   (IEA,ISO)
FasL mediated signaling pathway  (ISO)
Fc epsilon receptor mediated signaling pathway  (IEA)
Fc gamma receptor mediated signaling pathway  (IEA)
glioma pathway  (IEA)
hepatitis C pathway  (IEA)
influenza A pathway  (IEA)
inositol phosphate metabolic pathway   (IEA)
insulin signaling pathway   (IEA)
Jak-Stat signaling pathway  (IEA)
measles pathway  (IEA)
melanoma pathway   (IEA)
mTOR signaling pathway  (IEA)
neurotrophic factor signaling pathway   (IEA)
non-small cell lung carcinoma pathway   (IEA)
pancreatic cancer pathway  (IEA)
phosphatidylinositol 3-kinase class I signaling pathway  (ISO)
phosphatidylinositol 3-kinase signaling pathway   (IEA)
phosphatidylinositol 3-kinase-Akt signaling pathway  (ISO)
platelet-derived growth factor signaling pathway   (ISO)
prostate cancer pathway   (IEA)
renal cell carcinoma pathway  (IEA)
small cell lung carcinoma pathway  (IEA)
T cell receptor signaling pathway   (IEA)
Toll-like receptor signaling pathway  (IEA)
toxoplasmosis pathway   (IEA)
Trail mediated signaling pathway   (ISO)
type 2 diabetes mellitus pathway   (IEA)
vascular endothelial growth factor signaling pathway  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Bile acid depletion and repletion regulate cholangiocyte growth and secretion by a phosphatidylinositol 3-kinase-dependent pathway in rats. Alpini G, etal., Gastroenterology 2002 Oct;123(4):1226-37.
2. Targeted RNA interference of phosphatidylinositol 3-kinase p110-beta induces apoptosis and proliferation arrest in endometrial carcinoma cells. An HJ, etal., J Pathol. 2007 Jun;212(2):161-9.
3. PTEN restoration and PIK3CB knockdown synergistically suppress glioblastoma growth in vitro and in xenografts. Chen H, etal., J Neurooncol. 2011 Aug;104(1):155-67. doi: 10.1007/s11060-010-0492-2. Epub 2010 Dec 29.
4. PI3K-FRAP/mTOR pathway is critical for hepatocyte proliferation whereas MEK/ERK supports both proliferation and survival. Coutant A, etal., Hepatology 2002 Nov;36(5):1079-88.
5. Hepatocyte growth factor activates phosphoinositide 3-kinase C2 beta in renal brush-border plasma membranes. Crljen V, etal., Biochem J 2002 Aug 1;365(Pt 3):791-9.
6. Isoform-specific phosphoinositide 3-kinase inhibitors exert distinct effects in solid tumors. Edgar KA, etal., Cancer Res. 2010 Feb 1;70(3):1164-72. doi: 10.1158/0008-5472.CAN-09-2525. Epub 2010 Jan 26.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Phosphoinositide 3-kinases as a common platform for multi-hormone signaling. Hirsch E, etal., J Endocrinol. 2007 Aug;194(2):243-56.
10. PI 3-kinase p110beta: a new target for antithrombotic therapy. Jackson SP, etal., Nat Med. 2005 May;11(5):507-14. Epub 2005 Apr 17.
11. Platelet-derived growth factor-BB-mediated activation of Akt suppresses smooth muscle-specific gene expression through inhibition of mitogen-activated protein kinase and redistribution of serum response factor. Kaplan-Albuquerque N, etal., J Biol Chem. 2003 Oct 10;278(41):39830-8. Epub 2003 Jul 25.
12. Endometrial cancer cells exhibit high expression of p110ß and its selective inhibition induces variable responses on PI3K signaling, cell survival and proliferation. Karlsson T, etal., Oncotarget. 2017 Jan 17;8(3):3881-3894. doi: 10.18632/oncotarget.13989.
13. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
14. Troglitazone but not metformin restores insulin-stimulated phosphoinositide 3-kinase activity and increases p110beta protein levels in skeletal muscle of type 2 diabetic subjects. Kim YB, etal., Diabetes. 2002 Feb;51(2):443-8.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
19. In vivo regulation of phosphoinositide 3-kinase in retina through light-induced tyrosine phosphorylation of the insulin receptor beta-subunit. Rajala RV, etal., J Biol Chem 2002 Nov 8;277(45):43319-26.
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. MicroRNA126 inhibits proliferation and metastasis by targeting pik3r2 in prostate cancer. Song L, etal., Mol Med Rep. 2016 Feb;13(2):1204-10. doi: 10.3892/mmr.2015.4661. Epub 2015 Dec 9.
24. Survival kinase genes present prognostic significance in glioblastoma. Varghese RT, etal., Oncotarget. 2016 Mar 4. doi: 10.18632/oncotarget.7917.
25. PTEN-deficient cancers depend on PIK3CB. Wee S, etal., Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13057-62. doi: 10.1073/pnas.0802655105. Epub 2008 Aug 28.
26. PIK3CA and PIK3CB expression and relationship with multidrug resistance in colorectal carcinoma. Wen F, etal., Int J Clin Exp Pathol. 2014 Oct 15;7(11):8295-303. eCollection 2014.
27. MicroRNA-21 promotes cell proliferation, migration, and resistance to apoptosis through PTEN/PI3K/AKT signaling pathway in esophageal cancer. Wu YR, etal., Tumour Biol. 2016 Sep;37(9):12061-12070. doi: 10.1007/s13277-016-5074-2. Epub 2016 May 17.
28. ErbB4 protects against neuronal apoptosis via activation of YAP/PIK3CB signaling pathway in a rat model of subarachnoid hemorrhage. Yan F, etal., Exp Neurol. 2017 Nov;297:92-100. doi: 10.1016/j.expneurol.2017.07.014. Epub 2017 Jul 27.
29. Inhibitory effects of Chanling Gao on the proliferation and liver metastasis of transplanted colorectal cancer in nude mice. Yang B, etal., PLoS One. 2019 Feb 21;14(2):e0201504. doi: 10.1371/journal.pone.0201504. eCollection 2019.
30. Phosphatidylinositol 3-kinase CB association with preoperative radiotherapy response in rectal adenocarcinoma. Yu WD, etal., World J Gastroenterol. 2014 Nov 21;20(43):16258-67. doi: 10.3748/wjg.v20.i43.16258.
31. Garlic Oil Suppressed Nitrosodiethylamine-Induced Hepatocarcinoma in Rats by Inhibiting PI3K-AKT-NF-κB Pathway. Zhang CL, etal., Int J Biol Sci. 2015 Apr 25;11(6):643-51. doi: 10.7150/ijbs.10785. eCollection 2015.
32. Phosphoinositide 3-OH kinase p85alpha and p110beta are essential for androgen receptor transactivation and tumor progression in prostate cancers. Zhu Q, etal., Oncogene. 2008 Jul 31;27(33):4569-79. doi: 10.1038/onc.2008.91. Epub 2008 Mar 31.
Additional References at PubMed
PMID:8889548   PMID:11919689   PMID:14379171   PMID:16625210   PMID:19196950   PMID:19578070   PMID:24631588   PMID:25139353   PMID:25249570   PMID:25327288   PMID:25339672   PMID:35717938  
PMID:36739310   PMID:37338759   PMID:37815888  


Genomics

Comparative Map Data
Pik3cb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88108,474,017 - 108,579,140 (-)NCBIGRCr8
mRatBN7.2899,594,600 - 99,699,772 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl899,594,644 - 99,699,663 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8105,261,003 - 105,332,672 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08103,460,307 - 103,531,975 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08101,302,802 - 101,374,469 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08107,275,849 - 107,381,088 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8107,275,725 - 107,380,933 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08106,700,158 - 106,788,063 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48103,886,682 - 103,957,112 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18103,906,136 - 103,976,567 (-)NCBI
Celera899,000,434 - 99,072,100 (-)NCBICelera
Cytogenetic Map8q31NCBI
PIK3CB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383138,652,698 - 138,834,928 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3138,652,698 - 138,834,928 (-)EnsemblGRCh38hg38GRCh38
GRCh373138,371,540 - 138,553,770 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363139,856,921 - 139,960,875 (-)NCBINCBI36Build 36hg18NCBI36
Build 343139,856,928 - 139,960,883NCBI
Celera3136,799,538 - 136,904,134 (-)NCBICelera
Cytogenetic Map3q22.3NCBI
HuRef3135,746,166 - 135,853,444 (-)NCBIHuRef
CHM1_13138,335,402 - 138,442,207 (-)NCBICHM1_1
T2T-CHM13v2.03141,393,413 - 141,575,643 (-)NCBIT2T-CHM13v2.0
Pik3cb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39998,920,455 - 99,022,264 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl998,918,707 - 99,022,674 (-)EnsemblGRCm39 Ensembl
GRCm38999,038,402 - 99,140,235 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl999,036,654 - 99,140,621 (-)EnsemblGRCm38mm10GRCm38
MGSCv37998,938,821 - 99,040,630 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36998,847,754 - 98,949,439 (-)NCBIMGSCv36mm8
Celera998,576,088 - 98,662,033 (-)NCBICelera
Cytogenetic Map9E3.3NCBI
cM Map951.41NCBI
Pik3cb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955501259,645 - 379,909 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955501251,829 - 381,255 (+)NCBIChiLan1.0ChiLan1.0
PIK3CB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22136,561,870 - 136,744,097 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13136,566,598 - 136,748,779 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03135,685,120 - 135,867,096 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13143,288,563 - 143,431,314 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3143,288,563 - 143,431,314 (-)Ensemblpanpan1.1panPan2
PIK3CB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12334,832,661 - 34,955,410 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2334,836,540 - 34,993,939 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2334,826,488 - 35,032,061 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02335,375,472 - 35,581,398 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2335,378,018 - 35,581,338 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12335,056,048 - 35,262,274 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02335,121,991 - 35,327,601 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02335,371,974 - 35,577,846 (-)NCBIUU_Cfam_GSD_1.0
Pik3cb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560274,167,334 - 74,302,042 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936540907,112 - 1,041,848 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936540907,118 - 1,041,814 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIK3CB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1379,425,835 - 79,610,840 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11379,427,033 - 79,610,840 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21387,042,709 - 87,067,016 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIK3CB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11551,705,585 - 51,885,848 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1551,775,733 - 51,889,238 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604124,691,992 - 24,889,924 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pik3cb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473015,226,379 - 15,355,857 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473015,226,786 - 15,399,097 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pik3cb
514 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:43
Count of miRNA genes:39
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000022179
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 9 8 11 8 50 23 6 11
Low 1 43 48 33 8 33 8 11 24 12 35 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005487938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010054039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC111654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ012482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW523465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ202622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV117575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EV762942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EV765206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000022179   ⟹   ENSRNOP00000022179
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl899,594,644 - 99,699,549 (-)Ensembl
Rnor_6.0 Ensembl8107,275,725 - 107,380,933 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000039271   ⟹   ENSRNOP00000035786
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl8106,863,494 - 106,870,994 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112462   ⟹   ENSRNOP00000089360
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl899,663,541 - 99,699,663 (-)Ensembl
RefSeq Acc Id: NM_053481   ⟹   NP_445933
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88108,474,017 - 108,545,708 (-)NCBI
mRatBN7.2899,594,642 - 99,666,336 (-)NCBI
Rnor_6.08107,275,881 - 107,347,573 (-)NCBI
Rnor_5.08106,700,158 - 106,788,063 (-)NCBI
RGSC_v3.48103,886,682 - 103,957,112 (-)RGD
Celera899,000,434 - 99,072,100 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595943   ⟹   XP_017451432
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88108,474,025 - 108,579,140 (-)NCBI
mRatBN7.2899,594,600 - 99,699,772 (-)NCBI
Rnor_6.08107,275,849 - 107,381,088 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595946   ⟹   XP_017451435
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88108,474,025 - 108,579,138 (-)NCBI
mRatBN7.2899,594,600 - 99,699,770 (-)NCBI
Rnor_6.08107,275,849 - 107,381,088 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595947   ⟹   XP_017451436
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88108,474,025 - 108,578,750 (-)NCBI
mRatBN7.2899,594,600 - 99,699,387 (-)NCBI
Rnor_6.08107,275,849 - 107,380,798 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005487938
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88108,474,025 - 108,579,140 (-)NCBI
mRatBN7.2899,594,600 - 99,699,772 (-)NCBI
RefSeq Acc Id: XR_010054039
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88108,474,025 - 108,578,750 (-)NCBI
RefSeq Acc Id: NP_445933   ⟸   NM_053481
- UniProtKB: Q9Z1L0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017451432   ⟸   XM_017595943
- Peptide Label: isoform X1
- UniProtKB: G3V839 (UniProtKB/TrEMBL),   A6I2C5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451435   ⟸   XM_017595946
- Peptide Label: isoform X1
- UniProtKB: G3V839 (UniProtKB/TrEMBL),   A6I2C5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451436   ⟸   XM_017595947
- Peptide Label: isoform X1
- UniProtKB: G3V839 (UniProtKB/TrEMBL),   A6I2C5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000022179   ⟸   ENSRNOT00000022179
RefSeq Acc Id: ENSRNOP00000035786   ⟸   ENSRNOT00000039271
RefSeq Acc Id: ENSRNOP00000089360   ⟸   ENSRNOT00000112462
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M0T1-F1-model_v2 AlphaFold F1M0T1 1-237 view protein structure
AF-Q9Z1L0-F1-model_v2 AlphaFold Q9Z1L0 1-1070 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696208
Promoter ID:EPDNEW_R6732
Type:multiple initiation site
Name:Pik3cb_1
Description:phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunitbeta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08107,380,849 - 107,380,909EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620917 AgrOrtholog
BioCyc Gene G2FUF-29405 BioCyc
BioCyc Pathway PWY-6352 [3-phosphoinositide biosynthesis] BioCyc
BioCyc Pathway Image PWY-6352 BioCyc
Ensembl Genes ENSRNOG00000016384 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000023622 Ensembl
Ensembl Transcript ENSRNOT00000022179.5 UniProtKB/TrEMBL
  ENSRNOT00000112462.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1070.11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.25.40.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.10.20.770 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3/4_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3/4_kinase_cat_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3/4_kinase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_accessory_dom UniProtKB/TrEMBL
  PI3K_accessory_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_adapt-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_Ras-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3Kbeta_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI_Kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PInositide-3_kin_accessory_dom UniProtKB/Swiss-Prot
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:85243 UniProtKB/Swiss-Prot
NCBI Gene 85243 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10048 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PI3_PI4_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_p85B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_rbd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3Ka UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pik3cb PhenoGen
PROSITE PI3_4_KINASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3_4_KINASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3_4_KINASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_ABD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_RBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIK_HELICAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016384 RatGTEx
  ENSRNOG00000023622 RatGTEx
SMART PI3K_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_p85B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_rbd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3Ka UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3Kc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6GH69_RAT UniProtKB/TrEMBL
  A6I2C5 ENTREZGENE, UniProtKB/TrEMBL
  G3V839 ENTREZGENE, UniProtKB/TrEMBL
  PK3CB_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Pik3cb  phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta  LOC100910021  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like  Data merged from RGD:6500836 737654 PROVISIONAL
2012-10-10 Pik3cb  phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta  Pik3cb  phosphoinositide-3-kinase, catalytic, beta polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100910021  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-09 Pik3cb  phosphoinositide-3-kinase, catalytic, beta polypeptide  Pik3cb  phosphatidylinositol 3-kinase, catalytic, beta polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Pik3cb  phosphatidylinositol 3-kinase, catalytic, beta polypeptide    phosphatidylinositol 3-kinase, catalytic subunit, beta isoform  Name updated 1299863 APPROVED
2002-08-07 Pik3cb  phosphatidylinositol 3-kinase, catalytic subunit, beta isoform      Symbol and Name status set to provisional 70820 PROVISIONAL